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Aliases for RESP18 Gene

Aliases for RESP18 Gene

  • Regulated Endocrine-Specific Protein 18 2 3
  • Regulated Endocrine-Specific Protein 18 Homolog (Rat) 2

External Ids for RESP18 Gene

Previous GeneCards Identifiers for RESP18 Gene

  • GC02M220018
  • GC02M219900
  • GC02M220192
  • GC02M212045

Summaries for RESP18 Gene

GeneCards Summary for RESP18 Gene

RESP18 (Regulated Endocrine-Specific Protein 18) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RESP18 Gene

  • May play an important regulatory role in corticotrophs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RESP18 Gene

Genomics for RESP18 Gene

Regulatory Elements for RESP18 Gene

Genomic Location for RESP18 Gene

Start:
219,327,409 bp from pter
End:
219,333,177 bp from pter
Size:
5,769 bases
Orientation:
Minus strand

Genomic View for RESP18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RESP18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RESP18 Gene

Proteins for RESP18 Gene

  • Protein details for RESP18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W5W9-RES18_HUMAN
    Recommended name:
    Regulated endocrine-specific protein 18
    Protein Accession:
    Q5W5W9
    Secondary Accessions:
    • A8MQ49
    • Q38I23
    • Q5W5X0

    Protein attributes for RESP18 Gene

    Size:
    173 amino acids
    Molecular mass:
    19021 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RESP18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RESP18 Gene

Proteomics data for RESP18 Gene at MOPED

Post-translational modifications for RESP18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RESP18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RESP18 Gene

Domains for RESP18 Gene

Protein Domains for RESP18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RESP18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5W5W9

UniProtKB/Swiss-Prot:

RES18_HUMAN :
  • Q5W5W9
Family:
  • Belongs to the RESP18 family.
genes like me logo Genes that share domains with RESP18: view

No data available for Gene Families for RESP18 Gene

Function for RESP18 Gene

Molecular function for RESP18 Gene

UniProtKB/Swiss-Prot Function: May play an important regulatory role in corticotrophs.

Phenotypes for RESP18 Gene

MGI mutant phenotypes for RESP18:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with RESP18: view

Animal Models for RESP18 Gene

MGI Knock Outs for RESP18:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for RESP18 Gene

Localization for RESP18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RESP18 Gene

Secreted. Endoplasmic reticulum. Golgi apparatus. Note=Found in the lumen of dense core vesicles (DCV). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RESP18 Gene COMPARTMENTS Subcellular localization image for RESP18 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
extracellular 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for RESP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum --
GO:0005794 Golgi apparatus IEA --
GO:0030141 secretory granule IEA --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with RESP18: view

Pathways for RESP18 Gene

SuperPathways for RESP18 Gene

No Data Available

Interacting Proteins for RESP18 Gene

Gene Ontology (GO) - Biological Process for RESP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
genes like me logo Genes that share ontologies with RESP18: view

No data available for Pathways by source for RESP18 Gene

Transcripts for RESP18 Gene

mRNA/cDNA for RESP18 Gene

(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(5) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RESP18 Gene

Regulated endocrine-specific protein 18:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RESP18

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RESP18

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RESP18 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - -
SP2: - -
SP3: -

Relevant External Links for RESP18 Gene

GeneLoc Exon Structure for
RESP18
ECgene alternative splicing isoforms for
RESP18

Expression for RESP18 Gene

mRNA expression in normal human tissues for RESP18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RESP18 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (15.4), Brain - Putamen (basal ganglia) (13.1), and Brain - Caudate (basal ganglia) (12.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RESP18 Gene

SOURCE GeneReport for Unigene cluster for RESP18 Gene Hs.290551

mRNA Expression by UniProt/SwissProt for RESP18 Gene

Q5W5W9-RES18_HUMAN
Tissue specificity: Pancreas. Found in alpha, beta and delta cells in the pancreatic islets.
genes like me logo Genes that share expressions with RESP18: view

In Situ Assay Products

Orthologs for RESP18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RESP18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RESP18 35
  • 98.25 (n)
  • 95.18 (a)
RESP18 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RESP18 35
  • 81.12 (n)
  • 68.53 (a)
RESP18 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Resp18 35
  • 72.78 (n)
  • 57.5 (a)
Resp18 16
Resp18 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Resp18 35
  • 74.17 (n)
  • 57.5 (a)
Species with no ortholog for RESP18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RESP18 Gene

ENSEMBL:
Gene Tree for RESP18 (if available)
TreeFam:
Gene Tree for RESP18 (if available)

Paralogs for RESP18 Gene

Selected SIMAP similar genes for RESP18 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RESP18: view

No data available for Paralogs for RESP18 Gene

Variants for RESP18 Gene

Sequence variations from dbSNP and Humsavar for RESP18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs908194 -- 219,333,525(-) TTAGC(C/T)AGTTA upstream-variant-2KB
rs1514748 -- 219,328,293(-) AAAGA(C/T)GAGGG intron-variant
rs1567931 -- 219,334,345(-) GGAAG(C/T)CCACC upstream-variant-2KB
rs1567932 -- 219,331,535(-) GAAAT(C/T)ATTAG intron-variant
rs1877867 -- 219,331,846(-) GAGGG(A/C)CGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RESP18 Gene

Variant ID Type Subtype PubMed ID
nsv834543 CNV Loss 17160897
nsv508885 CNV Insertion 20534489
nsv527936 CNV Loss 19592680
esv271296 CNV Insertion 20981092
esv272565 CNV Insertion 20981092

Relevant External Links for RESP18 Gene

HapMap Linkage Disequilibrium report
RESP18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RESP18 Gene

Disorders for RESP18 Gene

No disorders were found for RESP18 Gene.

No data available for UniProtKB/Swiss-Prot for RESP18 Gene

Publications for RESP18 Gene

  1. RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose. (PMID: 17951542) Zhang G. … Notkins A.L. (J. Endocrinol. 2007) 2 3 4 23
  2. Regulated endocrine-specific protein-18: a short-lived novel glucocorticoid-regulated endocrine protein. (PMID: 7988462) Bloomquist B.T. … Eipper B.A. (Endocrinology 1994) 2 3
  3. RESP18 is involved in the cytotoxicity of dopaminergic neurotoxins in MN9D cells. (PMID: 23319378) Huang Y. … Huang F. (Neurotox Res 2013) 3
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4
  5. Proteomic profiling in pancreatic cancer with and without lymph node metastasis. (PMID: 19152423) Cui Y. … Han J. (Int. J. Cancer 2009) 23

Products for RESP18 Gene

Sources for RESP18 Gene

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