Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RESP18 Gene

Aliases for RESP18 Gene

  • Regulated Endocrine-Specific Protein 18 2 3
  • Regulated Endocrine-Specific Protein 18 Homolog (Rat) 2

External Ids for RESP18 Gene

Previous GeneCards Identifiers for RESP18 Gene

  • GC02M220018
  • GC02M219900
  • GC02M220192
  • GC02M212045

Summaries for RESP18 Gene

GeneCards Summary for RESP18 Gene

RESP18 (Regulated Endocrine-Specific Protein 18) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RESP18 Gene

  • May play an important regulatory role in corticotrophs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RESP18 Gene

Genomics for RESP18 Gene

Regulatory Elements for RESP18 Gene

Genomic Location for RESP18 Gene

219,327,409 bp from pter
219,333,177 bp from pter
5,769 bases
Minus strand

Genomic View for RESP18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RESP18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RESP18 Gene

Proteins for RESP18 Gene

  • Protein details for RESP18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulated endocrine-specific protein 18
    Protein Accession:
    Secondary Accessions:
    • A8MQ49
    • Q38I23
    • Q5W5X0

    Protein attributes for RESP18 Gene

    173 amino acids
    Molecular mass:
    19021 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RESP18 Gene


neXtProt entry for RESP18 Gene

Proteomics data for RESP18 Gene at MOPED

Post-translational modifications for RESP18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RESP18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RESP18 Gene

Domains for RESP18 Gene

Protein Domains for RESP18 Gene


Suggested Antigen Peptide Sequences for RESP18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RESP18 family.
  • Belongs to the RESP18 family.
genes like me logo Genes that share domains with RESP18: view

No data available for Gene Families for RESP18 Gene

Function for RESP18 Gene

Molecular function for RESP18 Gene

UniProtKB/Swiss-Prot Function:
May play an important regulatory role in corticotrophs.

Phenotypes for RESP18 Gene

MGI mutant phenotypes for RESP18:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with RESP18: view

Animal Models for RESP18 Gene

MGI Knock Outs for RESP18:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for RESP18 Gene

Localization for RESP18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RESP18 Gene

Secreted. Endoplasmic reticulum. Golgi apparatus. Note=Found in the lumen of dense core vesicles (DCV). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RESP18 Gene COMPARTMENTS Subcellular localization image for RESP18 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
extracellular 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for RESP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum --
GO:0005794 Golgi apparatus IEA --
GO:0030141 secretory granule IEA --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with RESP18: view

Pathways for RESP18 Gene

SuperPathways for RESP18 Gene

No Data Available

Interacting Proteins for RESP18 Gene

Gene Ontology (GO) - Biological Process for RESP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
genes like me logo Genes that share ontologies with RESP18: view

No data available for Pathways by source for RESP18 Gene

Transcripts for RESP18 Gene

mRNA/cDNA for RESP18 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RESP18 Gene

Regulated endocrine-specific protein 18:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RESP18

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RESP18 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - -
SP2: - -
SP3: -

Relevant External Links for RESP18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RESP18 Gene

mRNA expression in normal human tissues for RESP18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RESP18 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (15.4), Brain - Putamen (basal ganglia) (13.1), and Brain - Caudate (basal ganglia) (12.5).

Protein differential expression in normal tissues for RESP18 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RESP18 Gene

SOURCE GeneReport for Unigene cluster for RESP18 Gene Hs.290551

mRNA Expression by UniProt/SwissProt for RESP18 Gene

Tissue specificity: Pancreas. Found in alpha, beta and delta cells in the pancreatic islets.
genes like me logo Genes that share expressions with RESP18: view

Expression partners for RESP18 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for RESP18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RESP18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RESP18 35
  • 81.12 (n)
  • 68.53 (a)
RESP18 36
  • 58 (a)
(Mus musculus)
Mammalia Resp18 35
  • 72.78 (n)
  • 57.5 (a)
Resp18 16
Resp18 36
  • 49 (a)
(Pan troglodytes)
Mammalia RESP18 35
  • 98.25 (n)
  • 95.18 (a)
RESP18 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Resp18 35
  • 74.17 (n)
  • 57.5 (a)
Species with no ortholog for RESP18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RESP18 Gene

Gene Tree for RESP18 (if available)
Gene Tree for RESP18 (if available)

Paralogs for RESP18 Gene

(1) SIMAP similar genes for RESP18 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RESP18: view

No data available for Paralogs for RESP18 Gene

Variants for RESP18 Gene

Sequence variations from dbSNP and Humsavar for RESP18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs572784703 -- 219,334,976(+) ATGTC(C/T)GGAAG upstream-variant-2KB
rs573156603 -- 219,332,888(+) AAGAA(C/T)CACCG intron-variant
rs573279465 -- 219,332,468(+) ACCCC(C/T)ACTTC intron-variant
rs573313844 -- 219,333,377(+) GTTTT(A/G)CCATG upstream-variant-2KB
rs572215232 -- 219,332,116(+) TGGAA(A/G)CCGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RESP18 Gene

Variant ID Type Subtype PubMed ID
nsv834543 CNV Loss 17160897
nsv508885 CNV Insertion 20534489
nsv527936 CNV Loss 19592680
esv271296 CNV Insertion 20981092
esv272565 CNV Insertion 20981092

Relevant External Links for RESP18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RESP18 Gene

Disorders for RESP18 Gene

No disorders were found for RESP18 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RESP18 Gene

Publications for RESP18 Gene

  1. RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose. (PMID: 17951542) Zhang G. … Notkins A.L. (J. Endocrinol. 2007) 2 3 4 23
  2. Regulated endocrine-specific protein-18: a short-lived novel glucocorticoid-regulated endocrine protein. (PMID: 7988462) Bloomquist B.T. … Eipper B.A. (Endocrinology 1994) 2 3
  3. Computational study for protein-protein docking using global optimization and empirical potentials. (PMID: 19325720) Lee K. (Int J Mol Sci 2008) 23
  4. Proteomic profiling in pancreatic cancer with and without lymph node metastasis. (PMID: 19152423) Cui Y. … Han J. (Int. J. Cancer 2009) 23
  5. Protein-protein interactions: hot spots and structurally conserved residues often locate in complemented pockets that pre-organized in the unbound states: implications for docking. (PMID: 15533445) Li X. … Liang J. (J. Mol. Biol. 2004) 23

Products for RESP18 Gene

Sources for RESP18 Gene

Back to Top