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Aliases for RERGL Gene

Aliases for RERGL Gene

  • RERG Like 2 3 5
  • RERG/RAS-Like 2 3
  • Ras-Related And Estrogen-Regulated Growth Inhibitor-Like Protein 3
  • RERG/Ras-Like Protein 4

External Ids for RERGL Gene

Previous GeneCards Identifiers for RERGL Gene

  • GC12M018126
  • GC12M018233

Summaries for RERGL Gene

GeneCards Summary for RERGL Gene

RERGL (RERG Like) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RERG.

UniProtKB/Swiss-Prot for RERGL Gene

  • Binds GDP/GTP and may possess intrinsic GTPase activity.

Additional gene information for RERGL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RERGL Gene

Genomics for RERGL Gene

Regulatory Elements for RERGL Gene

Enhancers for RERGL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H018258 0.9 ENCODE dbSUPER 11.1 +56.4 56410 9.4 SMARCE1 DPF2 NR2F2 YY1 ZNF217 CTBP1 JUND GATA3 ATF3 HNF4G RERGL PIK3C2G GC12M018263
GH12H018242 0.9 ENCODE 10.8 +77.4 77356 0.6 ELF3 PKNOX1 FOXA2 MLX RARA YY1 FOS MIXL1 HMG20B REST RERGL PIK3C2G PIR48236
GH12H018140 0.7 ENCODE 10.9 +178.8 178822 1.2 CTCF NFIB FEZF1 EP300 HIC1 JUND ZNF366 FOS CUX1 HNF4A RERGL PIK3C2G GC12M018127 PIR48236
GH12H018358 0.6 FANTOM5 11.3 -38.4 -38377 0.4 NFIC LCORL NFIB RERGL NDFIP1P1
GH12H018296 0.4 Ensembl 12.1 +23.3 23307 0.4 PRDM1 RERGL PIK3C2G GC12M018287
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RERGL on UCSC Golden Path with GeneCards custom track

Genomic Locations for RERGL Gene

Genomic Locations for RERGL Gene
239,239 bases
Minus strand

Genomic View for RERGL Gene

Genes around RERGL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RERGL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RERGL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RERGL Gene

Proteins for RERGL Gene

  • Protein details for RERGL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related and estrogen-regulated growth inhibitor-like protein
    Protein Accession:

    Protein attributes for RERGL Gene

    205 amino acids
    Molecular mass:
    23855 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RERGL Gene

Post-translational modifications for RERGL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RERGL Gene

No data available for DME Specific Peptides for RERGL Gene

Domains & Families for RERGL Gene

Gene Families for RERGL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RERGL Gene

Suggested Antigen Peptide Sequences for RERGL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Ras family.
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RERGL: view

Function for RERGL Gene

Molecular function for RERGL Gene

UniProtKB/Swiss-Prot Function:
Binds GDP/GTP and may possess intrinsic GTPase activity.

Gene Ontology (GO) - Molecular Function for RERGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RERGL: view

Phenotypes for RERGL Gene

genes like me logo Genes that share phenotypes with RERGL: view

miRNA for RERGL Gene

miRTarBase miRNAs that target RERGL

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RERGL Gene

Localization for RERGL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RERGL gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for RERGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RERGL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RERGL Gene

Pathways & Interactions for RERGL Gene

SuperPathways for RERGL Gene

No Data Available

Gene Ontology (GO) - Biological Process for RERGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RERGL: view

No data available for Pathways by source and SIGNOR curated interactions for RERGL Gene

Drugs & Compounds for RERGL Gene

No Compound Related Data Available

Transcripts for RERGL Gene

Unigene Clusters for RERGL Gene

Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RERGL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP2: -

Relevant External Links for RERGL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RERGL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RERGL Gene

mRNA differential expression in normal tissues according to GTEx for RERGL Gene

This gene is overexpressed in Artery - Tibial (x11.8).

NURSA nuclear receptor signaling pathways regulating expression of RERGL Gene:


SOURCE GeneReport for Unigene cluster for RERGL Gene:


Evidence on tissue expression from TISSUES for RERGL Gene

  • Nervous system(4.2)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with RERGL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RERGL Gene

Orthologs for RERGL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RERGL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RERGL 33 34
  • 99.64 (n)
(Canis familiaris)
Mammalia RERGL 33 34
  • 92.81 (n)
(Bos Taurus)
Mammalia RERGL 33 34
  • 91.18 (n)
(Mus musculus)
Mammalia Rergl 33 16 34
  • 85.29 (n)
(Rattus norvegicus)
Mammalia Rergl 33
  • 85.13 (n)
(Ornithorhynchus anatinus)
Mammalia RERGL 34
  • 66 (a)
(Gallus gallus)
Aves RERGL 33 34
  • 72.61 (n)
(Anolis carolinensis)
Reptilia RERGL 34
  • 70 (a)
(Danio rerio)
Actinopterygii rergla 33 34
  • 63.56 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008989 33
  • 48.29 (n)
(Caenorhabditis elegans)
Secernentea Y71F9AR.2 34
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHB1 34
  • 22 (a)
Species where no ortholog for RERGL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RERGL Gene

Gene Tree for RERGL (if available)
Gene Tree for RERGL (if available)

Paralogs for RERGL Gene

Paralogs for RERGL Gene

(14) SIMAP similar genes for RERGL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RERGL: view

Variants for RERGL Gene

Sequence variations from dbSNP and Humsavar for RERGL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs193920908 Uncertain significance 18,081,394(-) AAGGG(A/C)AAAAG nc-transcript-variant, reference, missense
rs1000406392 -- 18,086,590(+) TTTTG(C/T)TTTTT intron-variant
rs1000907824 -- 18,082,041(+) AGGCT(A/G)AGGCA intron-variant
rs1001029037 -- 18,083,708(+) TATTA(A/G)AAGTA intron-variant
rs1001408371 -- 18,088,417(+) TTTTT(A/C)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RERGL Gene

Variant ID Type Subtype PubMed ID
nsv625 CNV insertion 18451855
nsv557666 CNV loss 21841781
nsv557665 CNV loss 21841781
nsv1050900 CNV loss 25217958
nsv1038422 CNV loss 25217958
esv3892152 CNV gain 25118596
esv2761726 CNV loss 21179565
dgv1396n100 CNV loss 25217958

Variation tolerance for RERGL Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RERGL Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RERGL Gene

Disorders for RERGL Gene

Relevant External Links for RERGL

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RERGL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RERGL Gene

Publications for RERGL Gene

  1. Genome-wide analysis associates familial colorectal cancer with increases in copy number variations and a rare structural variation at 12p12.3. (PMID: 24127187) Yang R … Burwinkel B (Carcinogenesis 2014) 2 3 60
  2. Identification of genes related to Parkinson's disease using expressed sequence tags. (PMID: 17213182) Kim JM … Kim NS (DNA research : an international journal for rapid publication of reports on genes and genomes 2006) 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for RERGL Gene

Sources for RERGL Gene

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