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Aliases for RERGL Gene

Aliases for RERGL Gene

  • RERG Like 2 3 5
  • RERG/RAS-Like 2 3
  • Ras-Related And Estrogen-Regulated Growth Inhibitor-Like Protein 3
  • RERG/Ras-Like Protein 4

External Ids for RERGL Gene

Previous GeneCards Identifiers for RERGL Gene

  • GC12M018126
  • GC12M018233

Summaries for RERGL Gene

GeneCards Summary for RERGL Gene

RERGL (RERG Like) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RASL11A.

UniProtKB/Swiss-Prot for RERGL Gene

  • Binds GDP/GTP and may possess intrinsic GTPase activity.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RERGL Gene

Genomics for RERGL Gene

Regulatory Elements for RERGL Gene

Enhancers for RERGL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G018258 1 ENCODE dbSUPER 11.1 +56.4 56410 9.4 CTCF PKNOX1 RAD21 YY1 CTBP1 GATA3 HNF4G FOS DPF2 EP300 RERGL PIK3C2G GC12M018263
GH12G018242 0.9 ENCODE 10.8 +77.4 77356 0.6 ELF3 PKNOX1 FOXA2 MLX RARA YY1 GATA4 FOS MIXL1 HMG20B RERGL PIK3C2G PIR48236
GH12G018140 0.7 ENCODE 10.9 +178.8 178822 1.2 NFIB FEZF1 EP300 HIC1 JUND ZNF366 FOS CUX1 HNF4A TCF7L2 RERGL PIK3C2G GC12M018127 PIR48236
GH12G018358 0.5 FANTOM5 11.3 -38.4 -38377 0.4 NFIC NFIB RERGL NDFIP1P1
GH12G018296 0.4 Ensembl 12.1 +23.3 23307 0.4 PRDM1 RERGL PIK3C2G GC12M018287
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RERGL on UCSC Golden Path with GeneCards custom track

Genomic Location for RERGL Gene

Chromosome:
12
Start:
18,080,869 bp from pter
End:
18,320,107 bp from pter
Size:
239,239 bases
Orientation:
Minus strand

Genomic View for RERGL Gene

Genes around RERGL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RERGL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RERGL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RERGL Gene

Proteins for RERGL Gene

  • Protein details for RERGL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H628-RERGL_HUMAN
    Recommended name:
    Ras-related and estrogen-regulated growth inhibitor-like protein
    Protein Accession:
    Q9H628

    Protein attributes for RERGL Gene

    Size:
    205 amino acids
    Molecular mass:
    23855 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RERGL Gene

Post-translational modifications for RERGL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RERGL Gene

No data available for DME Specific Peptides for RERGL Gene

Domains & Families for RERGL Gene

Gene Families for RERGL Gene

Protein Domains for RERGL Gene

Suggested Antigen Peptide Sequences for RERGL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H628

UniProtKB/Swiss-Prot:

RERGL_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RERGL: view

Function for RERGL Gene

Molecular function for RERGL Gene

UniProtKB/Swiss-Prot Function:
Binds GDP/GTP and may possess intrinsic GTPase activity.

Gene Ontology (GO) - Molecular Function for RERGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RERGL: view

Phenotypes for RERGL Gene

genes like me logo Genes that share phenotypes with RERGL: view

Animal Model Products

CRISPR Products

miRNA for RERGL Gene

miRTarBase miRNAs that target RERGL

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RERGL Gene

Localization for RERGL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RERGL gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for RERGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RERGL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RERGL Gene

Pathways & Interactions for RERGL Gene

SuperPathways for RERGL Gene

No Data Available

Gene Ontology (GO) - Biological Process for RERGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RERGL: view

No data available for Pathways by source and SIGNOR curated interactions for RERGL Gene

Drugs & Compounds for RERGL Gene

No Compound Related Data Available

Transcripts for RERGL Gene

Unigene Clusters for RERGL Gene

RERG/RAS-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RERGL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -

Relevant External Links for RERGL Gene

GeneLoc Exon Structure for
RERGL
ECgene alternative splicing isoforms for
RERGL

Expression for RERGL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RERGL Gene

mRNA differential expression in normal tissues according to GTEx for RERGL Gene

This gene is overexpressed in Artery - Tibial (x11.8).

NURSA nuclear receptor signaling pathways regulating expression of RERGL Gene:

RERGL

SOURCE GeneReport for Unigene cluster for RERGL Gene:

Hs.732831

Evidence on tissue expression from TISSUES for RERGL Gene

  • Nervous system(4.2)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with RERGL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RERGL Gene

Orthologs for RERGL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RERGL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RERGL 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia RERGL 35 34
  • 92.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RERGL 34 35
  • 91.18 (n)
mouse
(Mus musculus)
Mammalia Rergl 16 35 34
  • 85.29 (n)
rat
(Rattus norvegicus)
Mammalia Rergl 34
  • 85.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RERGL 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves RERGL 34 35
  • 72.61 (n)
lizard
(Anolis carolinensis)
Reptilia RERGL 35
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rergla 34 35
  • 63.56 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008989 34
  • 48.29 (n)
worm
(Caenorhabditis elegans)
Secernentea Y71F9AR.2 35
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHB1 35
  • 22 (a)
OneToMany
Species where no ortholog for RERGL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RERGL Gene

ENSEMBL:
Gene Tree for RERGL (if available)
TreeFam:
Gene Tree for RERGL (if available)

Paralogs for RERGL Gene

Paralogs for RERGL Gene

(14) SIMAP similar genes for RERGL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RERGL: view

Variants for RERGL Gene

Sequence variations from dbSNP and Humsavar for RERGL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs193920908 Uncertain significance 18,081,394(-) AAGGG(A/C)AAAAG nc-transcript-variant, reference, missense
rs1000406392 -- 18,086,590(+) TTTTG(C/T)TTTTT intron-variant
rs1000907824 -- 18,082,041(+) AGGCT(A/G)AGGCA intron-variant
rs1001029037 -- 18,083,708(+) TATTA(A/G)AAGTA intron-variant
rs1001408371 -- 18,088,417(+) TTTTT(A/C)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RERGL Gene

Variant ID Type Subtype PubMed ID
dgv1396n100 CNV loss 25217958
esv2761726 CNV loss 21179565
esv3892152 CNV gain 25118596
nsv1038422 CNV loss 25217958
nsv1050900 CNV loss 25217958
nsv557665 CNV loss 21841781
nsv557666 CNV loss 21841781
nsv625 CNV insertion 18451855

Variation tolerance for RERGL Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RERGL Gene

Human Gene Mutation Database (HGMD)
RERGL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RERGL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RERGL Gene

Disorders for RERGL Gene

Relevant External Links for RERGL

Genetic Association Database (GAD)
RERGL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RERGL

No disorders were found for RERGL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RERGL Gene

Publications for RERGL Gene

  1. Genome-wide analysis associates familial colorectal cancer with increases in copy number variations and a rare structural variation at 12p12.3. (PMID: 24127187) Yang R. … Burwinkel B. (Carcinogenesis 2013) 2 3 64
  2. Identification of genes related to Parkinson's disease using expressed sequence tags. (PMID: 17213182) Kim J.M. … Kim N.S. (DNA Res. 2006) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for RERGL Gene

Sources for RERGL Gene

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