RERGL Gene
protein-coding GIFtS: 40
GCID: GC12M018233
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RERG/RAS-like
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Aliases
for RERGL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RERG/RAS-Like1 | | RERG/Ras-Like Protein2 3 | | FLJ226551 | | Ras-Related And Estrogen-Regulated Growth Inhibitor-Like Protein2 |
Export aliases for RERGL gene to outside databasesPrevious GC identifers: GC12M018126 GC12M018002 |
Summaries
for RERGL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RERGL_HUMAN, Q9H628Function: Binds GDP/GTP and may possess intrinsic GTPase activity (By similarity)
|
Genomic Views
for RERGL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RERGL gene promoter:
TBP Pbx1a Pax-2 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) Pax-2a POU3F2 Evi-1 CREB Pax-2b
Other transcription factors
Search SABiosciences Chromatin IP Primers for RERGL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RERGL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p12.3 Ensembl cytogenetic band: 12p12.3 HGNC cytogenetic band: 12p12.3RERGL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M018233: view genomic region
(about GC identifiers)
Start:
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18,233,803 bp from pter |
End:
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18,473,041 bp from pter |
Size:
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239,239 bases |
Orientation:
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minus strand |
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Proteins
for RERGL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RERGL_HUMAN, Q9H628 (See
protein sequence)Recommended Name: Ras-related and estrogen-regulated growth inhibitor-like protein Size: 205 amino acids; 23855 DaExplore the universe of human proteins at neXtProt for RERGL: NX_Q9H628
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H628
RERGL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079006.1
ENSEMBL proteins: ENSP00000229002 ENSP00000437814 ENSP00000437490
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- |
RERGL for ontologies About GeneDecksing
RERGL Antibody Products:
Assay Products for RERGL: |
Protein
Domains /
Families
for RERGL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RERGL for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H628ProtoNet protein and cluster: Q9H628 UniProtKB/Swiss-Prot: RERGL_HUMAN, Q9H628Similarity: Belongs to the small GTPase superfamily. Ras family |
Function
for RERGL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RERGL_HUMAN, Q9H628Function: Binds GDP/GTP and may possess intrinsic GTPase activity (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RERGL (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RERGL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RERGL (NM_024730) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RERGL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RERGL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RERGL |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RERGL for ontologies About GeneDecksing
|
Pathways & Interactions
for RERGL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RERGL
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- |
RERGL for ontologies About GeneDecksing
|
Drugs & Compounds
for RERGL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RERGL
1 HMDB Compound for RERGL About this table
Search CenterWatch for drugs/clinical trials and news about RERGL
|
Transcripts
for RERGL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RERGL gene: NM_024730.2 Unigene Cluster for RERGL: RERG/RAS-like Hs.732831 [show with all ESTs]Unigene Representative Sequence: BC0428885 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000229002(uc001rdq.3) ENST00000538724 ENST00000540148 ENST00000536890
ENST00000541632
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RERGL (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RERGL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RERGL (NM_024730) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RERGL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RERGL |
Additional cDNA sequence: AK026308.1 BC042888.1 4 DOTS entries: DT.100812811 DT.308617 DT.100720475 DT.308616 24/26 AceView cDNA sequences (see all 26): BX099150 BI324819 BI439784 BX422875 BC042888 AW779544 NM_024730 AW613961 AA436213 AK026308 CR618874 AA436212 BI753724 AI436755 CD250516 AI498375 CD110705 BQ941083 AI271862 BX483413 BM906091 AA220227 AA032154 BF947596
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for RERGL About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|
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| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for RERGL
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Expression
for RERGL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RERGL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCATAAAAAA
About this image
See RERGL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RERGL
SOURCE GeneReport for Unigene cluster: Hs.732831
SABiosciences Custom PCR Arrays for RERGL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RERGL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RERGL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RERGL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RERGL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RERGL |
Orthologs
for RERGL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RERGL gene from 4/18 species (see all 18) About this table
ENSEMBL Gene Tree for RERGL (if available)
TreeFam Gene Tree for RERGL (if available) |
Paralogs
for RERGL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RERGL gene
- RASL122 RASL11A2 RASL11B2 RERG2
14 SIMAP similar genes for RERGL using alignment to 3 protein entries: RERGL_HUMAN (see all proteins):RERG RAP1B c-bas/has RAP2A RASL11B RASL11A
DKFZp547A0616 RAP1A RAP2B MRAS RAP2C RIT1
RHEB RRAS2
RERGL for paralogs About GeneDecksing
|
Genomic Variants
for RERGL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RERGL (18233803 - 18473041 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RERGL: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RERGL |
|
Disorders
/ Diseases
for RERGL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RERGL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RERGL gene integrated from 9 sources:
(articles sorted by number of sources associating them with RERGL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for RERGL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RERGL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RERGL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RERGL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RERGL | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RERGL gene:
Search GeneIP for patents involving RERGL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RERGL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RERGL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RERGL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RERGL | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RERGL | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RERGL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RERGL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RERGL | | OriGene Custom Protein Services for RERGL | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RERGL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RERGL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RERGL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RERGL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RERGL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RERGL |
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 |  |  |  | |
| | | | Search Tocris compounds for RERGL |
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 | | | RERGL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RERGL |
|  |  |  | | | | Search ThermoFisher Antibodies for RERGL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RERGL |
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