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Aliases for RERGL Gene

Aliases for RERGL Gene

  • RERG/RAS-Like 2 3
  • RERG/Ras-Like Protein 4

External Ids for RERGL Gene

Previous GeneCards Identifiers for RERGL Gene

  • GC12M018126
  • GC12M018233

Summaries for RERGL Gene

GeneCards Summary for RERGL Gene

RERGL (RERG/RAS-Like) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot for RERGL Gene

  • Binds GDP/GTP and may possess intrinsic GTPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RERGL Gene

Genomics for RERGL Gene

Regulatory Elements for RERGL Gene

Genomic Location for RERGL Gene

Start:
18,080,869 bp from pter
End:
18,320,107 bp from pter
Size:
239,239 bases
Orientation:
Minus strand

Genomic View for RERGL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RERGL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RERGL Gene

Proteins for RERGL Gene

  • Protein details for RERGL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H628-RERGL_HUMAN
    Recommended name:
    Ras-related and estrogen-regulated growth inhibitor-like protein
    Protein Accession:
    Q9H628
    Secondary Accessions:

    Protein attributes for RERGL Gene

    Size:
    205 amino acids
    Molecular mass:
    23855 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RERGL Gene

Proteomics data for RERGL Gene at MOPED

Post-translational modifications for RERGL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RERGL Gene

No data available for DME Specific Peptides for RERGL Gene

Domains for RERGL Gene

Protein Domains for RERGL Gene

Suggested Antigen Peptide Sequences for RERGL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H628

UniProtKB/Swiss-Prot:

RERGL_HUMAN :
  • Q9H628
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RERGL: view

No data available for Gene Families for RERGL Gene

Function for RERGL Gene

Molecular function for RERGL Gene

UniProtKB/Swiss-Prot Function: Binds GDP/GTP and may possess intrinsic GTPase activity.

Gene Ontology (GO) - Molecular Function for RERGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RERGL: view

Animal Model Products

CRISPR Products

miRNA for RERGL Gene

miRTarBase miRNAs that target RERGL

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RERGL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RERGL Gene

Localization for RERGL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RERGL Gene COMPARTMENTS Subcellular localization image for RERGL gene
Compartment Confidence
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RERGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RERGL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RERGL Gene

Pathways for RERGL Gene

SuperPathways for RERGL Gene

No Data Available

Interacting Proteins for RERGL Gene

Gene Ontology (GO) - Biological Process for RERGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RERGL: view

No data available for Pathways by source for RERGL Gene

Compounds for RERGL Gene

(1) HMDB Compounds for RERGL Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RERGL: view

Transcripts for RERGL Gene

mRNA/cDNA for RERGL Gene

Unigene Clusters for RERGL Gene

RERG/RAS-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RERGL

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RERGL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RERGL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -

Relevant External Links for RERGL Gene

GeneLoc Exon Structure for
RERGL
ECgene alternative splicing isoforms for
RERGL

Expression for RERGL Gene

mRNA expression in normal human tissues for RERGL Gene

mRNA differential expression in normal tissues according to GTEx for RERGL Gene

This gene is overexpressed in Artery - Tibial (11.8).

SOURCE GeneReport for Unigene cluster for RERGL Gene Hs.732831

genes like me logo Genes that share expressions with RERGL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for RERGL Gene

Orthologs for RERGL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RERGL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RERGL 35
  • 99.64 (n)
  • 100 (a)
RERGL 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RERGL 35
  • 91.18 (n)
  • 93.63 (a)
RERGL 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RERGL 35
  • 92.81 (n)
  • 95.59 (a)
RERGL 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rergl 35
  • 85.29 (n)
  • 85.78 (a)
Rergl 16
Rergl 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RERGL 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rergl 35
  • 85.13 (n)
  • 85.29 (a)
chicken
(Gallus gallus)
Aves RERGL 35
  • 72.61 (n)
  • 74.26 (a)
RERGL 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RERGL 36
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rergla 35
  • 63.56 (n)
  • 65.2 (a)
rergla 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008989 35
  • 48.29 (n)
  • 42.31 (a)
worm
(Caenorhabditis elegans)
Secernentea Y71F9AR.2 36
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHB1 36
  • 22 (a)
OneToMany
Species with no ortholog for RERGL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RERGL Gene

ENSEMBL:
Gene Tree for RERGL (if available)
TreeFam:
Gene Tree for RERGL (if available)

Paralogs for RERGL Gene

Paralogs for RERGL Gene

Selected SIMAP similar genes for RERGL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RERGL: view

Variants for RERGL Gene

Sequence variations from dbSNP and Humsavar for RERGL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs941047 -- 18,081,163(+) TGATA(C/T)AGGAA utr-variant-3-prime, nc-transcript-variant
rs941048 - 18,081,322(+) CATCA(C/T)TTCCA reference, missense, nc-transcript-variant
rs1918067 -- 18,081,559(+) ACCAA(A/G)GGATT intron-variant
rs2069028 -- 18,087,539(-) TCCAC(C/T)TTGTA intron-variant
rs3054570 -- 18,081,542(+) aaaaa(-/AA)CAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RERGL Gene

Variant ID Type Subtype PubMed ID
nsv898837 CNV Gain 21882294
nsv898842 CNV Loss 21882294
nsv625 CNV Insertion 18451855

Relevant External Links for RERGL Gene

HapMap Linkage Disequilibrium report
RERGL
Human Gene Mutation Database (HGMD)
RERGL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RERGL Gene

Disorders for RERGL Gene

Relevant External Links for RERGL

Genetic Association Database (GAD)
RERGL
genes like me logo Genes that share disorders with RERGL: view

No data available for UniProtKB/Swiss-Prot for RERGL Gene

Publications for RERGL Gene

  1. Genome-wide analysis associates familial colorectal cancer with increases in copy number variations and a rare structural variation at 12p12.3. (PMID: 24127187) Yang R. … Burwinkel B. (Carcinogenesis 2013) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy. (PMID: 9628821) Claudio J.O. … Hawley R.G. (Genomics 1998) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RERGL Gene

Sources for RERGL Gene

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