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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RERGL Gene

protein-coding   GIFtS: 42
GCID: GC12M018233

RERG/RAS-Like

  Search for RERGL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RERG/RAS-like1 2
RERG/Ras-Like Protein2 3
Ras-Related And Estrogen-Regulated Growth Inhibitor-Like Protein2

External Ids:    HGNC: 262131   Entrez Gene: 797852   Ensembl: ENSG000001114047   UniProtKB: Q9H6283   

Export aliases for RERGL gene to outside databases

Previous GC identifers: GC12M018126 GC12M018002


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RERGL Gene: 
RERGL (RERG/RAS-like) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot: RERGL_HUMAN, Q9H628
Function: Binds GDP/GTP and may possess intrinsic GTPase activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RERGL gene promoter:
         TBP   Pbx1a   Pax-2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Pax-2a   POU3F2   Evi-1   CREB   Pax-2b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRERGL promoter sequence
   Search SABiosciences Chromatin IP Primers for RERGL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RERGL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3

RERGL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RERGL gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M018233:  view genomic region     (about GC identifiers)

Start:
18,233,803 bp from pter      End:
18,473,041 bp from pter
Size:
239,239 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RERGL_HUMAN, Q9H628 (See protein sequence)
Recommended Name: Ras-related and estrogen-regulated growth inhibitor-like protein  
Size: 205 amino acids; 23855 Da

Explore the universe of human proteins at neXtProt for RERGL: NX_Q9H628

Explore proteomics data for RERGL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H628

  • RERGL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RERGL Protein Expression
    REFSEQ proteins: NP_079006.1  
    ENSEMBL proteins: 
     ENSP00000229002   ENSP00000437814   ENSP00000437490  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0016020membrane IEA--

    RERGL for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q9H628

    ProtoNet protein and cluster: Q9H628

    UniProtKB/Swiss-Prot: RERGL_HUMAN, Q9H628
    Similarity: Belongs to the small GTPase superfamily. Ras family


    RERGL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RERGL_HUMAN, Q9H628
    Function: Binds GDP/GTP and may possess intrinsic GTPase activity (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--
         
    RERGL for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RERGL

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    RERGL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RERGL

    1 HMDB Compound for RERGL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RERGL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for RERGL gene: 
    NM_024730.2  

    Unigene Cluster for RERGL:

    RERG/RAS-like
    Hs.732831  [show with all ESTs]
    Unigene Representative Sequence: BC042888
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229002(uc001rdq.3) ENST00000538724 ENST00000540148 ENST00000536890
    ENST00000541632
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK026308.1 BC042888.1 

    4 DOTS entries:

    DT.100812811  DT.308617  DT.100720475  DT.308616 

    24/26 AceView cDNA sequences (see all 26):

    BX099150 BI439784 BC042888 AW779544 AW613961 NM_024730 AK026308 BI324819 
    AA436213 BX422875 CR618874 AA436212 BQ941083 AI436755 BM906091 AI498375 
    CD250516 CD110705 BI753724 AI271862 BX483413 AA032154 AA220227 BF947596 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RERGL    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                          
    SP2:        -                                 


    ECgene alternative splicing isoforms for RERGL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RERGL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCATAAAAAA
    RERGL Expression
    About this image


    See RERGL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RERGL

    SOURCE GeneReport for Unigene cluster: Hs.732831
        SABiosciences Custom PCR Arrays for RERGL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RERGL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RERGL gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rergl1 , 5 RERG/RAS-like1, 5 85.56(n)1
    86.1(a)1
      6 (69.67 cM)5
    6329711  NM_001128090.11  NP_001121562.11 
     1394931825 
    chicken
    (Gallus gallus)
    Aves RERGL1 RERG/RAS-like 73.15(n)
    74.05(a)
      418180  XM_416411.3  XP_416411.1 
    lizard
    (Anolis carolinensis)
    Reptilia RERGL6
    Uncharacterized protein
    70(a)
    1 ↔ 1
    5(9911741-9920486)
    zebrafish
    (Danio rerio)
    Actinopterygii rergla1 RERG/RAS-like a 63.64(n)
    64.17(a)
      436767  NM_001002494.1  NP_001002494.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG85196
    --
    27(a)
    1 → many
    3L(6697960-6702100)


    ENSEMBL Gene Tree for RERGL (if available)
    TreeFam Gene Tree for RERGL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RERGL gene
    RASL122  RASL11A2  RHEB2  RASL11B2  RHEBL12  RERG2  
    14 SIMAP similar genes for RERGL using alignment to 3 protein entries:     RERGL_HUMAN (see all proteins):
    RERG    RAP1B    c-bas/has    RAP2A    RASL11B    RASL11A
    DKFZp547A0616    RAP1A    RAP2B    MRAS    RAP2C    RIT1
    RHEB    RRAS2

    RERGL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/302 SNPs in RERGL are shown (see all 302)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1891393411,2
    --18233378(+) AAAAAA/GGCCTT 1 -- int10--------
    rs79589611,2
    C,F,A,H--18233402(+) TCCCCG/AATAAG 1 -- int19Minor allele frequency- A:0.35NS EA WA CSA NA 627
    rs1808427611,2
    --18233472(+) CCTTAA/GCTCTA 1 -- int10--------
    rs1170567271,2
    F--18233538(+) GAAGAG/ATAGAC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1845962611,2
    --18234008(+) CATTTC/TATATC 1 -- ut310--------
    rs121468651,2
    C,F,H--18234021(+) CAAGAG/TAATTC 1 -- ut31 ese36Minor allele frequency- T:0.02NS EA WA NA 622
    rs9410471,2
    C,F,O,A,H--18234097(+) TGATAT/CAGGAA 1 -- ut31 ese319Minor allele frequency- C:0.08MN NA NS EA CSA EU 3187
    rs714610871,2
    C,F--18234108(+) ATCTCC/TCAGGA 1 -- ut313Minor allele frequency- T:0.01NA EU 1261
    rs1442972801,2
    C--18234134(+) ACAGAA/TTTCCT 2 K N mis10--------
    rs2001946581,2
    --18234150(+) TTCCAA/CATACA 2 C F mis10--------

    HapMap Linkage Disequilibrium report for RERGL (18233803 - 18473041 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RERGL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv625CNV Insertion18451855
    nsv898842CNV Loss21882294
    nsv898837CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RERGL for disorders           About MalaCards

    RERGL for disorders           About GeneDecksing

    Genetic Association Database (GAD): RERGL

    Export disorders for RERGL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RERGL gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RERGL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79785 HGNC: 26213 AceView: FLJ22655 Ensembl:ENSG00000111404 euGenes: HUgn79785
    ECgene: RERGL H-InvDB: RERGL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RERGL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RERGL gene:
    Search GeneIP for patents involving RERGL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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