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RERGL Gene

protein-coding   GIFtS: 42
GCID: GC12M018233

RERG/RAS-Like

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RERG/RAS-like1 2
Ras-Related And Estrogen-Regulated Growth Inhibitor-Like Protein2
RERG/Ras-Like Protein3

External Ids:    HGNC: 262131   Entrez Gene: 797852   Ensembl: ENSG000001114047   UniProtKB: Q9H6283   

Export aliases for RERGL gene to outside databases

Previous GC identifers: GC12M018126 GC12M018002


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RERGL Gene:
RERGL (RERG/RAS-like) is a protein-coding gene. Diseases associated with RERGL include malaria. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot: RERGL_HUMAN, Q9H628
Function: Binds GDP/GTP and may possess intrinsic GTPase activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RERGL gene promoter:
         TBP   Pbx1a   Pax-2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Pax-2a   POU3F2   Evi-1   CREB   Pax-2b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRERGL promoter sequence
   Search Chromatin IP Primers for RERGL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RERGL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3

RERGL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RERGL gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M018233:  view genomic region     (about GC identifiers)

Start:
18,233,803 bp from pter      End:
18,473,041 bp from pter
Size:
239,239 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RERGL_HUMAN, Q9H628 (See protein sequence)
Recommended Name: Ras-related and estrogen-regulated growth inhibitor-like protein  
Size: 205 amino acids; 23855 Da

Explore the universe of human proteins at neXtProt for RERGL: NX_Q9H628

Explore proteomics data for RERGL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RERGL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273130.1  NP_079006.1  

    ENSEMBL proteins: 
     ENSP00000229002   ENSP00000437814   ENSP00000437490  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q9H628

    ProtoNet protein and cluster: Q9H628

    UniProtKB/Swiss-Prot: RERGL_HUMAN, Q9H628
    Similarity: Belongs to the small GTPase superfamily. Ras family


    RERGL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RERGL_HUMAN, Q9H628
    Function: Binds GDP/GTP and may possess intrinsic GTPase activity (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IEA--
         
    RERGL for ontologies           About GeneDecksing


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    hsa-mir-335-5p (MIRT019120)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0016020membrane IEA--

    RERGL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RERGL
    Interactions:

        Search GeneGlobe Interaction Network for RERGL

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RERGL (ENSP000002290024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3DENSP000002161904STRING: ENSP00000216190
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IEA--
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    RERGL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RERGL

    1 HMDB Compound for RERGL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RERGL gene (2 alternative transcripts): 
    NM_001286201.1  NM_024730.3  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229002(uc001rdq.3) ENST00000538724 ENST00000540148 ENST00000536890
    ENST00000541632
    miRNA
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    Selected AceView cDNA sequences (see all 26):

    BI324819 AW779544 BX099150 AA436213 AW613961 NM_024730 AK026308 BI439784 
    CR618874 BX422875 BC042888 AI436755 AI498375 AI271862 BQ941083 BI753724 
    CD110705 BX483413 BM906091 CD250516 AA436212 BF947596 AA032154 AA220227 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RERGL    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                          
    SP2:        -                                 


    ECgene alternative splicing isoforms for RERGL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RERGL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCATAAAAAA
    RERGL Expression
    About this image

    RERGL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RERGL Protein Expression
        Custom PCR Arrays for RERGL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RERGL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RERGL gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rergl1 , 5 RERG/RAS-like1, 5 85.29(n)1
    85.78(a)1
      6 (69.67 cM)5
    6329711  NM_001128090.11  NP_001121562.11 
     1394931825 
    chicken
    (Gallus gallus)
    Aves RERGL1 RERG/RAS-like 72.61(n)
    74.26(a)
      418180  XM_416411.4  XP_416411.1 
    lizard
    (Anolis carolinensis)
    Reptilia RERGL6
    RERG/RAS-like
    70(a)
    1 ↔ 1
    5(9911741-9920486)
    zebrafish
    (Danio rerio)
    Actinopterygii rergla1 RERG/RAS-like a 63.56(n)
    65.2(a)
      436767  NM_001002494.1  NP_001002494.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0089891 AgaP_AGAP008989 48.29(n)
    42.31(a)
      1279951  XM_319739.3  XP_319739.3 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71F9AR.26
    Protein Y71F9AR.2 (Y71F9AR.2) mRNA, complete cds
    22(a)
    1 → many
    I(2983263-2985167) WBGene00022123
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RHB16
    Putative Rheb-related GTPase involved in regulatin...
    22(a)
    1 → many
    III(167370-167999) YCR027C


    ENSEMBL Gene Tree for RERGL (if available)
    TreeFam Gene Tree for RERGL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RERGL gene
    RASL122  RASL11A2  RHEB2  RASL11B2  RHEBL12  RERG2  
    14 SIMAP similar genes for RERGL using alignment to 3 protein entries:     RERGL_HUMAN (see all proteins):
    RERG    RAP1B    c-bas/has    RAP2A    RASL11B    RASL11A
    DKFZp547A0616    RAP1A    RAP2B    MRAS    RAP2C    RIT1
    RHEB    RRAS2

    RERGL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RERGL (see all 302)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1891393411,2
    --18233378(+) AAAAAA/GGCCTT 1 -- int10--------
    rs79589611,2
    C,F,A,H--18233402(+) TCCCCG/AATAAG 1 -- int19Minor allele frequency- A:0.35NS EA WA CSA NA 627
    rs1808427611,2
    --18233472(+) CCTTAA/GCTCTA 1 -- int10--------
    rs1170567271,2
    F--18233538(+) GAAGAG/ATAGAC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1845962611,2
    --18234008(+) CATTTC/TATATC 1 -- ut310--------
    rs121468651,2
    C,F,H--18234021(+) CAAGAG/TAATTC 1 -- ut31 ese36Minor allele frequency- T:0.02NS EA WA NA 622
    rs9410471,2
    C,F,O,A,H--18234097(+) TGATAT/CAGGAA 1 -- ut31 ese319Minor allele frequency- C:0.08MN NA NS EA CSA EU 3187
    rs714610871,2
    C,F--18234108(+) ATCTCC/TCAGGA 1 -- ut313Minor allele frequency- T:0.01NA EU 1261
    rs1442972801,2
    C--18234134(+) ACAGAA/TTTCCT 2 K N mis10--------
    rs2001946581,2
    --18234150(+) TTCCAA/CATACA 2 C F mis10--------

    HapMap Linkage Disequilibrium report for RERGL (18233803 - 18473041 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RERGL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv625CNV Insertion18451855
    nsv898842CNV Loss21882294
    nsv898837CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for RERGL:    
    About MalaCards
    malaria


    RERGL for disorders           About GeneDecksing

    Genetic Association Database (GAD): RERGL

    Export disorders for RERGL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RERGL gene integrated from 10 sources:
    (articles sorted by number of sources associating them with RERGL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Identification of genes related to Parkinson's disease using expressed sequence tags. (PubMed id 17213182)1 Kim J.M.... Kim N.S. (DNA Res. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy. (PubMed id 9628821)1 Claudio J.O....Hawley R.G. (Genomics 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79785 HGNC: 26213 AceView: FLJ22655 Ensembl:ENSG00000111404 euGenes: HUgn79785
    ECgene: RERGL H-InvDB: RERGL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RERGL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RERGL gene:
    Search GeneIP for patents involving RERGL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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