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Aliases for RERGL Gene

Aliases for RERGL Gene

  • RERG Like 2 3
  • RERG/RAS-Like 2 3 5
  • RERG/Ras-Like Protein 4

External Ids for RERGL Gene

Previous GeneCards Identifiers for RERGL Gene

  • GC12M018126
  • GC12M018233

Summaries for RERGL Gene

GeneCards Summary for RERGL Gene

RERGL (RERG Like) is a Protein Coding gene. Diseases associated with RERGL include Familial Colorectal Cancer. GO annotations related to this gene include GTP binding. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot for RERGL Gene

  • Binds GDP/GTP and may possess intrinsic GTPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RERGL Gene

Genomics for RERGL Gene

Regulatory Elements for RERGL Gene

Enhancers for RERGL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RERGL on UCSC Golden Path with GeneCards custom track

Genomic Location for RERGL Gene

18,080,869 bp from pter
18,320,107 bp from pter
239,239 bases
Minus strand

Genomic View for RERGL Gene

Genes around RERGL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RERGL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RERGL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RERGL Gene

Proteins for RERGL Gene

  • Protein details for RERGL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related and estrogen-regulated growth inhibitor-like protein
    Protein Accession:

    Protein attributes for RERGL Gene

    205 amino acids
    Molecular mass:
    23855 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RERGL Gene

Proteomics data for RERGL Gene at MOPED

Post-translational modifications for RERGL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RERGL Gene

No data available for DME Specific Peptides for RERGL Gene

Domains & Families for RERGL Gene

Gene Families for RERGL Gene

Protein Domains for RERGL Gene

Suggested Antigen Peptide Sequences for RERGL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Ras family.
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RERGL: view

Function for RERGL Gene

Molecular function for RERGL Gene

UniProtKB/Swiss-Prot Function:
Binds GDP/GTP and may possess intrinsic GTPase activity.

Phenotypes for RERGL Gene

genes like me logo Genes that share phenotypes with RERGL: view

Animal Model Products

miRNA for RERGL Gene

miRTarBase miRNAs that target RERGL

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RERGL Gene

Localization for RERGL Gene

Subcellular locations from

Jensen Localization Image for RERGL Gene COMPARTMENTS Subcellular localization image for RERGL gene
Compartment Confidence
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RERGL Gene

Pathways & Interactions for RERGL Gene

SuperPathways for RERGL Gene

No Data Available

Interacting Proteins for RERGL Gene

Gene Ontology (GO) - Biological Process for RERGL Gene


No data available for Pathways by source and SIGNOR curated interactions for RERGL Gene

Drugs & Compounds for RERGL Gene

No Compound Related Data Available

Transcripts for RERGL Gene

Unigene Clusters for RERGL Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RERGL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP2: -

Relevant External Links for RERGL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RERGL Gene

mRNA expression in normal human tissues for RERGL Gene

mRNA differential expression in normal tissues according to GTEx for RERGL Gene

This gene is overexpressed in Artery - Tibial (x11.8).

SOURCE GeneReport for Unigene cluster for RERGL Gene Hs.732831

genes like me logo Genes that share expression patterns with RERGL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RERGL Gene

Orthologs for RERGL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RERGL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RERGL 35
  • 91.18 (n)
  • 93.63 (a)
  • 87 (a)
(Canis familiaris)
Mammalia RERGL 35
  • 92.81 (n)
  • 95.59 (a)
  • 82 (a)
(Mus musculus)
Mammalia Rergl 35
  • 85.29 (n)
  • 85.78 (a)
Rergl 16
Rergl 36
  • 80 (a)
(Pan troglodytes)
Mammalia RERGL 35
  • 99.64 (n)
  • 100 (a)
  • 93 (a)
(Rattus norvegicus)
Mammalia Rergl 35
  • 85.13 (n)
  • 85.29 (a)
(Ornithorhynchus anatinus)
Mammalia RERGL 36
  • 66 (a)
(Gallus gallus)
Aves RERGL 35
  • 72.61 (n)
  • 74.26 (a)
  • 69 (a)
(Anolis carolinensis)
Reptilia RERGL 36
  • 70 (a)
(Danio rerio)
Actinopterygii rergla 35
  • 63.56 (n)
  • 65.2 (a)
rergla 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008989 35
  • 48.29 (n)
  • 42.31 (a)
(Caenorhabditis elegans)
Secernentea Y71F9AR.2 36
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHB1 36
  • 22 (a)
Species with no ortholog for RERGL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RERGL Gene

Gene Tree for RERGL (if available)
Gene Tree for RERGL (if available)

Paralogs for RERGL Gene

Paralogs for RERGL Gene

(14) SIMAP similar genes for RERGL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RERGL: view

Variants for RERGL Gene

Sequence variations from dbSNP and Humsavar for RERGL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs941048 - 18,081,322(+) CATCA(C/T)TTCCA nc-transcript-variant, reference, missense
rs2069028 -- 18,087,539(-) TCCAC(C/T)TTGTA intron-variant
rs12823067 -- 18,081,590(+) TATTG(G/T)GTGTA intron-variant
rs16913781 -- 18,087,887(+) TTTCT(A/G)TAATC intron-variant
rs11043839 -- 18,081,488(+) AGATA(A/C/G)ACAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RERGL Gene

Variant ID Type Subtype PubMed ID
nsv898837 CNV Gain 21882294
nsv898842 CNV Loss 21882294
nsv625 CNV Insertion 18451855

Variation tolerance for RERGL Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RERGL Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RERGL Gene

Disorders for RERGL Gene

MalaCards: The human disease database

(1) MalaCards diseases for RERGL Gene - From: GeneCards

Disorder Aliases PubMed IDs
familial colorectal cancer
  • colorectal cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search RERGL in MalaCards View complete list of genes associated with diseases

Relevant External Links for RERGL

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RERGL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RERGL Gene

Publications for RERGL Gene

  1. Genome-wide analysis associates familial colorectal cancer with increases in copy number variations and a rare structural variation at 12p12.3. (PMID: 24127187) Yang R. … Burwinkel B. (Carcinogenesis 2013) 2 3 67
  2. Identification of genes related to Parkinson's disease using expressed sequence tags. (PMID: 17213182) Kim J.M. … Kim N.S. (DNA Res. 2006) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy. (PMID: 9628821) Claudio J.O. … Hawley R.G. (Genomics 1998) 3

Products for RERGL Gene

Sources for RERGL Gene