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RERG Gene

protein-coding   GIFtS: 53
GCID: GC12M015160

RAS-Like, Estrogen-Regulated, Growth Inhibitor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAS-Like, Estrogen-Regulated, Growth Inhibitor1 2
Ras-Related And Estrogen-Regulated Growth Inhibitor2

External Ids:    HGNC: 159801   Entrez Gene: 850042   Ensembl: ENSG000001345337   OMIM: 6126645   UniProtKB: Q96A583   

Export aliases for RERG gene to outside databases

Previous GC identifers: GC12M015000 GC12M015405 GC12M015151


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RERG Gene:
RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al.,
2001 (PubMed 11533059)).(supplied by OMIM, Mar 2009)

GeneCards Summary for RERG Gene:
RERG (RAS-like, estrogen-regulated, growth inhibitor) is a protein-coding gene. Diseases associated with RERG include functioning pituitary adenoma, and pituitary adenoma. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot: RERG_HUMAN, Q96A58
Function: Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell
lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic
potential




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the RERG gene promoter:
         AML1a   Lmo2   Nkx2-5   POU3F2   Meis-1b   POU2F1   COMP1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRERG promoter sequence
   Search Chromatin IP Primers for RERG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RERG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p13.1

RERG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RERG gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M015160:  view genomic region     (about GC identifiers)

Start:
15,260,716 bp from pter      End:
15,501,609 bp from pter
Size:
240,894 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RERG_HUMAN, Q96A58 (See protein sequence)
Recommended Name: Ras-related and estrogen-regulated growth inhibitor  
Size: 199 amino acids; 22608 Da
1 PDB 3D structure from and Proteopedia for RERG:
2ATV (3D)    
Secondary accessions: B2R9R0 B4DI02
Alternative splicing: 2 isoforms:  Q96A58-1   Q96A58-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RERG: NX_Q96A58

Explore proteomics data for RERG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RERG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177655.1  NP_116307.1  

    ENSEMBL proteins: 
     ENSP00000256953   ENSP00000441505   ENSP00000438280   ENSP00000444485   ENSP00000439532  
     ENSP00000441860   ENSP00000440887  

    RERG Human Recombinant Protein Products:

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    Novus Biologicals RERG Proteins
    Novus Biologicals RERG Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RERG
    Cloud-Clone Corp. Proteins for RERG

    RERG Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for RERG

    RERG Assay Products:

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    Cloud-Clone Corp. CLIAs for RERG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q96A58

    ProtoNet protein and cluster: Q96A58

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RERG_HUMAN, Q96A58
    Similarity: Belongs to the small GTPase superfamily. Ras family


    RERG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RERG_HUMAN, Q96A58
    Function: Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell
    lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic
    potential
    Induction: Up-regulated by estradiol. Down-regulated by tamoxifen

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA11533059
    GO:0005525GTP binding IEA--
    GO:0019003GDP binding TAS11533059
    GO:0030331estrogen receptor binding NAS11533059
         
    RERG for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RERG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RERG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RERG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RERG

    miRNA
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    miRTarBase miRNAs that target RERG:
    hsa-mir-335-5p (MIRT017557)

    Block miRNA regulation of human, mouse, rat RERG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RERG (see all 20):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-379* hsa-miR-520d-5p hsa-miR-4299 hsa-miR-340 hsa-miR-105 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidRERG 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RERG
    Predesigned siRNA for gene silencing in human, mouse, rat RERG

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for RERG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RERG (NM_024730)
    Sino Biological Human cDNA Clone for RERG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RERG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RERG

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RERG 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RERG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RERG_HUMAN, Q96A58: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA11533059
    GO:0005737cytoplasm ----
    GO:0005829cytosol IDA11533059
    GO:0016020membrane IEA--

    RERG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RERG
    Interactions:

        Search GeneGlobe Interaction Network for RERG

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RERG (ENSP000002569534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3DENSP000002161904STRING: ENSP00000216190
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction NAS11533059
    GO:0008285negative regulation of cell proliferation IDA11533059
    GO:0009725response to hormone IDA11533059

    RERG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RERG

    1 HMDB Compound for RERG    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 Novoseek inferred chemical compound relationships for RERG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 69 7 16757349 (1), 18374156 (1), 11533059 (1)
    gtp 58.9 14 16757349 (2), 18374156 (2), 11533059 (2)
    estrogen 40.1 11 11533059 (3), 16757349 (2), 18374156 (2)



    RERG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RERG gene (2 alternative transcripts): 
    NM_001190726.1  NM_032918.2  

    Unigene Cluster for RERG:

    RAS-like, estrogen-regulated, growth inhibitor
    Hs.199487  [show with all ESTs]
    Unigene Representative Sequence: NM_032918
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256953(uc001rct.3 uc010shu.2) ENST00000538313(uc001rcs.3)
    ENST00000536465 ENST00000546331 ENST00000545567 ENST00000537647 ENST00000393736
    ENST00000537717 ENST00000437578
    miRNA
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    Block miRNA regulation of human, mouse, rat RERG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RERG (see all 20):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-379* hsa-miR-520d-5p hsa-miR-4299 hsa-miR-340 hsa-miR-105 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidRERG 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RERG
    Predesigned siRNA for gene silencing in human, mouse, rat RERG
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RERG (NM_024730)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RERG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RERG
    Primer
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    OriGene qPCR primer pairs and template standards for RERG
    OriGene qSTAR qPCR primer pairs in human, mouse for RERG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RERG
      QuantiTect SYBR Green Assays in human, mouse, rat RERG
      QuantiFast Probe-based Assays in human, mouse, rat RERG

    Additional mRNA sequence: 

    AF339750.1 AK295343.1 AK311016.1 AK313881.1 BC007997.1 

    6 DOTS entries:

    DT.444193  DT.100776638  DT.100776640  DT.100776639  DT.121141861  DT.75188081 

    Selected AceView cDNA sequences (see all 113):

    BX439115 AA564698 AA437054 BX645101 BX335508 BX404162 AA742672 CR614972 
    NM_032918 CR599509 BX398732 CR614290 BI758132 AA037415 BX335509 BX358427 
    CD516953 BE550363 D79915 F00427 BI521260 BC007997 BG900183 BU632135 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RERG (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                          -     -           -     -                 -     -                                 
    SP2:                          -     -           -     -                 -                                       
    SP3:                                -           -     -                 -     -                                 
    SP4:                          -     -           -     -                                                         
    SP5:                                            -     -                 -     -                                 


    ECgene alternative splicing isoforms for RERG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RERG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTATTTTG
    RERG Expression
    About this image


    RERG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
    RERG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RERG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.199487

    UniProtKB/Swiss-Prot: RERG_HUMAN, Q96A58
    Tissue specificity: Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in
    estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines.
    Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis

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    QuantiFast Probe-based Assays in human, mouse, rat RERG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RERG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RERG gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rerg1 , 5 RAS-like, estrogen-regulated, growth-inhibitor1, 5 88.11(n)1
    98.49(a)1
      6 (66.73 cM)5
    2324411  NM_181988.21  NP_871788.11 
     1370548255 
    chicken
    (Gallus gallus)
    Aves RERG1 RAS-like, estrogen-regulated, growth inhibitor 81.57(n)
    95.98(a)
      418173  XM_004937961.1  XP_004938018.1 
    lizard
    (Anolis carolinensis)
    Reptilia RERG6
    RAS-like, estrogen-regulated, growth inhibitor
    86(a)
    1 ↔ 1
    5(14782085-14793565)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rerg1 RAS-like, estrogen-regulated, growth inhibitor 78.22(n)
    89.45(a)
      100134997  NM_001113676.1  NP_001107148.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018821041 ras-related and estrogen-regulated growth inhibitor-like 72.36(n)
    80.9(a)
      101882104  XM_005168501.1  XP_005168558.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51606
    --
    23(a)
    1 ↔ 1
    2L(7390984-7398403)


    ENSEMBL Gene Tree for RERG (if available)
    TreeFam Gene Tree for RERG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RERG gene
    RASL122  RASL11A2  RERGL2  RHEB2  RASL11B2  RHEBL12  
    Selected SIMAP similar genes for RERG using alignment to 4 protein entries:     RERG_HUMAN (see all proteins) (see all similar genes):
    K-RAS    c-bas/has    RRAS2    KRAS    RIT2    RAP1B
    RALB    RALA    RAP2A    DKFZp547A0616    RAP2B    RIT1
    MRAS    RAP2C    RAP1A    RERGL    HRAS    NRAS

    RERG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RERG (see all 2053)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105540931,2
    C--15041302(+) CACAC-/TCATATA 2 -- int11Minor allele frequency- TC:0.00NA 2
    rs763296961,2
    F--15260371(+) CGAGGT/ACTGGA 2 -- ds50011Minor allele frequency- A:0.05WA 118
    rs104921681,2
    C,F,H--15260563(-) TTTAGG/ATGCTA 2 -- ds500188Minor allele frequency- A:0.02NS EA PA EU CA WA NA 4590
    rs73068001,2
    C,F,A,H--15260636(+) TGTCAA/GTTTTG 2 -- ds500121Minor allele frequency- G:0.12NS EA NA WA 2548
    rs1396052261,2
    --15260677(+) AAATTA/GTAAAT 2 -- ds50010--------
    rs1434210801,2
    --15260714(+) CCCAAA/GTATGA 2 -- ds50010--------
    rs1511949541,2
    C--15260782(+) AAGTTA/GTCCAA 2 -- ut310--------
    rs1829407301,2
    C--15260809(+) ATGCCA/GCTAAC 2 -- ut310--------
    rs1456988651,2
    C--15260984(+) ATACA-/AGAGAGT 2 -- ut310--------
    rs10457331,2
    C,F,O,H--15260993(-) CTAAAA/GCAGAC 2 -- ut3118Minor allele frequency- G:0.12MN NA NS EA WA 1514

    HapMap Linkage Disequilibrium report for RERG (15260716 - 15501609 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RERG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv619CNV Insertion18451855
    nsv620CNV Insertion18451855
    nsv898819CNV Loss21882294
    nsv898820CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RERG
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612664    OMIM disorders: --

    10 diseases for RERG:    
    About MalaCards
    functioning pituitary adenoma    pituitary adenoma    lung cancer susceptibility    adenoma
    breast cancer    hepatocellular carcinoma    lung cancer    malaria
    endotheliitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for RERG:
    Pituitary carcinoma

    RERG for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for RERG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast carcinoma 45 4 16757349 (1), 11533059 (1)
    breast cancer 30.1 11 18374156 (5), 17043425 (1), 11533059 (1)
    tumors 14.2 11 16757349 (4), 11533059 (3), 17043425 (2), 18374156 (1)

    Genetic Association Database (GAD): RERG
    Human Genome Epidemiology (HuGE) Navigator: RERG (4 documents)

    Export disorders for RERG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RERG gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with RERG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. (PubMed id 11533059)1, 2, 3, 9 Finlin B.S.... Perou C.M. (J. Biol. Chem. 2001)
    2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    3. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Expression of CRABP1, GRP, and RERG mRNA in clinically non-functioning and functioning pituitary adenomas. (PubMed id 21270509)1 Chile T....Giorgi R.R. (J. Endocrinol. Invest. 2011)
    8. RERG (Ras-like, oestrogen-regulated, growth-inhibitor) expression in breast cancer: a marker of ER-positive luminal-like subtype. (PubMed id 20697807)1 Habashy H.O....Ellis I.O. (Breast Cancer Res. Treat. 2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85004 HGNC: 15980 AceView: RERG Ensembl:ENSG00000134533 euGenes: HUgn85004
    ECgene: RERG H-InvDB: RERG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RERG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RERG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RERG gene:
    Search GeneIP for patents involving RERG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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