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Aliases for RERG Gene

Aliases for RERG Gene

  • RAS Like Estrogen Regulated Growth Inhibitor 2 3 5
  • RAS-Like, Estrogen-Regulated, Growth Inhibitor 2

External Ids for RERG Gene

Previous GeneCards Identifiers for RERG Gene

  • GC12M015000
  • GC12M015405
  • GC12M015160

Summaries for RERG Gene

Entrez Gene Summary for RERG Gene

  • RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009]

GeneCards Summary for RERG Gene

RERG (RAS Like Estrogen Regulated Growth Inhibitor) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot for RERG Gene

  • Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RERG Gene

Genomics for RERG Gene

Regulatory Elements for RERG Gene

Enhancers for RERG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G015627 1.5 Ensembl ENCODE dbSUPER 5.2 -282.5 -282496 7.8 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 GATA2 FOS MIER2 TBX21 RERG GC12M015672 RNU6-251P LOC105369672
GH12G015156 0.7 ENCODE dbSUPER 8.5 +191.5 191519 0.8 PBX2 NR2F2 FOXA1 RERG RERG-AS1 GC12M015169
GH12G015661 1.2 Ensembl ENCODE dbSUPER 4.7 -314.1 -314088 2.0 TBP JUN CEBPB MAFG NR3C1 EP300 FOSL1 MAFF JUND ZNF316 RERG GC12M015672 RNU6-251P LOC105369672
GH12G015204 0.5 dbSUPER 9.3 +142.3 142280 3.8 CTCF TEAD4 TEAD2 GABPA TEAD3 PTPRO RERG GC12P015185 GC12P015252
GH12G015643 0.8 dbSUPER 5.1 -299.2 -299159 8.5 SOX13 TFAP4 FOXA2 SAP130 RARA GATA3 GATA2 ZNF366 SCRT2 NR2F6 RNU6-251P EPS8 RERG GC12M015672 LOC105369672
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RERG on UCSC Golden Path with GeneCards custom track

Promoters for RERG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000049210 -23 201 FUS SIN3A KLF17 ZNF2 ZNF48 ZBTB7B RAD21 ZNF366 SCRT2 ZNF143

Genomic Location for RERG Gene

Chromosome:
12
Start:
15,107,782 bp from pter
End:
15,348,675 bp from pter
Size:
240,894 bases
Orientation:
Minus strand

Genomic View for RERG Gene

Genes around RERG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RERG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RERG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RERG Gene

Proteins for RERG Gene

  • Protein details for RERG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A58-RERG_HUMAN
    Recommended name:
    Ras-related and estrogen-regulated growth inhibitor
    Protein Accession:
    Q96A58
    Secondary Accessions:
    • B2R9R0
    • B4DI02

    Protein attributes for RERG Gene

    Size:
    199 amino acids
    Molecular mass:
    22608 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RERG Gene

    Alternative splice isoforms for RERG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RERG Gene

Post-translational modifications for RERG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RERG Gene

Domains & Families for RERG Gene

Gene Families for RERG Gene

Graphical View of Domain Structure for InterPro Entry

Q96A58

UniProtKB/Swiss-Prot:

RERG_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RERG: view

Function for RERG Gene

Molecular function for RERG Gene

UniProtKB/Swiss-Prot Function:
Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.
UniProtKB/Swiss-Prot Induction:
Up-regulated by estradiol. Down-regulated by tamoxifen.

Gene Ontology (GO) - Molecular Function for RERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 11533059
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding TAS 11533059
GO:0030331 estrogen receptor binding NAS 11533059
genes like me logo Genes that share ontologies with RERG: view
genes like me logo Genes that share phenotypes with RERG: view

Animal Model Products

CRISPR Products

miRNA for RERG Gene

miRTarBase miRNAs that target RERG

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RERG Gene

Localization for RERG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RERG Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RERG gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for RERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 11533059
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 11533059
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RERG: view

Pathways & Interactions for RERG Gene

No Data Available

Gene Ontology (GO) - Biological Process for RERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA,NAS 11533059
GO:0008285 negative regulation of cell proliferation IDA 11533059
GO:0009725 response to hormone IDA 11533059
GO:0030308 negative regulation of cell growth IDA 11533059
genes like me logo Genes that share ontologies with RERG: view

No data available for Pathways by source and SIGNOR curated interactions for RERG Gene

Drugs & Compounds for RERG Gene

(2) Drugs for RERG Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for RERG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RERG: view

Transcripts for RERG Gene

Unigene Clusters for RERG Gene

RAS-like, estrogen-regulated, growth inhibitor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RERG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - -
SP7: - -

Relevant External Links for RERG Gene

GeneLoc Exon Structure for
RERG
ECgene alternative splicing isoforms for
RERG

Expression for RERG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RERG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RERG Gene

This gene is overexpressed in Uterus (x5.3) and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for RERG Gene

This gene is overexpressed in Spleen (36.0) and Ovary (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RERG Gene



NURSA nuclear receptor signaling pathways regulating expression of RERG Gene:

RERG

SOURCE GeneReport for Unigene cluster for RERG Gene:

Hs.199487

mRNA Expression by UniProt/SwissProt for RERG Gene:

Q96A58-RERG_HUMAN
Tissue specificity: Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.

Evidence on tissue expression from TISSUES for RERG Gene

  • Nervous system(4.7)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with RERG: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RERG Gene

Orthologs for RERG Gene

This gene was present in the common ancestor of animals.

Orthologs for RERG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RERG 34 35
  • 99.5 (n)
oppossum
(Monodelphis domestica)
Mammalia RERG 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RERG 34 35
  • 94.97 (n)
dog
(Canis familiaris)
Mammalia RERG 34 35
  • 93.63 (n)
rat
(Rattus norvegicus)
Mammalia Rerg 34
  • 88.61 (n)
mouse
(Mus musculus)
Mammalia Rerg 34 16 35
  • 88.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RERG 34 35
  • 81.57 (n)
lizard
(Anolis carolinensis)
Reptilia RERG 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rerg 34
  • 78.22 (n)
zebrafish
(Danio rerio)
Actinopterygii CU694368.1 35
  • 79 (a)
OneToOne
LOC101882104 34
  • 72.36 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5160 35
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToOne
Species where no ortholog for RERG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RERG Gene

ENSEMBL:
Gene Tree for RERG (if available)
TreeFam:
Gene Tree for RERG (if available)

Paralogs for RERG Gene

Variants for RERG Gene

Sequence variations from dbSNP and Humsavar for RERG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000007265 -- 15,110,867(+) CAAGA(A/C)AGACA intron-variant
rs1000040979 -- 15,156,325(+) TTTTC(C/T)CATAC intron-variant
rs1000096684 -- 15,192,628(+) ACTGA(A/T)TCAAC intron-variant
rs1000121057 -- 15,165,486(+) GTGAT(A/G)TGGGA intron-variant
rs1000143070 -- 15,149,789(+) GAAAT(A/G)GTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RERG Gene

Variant ID Type Subtype PubMed ID
esv8661 CNV gain 19470904
nsv619 CNV insertion 18451855
nsv620 CNV insertion 18451855

Variation tolerance for RERG Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RERG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RERG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RERG Gene

Disorders for RERG Gene

Relevant External Links for RERG

Genetic Association Database (GAD)
RERG
Human Genome Epidemiology (HuGE) Navigator
RERG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RERG

No disorders were found for RERG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RERG Gene

Publications for RERG Gene

  1. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. (PMID: 11533059) Finlin B.S. … Perou C.M. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  3. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 46 64
  4. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 46 64
  5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3 46 64

Products for RERG Gene

Sources for RERG Gene

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