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Aliases for RERG Gene

Aliases for RERG Gene

  • RAS-Like, Estrogen-Regulated, Growth Inhibitor 2 3

External Ids for RERG Gene

Previous GeneCards Identifiers for RERG Gene

  • GC12M015000
  • GC12M015405
  • GC12M015160

Summaries for RERG Gene

Entrez Gene Summary for RERG Gene

  • RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009]

GeneCards Summary for RERG Gene

RERG (RAS-Like, Estrogen-Regulated, Growth Inhibitor) is a Protein Coding gene. Diseases associated with RERG include pituitary carcinoma. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot for RERG Gene

  • Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RERG Gene

Genomics for RERG Gene

Regulatory Elements for RERG Gene

Genomic Location for RERG Gene

Start:
15,107,782 bp from pter
End:
15,348,675 bp from pter
Size:
240,894 bases
Orientation:
Minus strand

Genomic View for RERG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RERG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RERG Gene

Proteins for RERG Gene

  • Protein details for RERG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A58-RERG_HUMAN
    Recommended name:
    Ras-related and estrogen-regulated growth inhibitor
    Protein Accession:
    Q96A58
    Secondary Accessions:
    • B2R9R0
    • B4DI02

    Protein attributes for RERG Gene

    Size:
    199 amino acids
    Molecular mass:
    22608 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RERG Gene

    Alternative splice isoforms for RERG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RERG Gene

Proteomics data for RERG Gene at MOPED

Post-translational modifications for RERG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RERG Gene

Domains for RERG Gene

Graphical View of Domain Structure for InterPro Entry

Q96A58

UniProtKB/Swiss-Prot:

RERG_HUMAN :
  • Q96A58
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RERG: view

No data available for Gene Families for RERG Gene

Function for RERG Gene

Molecular function for RERG Gene

UniProtKB/Swiss-Prot Function: Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.
UniProtKB/Swiss-Prot Induction: Up-regulated by estradiol. Down-regulated by tamoxifen.

Gene Ontology (GO) - Molecular Function for RERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 11533059
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding TAS 11533059
GO:0030331 estrogen receptor binding NAS 11533059
genes like me logo Genes that share ontologies with RERG: view

Animal Model Products

CRISPR Products

miRNA for RERG Gene

miRTarBase miRNAs that target RERG

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RERG Gene

Localization for RERG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RERG Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RERG Gene COMPARTMENTS Subcellular localization image for RERG gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for RERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 11533059
GO:0005829 cytosol IDA 11533059
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RERG: view

Pathways for RERG Gene

SuperPathways for RERG Gene

No Data Available

Interacting Proteins for RERG Gene

Gene Ontology (GO) - Biological Process for RERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction NAS 11533059
GO:0008152 metabolic process IDA 11533059
GO:0008285 negative regulation of cell proliferation IDA 11533059
genes like me logo Genes that share ontologies with RERG: view

No data available for Pathways by source for RERG Gene

Compounds for RERG Gene

(1) HMDB Compounds for RERG Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(3) Novoseek inferred chemical compound relationships for RERG Gene

Compound -log(P) Hits PubMed IDs
gdp 69 3
gtp 58.9 6
estrogen 40.1 7
genes like me logo Genes that share compounds with RERG: view

Transcripts for RERG Gene

Unigene Clusters for RERG Gene

RAS-like, estrogen-regulated, growth inhibitor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RERG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RERG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - -
SP7: - -

Relevant External Links for RERG Gene

GeneLoc Exon Structure for
RERG
ECgene alternative splicing isoforms for
RERG

Expression for RERG Gene

mRNA expression in normal human tissues for RERG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RERG Gene

This gene is overexpressed in Uterus (5.3) and Fallopian Tube (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RERG Gene

SOURCE GeneReport for Unigene cluster for RERG Gene Hs.199487

mRNA Expression by UniProt/SwissProt for RERG Gene

Q96A58-RERG_HUMAN
Tissue specificity: Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.
genes like me logo Genes that share expressions with RERG: view

In Situ Assay Products

Orthologs for RERG Gene

This gene was present in the common ancestor of animals.

Orthologs for RERG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RERG 35
  • 99.5 (n)
  • 99.5 (a)
RERG 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RERG 35
  • 94.97 (n)
  • 99.5 (a)
RERG 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RERG 35
  • 93.63 (n)
  • 99.5 (a)
RERG 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rerg 35
  • 88.11 (n)
  • 98.49 (a)
Rerg 16
Rerg 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RERG 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rerg 35
  • 88.61 (n)
  • 97.99 (a)
chicken
(Gallus gallus)
Aves RERG 35
  • 81.57 (n)
  • 95.98 (a)
RERG 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RERG 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rerg 35
  • 78.22 (n)
  • 89.45 (a)
zebrafish
(Danio rerio)
Actinopterygii CU694368.1 36
  • 79 (a)
OneToOne
LOC101882104 35
  • 72.36 (n)
  • 80.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5160 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for RERG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RERG Gene

ENSEMBL:
Gene Tree for RERG (if available)
TreeFam:
Gene Tree for RERG (if available)

Paralogs for RERG Gene

Paralogs for RERG Gene

genes like me logo Genes that share paralogs with RERG: view

Variants for RERG Gene

Sequence variations from dbSNP and Humsavar for RERG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs715398 -- 15,157,130(-) AATGC(A/C)GAATG intron-variant
rs759529 -- 15,179,419(-) CAACA(A/G)CCTTA intron-variant
rs767201 -- 15,217,944(+) TGTAA(A/G)CATTC intron-variant
rs888164 -- 15,112,635(-) GGTCA(A/G)TCATT intron-variant
rs918098 -- 15,145,347(-) CTTCA(A/C)AGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RERG Gene

Variant ID Type Subtype PubMed ID
nsv898819 CNV Loss 21882294
nsv898820 CNV Loss 21882294
nsv619 CNV Insertion 18451855
nsv620 CNV Insertion 18451855

Relevant External Links for RERG Gene

HapMap Linkage Disequilibrium report
RERG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RERG Gene

Disorders for RERG Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RERG Gene including...

Search for RERG Gene in MalaCards »

(1) University of Copenhagen DISEASES for RERG Gene

(3) Novoseek inferred disease relationships for RERG Gene

Disease -log(P) Hits PubMed IDs
breast carcinoma 45 2
breast cancer 30.1 7
tumors 14.2 10

Relevant External Links for RERG

Genetic Association Database (GAD)
RERG
Human Genome Epidemiology (HuGE) Navigator
RERG
genes like me logo Genes that share disorders with RERG: view

No data available for UniProtKB/Swiss-Prot for RERG Gene

Publications for RERG Gene

  1. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. (PMID: 11533059) Finlin B.S. … Perou C.M. (J. Biol. Chem. 2001) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3 48
  4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 48
  5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 48

Products for RERG Gene

Sources for RERG Gene

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