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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RERG Gene

protein-coding GIFtS: 50
GCID: GC12M015160

RAS-like, estrogen-regulated, growth inhibitor

Explore 5 diseases affiliated with
RERG via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RAS-Like, Estrogen-Regulated, Growth Inhibitor¹ ²
MGC15754¹
Ras-Related And Estrogen-Regulated Growth Inhibitor²

External Ids:	HGNC: 15980¹	Entrez Gene: 85004²	Ensembl: ENSG00000134533⁷	OMIM: 612664⁵	UniProtKB: Q96A58³

Export aliases for RERG gene to outside databases

Previous GC identifers: GC12M015000 GC12M015405 GC12M015151

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RERG:

RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001

(PubMed 11533059)).(supplied by OMIM, Mar 2009)

UniProtKB/Swiss-Prot: RERG_HUMAN, Q96A58

Function: Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell

lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RERG gene promoter:
AML1a Lmo2 Nkx2-5 POU3F2 Meis-1b POU2F1 COMP1 POU2F1a Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RERG promoter sequence

Search SABiosciences Chromatin IP Primers for RERG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RERG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3 Ensembl cytogenetic band: 12p12.3 HGNC cytogenetic band: 12p13.1

RERG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RERG gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M015160: view genomic region (about GC identifiers)

Start:	15,260,716 bp from pter	End:	15,501,609 bp from pter
Size:	240,894 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RERG_HUMAN, Q96A58 (See protein sequence)

Recommended Name: Ras-related and estrogen-regulated growth inhibitor

Size: 199 amino acids; 22608 Da

Subcellular location: Cytoplasm

1 PDB 3D structure from and Proteopedia for RERG:

2ATV (3D)

Secondary accessions: B2R9R0 B4DI02

Alternative splicing: 2 isoforms: Q96A58-1 Q96A58-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RERG: NX_Q96A58

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96A58

RERG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001177655.1 NP_116307.1

ENSEMBL proteins:

ENSP00000256953 ENSP00000441505 ENSP00000438280 ENSP00000444485 ENSP00000439532

ENSP00000441860 ENSP00000440887

Human Recombinant Protein Products for RERG:

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	Novus Biologicals RERG Proteins Novus Biologicals RERG Lysates
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	ProSpec Recombinant Protein for RERG
	Uscn Proteins for RERG

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	IDA	11533059
GO:0016020	membrane	IEA	--

RERG for ontologies About GeneDecksing

RERG Antibody Products:

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	Novus Biologicals RERG Antibodies
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Assay Products for RERG:

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	Uscn ELISAs and CLIAs for RERG

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RERG for domains About GeneDecksing

3 InterPro domains/families:

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry Q96A58

ProtoNet protein and cluster: Q96A58

2 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB003577 Ras small GTPase

UniProtKB/Swiss-Prot: RERG_HUMAN, Q96A58

Similarity: Belongs to the small GTPase superfamily. Ras family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RERG_HUMAN, Q96A58

Function: Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell

lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential

Induction: Up-regulated by estradiol. Down-regulated by tamoxifen

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IDA	11533059
GO:0005525	GTP binding	IEA	--
GO:0019003	GDP binding	TAS	11533059
GO:0030331	estrogen receptor binding	NAS	11533059

RERG for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RERG

miRNA Products:		OriGene 3'-UTR Clone: RERG Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RERG
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate RERG (see all 20):
		hsa-miR-411* hsa-miR-142-5p hsa-miR-379* hsa-miR-520d-5p hsa-miR-4299 hsa-miR-340 hsa-miR-105 hsa-miR-374a*

		SwitchGear 3'UTR luciferase reporter plasmid: RERG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RERG (see all 4) OriGene shRNA RFP: RERG OriGene siRNA: RERG
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for RERG
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RERG (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RERG OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RERG (NM_024730)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RERG
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RERG

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RERG

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	--	--
GO:0007264	small GTPase mediated signal transduction	NAS	11533059
GO:0008285	negative regulation of cell proliferation	IDA	11533059
GO:0009725	response to hormone stimulus	IDA	11533059
GO:0030308	negative regulation of cell growth	IDA	11533059

RERG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RERG for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RERG

1 HMDB Compound for RERG About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

3 Novoseek chemical compound relationships for RERG gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gdp	69	7	16757349 (1), 18374156 (1), 11533059 (1)
gtp	58.9	14	16757349 (2), 18374156 (2), 11533059 (2)
estrogen	40.1	11	11533059 (3), 16757349 (2), 18374156 (2)

Search CenterWatch for drugs/clinical trials and news about RERG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RERG gene (2 alternative transcripts):

NM_001190726.1 NM_032918.2

Unigene Cluster for RERG:

RAS-like, estrogen-regulated, growth inhibitor

Hs.199487 [show with all ESTs]

Unigene Representative Sequence: NM_032918

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000256953(uc001rct.3 uc010shu.2) ENST00000538313(uc001rcs.3)

ENST00000536465 ENST00000546331 ENST00000545567 ENST00000537647 ENST00000393736

ENST00000537717 ENST00000437578

miRNA Products:		OriGene 3'-UTR Clone: RERG Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RERG
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate RERG (see all 20):
		hsa-miR-411* hsa-miR-142-5p hsa-miR-379* hsa-miR-520d-5p hsa-miR-4299 hsa-miR-340 hsa-miR-105 hsa-miR-374a*

		SwitchGear 3'UTR luciferase reporter plasmid: RERG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RERG (see all 4) OriGene shRNA RFP: RERG OriGene siRNA: RERG
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		Sirion Biotech Custom design and validation of potent shRNA sequences against RERG

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RERG (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RERG OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RERG (NM_024730)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RERG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RERG

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RERG Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RERG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RERG

Additional cDNA sequence:

AF339750.1 AK295343.1 AK311016.1 AK313881.1 BC007997.1

6 DOTS entries:

DT.444193 DT.100776638 DT.100776640 DT.100776639 DT.121141861 DT.75188081

24/113 AceView cDNA sequences (see all 113):

BX645101 CD516953 CR614972 BU632135 AA564698 D79915 AF339750 AA962466

CR599509 AA437054 BU688092 AA742672 NM_032918 AI253107 BG900183 BI758132

BX358427 BX404162 BX398732 AA037415 CR614290 BG771143 BC007997 BX335509

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RERG (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f
SP1:									-		-				-		-						-		-
SP2:									-		-				-		-						-
SP3:											-				-		-						-		-
SP4:									-		-				-		-
SP5:															-		-						-		-

ECgene alternative splicing isoforms for RERG

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RERG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTATTTTG

About this image

RERG expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Epiphyseal End

Chondrocytes

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Mesendoderm (Derivation and sorti...)

Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)

Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)

See RERG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RERG

SOURCE GeneReport for Unigene cluster: Hs.199487

UniProtKB/Swiss-Prot: RERG_HUMAN, Q96A58

Tissue specificity: Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen

receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased

or lost in a significant proportion of primary breast tumors with poor clinical prognosis

SABiosciences Custom PCR Arrays for RERG

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RERG

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RERG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RERG gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RERG¹	RAS-like, estrogen-regulated, growth inhibitor	81.57(n) 95.98(a)		418173 XM_416404.3 XP_416404.1
lizard (Anolis carolinensis)	Reptilia	RERG⁶	--	94(a)	1 ↔ 1	5(14782085-14793565)
zebrafish (Danio rerio)	Actinopterygii	zgc:110699¹	zgc:110699	52.23(n) 39.04(a)		325371 NM_001020806.1 NP_001018642.1
mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP003577¹	AGAP003577-PA	45.96(n) 37.88(a)		1274241 XM_313330.4 XP_313330.4

ENSEMBL Gene Tree for RERG (if available)
TreeFam Gene Tree for RERG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RERG gene

RASL12² RASL11A² RERGL² RASL11B²

18/55 SIMAP similar genes for RERG using alignment to 4 protein entries: RERG_HUMAN (see all proteins) (see all similar genes):

K-RAS KRAS c-bas/has RRAS2 RIT2 RAP1B

RALB RALA RAP2A DKFZp547A0616 RAP2B RIT1

MRAS RAP2C RAP1A RERGL HRAS NRAS

RERG for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76329696^1,2	F	--	15260371(+)	`CGAGGT/ACTGGA`	2	--	ds500¹		1		WA	118
rs10492168^1,2	C,F,H	--	15260563(-)	`TTTAGG/ATGCTA`	2	--	ds500¹		88		NS EA PA EU CA WA NA	4590
rs7306800^1,2	C,F,A,H	--	15260636(+)	`TGTCAA/GTTTTG`	2	--	ds500¹		21		NS EA NA WA	2548
rs139605226^1,2		--	15260677(+)	`AAATTA/GTAAAT`	2	--	ds500¹		0	--	--	--	--
rs143421080^1,2		--	15260714(+)	`CCCAAA/GTATGA`	2	--	ds500¹		0	--	--	--	--
rs151194954^1,2		--	15260782(+)	`AAGTTA/GTCCAA`	2	--	ut3¹		0	--	--	--	--
rs182940730^1,2		--	15260809(+)	`ATGCCA/GCTAAC`	2	--	ut3¹		0	--	--	--	--
rs145698865^1,2	C	--	15260984(+)	`ATACA-/AGAGAGT`	2	--	ut3¹		0	--	--	--	--
rs1045733^1,2	C,F,O,H	--	15260993(-)	`CTAAAA/GCAGAC`	2	--	ut3¹		18		MN NA NS EA WA	1514
rs2098409^1,2	C,H	--	15261117(-)	`AATTAG/TCCTCT`	2	--	ut3¹ ese³		9		MN NS EA	792

HapMap Linkage Disequilibrium report for RERG (15260716 - 15501609 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RERG
1 Indel: 60080

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RERG

DNA2.0 Custom Variant and Variant Library Synthesis for RERG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RERG for disorders           About GeneDecksing

OMIM gene information: 612664    OMIM disorders: --

5 diseases for RERG:    About MalaCards

pituitary carcinoma breast cancer pulmonary disease hepatocellular carcinoma

carcinoma

3 Novoseek disease relationships for RERG gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast carcinoma	45	4	16757349 (1), 11533059 (1)
breast cancer	30.1	11	18374156 (5), 17043425 (1), 11533059 (1)
tumors	14.2	11	16757349 (4), 11533059 (3), 17043425 (2), 18374156 (1)

Human Genome Epidemiology (HuGE) Navigator: RERG (4 documents)

Export disorders for RERG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RERG gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with RERG)

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RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. (PubMed id 11533059)^{1, 2, 3, 9} Finlin B.S.... Perou C.M. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Expression of CRABP1, GRP, and RERG mRNA in clinically non-functioning and functioning pituitary adenomas. (PubMed id 21270509)¹ Chile T....Giorgi R.R. (2011)
RERG (Ras-like, oestrogen-regulated, growth-inhibitor ) expression in breast cancer: a marker of ER-positive luminal-like subtype. (PubMed id 20697807)¹ Habashy H.O....Ellis I.O. (2011)
Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)¹ Guey L.T....Malats N. (2010)
PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)¹ Hosgood H.D....Lan Q. (2009)
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)¹ Shen M....Lan Q. (2009)
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)¹ Hosgood H.D....Lan Q. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 85004	HGNC: 15980	AceView: RERG	Ensembl:ENSG00000134533	euGenes: HUgn85004
ECgene: RERG	H-InvDB: RERG

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RERG	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RERG	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RERG gene
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Patent Information for RERG gene:
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RAS-like, estrogen-regulated, growth inhibitor

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RAS-like, estrogen-regulated, growth inhibitor

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