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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RERE Gene

protein-coding   GIFtS: 56
GCID: GC01M008412

arginine-glutamic acid dipeptide (RE) repeats


(Previous symbol: ATN1L)
 Explore 12 diseases affiliated with
RERE via our new
 Human Malady Compendium 
Biological research products
for RERE
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Arginine-Glutamic Acid Dipeptide (RE) Repeats1 2     Atrophin-1-Like Protein2 3
ARG1 2 3     Atrophin-1-Related Protein2 3
ARP1 2 3     Arginine-Glutamic Acid Dipeptide Repeats Protein2
ATN1L1 2 3     Atrophin 22
DNB11 2     Atrophin-1 Like Protein2
KIAA04581 3     Atrophin-1 Related Protein2

External Ids:    HGNC: 99651   Entrez Gene: 4732   Ensembl: ENSG000001425997   OMIM: 6052265   UniProtKB: Q9P2R63   

Export aliases for RERE gene to outside databases

Previous GC identifers: GC01M007994 GC01M008221 GC01M008122 GC01M008346 GC01M007562


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RERE:
This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins.
The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers
apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a
transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RERE_HUMAN, Q9P2R6
Function: Plays a role as a transcriptional repressor during development. May play a role in the control of cell
survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation,
leading to cell death

Gene Wiki entry for RERE


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RERE gene promoter:
         STAT1   Pbx1a   FOXD3   AP-4   Evi-1   AREB6   CP2   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RERE promoter sequence
   Search SABiosciences Chromatin IP Primers for RERE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RERE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.23

RERE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RERE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M008412:  view genomic region     (about GC identifiers)

Start:
8,412,457 bp from pter      End:
8,877,702 bp from pter
Size:
465,246 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RERE_HUMAN, Q9P2R6 (See protein sequence)
Recommended Name: Arginine-glutamic acid dipeptide repeats protein  
Size: 1566 amino acids; 172424 Da
Subunit: Interacts with HDAC1 (By similarity). Interacts with ATN1. Interaction with ATN1 is improved when the poly-Gln
region of ATN1 is extended. Interacts with FAT1
Subcellular location: Nucleus. Note=Localized in nuclear bodies of variables size. Colocalized with PML and BAX in
nuclear PODs
Sequence caution: Sequence=AAC31120.1; Type=Frameshift; Positions=588, 596; Sequence=AAD27584.1; Type=Erroneous
initiation;
1 PDB 3D structure from and Proteopedia for RERE:
2YQK (3D)    
Secondary accessions: O43393 O75046 O75359 Q5VXL9 Q6P6B9 Q9Y2W4
Alternative splicing: 2 isoforms:  Q9P2R6-1   Q9P2R6-2   

Explore the universe of human proteins at neXtProt for RERE: NX_Q9P2R6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2R6

  • RERE Protein expression data from MOPED and PaxDb:    About this image 
    RERE Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001036146.1  NP_001036147.1  NP_036234.3  

    ENSEMBL proteins: 
     ENSP00000338629   ENSP00000366684   ENSP00000383699   ENSP00000422246   ENSP00000383700  
     ENSP00000423451   ENSP00000465133   ENSP00000464847   ENSP00000464712   ENSP00000423259  
     ENSP00000465271  

    Human Recombinant Protein Products for RERE: 
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    Novus Biologicals RERE Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RERE

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex IEA--
    GO:0005634nucleus NAS10814707
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--

    RERE for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RERE


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RERE for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR001025 BAH_dom
     IPR000679 Znf_GATA
     IPR002951 Atrophin-like

    Graphical View of Domain Structure for InterPro Entry Q9P2R6

    ProtoNet protein and cluster: Q9P2R6

    3 Blocks protein families:
    IPB000679 Zn-finger
    IPB001005 Myb DNA-binding domain
    IPB001025 Bromo adjacent region


    UniProtKB/Swiss-Prot: RERE_HUMAN, Q9P2R6
    Domain: The interaction with ATN1 is mediated by the coiled coil domain
    Similarity: Contains 1 BAH domain
    Similarity: Contains 1 ELM2 domain
    Similarity: Contains 1 GATA-type zinc finger
    Similarity: Contains 1 SANT domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RERE_HUMAN, Q9P2R6
    Function: Plays a role as a transcriptional repressor during development. May play a role in the control of cell
    survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation,
    leading to cell death

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI16713569
    GO:0008267poly-glutamine tract binding TAS10814707
         
    RERE for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rere):
     cardiovascular system  craniofacial  embryogenesis  mortality/aging  nervous system 
     normal  vision/eye 

    RERE for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RERE 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RERE:
    hsa-mir-429 (MIRT002988), hsa-mir-200b (MIRT002987)

    OriGene 3'-UTR Clone (see all 3): RERE
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RERE
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate RERE (see all 92):
    hsa-miR-411* hsa-miR-607 hsa-miR-3152-3p hsa-miR-128 hsa-miR-632 hsa-miR-1244 hsa-miR-629* hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidRERE 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RERE (see all 7)
    OriGene shRNA RFP: RERE
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of RERE 
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): RERE (NM_001042682)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RERE 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RERE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RERE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/77 Interacting proteins for RERE (Q9P2R61, 2, 3 ENSP000003386294) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFEMP2O959672, 3, ENSP000003099534MINT-2872661 MINT-2872680 I2D: score=2 STRING: ENSP00000309953
    ECM1Q166102, 3, ENSP000003580434MINT-2858291 I2D: score=3 STRING: ENSP00000358043
    PRRC2AP486342, 3, ENSP000003651754MINT-2864518 I2D: score=3 STRING: ENSP00000365175
    ALG13Q9NP732, 3, ENSP000003610474MINT-2876453 I2D: score=2 STRING: ENSP00000361047
    EFEMP1Q128052, 3, ENSP000003475964MINT-2858932 I2D: score=2 STRING: ENSP00000347596
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006338chromatin remodeling IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006607NLS-bearing substrate import into nucleus TAS10814707
    GO:0007275multicellular organismal development IEA--

    RERE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RERE for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RERE
    1 Novoseek chemical compound relationship for RERE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 29.2 5 10814707 (4)

    Search CenterWatch for drugs/clinical trials and news about RERE 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RERE gene (3 alternative transcripts): 
    NM_001042681.1  NM_001042682.1  NM_012102.3  

    Unigene Cluster for RERE:

    Arginine-glutamic acid dipeptide (RE) repeats
    Hs.463041  [show with all ESTs]
    Unigene Representative Sequence: NM_012102
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337907(uc001apd.3 uc001ape.3 uc001apf.3) ENST00000377464(uc010nzx.1)
    ENST00000467350 ENST00000400907 ENST00000476556 ENST00000400908 ENST00000505225
    ENST00000464367 ENST00000488215 ENST00000460659 ENST00000492766 ENST00000465125
    ENST00000464972 ENST00000480342(uc001aph.1) ENST00000507012 ENST00000469251
    ENST00000514428 ENST00000468247

    miRNA
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    OriGene 3'-UTR Clone (see all 3): RERE
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RERE
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate RERE (see all 92):
    hsa-miR-411* hsa-miR-607 hsa-miR-3152-3p hsa-miR-128 hsa-miR-632 hsa-miR-1244 hsa-miR-629* hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidRERE 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RERE (see all 7)
    OriGene shRNA RFP: RERE
    OriGene siRNA: RERE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RERE
    Sirion Biotech Custom design and validation of potent shRNA sequences against RERE 
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RERE (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RERE (see all 3)
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    GenScript: all cDNA clones in your preferred vector (see all 3): RERE (NM_001042682)
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    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RERE
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RERE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RERE

    Additional cDNA sequence: 

    AB007927.2 AB036737.1 AF016005.1 AF118275.1 AK074834.1 AK096094.1 AL050176.1 BC009619.1 
    BC062342.1 

    23 DOTS entries:

    DT.100791085  DT.95250589  DT.92448690  DT.100791090  DT.100015497  DT.95340827  DT.440511  DT.100791081 
    DT.80100512  DT.91660374  DT.92448689  DT.100791089  DT.95340843  DT.97859695  DT.121454272  DT.75119822 
    DT.86853056  DT.92448681  DT.92448695  DT.95340826  DT.97766075  DT.100037227  DT.121454238 

    24/450 AceView cDNA sequences (see all 450):

    AW501189 AA810897 AI799598 AA323480 AA595637 AA133434 BQ023408 AI633448 
    AW007347 BM696179 BU169617 CR618919 AA603174 CD300775 CF264794 BU168687 
    AA328952 AI287885 AA724500 AA427720 BF034285 AA282600 BE350628 BF940452 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RERE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGATAACACA
    RERE Expression
    About this image
    See RERE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RERE

    SOURCE GeneReport for Unigene cluster: Hs.463041

    UniProtKB/Swiss-Prot: RERE_HUMAN, Q9P2R6
    Tissue specificity: Widely expressed. Expressed in tumor cell lines

        SABiosciences Custom PCR Arrays for RERE
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RERE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RERE gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RERE1 arginine-glutamic acid dipeptide (RE) repeats 80.34(n)
    90.55(a)
      419435  XM_417594.3  XP_417594.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia BG816159.12   -- 80.65(n)    BG816159.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM071136.12   -- 82.25(n)    BM071136.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gug3 leg morphogenesis (sensu Holometabola)
    transcription more
    62(a)   3 66D1   --
    worm
    (Caenorhabditis elegans)
    Secernentea egl-273 Expression: all somatic cells, embryo, L1
    larva, more
    32(a)   II(6834345-6836829)   --


    ENSEMBL Gene Tree for RERE (if available)
    TreeFam Gene Tree for RERE (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RERE gene
    MTA32  MTA22  MTA12  ATN12  
    3 SIMAP similar genes for RERE using alignment to 8 protein entries:     RERE_HUMAN (see all proteins):
    MTA1    tmp_locus_6    ATN1

    RERE for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RERE
    PGOHUM00000246988 PGOHUM00000233884 PGOHUM00000234037


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7142 NCBI SNPs in RERE are shown (see all 7142    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1159869981,2
    C,Fother8418710(+) GGGTCG/AACGTT 6 /V syn12Minor allele frequency- A:0.02WA NA 3896
    rs1450509351,2
    --8412020(+) GCTGGA/GTGGCT 3 -- ds50010--------
    rs740496121,2
    C--8412063(+) GGGGAG/AGCAGA 3 -- ds50012Minor allele frequency- A:0.10WA 120
    rs1848973471,2
    --8412089(+) AGGCCA/GCTAGG 3 -- ds50010--------
    rs1907363551,2
    --8412141(+) ACATGC/TCCATA 3 -- ds50010--------
    rs1816679241,2
    --8412220(+) TCCCAA/GTGCCA 3 -- ds50010--------
    rs1995364391,2
    --8412324(+) TCTGG-/AAGC  
            
    CACTC
    3 -- ds50010--------
    rs1868443101,2
    --8412363(+) GCAGGC/GAACAG 3 -- ds50010--------
    rs771563641,2
    F--8412396(+) CCCACC/GTGGGG 3 -- ds50011Minor allele frequency- G:0.03NA 120
    rs412789701,2
    --8412556(+) TTTCTC/GGGTGT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for RERE (8412457 - 8662457 bp, first 250kb of RERE)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 27 variations for RERE
         15/22 CNVs (see all 22): 84037 71728 74325 5465 74327 84038 84036 66605 0003 84042 71729 84040 84041 66387 74324
         5 Indels: 74322 44644 84035 74323 74321

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RERE for disorders           About GeneDecksing

    OMIM gene information: 605226    OMIM disorders: --

    UniProtKB/Swiss-Prot: RERE_HUMAN, Q9P2R6
  • Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line NGP. Translocation
  • t(1;15)(p36.2;q24)

    12 diseases for RERE:    About MalaCards
    dentatorubral-pallidoluysian atrophy    esophageal squamous cell carcinoma    squamous cell carcinoma    retinal degeneration
    mediastinitis    vitiligo    esophagitis    retinitis
    ataxia    carcinoma    neuroblastoma    leukemia

    1 disease from the University of Copenhagen DISEASES database for RERE:
    dentatorubral-pallidoluysian atrophy

    1 Novoseek disease relationship for RERE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    drpla 84.4 23 10814707 (5), 19006237 (1)

    Human Genome Epidemiology (HuGE) Navigator: RERE (3 documents)

    Export disorders for RERE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RERE gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with RERE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine. (PubMed id 10814707)1, 2, 3, 9 Yanagisawa H.... Yamada M. (2000)
    2. Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP. (PubMed id 10729226)1, 2, 3 Amler L.C....Hampton G.M. (2000)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis. (PubMed id 11331249)1, 2 Waerner T.... Kraut N. (2001)
    5. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (1997)
    6. Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis. (PubMed id 14645126)1, 9 Zoltewicz J.S....Peterson A.S. (2004)
    7. Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates. (PubMed id 18451879)1, 9 Wang L....Tsai C.C. (2008)
    8. Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells. (PubMed id 19131340)2, 9 Hou R. and Sibinga N.E. (2009)
    9. Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors. (PubMed id 16481466)1, 9 Wang L....Tsai C.C. (2006)
    10. Genome-wide association study identifies five new schi zophrenia loci. (PubMed id 21926974)1 (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 473 HGNC: 9965 AceView: RERE Ensembl:ENSG00000142599 euGenes: HUgn473
    ECgene: RERE H-InvDB: RERE

    (According to HUGE)
    About This Section
    HUGE: KIAA0458

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RERE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RERE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RERE gene:
    Search GeneIP for patents involving RERE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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