RER1 Gene
protein-coding GIFtS: 47
GCID: GC01P002313
|
|
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)
| |
Aliases
for RER1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RER1 Retention In Endoplasmic Reticulum 1 Homolog (S. Cerevisiae)1 2 | | Protein RER12 |
Export aliases for RER1 gene to outside databasesPrevious GC identifers: GC01P001878 GC01P002336 GC01P001983 GC01P002192 GC01P002355 GC01P001601 |
Summaries
for RER1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RER1:
The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It isinvolved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membraneproteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. (provided by RefSeq, Oct2009)
UniProtKB/Swiss-Prot: RER1_HUMAN, O15258Function: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment (Bysimilarity)
|
Genomic Views
for RER1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RER1 gene promoter:
NF-1 ISGF-3 RFX1 p53 Pax-5 AP-4 LUN-1 STAT3 c-Myb ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for RER1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RER1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.32 HGNC cytogenetic band: 1p36RER1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P002313: view genomic region
(about GC identifiers)
Start:
|
2,323,214 bp from pter |
End:
|
2,336,883 bp from pter |
Size:
|
13,670 bases |
Orientation:
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plus strand |
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Proteins
for RER1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RER1_HUMAN, O15258 (See
protein sequence)Recommended Name: Protein RER1 Size: 196 amino acids; 22958 Da
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein
Secondary accessions: O95322Explore the universe of human proteins at neXtProt for RER1: NX_O15258
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15258
RER1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_008964.3
ENSEMBL proteins: ENSP00000367779 ENSP00000302088 ENSP00000367773 ENSP00000417000 ENSP00000464222 ENSP00000367774
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RER1 for ontologies About GeneDecksing
RER1 Antibody Products:
Assay Products for RER1: |
Protein
Domains /
Families
for RER1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RER1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O15258ProtoNet protein and cluster: O15258 1 Blocks protein family: IPB004932 Retrieval of early ER protein Rer1
UniProtKB/Swiss-Prot: RER1_HUMAN, O15258Similarity: Belongs to the RER1 family |
Function
for RER1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RER1_HUMAN, O15258Function: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RER1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RER1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: RER1 (NM_007033) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RER1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
RER1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RER1:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rer1):
RER1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RER1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RER1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/76 Interacting proteins for RER1 (O152583 ENSP000003020884) via UniProtKB, MINT, STRING, and/or I2D (see all 76)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER |
IDA | 9309388 |
RER1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RER1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RER1
Search CenterWatch for drugs/clinical trials and news about RER1
|
Transcripts
for RER1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RER1 gene: NM_007033.4 Unigene Cluster for RER1: RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae) Hs.741204 [show with all ESTs]Unigene Representative Sequence: NM_0070338 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378518 ENST00000306256(uc001aje.2) ENST00000493207 ENST00000378512(uc001ajf.2)
ENST00000443438 ENST00000488353 ENST00000462129 ENST00000378513
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RER1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RER1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RER1 (NM_007033) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RER1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RER1 |
Additional cDNA sequence: AF091071.1 AF157324.1 AJ001421.1 AK095750.1 AK289658.1 BC004965.1 BC025684.1 BT007224.1 CR456806.1 24/33 DOTS entries (see all 33): DT.92451230 DT.40192381 DT.121455823 DT.121455878 DT.449647 DT.100031041 DT.100829687 DT.100829672 DT.100775762 DT.100829676 DT.121455895 DT.100829682 DT.95170667 DT.121455710 DT.121455798 DT.92451237 DT.95170675 DT.92451224 DT.121455860 DT.95170672 DT.97799701 DT.121455760 DT.121455886 DT.220001 24/564 AceView cDNA sequences (see all 564): AW051415 AI419368 BU185288 BU619358 BU849564 AJ001421 BQ183530 AI362297 AA931241 AA694219 CA487826 AI337907 AI146605 BC004965 AW406557 BP339056 AI306393 AI421221 AA725437 BQ891678 BU160421 AA505139 BP338734 BE792846
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RER1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RER1
|
Expression
for RER1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RER1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RER1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RER1
SOURCE GeneReport for Unigene cluster: Hs.741204
SABiosciences Custom PCR Arrays for RER1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RER1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RER1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RER1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RER1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RER1 |
Orthologs
for RER1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RER1 gene from 9/36 species (see all 36) About this table
ENSEMBL Gene Tree for RER1 (if available)
TreeFam Gene Tree for RER1 (if available) |
Paralogs
for RER1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RER1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RER1 (2323214 - 2336883 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for RER1
5 CNVs: 53347 29815 4193 29817 29816
1 Indel: 97257 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RER1 |
|
Disorders
/ Diseases
for RER1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RER1 for disorders About GeneDecksing
1  disease for RER1: About MalaCardsmalaria
Export disorders for RER1 gene to outside databases
|
Publications
for RER1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RER1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with RER1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human Rer1 is localized to the Golgi apparatus and complements the deletion of the homologous Rer1 protein of Saccharomyces cerevisiae. (PubMed id 9309388)1, 2, 3, 9 Fuellekrug J....Schmitt H. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for RER1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RER1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RER1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RER1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RER1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RER1 gene:
Search GeneIP for patents involving RER1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RER1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RER1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RER1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RER1 | | | OriGene Protein Over-expression Lysate for RER1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RER1 | | OriGene 3'-UTR Clone for RER1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RER1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RER1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RER1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RER1 | | OriGene Custom Protein Services for RER1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RER1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RER1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RER1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RER1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RER1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RER1 |
| |
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| |  |  |  |  | | | | |
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 | | | RER1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RER1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RER1 |
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