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Aliases for RER1 Gene

Aliases for RER1 Gene

  • Retention In Endoplasmic Reticulum Sorting Receptor 1 2 3
  • RER1 Retention In Endoplasmic Reticulum 1 Homolog (S. Cerevisiae) 2

External Ids for RER1 Gene

Previous GeneCards Identifiers for RER1 Gene

  • GC01P001878
  • GC01P002336
  • GC01P001983
  • GC01P002192
  • GC01P002355
  • GC01P002313
  • GC01P001601

Summaries for RER1 Gene

Entrez Gene Summary for RER1 Gene

  • The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. [provided by RefSeq, Oct 2009]

GeneCards Summary for RER1 Gene

RER1 (Retention In Endoplasmic Reticulum Sorting Receptor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RER1 Gene

  • Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RER1 Gene

Genomics for RER1 Gene

Regulatory Elements for RER1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RER1 Gene

Start:
2,391,775 bp from pter
End:
2,405,444 bp from pter
Size:
13,670 bases
Orientation:
Plus strand

Genomic View for RER1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RER1 Gene

Proteins for RER1 Gene

  • Protein details for RER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15258-RER1_HUMAN
    Recommended name:
    Protein RER1
    Protein Accession:
    O15258
    Secondary Accessions:
    • O95322

    Protein attributes for RER1 Gene

    Size:
    196 amino acids
    Molecular mass:
    22958 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RER1 Gene

Proteomics data for RER1 Gene at MOPED

Post-translational modifications for RER1 Gene

  • Ubiquitination at Lys14
  • Modification sites at PhosphoSitePlus

Other Protein References for RER1 Gene

No data available for DME Specific Peptides for RER1 Gene

Domains for RER1 Gene

Protein Domains for RER1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15258

UniProtKB/Swiss-Prot:

RER1_HUMAN :
  • O15258
Family:
  • Belongs to the RER1 family.
genes like me logo Genes that share domains with RER1: view

No data available for Gene Families for RER1 Gene

Function for RER1 Gene

Molecular function for RER1 Gene

UniProtKB/Swiss-Prot Function: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.

Gene Ontology (GO) - Molecular Function for RER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0033130 acetylcholine receptor binding IEA --
genes like me logo Genes that share ontologies with RER1: view

Phenotypes for RER1 Gene

MGI mutant phenotypes for RER1:
inferred from 1 alleles
GenomeRNAi human phenotypes for RER1:
genes like me logo Genes that share phenotypes with RER1: view

Animal Model Products

CRISPR Products

miRNA for RER1 Gene

miRTarBase miRNAs that target RER1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RER1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RER1 Gene

Localization for RER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RER1 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RER1 Gene COMPARTMENTS Subcellular localization image for RER1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
endoplasmic reticulum 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0005794 Golgi apparatus IDA --
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane --
GO:0030173 integral component of Golgi membrane IDA 9309388
genes like me logo Genes that share ontologies with RER1: view

Pathways for RER1 Gene

SuperPathways for RER1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IDA 9309388
GO:0007528 neuromuscular junction development --
GO:0071340 skeletal muscle acetylcholine-gated channel clustering IEA --
GO:0090004 positive regulation of establishment of protein localization to plasma membrane IEA --
genes like me logo Genes that share ontologies with RER1: view

No data available for Pathways by source for RER1 Gene

Transcripts for RER1 Gene

Unigene Clusters for RER1 Gene

RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RER1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RER1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - -
SP8:
SP9: - - - - - -
SP10: - -

Relevant External Links for RER1 Gene

GeneLoc Exon Structure for
RER1
ECgene alternative splicing isoforms for
RER1

Expression for RER1 Gene

mRNA expression in normal human tissues for RER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RER1 Gene

SOURCE GeneReport for Unigene cluster for RER1 Gene Hs.525527

genes like me logo Genes that share expressions with RER1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RER1 Gene

Orthologs for RER1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RER1 35
  • 99.32 (n)
  • 99.49 (a)
RER1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RER1 35
  • 86.9 (n)
  • 96.94 (a)
RER1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RER1 35
  • 88.1 (n)
  • 96.43 (a)
RER1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rer1 35
  • 88.27 (n)
  • 96.43 (a)
Rer1 16
Rer1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RER1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RER1 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rer1 35
  • 88.1 (n)
  • 96.43 (a)
chicken
(Gallus gallus)
Aves RER1 35
  • 81.8 (n)
  • 94.39 (a)
RER1 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rer1 35
  • 77.04 (n)
  • 91.33 (a)
Str.10143 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
rer1 35
  • 73.98 (n)
  • 84.18 (a)
rer1 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011996 35
  • 64.02 (n)
  • 69.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11857 35
  • 62.01 (n)
  • 65.92 (a)
CG11857 36
  • 49 (a)
OneToOne
CG11857 37
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea rer-1 35
  • 60.78 (n)
  • 59.89 (a)
rer-1 36
  • 60 (a)
OneToOne
F46C5.8 37
  • 56 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL002W 35
  • 53.49 (n)
  • 47.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RER1 35
  • 53.5 (n)
  • 50.96 (a)
RER1 36
  • 43 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08624g 35
  • 57.52 (n)
  • 51.83 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7172 35
thale cress
(Arabidopsis thaliana)
eudicotyledons ATRER1A 35
  • 58.99 (n)
  • 58.18 (a)
rice
(Oryza sativa)
Liliopsida Os01g0106200 35
  • 57.32 (n)
  • 55.03 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06447 35
  • 63.25 (n)
  • 61.45 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rer1 35
  • 55.91 (n)
  • 53.16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4669 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1642 36
  • 64 (a)
OneToOne
Species with no ortholog for RER1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RER1 Gene

ENSEMBL:
Gene Tree for RER1 (if available)
TreeFam:
Gene Tree for RER1 (if available)

Paralogs for RER1 Gene

No data available for Paralogs for RER1 Gene

Variants for RER1 Gene

Sequence variations from dbSNP and Humsavar for RER1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13888 -- 2,399,484(+) CTCCC(A/C)AAGTG reference, missense
rs14648 -- 2,399,475(+) CTTTT(C/T)TTTCT reference, missense
rs903911 -- 2,395,373(+) AGACA(A/G)GGTGC intron-variant
rs1123571 -- 2,394,570(+) TATCT(A/G)TAAAT intron-variant, upstream-variant-2KB
rs1129333 -- 2,404,237(-) ACTGG(C/T)ACAAG utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RER1 Gene

Variant ID Type Subtype PubMed ID
nsv834668 CNV Loss 17160897
dgv64n71 CNV Loss 21882294
nsv871930 CNV Loss 21882294
nsv870616 CNV Gain 21882294
dgv69n71 CNV Loss 21882294
dgv70n71 CNV Loss 21882294
dgv71n71 CNV Loss 21882294
dgv72n71 CNV Loss 21882294
dgv73n71 CNV Loss 21882294
nsv870492 CNV Loss 21882294
dgv74n71 CNV Loss 21882294
dgv75n71 CNV Loss 21882294
nsv823697 CNV Gain 20364138
nsv470684 CNV Loss 18288195
nsv870567 CNV Loss 21882294
dgv76n71 CNV Loss 21882294
esv2631918 CNV Insertion 19546169
dgv1n27 CNV Loss 19166990
nsv512710 CNV Insertion 21212237
nsv823808 CNV Gain 20364138
dgv77n71 CNV Gain 21882294

Relevant External Links for RER1 Gene

HapMap Linkage Disequilibrium report
RER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RER1 Gene

Disorders for RER1 Gene

No disorders were found for RER1 Gene.

No data available for UniProtKB/Swiss-Prot for RER1 Gene

Publications for RER1 Gene

  1. Human Rer1 is localized to the Golgi apparatus and complements the deletion of the homologous Rer1 protein of Saccharomyces cerevisiae. (PMID: 9309388) Fuellekrug J. … Schmitt H. (Eur. J. Cell Biol. 1997) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1. (PMID: 17668005) Kaether C. … Haass C. (EMBO Rep. 2007) 2 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for RER1 Gene

Sources for RER1 Gene

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