Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RER1 Gene

protein-coding   GIFtS: 50
GCID: GC01P002313

Retention In Endoplasmic Reticulum Sorting Receptor 1

(Previous name: RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Retention In Endoplasmic Reticulum Sorting Receptor 11 2
RER1 Retention In Endoplasmic Reticulum 1 Homolog (S. Cerevisiae)1
Protein RER12
RER1 Retention In Endoplasmic Reticulum 1 Homolog2

External Ids:    HGNC: 303091   Entrez Gene: 110792   Ensembl: ENSG000001579167   UniProtKB: O152583   

Export aliases for RER1 gene to outside databases

Previous GC identifers: GC01P001878 GC01P002336 GC01P001983 GC01P002192 GC01P002355 GC01P001601


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RER1 Gene:
The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is
involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane
proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. (provided by RefSeq,
Oct 2009)

GeneCards Summary for RER1 Gene:
RER1 (retention in endoplasmic reticulum sorting receptor 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: RER1_HUMAN, O15258
Function: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RER1 gene promoter:
         NF-1   ISGF-3   RFX1   p53   Pax-5   AP-4   LUN-1   STAT3   c-Myb   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRER1 promoter sequence
   Search Chromatin IP Primers for RER1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RER1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36

RER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RER1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P002313:  view genomic region     (about GC identifiers)

Start:
2,323,214 bp from pter      End:
2,336,883 bp from pter
Size:
13,670 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RER1_HUMAN, O15258 (See protein sequence)
Recommended Name: Protein RER1  
Size: 196 amino acids; 22958 Da
Secondary accessions: O95322

Explore the universe of human proteins at neXtProt for RER1: NX_O15258

Explore proteomics data for RER1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys14
  • Modification sites at PhosphoSitePlus

  • See RER1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008964.3  
    ENSEMBL proteins: 
     ENSP00000367779   ENSP00000475168   ENSP00000302088   ENSP00000367773   ENSP00000417000  
     ENSP00000464222   ENSP00000367774  

    RER1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RER1
    OriGene Protein Over-expression Lysate for RER1
    OriGene MassSpec for RER1
    OriGene Custom Protein Services for RER1
    GenScript Custom Purified and Recombinant Proteins Services for RER1
    Novus Biologicals RER1 Protein
    Novus Biologicals RER1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RER1

     
    Search eBioscience for Proteins for RER1 

     
    antibodies-online proteins for RER1 (2 products) 

     
    antibodies-online peptides for RER1

    RER1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RER1
    OriGene Custom Antibody Services for RER1
    Novus Biologicals RER1 Antibody
    Abcam antibodies for RER1
    Cloud-Clone Corp. Antibodies for RER1
    Search ThermoFisher Antibodies for RER1
    antibodies-online antibodies for RER1 (8 products) 

    RER1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RER1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RER1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RER1
    Cloud-Clone Corp. CLIAs for RER1
    Search eBioscience for ELISAs for RER1 
    antibodies-online kits for RER1 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR004932 Rer1

    Graphical View of Domain Structure for InterPro Entry O15258

    ProtoNet protein and cluster: O15258

    1 Blocks protein domain: IPB004932 Retrieval of early ER protein Rer1

    UniProtKB/Swiss-Prot: RER1_HUMAN, O15258
    Similarity: Belongs to the RER1 family


    Find genes that share domains with RER1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RER1_HUMAN, O15258
    Function: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment
    (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with RER1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RER1:
     Decreased cell number 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rer1):
     muscle  nervous system 

    Find genes that share phenotypes with RER1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RER1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RER1:
    hsa-mir-324-5p (MIRT043203), hsa-mir-484 (MIRT041841), hsa-mir-548b-3p (MIRT016241)

    Block miRNA regulation of human, mouse, rat RER1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RER1 (see all 38):
    hsa-miR-2052 hsa-miR-374a hsa-miR-3653 hsa-miR-371-5p hsa-miR-3658 hsa-miR-3613-3p hsa-miR-374b hsa-miR-627
    SwitchGear 3'UTR luciferase reporter plasmidRER1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RER1
    Predesigned siRNA for gene silencing in human, mouse, rat RER1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RER1

    Clone
    Products:
         
    OriGene clones in human, mouse for RER1 (see all 6)
    OriGene ORF clones in mouse, rat for RER1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RER1 (NM_007033)
    Sino Biological Human cDNA Clone for RER1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RER1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RER1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RER1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RER1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RER1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RER1_HUMAN, O15258: Golgi apparatus membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane3
    endoplasmic reticulum2
    lysosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IDA--
    GO:0016021integral component of membrane ----
    GO:0030173integral component of Golgi membrane IDA9309388

    Find genes that share ontologies with RER1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RER1
    Interactions:

        Search GeneGlobe Interaction Network for RER1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RER1 (O152583 ENSP000003020884) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206286Q8N1B43I2D: score=1 
    ENSG00000224455Q8N1B43I2D: score=1 
    ENSG00000225590Q8N1B43I2D: score=1 
    ENSG00000228425Q8N1B43I2D: score=1 
    ENSG00000236014Q8N1B43I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER IDA9309388

    Find genes that share ontologies with RER1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RER1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RER1 gene: 
    NM_007033.4  

    Unigene Cluster for RER1:

    RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)
    Hs.525527  [show with all ESTs]
    Unigene Representative Sequence: NM_007033
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378518 ENST00000605895 ENST00000306256(uc001aje.2) ENST00000493207
    ENST00000378512(uc001ajf.2) ENST00000443438 ENST00000488353 ENST00000462129
    ENST00000378513
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RER1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RER1 (see all 38):
    hsa-miR-2052 hsa-miR-374a hsa-miR-3653 hsa-miR-371-5p hsa-miR-3658 hsa-miR-3613-3p hsa-miR-374b hsa-miR-627
    SwitchGear 3'UTR luciferase reporter plasmidRER1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RER1
    Predesigned siRNA for gene silencing in human, mouse, rat RER1
    Clone
    Products:
         
    OriGene clones in human, mouse for RER1 (see all 6)
    OriGene ORF clones in mouse, rat for RER1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RER1 (NM_007033)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RER1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RER1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RER1
    OriGene qSTAR qPCR primer pairs in human, mouse for RER1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RER1
      QuantiTect SYBR Green Assays in human, mouse, rat RER1
      QuantiFast Probe-based Assays in human, mouse, rat RER1

    Additional mRNA sequence: 

    AF091071.1 AF157324.1 AJ001421.1 AK095750.1 AK289658.1 BC004965.1 BC025684.1 BT007224.1 
    CR456806.1 

    Selected DOTS entries (see all 34):

    DT.92451230  DT.40192381  DT.121455823  DT.121455878  DT.449647  DT.100031041  DT.100829687  DT.100829672 
    DT.100775762  DT.100829676  DT.121455895  DT.100829682  DT.95170667  DT.121455710  DT.121455798  DT.92451237 
    DT.95170675  DT.92451224  DT.95312444  DT.121455860  DT.95170672  DT.97799701  DT.121455760  DT.121455886 

    Selected AceView cDNA sequences (see all 564):

    AA824520 AI192145 BG740446 BQ668605 BQ923882 CA848709 BQ230856 BQ687789 
    AW051415 AI298394 AA666334 BE792846 BQ183530 AA424086 BM790330 BQ722672 
    AV709812 BQ944837 BU160421 AI146656 AI568520 BM695619 Z40830 AW470962 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RER1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d
    SP1:                                -     -     -     -     -     -                 -                       -     -                                       
    SP2:                                -     -     -     -     -                       -                       -     -                                       
    SP3:                                -     -     -     -     -     -                 -                       -                                             
    SP4:                                -     -     -     -     -     -                 -           -           -     -                                       
    SP5:                                                  -     -     -                 -                       -     -                                       


    ECgene alternative splicing isoforms for RER1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RER1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RER1 Expression
    About this image


    RER1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    RER1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RER1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525527
        Custom PCR Arrays for RER1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RER1
    OriGene qSTAR qPCR primer pairs in human, mouse for RER1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RER1
    QuantiTect SYBR Green Assays in human, mouse, rat RER1
    QuantiFast Probe-based Assays in human, mouse, rat RER1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RER1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RER1 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rer11 , 5 RER1 retention in endoplasmic reticulum 1 homolog (S. more1, 5 88.27(n)1
    96.43(a)1
      4 (86.17 cM)5
    678301  NM_026395.11  NP_080671.11 
     1550741105 
    chicken
    (Gallus gallus)
    Aves RER11 RER1 retention in endoplasmic reticulum 1 homolog (S. more 81.8(n)
    94.39(a)
      419397  NM_001006300.1  NP_001006300.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BI446701.12   -- 81.86(n)    BI446701.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY398406.12   -- 79.61(n)   393648  AY398406.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG118571 , 3 vesicle-mediated transport3
    CG118571
    63(a)3
    62.01(n)1
    65.92(a)1
      96C83
    430421  NM_143105.31  NP_651362.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F46C5.83
    rer-11
    endoplasmic reticular protein3
    rer-11
    56(a)3
    60.78(n)1
    59.89(a)1
      II(8811292-8812178)3
    1744101  NM_063477.61  NP_495878.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RER11 RER1 53.5(n)
    50.96(a)
      850354   NP_009925.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATRER1A1 ATRER1A 58.99(n)
    58.18(a)
      830077  NM_120082.3  NP_195633.1 
    rice
    (Oryza sativa)
    Liliopsida CA762697.12   -- 71.57(n)    CA762697.1 


    ENSEMBL Gene Tree for RER1 (if available)
    TreeFam Gene Tree for RER1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RER1 (see all 445)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1489692391,2
    --1604391(+) CAGCGC/TATCAG 1 -- int10--------
    rs1487507491,2
    C--1611294(+) CTCCT-/CCTCCTC 1 -- int10--------
    rs726421891,2
    C--1611540(+) CTCCTC/TCTCCC 1 -- int10--------
    rs788205981,2
    C--1611553(+) CTCCTC/TCCTCC 1 -- int10--------
    rs1839403101,2
    --2300761(+) CAACCA/TCCCGG 1 -- us2k10--------
    rs2020996441,2
    --2300802(+) GCAGCA/TGCAAG 1 -- us2k10--------
    rs2003950001,2
    --2300842(+) TCCTCC/TCTGCT 1 -- us2k10--------
    rs1998035951,2
    --2300880(+) GAATTG/TGGGTA 1 -- us2k10--------
    rs347131781,2
    C--2300889(-) GTCTAC/TGTATA 1 -- us2k11Minor allele frequency- T:0.01NA 74
    rs2002389821,2
    C--2300911(+) AGTATT/CGAGAA 1 -- us2k11Minor allele frequency- C:0.00EU 1323

    HapMap Linkage Disequilibrium report for RER1 (2323214 - 2336883 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RER1 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2631918CNV Insertion19546169
    nsv512710CNV Insertion21212237
    dgv70n71CNV Loss21882294
    nsv834668CNV Loss17160897
    nsv870567CNV Loss21882294
    dgv73n71CNV Loss21882294
    dgv72n71CNV Loss21882294
    dgv74n71CNV Loss21882294
    dgv71n71CNV Loss21882294
    nsv870492CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RER1
    DNA2.0 Custom Variant and Variant Library Synthesis for RER1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RER1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with RER1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Rer1 is localized to the Golgi apparatus and complements the deletion of the homologous Rer1 protein of Saccharomyces cerevisiae. (PubMed id 9309388)1, 2, 3, 9 Fuellekrug J....Schmitt H. (Eur. J. Cell Biol. 1997)
    2. Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1. (PubMed id 17668005)1, 3 Kaether C....Haass C. (EMBO Rep. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Rer1p maintains ciliary length and signaling by regulating I^-secretase activity and Foxj1a levels. (PubMed id 23479743)1 Jurisch-Yaksi N....Annaert W. (J. Cell Biol. 2013)
    7. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. (PubMed id 23246001)1 Xu Y....Ye Y. (Cell Rep 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    10. Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-I^ (AI^) production by altering trafficking of I^-secretase and amyloid precursor protein (APP). (PubMed id 23043097)1 Park H.J....Kim S.H. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 11079 HGNC: 30309 AceView: RER1 Ensembl:ENSG00000157916 euGenes: HUgn11079
    ECgene: RER1 H-InvDB: RER1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RER1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RER1 gene:
    Search GeneIP for patents involving RER1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RER1   OriGene RNAi products in human, mouse, rat for RER1  
     OriGene qPCR primer pairs and template standards for RER1   OriGene Protein Over-expression Lysate for RER1  
     OriGene MassSpec for RER1   OriGene clones in human, mouse for RER1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RER1   OriGene Purified Protein for RER1  
     OriGene ORF clones in mouse, rat for RER1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RER1   OriGene Custom Protein Services for RER1  

     
     
     Block miRNA regulation of human, mouse, rat RER1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RER1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RER1 Predesigned siRNA for gene silencing in human, mouse, rat RER1
     QuantiFast Probe-based Assays in human, mouse, rat RER1 QuantiTect SYBR Green Assays in human, mouse, rat RER1
     Custom PCR Arrays for RER1 Search Chromatin IP Primers for RER1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RER1  Search GeneGlobe Interaction Network for RER1
     Regulatory tfbs in RER1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RER1 GenScript cDNA clones with any tag delivered in your preferred vector for RER1
     GenScript Custom Assay Services for RER1 GenScript Custom overexpressing Cell Line Services for RER1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RER1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for RER1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RER1 antibodies
     RER1 proteins
     RER1 lysates
     Antibodies for RER1
     See all of Abcam's Antibodies, Kits and Proteins for RER1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RER1
     Antibodies for RER1
     ELISAs for RER1
     CLIAs for RER1



     Browse ESI BIO Cell Lines and PureStem Progenitors for RER1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RER1
     SwitchGear 3'UTR luciferase reporter plasmids for RER1
     SwitchGear Promoter luciferase reporter plasmids for RER1
     Search ThermoFisher Antibodies for RER1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RER1
     Browse compounds at ApexBio
     Search Addgene for plasmids for RER1
      Search eBioscience for proteins for RER1
      Search eBioscience for elisas for RER1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for RER1
     antibodies-online antibodies for RER1 (8 products)
     antibodies-online kits for RER1 (10 products)
     antibodies-online peptides for RER1
     antibodies-online proteins for RER1 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RER1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4