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Aliases for REPS2 Gene

Aliases for REPS2 Gene

  • RALBP1 Associated Eps Domain Containing 2 2 3
  • Partner Of RalBP1 3 4
  • POB1 3 4
  • Partner Of Ral-Binding Protein 1 3
  • RALBP1-Interacting Protein 2 3
  • RalBP1-Interacting Protein 2 4

External Ids for REPS2 Gene

Previous GeneCards Identifiers for REPS2 Gene

  • GC0XM016700
  • GC0XP015813
  • GC0XP016166
  • GC0XP016326
  • GC0XP016724
  • GC0XP014724

Summaries for REPS2 Gene

Entrez Gene Summary for REPS2 Gene

  • The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for REPS2 Gene

REPS2 (RALBP1 Associated Eps Domain Containing 2) is a Protein Coding gene. Diseases associated with REPS2 include prostate cancer. Among its related pathways are Cytoskeleton remodeling_RalA regulation pathway and EGFR1 Signaling Pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is EHD1.

UniProtKB/Swiss-Prot for REPS2 Gene

  • Involved in growth factor signaling through its influence on the Ral signaling pathway

Gene Wiki entry for REPS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REPS2 Gene

Genomics for REPS2 Gene

Regulatory Elements for REPS2 Gene

Genomic Location for REPS2 Gene

16,946,691 bp from pter
17,220,732 bp from pter
274,042 bases
Plus strand

Genomic View for REPS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REPS2 Gene

Proteins for REPS2 Gene

  • Protein details for REPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RalBP1-associated Eps domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A6PWZ6
    • O43428
    • Q5JNZ8
    • Q8NFI5

    Protein attributes for REPS2 Gene

    660 amino acids
    Molecular mass:
    71534 Da
    Quaternary structure:
    • Interacts with ASAP1 and this complex can bind paxillin. May form a ternary complex with RALBP1 and ASAP1 (By similarity). Interacts with RALBP1 and GRB2. Binding to RALBP1 does not affect the Ral-binding activity of the latter. It can form a ternary complex with activated Ral and RALBP1. Binds EPN1.

    Three dimensional structures from OCA and Proteopedia for REPS2 Gene

    Alternative splice isoforms for REPS2 Gene


neXtProt entry for REPS2 Gene

Proteomics data for REPS2 Gene at MOPED

Post-translational modifications for REPS2 Gene

  • EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter protein such as GRB2
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REPS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for REPS2 Gene

Domains & Families for REPS2 Gene

Gene Families for REPS2 Gene

Protein Domains for REPS2 Gene

Suggested Antigen Peptide Sequences for REPS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EF-hand domain.
  • Contains 1 EF-hand domain.
  • Contains 2 EH domains.
genes like me logo Genes that share domains with REPS2: view

Function for REPS2 Gene

Molecular function for REPS2 Gene

UniProtKB/Swiss-Prot Function:
Involved in growth factor signaling through its influence on the Ral signaling pathway

Gene Ontology (GO) - Molecular Function for REPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 9422736
genes like me logo Genes that share ontologies with REPS2: view

Phenotypes for REPS2 Gene

genes like me logo Genes that share phenotypes with REPS2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REPS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for REPS2 Gene

Localization for REPS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REPS2 Gene


Gene Ontology (GO) - Cellular Components for REPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with REPS2: view

No data available for Subcellular locations from COMPARTMENTS for REPS2 Gene

Pathways & Interactions for REPS2 Gene

genes like me logo Genes that share pathways with REPS2: view

Pathways by source for REPS2 Gene

1 BioSystems pathway for REPS2 Gene

Gene Ontology (GO) - Biological Process for REPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 9422736
GO:0007173 epidermal growth factor receptor signaling pathway TAS 9422736
genes like me logo Genes that share ontologies with REPS2: view

No data available for SIGNOR curated interactions for REPS2 Gene

Drugs & Compounds for REPS2 Gene

No Compound Related Data Available

Transcripts for REPS2 Gene

Unigene Clusters for REPS2 Gene

RALBP1 associated Eps domain containing 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REPS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REPS2 Gene

No ASD Table

Relevant External Links for REPS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REPS2 Gene

mRNA expression in normal human tissues for REPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for REPS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.4), Pancreas (10.8), Liver (9.3), and Frontal cortex (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for REPS2 Gene

SOURCE GeneReport for Unigene cluster for REPS2 Gene Hs.186810

mRNA Expression by UniProt/SwissProt for REPS2 Gene

Tissue specificity: Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. Isoform 2 is down-regulated during progression of prostate cancer
genes like me logo Genes that share expression patterns with REPS2: view

Protein tissue co-expression partners for REPS2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for REPS2 Gene

Orthologs for REPS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for REPS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia REPS2 35
  • 88.94 (n)
  • 90.61 (a)
REPS2 36
  • 89 (a)
(Canis familiaris)
Mammalia REPS2 35
  • 89.89 (n)
  • 91.63 (a)
REPS2 36
  • 92 (a)
(Mus musculus)
Mammalia Reps2 35
  • 88.29 (n)
  • 89.24 (a)
Reps2 16
Reps2 36
  • 89 (a)
(Pan troglodytes)
Mammalia REPS2 35
  • 99.68 (n)
  • 100 (a)
REPS2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Reps2 35
  • 86.62 (n)
  • 86.65 (a)
(Monodelphis domestica)
Mammalia REPS2 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia REPS2 36
  • 69 (a)
(Gallus gallus)
Aves REPS2 35
  • 69.71 (n)
  • 68.68 (a)
REPS2 36
  • 67 (a)
(Anolis carolinensis)
Reptilia REPS2 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia reps2 35
  • 62.39 (n)
  • 57.4 (a)
Str.9777 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15149 35
(Danio rerio)
Actinopterygii LOC101882936 35
  • 57.05 (n)
  • 53.24 (a)
REPS2 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Reps 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for REPS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for REPS2 Gene

Gene Tree for REPS2 (if available)
Gene Tree for REPS2 (if available)

Paralogs for REPS2 Gene

Paralogs for REPS2 Gene

genes like me logo Genes that share paralogs with REPS2: view

Variants for REPS2 Gene

Sequence variations from dbSNP and Humsavar for REPS2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs11864 -- 17,153,177(+) TGAAA(A/G)GTCTG utr-variant-3-prime, intron-variant
rs713355 -- 17,062,369(-) ATCAG(C/T)TTTTC intron-variant
rs714070 -- 17,103,979(-) ATTGA(A/G)GAAAC intron-variant
rs751177 -- 17,129,556(-) ACCAC(C/T)GCATG intron-variant
rs751178 -- 17,129,543(-) GTTAT(A/G)TCAGG intron-variant

Variation tolerance for REPS2 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REPS2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for REPS2 Gene

Disorders for REPS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for REPS2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association
Search REPS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for REPS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with REPS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REPS2 Gene

Publications for REPS2 Gene

  1. Mass spectroscopic phosphoprotein mapping of Ral binding protein 1 (RalBP1/Rip1/RLIP76). (PMID: 17706599) Herlevsen M.C. … Theodorescu D. (Biochem. Biophys. Res. Commun. 2007) 23 67
  2. EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2. (PMID: 15455380) Oosterhoff J.K. … Blok L.J. (Int. J. Cancer 2005) 23 67
  3. POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis. (PMID: 15707977) Yadav S. … Awasthi S. (Biochem. Biophys. Res. Commun. 2005) 23 67
  4. Novel factors in regulation of activin signaling. (PMID: 15451561) Tsuchida K. … Sugino H. (Mol. Cell. Endocrinol. 2004) 23 67
  5. Identification of REPS2 as a putative modulator of NF-kappaB activity in prostate cancer cells. (PMID: 15184881) Penninkhof F. … Blok L.J. (Oncogene 2004) 23 67

Products for REPS2 Gene

Sources for REPS2 Gene

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