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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REPS2 Gene

protein-coding   GIFtS: 54
GCID: GC0XP016874

RALBP1 associated Eps domain containing 2
 Explore 4 diseases affiliated with
REPS2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for REPS2    

Aliases
for REPS2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RALBP1 Associated Eps Domain Containing 21 2
POB11 2 3 5
Partner Of RalBP12 3
RalBP1-Interacting Protein 22 3
Partner Of Ral-Binding Protein 12
RalBP1-Associated Eps Domain-Containing Protein 22

External Ids:    HGNC: 99631   Entrez Gene: 91852   Ensembl: ENSG000001698917   OMIM: 3003175   UniProtKB: Q8NFH83   

Export aliases for REPS2 gene to outside databases

Previous GC identifers: GC0XM016700 GC0XP015813 GC0XP016166 GC0XP016326 GC0XP016724 GC0XP014724


Summaries
for REPS2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for REPS2:
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The
encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein
Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: REPS2_HUMAN, Q8NFH8
Function: Involved in growth factor signaling through its influence on the Ral signaling pathway

Gene Wiki entry for REPS2


Genomic Views
for REPS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REPS2 gene promoter:
         Nkx3-1   Nkx3-1 v4   AML1a   Egr-1   Nkx3-1 v1   AREB6   Nkx3-1 v2   FOXO1a   Nkx3-1 v3   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: REPS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for REPS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REPS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.2

REPS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REPS2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP016874:  view genomic region     (about GC identifiers)

Start:
 16,964,814 bp from pter      End:
 17,171,403 bp from pter
Size:
 206,590 bases      Orientation:
 plus strand

Proteins
for REPS2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: REPS2_HUMAN, Q8NFH8 (See protein sequence)
Recommended Name: RalBP1-associated Eps domain-containing protein 2  
Size: 660 amino acids; 71534 Da
Subunit: Interacts with ASAP1 and this complex can bind paxillin. May form a ternary complex with RALBP1 and ASAP1 (By
similarity). Interacts with RALBP1 and GRB2. Binding to RALBP1 does not affect the Ral-binding activity of the latter.
It can form a ternary complex with activated Ral and RALBP1. Binds EPN1
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for REPS2:
1IQ3 (3D)    
Secondary accessions: A6PWZ6 O43428 Q5JNZ8 Q8NFI5
Alternative splicing: 4 isoforms:  Q8NFH8-1   Q8NFH8-2   Q8NFH8-3   Q8NFH8-4   

Explore the universe of human proteins at neXtProt for REPS2: NX_Q8NFH8

Post-translational modifications:

  • EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter
    • protein such as GRB21
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NFH8

    • REPS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001074444.1  NP_004717.2  

    ENSEMBL proteins: 
     ENSP00000349824   ENSP00000306033   ENSP00000369404  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): REPS2
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    Novus Biologicals REPS2 Protein
    Novus Biologicals REPS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for REPS2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--


    REPS2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for REPS2

    Protein Domains /
    Families
    for REPS2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    REPS2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR026814 Reps
     IPR000261 EPS15_homology
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q8NFH8

    ProtoNet protein and cluster: Q8NFH8

    1 Blocks protein family: IPB000261 EPS15 homology (EH)

    UniProtKB/Swiss-Prot: REPS2_HUMAN, Q8NFH8
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 2 EH domains


    Function
    for REPS2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: REPS2_HUMAN, Q8NFH8
    Function: Involved in growth factor signaling through its influence on the Ral signaling pathway

    miRNA
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    8/137 QIAGEN miScript miRNA Assays for microRNAs that regulate REPS2 (see all 137):
    hsa-miR-124* hsa-miR-579 hsa-miR-100* hsa-miR-199a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-149
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    Inhib. RNA
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    OriGene shRNA RFP: REPS2
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REPS2 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for REPS2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REPS2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI9422736


    REPS2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for REPS2:
     Increased cilium length after  


    Pathways & Interactions
    for REPS2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeleton remodeling_RalB regulation pathway
    		Cytoskeleton remodeling_RalB regulation pathway1.00
    		Cytoskeleton remodeling_RalA regulation pathway0.23
    		Cytoskeleton remodeling RalB regulation pathway1.00
    		Cytoskeleton remodeling RalA regulation pathway0.23
    2EGFR1 Signaling Pathway
    		EGFR1 Signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for REPS2
        Cytoskeleton remodeling RalB regulation pathway
    Cytoskeleton remodeling RalA regulation pathway


    2 GeneGo (Thomson Reuters) Pathways for REPS2
        Cytoskeleton remodeling RalB regulation pathway
    Cytoskeleton remodeling RalA regulation pathway

    1 BioSystems Pathway for REPS2 
        EGFR1 Signaling Pathway



    REPS2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for REPS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/24 Interacting proteins for REPS2 (Q8NFH82, 3 ENSP000003498244) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629932, 3, ENSP000003390074MINT-7027552 MINT-7027478 MINT-7027533 MINT-7027633 MINT-7027690 MINT-7027593 MINT-7027493 MINT-7027672 I2D: score=1 STRING: ENSP00000339007
    EPN1Q9Y6I32, 3, ENSP000004062094MINT-19262 MINT-51395 I2D: score=2 STRING: ENSP00000406209
    BIN1O004992, ENSP000003167794MINT-7027462 MINT-7027569 MINT-7027512 MINT-7027708 MINT-7027613 MINT-7027653 STRING: ENSP00000316779
    TRAPPC2LQ9UL332, 3, ENSP000003010214MINT-8201570 I2D: score=1 STRING: ENSP00000301021
    YWHAZP631042, ENSP000003095034MINT-7032317 MINT-7032426 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS9422736
    GO:0006898receptor-mediated endocytosis IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS9422736


    REPS2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for REPS2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REPS2
    Search CenterWatch for drugs/clinical trials and news about REPS2 

    Transcripts
    for REPS2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for REPS2 gene (2 alternative transcripts): 
    NM_001080975.1  NM_004726.2  

    Unigene Cluster for REPS2:

    RALBP1 associated Eps domain containing 2
    Hs.186810  [show with all ESTs]
    Unigene Representative Sequence: NM_004726
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357277(uc004cxv.1 uc004cxw.1) ENST00000303843(uc011miw.1)
    ENST00000481792 ENST00000469714 ENST00000470686 ENST00000380064

    miRNA
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    8/137 QIAGEN miScript miRNA Assays for microRNAs that regulate REPS2 (see all 137):
    hsa-miR-124* hsa-miR-579 hsa-miR-100* hsa-miR-199a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REPS2 (see all 4)
    OriGene shRNA RFP: REPS2
    OriGene siRNA: REPS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REPS2
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): REPS2 (NM_001080975)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REPS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REPS2

    Additional cDNA sequence: 

    AB208937.1 AF010233.1 AF511533.1 AF512951.1 AK097484.1 AK298913.1 

    8 DOTS entries:

    DT.313542  DT.112413  DT.95280566  DT.97838267  DT.99979111  DT.121292379  DT.203412  DT.92033672 

    24/48 AceView cDNA sequences (see all 48):

    CK820947 BM789376 CB529363 BM725284 AA771947 AI346893 AI281353 BM677725 
    NM_004726 AF010233 AF511533 AF512951 AW297955 N89827 CA447647 CB529874 
    CK820948 BM709908 BX099975 AL706678 BM745138 AA191588 AK057127 BM770902 

    GeneLoc Exon Structure


    Expression
    for REPS2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REPS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGTGAAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    REPS2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See REPS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REPS2

    SOURCE GeneReport for Unigene cluster: Hs.186810

    UniProtKB/Swiss-Prot: REPS2_HUMAN, Q8NFH8
    Tissue specificity: Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in
    the kidney. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell
    lines and xenografts. Isoform 2 is down-regulated during progression of prostate cancer

        SABiosciences Custom PCR Arrays for REPS2
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REPS2

    Orthologs
    for REPS2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for REPS2 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves REPS21 RALBP1 associated Eps domain containing 2 69.72(n)
    68.45(a)    		   418617  NM_001030806.1  NP_001025977.1 
    lizard
    (Anolis carolinensis)    		 Reptilia REPS26
    		 --
    		 66(a)
    		 1 ↔ 1
    		 3(122189751-122255290)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.151492 Xenopus laevis transcribed sequence with weak similarity more 73.07(n)    BJ067014.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01021396.16
    		 --
    		 45(a)
    		 1 ↔ 1
    		 23(41182967-41279331)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Reps6
    		 --
    		 12(a)
    		 1 → many
    		 2L(11100963-11106652)
    worm
    (Caenorhabditis elegans)    		 Secernentea reps-16
    		 REPS (RalBP1-associated Eps domain-containing prot...
    		 13(a)
    		 1 → many
    		 V(18986430-18990380)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G207606
    AT1G216306
    		 calcium-binding EF-hand-containing protein
    		 8(a)
    7(a)
    		 many ↔ many
    many ↔ many
    		 1(7209369-7214993)
    1(7581084-7588151)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 EF hand family protein, putative, expressed
    		 8(a)
    7(a)
    		 many ↔ many
    many ↔ many
    		 6(31012733-31020756)
    3(1719030-1726903)


    ENSEMBL Gene Tree for REPS2 (if available)
    TreeFam Gene Tree for REPS2 (if available) 

    Paralogs
    for REPS2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for REPS2 gene
    REPS12  

    REPS2 for paralogs           About GeneDecksing



    Genomic Variants
    for REPS2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2082 NCBI SNPs in REPS2 are shown (see all 2082)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1857137851,2
    		--16963149(+) TTTTCC/TAGTGG 2 -- us2k10--------
    rs1890228451,2
    		--16963314(+) CTGCAA/GGCACT 2 -- us2k10--------
    rs1817507001,2
    		--16963500(+) TAGAGA/GGCCAG 2 -- us2k10--------
    rs1856159771,2
    		--16963705(+) GGCAGA/GATAAT 2 -- us2k10--------
    rs1903778901,2
    		--16963722(+) AACCCA/GGGAGG 2 -- us2k10--------
    rs70633971,2
    		C,F,H,--16963831(+) TAGAGT/GACTAG 2 -- us2k14Minor allele frequency- G:0.07NS 790
    rs1389424761,2
    		--16963944(+) GGTTTC/TGCATT 2 -- us2k10--------
    rs590437991,2
    		C,--16963979(+) GTTTTG/CTACTA 2 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1814450941,2
    		--16964064(+) ATTTTC/TAGGCC 2 -- us2k10--------
    rs1463901991,2
    		--16964100(+) AGATAG/TTCAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for REPS2 (16964814 - 17171403 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for REPS2: --
    Human Gene Mutation Database (HGMD): REPS2

    Locus Specific Mutation Databases (LSDB): REPS2

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    Disorders / Diseases
    for REPS2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    REPS2 for disorders           About GeneDecksing

    OMIM gene information: 300317    OMIM disorders: --

    4 diseases for REPS2:    About MalaCards
    prostate cancer    prostate cancer, progression of    prostatitis    breast cancer

    1 Novoseek disease relationship for REPS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 36 9 15184881 (4), 15455380 (3), 15707977 (1)


    Export disorders for REPS2 gene to outside databases

    Publications
    for REPS2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REPS2 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with REPS2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1). (PubMed id 9928989)1, 2, 3 Koshiba S....Yokoyama S. (1999)
    2. Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral. (PubMed id 9422736)1, 2, 3 Ikeda M.... Kikuchi A. (1998)
    3. REPS2/POB1 is downregulated during human prostate cancer progression and inhibits growth factor signalling in prostate cancer cells. (PubMed id 12771942)1, 2 Oosterhoff J.K....Blok L.J. (2003)
    4. Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis. (PubMed id 10557078)1, 2 Morinaka K....Kikuchi A. (1999)
    5. Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration. (PubMed id 12149250)1, 9 Oshiro T....Kikuchi A. (2002)
    6. POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis. (PubMed id 15707977)1, 9 Yadav S....Awasthi S. (2005)
    7. Identification of REPS2 as a putative modulator of NF-kappaB activity in prostate cancer cells. (PubMed id 15184881)1, 9 Penninkhof F....Blok L.J. (2004)
    8. EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2. (PubMed id 15455380)1, 9 Oosterhoff J.K....Blok L.J. (2005)
    9. Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. (PubMed id 10393179)1, 9 Nakashima S....Kikuchi A. (1999)
    10. TMEM25, REPS2 and Meis 1: favourable prognostic and p redictive biomarkers for breast cancer. (PubMed id 19776672)1 Doolan P....O'Driscoll L. (2009)

    External Searches for REPS2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing REPS2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9185 HGNC: 9963 AceView: REPS2 Ensembl:ENSG00000169891 euGenes: HUgn9185
    ECgene: REPS2 H-InvDB: REPS2

    Other Databases showing REPS2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing REPS2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REPS2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for REPS2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for REPS2 gene:
    Search GeneIP for patents involving REPS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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