Aliases for REPS1 Gene
External Ids for REPS1 Gene
Previous GeneCards Identifiers for REPS1 Gene
This gene encodes a signaling adaptor protein with two EH domains that interacts with proteins that participate in signaling, endocytosis and cytoskeletal changes. The encoded protein has been found in association with intersectin 1 and Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1 when intersectin 1 was isolated from clathrin-coated pits. The encoded protein has also been shown to interact with amphiphysin, a cytoplasmic protein at the surface of synaptic vesicles. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
GeneCards Summary for REPS1 Gene
REPS1 (RALBP1 Associated Eps Domain Containing 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include calcium ion binding and SH3 domain binding. An important paralog of this gene is ITSN1.
UniProtKB/Swiss-Prot for REPS1 Gene
May coordinate the cellular actions of activated EGF receptors and Ral-GTPases.