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REPS1 Gene

protein-coding   GIFtS: 53
GCID: GC06M139267

RALBP1 Associated Eps Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RALBP1 Associated Eps Domain Containing 11 2
RalBP1-Interacting Protein 12 3
RALBP12
RalBP1-Associated Eps Domain-Containing Protein 12

External Ids:    HGNC: 155781   Entrez Gene: 850212   Ensembl: ENSG000001355977   OMIM: 6148255   UniProtKB: Q96D713   

Export aliases for REPS1 gene to outside databases

Previous GC identifers: GC06M138848 GC06M139073 GC06M139206 GC06M136787


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for REPS1 Gene:
This gene encodes a signaling adaptor protein with two EH domains that interacts with proteins that participate in
signaling, endocytosis and cytoskeletal changes. The encoded protein has been found in association with
intersectin 1 and Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1
when intersectin 1 was isolated from clathrin-coated pits. The encoded protein has also been shown to interact
with amphiphysin, a cytoplasmic protein at the surface of synaptic vesicles. Alternative splicing results in
multiple transcript variants encoding different isoforms. (provided by RefSeq, Mar 2014)

GeneCards Summary for REPS1 Gene:
REPS1 (RALBP1 associated Eps domain containing 1) is a protein-coding gene. GO annotations related to this gene include SH3 domain binding and calcium ion binding. An important paralog of this gene is EPS15L1.

UniProtKB/Swiss-Prot: REPS1_HUMAN, Q96D71
Function: May coordinate the cellular actions of activated EGF receptors and Ral-GTPases (By similarity)

Gene Wiki entry for REPS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the REPS1 gene promoter:
         Pbx1a   AP-2alpha isoform 3   FOXO3   AP-2alpha isoform 2   C/EBPalpha   FOXO4   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): REPS1 promoter sequence
   Search Chromatin IP Primers for REPS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REPS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.1   Ensembl cytogenetic band:  6q24.1   HGNC cytogenetic band: 6q24.1

REPS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REPS1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M139267:  view genomic region     (about GC identifiers)

Start:
139,224,630 bp from pter      End:
139,309,398 bp from pter
Size:
84,769 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: REPS1_HUMAN, Q96D71 (See protein sequence)
Recommended Name: RalBP1-associated Eps domain-containing protein 1  
Size: 796 amino acids; 86662 Da
Subunit: Homodimer (Potential). Interacts with RAB11FIP2. Interacts with RALBP1, CRK and GRB2. Binding to RALBP1
does not affect its Ral-binding activity. Forms a complex with the SH3 domains of CRK and GRB2 which may link it
to an EGF-responsive tyrosine kinase (By similarity). Interacts with AMPH, ITSN1 (via SH3 domains) and SGIP1; may
be involved in clathrin-mediated endocytosis
Sequence caution: Sequence=AAH12764.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH21211.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAK34942.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B7ZBZ8 B7ZBZ9 B7ZC00 Q5JWJ5 Q5JWJ6 Q5JWJ7 Q8NDR7 Q8WU62 Q9BXY9
Alternative splicing: 3 isoforms:  Q96D71-1   Q96D71-2   Q96D71-3   

Explore the universe of human proteins at neXtProt for REPS1: NX_Q96D71

Explore proteomics data for REPS1 at MOPED

Post-translational modifications: 

  • EGF stimulates phosphorylation on Tyr-residues (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See REPS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001122089.1  NP_001273540.1  NP_001273541.1  NP_114128.3  

    ENSEMBL proteins: 
     ENSP00000392065   ENSP00000356635   ENSP00000434251   ENSP00000401729   ENSP00000432157  
     ENSP00000435392   ENSP00000386699   ENSP00000258062   ENSP00000397941   ENSP00000435236  
     ENSP00000435131   ENSP00000402609   ENSP00000403740   ENSP00000431474  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    5 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR026814 Reps
     IPR000261 EPS15_homology
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q96D71

    ProtoNet protein and cluster: Q96D71

    1 Blocks protein domain: IPB000261 EPS15 homology (EH)

    UniProtKB/Swiss-Prot: REPS1_HUMAN, Q96D71
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 2 EH domains


    Find genes that share domains with REPS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REPS1_HUMAN, Q96D71
    Function: May coordinate the cellular actions of activated EGF receptors and Ral-GTPases (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
    GO:0017124SH3 domain binding IPI--
         
    Find genes that share ontologies with REPS1           About GenesLikeMe


    Animal Models:
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    Block miRNA regulation of human, mouse, rat REPS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate REPS1 (see all 14):
    hsa-miR-3163 hsa-miR-495 hsa-miR-409-3p hsa-miR-513a-5p hsa-miR-27a hsa-miR-3065-5p hsa-miR-128 hsa-miR-3681*
    SwitchGear 3'UTR luciferase reporter plasmidREPS1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    REPS1_HUMAN, Q96D71: Membrane, clathrin-coated pit. Note=Colocalize with ITSN1 at the plasma membrane in
    structures that are most probably clathrin-coated pits
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0005905coated pit IDA--

    Find genes that share ontologies with REPS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for REPS1 About    
    See pathways by source

    SuperPathContained pathways About
    1EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway
    2Cytoskeleton remodeling RalB regulation pathway
    Cytoskeleton remodeling RalB regulation pathway
    3Cytoskeleton remodeling RalA regulation pathway
    Cytoskeleton remodeling RalA regulation pathway
    4Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with REPS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for REPS1
        FGF Pathway
    Molecular Mechanisms of Cancer
    Ras Pathway

    1 Cell Signaling Technology (CST) Pathway for REPS1
        Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for REPS1
        Cytoskeleton remodeling RalB regulation pathway
    Cytoskeleton remodeling RalA regulation pathway

    1 BioSystems Pathway for REPS1
        EGFR1 Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for REPS1
    Interactions:

        GeneGlobe Interaction Network for REPS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for REPS1 (Q96D712, 3 ENSP000002580624) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STON2Q8WXE92, 3, ENSP000002675404MINT-6180180 I2D: score=1 STRING: ENSP00000267540
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    RALBP112343, ENSP000002725194I2D: score=1 STRING: ENSP00000272519
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    RALAP112333, ENSP000000052574I2D: score=1 STRING: ENSP00000005257
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis ----

    Find genes that share ontologies with REPS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for REPS1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for REPS1 gene (4 alternative transcripts): 
    NM_001128617.2  NM_001286611.1  NM_001286612.1  NM_031922.4  

    Unigene Cluster for REPS1:

    RALBP1 associated Eps domain containing 1
    Hs.334603  [show with all ESTs]
    Unigene Representative Sequence: NM_031922
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000450536(uc003qig.4 uc011edr.2 uc003qii.3 uc003qij.3 uc003qik.3)
    ENST00000367663 ENST00000529597 ENST00000445570 ENST00000478483 ENST00000483468
    ENST00000484164 ENST00000409812 ENST00000258062 ENST00000415951 ENST00000526022
    ENST00000526244 ENST00000492787 ENST00000530370 ENST00000529423 ENST00000530255
    ENST00000431346 ENST00000414243
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    hsa-miR-3163 hsa-miR-495 hsa-miR-409-3p hsa-miR-513a-5p hsa-miR-27a hsa-miR-3065-5p hsa-miR-128 hsa-miR-3681*
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      QuantiFast Probe-based Assays in human, mouse, rat REPS1

    Additional mRNA sequence: 

    AF251052.1 AJ420514.1 AK024197.1 AK312938.1 AL049259.1 AL831900.1 AL832307.1 BC012764.2 
    BC021211.2 BC035286.1 

    17 DOTS entries:

    DT.100817834  DT.100803897  DT.452607  DT.100817833  DT.102819990  DT.95376041  DT.40195577  DT.438627 
    DT.121386629  DT.91754438  DT.92063003  DT.95204334  DT.91757382  DT.97793778  DT.100817836  DT.204817 
    DT.97785237 

    Selected AceView cDNA sequences (see all 196):

    AL831900 BE816114 AA486978 AI423894 AA252356 CR592162 BC012764 AA992764 
    AI598116 AI498688 AU122612 BP376469 BX401584 BX350618 AI652427 BM980286 
    AI755062 AK024197 BU902362 AA633873 NM_031922 BC035286 BC021211 AA142952 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for REPS1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b · 16c ^
    SP1:                                                                          -                                   -     -           -                       -   
    SP2:                                                                          -                                   -     -           -                       -   
    SP3:                                                                          -     -                             -     -           -                       -   
    SP4:                                                                          -     -                       -     -     -     -     -                       -   
    SP5:                                                                                                                                -                           

    ExUns: 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for REPS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    REPS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    REPS1 Expression
    About this image

    REPS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REPS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.334603

    UniProtKB/Swiss-Prot: REPS1_HUMAN, Q96D71
    Tissue specificity: Widely expressed with highest levels in heart and testis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REPS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for REPS1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Reps11 , 5 RalBP1 associated Eps domain containing protein1, 5 90.31(n)1
    95.22(a)1
      10 (7.42 cM)5
    197071  NM_009048.21  NP_033074.21 
     180558615 
    chicken
    (Gallus gallus)
    Aves REPS11 RALBP1 associated Eps domain containing 1 85.07(n)
    89.82(a)
      421678  NM_001012877.1  NP_001012895.1 
    lizard
    (Anolis carolinensis)
    Reptilia REPS16
    RALBP1 associated Eps domain containing 1
    85(a)
    1 ↔ 1
    GL343200.1(944814-1015009)
    zebrafish
    (Danio rerio)
    Actinopterygii reps11 RALBP1 associated Eps domain containing 1 70.29(n)
    74.07(a)
      564535  NM_001045056.2  NP_001038521.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Reps6
    --
    21(a)
    1 → many
    2L(11100963-11106652)


    ENSEMBL Gene Tree for REPS1 (if available)
    TreeFam Gene Tree for REPS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for REPS1 gene
    EPS15L12  EHD32  REPS22  EHD22  EHD12  EHD42  ITSN12  EPS152  
    ITSN22  SRL2  
    3 SIMAP similar genes for REPS1 using alignment to 11 protein entries:     REPS1_HUMAN (see all proteins):
    EPS15L1    ITSN1    ITSN2

    Find genes that share paralogs with REPS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for REPS1 (see all 1852)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs117585021,2
    C,H--139225791(+) TTTCTA/GAAGAT 2 -- ut310--------
    rs793177201,2
    C--139225801(+) ATAGA-/ATAGA 
            
    TGCTT
    2 -- ut310--------
    rs1891498031,2
    --139225807(+) TAGAAC/TAGATG 2 -- ut310--------
    rs126191,2
    C,F,O,A,H--139225925(+) TATTAG/TCCATA 2 -- ut31 ese329Minor allele frequency- T:0.43MN NA NS EA WA CSA 3045
    rs1123178361,2
    C--139225937(+) AAGCAT/CTGCAT 2 -- ut312Minor allele frequency- C:0.08CSA WA 119
    rs1925382331,2
    C--139226170(+) TAAAAA/CCAAGT 2 -- ut310--------
    rs178564041,2
    H--139226208(+) ATAGGT/GGAGAG 4 /H /P mis1 ese34Minor allele frequency- G:0.00NS EA 420
    rs178564031,2
    H--139226211(+) GGTGAG/AAGAAT 4 /S /F mis1 ese34Minor allele frequency- A:0.00NS EA 420
    rs1844431961,2
    --139226452(+) AGTCTC/TGCTCT 2 -- int10--------
    rs624409521,2
    C,F--139226489(+) AATGGC/TGCAAT 2 -- int11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for REPS1 (139224630 - 139309398 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for REPS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732774CNV Deletion23290073
    esv272696CNV Insertion20981092
    esv268300CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing REPS1
    DNA2.0 Custom Variant and Variant Library Synthesis for REPS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614825    OMIM disorders: --


    Find genes that share disorders with REPS1           About GenesLikeMe


    Export disorders for REPS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for REPS1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with REPS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and characterization of a novel human REPS1 gene. (PubMed id 11750063)1, 2, 9 Xu J....Mao Y. (Biochim. Biophys. Acta 2001)
    2. Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits. (PubMed id 20946875)1, 2 Dergai O.... Rynditch A. (Biochem. Biophys. Res. Commun. 2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors. (PubMed id 12364336)1, 2 Cullis D.N.... Feig L.A. (J. Biol. Chem. 2002)
    6. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (PLoS ONE 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85021 HGNC: 15578 AceView: REPS1 Ensembl:ENSG00000135597 euGenes: HUgn85021
    ECgene: REPS1 H-InvDB: REPS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for REPS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for REPS1 gene:
    Search GeneIP for patents involving REPS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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