Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REPIN1 Gene

protein-coding   GIFtS: 44
GCID: GC07P150066

replication initiator 1

(Previous name: zinc finger protein 464 (RIP60) )
(Previous symbol: ZNF464)
 Explore 4 diseases affiliated with
REPIN1 via our new
 Human Malady Compendium 
Biological research products
for REPIN1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Replication Initiator 11 2     60 KDa Origin-Specific DNA-Binding Protein2 3
RIP601 2 3     60 KDa Replication Initiation Region Protein2 3
ZNF4641 2 3     ATT-Binding Protein2 3
AP41 2     DHFR Oribeta-Binding Protein RIP602 3
H_DJ0584D14.121 2     Replication Initiation Region Protein (60kD)2
Zfp4641 2     Zinc Finger Protein AP42
Zinc Finger Protein 464 (RIP60)1 2     Zinc Finger Protein 4643

External Ids:    HGNC: 179221   Entrez Gene: 298032   Ensembl: ENSG000002140227   UniProtKB: Q9BWE03   

Export aliases for REPIN1 gene to outside databases

Previous GC identifers: GC07P149380 GC07P149459 GC07P149505 GC07P149698 GC07P143882


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: REPI1_HUMAN, Q9BWE0
Function: Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication.
Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second,
homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending

Gene Wiki entry for REPIN1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REPIN1 gene promoter:
         NF-1   Sp1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): REPIN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for REPIN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REPIN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

REPIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REPIN1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P150066:  view genomic region     (about GC identifiers)

Start:
150,065,278 bp from pter      End:
150,071,133 bp from pter
Size:
5,856 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 149,403,728-149,408,982     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: REPI1_HUMAN, Q9BWE0 (See protein sequence)
Recommended Name: Replication initiator 1  
Size: 567 amino acids; 63575 Da
Subunit: Homodimers and homomultimers. Found in a complex with RIP60 and RIP100
Subcellular location: Nucleus
Sequence caution: Sequence=AAH00363.2; Type=Erroneous initiation; Sequence=AAS00386.1; Type=Erroneous gene model
prediction; Sequence=CAB53100.1; Type=Frameshift; Positions=8;
Secondary accessions: D3DWZ1 Q7LE03 Q9BUZ6 Q9NZH2 Q9UMP5

Explore the universe of human proteins at neXtProt for REPIN1: NX_Q9BWE0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BWE0

  • REPIN1 Protein expression data from MOPED and PaxDb:    About this image 
    REPIN1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001093165.1  NP_001093166.1  NP_037532.2  NP_055189.2  

    ENSEMBL proteins: 
     ENSP00000428562   ENSP00000420578   ENSP00000418507   ENSP00000417291   ENSP00000419789  
     ENSP00000417982   ENSP00000419872   ENSP00000418279   ENSP00000417756   ENSP00000428129  
     ENSP00000427721   ENSP00000417786   ENSP00000388287   ENSP00000445016   ENSP00000380451  
     ENSP00000407714  

    Human Recombinant Protein Products for REPIN1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 5): REPIN1
    OriGene Custom Protein Services for REPIN1 
    GenScript Custom Purified and Recombinant Proteins Services for REPIN1
    Novus Biologicals REPIN1 Protein
    Novus Biologicals REPIN1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for REPIN1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005664nuclear origin of replication recognition complex TAS10606657

    REPIN1 for ontologies           About GeneDecksing



    REPIN1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for REPIN1 
    GenScript Custom Superior Antibodies Services for REPIN1
    Novus Biologicals REPIN1 Antibodies
    Abcam antibodies for REPIN1 
    Uscn Antibodies for REPIN1
    ThermoFisher Antibodies for REPIN1

    Assay Products for REPIN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for REPIN1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for REPIN1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    REPIN1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BWE0

    ProtoNet protein and cluster: Q9BWE0

    UniProtKB/Swiss-Prot: REPI1_HUMAN, Q9BWE0
    Similarity: Contains 15 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REPI1_HUMAN, Q9BWE0
    Function: Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication.
    Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second,
    homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--
         
    REPIN1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for REPIN1 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 4): REPIN1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REPIN1
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate REPIN1 (see all 22):
    hsa-miR-137 hsa-miR-657 hsa-miR-4263 hsa-miR-520a-5p hsa-miR-3605-5p hsa-miR-525-3p hsa-miR-761 hsa-miR-3173-3p
    SwitchGear 3'UTR luciferase reporter plasmidREPIN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REPIN1 (see all 7)
    OriGene shRNA RFP: REPIN1
    OriGene siRNA: REPIN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REPIN1
    Sirion Biotech Custom design and validation of potent shRNA sequences against REPIN1 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for REPIN1
    Sirion Biotech Customized adenovirus for overexpression of REPIN1 
    Sirion Biotech Customized adenovirus for potent knockdown of REPIN1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REPIN1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REPIN1 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): REPIN1 (NM_013400)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REPIN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REPIN1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for REPIN1
    Search LifeMap BioReagents cell lines for REPIN1
    Sirion Biotech Customized stable knockdown cell line services for REPIN1 
    Sirion Biotech Customized inducible knockdown cell line services for REPIN1
    Sirion Biotech Customized stable overexpressing cell line services for REPIN1
    Sirion Biotech Customized inducible overexpressing cell line services for REPIN1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REPIN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for REPIN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/15 Interacting proteins for REPIN1 (Q9BWE02, 3 ENSP000003882874) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GATA3P237713, ENSP000003686324I2D: score=1 STRING: ENSP00000368632
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    HDAC2Q927693, ENSP000003813314I2D: score=1 STRING: ENSP00000381331
    GMNNO754963, ENSP000002300564I2D: score=1 STRING: ENSP00000230056
    HDAC3O153793, ENSP000003029674I2D: score=1 STRING: ENSP00000302967
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--

    REPIN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REPIN1
    Search CenterWatch for drugs/clinical trials and news about REPIN1 / REPI1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for REPIN1 gene (4 alternative transcripts): 
    NM_001099695.1  NM_001099696.2  NM_013400.3  NM_014374.3  

    Unigene Cluster for REPIN1:

    Replication initiator 1
    Hs.647086  [show with all ESTs]
    Unigene Representative Sequence: NM_013400
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000519397 ENST00000487455 ENST00000479668(uc003whd.2) ENST00000466559
    ENST00000489432 ENST00000475514 ENST00000473391 ENST00000482680 ENST00000488943
    ENST00000495535 ENST00000467980 ENST00000461637 ENST00000469309 ENST00000518514
    ENST00000522266 ENST00000518462 ENST00000486714 ENST00000425389(uc003whe.2)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 4): REPIN1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REPIN1
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate REPIN1 (see all 22):
    hsa-miR-137 hsa-miR-657 hsa-miR-4263 hsa-miR-520a-5p hsa-miR-3605-5p hsa-miR-525-3p hsa-miR-761 hsa-miR-3173-3p
    SwitchGear 3'UTR luciferase reporter plasmidREPIN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REPIN1 (see all 7)
    OriGene shRNA RFP: REPIN1
    OriGene siRNA: REPIN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REPIN1
    Sirion Biotech Custom design and validation of potent shRNA sequences against REPIN1 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REPIN1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REPIN1 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): REPIN1 (NM_013400)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REPIN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REPIN1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REPIN1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REPIN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REPIN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REPIN1

    Additional cDNA sequence: 

    AF201303.1 AJ245553.1 AK025356.1 AK225227.1 AK226081.1 AK292670.1 AL162065.1 BC000363.2 
    BC001760.1 

    24/25 DOTS entries (see all 25):

    DT.100649140  DT.448413  DT.95363491  DT.91906410  DT.121062885  DT.91760433  DT.100775335  DT.91760449 
    DT.91760442  DT.95129318  DT.100030724  DT.121062834  DT.75101354  DT.97769908  DT.100649138  DT.100767154 
    DT.121062813  DT.70100288  DT.102834501  DT.121062863  DT.418984  DT.435648  DT.100843198  DT.91643316 

    24/491 AceView cDNA sequences (see all 491):

    AI570541 BU687785 BG286860 BM068770 BM479010 AI598195 AI524705 BQ787965 
    AI440368 AA565815 AI383384 AW961073 AI768126 AI564087 AW573211 BX343432 
    BM856394 AI680299 CD673613 CB047663 CN480156 AI369489 AI140999 CF264827 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REPIN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCACGGCAAG
    REPIN1 Expression
    About this image
    See REPIN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REPIN1

    SOURCE GeneReport for Unigene cluster: Hs.647086
        SABiosciences Custom PCR Arrays for REPIN1

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REPIN1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REPIN1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REPIN1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REPIN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REPIN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for REPIN1 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Repin11 , 5 replication initiator 11, 5 84.09(n)1
    87.77(a)1
      6 (23.57 cM)5
    588871  NM_001079901.11  NP_001073370.21 
     485938835 


    ENSEMBL Gene Tree for REPIN1 (if available)
    TreeFam Gene Tree for REPIN1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for REPIN1 gene
    ZNF5792  
    18/217 SIMAP similar genes for REPIN1 using alignment to 11 protein entries:     REPI1_HUMAN (see all proteins) (see all similar genes):
    ZFS-5    kr-znf3    ZNF818P    ZNF232    ZNF167    ZNF826P
    ZNF787    ZNF808    ZNF78L1    ZNF514    ZFS-6    ZNF620
    ZSCAN23    ZNF    DKFZp686M04222    ZNF542    ZNF713    ZNF785

    REPIN1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for REPIN1
    PGOHUM00000250978


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/131 NCBI SNPs in REPIN1 are shown (see all 131    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887378891,2
    --150064059(+) ATAGAC/GTAAAG 3 -- us2k10--------
    rs1455501221,2
    --150064065(+) TAAAGC/TAAAAC 3 -- us2k10--------
    rs19834421,2
    --150064105(+) ccggaT/Ggcagt 3 -- us2k12Minor allele frequency- G:0.00NA 4
    rs19834431,2
    --150064119(+) tcacaT/Cctgta 3 -- us2k11Minor allele frequency- C:0.00NA 2
    rs117681081,2
    C,A,H--150064150(+) TGGGGC/TGGGAG 3 -- us2k13Minor allele frequency- T:0.32NA EA 242
    rs1916930531,2
    --150064160(+) GGATCA/GTTTGA 3 -- us2k10--------
    rs286816071,2
    C--150064278(+) AGGCCG/AAGGTG 3 -- us2k13Minor allele frequency- A:0.07CSA WA EA 240
    rs772606401,2
    F--150064306(+) CAGGAA/TGTCCT 3 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1170349771,2
    F--150064411(+) ACGAGG/AAAACA 3 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1831733791,2
    --150064663(+) TTTTTA/TAAAAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for REPIN1 (150065278 - 150071133 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for REPIN1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REPIN1
    DNA2.0 Custom Variant and Variant Library Synthesis for REPIN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    REPIN1 for disorders           About GeneDecksing

    4 diseases for REPIN1:    About MalaCards
    acrodermatitis enteropathica    enteropathica    acrodermatitis    immunodeficiency


    Export disorders for REPIN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REPIN1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with REPIN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The dhfr oribeta-binding protein RIP60 contains 15 zinc fingers: DNA binding and looping by the central three fingers and an associated proline-rich region. (PubMed id 10606657)1, 2, 3 Houchens C.R....Heintz N.H. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Condensation by DNA looping facilitates transfer of large DNA molecules into mammalian cells. (PubMed id 11328883)1, 2 Montigny W.J.... Heintz N.H. (2001)
    5. RIP60 dimers and multiples of dimers assemble link structures at an origin of bidirectional replication in the dihydrofolate reductase amplicon of Chinese hamster ovary cells. (PubMed id 8355269)1, 2 Mastrangelo I.A.... Heintz N.H. (1993)
    6. RIP60, a mammalian origin-binding protein, enhances DNA bending near the dihydrofolate reductase origin of replication. (PubMed id 2247056)1, 2 Caddle M.S.... Heintz N.H. (1990)
    7. Purification of RIP60 and RIP100, mammalian proteins with origin- specific DNA-binding and ATP-dependent DNA helicase activities. (PubMed id 2174103)1, 2 Dailey L.... Heintz N.H. (1990)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29803 HGNC: 17922 AceView: MGC33584andLOC155036 Ensembl:ENSG00000214022 euGenes: HUgn29803
    ECgene: REPIN1 H-InvDB: REPIN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REPIN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for REPIN1 gene:
    Search GeneIP for patents involving REPIN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for REPIN1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REPIN1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REPIN1  
     OriGene Protein Over-expression Lysate for REPIN1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for REPIN1   OriGene 3'-UTR Clone for REPIN1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REPIN1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REPIN1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for REPIN1   OriGene Custom Protein Services for REPIN1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat REPIN1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REPIN1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REPIN1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REPIN1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REPIN1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REPIN1
     GenScript Custom Purified and Recombinant Proteins Services for REPIN1 GenScript cDNA clones with any tag delivered in your preferred vector for REPIN1
     GenScript Custom Assay Services for REPIN1 GenScript Custom Superior Antibodies Services for REPIN1
     GenScript Custom overexpressing Cell Line Services for REPIN1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in REPIN1 promoter
     Search Chromatin IP Primers for REPIN1
     RT2 qPCR Primer Assay in human, mouse, rat REPIN1
     GNC Network for REPIN1
     SABiosciences Custom PCR Arrays for REPIN1
     Search Tocris compounds for REPIN1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     REPIN1 antibodies
     REPIN1 proteins
     REPIN1 lysates
     Antibodies for REPIN1
     See all of Abcam's Antibodies, Kits and Proteins for REPIN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     REPIN1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for REPIN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REPIN1
     SwitchGear 3'UTR luciferase reporter plasmids for REPIN1
     SwitchGear Promoter luciferase reporter plasmids for REPIN1
     ThermoFisher Antibodies for REPIN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REPIN1
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for REPIN1
    Sirion Biotech Customized:
     stable knockdown cell line services for REPIN1
     inducible knockdown cell line services for REPIN1
     design and validation of potent shRNA sequences against REPIN1
     adenovirus for potent knockdown of REPIN1
     adenovirus for overexpression of REPIN1
     stable overexpressing cell line services for REPIN1
     inducible overexpressing cell line services for REPIN1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      REPIN1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4