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Aliases for REP15 Gene

Aliases for REP15 Gene

  • RAB15 Effector Protein 2 3 5
  • RAB15EP 3

External Ids for REP15 Gene

Previous GeneCards Identifiers for REP15 Gene

  • GC12P027742
  • GC12P027849
  • GC12P027618

Summaries for REP15 Gene

Entrez Gene Summary for REP15 Gene

  • The protein encoded by this intronless gene interacts with GTP-bound Rab15 and is involved in recycling of transferrin receptor from the endocytic recycling compartment to the cell surface. [provided by RefSeq, Sep 2016]

GeneCards Summary for REP15 Gene

REP15 (RAB15 Effector Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for REP15 Gene

  • Regulates transferrin receptor recycling from the endocytic recycling compartment.

Additional gene information for REP15 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REP15 Gene

Genomics for REP15 Gene

GeneHancer (GH) Regulatory Elements for REP15 Gene

Promoters and enhancers for REP15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I027695 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.8 +0.5 462 2 SOX13 FOXA2 MAX ZNF384 CEBPG ZSCAN9 HNF4G SMARCC2 CREM GATAD2A REP15 MANSC4 KLHL42 ENSG00000276261 ENSG00000256377
GH12I027613 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 -79.1 -79148 6.9 PKNOX1 KLF17 SIN3A ZNF366 ZSCAN5C SCRT2 RCOR1 FOS CEBPB TSHZ1 SMCO2 ARNTL2-AS1 REP15 PPFIBP1 ENSG00000256377 ENSG00000256557 GC12P027690
GH12I027622 Enhancer 1 Ensembl ENCODE dbSUPER 10.8 -73.1 -73054 2.7 ZNF680 DPF2 FOXA1 E2F1 CTBP1 GATA3 JUND FOS FOSL2 TCF7L2 SMCO2 REP15 ENSG00000256557 GC12P027690 PPFIBP1
GH12I028126 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.5 +433.1 433100 6.8 HDGF SMAD1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 E2F8 ARID2 LOC105369710 CCDC91 REP15 PTHLH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around REP15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the REP15 gene promoter:

Genomic Locations for REP15 Gene

Genomic Locations for REP15 Gene
1,139 bases
Plus strand

Genomic View for REP15 Gene

Genes around REP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REP15 Gene

Proteins for REP15 Gene

  • Protein details for REP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rab15 effector protein
    Protein Accession:
    Secondary Accessions:
    • B2RU16

    Protein attributes for REP15 Gene

    236 amino acids
    Molecular mass:
    26571 Da
    Quaternary structure:
    • Interacts with the GTP-bound form of RAB15.
    • Sequence=AAT76304.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

neXtProt entry for REP15 Gene

Post-translational modifications for REP15 Gene

No Post-translational modifications

Other Protein References for REP15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for REP15 Gene

Domains & Families for REP15 Gene

Gene Families for REP15 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for REP15 Gene


Suggested Antigen Peptide Sequences for REP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with REP15: view

No data available for UniProtKB/Swiss-Prot for REP15 Gene

Function for REP15 Gene

Molecular function for REP15 Gene

UniProtKB/Swiss-Prot Function:
Regulates transferrin receptor recycling from the endocytic recycling compartment.

Gene Ontology (GO) - Molecular Function for REP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16195351
genes like me logo Genes that share ontologies with REP15: view
genes like me logo Genes that share phenotypes with REP15: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for REP15 Gene

Localization for REP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REP15 Gene

Early endosome membrane. Note=Colocalizes with RAB11 and RAB15 to the endocytic recycling compartment.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REP15 gene
Compartment Confidence
endosome 5
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for REP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0010008 endosome membrane IDA 16195351
GO:0016020 membrane IEA --
GO:0031901 early endosome membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 16195351
genes like me logo Genes that share ontologies with REP15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for REP15 Gene

Pathways & Interactions for REP15 Gene

SuperPathways for REP15 Gene

No Data Available

Interacting Proteins for REP15 Gene

Selected Interacting proteins: Q6BDI9-REP15_HUMAN for REP15 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for REP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001881 receptor recycling IMP 16195351
GO:0033572 transferrin transport IDA 16195351
genes like me logo Genes that share ontologies with REP15: view

No data available for Pathways by source and SIGNOR curated interactions for REP15 Gene

Drugs & Compounds for REP15 Gene

(1) Drugs for REP15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with REP15: view

Transcripts for REP15 Gene

mRNA/cDNA for REP15 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for REP15 Gene

RAB15 effector protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for REP15 Gene

No ASD Table

Relevant External Links for REP15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for REP15 Gene

mRNA differential expression in normal tissues according to GTEx for REP15 Gene

This gene is overexpressed in Colon - Transverse (x13.0) and Stomach (x8.4).

Protein differential expression in normal tissues from HIPED for REP15 Gene

This gene is overexpressed in Fetal Brain (31.4), Monocytes (15.1), Frontal cortex (10.4), and CD4 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for REP15 Gene

NURSA nuclear receptor signaling pathways regulating expression of REP15 Gene:


SOURCE GeneReport for Unigene cluster for REP15 Gene:

genes like me logo Genes that share expression patterns with REP15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for REP15 Gene

Orthologs for REP15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for REP15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia REP15 33 34
  • 99.58 (n)
(Canis familiaris)
Mammalia REP15 33
  • 88.14 (n)
(Bos Taurus)
Mammalia REP15 33 34
  • 84.48 (n)
(Mus musculus)
Mammalia Rep15 33 16 34
  • 79.28 (n)
(Rattus norvegicus)
Mammalia Rep15 33
  • 79.13 (n)
(Anolis carolinensis)
Reptilia REP15 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rep15 33
  • 59.1 (n)
Species where no ortholog for REP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for REP15 Gene

Gene Tree for REP15 (if available)
Gene Tree for REP15 (if available)

Paralogs for REP15 Gene

No data available for Paralogs for REP15 Gene

Variants for REP15 Gene

Sequence variations from dbSNP and Humsavar for REP15 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000292166 -- 27,695,265(+) T/C upstream_transcript_variant
rs1002957214 -- 27,696,892(+) A/G coding_sequence_variant, synonymous_variant
rs1003544705 -- 27,697,752(+) T/C downstream_transcript_variant
rs1003596963 -- 27,697,976(+) G/C/T downstream_transcript_variant
rs1004034352 -- 27,696,200(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for REP15 Gene

Variant ID Type Subtype PubMed ID
esv2745664 CNV deletion 23290073
esv2761729 CNV gain 21179565
nsv469178 CNV gain 19166990
nsv557823 CNV gain 21841781
nsv832358 CNV gain 17160897

Variation tolerance for REP15 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REP15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REP15 Gene

Disorders for REP15 Gene

Additional Disease Information for REP15

No disorders were found for REP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REP15 Gene

Publications for REP15 Gene

  1. Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment. (PMID: 16195351) Strick DJ … Elferink LA (Molecular biology of the cell 2005) 2 3 4 22 58
  2. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A … Levine B (Nature 2011) 3 58
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58
  4. Functional properties of rab15 effector protein in endocytic recycling. (PMID: 16473635) Elferink LA … Strick DJ (Methods in enzymology 2005) 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for REP15 Gene

Sources for REP15 Gene

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