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Aliases for REP15 Gene

Aliases for REP15 Gene

  • RAB15 Effector Protein 2 3 5
  • RAB15EP 3

External Ids for REP15 Gene

Previous GeneCards Identifiers for REP15 Gene

  • GC12P027742
  • GC12P027849
  • GC12P027618

Summaries for REP15 Gene

Entrez Gene Summary for REP15 Gene

  • REP15 is a binding partner of the RAB GTPase family member RAB15 that facilitates transferrin receptor (TFRC; MIM 190010) recycling from the endocytic recycling compartment (Strick and Elferink, 2005 [PubMed 16195351]).[supplied by OMIM, Mar 2008]

GeneCards Summary for REP15 Gene

REP15 (RAB15 Effector Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for REP15 Gene

  • Regulates transferrin receptor recycling from the endocytic recycling compartment.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REP15 Gene

Genomics for REP15 Gene

Regulatory Elements for REP15 Gene

Enhancers for REP15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around REP15 on UCSC Golden Path with GeneCards custom track

Genomic Location for REP15 Gene

27,696,495 bp from pter
27,697,633 bp from pter
1,139 bases
Plus strand

Genomic View for REP15 Gene

Genes around REP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REP15 Gene

Proteins for REP15 Gene

  • Protein details for REP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rab15 effector protein
    Protein Accession:
    Secondary Accessions:
    • B2RU16

    Protein attributes for REP15 Gene

    236 amino acids
    Molecular mass:
    26571 Da
    Quaternary structure:
    • Interacts with the GTP-bound form of RAB15.
    • Sequence=AAT76304.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

neXtProt entry for REP15 Gene

Proteomics data for REP15 Gene at MOPED

Post-translational modifications for REP15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REP15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for REP15 Gene

Domains & Families for REP15 Gene

Protein Domains for REP15 Gene


Suggested Antigen Peptide Sequences for REP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with REP15: view

No data available for Gene Families and UniProtKB/Swiss-Prot for REP15 Gene

Function for REP15 Gene

Molecular function for REP15 Gene

UniProtKB/Swiss-Prot Function:
Regulates transferrin receptor recycling from the endocytic recycling compartment.
genes like me logo Genes that share phenotypes with REP15: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for REP15 Gene

Localization for REP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REP15 Gene

Early endosome membrane. Note=Colocalizes with RAB11 and RAB15 to the endocytic recycling compartment.

Subcellular locations from

Jensen Localization Image for REP15 Gene COMPARTMENTS Subcellular localization image for REP15 gene
Compartment Confidence
endosome 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for REP15 Gene

Pathways & Interactions for REP15 Gene

SuperPathways for REP15 Gene

No Data Available

Interacting Proteins for REP15 Gene

Gene Ontology (GO) - Biological Process for REP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033572 transferrin transport IDA 16195351
genes like me logo Genes that share ontologies with REP15: view

No data available for Pathways by source and SIGNOR curated interactions for REP15 Gene

Drugs & Compounds for REP15 Gene

(1) Drugs for REP15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with REP15: view

Transcripts for REP15 Gene

mRNA/cDNA for REP15 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for REP15 Gene

RAB15 effector protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for REP15 Gene

No ASD Table

Relevant External Links for REP15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REP15 Gene

mRNA expression in normal human tissues for REP15 Gene

mRNA differential expression in normal tissues according to GTEx for REP15 Gene

This gene is overexpressed in Colon - Transverse (x13.0) and Stomach (x8.4).

Protein differential expression in normal tissues from HIPED for REP15 Gene

This gene is overexpressed in Fetal Brain (31.4), Monocytes (15.1), Frontal cortex (10.4), and CD4 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for REP15 Gene

SOURCE GeneReport for Unigene cluster for REP15 Gene Hs.269836

genes like me logo Genes that share expression patterns with REP15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for REP15 Gene

Orthologs for REP15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for REP15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia REP15 35
  • 84.48 (n)
  • 81.03 (a)
REP15 36
  • 81 (a)
(Canis familiaris)
Mammalia REP15 35
  • 88.14 (n)
  • 84.75 (a)
(Mus musculus)
Mammalia Rep15 35
  • 79.28 (n)
  • 74.78 (a)
Rep15 16
Rep15 36
  • 75 (a)
(Pan troglodytes)
Mammalia REP15 35
  • 99.58 (n)
  • 99.15 (a)
REP15 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rep15 35
  • 79.13 (n)
  • 74.78 (a)
(Anolis carolinensis)
Reptilia REP15 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rep15 35
  • 59.1 (n)
  • 48.91 (a)
Species with no ortholog for REP15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for REP15 Gene

Gene Tree for REP15 (if available)
Gene Tree for REP15 (if available)

Paralogs for REP15 Gene

No data available for Paralogs for REP15 Gene

Variants for REP15 Gene

Sequence variations from dbSNP and Humsavar for REP15 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs929949 - 27,696,863(+) GATCC(A/G)ACAAG reference, missense
rs12819160 - 27,697,180(+) ACTGA(A/T)GATTG reference, missense
rs929948 -- 27,696,862(+) GGATC(C/T)AACAA reference, synonymous-codon
rs112912409 -- 27,697,363(+) AGCAT(A/G)GGATT utr-variant-3-prime
rs199929786 -- 27,696,786(+) TGAGT(A/G)GCTGA reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for REP15 Gene

Variant ID Type Subtype PubMed ID
esv2745664 CNV Deletion 23290073
nsv832358 CNV Gain 17160897
nsv469178 CNV Gain 19166990

Variation tolerance for REP15 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for REP15 Gene

Disorders for REP15 Gene

Relevant External Links for REP15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for REP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REP15 Gene

Publications for REP15 Gene

  1. Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment. (PMID: 16195351) Strick D.J. … Elferink L.A. (Mol. Biol. Cell 2005) 2 3 4 23 67
  2. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3
  3. Functional properties of rab15 effector protein in endocytic recycling. (PMID: 16473635) Elferink L.A. … Strick D.J. (Meth. Enzymol. 2005) 23
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for REP15 Gene

Sources for REP15 Gene