Aliases for RENBP Gene
External Ids for RENBP Gene
Previous GeneCards Identifiers for RENBP Gene
The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]
GeneCards Summary for RENBP Gene
RENBP (Renin Binding Protein) is a Protein Coding gene. Diseases associated with RENBP include Wilms Tumor Susceptibility-5 and Hypertension, Essential. Among its related pathways are Amino sugar and nucleotide sugar metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include protein homodimerization activity and enzyme inhibitor activity.
UniProtKB/Swiss-Prot for RENBP Gene
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.