Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RENBP Gene

protein-coding   GIFtS: 62
GCID: GC0XM153200

Renin Binding Protein

(Previous name: renin-binding protein)
  See RENBP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Renin Binding Protein1 2     AGE2 3
GlcNAc 2-Epimerase1 2 3     EC 5.1.3.83 8
N-Acetyl-D-Glucosamine 2-Epimerase1 2 3     RBP2
Renin-Binding Protein1 3     RNBP2
N-Acylglucosamine 2-Epimerase1 2     RnBP3

External Ids:    HGNC: 99591   Entrez Gene: 59732   Ensembl: ENSG000001020327   OMIM: 3124205   UniProtKB: P516063   

Export aliases for RENBP gene to outside databases

Previous GC identifers: GC0XM147338 GC0XM149655 GC0XM150786 GC0XM151668 GC0XM152721 GC0XM152853 GC0XM141853


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RENBP Gene:
The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight
renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin.
The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that
it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the
literature. (provided by RefSeq, Jul 2008)

GeneCards Summary for RENBP Gene:
RENBP (renin binding protein) is a protein-coding gene. Diseases associated with RENBP include toxocariasis, and essential hypertension. GO annotations related to this gene include mannose-6-phosphate isomerase activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: RENBP_HUMAN, P51606
Function: Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a
protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the
N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of
Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded

Gene Wiki entry for RENBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RENBP gene promoter:
         AhR   SRY   Elk-1   Sp1   CUTL1   Tal-1beta   ITF-2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRENBP promoter sequence
   Search Chromatin IP Primers for RENBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RENBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

RENBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RENBP gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM153200:  view genomic region     (about GC identifiers)

Start:
153,200,716 bp from pter      End:
153,210,232 bp from pter
Size:
9,517 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RENBP_HUMAN, P51606 (See protein sequence)
Recommended Name: N-acylglucosamine 2-epimerase  
Size: 427 amino acids; 48831 Da
Subunit: Homodimer
Caution: It is uncertain whether Met-1 or Met-11 is the initiator
Sequence caution: Sequence=AAH15558.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA01082.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA01082.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence;
Secondary accessions: B4DNZ3 Q96BI6
Alternative splicing: 2 isoforms:  P51606-1   P51606-2   

Explore the universe of human proteins at neXtProt for RENBP: NX_P51606

Explore proteomics data for RENBP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for RENBP (P51606)
     YAELGDWC  MAVPMMLL  EAMIAFLMGY 


    See RENBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002901.2  
    ENSEMBL proteins: 
     ENSP00000377303   ENSP00000405759   ENSP00000359014   ENSP00000394220   ENSP00000409034  
     ENSP00000399278   ENSP00000387811  

    RENBP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RENBP
    GenScript Custom Purified and Recombinant Proteins Services for RENBP
    Novus Biologicals RENBP Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RENBP

     
    Search eBioscience for Proteins for RENBP 

    RENBP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RENBP
    Novus Biologicals RENBP Antibodies
    Abcam antibodies for RENBP
    Cloud-Clone Corp. Antibodies for RENBP
    Search ThermoFisher Antibodies for RENBP
    LSBio Antibodies in human, mouse, rat for RENBP

    RENBP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RENBP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RENBP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RENBP
    Cloud-Clone Corp. CLIAs for RENBP
    Search eBioscience for ELISAs for RENBP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR012341 6hp_glycosidase
     IPR008928 6-hairpin_glycosidase-like

    Graphical View of Domain Structure for InterPro Entry P51606

    ProtoNet protein and cluster: P51606

    1 Blocks protein domain: IPB010819 N-acylglucosamine 2-epimerase

    UniProtKB/Swiss-Prot: RENBP_HUMAN, P51606
    Similarity: Belongs to the N-acylglucosamine 2-epimerase family


    Find genes that share domains with RENBP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RENBP_HUMAN, P51606
    Function: Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a
    protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the
    N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of
    Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded
    Catalytic activity: N-acyl-D-glucosamine = N-acyl-D-mannosamine

         Genatlas biochemistry entry for RENBP:
    renin binding protein,involved in the regulation of the renin-angiotensin system

         Enzyme Number (IUBMB): EC 5.1.3.81 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004857enzyme inhibitor activity ----
    GO:0004866endopeptidase inhibitor activity TAS9285790
    GO:0005524ATP binding IEA--
    GO:0017076purine nucleotide binding ----
         
    Find genes that share ontologies with RENBP           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Renbp):
     homeostasis/metabolism  renal/urinary system 

    Find genes that share phenotypes with RENBP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Renbptm1Csch for RENBP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RENBP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RENBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RENBP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RENBP

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat RENBP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RENBP
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RENBP
    Predesigned siRNA for gene silencing in human, mouse, rat RENBP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RENBP

    Clone
    Products:
         
    OriGene clones in human, mouse for RENBP (see all 12)
    OriGene ORF clones in mouse, rat for RENBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RENBP (NM_002910)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RENBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RENBP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RENBP
    Browse ESI BIO Cell Lines and PureStem Progenitors for RENBP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RENBP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with RENBP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RENBP About    
    See pathways by source

    SuperPathContained pathways About
    1Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism


    Find genes that share SuperPaths with RENBP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for RENBP):
        Amino sugar and nucleotide sugar metabolism

    UniProtKB/Swiss-Prot: RENBP_HUMAN, P51606
    Pathway: Amino-sugar metabolism; N-acetylneuraminate degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RENBP
    Interactions:

        GeneGlobe Interaction Network for RENBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for RENBP (P516062, 3 ENSP000003773034) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBED1O960062, 3, ENSP000003706164MINT-68359 I2D: score=5 STRING: ENSP00000370616
    RENP007973, ENSP000002721904I2D: score=1 STRING: ENSP00000272190
    GNEENSP000003798394STRING: ENSP00000379839
    HEXAENSP000002680974STRING: ENSP00000268097
    HEXBENSP000002614164STRING: ENSP00000261416
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006044N-acetylglucosamine metabolic process IEA--
    GO:0006051N-acetylmannosamine metabolic process IEA--
    GO:0008217regulation of blood pressure TAS9285790
    GO:0010951negative regulation of endopeptidase activity ----
    GO:0019262N-acetylneuraminate catabolic process TAS--

    Find genes that share ontologies with RENBP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RENBP

    3 HMDB Compounds for RENBP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    N-Acetyl-D-glucosamine2-(acetylamino)-2-deoxyhexose (see all 9)7512-17-6--
    N-Acetylmannosamine2-Acetamido-2-deoxy-D-mannose (see all 3)3615-17-6--

    1 DrugBank Compound for RENBP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Acetyl-D-glucosamine2-Acetamido-2-deoxy-D-glucose (see all 4)7512-17-6target--16011304 17349707 17565386 17292397

    8 Novoseek inferred chemical compound relationships for RENBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-acetylglucosamine 72.7 24 16011304 (2), 11275551 (2), 11926999 (2), 10502668 (2) (see all 9)
    mannose 6-phosphate 48.5 1 8735181 (1)
    sialic acid 40 7 12499362 (3), 19707758 (2), 15987957 (1)
    rapamycin 23.4 1 1563628 (1)
    leucine 15.7 4 1723410 (3)
    atp 5.16 8 11926999 (1), 11726282 (1), 9990133 (1)
    cysteine 2.31 4 10502668 (2), 11275551 (1)
    serine 0 1 11275551 (1)



    Find genes that share compounds with RENBP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RENBP gene: 
    NM_002910.5  

    Unigene Cluster for RENBP:

    Renin binding protein
    Hs.158331  [show with all ESTs]
    Unigene Representative Sequence: NM_002910
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393700 ENST00000457282 ENST00000369997 ENST00000423624 ENST00000451114
    ENST00000442361 ENST00000462086 ENST00000464227 ENST00000471056 ENST00000475904
    ENST00000412763(uc004fjo.2 uc011mzh.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RENBP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RENBP
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RENBP
    Predesigned siRNA for gene silencing in human, mouse, rat RENBP
    Clone
    Products:
         
    OriGene clones in human, mouse for RENBP (see all 12)
    OriGene ORF clones in mouse, rat for RENBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RENBP (NM_002910)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RENBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RENBP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RENBP
    OriGene qSTAR qPCR primer pairs in human, mouse for RENBP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RENBP
      QuantiTect SYBR Green Assays in human, mouse, rat RENBP
      QuantiFast Probe-based Assays in human, mouse, rat RENBP

    Additional mRNA sequence: 

    AK298125.1 BC015558.2 D10232.1 

    5 DOTS entries:

    DT.91695494  DT.100023512  DT.99997872  DT.100746718  DT.121317632 

    Selected AceView cDNA sequences (see all 45):

    CD368393 CA976102 BU784500 BI753232 BQ683160 BI822024 BM719661 BM675574 
    BX280654 BQ002857 CR601292 BU784428 CA308512 BC015558 BQ876602 BX371652 
    BG910783 BQ883943 BQ676316 BX390368 BE277254 NM_002910 BI908480 D10232 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RENBP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                                          
    SP2:                                                  -           -                           
    SP3:                                                                                          


    ECgene alternative splicing isoforms for RENBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RENBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RENBP Expression
    About this image


    RENBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
    RENBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RENBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158331
        Custom PCR Arrays for RENBP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RENBP
    OriGene qSTAR qPCR primer pairs in human, mouse for RENBP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RENBP
    QuantiTect SYBR Green Assays in human, mouse, rat RENBP
    QuantiFast Probe-based Assays in human, mouse, rat RENBP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RENBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for RENBP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Renbp1 , 5 renin binding protein1, 5 84.63(n)1
    85.85(a)1
      X (37.49 cM)5
    197031  NM_023132.31  NP_075621.31 
     739221215 
    lizard
    (Anolis carolinensis)
    Reptilia RENBP6
    renin binding protein
    66(a)
    1 ↔ 1
    2(88341111-88358465)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237592 Xenopus laevis transcribed sequence with weak similarity more 75.42(n)    CF519989.1 
    zebrafish
    (Danio rerio)
    Actinopterygii renbp1 renin binding protein 63.87(n)
    62.85(a)
      791728  NM_001126443.1  NP_001119915.1 


    ENSEMBL Gene Tree for RENBP (if available)
    TreeFam Gene Tree for RENBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RENBP gene
    4 SIMAP similar genes for RENBP using alignment to 6 protein entries:     RENBP_HUMAN (see all proteins):
    UTY    NF2    ZNF564    AURA2

    Find genes that share paralogs with RENBP           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RENBP
    PGOHUM00000242089


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RENBP (see all 200)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999196631,2
    --153202694(+) ATAAA-/TAAAAA 2 -- int10--------
    rs568211101,2
    C--153202697(+) ATAAA-/TAAA/TAAATAA
    A
    /TAAATAAATAAA
    AACTA
    4 -- int1 cds10--------
    rs1463608691,2
    C--153202706(+) TAGTTA/CTGTGT 2 -- int10--------
    rs1824080371,2
    --153202738(+) TTACAC/TTGTTC 2 -- int10--------
    rs1397768911,2
    C--153203077(+) TATTTA/TTTTTA 2 -- int10--------
    rs1858832801,2
    --153203139(+) TTCCCA/GGGTTC 2 -- int10--------
    rs1117850601,2
    C,F--153203337(+) GCCACT/CGCGAC 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs48984631,2
    C,A--153203390(+) tgttgG/Accagg 2 -- int11Minor allele frequency- A:0.00NA 1
    rs1917777611,2
    --153203628(+) TAGCTA/GCAGGT 2 -- int10--------
    rs1486166071,2
    C--153203785(+) ACTCAC/TAATGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for RENBP (153200716 - 153210232 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RENBP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33199CNV Gain+Loss17666407
    nsv469867CNV Complex16826518

    Locus Specific Mutation Databases (LSDB): RENBP

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RENBP
    DNA2.0 Custom Variant and Variant Library Synthesis for RENBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 312420    OMIM disorders: --

    2 diseases for RENBP:    
    About MalaCards
    toxocariasis    essential hypertension

    2 diseases from the University of Copenhagen DISEASES database for RENBP:
    Allergic rhinitis     Toxocariasis

    Find genes that share disorders with RENBP           About GenesLikeMe

    3 Novoseek inferred disease relationships for RENBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilms tumor 35.1 1 1587805 (1)
    essential hypertension 20.5 1 9285790 (1)
    renal disease 0 1 8897555 (1)

    Genetic Association Database (GAD): RENBP
    Human Genome Epidemiology (HuGE) Navigator: RENBP (6 documents)

    Export disorders for RENBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RENBP gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with RENBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif. (PubMed id 1723410)1, 2, 9 Inoue H.... Miyake Y. (J. Biochem. 1991)
    2. Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2- epimerase. (PubMed id 9990133)1, 2, 9 Takahashi S....Kobayashi M. (J. Biochem. 1999)
    3. Human renin binding protein: complete genomic sequence and association of an intronic T/C polymorphism with the prorenin level in males. (PubMed id 9285790)1, 4, 9 KnAPll A....Rosenthal A. (Hum. Mol. Genet. 1997)
    4. The human gene for renin-binding protein. (PubMed id 1618798)1, 3, 9 Takahashi S....Miyake Y. (J. Biol. Chem. 1992)
    5. Angiotensin converting enzyme DD genotype is associated with hypertensive crisis. (PubMed id 12394950)1, 4, 9 Sunder-Plassmann G....FAPdinger M. (Crit. Care Med. 2002)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Analysis of several hundred genetic polymorphisms may improve assessment of the individual genetic burden for coronary artery disease. (PubMed id 12446192)1, 4 Ortlepp J.R....Hoffmann R. (Eur. J. Intern. Med. 2002)
    9. Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein). (PubMed id 11098137)1, 9 Takahashi S....Kawamura Y. (J. Biochem. 2000)
    10. Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein). (PubMed id 11926999)1, 9 Takahashi S....Mori K. (J. Biochem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5973 HGNC: 9959 AceView: RENBP Ensembl:ENSG00000102032 euGenes: HUgn5973
    ECgene: RENBP Kegg: 5973 H-InvDB: RENBP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RENBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RENBP gene:
    Search GeneIP for patents involving RENBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RENBP  
     OriGene qPCR primer pairs and template standards for RENBP   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RENBP  
     OriGene qSTAR qPCR primer pairs in human, mouse for RENBP   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RENBP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RENBP   OriGene Custom Protein Services for RENBP  

     
     
     Block miRNA regulation of human, mouse, rat RENBP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RENBP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RENBP Predesigned siRNA for gene silencing in human, mouse, rat RENBP
     QuantiFast Probe-based Assays in human, mouse, rat RENBP QuantiTect SYBR Green Assays in human, mouse, rat RENBP
     Custom PCR Arrays for RENBP Search Chromatin IP Primers for RENBP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RENBP  GeneGlobe Interaction Network for RENBP
     Regulatory tfbs in RENBP promoter
     GenScript Custom Purified and Recombinant Proteins Services for RENBP GenScript cDNA clones with any tag delivered in your preferred vector for RENBP
     GenScript Custom Assay Services for RENBP GenScript Custom overexpressing Cell Line Services for RENBP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RENBP
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RENBP antibodies
     RENBP proteins
     Antibodies for RENBP
     See all of Abcam's Antibodies, Kits and Proteins for RENBP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RENBP
     Antibodies for RENBP
     ELISAs for RENBP
     CLIAs for RENBP



     Browse ESI BIO Cell Lines and PureStem Progenitors for RENBP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RENBP
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RENBP
     SwitchGear Promoter luciferase reporter plasmids for RENBP
     Search ThermoFisher Antibodies for RENBP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RENBP
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RENBP
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RENBP
     LSBio Antibodies in human, mouse, rat for RENBP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RENBP
      Search eBioscience for proteins for RENBP
      Search eBioscience for elisas for RENBP
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RENBP gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4