Aliases for RENBP Gene
External Ids for RENBP Gene
Previous GeneCards Identifiers for RENBP Gene
The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]
GeneCards Summary for RENBP Gene
RENBP (Renin Binding Protein) is a Protein Coding gene. Diseases associated with RENBP include Wilms Tumor Susceptibility-5 and Hypertension, Essential. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Transport to the Golgi and subsequent modification. GO annotations related to this gene include protein homodimerization activity and enzyme inhibitor activity.
UniProtKB/Swiss-Prot for RENBP Gene
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.