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Aliases for RENBP Gene

Aliases for RENBP Gene

  • Renin Binding Protein 2 3 5
  • N-Acetyl-D-Glucosamine 2-Epimerase 2 3 4
  • GlcNAc 2-Epimerase 2 3 4
  • Renin-Binding Protein 2 4
  • EC 5.1.3.8 4 63
  • RNBP 3 4
  • AGE 3 4
  • N-Acylglucosamine 2-Epimerase 2
  • RBP 3

External Ids for RENBP Gene

Previous GeneCards Identifiers for RENBP Gene

  • GC0XM147338
  • GC0XM149655
  • GC0XM150786
  • GC0XM151668
  • GC0XM152721
  • GC0XM152853
  • GC0XM153200
  • GC0XM141853

Summaries for RENBP Gene

Entrez Gene Summary for RENBP Gene

  • The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]

GeneCards Summary for RENBP Gene

RENBP (Renin Binding Protein) is a Protein Coding gene. Diseases associated with RENBP include Hypertension, Essential. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include protein homodimerization activity and enzyme inhibitor activity.

UniProtKB/Swiss-Prot for RENBP Gene

  • Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.

Gene Wiki entry for RENBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RENBP Gene

Genomics for RENBP Gene

Regulatory Elements for RENBP Gene

Enhancers for RENBP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RENBP on UCSC Golden Path with GeneCards custom track

Promoters for RENBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RENBP on UCSC Golden Path with GeneCards custom track

Genomic Location for RENBP Gene

Chromosome:
X
Start:
153,935,263 bp from pter
End:
153,944,780 bp from pter
Size:
9,518 bases
Orientation:
Minus strand

Genomic View for RENBP Gene

Genes around RENBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RENBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RENBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RENBP Gene

Proteins for RENBP Gene

  • Protein details for RENBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51606-RENBP_HUMAN
    Recommended name:
    N-acylglucosamine 2-epimerase
    Protein Accession:
    P51606
    Secondary Accessions:
    • B4DNZ3
    • Q96BI6

    Protein attributes for RENBP Gene

    Size:
    427 amino acids
    Molecular mass:
    48831 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH15558.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA01082.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA01082.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for RENBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RENBP Gene

Proteomics data for RENBP Gene at MOPED

Selected DME Specific Peptides for RENBP Gene

Post-translational modifications for RENBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RENBP Gene

Domains & Families for RENBP Gene

Protein Domains for RENBP Gene

Suggested Antigen Peptide Sequences for RENBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51606

UniProtKB/Swiss-Prot:

RENBP_HUMAN :
  • Belongs to the N-acylglucosamine 2-epimerase family.
Family:
  • Belongs to the N-acylglucosamine 2-epimerase family.
genes like me logo Genes that share domains with RENBP: view

No data available for Gene Families for RENBP Gene

Function for RENBP Gene

Molecular function for RENBP Gene

GENATLAS Biochemistry:
renin binding protein,involved in the regulation of the renin-angiotensin system
UniProtKB/Swiss-Prot CatalyticActivity:
N-acyl-D-glucosamine = N-acyl-D-mannosamine.
UniProtKB/Swiss-Prot Function:
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.

Enzyme Numbers (IUBMB) for RENBP Gene

Gene Ontology (GO) - Molecular Function for RENBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IEA --
genes like me logo Genes that share ontologies with RENBP: view
genes like me logo Genes that share phenotypes with RENBP: view

Human Phenotype Ontology for RENBP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RENBP Gene

MGI Knock Outs for RENBP:

Animal Model Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for RENBP Gene

Localization for RENBP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RENBP Gene COMPARTMENTS Subcellular localization image for RENBP gene
Compartment Confidence
extracellular 5
cytosol 4
cytoskeleton 2
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RENBP Gene

Pathways & Interactions for RENBP Gene

genes like me logo Genes that share pathways with RENBP: view

UniProtKB/Swiss-Prot P51606-RENBP_HUMAN

  • Pathway: Amino-sugar metabolism; N-acetylneuraminate degradation.

Interacting Proteins for RENBP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000377303%0d%0a9606.ENSP00000272190%0d%0a9606.ENSP00000370616%0d%0a
Selected Interacting proteins: P51606-RENBP_HUMAN ENSP00000377303 for RENBP Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for RENBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006048 UDP-N-acetylglucosamine biosynthetic process TAS --
GO:0006051 N-acetylmannosamine metabolic process IEA --
GO:0008152 metabolic process IEA --
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with RENBP: view

No data available for SIGNOR curated interactions for RENBP Gene

Drugs & Compounds for RENBP Gene

(7) Drugs for RENBP Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved Nutra Target 0
Adenosine triphosphate Approved Nutra 0

(4) Additional Compounds for RENBP Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylmannosamine
  • 2-Acetamido-2-deoxy-D-mannopyranose
  • 2-Acetamido-2-deoxy-D-mannose
  • ManNAc
  • N-Acetyl-D-mannosamine
  • N-Acetylmannosamine
3615-17-6
genes like me logo Genes that share compounds with RENBP: view

Transcripts for RENBP Gene

Unigene Clusters for RENBP Gene

Renin binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RENBP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: - -
SP3:

Relevant External Links for RENBP Gene

GeneLoc Exon Structure for
RENBP
ECgene alternative splicing isoforms for
RENBP

Expression for RENBP Gene

mRNA expression in normal human tissues for RENBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RENBP Gene

This gene is overexpressed in Spleen (x5.9) and Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for RENBP Gene

This gene is overexpressed in Serum (33.8), Peripheral blood mononuclear cells (8.8), and Spleen (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RENBP Gene



SOURCE GeneReport for Unigene cluster for RENBP Gene Hs.158331

genes like me logo Genes that share expression patterns with RENBP: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RENBP Gene

Orthologs for RENBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for RENBP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RENBP 35
  • 86.33 (n)
  • 84.41 (a)
RENBP 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RENBP 35
  • 87.48 (n)
  • 88.54 (a)
RENBP 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Renbp 35
  • 84.63 (n)
  • 85.85 (a)
Renbp 16
Renbp 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RENBP 35
  • 99.69 (n)
  • 99.53 (a)
RENBP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Renbp 35
  • 84.75 (n)
  • 86 (a)
oppossum
(Monodelphis domestica)
Mammalia RENBP 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RENBP 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RENBP 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia renbp 35
  • 65.99 (n)
  • 64.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23759 35
zebrafish
(Danio rerio)
Actinopterygii renbp 35
  • 63.87 (n)
  • 62.85 (a)
renbp 36
  • 62 (a)
OneToOne
Species with no ortholog for RENBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RENBP Gene

ENSEMBL:
Gene Tree for RENBP (if available)
TreeFam:
Gene Tree for RENBP (if available)

Paralogs for RENBP Gene

(4) SIMAP similar genes for RENBP Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RENBP Gene

genes like me logo Genes that share paralogs with RENBP: view

No data available for Paralogs for RENBP Gene

Variants for RENBP Gene

Sequence variations from dbSNP and Humsavar for RENBP Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2229241 - 153,943,036(-) GGTGC(A/G)GGAGG reference, missense
rs2269371 - 153,941,572(+) ACTTG(C/T)CAATC reference, missense
rs762656 -- 153,946,200(+) TTCAC(A/G)TTCAT upstream-variant-2KB
rs2156929 -- 153,939,917(+) CCCCA(A/C)CACCA intron-variant
rs2269372 -- 153,942,092(+) ACCCA(A/G)CTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RENBP Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
nsv469867 CNV Complex 16826518

Variation tolerance for RENBP Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RENBP Gene

Disorders for RENBP Gene

MalaCards: The human disease database

(1) MalaCards diseases for RENBP Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
hypertension, essential
  • hypertension, essential 3
- elite association - COSMIC cancer census association via MalaCards
Search RENBP in MalaCards View complete list of genes associated with diseases

Relevant External Links for RENBP

Genetic Association Database (GAD)
RENBP
Human Genome Epidemiology (HuGE) Navigator
RENBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RENBP
genes like me logo Genes that share disorders with RENBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RENBP Gene

Publications for RENBP Gene

  1. Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif. (PMID: 1723410) Inoue H. … Miyake Y. (J. Biochem. 1991) 3 4 23 67
  2. Amino acid residues conferring the nucleotide binding properties of N-acetyl-D-glucosamine 2-epimerase (renin binding protein). (PMID: 16011304) Takahashi S. … Sugiyama T. (Biomed. Res. 2005) 23 25 26
  3. The human gene for renin-binding protein. (PMID: 1618798) Takahashi S. … Miyake Y. (J. Biol. Chem. 1992) 2 3 23
  4. The central cavity from the (alpha/alpha)6 barrel structure of Anabaena sp. CH1 N-acetyl-D-glucosamine 2-epimerase contains two key histidine residues for reversible conversion. (PMID: 17292397) Lee Y.C. … Hsu W.H. (J. Mol. Biol. 2007) 25 26
  5. Production of N-acetyl-D-neuraminic acid by recombinant whole cells expressing Anabaena sp. CH1 N-acetyl-D-glucosamine 2-epimerase and Escherichia coli N-acetyl-D-neuraminic acid lyase. (PMID: 17349707) Lee Y.C. … Hsu W.H. (J. Biotechnol. 2007) 25 26

Products for RENBP Gene

Sources for RENBP Gene

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