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REN Gene

protein-coding   GIFtS: 69
GCID: GC01M204123

Renin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
renin1 2     angiotensinogenase2
EC 3.4.23.153 8     Renin Precursor, Renal2
HNFJ22 5     Angiotensinogenase3
Angiotensin-Forming Enzyme2     EC 3.4.238

External Ids:    HGNC: 99581   Entrez Gene: 59722   Ensembl: ENSG000001438397   OMIM: 1798205   UniProtKB: P007973   

Export aliases for REN gene to outside databases

Previous GC identifers: GC01M201847 GC01M199584 GC01M200484 GC01M201301 GC01M200855 GC01M202390 GC01M175289


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for REN Gene:
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in
aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves
angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme,
an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different
protein isoforms and that arise from alternative splicing and the use of alternative promoters have been
described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause
familial hyperproreninemia. (provided by RefSeq, Jul 2008)

GeneCards Summary for REN Gene:
REN (renin) is a protein-coding gene. Diseases associated with REN include fibromuscular dysplasia, and renal artery obstruction. GO annotations related to this gene include aspartic-type endopeptidase activity and receptor binding. An important paralog of this gene is PGA5.

UniProtKB/Swiss-Prot: RENI_HUMAN, P00797
Function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from
angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and
increased sodium retention by the kidney

Gene Wiki entry for REN (Renin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the REN gene promoter:
         c-Fos   CREB   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREN promoter sequence
   Search Chromatin IP Primers for REN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

REN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M204123:  view genomic region     (about GC identifiers)

Start:
204,123,944 bp from pter      End:
204,135,465 bp from pter
Size:
11,522 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RENI_HUMAN, P00797 (See protein sequence)
Recommended Name: Renin precursor  
Size: 406 amino acids; 45057 Da
Subunit: Interacts with ATP6AP2
Selected PDB 3D structures from and Proteopedia for REN (see all 66):
1BBS (3D)        1BIL (3D)        1BIM (3D)        1HRN (3D)        1RNE (3D)        2BKS (3D)    
Secondary accessions: Q6FI38 Q6T5C2
Alternative splicing: 2 isoforms:  P00797-1   P00797-2   

Explore the universe of human proteins at neXtProt for REN: NX_P00797

Explore proteomics data for REN at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn71, Asn141
  • Selected DME Specific Peptides for REN (P00797) (see all 17)
     VLGGSDP  VVFDTGS  NNRIGFA  DIPPPTGP 


    See REN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000528.1  
    ENSEMBL proteins: 
     ENSP00000272190   ENSP00000356163  
    Reactome Protein details: P00797

    REN Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for REN
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    Cloud-Clone Corp. Proteins for REN

    REN Antibody Products:

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    REN Assay Products:

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    Cloud-Clone Corp. ELISAs for REN
    Cloud-Clone Corp. CLIAs for REN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR021109 Peptidase_aspartic_dom
     IPR001969 Aspartic_peptidase_AS
     IPR012848 Aspartic_peptidase_N
     IPR001461 Aspartic_peptidase

    Graphical View of Domain Structure for InterPro Entry P00797

    ProtoNet protein and cluster: P00797

    1 Blocks protein domain: IPB001461 Pepsin (A1) aspartic protease family signature

    UniProtKB/Swiss-Prot: RENI_HUMAN, P00797
    Similarity: Belongs to the peptidase A1 family


    REN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RENI_HUMAN, P00797
    Function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from
    angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and
    increased sodium retention by the kidney
    Catalytic activity: Cleavage of Leu- -Xaa bond in angiotensinogen to generate angiotensin I
    Enzyme regulation: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing
    Biophysicochemical properties: Kinetic parameters: KM=1 uM for angiotensinogen (in absence of ATP6AP2); KM=0.15 uM
    for angiotensinogen (in presence of membrane-bound ATP6AP2);

         Genatlas biochemistry entry for REN:
    renin,40kDa,angiotensin-forming enzyme

         Enzyme Numbers (IUBMB): EC 3.4.23.151 2 EC 3.4.232

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity ----
    GO:0004190aspartic-type endopeptidase activity IDA12045255
    GO:0005102receptor binding IPI12045255
    GO:0005159insulin-like growth factor receptor binding IEA--
    GO:0008233peptidase activity IDA12045255
         
    REN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for REN:
     Increased number of cells in m 

         12 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Ren1):
     behavior/neurological  cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle  nervous system  normal 
     renal/urinary system  reproductive system 

    REN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for REN: Ren1tm1Tkh Ren1tm1Bjm Ren1tm3Gom Ren1tm1Mgfs

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for REN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for REN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REN

    miRNA
    Products:
        
    miRTarBase miRNAs that target REN:
    hsa-mir-335-5p (MIRT017611)

    Block miRNA regulation of human, mouse, rat REN using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate REN:
    hsa-miR-1264 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidREN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for REN
    Predesigned siRNA for gene silencing in human, mouse, rat REN

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: REN (NM_000537)
    Sino Biological Human cDNA Clone for REN
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REN

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RENI_HUMAN, P00797: Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    lysosome3
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    golgi apparatus2
    mitochondrion2
    nucleus2
    peroxisome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA12045255
    GO:0005622intracellular IEA--
    GO:0005886plasma membrane TAS--

    REN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for REN About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.37
    ACE Inhibitor Pathway, Pharmacodynamics0.00
    Renin-angiotensin system0.37
    ACE Inhibitor Pathway0.00
    2Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Metabolism of Angiotensinogen to Angiotensins0.00
    3p70S6K Signaling
    Renin-Angiotensin Pathway0.60
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for REN
        Renin-Angiotensin Pathway

    2 Cell Signaling Technology (CST) Pathways for REN
        Angiogenesis
    Protein Stability

    1 BioSystems Pathway for REN
        ACE Inhibitor Pathway


    1 Reactome Pathway for REN
        Metabolism of Angiotensinogen to Angiotensins

    2 PharmGKB Pathways for REN
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for REN):
        Renin-angiotensin system


    REN for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including REN: 
              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for REN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for REN (P007972, 3 ENSP000002721904) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCTD15Q96SI12, 3, ENSP000003943904MINT-65369 I2D: score=5 STRING: ENSP00000394390
    ATP6AP2O757873, ENSP000003676974I2D: score=2 STRING: ENSP00000367697
    M6PRP206453, ENSP000000004124I2D: score=1 STRING: ENSP00000000412
    PCSK1P291203, ENSP000003080244I2D: score=1 STRING: ENSP00000308024
    PCSK5Q928243, ENSP000003659434I2D: score=1 STRING: ENSP00000365943
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development IMP16116425
    GO:0001823mesonephros development IEA--
    GO:0002003angiotensin maturation TAS--
    GO:0002016regulation of blood volume by renin-angiotensin ----
    GO:0002018renin-angiotensin regulation of aldosterone production IEA--

    REN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for REN
      Browse compounds at ApexBio 

    Browse Tocris compounds for REN (RENI)

    1 HMDB Compound for REN    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    Selected DrugBank Compounds for REN (see all 18)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AliskirenRasilez (see all 2)173334-57-1targetinhibitor11799102 16467656 16965731 16508564 11752352 12927775
    Remikiren-- 126222-34-2targetinhibitor8206619 7769797 11752352 7994817 8319997 10583449
    1-Hydroxy-2-Amino-3-Cyclohexylpropane-- --target--17139284 17016423 10592235
    1-Hydroxy-3-Methylbutane-- --target--17139284 17016423 10592235
    1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine-- --target--17139284 17016423 10592235
    2-Cyclopropylmethylenepropanal-- --target--17139284 17016423 10592235
    3-Phenyl-1,2-Propandiol-- --target--17139284 17016423 10592235
    Dimethylformamide-- 68-12-2target--17139284 17016423 10592235
    (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE-- --target--10592235
    2-Methyl-3-(2-Aminothiazolo)Propanal-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for REN gene (see all 145)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aliskiren 96.6 412 18981317 (6), 18388329 (5), 12927775 (4), 17318797 (4) (see all 99)
    remikiren 88.9 40 8498974 (4), 8064166 (3), 8730920 (2), 8491068 (2) (see all 20)
    enalkiren 86.1 20 2190927 (2), 2013477 (2), 1705633 (2), 8319997 (2) (see all 12)
    sodium 84.7 443 9369279 (7), 8567042 (3), 8411837 (3), 10677399 (3) (see all 99)
    captopril 80.1 155 8021469 (5), 1663967 (3), 7910062 (3), 8834702 (3) (see all 99)
    norepinephrine 78 382 18087164 (6), 2406102 (4), 8420299 (3), 16174881 (3) (see all 99)
    tetrahydroaldosterone 77.1 2 12850384 (1), 8639013 (1)
    fludrocortisone 75.2 11 14597859 (2), 11244008 (2), 10469007 (1), 15179565 (1) (see all 9)
    aldosterone 18-glucuronide 72.8 3 12850384 (2), 8639013 (1)
    spironolactone 72.6 32 17490489 (4), 10594479 (4), 9075669 (3), 15745200 (2) (see all 16)

    1 PharmGKB related drug/compound annotation for REN gene    About this table
    Drug/compound PharmGKB Annotation
    muraglitazarCA  



    REN for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for REN gene: 
    NM_000537.3  

    Unigene Cluster for REN:

    Renin
    Hs.3210  [show with all ESTs]
    Unigene Representative Sequence: NM_000537
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272190 ENST00000367195(uc001haq.2)

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    2 qRT-PCR Assays for microRNAs that regulate REN:
    hsa-miR-1264 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidREN 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REN
      QuantiTect SYBR Green Assays in human, mouse, rat REN
      QuantiFast Probe-based Assays in human, mouse, rat REN

    Additional mRNA sequence: 

    AF117822.1 BC033474.1 BC047752.1 CR536498.1 X00063.1 

    2 DOTS entries:

    DT.411947  DT.121384325 

    Selected AceView cDNA sequences (see all 47):

    BX108221 CB044030 BC047752 CB044992 BM543760 CB853064 AW771349 AW513938 
    CB044005 CB044002 AW445055 BI759718 BC033474 CR536498 CB044993 CB045004 
    CB045283 NM_000537 AW513649 AI480334 BM906275 BI761258 BI517900 N27400 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    REN expression in normal human tissues (normalized intensities)      REN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    REN Expression
    About this image


    REN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
             Testis Interstitium
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
    REN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.3210
        Pathway & Disease-focused RT2 Profiler PCR Array including REN: 
              Hypertension in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat REN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for REN gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ren11 , 5 renin 1 structural1, 5 77.47(n)1
    70.6(a)1
      1 (57.91 cM)5
    197011  NM_031192.31  NP_112469.11 
     1333505105 
    chicken
    (Gallus gallus)
    Aves REN1 renin 65.32(n)
    56.72(a)
      431167  XM_003642739.2  XP_003642787.2 
    lizard
    (Anolis carolinensis)
    Reptilia REN6
    renin
    52(a)
    1 ↔ 1
    4(117848168-117862471)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ren1 renin 60.79(n)
    56.37(a)
      100487524  XM_002940362.2  XP_002940408.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ren1 renin 58.95(n)
    53.46(a)
      405786  NM_212860.1  NP_998025.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG101041 , 3 cathepsin D3
    CG101041
    39(a)
    (best of 3)3
    49.55(n)1
    40.81(a)1
      51A13
    366021  NM_137117.11  NP_610961.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C11D2.23 protease 32(a)
    (best of 4)
      IV(6185340-6189393)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PEP46
    Vacuolar aspartyl protease (proteinase A), require...
    33(a)
    1 → many
    XVI(259714-260931) YPL154C


    ENSEMBL Gene Tree for REN (if available)
    TreeFam Gene Tree for REN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for REN gene
    PGA52  BACE12  CTSD2  PGA32  BACE22  NAPSA2  PGA42  CTSE2  
    PGC2  
    7 SIMAP similar genes for REN using alignment to 1 protein entry:     RENI_HUMAN:
    CTSD    CTSE    PGA3    NAPSA    PGC    PGA4
    PGA5

    REN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for REN (see all 391)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0637704
    Familial juvenile hyperuricemic nephropathy 2 (HNFJ2)4--see VAR_0637702 L R mis40--------
    VAR_0350884
    Renal tubular dysgenesis (RTD)4--see VAR_0350882 D N mis40--------
    VAR_0350874
    Renal tubular dysgenesis (RTD)4--see VAR_0350872 R K mis40--------
    rs1219177411,2
    Cpathogenic1210668972(-) AGGAAC/TGAGGT 2 R * stg11Minor allele frequency- T:0.00EU 1323
    rs1407712101,2
    Cuntested1210663640(+) CCAGCA/GATTGG 2 S L mis10--------
    rs604053761,2
    C--204127227(+) CCCCC-/CACGCC 1 -- int10--------
    rs115711121,2
    C,F--204130225(-) AAAAAC/AAAAAA 1 -- int14Minor allele frequency- A:0.02NS NA 234
    rs115711271,2
    C--210661188(-) CTTTAC/TAGGTG 1 -- int13Minor allele frequency- T:0.01NS 236
    rs115711261,2
    C,F--210661370(-) CTGAGT/CTCAGA 1 -- int17Minor allele frequency- C:0.02NS WA EA 658
    rs115710931,2
    C,F,H--210661398(-) AAGTTC/GTCCCA 1 -- int133Minor allele frequency- G:0.08NS EA NA 4094

    HapMap Linkage Disequilibrium report for REN (204123944 - 204135465 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for REN: --
    Human Gene Mutation Database (HGMD): REN
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing REN
    DNA2.0 Custom Variant and Variant Library Synthesis for REN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179820   
    OMIM disorders: 267430  613092  
    UniProtKB/Swiss-Prot: RENI_HUMAN, P00797
  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular
    development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia
    from early-onset oligohydramnios (the Potter phenotype). Note=The disease is caused by mutations affecting the
    gene represented in this entry
  • Familial juvenile hyperuricemic nephropathy 2 (HNFJ2) [MIM:613092]: A renal disease characterized by
    juvenile onset of hyperuricemia, slowly progressive renal failure and anemia. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for REN (see all 188):    About MalaCards
    fibromuscular dysplasia    renal artery obstruction    familial juvenile hyperuricemic nephropathy type 2    chronic intestinal failure
    renovascular hypertension    ren-related kidney disease    hyporeninemic hypoaldosteronism    renal tubular dysgenesis, ren-related
    autoimmune polyendocrinopathy type 2    hepatorenal syndrome    low renin hypertension    renal tubular dysgenesis
    hypoaldosteronism    chronic angina    17-alpha-hydroxylase deficiency    renal hypertension
    familial juvenile hyperuricemic nephropathy    malignant hypertension    pure autonomic failure    bartter syndrome, type 2

    16 diseases from the University of Copenhagen DISEASES database for REN:
    Hypertension     Conn's syndrome     Kidney disease     Hyperaldosteronism
    Hypokalemia     Congestive heart failure     Cerebrovascular accident     Adenoma
    Liver cirrhosis     Diabetes mellitus     Myocardial infarction     Cushing's syndrome
    Metabolic acidosis     Adrenoleukodystrophy     Portal hypertension     Addison's disease

    REN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for REN gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aldosteronism primary 90.8 139 12406976 (5), 9522976 (4), 8873937 (3), 10999820 (3) (see all 93)
    hyperaldosteronism 87.4 29 1644014 (3), 18260994 (2), 16172426 (1), 1471937 (1) (see all 26)
    essential hypertension 87 174 8076423 (3), 9488241 (3), 7910062 (3), 7606651 (3) (see all 99)
    renin hypertension 85.7 10 9091855 (1), 9039138 (1), 7662248 (1), 2194031 (1) (see all 10)
    hypertension renovascular 82.1 64 1962648 (4), 11022891 (3), 7731487 (2), 1763831 (2) (see all 45)
    low renin hypertension 80.2 9 11587161 (2), 7883826 (1), 17015767 (1), 11903321 (1) (see all 7)
    hypokalemia 79.7 55 12611241 (2), 8255271 (2), 8155305 (1), 7651282 (1) (see all 51)
    renal artery stenosis 78.4 48 9488241 (5), 11078179 (2), 2081013 (2), 16814133 (2) (see all 36)
    hypoaldosteronism 75.6 10 11423756 (2), 20154436 (2), 8324299 (1), 7808093 (1) (see all 6)
    glucocorticoid-remediable aldosteronism 75.4 1 8396580 (1)

    Genetic Association Database (GAD): REN
    Human Genome Epidemiology (HuGE) Navigator: REN (241 documents)

    Export disorders for REN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for REN gene, integrated from 10 sources (see all 2327):
    (articles sorted by number of sources associating them with REN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. [Contribution of CYP11B2, REN and AGT genes in genetic predisposition to arterial hypertension associated with hyperaldosteronism]. (PubMed id 18260994)1, 4, 9 Chikhladze N.M....Favorova O.O. (Kardiologiia 2008)
    2. Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure. (PubMed id 19664745)1, 2, 9 Zivna M.... Kmoch S. (Am. J. Hum. Genet. 2009)
    3. [Comparative genetic analysis of different forms of low-renin arterial hypertension]. (PubMed id 18856058)1, 4, 9 Chikhladze N.M....Favorova O.O. (Mol. Biol. (Mosk.) 2008)
    4. Associations between hypertension and genes in the renin-angiotensin system. (PubMed id 12695419)1, 4, 9 Zhu X....Chakravarti A. (Hypertension 2003)
    5. Haplotypes of the human renin gene associated with essential hypertension and stroke. (PubMed id 11224002)1, 4, 9 Frossard P.M....Kane J.P. (J Hum Hypertens 2001)
    6. Relationship between the renin-angiotensin system genes and diabetic nephropathy in the Chinese. (PubMed id 11776100)1, 4, 9 Wu S....Li J. (Chin. Med. J. 2000)
    7. Analysis of renin-angiotensin aldosterone system gene polymorphisms in Malaysian essential hypertensive and type 2 diabetic subjects. (PubMed id 19243623)1, 4, 9 Ramachandran V....Shamsudin N. (Cardiovasc Diabetol 2009)
    8. Association of renin-angiotensin system and natriuretic peptide receptor A gene polymorphisms with hypertension in a Hellenic population. (PubMed id 19126660)1, 4, 9 Tsezou A....Triposkiadis F. (J Renin Angiotensin Aldosterone Syst 2008)
    9. Combined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon region. (PubMed id 17546276)1, 4, 9 Freitas S.R....BA^ia M.N. (Arq. Bras. Cardiol. 2007)
    10. Renin gene polymorphisms and haplotypes, blood pressure, and responses to renin-angiotensin system inhibition. (PubMed id 17562974)1, 4, 9 Moore N....Stanton A.V. (Hypertension 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5972 HGNC: 9958 AceView: REN Ensembl:ENSG00000143839 euGenes: HUgn5972
    ECgene: REN Kegg: 5972 H-InvDB: REN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for REN Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Renin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for REN gene:
    Search GeneIP for patents involving REN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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