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Aliases for REN Gene

Aliases for REN Gene

  • Renin 2 3
  • Angiotensinogenase 3 4
  • EC 4 63
  • HNFJ2 3 6
  • Angiotensin-Forming Enzyme 3
  • Renin Precursor, Renal 3
  • EC 3.4.23 63

External Ids for REN Gene

Previous GeneCards Identifiers for REN Gene

  • GC01M201847
  • GC01M199584
  • GC01M200484
  • GC01M201301
  • GC01M200855
  • GC01M202390
  • GC01M175289

Summaries for REN Gene

Entrez Gene Summary for REN Gene

  • Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for REN Gene

REN (Renin) is a Protein Coding gene. Diseases associated with REN include hyperuricemic nephropathy, familial juvenile 2 and renal tubular dysgenesis, ren-related. Among its related pathways are p70S6K Signaling and Angiogenesis (CST). GO annotations related to this gene include receptor binding and aspartic-type endopeptidase activity. An important paralog of this gene is BACE1.

UniProtKB/Swiss-Prot for REN Gene

  • Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney

Gene Wiki entry for REN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REN Gene

Genomics for REN Gene

Regulatory Elements for REN Gene

Genomic Location for REN Gene

204,154,816 bp from pter
204,166,337 bp from pter
11,522 bases
Minus strand

Genomic View for REN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REN Gene

Proteins for REN Gene

  • Protein details for REN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6FI38
    • Q6T5C2

    Protein attributes for REN Gene

    406 amino acids
    Molecular mass:
    45057 Da
    Quaternary structure:
    • Interacts with ATP6AP2.

    Three dimensional structures from OCA and Proteopedia for REN Gene

    Alternative splice isoforms for REN Gene


neXtProt entry for REN Gene

Proteomics data for REN Gene at MOPED

Post-translational modifications for REN Gene

  • Glycosylation at Asn71 and Asn141
  • Modification sites at PhosphoSitePlus

Other Protein References for REN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for REN (REN)

Protein Products

Domains for REN Gene

Suggested Antigen Peptide Sequences for REN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P00797
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with REN: view

No data available for Gene Families for REN Gene

Function for REN Gene

Molecular function for REN Gene

GENATLAS Biochemistry: renin,40kDa,angiotensin-forming enzyme
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1 uM for angiotensinogen (in absence of ATP6AP2); KM=0.15 uM for angiotensinogen (in presence of membrane-bound ATP6AP2);
UniProtKB/Swiss-Prot CatalyticActivity: Cleavage of Leu- -Xaa bond in angiotensinogen to generate angiotensin I
UniProtKB/Swiss-Prot EnzymeRegulation: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing
UniProtKB/Swiss-Prot Function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney

Enzyme Numbers (IUBMB) for REN Gene

Gene Ontology (GO) - Molecular Function for REN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity --
GO:0004190 aspartic-type endopeptidase activity IDA 12045255
GO:0005102 receptor binding IPI 12045255
GO:0005159 insulin-like growth factor receptor binding IEA --
GO:0008233 peptidase activity IDA 12045255
genes like me logo Genes that share ontologies with REN: view
genes like me logo Genes that share phenotypes with REN: view

Animal Models for REN Gene

MGI Knock Outs for REN:

Animal Model Products

CRISPR Products

miRNA for REN Gene

miRTarBase miRNAs that target REN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REN

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for REN Gene

Localization for REN Gene

Subcellular locations from UniProtKB/Swiss-Prot for REN Gene

Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.

Subcellular locations from

Jensen Localization Image for REN Gene COMPARTMENTS Subcellular localization image for REN gene
Compartment Confidence
extracellular 5
plasma membrane 4
lysosome 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
nucleus 2
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for REN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 12045255
GO:0005622 intracellular --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with REN: view

Pathways for REN Gene

genes like me logo Genes that share pathways with REN: view

Pathways by source for REN Gene

1 Qiagen pathway for REN Gene
2 Cell Signaling Technology pathways for REN Gene
1 BioSystems pathway for REN Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for REN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IMP 16116425
GO:0001823 mesonephros development IEA --
GO:0002003 angiotensin maturation TAS --
GO:0002016 regulation of blood volume by renin-angiotensin --
GO:0002018 renin-angiotensin regulation of aldosterone production IEA --
genes like me logo Genes that share ontologies with REN: view

Compounds for REN Gene

(1) HMDB Compounds for REN Gene

Compound Synonyms Cas Number PubMed IDs
  • Sodium

(145) Novoseek inferred chemical compound relationships for REN Gene

Compound -log(P) Hits PubMed IDs
aliskiren 96.6 213
remikiren 88.9 33
enalkiren 86.1 18
sodium 84.7 160
captopril 80.1 120

(1) PharmGKB related drug/compound annotations for REN Gene

Drug/compound Annotation
muraglitazar CA
genes like me logo Genes that share compounds with REN: view

Transcripts for REN Gene

mRNA/cDNA for REN Gene

(47) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for REN Gene

Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REN Gene

No ASD Table

Relevant External Links for REN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REN Gene

mRNA expression in normal human tissues for REN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REN Gene

This gene is overexpressed in Kidney - Cortex (43.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for REN Gene

SOURCE GeneReport for Unigene cluster for REN Gene Hs.3210

genes like me logo Genes that share expressions with REN: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for REN Gene

Orthologs for REN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia REN 35
  • 99.51 (n)
  • 100 (a)
REN 36
  • 100 (a)
(Bos Taurus)
Mammalia REN 35
  • 80.1 (n)
  • 74.56 (a)
REN 36
  • 74 (a)
(Canis familiaris)
Mammalia REN 35
  • 81.16 (n)
  • 72.86 (a)
REN 36
  • 72 (a)
(Mus musculus)
Mammalia Ren1 35
  • 77.47 (n)
  • 70.6 (a)
Ren1 16
Ren1 36
  • 70 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
-- 36
  • 50 (a)
-- 36
  • 54 (a)
-- 36
  • 57 (a)
-- 36
  • 52 (a)
-- 36
  • 42 (a)
-- 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia REN 36
  • 52 (a)
(Rattus norvegicus)
Mammalia Ren 35
  • 76.17 (n)
  • 67 (a)
(Gallus gallus)
Aves REN 35
  • 65.32 (n)
  • 56.72 (a)
REN 36
  • 51 (a)
(Anolis carolinensis)
Reptilia REN 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ren 35
  • 60.79 (n)
  • 56.37 (a)
(Danio rerio)
Actinopterygii ren 35
  • 58.95 (n)
  • 53.46 (a)
ren 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10104 35
  • 49.55 (n)
  • 40.81 (a)
CG5860 37
  • 36 (a)
pcl 37
  • 35 (a)
CG10104 37
  • 39 (a)
(Caenorhabditis elegans)
Secernentea asp-3 36
  • 33 (a)
C11D2.2 37
  • 32 (a)
F28A12.4 37
  • 26 (a)
F59D6.2 37
  • 29 (a)
asp-2 37
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP4 36
  • 33 (a)
Species with no ortholog for REN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REN Gene

Gene Tree for REN (if available)
Gene Tree for REN (if available)

Paralogs for REN Gene

Paralogs for REN Gene

Selected SIMAP similar genes for REN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with REN: view

Variants for REN Gene

Sequence variations from dbSNP and Humsavar for REN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs5704 -- 204,166,285(-) GATGG(A/T)TGGAG reference, synonymous-codon
rs5705 -- 204,162,058(-) CTGAC(A/C)CTTGG reference, synonymous-codon
rs5706 -- 204,160,557(-) ACCGT(A/G)AGTTG intron-variant
rs5707 -- 204,160,543(-) CGCCC(G/T)AGGTC intron-variant
rs5708 -- 204,155,810(-) GGTTC(A/G)AGTCG intron-variant

Relevant External Links for REN Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for REN Gene

Disorders for REN Gene

(2) OMIM Diseases for REN Gene (179820)


  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269 PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Familial juvenile hyperuricemic nephropathy 2 (HNFJ2) [MIM:613092]: A renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia. {ECO:0000269 PubMed:19664745}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(97) Novoseek inferred disease relationships for REN Gene

Disease -log(P) Hits PubMed IDs
aldosteronism primary 90.8 123
hyperaldosteronism 87.4 29
essential hypertension 87 130
renin hypertension 85.7 10
hypertension renovascular 82.1 59

Relevant External Links for REN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with REN: view

Publications for REN Gene

  1. Haplotypes of the human renin gene associated with essential hypertension and stroke. (PMID: 11224002) Frossard P.M. … Kane J.P. (J Hum Hypertens 2001) 3 23 48
  2. Strong association of a renin intronic dimorphism with essential hypertension. (PMID: 16138564) Ahmad U. … Frossard P.M. (Hypertens. Res. 2005) 3 23 48
  3. Renin gene polymorphisms and haplotypes, blood pressure, and responses to renin-angiotensin system inhibition. (PMID: 17562974) Moore N. … Stanton A.V. (Hypertension 2007) 3 23 48
  4. [Contribution of CYP11B2, REN and AGT genes in genetic predisposition to arterial hypertension associated with hyperaldosteronism]. (PMID: 18260994) Chikhladze N.M. … Favorova O.O. (Kardiologiia 2008) 3 23 48
  5. [Comparative genetic analysis of different forms of low-renin arterial hypertension]. (PMID: 18856058) Chikhladze N.M. … Favorova O.O. (Mol. Biol. (Mosk.) 2008) 3 23 48

Products for REN Gene

Sources for REN Gene

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