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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

REN Gene

protein-coding GIFtS: 68
GCID: GC01M204123

renin

Explore 205 diseases affiliated with
REN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Renin¹		Angiotensinogenase³
EC 3.4.23.15³ ⁸		Renin Precursor, Renal²
HNFJ2² ⁵		Angiotensinogenase³
Angiotensin-Forming Enzyme²		EC 3.4.23⁸

External Ids:	HGNC: 9958¹	Entrez Gene: 5972²	Ensembl: ENSG00000143839⁷	OMIM: 179820⁵	UniProtKB: P00797³

Export aliases for REN gene to outside databases

Previous GC identifers: GC01M201847 GC01M199584 GC01M200484 GC01M201301 GC01M200855 GC01M202390 GC01M175289

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for REN:

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone

release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form

angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of

blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from

alternative splicing and the use of alternative promoters have been described, but their full-length nature has not

been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: RENI_HUMAN, P00797

Function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from

angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and

increased sodium retention by the kidney

Gene Wiki entry for REN (Renin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the REN gene promoter:
c-Fos CREB AP-1 deltaCREB ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: REN promoter sequence

Search SABiosciences Chromatin IP Primers for REN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32

REN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REN gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M204123: view genomic region (about GC identifiers)

Start:	204,123,944 bp from pter	End:	204,135,465 bp from pter
Size:	11,522 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RENI_HUMAN, P00797 (See protein sequence)

Recommended Name: Renin precursor

Size: 406 amino acids; 45057 Da

Subunit: Interacts with ATP6AP2

Subcellular location: Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2

6/61 PDB 3D structures from and Proteopedia for REN (see all 61):

1BBS (3D)

1BIL (3D)

1BIM (3D)

1HRN (3D)

1RNE (3D)

2BKS (3D)

Secondary accessions: Q6FI38 Q6T5C2

Alternative splicing: 2 isoforms: P00797-1 P00797-2

Explore the universe of human proteins at neXtProt for REN: NX_P00797

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P00797

4/17 DME Specific Peptides for REN (P00797) (see all 17)

VLGGSDP

VVFDTGS

NNRIGFA

DIPPPTGP

REN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000528.1

ENSEMBL proteins:

ENSP00000272190 ENSP00000356163

Reactome Protein details: P00797
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for REN (Renin)
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	GenScript Custom Purified and Recombinant Proteins Services for REN
	Novus Biologicals REN Protein Novus Biologicals REN Lysate
	Sino Biological Recombinant Protein for REN
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for REN

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	12045255
GO:0005622	intracellular	--	--
GO:0016020	membrane	IEA	--
GO:0044444	cytoplasmic part	IEA	--

REN for ontologies About GeneDecksing

REN Antibody Products:

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	R&D Systems Antibodies for REN (Renin)
	Cell Signaling Technology (CST) Antibodies for REN
	OriGene Antibodies (see all 2): REN OriGene Custom Antibody Services for REN
	GenScript Custom Superior Antibodies Services for REN
	Novus Biologicals REN Antibodies
	Abcam antibodies for REN
	Uscn Antibodies for REN
	ThermoFisher Antibody for REN

Assay Products for REN:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for REN (Renin) (see all)
	GenScript Custom Assay Services for REN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for REN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

REN for domains About GeneDecksing

4 InterPro domains/families:

IPR021109 Peptidase_aspartic

IPR001969 Peptidase_aspartic_AS

IPR012848 Propep_A1

IPR001461 Peptidase_A1

Graphical View of Domain Structure for InterPro Entry P00797

ProtoNet protein and cluster: P00797

1 Blocks protein family: IPB001461 Pepsin (A1) aspartic protease family signature

UniProtKB/Swiss-Prot: RENI_HUMAN, P00797

Similarity: Belongs to the peptidase A1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RENI_HUMAN, P00797

Function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from

angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and

increased sodium retention by the kidney

Catalytic activity: Cleavage of Leu- -Xaa bond in angiotensinogen to generate angiotensin I

Enzyme regulation: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing

Biophysicochemical properties: Kinetic parameters: KM=1 uM for angiotensinogen (in absence of ATP6AP2); KM=0.15 uM for

angiotensinogen (in presence of membrane-bound ATP6AP2);

Genatlas biochemistry entry for REN:

renin,40kDa,angiotensin-forming enzyme

Enzyme Numbers (IUBMB): EC 3.4.23.15¹ ² EC 3.4.23²

miRNA Products:		OriGene 3'-UTR Clone: REN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REN
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate REN:
		hsa-miR-1264 hsa-miR-330-3p
		SwitchGear 3'UTR luciferase reporter plasmid: REN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REN (see all 4) OriGene shRNA RFP: REN OriGene siRNA: REN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REN

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for REN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REN (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REN OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: REN (NM_000537)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for REN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for REN
		Search LifeMap BioReagents cell lines for REN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REN

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004175	endopeptidase activity	--	--
GO:0004190	aspartic-type endopeptidase activity	IDA	12045255
GO:0005102	receptor binding	IPI	12045255
GO:0005159	insulin-like growth factor receptor binding	IEA	--
GO:0008233	peptidase activity	IDA	12045255

REN for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for REN:

Increased number of cells in m

Animal Models:
Mouse knock-outs for REN: Ren1^tm1Tkh Ren1^tm1Bjm Ren1^tm3Gom Ren1^tm1Mgfs
12 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Ren1):

behavior/neurological	cardiovascular system	growth/size	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	muscle	nervous system	normal
renal/urinary system	reproductive system

REN for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

	ACE Inhibitor Pathway, Pharmacodynamics	1.00			ACE Inhibitor Pathway	0.85
	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics	1.00

Renin-angiotensin system

Renin-angiotensin system

1.00

Metabolism of Angiotensinogen to Angiotensins

0.48

Protein Stability

Protein Stability

1.00

Angiogenesis

Angiogenesis

1.00

Selected targets of CREB1

Selected targets of CREB1

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for REN

Selected targets of CREB1

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for REN

Renin-Angiotensin Pathway

2 Cell Signaling Technology (CST) Pathways for REN

	Angiogenesis
	Protein Stability

1 BioSystems Pathway for REN

ACE Inhibitor Pathway

3 Reactome Pathways for REN

	Metabolism of Angiotensinogen to Angiotensins
	Metabolism of proteins
	Peptide hormone metabolism

2 PharmGKB Pathways for REN

	ACE Inhibitor Pathway, Pharmacodynamics
	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for REN):

Renin-angiotensin system

REN for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for REN

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/10 Interacting proteins for REN (P00797^{2, 3} ENSP00000272190⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCTD15	Q96SI1²^,³, ENSP00000394390⁴	MINT-65369 I2D: score=5 STRING: ENSP00000394390
ATP6AP2	O75787³, ENSP00000367697⁴	I2D: score=2 STRING: ENSP00000367697
M6PR	P20645³, ENSP00000000412⁴	I2D: score=1 STRING: ENSP00000000412
PCSK1	P29120³, ENSP00000308024⁴	I2D: score=1 STRING: ENSP00000308024
PCSK5	Q92824³, ENSP00000365943⁴	I2D: score=1 STRING: ENSP00000365943

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001822	kidney development	IMP	16116425
GO:0001823	mesonephros development	IEA	--
GO:0002003	angiotensin maturation	IDA	12045255
GO:0002016	regulation of blood volume by renin-angiotensin	--	--
GO:0002018	renin-angiotensin regulation of aldosterone production	IEA	--

REN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

REN for compounds About GeneDecksing

EMD Millipore small molecules for REN:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for REN

Browse Tocris compounds for REN

1 HMDB Compound for REN About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

10/18 DrugBank Compounds for REN (see all 18) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Aliskiren	Rasilez (see all 2)	173334-57-1	target	inhibitor	11799102 16467656 16965731 16508564 11752352 12927775
Remikiren	--	126222-34-2	target	inhibitor	8206619 7769797 11752352 7994817 8319997 10583449
1-Hydroxy-2-Amino-3-Cyclohexylpropane	--	--	target	--	17139284 17016423 10592235
1-Hydroxy-3-Methylbutane	--	--	target	--	17139284 17016423 10592235
1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine	--	--	target	--	17139284 17016423 10592235
2-Cyclopropylmethylenepropanal	--	--	target	--	17139284 17016423 10592235
3-Phenyl-1,2-Propandiol	--	--	target	--	17139284 17016423 10592235
Dimethylformamide	--	68-12-2	target	--	17139284 17016423 10592235
(2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE	--	--	target	--	10592235
2-Methyl-3-(2-Aminothiazolo)Propanal	--	--	target	--	10592235

10/145 Novoseek chemical compound relationships for REN gene (see all 145) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
aliskiren	96.6	412	18981317 (6), 18388329 (5), 12927775 (4), 17318797 (4) (see all 99)
remikiren	88.9	40	8498974 (4), 8064166 (3), 8730920 (2), 8491068 (2) (see all 20)
enalkiren	86.1	20	2190927 (2), 2013477 (2), 1705633 (2), 8319997 (2) (see all 12)
sodium	84.7	443	9369279 (7), 8567042 (3), 8411837 (3), 10677399 (3) (see all 99)
captopril	80.1	155	8021469 (5), 1663967 (3), 7910062 (3), 8834702 (3) (see all 99)
norepinephrine	78	382	18087164 (6), 2406102 (4), 8420299 (3), 16174881 (3) (see all 99)
tetrahydroaldosterone	77.1	2	12850384 (1), 8639013 (1)
fludrocortisone	75.2	11	14597859 (2), 11244008 (2), 10469007 (1), 15179565 (1) (see all 9)
aldosterone 18-glucuronide	72.8	3	12850384 (2), 8639013 (1)
spironolactone	72.6	32	17490489 (4), 10594479 (4), 9075669 (3), 15745200 (2) (see all 16)

1 PharmGKB related drug/compound annotation for REN gene

Drug/compound	PharmGKB Annotation
muraglitazar	CA

About this table

Search CenterWatch for drugs/clinical trials and news about REN / RENI

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for REN gene:

NM_000537.3

Unigene Cluster for REN:

Renin

Hs.3210 [show with all ESTs]

Unigene Representative Sequence: NM_000537

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000272190 ENST00000367195(uc001haq.2)

miRNA Products:		OriGene 3'-UTR Clone: REN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REN
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate REN:
		hsa-miR-1264 hsa-miR-330-3p
		SwitchGear 3'UTR luciferase reporter plasmid: REN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REN (see all 4) OriGene shRNA RFP: REN OriGene siRNA: REN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REN (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REN OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: REN (NM_000537)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for REN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat REN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REN

Additional cDNA sequence:

AF117822.1 BC033474.1 BC047752.1 CR536498.1 X00063.1

2 DOTS entries:

DT.411947 DT.121384325

24/47 AceView cDNA sequences (see all 47):

AW771349 AW445055 BX108221 CB045004 CB044030 CB044993 BM543760 BI759718

BC047752 AW513938 CB044002 CR536498 CB044992 CB853064 BC033474 CB044005

AW513368 CB044006 AW513666 NM_000537 CB045283 BI517900 AW615180 AI480334

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

REN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

REN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Afferent Arteriole

Juxtaglomerular Cells

Selective marker (cell-identifying gene)

Kidney, Smooth Muscle

Brain

Neural Tube

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See REN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for REN

SOURCE GeneReport for Unigene cluster: Hs.3210

SABiosciences Expression via Pathway-Focused PCR Array including REN:

Hypertension in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat REN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for REN gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC431167¹	renin-like	64.37(n) 55.82(a)		431167 XM_003642739.1 XP_003642787.1
lizard (Anolis carolinensis)	Reptilia	REN⁶	--	52(a)	1 ↔ 1	4(117848426-117861183)
zebrafish (Danio rerio)	Actinopterygii	ren¹	renin	58.95(n) 53.46(a)		405786 NM_212860.1 NP_998025.1
fruit fly (Drosophila melanogaster)	Insecta	CG10104^{1 , 3}	cathepsin D³ CG10104¹	39(a) (best of 3)³ 49.55(n)¹ 40.81(a)¹		51A1³ 36602¹ NM_137117.1¹ NP_610961.1¹
worm (Caenorhabditis elegans)	Secernentea	C11D2.2³	protease	32(a) (best of 4)		IV(6185340-6189393) --

ENSEMBL Gene Tree for REN (if available)
TreeFam Gene Tree for REN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for REN gene

BACE1² CTSD² PGA3² BACE2² NAPSA² ENSG00000250644² CTSE² PGC²

PGA5² ENSG00000265969² PGA4²

7 SIMAP similar genes for REN using alignment to 1 protein entry: RENI_HUMAN:

CTSD CTSE NAPSA PGA3 PGC PGA4

PGA5

REN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121917741^1,2	C	pathogenic	204131245(-)	`AGGAAC/TGAGGT`	2	R *	stg¹		1		EU	1323
rs11571127^1,2	C	--	204123461(-)	`CTTTAC/TAGGTG`	1	--	int¹		3		NS	236
rs11571126^1,2	C,F,	--	204123643(-)	`CTGAGT/CTCAGA`	1	--	int¹		7		NS WA EA	658
rs11571093^1,2	C,F,H,	--	204123671(-)	`AAGTTC/GTCCCA`	1	--	int¹		33		NS EA NA	4094
rs188133694^1,2		--	204123731(+)	`TAGAGA/GGAGCT`	1	--	int¹		0	--	--	--	--
rs180937484^1,2		--	204123744(+)	`GTTCCG/TGCTCT`	1	--	int¹		0	--	--	--	--
rs11571125^1,2	C	--	204123830(-)	`CTTGCG/ATGCAG`	1	--	int¹		3		NS	236
rs147931655^1,2		--	204123844(+)	`CTGTGA/CGCTAG`	1	--	int¹		0	--	--	--	--
rs141188818^1,2		--	204123864(+)	`TAGCTC/TGTCTG`	1	--	int¹		0	--	--	--	--
rs11571124^1,2	C	--	204123999(-)	`CCCTGC/TACCAG`	1	--	ut3¹ ese³		5		NS NA	238

HapMap Linkage Disequilibrium report for REN (204123944 - 204135465 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for REN: --
Human Gene Mutation Database (HGMD): REN

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REN

DNA2.0 Custom Variant and Variant Library Synthesis for REN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

REN for disorders           About GeneDecksing

OMIM gene information: 179820
OMIM disorders: 267430  613092
UniProtKB/Swiss-Prot: RENI_HUMAN, P00797

Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive

severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably

due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype)

Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is

a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia

20/205 diseases for REN (see all 205): About MalaCards

hyperproreninemia 17-alpha-hydroxylase deficiency glucocorticoid-remediable aldosteronism 11-beta-hydroxylase deficiency

x-linked adrenal hypoplasia congenita aldosteronism apparent mineralocorticoid excess syndrome twin-to-twin transfusion syndrome

familial juvenile hyperuricemic nephropathy familial juvenile hyperuricemic nephropathy type 2 von hippel-lindau disease hyperuricemic nephropathy

pure autonomic failure twin twin transfusion syndrome 21-hydroxylase deficiency spinal cord injury

hyporeninemic hypoaldosteronism renal tubular dysgenesis chloride diarrhea high blood pressure

16 diseases from the University of Copenhagen DISEASES database for REN:

Hypertension Conn's syndrome Kidney disease Hyperaldosteronism

Hypokalemia Congestive heart failure Adenoma Cerebrovascular accident

Liver cirrhosis Diabetes mellitus Myocardial infarction Cushing's syndrome

Metabolic acidosis Portal hypertension Addison's disease Apparent mineralocorticoid excess syndrome

10/97 Novoseek disease relationships for REN gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
aldosteronism primary	90.8	139	12406976 (5), 9522976 (4), 8873937 (3), 10999820 (3) (see all 93)
hyperaldosteronism	87.4	29	1644014 (3), 18260994 (2), 16172426 (1), 1471937 (1) (see all 26)
essential hypertension	87	174	8076423 (3), 9488241 (3), 7910062 (3), 7606651 (3) (see all 99)
renin hypertension	85.7	10	9091855 (1), 9039138 (1), 7662248 (1), 2194031 (1) (see all 10)
hypertension renovascular	82.1	64	1962648 (4), 11022891 (3), 7731487 (2), 1763831 (2) (see all 45)
low renin hypertension	80.2	9	11587161 (2), 7883826 (1), 17015767 (1), 11903321 (1) (see all 7)
hypokalemia	79.7	55	12611241 (2), 8255271 (2), 8155305 (1), 7651282 (1) (see all 51)
renal artery stenosis	78.4	48	9488241 (5), 11078179 (2), 2081013 (2), 16814133 (2) (see all 36)
hypoaldosteronism	75.6	10	11423756 (2), 20154436 (2), 8324299 (1), 7808093 (1) (see all 6)
glucocorticoid-remediable aldosteronism	75.4	1	8396580 (1)

Genetic Association Database (GAD): REN
Human Genome Epidemiology (HuGE) Navigator: REN (241 documents)

Export disorders for REN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for REN gene, integrated from 9 sources (see all 2319):
(articles sorted by number of sources associating them with REN)

Utopia: connect your pdf to the dynamic
world of online information

Dominant renin gene mutations associated with early-o nset hyperuricemia, anemia, and chronic kidney failure. (PubMed id 19664745)^{1, 2, 9} ZivnA! M....Kmoch S. (2009)
Associations between hypertension and genes in the renin-angiotensin system. (PubMed id 12695419)^{1, 4, 9} Zhu X....Chakravarti A. (2003)
Haplotypes of the human renin gene associated with essential hypertension and stroke. (PubMed id 11224002)^{1, 4, 9} Frossard P.M....Kane J.P. (2001)
Relationship between the renin-angiotensin system genes and diabetic nephropathy in the Chinese. (PubMed id 11776100)^{1, 4, 9} Wu S....Li J. (2000)
Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. (PubMed id 16116425)^{1, 2, 9} Gribouval O.... Gubler M.-C. (2005)
Strong association of a renin intronic dimorphism with essential hypertension. (PubMed id 16138564)^{1, 4, 9} Ahmad U....Frossard P.M. (2005)
Genetic determinants of nonmodulating hypertension. (PubMed id 14530292)^{1, 4, 9} Kosachunhanun N....Williams G.H. (2003)
Angiotensin converting enzyme DD genotype is associated with hypertensive crisis. (PubMed id 12394950)^{1, 4, 9} Sunder-Plassmann G....Fodinger M. (2002)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Association study between the human Renin gene and preeclampsia. (PubMed id 16036389)^{1, 4} Maruyama A....Yamamoto T. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5972	HGNC: 9958	AceView: REN	Ensembl:ENSG00000143839	euGenes: HUgn5972
ECgene: REN	Kegg: 5972	H-InvDB: REN

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for REN	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Renin

Intellectual Property for REN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for REN gene:
Search GeneIP for patents involving REN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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renin

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Microalbuminuria
RENAL ARTERY OCCLUSION
Pseudohypoaldosteronism
essential hypertension
Hypoaldosteronism
DIASTOLIC HYPERTENSION
Potassium Serum Increased
Pure Autonomic Failure
RESPIRATORY DISTRESS SYNDROME IDIOPATHIC
Hypotension Orthostatic
GITELMAN SYNDROME
Fibromuscular Dysplasia
high renin hypertension
GLUCOCORTICOID-REMEDIABLE ALDOSTERONISM
Hypotension
mineralocorticoid hypertension
renin hypertension
HYPERPROSTAGLANDIN E SYNDROME
Renal Artery Stenosis
RENAL DISEASE
ADPKD
BRACHYDACTYLY
glomerulosclerosis
SYSTOLIC HYPERTENSION
Hypertension Malignant
Diabetic Nephropathies
Proteinuria
HYPOCHLOREMIA
adrenal hyperplasia
metabolic acidosis
Liddles syndrome
Adrenal Hyperplasia Congenital
Hypertrophy
Renal Failure
KIDNEY ATROPHIC
GORDON SYNDROME
AUTONOMIC NEUROPATHY
Cardiovascular Diseases
HYPOMAGNESEMIA
Liver Cirrhosis
Renal Failure Acute
Other endocrine disorders
Hypertension Renal
hypercalciuria
Preeclampsia
Cushing Syndrome
renal ischemia
Hypernatremia
renin-dependent hypertension
Tachycardia
Hyponatremia
Adenoma Adrenocortical
Cirrhosis
HYPERTENSION ARTERIAL
genetic hypertension
Hyperplasia
fluid overload
Aldosteronism Primary
RENOVASCULAR
metabolic alkalosis
RENAL TUBULAR DYSGENESIS
Multiple renal arteries
Addisons Disease
Hypoaldosteronism Hyporeninemic
Diabetes Mellitus
Heart Failure Congestive
low renin hypertension
Ventricular Dysfunction Left
Renal fibrosis
Endocrine Effects
systemic hypertension
renal scleroderma
Ovarian Hyperstimulation Syndrome
Effects Cardiovascular
Aldosteronism Secondary
BARTTER SYNDROME, CLASSIC
Hepatorenal Syndrome
Albuminuria
HEART FAILURE
Wilms tumor
Myocardial Infarction
Ascites
Adenoma
Secondary hypertension
Bartters syndrome
Hyperaldosteronism
Hypovolemia
Cardiac Hypertrophy
ventricular hypertrophy
ADRENAL TUMOR
STROKE
ADRENAL ADENOMA
Hypertension Renovascular
Hypokalemia
Hyperkalemia
HYPERCHLOREMIA
Renal Failure Chronic

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REN Gene

renin

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