Aliases for REN Gene
External Ids for REN Gene
Previous GeneCards Identifiers for REN Gene
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
GeneCards Summary for REN Gene
REN (Renin) is a Protein Coding gene. Diseases associated with REN include Hyperuricemic Nephropathy, Familial Juvenile, 2 and Renal Tubular Dysgenesis. Among its related pathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include receptor binding and endopeptidase activity. An important paralog of this gene is NAPSA.
UniProtKB/Swiss-Prot for REN Gene
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.