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Aliases for REN Gene

Aliases for REN Gene

  • Renin 2 3 5
  • Angiotensinogenase 3 4
  • EC 4 63
  • Angiotensin-Forming Enzyme 3
  • Renin Precursor, Renal 3
  • EC 3.4.23 63
  • HNFJ2 3

External Ids for REN Gene

Previous GeneCards Identifiers for REN Gene

  • GC01M201847
  • GC01M199584
  • GC01M200484
  • GC01M201301
  • GC01M200855
  • GC01M202390
  • GC01M175289

Summaries for REN Gene

Entrez Gene Summary for REN Gene

  • Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for REN Gene

REN (Renin) is a Protein Coding gene. Diseases associated with REN include Hyperuricemic Nephropathy, Familial Juvenile 2 and Renal Tubular Dysgenesis. Among its related pathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. GO annotations related to this gene include receptor binding and endopeptidase activity. An important paralog of this gene is BACE1.

UniProtKB/Swiss-Prot for REN Gene

  • Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Gene Wiki entry for REN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REN Gene

Genomics for REN Gene

Regulatory Elements for REN Gene

Enhancers for REN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around REN on UCSC Golden Path with GeneCards custom track

Genomic Location for REN Gene

204,154,816 bp from pter
204,166,337 bp from pter
11,522 bases
Minus strand

Genomic View for REN Gene

Genes around REN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REN Gene

Proteins for REN Gene

  • Protein details for REN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6FI38
    • Q6T5C2

    Protein attributes for REN Gene

    406 amino acids
    Molecular mass:
    45057 Da
    Quaternary structure:
    • Interacts with ATP6AP2.

    Three dimensional structures from OCA and Proteopedia for REN Gene

    Alternative splice isoforms for REN Gene


neXtProt entry for REN Gene

Proteomics data for REN Gene at MOPED

Post-translational modifications for REN Gene

  • Glycosylation at Asn 71 and Asn 141
  • Modification sites at PhosphoSitePlus

Other Protein References for REN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for REN (REN)

Domains & Families for REN Gene

Suggested Antigen Peptide Sequences for REN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase A1 domain.
  • Belongs to the peptidase A1 family.
  • Contains 1 peptidase A1 domain.
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with REN: view

No data available for Gene Families for REN Gene

Function for REN Gene

Molecular function for REN Gene

GENATLAS Biochemistry:
renin,40kDa,angiotensin-forming enzyme
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1 uM for angiotensinogen (in absence of ATP6AP2); KM=0.15 uM for angiotensinogen (in presence of membrane-bound ATP6AP2);
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of Leu- -Xaa bond in angiotensinogen to generate angiotensin I.
UniProtKB/Swiss-Prot EnzymeRegulation:
Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.
UniProtKB/Swiss-Prot Function:
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Enzyme Numbers (IUBMB) for REN Gene

Gene Ontology (GO) - Molecular Function for REN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005159 insulin-like growth factor receptor binding IEA --
genes like me logo Genes that share ontologies with REN: view
genes like me logo Genes that share phenotypes with REN: view

Human Phenotype Ontology for REN Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for REN Gene

MGI Knock Outs for REN:

Animal Model Products

miRNA for REN Gene

miRTarBase miRNAs that target REN

No data available for Transcription Factor Targets and HOMER Transcription for REN Gene

Localization for REN Gene

Subcellular locations from UniProtKB/Swiss-Prot for REN Gene

Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.

Subcellular locations from

Jensen Localization Image for REN Gene COMPARTMENTS Subcellular localization image for REN gene
Compartment Confidence
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
cytosol 3
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 2
nucleus 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for REN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with REN: view

Pathways & Interactions for REN Gene

genes like me logo Genes that share pathways with REN: view

Pathways by source for REN Gene

1 Cell Signaling Technology pathway for REN Gene
1 BioSystems pathway for REN Gene

SIGNOR curated interactions for REN Gene


Gene Ontology (GO) - Biological Process for REN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IMP 16116425
GO:0002016 regulation of blood volume by renin-angiotensin IEA --
GO:0002018 renin-angiotensin regulation of aldosterone production IEA --
GO:0006508 proteolysis IEA,IDA 12045255
GO:0010033 response to organic substance IEA --
genes like me logo Genes that share ontologies with REN: view

Drugs & Compounds for REN Gene

(119) Drugs for REN Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Remikiren Approved Pharma inhibitor, Target 0
Aliskiren Approved, Investigational Pharma inhibitor 0
Isopentanol Experimental Pharma Target 0
N,N-Dimethylformamide Experimental Pharma Target 0
NGD 94-1 Experimental Pharma Target, inhibitor 0

(50) Additional Compounds for REN Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
angiotensin I
Full agonist, Agonist

(3) ApexBio Compounds for REN Gene

Compound Action Cas Number
Acetyl Angiotensinogen (1-14), porcine Angiotensinogen precursor 66641-26-7
Aliskiren Hemifumarate 173334-58-2
Angiotensin III (human, mouse) Aldosterone stimulator 13602-53-4
genes like me logo Genes that share compounds with REN: view

Transcripts for REN Gene

mRNA/cDNA for REN Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for REN Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for REN Gene

No ASD Table

Relevant External Links for REN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REN Gene

mRNA expression in normal human tissues for REN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REN Gene

This gene is overexpressed in Kidney - Cortex (x43.6).

Protein differential expression in normal tissues from HIPED for REN Gene

This gene is overexpressed in Fetal ovary (45.5), Kidney (15.6), and Fetal testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for REN Gene

SOURCE GeneReport for Unigene cluster for REN Gene Hs.3210

genes like me logo Genes that share expression patterns with REN: view

Protein tissue co-expression partners for REN Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for REN Gene

Orthologs for REN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia REN 35
  • 80.1 (n)
  • 74.56 (a)
REN 36
  • 74 (a)
(Canis familiaris)
Mammalia REN 35
  • 81.16 (n)
  • 72.86 (a)
REN 36
  • 72 (a)
(Mus musculus)
Mammalia Ren1 35
  • 77.47 (n)
  • 70.6 (a)
Ren1 16
Ren1 36
  • 70 (a)
(Pan troglodytes)
Mammalia REN 35
  • 99.51 (n)
  • 100 (a)
REN 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ren 35
  • 76.17 (n)
  • 67 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
-- 36
  • 50 (a)
-- 36
  • 54 (a)
-- 36
  • 57 (a)
-- 36
  • 52 (a)
-- 36
  • 42 (a)
-- 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia REN 36
  • 52 (a)
(Gallus gallus)
Aves REN 35
  • 65.32 (n)
  • 56.72 (a)
REN 36
  • 51 (a)
(Anolis carolinensis)
Reptilia REN 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ren 35
  • 60.79 (n)
  • 56.37 (a)
(Danio rerio)
Actinopterygii ren 35
  • 58.95 (n)
  • 53.46 (a)
ren 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10104 37
  • 39 (a)
CG5860 37
  • 36 (a)
pcl 37
  • 35 (a)
CG10104 35
  • 49.55 (n)
  • 40.81 (a)
(Caenorhabditis elegans)
Secernentea asp-2 37
  • 31 (a)
C11D2.2 37
  • 32 (a)
F28A12.4 37
  • 26 (a)
F59D6.2 37
  • 29 (a)
asp-3 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP4 36
  • 33 (a)
Species with no ortholog for REN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REN Gene

Gene Tree for REN (if available)
Gene Tree for REN (if available)

Paralogs for REN Gene

Paralogs for REN Gene

(7) SIMAP similar genes for REN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with REN: view

Variants for REN Gene

Sequence variations from dbSNP and Humsavar for REN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11571098 - 204,166,197(-) TTAAA(C/T)GGTAA reference, missense
rs11571117 - 204,159,439(-) CCCAA(A/G)GGGTG reference, missense
rs11571083 - 204,160,574(-) TCAGC(A/C)AGGAC reference, missense
VAR_035087 Renal tubular dysgenesis (RTD)
VAR_035088 Renal tubular dysgenesis (RTD)

Variation tolerance for REN Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REN Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for REN Gene

Disorders for REN Gene

MalaCards: The human disease database

(116) MalaCards diseases for REN Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hyperuricemic nephropathy, familial juvenile 2
  • hnfj2
renal tubular dysgenesis
  • primitive renal tubule syndrome
hyperuricemia-anemia-renal failure syndrome
  • familial juvenile hyperuricemic nephropathy type 2
renal tubular dysgenesis of genetic origin
renal tubular dysgenesis, ren-related
  • ren-related primitive renal tubule syndrome
- elite association - COSMIC cancer census association via MalaCards
Search REN in MalaCards View complete list of genes associated with diseases


  • Familial juvenile hyperuricemic nephropathy 2 (HNFJ2) [MIM:613092]: A renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia. {ECO:0000269 PubMed:19664745}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269 PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for REN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with REN: view

No data available for Genatlas for REN Gene

Publications for REN Gene

  1. [Contribution of CYP11B2, REN and AGT genes in genetic predisposition to arterial hypertension associated with hyperaldosteronism]. (PMID: 18260994) Chikhladze N.M. … Favorova O.O. (Kardiologiia 2008) 3 48 67
  2. Responses to an orally active renin inhibitor, remikiren (Ro 42-5892), after controlled salt depletion in humans. (PMID: 7769797) MacFadyen R.J. … Reid J.L. (J. Cardiovasc. Pharmacol. 1995) 23 25 26
  3. Angiotensinergic versus nonangiotensinergic hemodynamic effects of converting enzyme inhibition in patients with chronic heart failure. Assessment by acute renin and converting enzyme inhibition. (PMID: 7994817) Kiowski W. … Meinertz T. (Circulation 1994) 23 25 26
  4. Vascular renin in the guinea pig. Suppression by the renin inhibitor remikiren. (PMID: 8206619) Hilgers K.F. … Mann J.F. (Hypertension 1994) 23 25 26
  5. Comparative effects of three different potent renin inhibitors in primates. (PMID: 8319997) Clozel J.P. … Fischli W. (Hypertension 1993) 23 25 26

Products for REN Gene

Sources for REN Gene