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Aliases for REM2 Gene

Aliases for REM2 Gene

  • RAS (RAD And GEM)-Like GTP Binding 2 2 3 5
  • Rad And Gem-Like GTP-Binding Protein 2 4
  • RAS (RAD And GEM) Like GTP Binding 2 2

External Ids for REM2 Gene

Previous GeneCards Identifiers for REM2 Gene

  • GC14U990398
  • GC14P022423
  • GC14P023352
  • GC14P003469

Summaries for REM2 Gene

GeneCards Summary for REM2 Gene

REM2 (RAS (RAD And GEM)-Like GTP Binding 2) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for REM2 Gene

  • Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REM2 Gene

Genomics for REM2 Gene

Regulatory Elements for REM2 Gene

Genomic Location for REM2 Gene

Chromosome:
14
Start:
22,883,165 bp from pter
End:
22,887,686 bp from pter
Size:
4,522 bases
Orientation:
Plus strand

Genomic View for REM2 Gene

Genes around REM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REM2 Gene

Proteins for REM2 Gene

  • Protein details for REM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYK8-REM2_HUMAN
    Recommended name:
    GTP-binding protein REM 2
    Protein Accession:
    Q8IYK8
    Secondary Accessions:
    • B7Z5P1
    • Q8N8R8

    Protein attributes for REM2 Gene

    Size:
    340 amino acids
    Molecular mass:
    37139 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35663.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04746.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for REM2 Gene

    Alternative splice isoforms for REM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REM2 Gene

Proteomics data for REM2 Gene at MOPED

Post-translational modifications for REM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for REM2

No data available for DME Specific Peptides for REM2 Gene

Domains & Families for REM2 Gene

Gene Families for REM2 Gene

Suggested Antigen Peptide Sequences for REM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IYK8

UniProtKB/Swiss-Prot:

REM2_HUMAN :
  • Belongs to the small GTPase superfamily. RGK family.
Family:
  • Belongs to the small GTPase superfamily. RGK family.
genes like me logo Genes that share domains with REM2: view

Function for REM2 Gene

Molecular function for REM2 Gene

UniProtKB/Swiss-Prot Function:
Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.

Phenotypes for REM2 Gene

genes like me logo Genes that share phenotypes with REM2: view

Animal Model Products

miRNA for REM2 Gene

miRTarBase miRNAs that target REM2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REM2 Gene

Localization for REM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REM2 Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REM2 Gene COMPARTMENTS Subcellular localization image for REM2 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for REM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with REM2: view

Pathways & Interactions for REM2 Gene

SuperPathways for REM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with REM2: view

No data available for Pathways by source and SIGNOR curated interactions for REM2 Gene

Drugs & Compounds for REM2 Gene

(1) Drugs for REM2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with REM2: view

Transcripts for REM2 Gene

mRNA/cDNA for REM2 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for REM2 Gene

RAS (RAD and GEM)-like GTP binding 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for REM2 Gene

No ASD Table

Relevant External Links for REM2 Gene

GeneLoc Exon Structure for
REM2
ECgene alternative splicing isoforms for
REM2

Expression for REM2 Gene

mRNA expression in normal human tissues for REM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REM2 Gene

This gene is overexpressed in Whole Blood (x21.9).

Protein differential expression in normal tissues from HIPED for REM2 Gene

This gene is overexpressed in Fetal Brain (38.1), Frontal cortex (24.0), and Brain (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for REM2 Gene



SOURCE GeneReport for Unigene cluster for REM2 Gene Hs.444911

genes like me logo Genes that share expression patterns with REM2: view

Protein tissue co-expression partners for REM2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for REM2 Gene

Orthologs for REM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for REM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia REM2 35
  • 91.76 (n)
  • 94.12 (a)
REM2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia REM2 35
  • 89.61 (n)
  • 91.18 (a)
REM2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rem2 35
  • 87.65 (n)
  • 92.65 (a)
Rem2 16
Rem2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia REM2 35
  • 99.51 (n)
  • 99.41 (a)
REM2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rem2 35
  • 87.35 (n)
  • 92.65 (a)
oppossum
(Monodelphis domestica)
Mammalia REM2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia REM2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia REM2 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rem2 35
  • 61.48 (n)
  • 61.94 (a)
zebrafish
(Danio rerio)
Actinopterygii rem2 36
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42541 36
  • 7 (a)
ManyToMany
Rgk1 36
  • 17 (a)
ManyToMany
Rgk2 36
  • 12 (a)
ManyToMany
Rgk3 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y52B11A.4 36
  • 17 (a)
OneToMany
Species with no ortholog for REM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REM2 Gene

ENSEMBL:
Gene Tree for REM2 (if available)
TreeFam:
Gene Tree for REM2 (if available)

Paralogs for REM2 Gene

Paralogs for REM2 Gene

(22) SIMAP similar genes for REM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with REM2: view

Variants for REM2 Gene

Sequence variations from dbSNP and Humsavar for REM2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs8014119 - 22,884,857(+) CTCTG(C/G)CTCGT reference, missense
rs2877492 -- 22,883,177(+) TGTGT(C/G)GGGGG upstream-variant-2KB, utr-variant-5-prime
rs3751490 -- 22,886,339(+) CACTT(A/G)CAATC intron-variant
rs4982700 -- 22,885,858(+) CTTCC(G/T)CCTCC intron-variant
rs10141277 -- 22,883,004(+) CATAA(C/T)TCAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for REM2 Gene

Variant ID Type Subtype PubMed ID
nsv901490 CNV Loss 21882294
nsv1214 CNV Loss 18451855

Variation tolerance for REM2 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REM2 Gene

HapMap Linkage Disequilibrium report
REM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REM2 Gene

Disorders for REM2 Gene

Relevant External Links for REM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REM2

No disorders were found for REM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REM2 Gene

Publications for REM2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. (PMID: 10727423) Finlin B.S. … Andres D.A. (Biochem. J. 2000) 2 3
  3. A loss-of-function analysis reveals that endogenous Rem2 promotes functional glutamatergic synapse formation and restricts dendritic complexity. (PMID: 23991227) Moore A.R. … Paradis S. (PLoS ONE 2013) 3
  4. Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase III+. (PMID: 22815963) Flynn R. … Zamponi G.W. (PLoS ONE 2012) 3
  5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3

Products for REM2 Gene

Sources for REM2 Gene

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