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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

REM2 Gene

protein-coding GIFtS: 46
GCID: GC14P023352

RAS (RAD and GEM)-like GTP binding 2

(Previous name: RAS (RAD and GEM) like GTP binding 2 )

Search for REM2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RAS (RAD And GEM)-Like GTP Binding 2¹ ²		GTP-Binding Protein REM 2²
Rad And Gem-Like GTP-Binding Protein 2² ³		Rad And Gem-Related 2 (Rat Homolog)²
FLJ38964¹		CD300LE⁵
RAS (RAD And GEM) Like GTP Binding 2¹		ICLM2⁵

External Ids:	HGNC: 20248¹	Entrez Gene: 161253²	Ensembl: ENSG00000139890⁷	OMIM: 609801⁵	UniProtKB: Q8IYK8³

Export aliases for REM2 gene to outside databases

Previous GC identifers: GC14U990398 GC14P022423 GC14P003469

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: REM2_HUMAN, Q8IYK8

Function: Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the REM2 gene promoter:
NF-1 NF-1/L AML1a Pax-2 Pax-2a E47 Hand1 ZID Pax-4a ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: REM2 promoter sequence

Search SABiosciences Chromatin IP Primers for REM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2

REM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REM2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P023352: view genomic region (about GC identifiers)

Start:	23,352,374 bp from pter	End:	23,356,895 bp from pter
Size:	4,522 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: REM2_HUMAN, Q8IYK8 (See protein sequence)

Recommended Name: GTP-binding protein REM 2

Size: 340 amino acids; 37139 Da

Subcellular location: Cell membrane (By similarity)

Sequence caution: Sequence=AAH35663.1; Type=Erroneous initiation; Sequence=BAC04746.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for REM2:

3CBQ (3D)

Secondary accessions: Q8N8R8

Explore the universe of human proteins at neXtProt for REM2: NX_Q8IYK8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IYK8

REM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_775798.2

ENSEMBL proteins:

ENSP00000267396 ENSP00000442774

Human Recombinant Protein Products for REM2:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: REM2 OriGene Protein Over-expression Lysate: REM2 OriGene Custom Protein Services for REM2
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	Novus Biologicals REM2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for REM2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016020	membrane	--	--

REM2 for ontologies About GeneDecksing

REM2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of REM2
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	Novus Biologicals REM2 Antibody
	Abcam antibodies for REM2
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	ThermoFisher Antibodies for REM2

Assay Products for REM2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for REM2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for REM2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

REM2 for domains About GeneDecksing

4 InterPro domains/families:

IPR025662 Sigma_54_int_dom_ATP-bd_1

IPR001806 Small_GTPase

IPR017358 Small_GTPase_GEM/REM/Rad

IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry Q8IYK8

ProtoNet protein and cluster: Q8IYK8

2 Blocks protein families:

IPB003577 Ras small GTPase

IPB003578 Ras small GTPase

UniProtKB/Swiss-Prot: REM2_HUMAN, Q8IYK8

Similarity: Belongs to the small GTPase superfamily. RGK family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: REM2_HUMAN, Q8IYK8

Function: Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005525	GTP binding	IEA	--

REM2 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for REM2

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REM2
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate REM2:
		hsa-miR-659 hsa-miR-1273 hsa-miR-3658 hsa-miR-591 hsa-miR-3653 hsa-miR-548b-3p hsa-miR-384
		SwitchGear 3'UTR luciferase reporter plasmid: REM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REM2 (see all 7) OriGene shRNA RFP: REM2 OriGene siRNA: REM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REM2
		Sirion Biotech Custom design and validation of potent shRNA sequences against REM2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for REM2
			Sirion Biotech Customized adenovirus for overexpression of REM2 Sirion Biotech Customized adenovirus for potent knockdown of REM2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REM2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: REM2 (NM_018965)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for REM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REM2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for REM2
		Search LifeMap BioReagents cell lines for REM2
		Sirion Biotech Customized stable knockdown cell line services for REM2 Sirion Biotech Customized inducible knockdown cell line services for REM2 Sirion Biotech Customized stable overexpressing cell line services for REM2 Sirion Biotech Customized inducible overexpressing cell line services for REM2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REM2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for REM2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for REM2 (Q8IYK8³ ENSP00000267396⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAZ	P63104³	I2D: score=1
TINF2	ENSP00000267415⁴	STRING: ENSP00000267415

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	--	--
GO:0007165	signal transduction	--	--
GO:0007264	small GTPase mediated signal transduction	IEA	--

REM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for REM2

1 HMDB Compound for REM2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about REM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for REM2 gene:

NM_173527.2

Unigene Cluster for REM2:

RAS (RAD and GEM)-like GTP binding 2

Hs.444911 [show with all ESTs]

Unigene Representative Sequence: NM_173527

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000267396(uc001whf.1) ENST00000536884(uc010tnd.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REM2
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate REM2:
		hsa-miR-659 hsa-miR-1273 hsa-miR-3658 hsa-miR-591 hsa-miR-3653 hsa-miR-548b-3p hsa-miR-384
		SwitchGear 3'UTR luciferase reporter plasmid: REM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REM2 (see all 7) OriGene shRNA RFP: REM2 OriGene siRNA: REM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REM2
		Sirion Biotech Custom design and validation of potent shRNA sequences against REM2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REM2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: REM2 (NM_018965)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for REM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat REM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REM2

Additional cDNA sequence:

AK096283.1 AK299238.1 BC035663.1

3 DOTS entries:

DT.304418 DT.75139570 DT.95071431

20 AceView cDNA sequences:

BU681760 BC035663 BM546743 AI701393 NM_173527 AI565608 AK096283 BF446778

H19231 BQ708131 BF110674 BE669923 AI912258 AA493359 AW269909 AA936248

AW664797 AW969505 AV750985 H19232

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

REM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCCACTTT

About this image

REM2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Dorsal Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Ventral Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See REM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for REM2

SOURCE GeneReport for Unigene cluster: Hs.444911

SABiosciences Custom PCR Arrays for REM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat REM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for REM2 gene from 4/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	REM2⁶	--	65(a)	1 ↔ 1	GL343879.1(24103-28580)
zebrafish (Danio rerio)	Actinopterygii	rem2⁶	RAS (RAD and GEM)-like GTP binding 2	37(a)	1 ↔ 1	2(38629171-38681494)
fruit fly (Drosophila melanogaster)	Insecta	Rgk2⁶ CG42541⁶ (see all 4)	--	9(a) 5(a) (see all 4)	many ↔ many many ↔ many (see all 4)	2R(14427090-14436472) X(3785530-3824611)
worm (Caenorhabditis elegans)	Secernentea	Y52B11A.4⁶	--	10(a)	1 → many	I(10979600-11004276)

ENSEMBL Gene Tree for REM2 (if available)
TreeFam Gene Tree for REM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for REM2 gene

REM1² RALA² RIT2² RIT1² RRAS² ERAS² RALB² NRAS²

RRAD² KRAS² GEM² RRAS2² HRAS² MRAS²

18/22 SIMAP similar genes for REM2 using alignment to 2 protein entries: REM2_HUMAN (see all proteins) (see all similar genes):

GEM RALB RRAD RALA MRAS NRAS

RIT1 HRAS KRAS DIRAS2 REM1 RIT2

RAP1A RERG RRAS2 DIRAS1 RAP1B RAP2C

REM2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72681960^1,2	C,F	--	23350478(+)	`AACCCG/AGGAGG`	1	--	us2k¹		5		WA CSA NA EA	362
rs117856724^1,2		--	23350508(+)	`TGATCG/ACACCA`	1	--	us2k¹		1		EA	120
rs187506975^1,2		--	23350536(+)	`CAATAA/GGGTGA`	1	--	us2k¹		0	--	--	--	--
rs192128310^1,2		--	23350695(+)	`TCTTCG/TGAAGT`	1	--	us2k¹		0	--	--	--	--
rs148491925^1,2		--	23350964(+)	`CAGTGA/GGTAAA`	1	--	us2k¹		0	--	--	--	--
rs145288000^1,2		--	23350990(+)	`AGCAGC/TTGAGG`	1	--	us2k¹		0	--	--	--	--
rs182372704^1,2		--	23351023(+)	`CCTGCA/CCTGTT`	1	--	us2k¹		0	--	--	--	--
rs116269891^1,2		--	23351189(+)	`CACAAT/AGTAGA`	1	--	us2k¹		1		WA	118
rs188066780^1,2		--	23351366(+)	`AAAAAC/TGGGGC`	1	--	us2k¹		0	--	--	--	--
rs115263845^1,2		--	23351391(+)	`GGAACG/TTGTGT`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for REM2 (23352374 - 23356895 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for REM2: --

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REM2

DNA2.0 Custom Variant and Variant Library Synthesis for REM2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

REM2 for disorders About MalaCards

REM2 for disorders About GeneDecksing

OMIM gene information: 609801 OMIM disorders: --

Export disorders for REM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for REM2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with REM2)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. (PubMed id 10727423)^{1, 3} Finlin B.S....Andres D.A. (2000)
Activity-dependent subcellular cotrafficking of the sm all GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIa. (PubMed id 22815963)¹ Flynn R....Zamponi G.W. (2012)
The GTPase Rem2 regulates synapse development and den dritic morphology. (PubMed id 21485012)¹ Ghiretti A.E. and Paradis S. (2011)
Rem2-targeted shRNAs reduce frequency of miniature ex citatory postsynaptic currents without altering voltage-gated CaA^a8_ currents. (PubMed id 21980534)¹ Wang H.G....Pitt G.S. (2011)
Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)¹ Lee O.H....Songyang Z. (2011)
Rem2 GTPase maintains survival of human embryonic ste m cells as well as enhancing reprogramming by regulating p53 and cyclin D1. (PubMed id 20231315)¹ Edel M.J....Izpisua Belmonte J.C. (2010)
An endothelial cell genetic screen identifies the GTPase Rem2 as a suppressor of p19ARF expression that promotes endothelial cell proliferation and angiogenesis. (PubMed id 18056257)¹ Bierings R....Edel M.J. (2008)
Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase. (PubMed id 15728182)¹ Finlin B.S....Andres D.A. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 161253	HGNC: 20248	AceView: FLJ38964	Ensembl:ENSG00000139890	euGenes: HUgn161253
ECgene: REM2	H-InvDB: REM2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for REM2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for REM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for REM2 gene:
Search GeneIP for patents involving REM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for REM2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REM2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REM2
	OriGene Protein Over-expression Lysate for REM2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for REM2		Browse 3'-UTR reporter clones for miRNA target validation
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat REM2
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REM2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REM2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REM2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REM2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REM2

	GenScript Custom Purified and Recombinant Proteins Services for REM2		GenScript cDNA clones with any tag delivered in your preferred vector for REM2
	GenScript Custom Assay Services for REM2		GenScript Custom Superior Antibodies Services for REM2
	GenScript Custom overexpressing Cell Line Services for REM2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in REM2 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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REM2 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REM2

	SwitchGear 3'UTR luciferase reporter plasmids for REM2
	SwitchGear Promoter luciferase reporter plasmids for REM2

ThermoFisher Antibodies for REM2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REM2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for REM2

Sirion Biotech Customized:

	stable knockdown cell line services for REM2
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	design and validation of potent shRNA sequences against REM2
	adenovirus for potent knockdown of REM2
	adenovirus for overexpression of REM2
	stable overexpressing cell line services for REM2
	inducible overexpressing cell line services for REM2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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REM2 Gene

RAS (RAD and GEM)-like GTP binding 2

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Families
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Export list of displayed genes

REM2 Gene

RAS (RAD and GEM)-like GTP binding 2

Aliasesfor REM2 gene

Summariesfor REM2 gene

Genomic Viewsfor REM2 gene

Proteinsfor REM2 gene

Protein Domains /Familiesfor REM2 gene

Functionfor REM2 gene

Pathways & Interactionsfor REM2 gene

Drugs & Compoundsfor REM2 gene

Transcriptsfor REM2 gene

Expression for REM2 gene

Orthologsfor REM2 gene

Paralogsfor REM2 gene

Genomic Variantsfor REM2 gene

Disorders / Diseasesfor REM2 gene

Publicationsfor REM2 gene

External Searches for REM2 gene

Genome Databases showing REM2 gene

Other Databases showing REM2 gene

Specialized Databases showing REM2 gene

Intellectual Propertyfor REM2 gene

Productsfor REM2 gene

View Random Gene

Aliases
for REM2 gene

Summaries
for REM2 gene

Genomic Views
for REM2 gene

Proteins
for REM2 gene

Protein Domains /
Families
for REM2 gene

Function
for REM2 gene

Pathways & Interactions
for REM2 gene

Drugs & Compounds
for REM2 gene

Transcripts
for REM2 gene

Expression
for REM2 gene

Orthologs
for REM2 gene

Paralogs
for REM2 gene

Genomic Variants
for REM2 gene

Disorders / Diseases
for REM2 gene

Publications
for REM2 gene

Intellectual Property
for REM2 gene

Products
for REM2 gene