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Aliases for REM2 Gene

Aliases for REM2 Gene

  • RAS (RAD And GEM)-Like GTP Binding 2 2 3
  • Rad And Gem-Like GTP-Binding Protein 2 4
  • RAS (RAD And GEM) Like GTP Binding 2 2
  • CD300LE 6
  • ICLM2 6

External Ids for REM2 Gene

Previous GeneCards Identifiers for REM2 Gene

  • GC14U990398
  • GC14P022423
  • GC14P023352
  • GC14P003469

Summaries for REM2 Gene

GeneCards Summary for REM2 Gene

REM2 (RAS (RAD And GEM)-Like GTP Binding 2) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for REM2 Gene

  • Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REM2 Gene

Genomics for REM2 Gene

Regulatory Elements for REM2 Gene

Genomic Location for REM2 Gene

Start:
22,883,113 bp from pter
End:
22,887,686 bp from pter
Size:
4,574 bases
Orientation:
Plus strand

Genomic View for REM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REM2 Gene

Proteins for REM2 Gene

  • Protein details for REM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYK8-REM2_HUMAN
    Recommended name:
    GTP-binding protein REM 2
    Protein Accession:
    Q8IYK8
    Secondary Accessions:
    • B7Z5P1
    • Q8N8R8

    Protein attributes for REM2 Gene

    Size:
    340 amino acids
    Molecular mass:
    37139 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35663.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04746.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for REM2 Gene

    Alternative splice isoforms for REM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REM2 Gene

Proteomics data for REM2 Gene at MOPED

Post-translational modifications for REM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for REM2 Gene

Domains for REM2 Gene

Suggested Antigen Peptide Sequences for REM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IYK8

UniProtKB/Swiss-Prot:

REM2_HUMAN :
  • Q8IYK8
Family:
  • Belongs to the small GTPase superfamily. RGK family.
genes like me logo Genes that share domains with REM2: view

No data available for Gene Families for REM2 Gene

Function for REM2 Gene

Molecular function for REM2 Gene

UniProtKB/Swiss-Prot Function: Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.

Gene Ontology (GO) - Molecular Function for REM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with REM2: view

Animal Model Products

CRISPR Products

miRNA for REM2 Gene

miRTarBase miRNAs that target REM2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for REM2 Gene

Localization for REM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REM2 Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REM2 Gene COMPARTMENTS Subcellular localization image for REM2 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for REM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with REM2: view

Pathways for REM2 Gene

SuperPathways for REM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008152 metabolic process IEA --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with REM2: view

No data available for Pathways by source for REM2 Gene

Compounds for REM2 Gene

(1) HMDB Compounds for REM2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with REM2: view

Transcripts for REM2 Gene

mRNA/cDNA for REM2 Gene

(20) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for REM2 Gene

RAS (RAD and GEM)-like GTP binding 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REM2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REM2 Gene

No ASD Table

Relevant External Links for REM2 Gene

GeneLoc Exon Structure for
REM2
ECgene alternative splicing isoforms for
REM2

Expression for REM2 Gene

mRNA expression in normal human tissues for REM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REM2 Gene

This gene is overexpressed in Whole Blood (21.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for REM2 Gene

SOURCE GeneReport for Unigene cluster for REM2 Gene Hs.444911

genes like me logo Genes that share expressions with REM2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for REM2 Gene

Orthologs for REM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for REM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REM2 35
  • 99.51 (n)
  • 99.41 (a)
REM2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia REM2 35
  • 91.76 (n)
  • 94.12 (a)
REM2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia REM2 35
  • 89.61 (n)
  • 91.18 (a)
REM2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rem2 35
  • 87.65 (n)
  • 92.65 (a)
Rem2 16
Rem2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia REM2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia REM2 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rem2 35
  • 87.35 (n)
  • 92.65 (a)
lizard
(Anolis carolinensis)
Reptilia REM2 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rem2 35
  • 61.48 (n)
  • 61.94 (a)
zebrafish
(Danio rerio)
Actinopterygii rem2 36
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42541 36
  • 7 (a)
ManyToMany
Rgk1 36
  • 17 (a)
ManyToMany
Rgk2 36
  • 12 (a)
ManyToMany
Rgk3 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y52B11A.4 36
  • 17 (a)
OneToMany
Species with no ortholog for REM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REM2 Gene

ENSEMBL:
Gene Tree for REM2 (if available)
TreeFam:
Gene Tree for REM2 (if available)

Paralogs for REM2 Gene

Paralogs for REM2 Gene

Selected SIMAP similar genes for REM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with REM2: view

Variants for REM2 Gene

Sequence variations from dbSNP and Humsavar for REM2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2877492 -- 22,883,177(+) TGTGT(C/G)GGGGG upstream-variant-2KB, utr-variant-5-prime
rs3751490 -- 22,886,339(+) CACTT(A/G)CAATC intron-variant
rs4982700 -- 22,885,858(+) CTTCC(G/T)CCTCC intron-variant
rs8014119 - 22,884,857(+) CTCTG(C/G)CTCGT missense, reference
rs8021159 -- 22,885,991(+) TATGC(C/T)TCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REM2 Gene

Variant ID Type Subtype PubMed ID
nsv901490 CNV Loss 21882294
nsv1214 CNV Loss 18451855

Relevant External Links for REM2 Gene

HapMap Linkage Disequilibrium report
REM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REM2 Gene

Disorders for REM2 Gene

No disorders were found for REM2 Gene.

No data available for UniProtKB/Swiss-Prot for REM2 Gene

Publications for REM2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. (PMID: 10727423) Finlin B.S. … Andres D.A. (Biochem. J. 2000) 2 3
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for REM2 Gene

Sources for REM2 Gene

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