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REM2 Gene

protein-coding   GIFtS: 49
GCID: GC14P023352

RAS (RAD And GEM)-Like GTP Binding 2

(Previous name: RAS (RAD and GEM) like GTP binding 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAS (RAD And GEM)-Like GTP Binding 21 2     Rad And Gem-Related 2 (Rat Homolog)2
Rad And Gem-Like GTP-Binding Protein 22 3     CD300LE5
RAS (RAD And GEM) Like GTP Binding 21     ICLM25
GTP-Binding Protein REM 22     

External Ids:    HGNC: 202481   Entrez Gene: 1612532   Ensembl: ENSG000001398907   OMIM: 6098015   UniProtKB: Q8IYK83   

Export aliases for REM2 gene to outside databases

Previous GC identifers: GC14U990398 GC14P022423 GC14P003469


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for REM2 Gene:
REM2 (RAS (RAD and GEM)-like GTP binding 2) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is REM1.

UniProtKB/Swiss-Prot: REM2_HUMAN, Q8IYK8
Function: Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the REM2 gene promoter:
         NF-1   NF-1/L   AML1a   Pax-2   Pax-2a   E47   Hand1   ZID   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREM2 promoter sequence
   Search Chromatin IP Primers for REM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

REM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REM2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P023352:  view genomic region     (about GC identifiers)

Start:
23,352,374 bp from pter      End:
23,356,895 bp from pter
Size:
4,522 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: REM2_HUMAN, Q8IYK8 (See protein sequence)
Recommended Name: GTP-binding protein REM 2  
Size: 340 amino acids; 37139 Da
Sequence caution: Sequence=AAH35663.1; Type=Erroneous initiation; Sequence=BAC04746.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for REM2:
3CBQ (3D)    
Secondary accessions: Q8N8R8

Explore the universe of human proteins at neXtProt for REM2: NX_Q8IYK8

Explore proteomics data for REM2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See REM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775798.2  
    ENSEMBL proteins: 
     ENSP00000267396   ENSP00000442774  

    REM2 Human Recombinant Protein Products:

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    OriGene Purified Protein for REM2
    OriGene Protein Over-expression Lysate for REM2
    OriGene MassSpec for REM2
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    Novus Biologicals REM2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for REM2

     
    Search eBioscience for Proteins for REM2 

     
    antibodies-online proteins for REM2 (3 products) 

     
    Search antibodies-online for peptides for REM2

    REM2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of REM2
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    Novus Biologicals REM2 Antibody
    Abcam antibodies for REM2
    Cloud-Clone Corp. Antibodies for REM2
    ThermoFisher Antibodies for REM2
    antibodies-online antibodies for REM2 (5 products) 

    REM2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for REM2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for REM2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for REM2
    Cloud-Clone Corp. CLIAs for REM2
    Search eBioscience for ELISAs for REM2 
    antibodies-online kits for REM2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR025662 Sigma_54_int_dom_ATP-bd_1
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR017358 Small_GTPase_GEM/REM/Rad
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q8IYK8

    ProtoNet protein and cluster: Q8IYK8

    2 Blocks protein domains:
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: REM2_HUMAN, Q8IYK8
    Similarity: Belongs to the small GTPase superfamily. RGK family


    Find genes that share domains with REM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REM2_HUMAN, Q8IYK8
    Function: Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with REM2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for REM2

    miRNA
    Products:
        
    miRTarBase miRNAs that target REM2:
    hsa-mir-1 (MIRT023952)

    Block miRNA regulation of human, mouse, rat REM2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate REM2:
    hsa-miR-659 hsa-miR-1273 hsa-miR-3658 hsa-miR-591 hsa-miR-3653 hsa-miR-548b-3p hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmidREM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for REM2
    Predesigned siRNA for gene silencing in human, mouse, rat REM2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for REM2

    Clone
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    OriGene clones in human, mouse for REM2 (see all 6)
    OriGene ORF clones in mouse, rat for REM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REM2 (NM_018965)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REM2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for REM2
    Browse ESI BIO Cell Lines and PureStem Progenitors for REM2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    REM2_HUMAN, Q8IYK8: Cell membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    plasma membrane2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with REM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for REM2
    Interactions:

        Search GeneGlobe Interaction Network for REM2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for REM2 (Q8IYK83 ENSP000002673964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631043, ENSP000003095034I2D: score=1 STRING: ENSP00000309503
    TINF2ENSP000002674154STRING: ENSP00000267415
    EIF3DENSP000002161904STRING: ENSP00000216190
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    Find genes that share ontologies with REM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for REM2

    1 HMDB Compound for REM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for REM2 gene: 
    NM_173527.2  

    Unigene Cluster for REM2:

    RAS (RAD and GEM)-like GTP binding 2
    Hs.444911  [show with all ESTs]
    Unigene Representative Sequence: NM_173527
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267396(uc001whf.1) ENST00000536884(uc010tnd.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat REM2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate REM2:
    hsa-miR-659 hsa-miR-1273 hsa-miR-3658 hsa-miR-591 hsa-miR-3653 hsa-miR-548b-3p hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmidREM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for REM2
    Predesigned siRNA for gene silencing in human, mouse, rat REM2
    Clone
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    OriGene clones in human, mouse for REM2 (see all 6)
    OriGene ORF clones in mouse, rat for REM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REM2 (NM_018965)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REM2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for REM2
    OriGene qSTAR qPCR primer pairs in human, mouse for REM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REM2
      QuantiTect SYBR Green Assays in human, mouse, rat REM2
      QuantiFast Probe-based Assays in human, mouse, rat REM2

    Additional mRNA sequence: 

    AK096283.1 AK299238.1 BC035663.1 

    3 DOTS entries:

    DT.304418  DT.75139570  DT.95071431 

    20 AceView cDNA sequences:

    BU681760 BM546743 NM_173527 AI701393 BC035663 AA936248 AA493359 AW269909 
    BF446778 AK096283 BE669923 AI565608 AI912258 H19231 BF110674 BQ708131 
    AW664797 AW969505 AV750985 H19232 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    REM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCCACTTT
    REM2 Expression
    About this image


    REM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    REM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444911
        Custom PCR Arrays for REM2
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    QuantiFast Probe-based Assays in human, mouse, rat REM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for REM2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rem21 , 5 rad and gem related GTP binding protein 21, 5 87.65(n)1
    92.65(a)1
      14 (27.80 cM)5
    1407431  NM_080726.31  NP_542764.21 
     544761005 
    lizard
    (Anolis carolinensis)
    Reptilia REM26
    RAS (RAD and GEM)-like GTP binding 2
    67(a)
    1 ↔ 1
    GL343879.1(17394-30191)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rem21 RAS (RAD and GEM)-like GTP binding 2 61.48(n)
    61.94(a)
      100488324  XM_002941509.2  XP_002941555.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rem26
    RAS (RAD and GEM)-like GTP binding 2
    38(a)
    1 ↔ 1
    2(38629171-38681494) ENSDARG00000074064
    fruit fly
    (Drosophila melanogaster)
    Insecta CG425416
    Rgk36
    (see all 4)
    Rgk3
    (see all 4)
    7(a)
    19(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    X(3785530-3824611)
    2R(17143319-17167878)
    worm
    (Caenorhabditis elegans)
    Secernentea Y52B11A.46
    Protein Y52B11A.4 (Y52B11A.4) mRNA, complete cds
    17(a)
    1 → many
    I(10979607-11004283) WBGene00013124


    ENSEMBL Gene Tree for REM2 (if available)
    TreeFam Gene Tree for REM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for REM2 gene
    REM12  RALA2  RRAS2  RALB2  ERAS2  RRAD2  NRAS2  KRAS2  
    GEM2  RRAS22  HRAS2  MRAS2  
    Selected SIMAP similar genes for REM2 using alignment to 2 protein entries:     REM2_HUMAN (see all proteins) (see all similar genes):
    GEM    RALB    RRAD    RALA    MRAS    NRAS
    RIT1    HRAS    KRAS    DIRAS2    REM1    RIT2
    RAP1A    RERG    RRAS2    DIRAS1    RAP1B    RAP2C

    Find genes that share paralogs with REM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for REM2 (see all 154)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920457841,2
    --3467570(+) TACCAA/GGTGGT 1 -- us2k10--------
    rs1828690081,2
    --3467583(+) ATTTAC/GAGCCG 1 -- us2k10--------
    rs726819601,2
    C,F--23350478(+) AACCCG/AGGAGG 1 -- us2k15Minor allele frequency- A:0.14WA CSA NA EA 362
    rs1178567241,2
    F--23350508(+) TGATCG/ACACCA 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1875069751,2
    --23350536(+) CAATAA/GGGTGA 1 -- us2k10--------
    rs1921283101,2
    --23350695(+) TCTTCG/TGAAGT 1 -- us2k10--------
    rs1484919251,2
    --23350964(+) CAGTGA/GGTAAA 1 -- us2k10--------
    rs1452880001,2
    --23350990(+) AGCAGC/TTGAGG 1 -- us2k10--------
    rs1823727041,2
    --23351023(+) CCTGCA/CCTGTT 1 -- us2k10--------
    rs1162698911,2
    F--23351189(+) CACAAT/AGTAGA 1 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for REM2 (23352374 - 23356895 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for REM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901490CNV Loss21882294
    nsv1214CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing REM2
    DNA2.0 Custom Variant and Variant Library Synthesis for REM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609801    OMIM disorders: --


    Find genes that share disorders with REM2           About GenesLikeMe


    Export disorders for REM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for REM2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with REM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. (PubMed id 10727423)1, 3 Finlin B.S....Andres D.A. (Biochem. J. 2000)
    4. Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase III+. (PubMed id 22815963)1 Flynn R....Zamponi G.W. (PLoS ONE 2012)
    5. The GTPase Rem2 regulates synapse development and dendritic morphology. (PubMed id 21485012)1 Ghiretti A.E. and Paradis S. (Dev Neurobiol 2011)
    6. Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated CaA^a8_ currents. (PubMed id 21980534)1 Wang H.G....Pitt G.S. (PLoS ONE 2011)
    7. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    8. Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1. (PubMed id 20231315)1 Edel M.J....Izpisua Belmonte J.C. (amp 2010)
    9. An endothelial cell genetic screen identifies the GTPase Rem2 as a suppressor of p19ARF expression that promotes endothelial cell proliferation and angiogenesis. (PubMed id 18056257)1 Bierings R....Edel M.J. (J. Biol. Chem. 2008)
    10. Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase. (PubMed id 15728182)1 Finlin B.S....Andres D.A. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 161253 HGNC: 20248 AceView: FLJ38964 Ensembl:ENSG00000139890 euGenes: HUgn161253
    ECgene: REM2 H-InvDB: REM2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for REM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for REM2 gene:
    Search GeneIP for patents involving REM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     EMD Millipore Mono- and Polyclonal Antibodies for the study of REM2
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     antibodies-online antibodies for REM2 (5 products)
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      Search antibodies-online for peptides for REM2
     antibodies-online proteins for REM2 (3 products)
           
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