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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REM2 Gene

protein-coding   GIFtS: 49
GCID: GC14P023352

RAS (RAD And GEM)-Like GTP Binding 2

(Previous name: RAS (RAD and GEM) like GTP binding 2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAS (RAD And GEM)-Like GTP Binding 21 2     Rad And Gem-Related 2 (Rat Homolog)2
Rad And Gem-Like GTP-Binding Protein 22 3     CD300LE5
RAS (RAD And GEM) Like GTP Binding 21     ICLM25
GTP-Binding Protein REM 22     

External Ids:    HGNC: 202481   Entrez Gene: 1612532   Ensembl: ENSG000001398907   OMIM: 6098015   UniProtKB: Q8IYK83   

Export aliases for REM2 gene to outside databases

Previous GC identifers: GC14U990398 GC14P022423 GC14P003469


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for REM2 Gene: 
REM2 (RAS (RAD and GEM)-like GTP binding 2) is a protein-coding gene. Diseases associated with REM2 include endotheliitis. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is REM1.

UniProtKB/Swiss-Prot: REM2_HUMAN, Q8IYK8
Function: Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REM2 gene promoter:
         NF-1   NF-1/L   AML1a   Pax-2   Pax-2a   E47   Hand1   ZID   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for REM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

REM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REM2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P023352:  view genomic region     (about GC identifiers)

Start:
23,352,374 bp from pter      End:
23,356,895 bp from pter
Size:
4,522 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: REM2_HUMAN, Q8IYK8 (See protein sequence)
Recommended Name: GTP-binding protein REM 2  
Size: 340 amino acids; 37139 Da
Subcellular location: Cell membrane (By similarity)
Sequence caution: Sequence=AAH35663.1; Type=Erroneous initiation; Sequence=BAC04746.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for REM2:
3CBQ (3D)    
Secondary accessions: Q8N8R8

Explore the universe of human proteins at neXtProt for REM2: NX_Q8IYK8

Explore proteomics data for REM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IYK8

  • REM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    REM2 Protein Expression
    REFSEQ proteins: NP_775798.2  
    ENSEMBL proteins: 
     ENSP00000267396   ENSP00000442774  

    Human Recombinant Protein Products for REM2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for REM2
    OriGene Protein Over-expression Lysate for REM2
    OriGene MassSpec for REM2 
    OriGene Custom Protein Services for REM2
    GenScript Custom Purified and Recombinant Proteins Services for REM2
    Novus Biologicals REM2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for REM2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    REM2 for ontologies           About GeneDecksing



    REM2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of REM2
    Browse R&D Systems for Antibodies
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    Novus Biologicals REM2 Antibody
    Abcam antibodies for REM2
    Cloud-Clone Corp. Antibodies for REM2 
    ThermoFisher Antibodies for REM2
    LSBio Antibodies in human, mouse, rat for REM2 

    Assay Products for REM2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for REM2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for REM2 
    Cloud-Clone Corp. CLIAs for REM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR025662 Sigma_54_int_dom_ATP-bd_1
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR017358 Small_GTPase_GEM/REM/Rad
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q8IYK8

    ProtoNet protein and cluster: Q8IYK8

    2 Blocks protein domains:
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: REM2_HUMAN, Q8IYK8
    Similarity: Belongs to the small GTPase superfamily. RGK family


    REM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REM2_HUMAN, Q8IYK8
    Function: Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--
         
    REM2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for REM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for REM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REM2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REM2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate REM2:
    hsa-miR-659 hsa-miR-1273 hsa-miR-3658 hsa-miR-591 hsa-miR-3653 hsa-miR-548b-3p hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmidREM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for REM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REM2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for REM2
    Sirion Biotech Customized adenovirus for overexpression of REM2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for REM2 (see all 7)
    OriGene ORF clones in mouse, rat for REM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REM2 (NM_018965)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REM2
    Sirion Biotech Customized lentivirus for stable overexpression of REM2 
                         Customized lentivirus expression plasmids for stable overexpression of REM2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for REM2
    Search LifeMap BioReagents cell lines for REM2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for REM2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for REM2 (Q8IYK83 ENSP000002673964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631043I2D: score=1 
    TINF2ENSP000002674154STRING: ENSP00000267415
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    REM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REM2

    1 HMDB Compound for REM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about REM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for REM2 gene: 
    NM_173527.2  

    Unigene Cluster for REM2:

    RAS (RAD and GEM)-like GTP binding 2
    Hs.444911  [show with all ESTs]
    Unigene Representative Sequence: NM_173527
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267396(uc001whf.1) ENST00000536884(uc010tnd.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REM2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate REM2:
    hsa-miR-659 hsa-miR-1273 hsa-miR-3658 hsa-miR-591 hsa-miR-3653 hsa-miR-548b-3p hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmidREM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for REM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REM2
    Clone
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    OriGene clones in human, mouse for REM2 (see all 7)
    OriGene ORF clones in mouse, rat for REM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REM2 (NM_018965)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REM2
    Sirion Biotech Customized lentivirus for stable overexpression of REM2 
                         Customized lentivirus expression plasmids for stable overexpression of REM2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for REM2
    OriGene qSTAR qPCR primer pairs in human, mouse for REM2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REM2

    Additional mRNA sequence: 

    AK096283.1 AK299238.1 BC035663.1 

    3 DOTS entries:

    DT.304418  DT.75139570  DT.95071431 

    20 AceView cDNA sequences:

    NM_173527 BC035663 BU681760 AI701393 BM546743 AA936248 AK096283 BQ708131 
    BE669923 AI565608 AI912258 H19231 AA493359 BF446778 BF110674 AW269909 
    AW664797 AW969505 AV750985 H19232 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REM2 expression in normal human tissues (normalized intensities)      REM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCCACTTT
    REM2 Expression
    About this image


    REM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Blood (Hematopoietic System)
             neutrophils   

    See REM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REM2

    SOURCE GeneReport for Unigene cluster: Hs.444911
        SABiosciences Custom PCR Arrays for REM2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for REM2
    OriGene qSTAR qPCR primer pairs in human, mouse for REM2
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REM2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for REM2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rem21 , 5 rad and gem related GTP binding protein 21, 5 87.65(n)1
    92.65(a)1
      14 (27.80 cM)5
    1407431  NM_080726.31  NP_542764.21 
     544761005 
    lizard
    (Anolis carolinensis)
    Reptilia REM26
    RAS (RAD and GEM)-like GTP binding 2
    66(a)
    1 ↔ 1
    GL343879.1(17394-30191)
    zebrafish
    (Danio rerio)
    Actinopterygii rem26
    RAS (RAD and GEM)-like GTP binding 2
    35(a)
    1 ↔ 1
    2(38629171-38681494)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG425416
    Rgk36
    (see all 4)
    Rgk3
    (see all 4)
    6(a)
    17(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    X(3785530-3824611)
    2R(17143319-17167878)


    ENSEMBL Gene Tree for REM2 (if available)
    TreeFam Gene Tree for REM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for REM2 gene
    REM12  GEM2  RRAS22  MRAS2  RRAS2  ERAS2  RRAD2  
    18/22 SIMAP similar genes for REM2 using alignment to 2 protein entries:     REM2_HUMAN (see all proteins) (see all similar genes):
    GEM    RALB    RRAD    RALA    MRAS    NRAS
    RIT1    HRAS    KRAS    DIRAS2    REM1    RIT2
    RAP1A    RERG    RRAS2    DIRAS1    RAP1B    RAP2C

    REM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/154 SNPs in REM2 are shown (see all 154)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920457841,2
    --3467570(+) TACCAA/GGTGGT 1 -- us2k10--------
    rs1828690081,2
    --3467583(+) ATTTAC/GAGCCG 1 -- us2k10--------
    rs726819601,2
    C,F--23350478(+) AACCCG/AGGAGG 1 -- us2k15Minor allele frequency- A:0.14WA CSA NA EA 362
    rs1178567241,2
    F--23350508(+) TGATCG/ACACCA 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1875069751,2
    --23350536(+) CAATAA/GGGTGA 1 -- us2k10--------
    rs1921283101,2
    --23350695(+) TCTTCG/TGAAGT 1 -- us2k10--------
    rs1484919251,2
    --23350964(+) CAGTGA/GGTAAA 1 -- us2k10--------
    rs1452880001,2
    --23350990(+) AGCAGC/TTGAGG 1 -- us2k10--------
    rs1823727041,2
    --23351023(+) CCTGCA/CCTGTT 1 -- us2k10--------
    rs1162698911,2
    F--23351189(+) CACAAT/AGTAGA 1 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for REM2 (23352374 - 23356895 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for REM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv901490CNV Loss21882294
    nsv1214CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing REM2
    DNA2.0 Custom Variant and Variant Library Synthesis for REM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609801    OMIM disorders: --

    2 diseases for REM2:    About MalaCards
    endotheliitis    


    REM2 for disorders           About GeneDecksing


    Export disorders for REM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REM2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with REM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. (PubMed id 10727423)1, 3 Finlin B.S....Andres D.A. (2000)
    4. Activity-dependent subcellular cotrafficking of the sm all GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIa. (PubMed id 22815963)1 Flynn R....Zamponi G.W. (2012)
    5. The GTPase Rem2 regulates synapse development and den dritic morphology. (PubMed id 21485012)1 Ghiretti A.E. and Paradis S. (2011)
    6. Rem2-targeted shRNAs reduce frequency of miniature ex citatory postsynaptic currents without altering voltage-gated CaA^a8_ currents. (PubMed id 21980534)1 Wang H.G....Pitt G.S. (2011)
    7. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    8. Rem2 GTPase maintains survival of human embryonic ste m cells as well as enhancing reprogramming by regulating p53 and cyclin D1. (PubMed id 20231315)1 Edel M.J....Izpisua Belmonte J.C. (2010)
    9. An endothelial cell genetic screen identifies the GTPase Rem2 as a suppressor of p19ARF expression that promotes endothelial cell proliferation and angiogenesis. (PubMed id 18056257)1 Bierings R....Edel M.J. (2008)
    10. Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase. (PubMed id 15728182)1 Finlin B.S....Andres D.A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 161253 HGNC: 20248 AceView: FLJ38964 Ensembl:ENSG00000139890 euGenes: HUgn161253
    ECgene: REM2 H-InvDB: REM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for REM2 gene:
    Search GeneIP for patents involving REM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of REM2
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     Regulatory tfbs in REM2 promoter
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     Proteins for REM2
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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