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Aliases for REM1 Gene

Aliases for REM1 Gene

  • RAS (RAD And GEM)-Like GTP-Binding 1 2 3 5
  • GTPase-Regulating Endothelial Cell Sprouting 3 4
  • GES 3 4
  • Rad And Gem-Like GTP-Binding Protein 1 4
  • RAS (RAD And GEM)-Like GTP-Binding 2
  • GTPase GES 2
  • GD:REM 3
  • REM 4

External Ids for REM1 Gene

Previous HGNC Symbols for REM1 Gene

  • REM

Previous GeneCards Identifiers for REM1 Gene

  • GC20P030809
  • GC20P029526
  • GC20P030063
  • GC20P026851

Summaries for REM1 Gene

Entrez Gene Summary for REM1 Gene

  • The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for REM1 Gene

REM1 (RAS (RAD And GEM)-Like GTP-Binding 1) is a Protein Coding gene. Diseases associated with REM1 include Epileptic Encephalopathy, Childhood-Onset and Nominal Aphasia. GO annotations related to this gene include GTP binding and ferrous iron transmembrane transporter activity. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for REM1 Gene

  • Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REM1 Gene

Genomics for REM1 Gene

Regulatory Elements for REM1 Gene

Enhancers for REM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around REM1 on UCSC Golden Path with GeneCards custom track

Promoters for REM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around REM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for REM1 Gene

31,475,288 bp from pter
31,484,905 bp from pter
9,618 bases
Plus strand

Genomic View for REM1 Gene

Genes around REM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REM1 Gene

Proteins for REM1 Gene

  • Protein details for REM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein REM 1
    Protein Accession:
    Secondary Accessions:
    • E1P5L1
    • Q5TZR7
    • Q5TZR8
    • Q9NP57

    Protein attributes for REM1 Gene

    298 amino acids
    Molecular mass:
    32947 Da
    Quaternary structure:
    • In vitro, interacts with calmodulin in a calcium-dependent manner.

    Three dimensional structures from OCA and Proteopedia for REM1 Gene

neXtProt entry for REM1 Gene

Proteomics data for REM1 Gene at MOPED

Post-translational modifications for REM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for REM1 Gene

Domains & Families for REM1 Gene

Gene Families for REM1 Gene

Suggested Antigen Peptide Sequences for REM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. RGK family.
  • Belongs to the small GTPase superfamily. RGK family.
genes like me logo Genes that share domains with REM1: view

Function for REM1 Gene

Molecular function for REM1 Gene

UniProtKB/Swiss-Prot Function:
Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling.

Phenotypes for REM1 Gene

GenomeRNAi human phenotypes for REM1:
genes like me logo Genes that share phenotypes with REM1: view

Animal Model Products

miRNA for REM1 Gene

miRTarBase miRNAs that target REM1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REM1 Gene

Localization for REM1 Gene

Subcellular locations from

Jensen Localization Image for REM1 Gene COMPARTMENTS Subcellular localization image for REM1 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for REM1 Gene

Pathways & Interactions for REM1 Gene

SuperPathways for REM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REM1 Gene


No data available for Pathways by source and SIGNOR curated interactions for REM1 Gene

Drugs & Compounds for REM1 Gene

(1) Drugs for REM1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for REM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with REM1: view

Transcripts for REM1 Gene

mRNA/cDNA for REM1 Gene

Unigene Clusters for REM1 Gene

RAS (RAD and GEM)-like GTP-binding 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for REM1 Gene

No ASD Table

Relevant External Links for REM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REM1 Gene

mRNA expression in normal human tissues for REM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for REM1 Gene

This gene is overexpressed in Pancreatic juice (25.7), Uterus (24.0), and Heart (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for REM1 Gene

SOURCE GeneReport for Unigene cluster for REM1 Gene Hs.247729

mRNA Expression by UniProt/SwissProt for REM1 Gene

Tissue specificity: Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate.
genes like me logo Genes that share expression patterns with REM1: view

Protein tissue co-expression partners for REM1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for REM1 Gene

Orthologs for REM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for REM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia REM1 35
  • 87.92 (n)
  • 92.28 (a)
REM1 36
  • 92 (a)
(Canis familiaris)
Mammalia REM1 35
  • 89.37 (n)
  • 91.95 (a)
REM1 36
  • 76 (a)
(Mus musculus)
Mammalia Rem1 35
  • 85.19 (n)
  • 89.23 (a)
Rem1 16
Rem1 36
  • 89 (a)
(Pan troglodytes)
Mammalia REM1 35
  • 99.55 (n)
  • 99.66 (a)
REM1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rem1 35
  • 87.09 (n)
  • 90.57 (a)
(Monodelphis domestica)
Mammalia REM1 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
(Gallus gallus)
Aves REM1 35
  • 67.92 (n)
  • 67.04 (a)
REM1 36
  • 52 (a)
(Anolis carolinensis)
Reptilia REM1 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rem1 35
  • 60.95 (n)
  • 58.03 (a)
(Danio rerio)
Actinopterygii rem1 35
  • 64.63 (n)
  • 62.93 (a)
rem1 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007615 35
  • 47.9 (n)
  • 39.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rgk2 35
  • 50.41 (n)
  • 41.95 (a)
CG42541 36
  • 7 (a)
Rgk1 36
  • 19 (a)
Rgk2 36
  • 13 (a)
Rgk3 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea Y52B11A.4 36
  • 15 (a)
Species with no ortholog for REM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REM1 Gene

Gene Tree for REM1 (if available)
Gene Tree for REM1 (if available)

Paralogs for REM1 Gene

Paralogs for REM1 Gene

(18) SIMAP similar genes for REM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with REM1: view

Variants for REM1 Gene

Sequence variations from dbSNP and Humsavar for REM1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1006459 - 31,476,528(+) GGGCC(A/C/G)CCAGC reference, missense
rs2233829 - 31,476,620(+) AGAAA(C/G)CTTCA reference, missense
rs59730832 - 31,476,578(+) ATCCC(C/T)GGCTG reference, missense
rs215911 -- 31,479,520(+) CTTTC(A/G)CCTTG intron-variant
rs717064 -- 31,478,553(-) CAAAC(A/C)AGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REM1 Gene

Variant ID Type Subtype PubMed ID
nsv470546 CNV Gain 18288195
nsv458961 CNV Gain 19166990

Variation tolerance for REM1 Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.39; 92.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for REM1 Gene

Disorders for REM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for REM1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
epileptic encephalopathy, childhood-onset
  • childhood onset epileptic encephalopathy
nominal aphasia
  • anomia
- elite association - COSMIC cancer census association via MalaCards
Search REM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for REM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with REM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REM1 Gene

Publications for REM1 Gene

  1. Ges, a human GTPase of the Rad/Gem/Kir family, promotes endothelial cell sprouting and cytoskeleton reorganization. (PMID: 10831614) Pan J.Y. … Silberstein D.S. (J. Cell Biol. 2000) 2 3 4 23 67
  2. Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. (PMID: 14623965) Finlin B.S. … Andres D.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 23
  3. Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. (PMID: 22076634) Jhun B.S. … Jin Z.G. (Circ. Res. 2012) 2 3
  4. L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current. (PMID: 16648185) Crump S.M. … Satin J. (Am. J. Physiol. Heart Circ. Physiol. 2006) 3 23
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for REM1 Gene

Sources for REM1 Gene