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REM1 Gene

protein-coding   GIFtS: 49
GCID: GC20P030063

RAS (RAD And GEM)-Like GTP-Binding 1

(Previous name: RAS (RAD and GEM)-like GTP-binding)
(Previous symbol: REM)
  Search for REM1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAS (RAD And GEM)-Like GTP-Binding 11 2     RAS (RAD And GEM)-Like GTP-Binding1
GES2 3 5     GD:REM2
REM1 3     GTP-Binding Protein REM 12
GTPase-Regulating Endothelial Cell Sprouting2 3     Rad And Gem-Like GTP-Binding Protein 13
GTPase GES1     

External Ids:    HGNC: 159221   Entrez Gene: 289542   Ensembl: ENSG000000883207   OMIM: 6103885   UniProtKB: O756283   

Export aliases for REM1 gene to outside databases

Previous GC identifers: GC20P030809 GC20P029526 GC20P026851


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for REM1 Gene:
The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded
protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and
morphological changes in the cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for REM1 Gene:
REM1 (RAS (RAD and GEM)-like GTP-binding 1) is a protein-coding gene. GO annotations related to this gene include calmodulin binding and GTP binding. An important paralog of this gene is RALA.

UniProtKB/Swiss-Prot: REM1_HUMAN, O75628
Function: Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in
angiogenesis. May function in Ca(2+) signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the REM1 gene promoter:
         Elk-1   AML1a   AP-1   ATF-2   Evi-1   HEN1   Meis-1a   c-Jun   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREM1 promoter sequence
   Search Chromatin IP Primers for REM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

REM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REM1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P030063:  view genomic region     (about GC identifiers)

Start:
30,063,096 bp from pter      End:
30,072,708 bp from pter
Size:
9,613 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: REM1_HUMAN, O75628 (See protein sequence)
Recommended Name: GTP-binding protein REM 1  
Size: 298 amino acids; 32947 Da
Subunit: In vitro, interacts with calmodulin in a calcium-dependent manner
1 PDB 3D structure from and Proteopedia for REM1:
2NZJ (3D)    
Secondary accessions: E1P5L1 Q5TZR7 Q5TZR8 Q9NP57

Explore the universe of human proteins at neXtProt for REM1: NX_O75628

Explore proteomics data for REM1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See REM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054731.2  
    ENSEMBL proteins: 
     ENSP00000201979  

    REM1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for REM1

     
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    Search eBioscience for ELISAs for REM1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR017358 Small_GTPase_GEM/REM/Rad
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry O75628

    ProtoNet protein and cluster: O75628

    UniProtKB/Swiss-Prot: REM1_HUMAN, O75628
    Similarity: Belongs to the small GTPase superfamily. RGK family


    Find genes that share domains with REM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REM1_HUMAN, O75628
    Function: Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in
    angiogenesis. May function in Ca(2+) signaling

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005516calmodulin binding IEA--
    GO:0005525GTP binding IEA--
    GO:0015093ferrous iron transmembrane transporter activity ----
         
    Find genes that share ontologies with REM1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for REM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for REM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REM1

    miRNA
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    miRTarBase miRNAs that target REM1:
    hsa-mir-335-5p (MIRT019122)

    Block miRNA regulation of human, mouse, rat REM1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate REM1:
    hsa-miR-612 hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidREM1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for REM1
    Predesigned siRNA for gene silencing in human, mouse, rat REM1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): REM1 (NM_013372)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REM1
    Addgene plasmids for REM1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    golgi apparatus2
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0016020membrane IEA--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with REM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for REM1
    Interactions:

        Search GeneGlobe Interaction Network for REM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for REM1 (O756283 ENSP000002019794) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583, ENSP000002643354I2D: score=3 STRING: ENSP00000264335
    CACNB1Q026413, ENSP000003778404I2D: score=2 STRING: ENSP00000377840
    CACNB2Q082893, ENSP000003200254I2D: score=1 STRING: ENSP00000320025
    YWHAHQ049173, ENSP000002489754I2D: score=3 STRING: ENSP00000248975
    YWHAQP273483, ENSP000002380814I2D: score=3 STRING: ENSP00000238081
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    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IEA--
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----
    GO:0015684ferrous iron transport ----

    Find genes that share ontologies with REM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for REM1

    1 HMDB Compound for REM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for REM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 48.7 1 16790445 (1)
    calcium 41.9 14 14623965 (5), 16298391 (3), 17605760 (1), 16790445 (1) (see all 5)



    Find genes that share compounds with REM1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for REM1 gene: 
    NM_014012.5  

    Unigene Cluster for REM1:

    RAS (RAD and GEM)-like GTP-binding 1
    Hs.247729  [show with all ESTs]
    Unigene Representative Sequence: BC039813
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000201979(uc002wwa.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat REM1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate REM1:
    hsa-miR-612 hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidREM1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for REM1
    Predesigned siRNA for gene silencing in human, mouse, rat REM1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): REM1 (NM_013372)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REM1
    Addgene plasmids for REM1 
    Primer
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    OriGene qPCR primer pairs and template standards for REM1
    OriGene qSTAR qPCR primer pairs in human, mouse for REM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REM1
      QuantiTect SYBR Green Assays in human, mouse, rat REM1
      QuantiFast Probe-based Assays in human, mouse, rat REM1

    Additional mRNA sequence: 

    AF084465.1 AF152863.1 AK313060.1 BC039813.1 BT020078.1 BT020079.1 

    1 DOTS entry:

    DT.206043 

    Selected AceView cDNA sequences (see all 29):

    CR626669 BC039813 NM_014012 CA418563 AI335904 AF152863 CR598485 AI432309 
    BU681782 BX369234 AI088453 BI521371 BQ879420 AF084465 BF979509 AL546961 
    AI191821 AA232755 AW263945 AI984048 BF980129 BX090737 BI772170 BX369233 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    REM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTCTTGCTT
    REM1 Expression
    About this image


    REM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Kidney (Urinary System)
             Interstitial Stroma
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Dermis (Integumentary System)
             Dermal Fibroblasts Dorsal Dermis
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
    REM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247729

    UniProtKB/Swiss-Prot: REM1_HUMAN, O75628
    Tissue specificity: Most highly expressed in the endothelial lining of the blood vessels in uterus and heart.
    Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as
    the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface
    epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the
    prostate

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for REM1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rem11 , 5 rad and gem related GTP binding protein 11, 5 85.19(n)1
    89.23(a)1
      2 (75.41 cM)5
    197001  NM_009047.51  NP_033073.11 
     1526269515 
    chicken
    (Gallus gallus)
    Aves REM11 RAS (RAD and GEM)-like GTP-binding 1 67.92(n)
    67.04(a)
      419274  XM_417447.4  XP_417447.3 
    lizard
    (Anolis carolinensis)
    Reptilia REM16
    RAS (RAD and GEM)-like GTP-binding 1
    53(a)
    1 ↔ 1
    GL344671.1(6731-20559)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rem11 RAS (RAD and GEM)-like GTP-binding 1 60.95(n)
    58.03(a)
      100124825  NM_001102791.1  NP_001096261.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rem11 rad and gem related GTP binding protein 1 64.63(n)
    62.93(a)
      394149  NM_201174.1  NP_957468.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rgk21 Rgk2 50.41(n)
    41.95(a)
      37132  NM_137498.2  NP_611342.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y52B11A.46
    Protein Y52B11A.4 (Y52B11A.4) mRNA, complete cds
    15(a)
    1 → many
    I(10979607-11004283) WBGene00013124


    ENSEMBL Gene Tree for REM1 (if available)
    TreeFam Gene Tree for REM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for REM1 gene
    RALA2  RRAS2  RALB2  ERAS2  RRAD2  NRAS2  REM22  KRAS2  
    GEM2  RRAS22  HRAS2  MRAS2  
    18 SIMAP similar genes for REM1 using alignment to 1 protein entry:     REM1_HUMAN:
    GEM    RRAD    RAP2B    RALA    RALB    RIT1
    RAP1B    RAP2A    DIRAS1    RERG    DIRAS2    RAP1A
    MRAS    RIT2    NRAS    REM2    RRAS2    RRAS

    Find genes that share paralogs with REM1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for REM1 (see all 222)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931223431,2
    --30062834(+) ACAGAA/TGTGGA 1 -- us2k10--------
    rs758026371,2
    C--30062864(+) CCAGGA/CATCCA 1 -- us2k10--------
    rs1137152781,2
    C,F--30062947(+) GCTCTG/ACACTT 1 -- us2k12Minor allele frequency- A:0.12CSA WA 119
    rs1147683491,2
    F--30063072(+) GGAGGG/AGAACT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs22338261,2
    C,F,H--30063342(+) AAAGAC/ACCCTC 1 -- int112Minor allele frequency- A:0.05NS EA NA 1764
    rs1490640591,2
    --30063542(+) AGCGCC/TAGCCG 1 -- int10--------
    rs61203871,2
    H--30063567(+) ACACAG/AGGGGC 1 -- int14Minor allele frequency- A:0.00NS EA 414
    rs22338271,2
    H--30063638(+) TACCCC/TCCTCG 1 -- int14Minor allele frequency- T:0.00NS EA 404
    rs1160663931,2
    F--30063976(+) TGGGTG/ATGCAT 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1430587851,2
    --30064191(+) GACAGC/TCAATT 1 -- ut510--------

    HapMap Linkage Disequilibrium report for REM1 (30063096 - 30072708 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for REM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458961CNV Gain19166990
    nsv470546CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing REM1
    DNA2.0 Custom Variant and Variant Library Synthesis for REM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610388    OMIM disorders: --


    Find genes that share disorders with REM1           About GenesLikeMe


    Export disorders for REM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for REM1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with REM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ges, a human GTPase of the Rad/Gem/Kir family, promotes endothelial cell sprouting and cytoskeleton reorganization. (PubMed id 10831614)1, 2, 3, 9 Pan J.Y.... Silberstein D.S. (J. Cell Biol. 2000)
    2. Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. (PubMed id 14623965)1, 3, 9 Finlin B.S....Andres D.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current. (PubMed id 16648185)1, 9 Crump S.M....Satin J. (Am. J. Physiol. Heart Circ. Physiol. 2006)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition. (PubMed id 17686775)1 Correll R.N....Andres D.A. (J. Biol. Chem. 2007)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins. (PubMed id 10441394)1 Finlin B.S. and Andres D.A. (Arch. Biochem. Biophys. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28954 HGNC: 15922 AceView: REM1 Ensembl:ENSG00000088320 euGenes: HUgn28954
    ECgene: REM1 H-InvDB: REM1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for REM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for REM1 gene:
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