REM1 Gene
protein-coding GIFtS : 49
GCID: GC20 P030063
RAS (RAD and GEM)-like GTP-binding 1 (Previous name: RAS (RAD and GEM)-like GTP-binding ) (Previous symbol: REM )
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Aliasesfor REM1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases RAS (RAD And GEM)-Like GTP-Binding 1 1 2 RAS (RAD And GEM)-Like GTP-Binding1 GES1 2 3 GD:REM2 REM1 2 3 GTP-Binding Protein REM 12 Rad And Gem-Like GTP-Binding Protein 12 3 GTPase GES2 GTPase-Regulating Endothelial Cell Sprouting2 3
Export aliases for REM1 gene to outside databases Previous GC identifers: GC20P030809 GC20P029526 GC20P026851
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Summariesfor REM1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for REM1 : The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: REM1_HUMAN, O75628 Function : Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis.May function in Ca(2+) signaling
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Genomic Viewsfor REM1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000020.10 NC_018931.1 NT_011362.10 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the REM1 gene promoter: Elk-1 AML1a AP-1 ATF-2 Evi-1 HEN1 Meis-1a c-Jun Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for REM1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REM1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.21 REM1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20P030063: view genomic region
(about GC identifiers )
Start:
30,063,096 bp from pter
End:
30,072,708 bp from pter
Size:
9,613 bases
Orientation:
plus strand
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Proteinsfor REM1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: REM1_HUMAN, O75628 (See
protein sequence )Recommended Name: GTP-binding protein REM 1 Size : 298 amino acids; 32947 Da
Subunit : In vitro, interacts with calmodulin in a calcium-dependent manner
1 PDB 3D structure from and Proteopedia for REM1 :2NZJ (3D)
 
Secondary accessions : E1P5L1 Q5TZR7 Q5TZR8 Q9NP57Explore the universe of human proteins at neXtProt for REM1: NX_O75628 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O75628 REM1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_054731.2 ENSEMBL proteins: ENSP00000201979 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016020 membrane
IEA --
REM1 for ontologies About GeneDecksing REM1 Antibody Products: Assay Products for REM1:
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Protein
Domains / Familiesfor REM1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
REM1 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O75628 ProtoNet protein and cluster: O75628
UniProtKB/Swiss-Prot: REM1_HUMAN, O75628 Similarity : Belongs to the small GTPase superfamily. RGK family
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Functionfor REM1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: REM1_HUMAN, O75628 Function : Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis.May function in Ca(2+) signaling
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for REM1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for REM1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): REM1 (NM_013372 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for REM1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat REM1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REM1
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
REM1 for ontologies About GeneDecksing
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Pathways & Interactionsfor REM1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for REM1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)5/7 Interacting proteins for REM1 (O75628 3 ENSP00000201979 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 7 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007264 small GTPase mediated signal transduction
IEA --
REM1 for ontologies About GeneDecksing
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Drugs & Compoundsfor REM1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
REM1 for compounds About GeneDecksing Browse Tocris compounds for REM1 1 HMDB Compound for REM1 About this table 2 Novoseek chemical compound relationships for REM1 gene About this table
Search CenterWatch for drugs/clinical trials and news about REM1
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Transcriptsfor REM1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for REM1 gene: NM_014012.4 Unigene Cluster for REM1:
RAS (RAD and GEM)-like GTP-binding 1 Hs.247729 [show with all ESTs ] Unigene Representative Sequence: BC039813 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000201979 (uc002wwa.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for REM1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for REM1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): REM1 (NM_013372 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for REM1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat REM1
Additional cDNA sequence: AF084465.1 AF152863.1 AK313060.1 BC039813.1 BT020078.1 BT020079.1
1 DOTS entry : DT.206043
24/29 AceView cDNA sequences (see all 29 ):
AI432309 CR598485 BC039813 AI335904 CA418563 CR626669 NM_014012 AF152863 BI521371 BU681782 AF084465 BX369234 BQ879420 BF979509 AI088453 AL546961 BF980129 AA232755 AW263945 AI191821 AI984048 AA977571 AA232125 BI772170 GeneLoc Exon Structure
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Expression for REM1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section REM1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGTCTTGCTT
About this image REM1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Kidney Interstitial Stroma Kidney Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See REM1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for REM1 SOURCE GeneReport for Unigene cluster: Hs.247729 UniProtKB/Swiss-Prot: REM1_HUMAN, O75628 Tissue specificity : Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lowerlevels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate SABiosciences Custom PCR Arrays for REM1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for REM1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat REM1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat REM1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat REM1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REM1
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Orthologsfor REM1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for REM1 gene from 5/19 species (see all 19 ) About this table
ENSEMBL Gene Tree for REM1 (if available)TreeFam Gene Tree for REM1 (if available)
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Paralogsfor REM1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for REM1 gene RALA 2 RIT2 2 RIT1 2 RRAS 2 ERAS 2 RALB 2 NRAS 2 RRAD 2 REM2 2 KRAS 2 GEM 2 RRAS2 2 HRAS 2 MRAS 2 18 SIMAP similar genes for REM1 using alignment to 1 protein entry: REM1_HUMAN :GEM RRAD RAP2B RALA RALB RIT1 RAP1B RAP2A DIRAS1 RERG DIRAS2 RAP1A MRAS RIT2 NRAS REM2 RRAS2 RRAS
REM1 for paralogs About GeneDecksing
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Genomic Variantsfor REM1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 20 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for REM1 (30063096 - 30072708 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for REM1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing REM1
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Disorders
/ Diseasesfor REM1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
REM1 for disorders About GeneDecksing
OMIM gene information: 610388
OMIM disorders : --4 diseases for REM1 : About MalaCards female breast cancer gastroparesis breast cancer prostatitis Export disorders for REM1 gene to outside databases
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Publicationsfor REM1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for REM1 gene, integrated from 9 sources (see all 17 ): (articles sorted by number of sources associating them with REM1) Utopia : connect your pdf to the dynamic world of online information
Ges, a human GTPase of the Rad/Gem/Kir family, promotes endothelial cell sprouting and cytoskeleton reorganization. (PubMed id 10831614) 1 , 2 , 3, 9 Pan J.Y.... Silberstein D.S. (2000) Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. (PubMed id 14623965) 1 , 3, 9 Finlin B.S....Andres D.A. (2003) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052) 1 , 2 Deloukas P....Rogers J. (2001) L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current. (PubMed id 16648185) 1 , 9 Crump S.M....Satin J. (2006) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition. (PubMed id 17686775) 1 Correll R.N....Andres D.A. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for REM1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing REM1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing REM1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing REM1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for REM1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for REM1 gene: Search GeneIP for patents involving REM1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor REM1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for REM1 OriGene shRNA RFP for REM1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for REM1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for REM1 OriGene Protein Over-expression Lysate for REM1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for REM1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for REM1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for REM1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for REM1 OriGene Custom Protein Services for REM1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat REM1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing REM1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REM1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat REM1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat REM1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat REM1
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REM1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REM1
ThermoFisher Antibodies for REM1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat REM1
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Aliases for REM1
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Disorders / Diseases for REM1
Domains / Families for REM1
Drugs / Compounds for REM1
Expression for REM1
Function for REM1
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Orthologs for REM1
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