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Aliases for REM1 Gene

Aliases for REM1 Gene

  • RAS (RAD And GEM)-Like GTP-Binding 1 2 3
  • GES 3 4 6
  • GTPase-Regulating Endothelial Cell Sprouting 3 4
  • Rad And Gem-Like GTP-Binding Protein 1 4
  • RAS (RAD And GEM)-Like GTP-Binding 2
  • GTP-Binding Protein REM 1 3
  • GTPase GES 2
  • GD:REM 3
  • REM 4

External Ids for REM1 Gene

Previous HGNC Symbols for REM1 Gene

  • REM

Previous GeneCards Identifiers for REM1 Gene

  • GC20P030809
  • GC20P029526
  • GC20P030063
  • GC20P026851

Summaries for REM1 Gene

Entrez Gene Summary for REM1 Gene

  • The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for REM1 Gene

REM1 (RAS (RAD And GEM)-Like GTP-Binding 1) is a Protein Coding gene. GO annotations related to this gene include GTP binding and calmodulin binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for REM1 Gene

  • Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REM1 Gene

Genomics for REM1 Gene

Regulatory Elements for REM1 Gene

Genomic Location for REM1 Gene

31,475,288 bp from pter
31,484,905 bp from pter
9,618 bases
Plus strand

Genomic View for REM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REM1 Gene

Proteins for REM1 Gene

  • Protein details for REM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein REM 1
    Protein Accession:
    Secondary Accessions:
    • E1P5L1
    • Q5TZR7
    • Q5TZR8
    • Q9NP57

    Protein attributes for REM1 Gene

    298 amino acids
    Molecular mass:
    32947 Da
    Quaternary structure:
    • In vitro, interacts with calmodulin in a calcium-dependent manner

    Three dimensional structures from OCA and Proteopedia for REM1 Gene

neXtProt entry for REM1 Gene

Proteomics data for REM1 Gene at MOPED

Post-translational modifications for REM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for REM1 Gene

Domains for REM1 Gene

Suggested Antigen Peptide Sequences for REM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O75628
  • Belongs to the small GTPase superfamily. RGK family.
genes like me logo Genes that share domains with REM1: view

No data available for Gene Families for REM1 Gene

Function for REM1 Gene

Molecular function for REM1 Gene

UniProtKB/Swiss-Prot Function: Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling

Gene Ontology (GO) - Molecular Function for REM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IEA --
GO:0005525 GTP binding IEA --
GO:0015093 ferrous iron transmembrane transporter activity --
genes like me logo Genes that share ontologies with REM1: view

Animal Model Products

CRISPR Products

miRNA for REM1 Gene

miRTarBase miRNAs that target REM1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for REM1 Gene

Localization for REM1 Gene

Subcellular locations from

Jensen Localization Image for REM1 Gene COMPARTMENTS Subcellular localization image for REM1 gene
Compartment Confidence
cytosol 3
nucleus 3
golgi apparatus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for REM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with REM1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for REM1 Gene

Pathways for REM1 Gene

SuperPathways for REM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport --
GO:0015684 ferrous iron transport --
genes like me logo Genes that share ontologies with REM1: view

No data available for Pathways by source for REM1 Gene

Compounds for REM1 Gene

(1) HMDB Compounds for REM1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(2) Novoseek inferred chemical compound relationships for REM1 Gene

Compound -log(P) Hits PubMed IDs
guanylate 48.7 1
calcium 41.9 11
genes like me logo Genes that share compounds with REM1: view

Transcripts for REM1 Gene

mRNA/cDNA for REM1 Gene

Unigene Clusters for REM1 Gene

RAS (RAD and GEM)-like GTP-binding 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REM1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REM1 Gene

No ASD Table

Relevant External Links for REM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REM1 Gene

mRNA expression in normal human tissues for REM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for REM1 Gene

SOURCE GeneReport for Unigene cluster for REM1 Gene Hs.247729

mRNA Expression by UniProt/SwissProt for REM1 Gene

Tissue specificity: Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate
genes like me logo Genes that share expressions with REM1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for REM1 Gene

Orthologs for REM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for REM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia REM1 35
  • 99.55 (n)
  • 99.66 (a)
REM1 36
  • 100 (a)
(Bos Taurus)
Mammalia REM1 35
  • 87.92 (n)
  • 92.28 (a)
REM1 36
  • 92 (a)
(Canis familiaris)
Mammalia REM1 35
  • 89.37 (n)
  • 91.95 (a)
REM1 36
  • 76 (a)
(Mus musculus)
Mammalia Rem1 35
  • 85.19 (n)
  • 89.23 (a)
Rem1 16
Rem1 36
  • 89 (a)
(Monodelphis domestica)
Mammalia REM1 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
(Rattus norvegicus)
Mammalia Rem1 35
  • 87.09 (n)
  • 90.57 (a)
(Gallus gallus)
Aves REM1 35
  • 67.92 (n)
  • 67.04 (a)
REM1 36
  • 52 (a)
(Anolis carolinensis)
Reptilia REM1 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rem1 35
  • 60.95 (n)
  • 58.03 (a)
(Danio rerio)
Actinopterygii rem1 35
  • 64.63 (n)
  • 62.93 (a)
rem1 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007615 35
  • 47.9 (n)
  • 39.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42541 36
  • 7 (a)
Rgk1 36
  • 19 (a)
Rgk2 35
  • 50.41 (n)
  • 41.95 (a)
Rgk2 36
  • 13 (a)
Rgk3 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea Y52B11A.4 36
  • 15 (a)
Species with no ortholog for REM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REM1 Gene

Gene Tree for REM1 (if available)
Gene Tree for REM1 (if available)

Paralogs for REM1 Gene

Paralogs for REM1 Gene

Selected SIMAP similar genes for REM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with REM1: view

Variants for REM1 Gene

Sequence variations from dbSNP and Humsavar for REM1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs215911 -- 31,479,520(+) CTTTC(A/G)CCTTG intron-variant
rs717064 -- 31,478,553(-) CAAAC(A/C)AGATA intron-variant
rs752841 -- 31,479,511(+) CCCAG(C/T)TTGCT intron-variant
rs1006459 - 31,476,528(+) GGGCC(A/C/G)CCAGC reference, missense
rs1406919 -- 31,477,375(+) ACATA(G/T)GGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REM1 Gene

Variant ID Type Subtype PubMed ID
nsv470546 CNV Gain 18288195
nsv458961 CNV Gain 19166990

Relevant External Links for REM1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REM1 Gene

Disorders for REM1 Gene

No disorders were found for REM1 Gene.

No data available for UniProtKB/Swiss-Prot for REM1 Gene

Publications for REM1 Gene

  1. Ges, a human GTPase of the Rad/Gem/Kir family, promotes endothelial cell sprouting and cytoskeleton reorganization. (PMID: 10831614) Pan J.Y. … Silberstein D.S. (J. Cell Biol. 2000) 2 3 4 23
  2. Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. (PMID: 14623965) Finlin B.S. … Andres D.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 23
  3. L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current. (PMID: 16648185) Crump S.M. … Satin J. (Am. J. Physiol. Heart Circ. Physiol. 2006) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for REM1 Gene

  • Addgene plasmids for REM1

Sources for REM1 Gene

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