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Aliases for REM1 Gene

Aliases for REM1 Gene

  • RRAD And GEM Like GTPase 1 2 3 5
  • GTPase-Regulating Endothelial Cell Sprouting 3 4
  • GES 3 4
  • Rad And Gem-Like GTP-Binding Protein 1 4
  • RAS (RAD And GEM)-Like GTP-Binding 1 3
  • RAS (RAD And GEM)-Like GTP-Binding 2
  • GTP-Binding Protein REM 1 3
  • GTPase GES 2
  • GD:REM 3
  • REM 4

External Ids for REM1 Gene

Previous HGNC Symbols for REM1 Gene

  • REM

Previous GeneCards Identifiers for REM1 Gene

  • GC20P030809
  • GC20P029526
  • GC20P030063
  • GC20P026851

Summaries for REM1 Gene

Entrez Gene Summary for REM1 Gene

  • The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for REM1 Gene

REM1 (RRAD And GEM Like GTPase 1) is a Protein Coding gene. Diseases associated with REM1 include Epileptic Encephalopathy, Childhood-Onset and Nominal Aphasia. Gene Ontology (GO) annotations related to this gene include GTP binding and ferrous iron transmembrane transporter activity. An important paralog of this gene is RRAD.

UniProtKB/Swiss-Prot for REM1 Gene

  • Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling.

Additional gene information for REM1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REM1 Gene

Genomics for REM1 Gene

GeneHancer (GH) Regulatory Elements for REM1 Gene

Promoters and enhancers for REM1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I031474 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 550.8 +0.2 168 1.4 PKNOX1 CREB1 ZNF24 FOS PRDM4 EZH2 DEFB124 REM1 DEFB123
GH20I031475 Enhancer 0.3 Ensembl 550.8 -1.2 -1187 0.2 ATF4 REM1 DEFB124 GC20M031466
GH20I031513 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 +40.7 40695 4.3 HDGF SMAD1 FOXA2 MLX ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 HM13 DEFB124 ASXL1 REM1 ENSG00000274364
GH20I031840 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 15.3 +368.7 368747 6.6 HDGF PKNOX1 SIN3A YBX1 ZNF48 TCF12 GLIS2 ZNF207 ZNF143 ATF7 FOXS1 GC20M031845 ASXL1 MYLK2 POFUT1 TSPY26P TTLL9 TM9SF4 BAK1P1 PLAGL2
GH20I032108 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 +636.1 636119 5 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 TM9SF4 RSL24D1P6 HCK COX4I2 FOXS1 REM1 PLAGL2 TSPY26P MYLK2 NOL4L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around REM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the REM1 gene promoter:

Genomic Locations for REM1 Gene

Genomic Locations for REM1 Gene
9,618 bases
Plus strand

Genomic View for REM1 Gene

Genes around REM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REM1 Gene

Proteins for REM1 Gene

  • Protein details for REM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein REM 1
    Protein Accession:
    Secondary Accessions:
    • E1P5L1
    • Q5TZR7
    • Q5TZR8
    • Q9NP57

    Protein attributes for REM1 Gene

    298 amino acids
    Molecular mass:
    32947 Da
    Quaternary structure:
    • In vitro, interacts with calmodulin in a calcium-dependent manner.

    Three dimensional structures from OCA and Proteopedia for REM1 Gene

neXtProt entry for REM1 Gene

Post-translational modifications for REM1 Gene

No Post-translational modifications

Other Protein References for REM1 Gene

No data available for DME Specific Peptides for REM1 Gene

Domains & Families for REM1 Gene

Gene Families for REM1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for REM1 Gene

Suggested Antigen Peptide Sequences for REM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. RGK family.
  • Belongs to the small GTPase superfamily. RGK family.
genes like me logo Genes that share domains with REM1: view

Function for REM1 Gene

Molecular function for REM1 Gene

UniProtKB/Swiss-Prot Function:
Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling.

Phenotypes From GWAS Catalog for REM1 Gene

Gene Ontology (GO) - Molecular Function for REM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005516 calmodulin binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with REM1: view

Phenotypes for REM1 Gene

GenomeRNAi human phenotypes for REM1:
genes like me logo Genes that share phenotypes with REM1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for REM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REM1 Gene

Localization for REM1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REM1 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for REM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with REM1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for REM1 Gene

Pathways & Interactions for REM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:1901842 negative regulation of high voltage-gated calcium channel activity IEA --
genes like me logo Genes that share ontologies with REM1: view

No data available for Pathways by source and SIGNOR curated interactions for REM1 Gene

Drugs & Compounds for REM1 Gene

(1) Drugs for REM1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(1) Additional Compounds for REM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with REM1: view

Transcripts for REM1 Gene

mRNA/cDNA for REM1 Gene

Unigene Clusters for REM1 Gene

RAS (RAD and GEM)-like GTP-binding 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for REM1

Alternative Splicing Database (ASD) splice patterns (SP) for REM1 Gene

No ASD Table

Relevant External Links for REM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for REM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for REM1 Gene

This gene is overexpressed in Pancreatic juice (25.7), Uterus (24.0), and Heart (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for REM1 Gene

Protein tissue co-expression partners for REM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of REM1 Gene:


SOURCE GeneReport for Unigene cluster for REM1 Gene:


mRNA Expression by UniProt/SwissProt for REM1 Gene:

Tissue specificity: Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate.

Evidence on tissue expression from TISSUES for REM1 Gene

  • Nervous system(4.4)
  • Lymph node(4.3)
  • Stomach(3.2)
genes like me logo Genes that share expression patterns with REM1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for REM1 Gene

Orthologs for REM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for REM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia REM1 33 34
  • 99.55 (n)
(Canis familiaris)
Mammalia REM1 33 34
  • 89.37 (n)
(Bos Taurus)
Mammalia REM1 33 34
  • 87.92 (n)
(Rattus norvegicus)
Mammalia Rem1 33
  • 87.09 (n)
(Mus musculus)
Mammalia Rem1 33 16 34
  • 85.19 (n)
(Monodelphis domestica)
Mammalia REM1 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 39 (a)
(Gallus gallus)
Aves REM1 33 34
  • 67.92 (n)
(Anolis carolinensis)
Reptilia REM1 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rem1 33
  • 60.95 (n)
(Danio rerio)
Actinopterygii rem1 33 34
  • 64.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rgk2 33 34
  • 50.41 (n)
Rgk1 34
  • 19 (a)
Rgk3 34
  • 19 (a)
CG42541 34
  • 7 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007615 33
  • 47.9 (n)
(Caenorhabditis elegans)
Secernentea Y52B11A.4 34
  • 15 (a)
Species where no ortholog for REM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REM1 Gene

Gene Tree for REM1 (if available)
Gene Tree for REM1 (if available)

Paralogs for REM1 Gene

Paralogs for REM1 Gene

(18) SIMAP similar genes for REM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with REM1: view

Variants for REM1 Gene

Sequence variations from dbSNP and Humsavar for REM1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs550409143 likely-benign, Long QT syndrome 31,482,440(+) G/A coding_sequence_variant, missense_variant
rs1000377779 -- 31,480,571(+) C/A intron_variant
rs1000433540 -- 31,474,165(+) T/C upstream_transcript_variant
rs1000656023 -- 31,480,202(+) G/C intron_variant
rs1000921203 -- 31,479,990(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for REM1 Gene

Variant ID Type Subtype PubMed ID
dgv4300n100 CNV gain 25217958
esv2763228 CNV gain 21179565
nsv458961 CNV gain 19166990
nsv470546 CNV gain 18288195
nsv585911 CNV gain 21841781

Variation tolerance for REM1 Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.39; 92.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REM1 Gene

Disorders for REM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for REM1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
epileptic encephalopathy, childhood-onset
  • eeoc
nominal aphasia
  • anomia
- elite association - COSMIC cancer census association via MalaCards
Search REM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for REM1

genes like me logo Genes that share disorders with REM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REM1 Gene

Publications for REM1 Gene

  1. Ges, A human GTPase of the Rad/Gem/Kir family, promotes endothelial cell sprouting and cytoskeleton reorganization. (PMID: 10831614) Pan JY … Silberstein DS (The Journal of cell biology 2000) 2 3 4 22 58
  2. Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. (PMID: 14623965) Finlin BS … Andres DA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 22 58
  3. Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. (PMID: 22076634) Jhun BS … Jin ZG (Circulation research 2012) 2 3 58
  4. L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current. (PMID: 16648185) Crump SM … Satin J (American journal of physiology. Heart and circulatory physiology 2006) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for REM1 Gene

  • Addgene plasmids for REM1

Sources for REM1 Gene

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