Aliases for RELT Gene
External Ids for RELT Gene
Previous HGNC Symbols for RELT Gene
Previous GeneCards Identifiers for RELT Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for RELT Gene
RELT (RELT Tumor Necrosis Factor Receptor) is a Protein Coding gene. Among its related pathways are TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions and TRAF Pathway. An important paralog of this gene is RELL1.
UniProtKB/Swiss-Prot for RELT Gene
Mediates activation of NF-kappa-B. May play a role in T-cell activation.