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Aliases for RELT Gene

Aliases for RELT Gene

  • RELT, TNF Receptor 2 3 5
  • Receptor Expressed In Lymphoid Tissues 2 3 4
  • RELT Tumor Necrosis Factor Receptor 2 3
  • TNFRSF19L 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 19-Like 2
  • Tumor Necrosis Factor Receptor Superfamily Member 19L 3
  • TRLT 3

External Ids for RELT Gene

Previous HGNC Symbols for RELT Gene


Previous GeneCards Identifiers for RELT Gene

  • GC11P072766
  • GC11P073087
  • GC11P069382

Summaries for RELT Gene

Entrez Gene Summary for RELT Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RELT Gene

RELT (RELT, TNF Receptor) is a Protein Coding gene. Among its related pathways are TRAF Pathway and TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions. An important paralog of this gene is RELL1.

UniProtKB/Swiss-Prot for RELT Gene

  • Mediates activation of NF-kappa-B. May play a role in T-cell activation.

Gene Wiki entry for RELT Gene

Additional gene information for RELT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RELT Gene

Genomics for RELT Gene

Regulatory Elements for RELT Gene

Enhancers for RELT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H073414 1.3 FANTOM5 Ensembl ENCODE dbSUPER 20.7 +38.7 38732 2 CTBP1 IKZF1 RUNX3 SP7 RELT FAM168A ARHGEF17 ENSG00000255928 PIR54238 PIR45238
GH11H073268 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.9 -104.2 -104218 7.7 FOXA2 ARID4B SIN3A SCRT2 FOS RCOR1 IKZF2 SMARCA5 SMARCC1 ELF1 RELT FCHSD2 ENSG00000215841 P2RY2 ARHGEF17 P2RY6
GH11H073375 1.8 FANTOM5 ENCODE dbSUPER 12.4 +6.5 6534 15 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF416 ENSG00000206913 C2CD3 ARPC3P4 P4HA3 ARHGEF17 LOC105369379 ENSG00000256448 RELT CLPB P4HA3-AS1
GH11H073319 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -52.4 -52362 8.7 PKNOX1 ARID4B GLIS2 ZNF143 FOS ATF7 RUNX3 SP5 JUNB ZNF623 ARHGEF17 RELT P2RY6 FAM168A PIR46387 PIR54825
GH11H073307 1.6 Ensembl ENCODE dbSUPER 12 -63.5 -63457 12.5 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ARHGEF17 RELT FAM168A PAAF1 ENSG00000257038 GC11M073312
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RELT on UCSC Golden Path with GeneCards custom track

Promoters for RELT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for RELT Gene

Genomic Locations for RELT Gene
21,211 bases
Plus strand

Genomic View for RELT Gene

Genes around RELT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RELT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RELT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RELT Gene

Proteins for RELT Gene

  • Protein details for RELT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 19L
    Protein Accession:
    Secondary Accessions:
    • Q86V34
    • Q96JU1
    • Q9BUX7

    Protein attributes for RELT Gene

    430 amino acids
    Molecular mass:
    46092 Da
    Quaternary structure:
    • Associates with TRAF1. Interacts with RELL1, RELL2 and OXSR1.
    • Sequence=BAB84954.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for RELT Gene

Post-translational modifications for RELT Gene

Other Protein References for RELT Gene

Antibody Products

  • R&D Systems Antibodies for RELT (RELT/TNFRSF19L)
  • Santa Cruz Biotechnology (SCBT) Antibodies for RELT

No data available for DME Specific Peptides for RELT Gene

Domains & Families for RELT Gene

Gene Families for RELT Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for RELT Gene

Suggested Antigen Peptide Sequences for RELT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RELT family.
  • Belongs to the RELT family.
genes like me logo Genes that share domains with RELT: view

Function for RELT Gene

Molecular function for RELT Gene

UniProtKB/Swiss-Prot Function:
Mediates activation of NF-kappa-B. May play a role in T-cell activation.

Phenotypes From GWAS Catalog for RELT Gene

Gene Ontology (GO) - Molecular Function for RELT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
genes like me logo Genes that share ontologies with RELT: view
genes like me logo Genes that share phenotypes with RELT: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RELT Gene

Localization for RELT Gene

Subcellular locations from UniProtKB/Swiss-Prot for RELT Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RELT gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 2
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RELT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RELT: view

Pathways & Interactions for RELT Gene

genes like me logo Genes that share pathways with RELT: view

Pathways by source for RELT Gene

Gene Ontology (GO) - Biological Process for RELT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007275 multicellular organism development IBA --
GO:0032496 response to lipopolysaccharide IBA --
GO:0033209 tumor necrosis factor-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with RELT: view

No data available for SIGNOR curated interactions for RELT Gene

Drugs & Compounds for RELT Gene

No Compound Related Data Available

Transcripts for RELT Gene

Unigene Clusters for RELT Gene

RELT tumor necrosis factor receptor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RELT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: - - - - - - -
SP8: - - - - - - -

Relevant External Links for RELT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RELT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RELT Gene

mRNA differential expression in normal tissues according to GTEx for RELT Gene

This gene is overexpressed in Whole Blood (x18.9).

Protein differential expression in normal tissues from HIPED for RELT Gene

This gene is overexpressed in Urine (62.1) and Heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RELT Gene

Protein tissue co-expression partners for RELT Gene

NURSA nuclear receptor signaling pathways regulating expression of RELT Gene:


SOURCE GeneReport for Unigene cluster for RELT Gene:


mRNA Expression by UniProt/SwissProt for RELT Gene:

Tissue specificity: Highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas.

Evidence on tissue expression from TISSUES for RELT Gene

  • Blood(4.2)
  • Intestine(4.2)
  • Spleen(4.2)
  • Eye(4)
  • Nervous system(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with RELT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RELT Gene

Orthologs for RELT Gene

This gene was present in the common ancestor of chordates.

Orthologs for RELT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RELT 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia RELT 33 34
  • 86.26 (n)
(Bos Taurus)
Mammalia RELT 33 34
  • 84.88 (n)
(Mus musculus)
Mammalia Relt 33 16 34
  • 84.54 (n)
(Rattus norvegicus)
Mammalia Relt 33
  • 83.37 (n)
(Monodelphis domestica)
Mammalia RELT 34
  • 63 (a)
(Gallus gallus)
Aves RELT 33 34
  • 61.81 (n)
(Anolis carolinensis)
Reptilia RELT 34
  • 53 (a)
(Danio rerio)
Actinopterygii relt 33 34
  • 55.62 (n)
Species where no ortholog for RELT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RELT Gene

Gene Tree for RELT (if available)
Gene Tree for RELT (if available)

Paralogs for RELT Gene

Paralogs for RELT Gene

genes like me logo Genes that share paralogs with RELT: view

Variants for RELT Gene

Sequence variations from dbSNP and Humsavar for RELT Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000014553 -- 73,388,185(+) TCCCA(-/CT)CTGCT intron-variant, upstream-variant-2KB
rs1000071005 -- 73,388,954(+) GCCTG(C/T)GCTTG intron-variant, upstream-variant-2KB
rs1000490926 -- 73,389,020(+) CCCCA(C/T)GAGTC intron-variant, upstream-variant-2KB
rs1000559906 -- 73,393,353(+) ATCAT(C/T)GTGGC intron-variant, utr-variant-5-prime
rs1000633559 -- 73,393,024(+) CCCCT(G/T)CAGGG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RELT Gene

Variant ID Type Subtype PubMed ID
nsv951041 CNV deletion 24416366
nsv832208 CNV gain 17160897
nsv825993 CNV gain 20364138
nsv1126300 CNV deletion 24896259

Variation tolerance for RELT Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RELT Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RELT Gene

Disorders for RELT Gene

Relevant External Links for RELT

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RELT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RELT Gene

Publications for RELT Gene

  1. RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB. (PMID: 11313261) Sica GL … Chen L (Blood 2001) 2 3 4 22 60
  2. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. (PMID: 16389068) Cusick JK … Shu HB (Biochemical and biophysical research communications 2006) 2 3 4 60
  3. Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. (PMID: 16547002) Bossen C … Schneider P (The Journal of biological chemistry 2006) 2 3 60
  4. TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis. (PMID: 16950202) Polek TC … Spivak-Kroizman TR (Biochemical and biophysical research communications 2006) 2 3 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for RELT Gene

Sources for RELT Gene

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