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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RELT Gene

protein-coding   GIFtS: 57
GCID: GC11P073087

RELT Tumor Necrosis Factor Receptor

(Previous names: tumor necrosis factor receptor superfamily, member 19-like)
(Previous symbol: TNFRSF19L)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RELT Tumor Necrosis Factor Receptor1 2
TNFRSF19L1 2 3 5
Receptor Expressed In Lymphoid Tissues2 3
Tumor Necrosis Factor Receptor Superfamily, Member 19-Like1
TRLT2
Tumor Necrosis Factor Receptor Superfamily Member 19L2

External Ids:    HGNC: 137641   Entrez Gene: 849572   Ensembl: ENSG000000549677   OMIM: 6112115   UniProtKB: Q969Z43   

Export aliases for RELT gene to outside databases

Previous GC identifers: GC11P072766 GC11P069382


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RELT Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant
in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF
receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the
presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced
transcript variants of this gene encoding the same protein have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for RELT Gene: 
RELT (RELT tumor necrosis factor receptor) is a protein-coding gene. Diseases associated with RELT include liver disease, and among its related super-pathways are TNF Signaling and STAT3 Pathway. An important paralog of this gene is RELL1.

UniProtKB/Swiss-Prot: TR19L_HUMAN, Q969Z4
Function: Mediates activation of NF-kappa-B. May play a role in T-cell activation

Gene Wiki entry for RELT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RELT gene promoter:
         NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RELT promoter sequence
   Search SABiosciences Chromatin IP Primers for RELT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RELT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.2

RELT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RELT gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P073087:  view genomic region     (about GC identifiers)

Start:
73,087,309 bp from pter      End:
73,108,519 bp from pter
Size:
21,211 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TR19L_HUMAN, Q969Z4 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 19L precursor  
Size: 430 amino acids; 46092 Da
Subunit: Associates with TRAF1. Interacts with RELL1, RELL2 and OXSR1
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cytoplasm
Sequence caution: Sequence=BAB84954.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q86V34 Q96JU1 Q9BUX7

Explore the universe of human proteins at neXtProt for RELT: NX_Q969Z4

Explore proteomics data for RELT at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated in vitro by OXSR1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969Z4

  • RELT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RELT Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_116260.2  NP_689408.1  

    ENSEMBL proteins: 
     ENSP00000064780   ENSP00000439352   ENSP00000440562   ENSP00000377207  

    Human Recombinant Protein Products for RELT: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RELT
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RELT
    GenScript Custom Purified and Recombinant Proteins Services for RELT
    Novus Biologicals RELT Proteins
    Novus Biologicals RELT Lysates
    Sino Biological Recombinant Protein for RELT
    Sino Biological Cell Lysate for RELT 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    RELT for ontologies           About GeneDecksing



    RELT Antibody Products: 
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    Assay Products for RELT: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: RELT 
    Tumour necrosis factor (TNF) receptor family

    3 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR022333 TNFR_19-like
     IPR022248 TNF_rcpt_RELT

    Graphical View of Domain Structure for InterPro Entry Q969Z4

    ProtoNet protein and cluster: Q969Z4

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TR19L_HUMAN, Q969Z4
    Similarity: Belongs to the RELT family
    Similarity: Contains 1 TNFR-Cys repeat


    RELT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TR19L_HUMAN, Q969Z4
    Function: Mediates activation of NF-kappa-B. May play a role in T-cell activation

    Phenotypes:
         1 GenomeRNAi human phenotype for RELT:

     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RELT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RELT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RELT 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RELT 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RELT
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate RELT (see all 35):
    hsa-miR-194* hsa-miR-4272 hsa-miR-15a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-486-3p hsa-miR-449a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidRELT 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RELT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RELT

    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RELT (NM_152222)
    Sino Biological Human cDNA Clone for RELT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RELT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELT
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                         Customized lentivirus expression plasmids for stable overexpression of RELT 

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    Search LifeMap BioReagents cell lines for RELT
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RELT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RELT
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions


    3 Sino Biological Pathways for RELT 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1         Kegg Pathway  (Kegg details for RELT):
        Cytokine-cytokine receptor interaction


    RELT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RELT

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RELT (Q969Z43 ENSP000000647804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELL1Q8IUW53, ENSP000003133854I2D: score=1 STRING: ENSP00000313385
    STK39Q9UEW83, ENSP000003482784I2D: score=1 STRING: ENSP00000348278
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RELT (TR19L)

    Search CenterWatch for drugs/clinical trials and news about RELT / TR19L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RELT gene (2 alternative transcripts): 
    NM_032871.3  NM_152222.1  

    Unigene Cluster for RELT:

    RELT tumor necrosis factor receptor
    Hs.533720  [show with all ESTs]
    Unigene Representative Sequence: NM_032871
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000064780(uc001otv.3 uc001otw.3) ENST00000545687 ENST00000544075
    ENST00000393580(uc009yto.1) ENST00000545886 ENST00000539134(uc001otx.3)
    ENST00000537771
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RELT
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate RELT (see all 35):
    hsa-miR-194* hsa-miR-4272 hsa-miR-15a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-486-3p hsa-miR-449a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidRELT 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RELT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RELT
    Clone
    Products:
         
    OriGene clones in human, mouse for RELT (see all 13)
    OriGene ORF clones in mouse, rat for RELT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RELT (NM_152222)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RELT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELT
    Sirion Biotech Customized lentivirus for stable overexpression of RELT 
                         Customized lentivirus expression plasmids for stable overexpression of RELT 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RELT
    OriGene qSTAR qPCR primer pairs in human, mouse for RELT
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RELT
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RELT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RELT

    Additional mRNA sequence: 

    AK027899.1 AK310103.1 BC001812.2 BC017279.2 BC051810.1 

    6 DOTS entries:

    DT.409723  DT.100026258  DT.97858758  DT.95081124  DT.120690506  DT.91861349 

    24/102 AceView cDNA sequences (see all 102):

    BQ679844 AI949593 AI364803 AW450817 NM_152222 BM809499 BQ220894 AW276243 
    BM695388 AA251791 AK074128 BX102739 AI357545 CD370879 BC051810 AI523987 
    NM_032871 BM708834 BQ682129 AK057036 CA447259 AI570540 BI824208 BM544538 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RELT (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                    -     -     -     -                                         -                       -     -                                 
    SP2:                          -     -     -                                         -                       -     -                                 
    SP3:                                                                                -                                                               
    SP4:                    -                 -                                                                                                         
    SP5:                    -     -     -     -                 -     -                 -                                                               


    ECgene alternative splicing isoforms for RELT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RELT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTGAATAA
    RELT Expression
    About this image


    See RELT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RELT

    SOURCE GeneReport for Unigene cluster: Hs.533720

    UniProtKB/Swiss-Prot: TR19L_HUMAN, Q969Z4
    Tissue specificity: Highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and
    fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including RELT: 
              TNF Ligands & Receptors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RELT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RELT gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Relt1 , 5 RELT tumor necrosis factor receptor1, 5 84.54(n)1
    86.01(a)1
      7 (54.44 cM)5
    3201001  NM_177073.61  NP_796047.21 
     1008458485 
    chicken
    (Gallus gallus)
    Aves ARHGEF171 Rho guanine nucleotide exchange factor (GEF) 17 61.84(n)
    57.23(a)
      419067  XM_003640622.1  XP_003640670.1 
    lizard
    (Anolis carolinensis)
    Reptilia RELT6
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343337.1(1264908-1273999)
    zebrafish
    (Danio rerio)
    Actinopterygii relt1 RELT tumor necrosis factor receptor 55.62(n)
    50(a)
      404605  NM_207073.1  NP_996956.1 


    ENSEMBL Gene Tree for RELT (if available)
    TreeFam Gene Tree for RELT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RELT gene
    RELL12  RELL22  

    RELT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/490 SNPs in RELT are shown (see all 490)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446303381,2
    C--73085465(+) TTTCAC/GGGTCA 1 -- us2k10--------
    rs590006541,2
    F--73085565(+) TGTTTG/CGGCTG 1 -- us2k12Minor allele frequency- C:0.07CSA WA 120
    rs1871100811,2
    --73085795(+) CCCCAC/TTTAGT 2 -- us2k10--------
    rs600789071,2
    C,F--73085834(+) TCACCT/CAGGCT 2 -- us2k18Minor allele frequency- C:0.30WA NA CSA 248
    rs1159879631,2
    F--73085901(+) ATTCTC/TCCACA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1478647911,2
    --73086067(+) TGAAAC/TTGCCA 2 -- us2k10--------
    rs1922760931,2
    --73086212(+) CCAGCC/TCTGGA 2 -- us2k10--------
    rs8764801,2
    C,F,A,H--73086303(-) CATGCT/CCAGGT 2 -- us2k126Minor allele frequency- C:0.31NS EA NA WA CSA 2703
    rs1845173561,2
    --73086310(+) CATGAA/CCCAGG 2 -- us2k10--------
    rs1896174941,2
    C--73086351(+) CCATGC/TGGTGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RELT (73087309 - 73108519 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RELT:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897911CNV Loss21882294
    nsv825993CNV Gain20364138
    nsv832208CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RELT
    DNA2.0 Custom Variant and Variant Library Synthesis for RELT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611211    OMIM disorders: --

    2 diseases for RELT:    About MalaCards
    liver disease    

    1 disease from the University of Copenhagen DISEASES database for RELT:
    Liver disease

    RELT for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: RELT (1 document)

    Export disorders for RELT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RELT gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with RELT)
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    1. RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB. (PubMed id 11313261)1, 2, 3, 9 Sica G.L.... Chen L. (2001)
    2. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. (PubMed id 16389068)1, 2, 3 Cusick J.K.... Shu H.-B. (2006)
    3. Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. (PubMed id 16547002)1, 3 Bossen C....Schneider P. (2006)
    4. TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis. (PubMed id 16950202)1, 3 Polek T.C....Spivak-Kroizman T.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. RELT induces cellular death in HEK 293 epithelial cel ls. (PubMed id 19969290)1 Cusick J.K....Reyland M.E. (2010)
    9. The TNF receptor, RELT, binds SPAK and uses it to med iate p38 and JNK activation. (PubMed id 16530727)1 Polek T.C....Spivak-Kroizman T. (2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84957 HGNC: 13764 AceView: TNFRSF19L Ensembl:ENSG00000054967 euGenes: HUgn84957
    ECgene: RELT Kegg: 84957 H-InvDB: RELT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RELT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RELT gene:
    Search GeneIP for patents involving RELT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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