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Aliases for RELT Gene

Aliases for RELT Gene

  • RELT Tumor Necrosis Factor Receptor 2 3 5
  • Receptor Expressed In Lymphoid Tissues 3 4
  • TNFRSF19L 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 19-Like 2
  • Tumor Necrosis Factor Receptor Superfamily Member 19L 3
  • TRLT 3

External Ids for RELT Gene

Previous HGNC Symbols for RELT Gene


Previous GeneCards Identifiers for RELT Gene

  • GC11P072766
  • GC11P073087
  • GC11P069382

Summaries for RELT Gene

Entrez Gene Summary for RELT Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RELT Gene

RELT (RELT Tumor Necrosis Factor Receptor) is a Protein Coding gene. Among its related pathways are TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions and TRAF Pathway. An important paralog of this gene is RELL1.

UniProtKB/Swiss-Prot for RELT Gene

  • Mediates activation of NF-kappa-B. May play a role in T-cell activation.

Gene Wiki entry for RELT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RELT Gene

Genomics for RELT Gene

Regulatory Elements for RELT Gene

Enhancers for RELT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F073422 0.3 FANTOM5 22.6 +46.9 46886 0.3 RELT ARHGEF17 FAM168A PIR52508 ENSG00000255786
GH11F073413 1.5 FANTOM5 Ensembl ENCODE 20.7 +38.7 38737 2.4 PKNOX1 CBX3 MTA2 CBX5 IKZF1 SP7 TCF7L2 RELT FAM168A ARHGEF17 ENSG00000255928 PIR54238 PIR45238
GH11F073469 0.7 ENCODE 15.5 +93.9 93924 1.9 TBP PKNOX1 L3MBTL2 CEBPB MNT FEZF1 POLR2H GATA3 FOXK2 POLR3A ARHGEF17 RELT FAM168A ENSG00000255786 GC11M073483
GH11F073527 0.8 Ensembl ENCODE 15.5 +152.2 152237 1.8 DDX20 ZMYM3 ZNF175 PTRF BACH1 PYGO2 NFXL1 RELA ZFHX2 EGR2 ARHGEF17 FAM168A RELT ENSG00000255928 GC11M073518 HMGN2P38
GH11F073537 1.2 Ensembl ENCODE 15.4 +162.4 162437 3.0 PKNOX1 ESRRA BACH1 RAD21 ZNF316 CTBP1 GATA3 POLR2A FOS RCOR1 ARHGEF17 FAM168A RELT PLEKHB1 ENSG00000256448 MRPL48 ENSG00000255928 GC11M073518 HMGN2P38
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RELT on UCSC Golden Path with GeneCards custom track

Promoters for RELT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000565200 736 1601 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF416 ZNF143

Genomic Location for RELT Gene

73,376,264 bp from pter
73,397,474 bp from pter
21,211 bases
Plus strand

Genomic View for RELT Gene

Genes around RELT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RELT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RELT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RELT Gene

Proteins for RELT Gene

  • Protein details for RELT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 19L
    Protein Accession:
    Secondary Accessions:
    • Q86V34
    • Q96JU1
    • Q9BUX7

    Protein attributes for RELT Gene

    430 amino acids
    Molecular mass:
    46092 Da
    Quaternary structure:
    • Associates with TRAF1. Interacts with RELL1, RELL2 and OXSR1.
    • Sequence=BAB84954.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for RELT Gene

Post-translational modifications for RELT Gene

Other Protein References for RELT Gene

Antibody Products

  • R&D Systems Antibodies for RELT (RELT/TNFRSF19L)
  • Santa Cruz Biotechnology (SCBT) Antibodies for RELT

No data available for DME Specific Peptides for RELT Gene

Domains & Families for RELT Gene

Gene Families for RELT Gene

Protein Domains for RELT Gene

Suggested Antigen Peptide Sequences for RELT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RELT family.
  • Contains 1 TNFR-Cys repeat.
  • Belongs to the RELT family.
  • Contains 1 TNFR-Cys repeat.
genes like me logo Genes that share domains with RELT: view

Function for RELT Gene

Molecular function for RELT Gene

UniProtKB/Swiss-Prot Function:
Mediates activation of NF-kappa-B. May play a role in T-cell activation.

Gene Ontology (GO) - Molecular Function for RELT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
genes like me logo Genes that share ontologies with RELT: view
genes like me logo Genes that share phenotypes with RELT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RELT

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RELT Gene

Localization for RELT Gene

Subcellular locations from UniProtKB/Swiss-Prot for RELT Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm.

Subcellular locations from

Jensen Localization Image for RELT Gene COMPARTMENTS Subcellular localization image for RELT gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 2
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RELT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RELT: view

Pathways & Interactions for RELT Gene

genes like me logo Genes that share pathways with RELT: view

Pathways by source for RELT Gene

Gene Ontology (GO) - Biological Process for RELT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007275 multicellular organism development IBA --
GO:0032496 response to lipopolysaccharide IBA --
GO:0033209 tumor necrosis factor-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with RELT: view

No data available for SIGNOR curated interactions for RELT Gene

Transcripts for RELT Gene

Unigene Clusters for RELT Gene

RELT tumor necrosis factor receptor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RELT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: - - - - - - -
SP8: - - - - - - -

Relevant External Links for RELT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RELT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RELT Gene

mRNA differential expression in normal tissues according to GTEx for RELT Gene

This gene is overexpressed in Whole Blood (x18.9).

Protein differential expression in normal tissues from HIPED for RELT Gene

This gene is overexpressed in Urine (62.1) and Heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RELT Gene

Protein tissue co-expression partners for RELT Gene

NURSA nuclear receptor signaling pathways regulating expression of RELT Gene:


SOURCE GeneReport for Unigene cluster for RELT Gene:


mRNA Expression by UniProt/SwissProt for RELT Gene:

Tissue specificity: Highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas.
genes like me logo Genes that share expression patterns with RELT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RELT Gene

Orthologs for RELT Gene

This gene was present in the common ancestor of chordates.

Orthologs for RELT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RELT 34 35
  • 99.46 (n)
(Canis familiaris)
Mammalia RELT 34 35
  • 86.26 (n)
(Bos Taurus)
Mammalia RELT 34 35
  • 84.88 (n)
(Mus musculus)
Mammalia Relt 34 16 35
  • 84.54 (n)
(Rattus norvegicus)
Mammalia Relt 34
  • 83.37 (n)
(Monodelphis domestica)
Mammalia RELT 35
  • 63 (a)
(Gallus gallus)
Aves RELT 34 35
  • 61.81 (n)
(Anolis carolinensis)
Reptilia RELT 35
  • 53 (a)
(Danio rerio)
Actinopterygii relt 34 35
  • 55.62 (n)
Species where no ortholog for RELT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RELT Gene

Gene Tree for RELT (if available)
Gene Tree for RELT (if available)

Paralogs for RELT Gene

Paralogs for RELT Gene

genes like me logo Genes that share paralogs with RELT: view

Variants for RELT Gene

Sequence variations from dbSNP and Humsavar for RELT Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1002126 -- 73,393,151(-) AAGGG(G/T)CTCTG intron-variant, utr-variant-5-prime
rs1002127 -- 73,392,790(-) TAACT(C/G)CAAGG intron-variant, utr-variant-5-prime
rs1050743 -- 73,396,556(+) TGTTT(C/T)TCTTA nc-transcript-variant, utr-variant-3-prime
rs10793059 -- 73,382,314(+) CAAAG(C/T)CTCTG intron-variant
rs111294854 -- 73,394,718(+) TCACC(A/C/G)TCTTG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RELT Gene

Variant ID Type Subtype PubMed ID
nsv1126300 CNV deletion 24896259
nsv825993 CNV gain 20364138
nsv832208 CNV gain 17160897
nsv951041 CNV deletion 24416366

Variation tolerance for RELT Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RELT Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RELT Gene

Disorders for RELT Gene

Relevant External Links for RELT

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RELT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RELT Gene

Publications for RELT Gene

  1. RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB. (PMID: 11313261) Sica G.L. … Chen L. (Blood 2001) 2 3 4 22 64
  2. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. (PMID: 16389068) Cusick J.K. … Shu H.-B. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 64
  3. Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. (PMID: 16547002) Bossen C. … Schneider P. (J. Biol. Chem. 2006) 2 3 64
  4. TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis. (PMID: 16950202) Polek T.C. … Spivak-Kroizman T.R. (Biochem. Biophys. Res. Commun. 2006) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for RELT Gene

Sources for RELT Gene

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