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RELT Gene

protein-coding   GIFtS: 57
GCID: GC11P073087

RELT Tumor Necrosis Factor Receptor

(Previous names: tumor necrosis factor receptor superfamily, member 19-like)
(Previous symbol: TNFRSF19L)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RELT Tumor Necrosis Factor Receptor1 2
TNFRSF19L1 2 3 5
Receptor Expressed In Lymphoid Tissues2 3
Tumor Necrosis Factor Receptor Superfamily, Member 19-Like1
TRLT2
Tumor Necrosis Factor Receptor Superfamily Member 19L2

External Ids:    HGNC: 137641   Entrez Gene: 849572   Ensembl: ENSG000000549677   OMIM: 6112115   UniProtKB: Q969Z43   

Export aliases for RELT gene to outside databases

Previous GC identifers: GC11P072766 GC11P069382


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RELT Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant
in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF
receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the
presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced
transcript variants of this gene encoding the same protein have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for RELT Gene:
RELT (RELT tumor necrosis factor receptor) is a protein-coding gene. An important paralog of this gene is RELL1.

UniProtKB/Swiss-Prot: TR19L_HUMAN, Q969Z4
Function: Mediates activation of NF-kappa-B. May play a role in T-cell activation

Gene Wiki entry for RELT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RELT gene promoter:
         NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RELT promoter sequence
   Search Chromatin IP Primers for RELT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RELT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.2

RELT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RELT gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P073087:  view genomic region     (about GC identifiers)

Start:
73,087,309 bp from pter      End:
73,108,519 bp from pter
Size:
21,211 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TR19L_HUMAN, Q969Z4 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 19L precursor  
Size: 430 amino acids; 46092 Da
Subunit: Associates with TRAF1. Interacts with RELL1, RELL2 and OXSR1
Sequence caution: Sequence=BAB84954.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q86V34 Q96JU1 Q9BUX7

Explore the universe of human proteins at neXtProt for RELT: NX_Q969Z4

Explore proteomics data for RELT at MOPED

Post-translational modifications: 

  • Phosphorylated in vitro by OXSR11
  • Glycosylation2 at Asn149
  • Modification sites at PhosphoSitePlus

  • See RELT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_116260.2  NP_689408.1  

    ENSEMBL proteins: 
     ENSP00000064780   ENSP00000439352   ENSP00000440562   ENSP00000377207  

    RELT Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for RELT
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RELT
    GenScript Custom Purified and Recombinant Proteins Services for RELT
    Novus Biologicals RELT Proteins
    Novus Biologicals RELT Lysates
    Sino Biological Recombinant Protein for RELT
    Sino Biological Cell Lysate for RELT
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for RELT 

    RELT Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for RELT (RELT/TNFRSF19L)
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    Novus Biologicals RELT Antibodies
    Abcam antibodies for RELT
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for RELT
    LSBio Antibodies in human, mouse, rat for RELT

    RELT Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for RELT 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: RELT
    Tumour necrosis factor (TNF) receptor family

    3 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR022333 TNFR_19-like
     IPR022248 TNF_rcpt_RELT

    Graphical View of Domain Structure for InterPro Entry Q969Z4

    ProtoNet protein and cluster: Q969Z4

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TR19L_HUMAN, Q969Z4
    Similarity: Belongs to the RELT family
    Similarity: Contains 1 TNFR-Cys repeat


    Find genes that share domains with RELT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TR19L_HUMAN, Q969Z4
    Function: Mediates activation of NF-kappa-B. May play a role in T-cell activation

    Phenotypes:
         1 GenomeRNAi human phenotype for RELT:

     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RELT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RELT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RELT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RELT

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat RELT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RELT (see all 35):
    hsa-miR-194* hsa-miR-4272 hsa-miR-15a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-486-3p hsa-miR-449a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidRELT 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RELT
    Predesigned siRNA for gene silencing in human, mouse, rat RELT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RELT

    Clone
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    OriGene clones in human, mouse for RELT (see all 11)
    OriGene ORF clones in mouse, rat for RELT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RELT (NM_152222)
    Sino Biological Human cDNA Clone for RELT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RELT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELT

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RELT
    Browse ESI BIO Cell Lines and PureStem Progenitors for RELT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TR19L_HUMAN, Q969Z4: Cell membrane; Single-pass type I membrane protein. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with RELT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RELT About    
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43


    Find genes that share SuperPaths with RELT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RELT
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RELT
        TNF Superfamily Pathway

    3 Sino Biological Pathways for RELT
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for RELT):
        Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including RELT: 
              TNF Ligands & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RELT

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RELT (Q969Z43 ENSP000000647804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELL1Q8IUW53, ENSP000003133854I2D: score=1 STRING: ENSP00000313385
    STK39Q9UEW83, ENSP000003482784I2D: score=1 STRING: ENSP00000348278
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RELT (TR19L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RELT gene (2 alternative transcripts): 
    NM_032871.3  NM_152222.1  

    Unigene Cluster for RELT:

    RELT tumor necrosis factor receptor
    Hs.533720  [show with all ESTs]
    Unigene Representative Sequence: NM_032871
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000064780(uc001otv.3 uc001otw.3) ENST00000545687 ENST00000544075
    ENST00000393580(uc009yto.1) ENST00000545886 ENST00000539134(uc001otx.3)
    ENST00000537771
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RELT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RELT (see all 35):
    hsa-miR-194* hsa-miR-4272 hsa-miR-15a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-486-3p hsa-miR-449a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidRELT 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RELT
    Predesigned siRNA for gene silencing in human, mouse, rat RELT
    Clone
    Products:
         
    OriGene clones in human, mouse for RELT (see all 11)
    OriGene ORF clones in mouse, rat for RELT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RELT (NM_152222)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RELT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELT
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RELT
    OriGene qSTAR qPCR primer pairs in human, mouse for RELT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RELT
      QuantiTect SYBR Green Assays in human, mouse, rat RELT
      QuantiFast Probe-based Assays in human, mouse, rat RELT

    Additional mRNA sequence: 

    AK027899.1 AK310103.1 BC001812.2 BC017279.2 BC051810.1 

    6 DOTS entries:

    DT.409723  DT.100026258  DT.97858758  DT.95081124  DT.120690506  DT.91861349 

    Selected AceView cDNA sequences (see all 102):

    BX102739 AK074128 BQ679844 BM708834 AW450817 NM_152222 BC051810 BM809499 
    BQ220894 AW276243 BM695388 AI523987 BQ682129 AI364803 CD370879 NM_032871 
    AA251791 AI357545 AI949593 BM809489 H45245 CK000095 BM796984 AI223336 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RELT (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                    -     -     -     -                                         -                       -     -                                 
    SP2:                          -     -     -                                         -                       -     -                                 
    SP3:                                                                                -                                                               
    SP4:                    -                 -                                                                                                         
    SP5:                    -     -     -     -                 -     -                 -                                                               


    ECgene alternative splicing isoforms for RELT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RELT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTGAATAA
    RELT Expression
    About this image

    RELT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RELT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533720

    UniProtKB/Swiss-Prot: TR19L_HUMAN, Q969Z4
    Tissue specificity: Highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and
    fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including RELT: 
              TNF Ligands & Receptors in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RELT
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    QuantiFast Probe-based Assays in human, mouse, rat RELT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RELT gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Relt1 , 5 RELT tumor necrosis factor receptor1, 5 84.54(n)1
    86.01(a)1
      7 (54.44 cM)5
    3201001  NM_177073.61  NP_796047.21 
     1008458485 
    chicken
    (Gallus gallus)
    Aves RELT1 RELT tumor necrosis factor receptor 61.81(n)
    57.59(a)
      419067  XM_003640623.2  XP_003640671.1 
    lizard
    (Anolis carolinensis)
    Reptilia RELT6
    RELT tumor necrosis factor receptor
    53(a)
    1 ↔ 1
    GL343337.1(1264908-1273999)
    zebrafish
    (Danio rerio)
    Actinopterygii relt1 RELT tumor necrosis factor receptor 55.62(n)
    50(a)
      404605  NM_207073.1  NP_996956.1 


    ENSEMBL Gene Tree for RELT (if available)
    TreeFam Gene Tree for RELT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RELT gene
    RELL12  RELL22  

    Find genes that share paralogs with RELT           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RELT (see all 490)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446303381,2
    C--73085465(+) TTTCAC/GGGTCA 1 -- us2k10--------
    rs590006541,2
    F--73085565(+) TGTTTG/CGGCTG 1 -- us2k12Minor allele frequency- C:0.07CSA WA 120
    rs1871100811,2
    --73085795(+) CCCCAC/TTTAGT 2 -- us2k10--------
    rs600789071,2
    C,F--73085834(+) TCACCT/CAGGCT 2 -- us2k18Minor allele frequency- C:0.30WA NA CSA 248
    rs1159879631,2
    F--73085901(+) ATTCTC/TCCACA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1478647911,2
    --73086067(+) TGAAAC/TTGCCA 2 -- us2k10--------
    rs1922760931,2
    --73086212(+) CCAGCC/TCTGGA 2 -- us2k10--------
    rs8764801,2
    C,F,A,H--73086303(-) CATGCT/CCAGGT 2 -- us2k126Minor allele frequency- C:0.31NS EA NA WA CSA 2703
    rs1845173561,2
    --73086310(+) CATGAA/CCCAGG 2 -- us2k10--------
    rs1896174941,2
    C--73086351(+) CCATGC/TGGTGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RELT (73087309 - 73108519 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RELT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897911CNV Loss21882294
    nsv825993CNV Gain20364138
    nsv832208CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RELT
    DNA2.0 Custom Variant and Variant Library Synthesis for RELT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611211    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for RELT:
    Liver disease

    Find genes that share disorders with RELT           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: RELT (1 document)

    Export disorders for RELT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RELT gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with RELT)
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    1. RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB. (PubMed id 11313261)1, 2, 3, 9 Sica G.L.... Chen L. (Blood 2001)
    2. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. (PubMed id 16389068)1, 2, 3 Cusick J.K.... Shu H.-B. (Biochem. Biophys. Res. Commun. 2006)
    3. Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. (PubMed id 16547002)1, 3 Bossen C....Schneider P. (J. Biol. Chem. 2006)
    4. TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis. (PubMed id 16950202)1, 3 Polek T.C....Spivak-Kroizman T.R. (Biochem. Biophys. Res. Commun. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. RELT induces cellular death in HEK 293 epithelial cells. (PubMed id 19969290)1 Cusick J.K....Reyland M.E. (Cell. Immunol. 2010)
    9. The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation. (PubMed id 16530727)1 Polek T.C....Spivak-Kroizman T. (Biochem. Biophys. Res. Commun. 2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84957 HGNC: 13764 AceView: TNFRSF19L Ensembl:ENSG00000054967 euGenes: HUgn84957
    ECgene: RELT Kegg: 84957 H-InvDB: RELT

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RELT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RELT gene:
    Search GeneIP for patents involving RELT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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