RELL2 Gene
protein-coding GIFtS: 44
GCID: GC05P141266
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RELT-like 2(Previous name: chromosome 5 open reading frame 16 )
(Previous symbol: C5orf16)
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Aliases
for RELL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RELT-Like 21 2 | | C5orf161 2 3 | | FLJ905831 | | Chromosome 5 Open Reading Frame 161 | | Receptor Expressed In Lymphoid Tissues Like 22 | | RELT-Like Protein 22 |
Export aliases for RELL2 gene to outside databasesPrevious GC identifers: GC05P140997 GC05P141003 GC05P141028 GC05P141059 GC05P141086 GC05P136161 GC05P141127 GC05P141160 GC05P141192 GC05P141225 |
Summaries
for RELL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RELL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RELL2 gene promoter:
AP-2alpha isoform 3 AP-1 AP-2alpha isoform 4 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for RELL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RELL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.3 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31.3RELL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P141266: view genomic region
(about GC identifiers)
Start:
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141,016,517 bp from pter |
End:
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141,020,644 bp from pter |
Size:
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4,128 bases |
Orientation:
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plus strand |
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Proteins
for RELL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RELL2_HUMAN, Q8NC24 (See
protein sequence)Recommended Name: RELT-like protein 2 Size: 303 amino acids; 32405 Da
Subunit: Interacts with RELT, RELL1 and OXSR1
Subcellular location: Cell membrane; Single-pass membrane protein
Secondary accessions: D3DQE2 Q6P4E7 Q6UXY2Explore the universe of human proteins at neXtProt for RELL2: NX_Q8NC24
Post-translational modifications:
Phosphorylated in vitro by OXSR11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NC24
RELL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001123501.1 NP_776189.3
ENSEMBL proteins: ENSP00000430948 ENSP00000297164 ENSP00000427992 ENSP00000409443
Human Recombinant Protein Products for RELL2:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RELL2 for ontologies About GeneDecksing
RELL2 Antibody Products:
Assay Products for RELL2: |
Protein
Domains /
Families
for RELL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RELL2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NC24ProtoNet protein and cluster: Q8NC24 UniProtKB/Swiss-Prot: RELL2_HUMAN, Q8NC24Similarity: Belongs to the RELT family |
Function
for RELL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005518 | collagen binding |
IEA | -- |
RELL2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RELL2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RELL2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RELL2 (NM_001130029) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RELL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELL2 |
|
Pathways & Interactions
for RELL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RELL2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for RELL2 (Q8NC243 ENSP000002971644) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010811 | positive regulation of cell-substrate adhesion |
IEA | -- |
RELL2 for ontologies About GeneDecksing
|
Drugs & Compounds
for RELL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RELL2
Search CenterWatch for drugs/clinical trials and news about RELL2
|
Transcripts
for RELL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RELL2 gene (2 alternative transcripts): NM_001130029.1 NM_173828.4 Unigene Cluster for RELL2: RELT-like 2 Hs.120094 [show with all ESTs]Unigene Representative Sequence: BC0279197 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000520674 ENST00000518025 ENST00000521367 ENST00000297164(uc003llh.3)
ENST00000517794 ENST00000518856 ENST00000444782(uc003lli.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RELL2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RELL2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RELL2 (NM_001130029) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RELL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELL2 |
Additional cDNA sequence: AK054889.1 AK075064.1 AY358163.1 BC009560.1 BC027919.1 BC063469.1 12 DOTS entries: DT.75173568 DT.100796558 DT.92426748 DT.120855898 DT.100796561 DT.409936 DT.100796559 DT.100796562 DT.100796563 DT.120855919 DT.95076258 DT.95212621 24/94 AceView cDNA sequences (see all 94): BM561747 BU579829 AI269328 CB988029 CD101718 BU689015 BX280066 BQ130519 AI651596 BU685044 BC009560 CR600554 CB990073 BX350633 CK905857 CK299867 BF509477 CA405760 CR615264 BX400343 AL120315 BF509785 BI757135 BC027919
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for RELL2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 |
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| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for RELL2
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Expression
for RELL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RELL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAGGCTGC
About this image
See RELL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RELL2
SOURCE GeneReport for Unigene cluster: Hs.120094
UniProtKB/Swiss-Prot: RELL2_HUMAN, Q8NC24Tissue specificity: Primarily expressed in spleen, thymus, testis, peripheral blood leukocytes, brain and placenta. Notdetected in prostate, ovary, small intestine, colon, heart, lung, liver, skeletal muscle, kidney and pancreas
SABiosciences Custom PCR Arrays for RELL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RELL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RELL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RELL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RELL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELL2 |
Orthologs
for RELL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RELL2 gene from 5/11 species (see all 11) About this table
ENSEMBL Gene Tree for RELL2 (if available)
TreeFam Gene Tree for RELL2 (if available) |
Paralogs
for RELL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RELL2 gene
- RELL12 RELT2
1 SIMAP similar gene for RELL2 using alignment to 3 protein entries: RELL2_HUMAN (see all proteins):RELL1
RELL2 for paralogs About GeneDecksing
|
Genomic Variants
for RELL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RELL2 |
|
Disorders
/ Diseases
for RELL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RELL2 for disorders About GeneDecksing
OMIM gene information: 611213
OMIM disorders: --
1  disease for RELL2: About MalaCardsprostatitis
Export disorders for RELL2 gene to outside databases
|
Publications
for RELL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RELL2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RELL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. (PubMed id 16389068)1, 2, 3 Cusick J.K.... Shu H.-B. (2006)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (2012)
- RELT induces cellular death in HEK 293 epithelial cel ls. (PubMed id 19969290)1 Cusick J.K....Reyland M.E. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for RELL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RELL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RELL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RELL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RELL2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RELL2 gene:
Search GeneIP for patents involving RELL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RELL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RELL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RELL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RELL2 | | | OriGene Protein Over-expression Lysate for RELL2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RELL2 | | OriGene 3'-UTR Clone for RELL2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RELL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RELL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RELL2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RELL2 | | OriGene Custom Protein Services for RELL2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RELL2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RELL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RELL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RELL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RELL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RELL2 |
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| | | | Search Tocris compounds for RELL2 |
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 | | | RELL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELL2 |
|  |  |  |  | | | | ThermoFisher Antibodies for RELL2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELL2 |
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