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Aliases for RELL2 Gene

Aliases for RELL2 Gene

  • RELT Like 2 2 3 5
  • C5orf16 3 4
  • Receptor Expressed In Lymphoid Tissues Like 2 3
  • Chromosome 5 Open Reading Frame 16 2
  • RELT-Like Protein 2 3
  • RELT-Like 2 2

External Ids for RELL2 Gene

Previous HGNC Symbols for RELL2 Gene

  • C5orf16

Previous GeneCards Identifiers for RELL2 Gene

  • GC05P140997
  • GC05P141003
  • GC05P141028
  • GC05P141059
  • GC05P141086
  • GC05P136161
  • GC05P141127
  • GC05P141160
  • GC05P141192
  • GC05P141225
  • GC05P141266
  • GC05P141343
  • GC05P141399

Summaries for RELL2 Gene

GeneCards Summary for RELL2 Gene

RELL2 (RELT Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include collagen binding. An important paralog of this gene is RELT.

Additional gene information for RELL2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RELL2 Gene

Genomics for RELL2 Gene

GeneHancer (GH) Regulatory Elements for RELL2 Gene

Promoters and enhancers for RELL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I141633 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 561.2 -0.4 -430 5.2 HDGF ARID4B SIN3A FEZF1 IRF4 ZNF213 ZNF143 SP3 SP5 JUNB RELL2 HDAC3 PCDHB19P PCDHGA6 PCDHGB8P PCDHGB6 GC05M141465
GH05I141601 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.1 -31.0 -30960 8.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A IRF4 YY1 ZNF766 CBX5 RELL2 HDAC3 FCHSD1 DIAPH1 LOC100505658 PCDHGA6 PCDHGB6 KIAA0141 PCDHGA1 PCDH12
GH05I141597 Enhancer 1 Ensembl ENCODE dbSUPER 21.9 -37.5 -37508 4.1 MEIS2 PKNOX1 BATF IKZF1 ETV6 IKZF2 PRDM4 SETDB1 SPI1 RELL2 HDAC3 FCHSD1 LOC100505658 PCDHGA8 GC05P142212 RPS27AP10 DIAPH1 LOC102723915 GC05M141465
GH05I141615 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.2 -19.0 -19012 4 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 DIAPH1 LOC102723915 RELL2 ARAP3 GC05M141465 GC05P142212 RPS27AP10
GH05I141691 Enhancer 1.2 Ensembl ENCODE 10.8 +55.1 55072 1.6 ARNT ARID4B SIN3A ZNF2 IRF4 ZNF766 ZNF213 ZNF207 ZNF143 KLF13 RNF14 PCDH12 PCDH1 FCHSD1 RELL2 HDAC3 KIAA0141 GNPDA1 ARAP3 ENSG00000278925
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RELL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RELL2 gene promoter:

Genomic Locations for RELL2 Gene

Genomic Locations for RELL2 Gene
4,132 bases
Plus strand

Genomic View for RELL2 Gene

Genes around RELL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RELL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RELL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RELL2 Gene

Proteins for RELL2 Gene

  • Protein details for RELL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RELT-like protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DQE2
    • Q6P4E7
    • Q6UXY2

    Protein attributes for RELL2 Gene

    303 amino acids
    Molecular mass:
    32405 Da
    Quaternary structure:
    • Interacts with RELT, RELL1 and OXSR1.

neXtProt entry for RELL2 Gene

Post-translational modifications for RELL2 Gene

Other Protein References for RELL2 Gene

No data available for DME Specific Peptides for RELL2 Gene

Domains & Families for RELL2 Gene

Gene Families for RELL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RELL2 Gene


Suggested Antigen Peptide Sequences for RELL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RELT family.
  • Belongs to the RELT family.
genes like me logo Genes that share domains with RELL2: view

Function for RELL2 Gene

Phenotypes From GWAS Catalog for RELL2 Gene

Gene Ontology (GO) - Molecular Function for RELL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005518 collagen binding IEA --
genes like me logo Genes that share ontologies with RELL2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RELL2 Gene

Localization for RELL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RELL2 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RELL2 gene
Compartment Confidence
plasma membrane 4
extracellular 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RELL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005604 basement membrane IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RELL2: view

Pathways & Interactions for RELL2 Gene

SuperPathways for RELL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RELL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010811 positive regulation of cell-substrate adhesion IEA --
genes like me logo Genes that share ontologies with RELL2: view

No data available for Pathways by source and SIGNOR curated interactions for RELL2 Gene

Drugs & Compounds for RELL2 Gene

No Compound Related Data Available

Transcripts for RELL2 Gene

Unigene Clusters for RELL2 Gene

RELT-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RELL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
SP2: -

Relevant External Links for RELL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RELL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RELL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RELL2 Gene

This gene is overexpressed in Brain - Cortex (x4.7) and Pituitary (x4.3).

Protein differential expression in normal tissues from HIPED for RELL2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RELL2 Gene

Protein tissue co-expression partners for RELL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RELL2 Gene:


SOURCE GeneReport for Unigene cluster for RELL2 Gene:


mRNA Expression by UniProt/SwissProt for RELL2 Gene:

Tissue specificity: Primarily expressed in spleen, thymus, testis, peripheral blood leukocytes, brain and placenta. Not detected in prostate, ovary, small intestine, colon, heart, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for RELL2 Gene

  • Blood(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with RELL2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RELL2 Gene

Orthologs for RELL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RELL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RELL2 33 34
  • 99.45 (n)
(Canis familiaris)
Mammalia RELL2 33 34
  • 90.87 (n)
(Bos Taurus)
Mammalia RELL2 33 34
  • 90.21 (n)
(Mus musculus)
Mammalia Rell2 33 16 34
  • 86.91 (n)
(Rattus norvegicus)
Mammalia Rell2 33
  • 84.22 (n)
(Monodelphis domestica)
Mammalia RELL2 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia RELL2 34
  • 55 (a)
(Gallus gallus)
Aves RELL2 34
  • 35 (a)
(Anolis carolinensis)
Reptilia RELL2 34
  • 51 (a)
(Danio rerio)
Actinopterygii RELL2 34
  • 23 (a)
Species where no ortholog for RELL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RELL2 Gene

Gene Tree for RELL2 (if available)
Gene Tree for RELL2 (if available)

Paralogs for RELL2 Gene

Paralogs for RELL2 Gene

(1) SIMAP similar genes for RELL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RELL2: view

Variants for RELL2 Gene

Sequence variations from dbSNP and Humsavar for RELL2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000405355 -- 141,635,654(+) CAACTCAGGC/C upstream_transcript_variant
rs1000738666 -- 141,635,114(+) G/T upstream_transcript_variant
rs1001189800 -- 141,635,758(+) C/T upstream_transcript_variant
rs1001569293 -- 141,636,124(+) C/T upstream_transcript_variant
rs1001725897 -- 141,640,771(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for RELL2 Gene

Variant ID Type Subtype PubMed ID
nsv1154058 CNV deletion 26484159

Variation tolerance for RELL2 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.08; 93.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RELL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RELL2 Gene

Disorders for RELL2 Gene

Additional Disease Information for RELL2

No disorders were found for RELL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RELL2 Gene

Publications for RELL2 Gene

  1. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. (PMID: 16389068) Cusick JK … Shu HB (Biochemical and biophysical research communications 2006) 2 3 4 58
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RELL2 Gene

Sources for RELL2 Gene

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