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Aliases for RELL2 Gene

Aliases for RELL2 Gene

  • RELT Like 2 2 3
  • RELT-Like 2 2 3 5
  • C5orf16 3 4
  • Receptor Expressed In Lymphoid Tissues Like 2 3
  • Chromosome 5 Open Reading Frame 16 2

External Ids for RELL2 Gene

Previous HGNC Symbols for RELL2 Gene

  • C5orf16

Previous GeneCards Identifiers for RELL2 Gene

  • GC05P140997
  • GC05P141003
  • GC05P141028
  • GC05P141059
  • GC05P141086
  • GC05P136161
  • GC05P141127
  • GC05P141160
  • GC05P141192
  • GC05P141225
  • GC05P141266
  • GC05P141343
  • GC05P141399

Summaries for RELL2 Gene

GeneCards Summary for RELL2 Gene

RELL2 (RELT Like 2) is a Protein Coding gene. GO annotations related to this gene include collagen binding. An important paralog of this gene is RELL1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RELL2 Gene

Genomics for RELL2 Gene

Regulatory Elements for RELL2 Gene

Enhancers for RELL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RELL2 on UCSC Golden Path with GeneCards custom track

Promoters for RELL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RELL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RELL2 Gene

141,636,946 bp from pter
141,641,077 bp from pter
4,132 bases
Plus strand

Genomic View for RELL2 Gene

Genes around RELL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RELL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RELL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RELL2 Gene

Proteins for RELL2 Gene

  • Protein details for RELL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RELT-like protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DQE2
    • Q6P4E7
    • Q6UXY2

    Protein attributes for RELL2 Gene

    303 amino acids
    Molecular mass:
    32405 Da
    Quaternary structure:
    • Interacts with RELT, RELL1 and OXSR1.

neXtProt entry for RELL2 Gene

Proteomics data for RELL2 Gene at MOPED

Post-translational modifications for RELL2 Gene

Other Protein References for RELL2 Gene

No data available for DME Specific Peptides for RELL2 Gene

Domains & Families for RELL2 Gene

Protein Domains for RELL2 Gene


Suggested Antigen Peptide Sequences for RELL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RELT family.
  • Belongs to the RELT family.
genes like me logo Genes that share domains with RELL2: view

No data available for Gene Families for RELL2 Gene

Function for RELL2 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RELL2 Gene

Localization for RELL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RELL2 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RELL2 Gene COMPARTMENTS Subcellular localization image for RELL2 gene
Compartment Confidence
extracellular 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for RELL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RELL2: view

Pathways & Interactions for RELL2 Gene

SuperPathways for RELL2 Gene

No Data Available

Interacting Proteins for RELL2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000297164 Q8NC24-RELL2_HUMAN for RELL2 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for RELL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for RELL2 Gene

Drugs & Compounds for RELL2 Gene

No Compound Related Data Available

Transcripts for RELL2 Gene

Unigene Clusters for RELL2 Gene

RELT-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RELL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
SP2: -

Relevant External Links for RELL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RELL2 Gene

mRNA expression in normal human tissues for RELL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RELL2 Gene

This gene is overexpressed in Brain - Cortex (x4.7) and Pituitary (x4.3).

Protein differential expression in normal tissues from HIPED for RELL2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RELL2 Gene

SOURCE GeneReport for Unigene cluster for RELL2 Gene Hs.120094

mRNA Expression by UniProt/SwissProt for RELL2 Gene

Tissue specificity: Primarily expressed in spleen, thymus, testis, peripheral blood leukocytes, brain and placenta. Not detected in prostate, ovary, small intestine, colon, heart, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with RELL2: view

Protein tissue co-expression partners for RELL2 Gene

Primer Products

Orthologs for RELL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RELL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RELL2 35
  • 90.21 (n)
  • 91.09 (a)
RELL2 36
  • 91 (a)
(Canis familiaris)
Mammalia RELL2 35
  • 90.87 (n)
  • 90.1 (a)
RELL2 36
  • 90 (a)
(Mus musculus)
Mammalia Rell2 35
  • 86.91 (n)
  • 84.82 (a)
Rell2 16
Rell2 36
  • 85 (a)
(Pan troglodytes)
Mammalia RELL2 35
  • 99.45 (n)
  • 99.01 (a)
RELL2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rell2 35
  • 84.22 (n)
  • 82.12 (a)
(Monodelphis domestica)
Mammalia RELL2 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia RELL2 36
  • 55 (a)
(Gallus gallus)
Aves RELL2 36
  • 35 (a)
(Anolis carolinensis)
Reptilia RELL2 36
  • 51 (a)
(Danio rerio)
Actinopterygii RELL2 36
  • 23 (a)
Species with no ortholog for RELL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RELL2 Gene

Gene Tree for RELL2 (if available)
Gene Tree for RELL2 (if available)

Paralogs for RELL2 Gene

Paralogs for RELL2 Gene

(1) SIMAP similar genes for RELL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RELL2: view

Variants for RELL2 Gene

Sequence variations from dbSNP and Humsavar for RELL2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_027496 -
VAR_027497 -
VAR_027498 -
VAR_027499 -

Variation tolerance for RELL2 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.08; 93.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RELL2 Gene

Disorders for RELL2 Gene

Relevant External Links for RELL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RELL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RELL2 Gene

Publications for RELL2 Gene

  1. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. (PMID: 16389068) Cusick J.K. … Shu H.-B. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PMID: 22379092) Shamay M. … Hayward S.D. (J. Virol. 2012) 3
  5. RELT induces cellular death in HEK 293 epithelial cells. (PMID: 19969290) Cusick J.K. … Reyland M.E. (Cell. Immunol. 2010) 3

Products for RELL2 Gene

Sources for RELL2 Gene