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Aliases for RELL2 Gene

Aliases for RELL2 Gene

  • RELT-Like 2 2 3
  • C5orf16 3 4
  • Receptor Expressed In Lymphoid Tissues Like 2 3
  • Chromosome 5 Open Reading Frame 16 2
  • RELT-Like Protein 2 3

External Ids for RELL2 Gene

Previous HGNC Symbols for RELL2 Gene

  • C5orf16

Previous GeneCards Identifiers for RELL2 Gene

  • GC05P140997
  • GC05P141003
  • GC05P141028
  • GC05P141059
  • GC05P141086
  • GC05P136161
  • GC05P141127
  • GC05P141160
  • GC05P141192
  • GC05P141225
  • GC05P141266
  • GC05P141343
  • GC05P141399

Summaries for RELL2 Gene

GeneCards Summary for RELL2 Gene

RELL2 (RELT-Like 2) is a Protein Coding gene. GO annotations related to this gene include collagen binding. An important paralog of this gene is RELL1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RELL2 Gene

Genomics for RELL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RELL2 Gene

141,636,950 bp from pter
141,641,077 bp from pter
4,128 bases
Plus strand

Genomic View for RELL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RELL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RELL2 Gene

Proteins for RELL2 Gene

  • Protein details for RELL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RELT-like protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DQE2
    • Q6P4E7
    • Q6UXY2

    Protein attributes for RELL2 Gene

    303 amino acids
    Molecular mass:
    32405 Da
    Quaternary structure:
    • Interacts with RELT, RELL1 and OXSR1.

neXtProt entry for RELL2 Gene

Proteomics data for RELL2 Gene at MOPED

Post-translational modifications for RELL2 Gene

Other Protein References for RELL2 Gene

No data available for DME Specific Peptides for RELL2 Gene

Domains for RELL2 Gene

Protein Domains for RELL2 Gene


Suggested Antigen Peptide Sequences for RELL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8NC24
  • Belongs to the RELT family.
genes like me logo Genes that share domains with RELL2: view

No data available for Gene Families for RELL2 Gene

Function for RELL2 Gene

Gene Ontology (GO) - Molecular Function for RELL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005518 collagen binding IEA --
genes like me logo Genes that share ontologies with RELL2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RELL2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RELL2 Gene

Localization for RELL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RELL2 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RELL2 Gene COMPARTMENTS Subcellular localization image for RELL2 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for RELL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with RELL2: view

Pathways for RELL2 Gene

SuperPathways for RELL2 Gene

No Data Available

Interacting Proteins for RELL2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000297164 Q8NC24-RELL2_HUMAN for RELL2 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for RELL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010811 positive regulation of cell-substrate adhesion IEA --
genes like me logo Genes that share ontologies with RELL2: view

No data available for Pathways by source for RELL2 Gene

Transcripts for RELL2 Gene

Unigene Clusters for RELL2 Gene

RELT-like 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RELL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RELL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
SP2: -

Relevant External Links for RELL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RELL2 Gene

mRNA expression in normal human tissues for RELL2 Gene

mRNA differential expression in normal tissues according to GTEx for RELL2 Gene

This gene is overexpressed in Brain - Cortex (4.7) and Pituitary (4.3).

Protein differential expression in normal tissues for RELL2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RELL2 Gene

SOURCE GeneReport for Unigene cluster for RELL2 Gene Hs.120094

mRNA Expression by UniProt/SwissProt for RELL2 Gene

Tissue specificity: Primarily expressed in spleen, thymus, testis, peripheral blood leukocytes, brain and placenta. Not detected in prostate, ovary, small intestine, colon, heart, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with RELL2: view

Expression partners for RELL2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RELL2 Gene

Orthologs for RELL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RELL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RELL2 35
  • 90.21 (n)
  • 91.09 (a)
RELL2 36
  • 91 (a)
(Canis familiaris)
Mammalia RELL2 35
  • 90.87 (n)
  • 90.1 (a)
RELL2 36
  • 90 (a)
(Mus musculus)
Mammalia Rell2 35
  • 86.91 (n)
  • 84.82 (a)
Rell2 16
Rell2 36
  • 85 (a)
(Pan troglodytes)
Mammalia RELL2 35
  • 99.45 (n)
  • 99.01 (a)
RELL2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rell2 35
  • 84.22 (n)
  • 82.12 (a)
(Monodelphis domestica)
Mammalia RELL2 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia RELL2 36
  • 55 (a)
(Gallus gallus)
Aves RELL2 36
  • 35 (a)
(Anolis carolinensis)
Reptilia RELL2 36
  • 51 (a)
(Danio rerio)
Actinopterygii RELL2 36
  • 23 (a)
Species with no ortholog for RELL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RELL2 Gene

Gene Tree for RELL2 (if available)
Gene Tree for RELL2 (if available)

Paralogs for RELL2 Gene

Paralogs for RELL2 Gene

Selected SIMAP similar genes for RELL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RELL2: view

Variants for RELL2 Gene

Sequence variations from dbSNP and Humsavar for RELL2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_027496 -
VAR_027497 -
VAR_027498 -
VAR_027499 -

Relevant External Links for RELL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RELL2 Gene

Disorders for RELL2 Gene

No disorders were found for RELL2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RELL2 Gene

Publications for RELL2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. (PMID: 16389068) Cusick J.K. … Shu H.-B. (Biochem. Biophys. Res. Commun. 2006) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for RELL2 Gene

Sources for RELL2 Gene

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