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Aliases for RELL1 Gene

Aliases for RELL1 Gene

  • RELT Like 1 2 3
  • RELT-Like 1 2 3 5
  • Receptor Expressed In Lymphoid Tissues Like 1 3
  • Tmp_locus_29 3

External Ids for RELL1 Gene

Previous GeneCards Identifiers for RELL1 Gene

  • GC00U922272
  • GC04U900697
  • GC04M037269
  • GC04M036916

Summaries for RELL1 Gene

GeneCards Summary for RELL1 Gene

RELL1 (RELT Like 1) is a Protein Coding gene. An important paralog of this gene is RELT.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RELL1 Gene

Genomics for RELL1 Gene

Regulatory Elements for RELL1 Gene

Promoters for RELL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RELL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RELL1 Gene

Chromosome:
4
Start:
37,588,059 bp from pter
End:
37,686,377 bp from pter
Size:
98,319 bases
Orientation:
Minus strand

Genomic View for RELL1 Gene

Genes around RELL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RELL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RELL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RELL1 Gene

Proteins for RELL1 Gene

  • Protein details for RELL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUW5-RELL1_HUMAN
    Recommended name:
    RELT-like protein 1
    Protein Accession:
    Q8IUW5
    Secondary Accessions:
    • Q8NBK1

    Protein attributes for RELL1 Gene

    Size:
    271 amino acids
    Molecular mass:
    29340 Da
    Quaternary structure:
    • Interacts with RELT, RELL2 and OXSR1.

neXtProt entry for RELL1 Gene

Proteomics data for RELL1 Gene at MOPED

Post-translational modifications for RELL1 Gene

Other Protein References for RELL1 Gene

No data available for DME Specific Peptides for RELL1 Gene

Domains & Families for RELL1 Gene

Protein Domains for RELL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RELL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUW5

UniProtKB/Swiss-Prot:

RELL1_HUMAN :
  • Belongs to the RELT family.
Family:
  • Belongs to the RELT family.
genes like me logo Genes that share domains with RELL1: view

No data available for Gene Families for RELL1 Gene

Function for RELL1 Gene

Phenotypes for RELL1 Gene

GenomeRNAi human phenotypes for RELL1:
genes like me logo Genes that share phenotypes with RELL1: view

Animal Model Products

miRNA for RELL1 Gene

miRTarBase miRNAs that target RELL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RELL1 Gene

Localization for RELL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RELL1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RELL1 Gene COMPARTMENTS Subcellular localization image for RELL1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RELL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RELL1: view

Pathways & Interactions for RELL1 Gene

SuperPathways for RELL1 Gene

No Data Available

Interacting Proteins for RELL1 Gene

Gene Ontology (GO) - Biological Process for RELL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RELL1 Gene

Drugs & Compounds for RELL1 Gene

No Compound Related Data Available

Transcripts for RELL1 Gene

mRNA/cDNA for RELL1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RELL1 Gene

RELT-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RELL1 Gene

No ASD Table

Relevant External Links for RELL1 Gene

GeneLoc Exon Structure for
RELL1
ECgene alternative splicing isoforms for
RELL1

Expression for RELL1 Gene

mRNA expression in normal human tissues for RELL1 Gene

Protein differential expression in normal tissues from HIPED for RELL1 Gene

This gene is overexpressed in Adrenal (24.6), Gallbladder (8.7), and Spinal cord (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RELL1 Gene



SOURCE GeneReport for Unigene cluster for RELL1 Gene Hs.283378

mRNA Expression by UniProt/SwissProt for RELL1 Gene

Q8IUW5-RELL1_HUMAN
Tissue specificity: Widely expressed. Expressed at highest levels in the placenta, skeletal muscle, spleen and testis.
genes like me logo Genes that share expression patterns with RELL1: view

Protein tissue co-expression partners for RELL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RELL1 Gene

Orthologs for RELL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RELL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RELL1 35
  • 99.31 (n)
  • 100 (a)
RELL1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RELL1 36
  • 86 (a)
OneToOne
RELL1 35
  • 84.75 (n)
  • 85.98 (a)
dog
(Canis familiaris)
Mammalia RELL1 35
  • 85.98 (n)
  • 88.93 (a)
RELL1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rell1 16
Rell1 36
  • 88 (a)
OneToOne
Rell1 35
  • 82.41 (n)
  • 88.19 (a)
oppossum
(Monodelphis domestica)
Mammalia RELL1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RELL1 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rell1 35
  • 82.41 (n)
  • 88.93 (a)
chicken
(Gallus gallus)
Aves RELL1 35
  • 67.95 (n)
  • 65.64 (a)
RELL1 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RELL1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rell1 35
  • 61.25 (n)
  • 61.38 (a)
zebrafish
(Danio rerio)
Actinopterygii RELL1 36
  • 42 (a)
OneToOne
LOC799556 35
  • 59.51 (n)
  • 56.59 (a)
Species with no ortholog for RELL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RELL1 Gene

ENSEMBL:
Gene Tree for RELL1 (if available)
TreeFam:
Gene Tree for RELL1 (if available)

Paralogs for RELL1 Gene

Paralogs for RELL1 Gene

(1) SIMAP similar genes for RELL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RELL1: view

Variants for RELL1 Gene

Sequence variations from dbSNP and Humsavar for RELL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs919006 -- 37,674,319(+) CTGTA(A/C)AGAAT intron-variant
rs919007 -- 37,674,540(+) AGGCC(A/G)TACGA intron-variant
rs919008 -- 37,674,556(+) TAGAA(A/C)AAACT intron-variant
rs1114272 -- 37,672,755(-) GATGT(A/G)ATGAA intron-variant
rs1396802 -- 37,671,933(+) TATTA(C/T)GAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RELL1 Gene

Variant ID Type Subtype PubMed ID
nsv829909 CNV Loss 17160897
nsv878934 CNV Gain 21882294
nsv4303 CNV Insertion 18451855
esv2727432 CNV Deletion 23290073
esv2727433 CNV Deletion 23290073
esv2727434 CNV Deletion 23290073
esv2727435 CNV Deletion 23290073
nsv822535 CNV Loss 20364138
esv2727436 CNV Deletion 23290073
esv2727437 CNV Deletion 23290073

Variation tolerance for RELL1 Gene

Residual Variation Intolerance Score: 64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RELL1 Gene

HapMap Linkage Disequilibrium report
RELL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RELL1 Gene

Disorders for RELL1 Gene

Relevant External Links for RELL1

Genetic Association Database (GAD)
RELL1
Human Genome Epidemiology (HuGE) Navigator
RELL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RELL1

No disorders were found for RELL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RELL1 Gene

Publications for RELL1 Gene

  1. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. (PMID: 16389068) Cusick J.K. … Shu H.-B. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 67
  2. Identification of PLSCR1 as a protein that interacts with RELT family members. (PMID: 22052202) Cusick J.K. … Reyland M.E. (Mol. Cell. Biochem. 2012) 2 3
  3. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. RELT induces cellular death in HEK 293 epithelial cells. (PMID: 19969290) Cusick J.K. … Reyland M.E. (Cell. Immunol. 2010) 3

Products for RELL1 Gene

Sources for RELL1 Gene

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