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Aliases for RELL1 Gene

Aliases for RELL1 Gene

  • RELT Like 1 2 3 5
  • Receptor Expressed In Lymphoid Tissues Like 1 3
  • RELT-Like Protein 1 3
  • Tmp_locus_29 3
  • RELT-Like 1 2

External Ids for RELL1 Gene

Previous GeneCards Identifiers for RELL1 Gene

  • GC00U922272
  • GC04U900697
  • GC04M037269
  • GC04M036916

Summaries for RELL1 Gene

GeneCards Summary for RELL1 Gene

RELL1 (RELT Like 1) is a Protein Coding gene. An important paralog of this gene is RELT.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RELL1 Gene

Genomics for RELL1 Gene

Regulatory Elements for RELL1 Gene

Enhancers for RELL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G037661 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +21.8 21760 7.0 FOXA2 ATF1 MLX SIN3A ARID4B FEZF1 ZNF48 YY1 GATA2 FOS RELL1 ENSG00000248936
GH04G037756 1.3 FANTOM5 Ensembl ENCODE 14.1 -71.8 -71824 2.8 MAX CEBPG RAD21 YY1 ZNF239 GATAD2A NFIA TEAD1 FOXA3 CEBPB RELL1 TBC1D1 LOC105374406 LOC105374404
GH04G037728 1.4 Ensembl ENCODE dbSUPER 11.3 -43.2 -43228 2.3 ELF3 TBP FOXA2 ARID4B RAD21 THRB ZSCAN9 RARA CREM MIXL1 RELL1 C4orf19 LOC105374404 LOC105374406
GH04G037753 1 FANTOM5 Ensembl ENCODE 15.6 -68.2 -68224 2.0 BHLHE40 ELF4 RELL1 TBC1D1 PGM2 LOC105374406 LOC105374404
GH04G037732 1.2 ENCODE dbSUPER 11.4 -46.9 -46852 1.9 ELF3 FOXA2 ATF1 MLX ZFP64 ARID4B THRB ZSCAN9 RARA YY1 RELL1 ENSG00000248936 PGM2 LOC105374404 LOC105374406
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RELL1 on UCSC Golden Path with GeneCards custom track

Promoters for RELL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000167365 177 2001 HDGF PKNOX1 ARNT MLX SIN3A ARID4B FEZF1 YY1 ZNF143 SP3

Genomic Location for RELL1 Gene

Chromosome:
4
Start:
37,588,059 bp from pter
End:
37,686,377 bp from pter
Size:
98,319 bases
Orientation:
Minus strand

Genomic View for RELL1 Gene

Genes around RELL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RELL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RELL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RELL1 Gene

Proteins for RELL1 Gene

  • Protein details for RELL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUW5-RELL1_HUMAN
    Recommended name:
    RELT-like protein 1
    Protein Accession:
    Q8IUW5
    Secondary Accessions:
    • Q8NBK1

    Protein attributes for RELL1 Gene

    Size:
    271 amino acids
    Molecular mass:
    29340 Da
    Quaternary structure:
    • Interacts with RELT, RELL2 and OXSR1.

neXtProt entry for RELL1 Gene

Post-translational modifications for RELL1 Gene

Other Protein References for RELL1 Gene

No data available for DME Specific Peptides for RELL1 Gene

Domains & Families for RELL1 Gene

Gene Families for RELL1 Gene

Protein Domains for RELL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RELL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUW5

UniProtKB/Swiss-Prot:

RELL1_HUMAN :
  • Belongs to the RELT family.
Family:
  • Belongs to the RELT family.
genes like me logo Genes that share domains with RELL1: view

Function for RELL1 Gene

Phenotypes for RELL1 Gene

GenomeRNAi human phenotypes for RELL1:
genes like me logo Genes that share phenotypes with RELL1: view

Animal Model Products

CRISPR Products

miRNA for RELL1 Gene

miRTarBase miRNAs that target RELL1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RELL1 Gene

Localization for RELL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RELL1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RELL1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RELL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0015630 microtubule cytoskeleton IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RELL1: view

Pathways & Interactions for RELL1 Gene

SuperPathways for RELL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RELL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RELL1 Gene

Transcripts for RELL1 Gene

mRNA/cDNA for RELL1 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RELL1 Gene

RELT-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RELL1 Gene

No ASD Table

Relevant External Links for RELL1 Gene

GeneLoc Exon Structure for
RELL1
ECgene alternative splicing isoforms for
RELL1

Expression for RELL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RELL1 Gene

Protein differential expression in normal tissues from HIPED for RELL1 Gene

This gene is overexpressed in Adrenal (24.6), Gallbladder (8.7), and Spinal cord (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RELL1 Gene



Protein tissue co-expression partners for RELL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RELL1 Gene:

RELL1

SOURCE GeneReport for Unigene cluster for RELL1 Gene:

Hs.283378

mRNA Expression by UniProt/SwissProt for RELL1 Gene:

Q8IUW5-RELL1_HUMAN
Tissue specificity: Widely expressed. Expressed at highest levels in the placenta, skeletal muscle, spleen and testis.

Evidence on tissue expression from TISSUES for RELL1 Gene

  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with RELL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RELL1 Gene

Orthologs for RELL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RELL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RELL1 34 35
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia RELL1 34 35
  • 85.98 (n)
cow
(Bos Taurus)
Mammalia RELL1 34 35
  • 84.75 (n)
mouse
(Mus musculus)
Mammalia Rell1 34 16 35
  • 82.41 (n)
rat
(Rattus norvegicus)
Mammalia Rell1 34
  • 82.41 (n)
oppossum
(Monodelphis domestica)
Mammalia RELL1 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RELL1 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves RELL1 34 35
  • 67.95 (n)
lizard
(Anolis carolinensis)
Reptilia RELL1 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rell1 34
  • 61.25 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC799556 34
  • 59.51 (n)
RELL1 35
  • 42 (a)
OneToOne
Species where no ortholog for RELL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RELL1 Gene

ENSEMBL:
Gene Tree for RELL1 (if available)
TreeFam:
Gene Tree for RELL1 (if available)

Paralogs for RELL1 Gene

Paralogs for RELL1 Gene

(1) SIMAP similar genes for RELL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RELL1: view

Variants for RELL1 Gene

Sequence variations from dbSNP and Humsavar for RELL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000029752 -- 37,611,878(+) TATAT(A/G)AGAAG intron-variant, utr-variant-3-prime
rs1000063612 -- 37,613,450(+) TTCTT(A/G)CCCTG intron-variant
rs1000066209 -- 37,623,114(+) TACTT(C/T)TTAAA intron-variant
rs1000073935 -- 37,663,880(+) AGGCC(C/T)TTAAA intron-variant
rs1000090217 -- 37,656,077(+) TTAGT(C/T)ACAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RELL1 Gene

Variant ID Type Subtype PubMed ID
esv2727432 CNV deletion 23290073
esv2727433 CNV deletion 23290073
esv2727434 CNV deletion 23290073
esv2727435 CNV deletion 23290073
esv2727436 CNV deletion 23290073
esv2727437 CNV deletion 23290073
esv3332446 CNV duplication 20981092
esv3444544 CNV duplication 20981092
esv3600248 CNV loss 21293372
esv3600250 CNV loss 21293372
nsv1131785 CNV deletion 24896259
nsv4303 CNV insertion 18451855
nsv475765 CNV novel sequence insertion 20440878
nsv822535 CNV loss 20364138
nsv829909 CNV loss 17160897
nsv997413 CNV gain 25217958

Variation tolerance for RELL1 Gene

Residual Variation Intolerance Score: 64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RELL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RELL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RELL1 Gene

Disorders for RELL1 Gene

Relevant External Links for RELL1

Genetic Association Database (GAD)
RELL1
Human Genome Epidemiology (HuGE) Navigator
RELL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RELL1

No disorders were found for RELL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RELL1 Gene

Publications for RELL1 Gene

  1. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. (PMID: 16389068) Cusick J.K. … Shu H.-B. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 64
  2. Identification of PLSCR1 as a protein that interacts with RELT family members. (PMID: 22052202) Cusick J.K. … Reyland M.E. (Mol. Cell. Biochem. 2012) 2 3 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for RELL1 Gene

Sources for RELL1 Gene

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