RELL1 Gene
protein-coding GIFtS: 41
GCID: GC04M037592
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RELT-like 1
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Aliases
for RELL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RELT-Like 11 2 | | Receptor Expressed In Lymphoid Tissues Like 12 | | RELT-Like Protein 12 | | Tmp_locus_291 |
Export aliases for RELL1 gene to outside databasesPrevious GC identifers: GC00U922272 GC04U900697 GC04M037269 GC04M036916 |
Summaries
for RELL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RELL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016297.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RELL1 gene promoter:
Egr-3 HSF1 (long) AP-2gamma GATA-2 HNF-1 AP-2beta HSF1short AP-2alpha Pax-4a AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for RELL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RELL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p14 Ensembl cytogenetic band: 4p14 HGNC cytogenetic band: 4p14RELL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M037592: view genomic region
(about GC identifiers)
Start:
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37,592,422 bp from pter |
End:
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37,687,999 bp from pter |
Size:
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95,578 bases |
Orientation:
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minus strand |
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Proteins
for RELL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RELL1_HUMAN, Q8IUW5 (See
protein sequence)Recommended Name: RELT-like protein 1 precursor Size: 271 amino acids; 29340 Da
Subunit: Interacts with RELT, RELL2 and OXSR1
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q8NBK1Explore the universe of human proteins at neXtProt for RELL1: NX_Q8IUW5
Post-translational modifications:
Phosphorylated in vitro by OXSR11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IUW5
RELL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001078868.1 NP_001078869.1
ENSEMBL proteins: ENSP00000313385 ENSP00000398778 ENSP00000424031
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RELL1 for ontologies About GeneDecksing
RELL1 Antibody Products:
Assay Products for RELL1: |
Protein
Domains /
Families
for RELL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RELL1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IUW5ProtoNet protein and cluster: Q8IUW5 UniProtKB/Swiss-Prot: RELL1_HUMAN, Q8IUW5Similarity: Belongs to the RELT family |
Function
for RELL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RELL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RELL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RELL1 (NM_001085400) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RELL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELL1 |
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Pathways & Interactions
for RELL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RELL1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for RELL1 (Q8IUW53 ENSP000003133854) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for RELL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RELL1
Search CenterWatch for drugs/clinical trials and news about RELL1
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Transcripts
for RELL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RELL1 gene (2 alternative transcripts): NM_001085399.1 NM_001085400.1 Unigene Cluster for RELL1: RELT-like 1 Hs.283378 [show with all ESTs]Unigene Representative Sequence: NM_0010854003 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000314117(uc003gsz.2) ENST00000454158(uc010ifc.3) ENST00000512114
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RELL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RELL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RELL1 (NM_001085400) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RELL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELL1 |
Additional cDNA sequence: AK025431.1 AK075468.1 BC039540.1 6 DOTS entries: DT.100012236 DT.114021 DT.97773422 DT.91643146 DT.95370214 DT.40191614
GeneLoc Exon Structure
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Expression
for RELL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RELL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAATTTTTA
About this image
See RELL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RELL1
SOURCE GeneReport for Unigene cluster: Hs.283378
UniProtKB/Swiss-Prot: RELL1_HUMAN, Q8IUW5Tissue specificity: Widely expressed. Expressed at highest levels in the placenta, skeletal muscle, spleen and testis
SABiosciences Custom PCR Arrays for RELL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RELL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RELL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RELL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RELL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELL1 |
Orthologs
for RELL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RELL1 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for RELL1 (if available)
TreeFam Gene Tree for RELL1 (if available) |
Paralogs
for RELL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RELL1 gene
- RELT2 RELL22
1 SIMAP similar gene for RELL1 using alignment to 2 protein entries: RELL1_HUMAN (see all proteins):RELL2
RELL1 for paralogs About GeneDecksing
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Genomic Variants
for RELL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for RELL1
4 CNVs: 80249 80248 92046 92045 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RELL1 |
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Disorders
/ Diseases
for RELL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RELL1 for disorders About MalaCards
RELL1 for disorders About GeneDecksing
OMIM gene information: 611212
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: RELL1 (1 document)
Export disorders for RELL1 gene to outside databases
|
Publications
for RELL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RELL1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with RELL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. (PubMed id 16389068)1, 2, 3 Cusick J.K.... Shu H.-B. (2006)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- RELT induces cellular death in HEK 293 epithelial cel ls. (PubMed id 19969290)1 Cusick J.K....Reyland M.E. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
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External Searches for RELL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RELL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing RELL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RELL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RELL1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for RELL1 gene:
Search GeneIP for patents involving RELL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RELL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RELL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RELL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RELL1 | | | OriGene Protein Over-expression Lysate for RELL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RELL1 | | OriGene 3'-UTR Clone for RELL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RELL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RELL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RELL1 | | OriGene Custom Protein Services for RELL1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RELL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RELL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RELL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RELL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RELL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RELL1 |
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| | | | Search Tocris compounds for RELL1 |
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 | | | RELL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for RELL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELL1 |
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