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RELB Gene

protein-coding   GIFtS: 68

GC19P050196
v-rel reticuloendotheliosis viral oncogene homolog B
(Previous name: v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for RELB

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
I-REL 2
I-Rel 3
IREL 2, 5
Descriptions
reticuloendotheliosis viral oncogene homolog B 2
v-rel avian reticuloendotheliosis viral oncogene homolog B
(nuclear factor of kappa light polypeptide gene enhancer
in B-cells 3) 1, 2
v-rel reticuloendotheliosis viral oncogene homolog B 2
v-rel reticuloendotheliosis viral oncogene homolog B,
nuclear factor of kappa light polypeptide gene enhancer in
B-cells 3 2
External Ids
HGNC: 99561
Entrez Gene: 59712
UniProtKB: Q012013
Ensembl: ENSG000001048567
Search outside databases for aliases for RELB gene

Previous GC identifers: GC19P046149 GC19P045895 GC19P050180

Summaries
for RELB

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RELB_HUMAN, Q01201
Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell
types and is involved in many biological processed such as inflammation, immunity,
differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric
complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the
individual dimers have distinct preferences for different kappa-B sites that they can bind with
distinguishable affinity and specificity. Different dimer combinations act as transcriptional
activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of
post-translational modification and subcellular compartmentalization as well as by interactions
with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an
inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a
conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in
response to different activators, subsequently degraded thus liberating the active NF-kappa-B
complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52
complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or
REL. Stimulates promoter activity in the presence of NFKB2/p49

Genomic Location
for RELB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RELB gene  

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

RELB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050196:     (about GC identifiers)

Start:
 50,196,539 bp from pter
End:
 50,233,292 bp from pter
Size:
 36,754 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000019.8  NT_011109.15  

Proteins
for RELB

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: RELB_HUMAN, Q01201 (See protein sequence)
Recommended Name: Transcription factor RelB  
Size: 579 amino acids; 62134 Da
Subunit: Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52
complex. Self-associates; the interaction seems to be transient and may prevent degradation
allowing for heterodimer formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and
NFKB2/p100. Interacts with NFKBID (By similarity)
Subcellular location: Nucleus
Caution: Was originally (PubMed:1577270) thought to inhibit the transcriptional activity of nuclear
factor NF-kappa-B
Secondary accessions: Q6GTX7 Q9UEI7

Post-translational modifications:

  • Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation (By similarity)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_006500.2  

    ENSEMBL proteins: 
    ENSP00000221452 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Rel B)
    Human Recombinant Proteins from Abnova (RELB)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for RELB: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RELB
    R&D Systems Antibodies for RELB
    Cell Signaling Technology (CST) Antibodies for RELB 
    Antibodies from Abcam (Rel B), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (RELB)
    Novus Biologicals Antibody for RELB

    Assays for RELB: 
    Browse Invitrogen for biochemical assays
    Millipore Kits and Assays for the Analysis of RELB
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for RELB

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro domains/families:
     IPR002909 IPT_TIG_rcpt
     IPR013783 Ig-like_fold
     IPR000451 NF_Rel_dor
     IPR011539 RHD


       GeneDecks  RELB for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q01201

    ProtoNet protein and cluster: Q01201

    3 Blocks protein families:
    IPB000451 NF-kappa-B/Rel/dorsal family
    IPB002909 Cell surface receptor IPT/TIG
    IPB011539 Rel homology


    UniProtKB/Swiss-Prot: RELB_HUMAN, Q01201
    Domain: Both N- and C-terminal domains are required for transcriptional activation
    Similarity: Contains 1 RHD (Rel-like) domain

    Gene Function
    for RELB

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (RELB)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RELB)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006509

                  Applied Biosystems Silencer® siRNAs for RELB

                  Sigma-Aldrich siRNA for RELB  
                         Sigma-Aldrich shRNA Panels and shRNA for RELB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RELB
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_006509
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_006509
                                     untagged cDNA clone in CMV expression vector: NM_006509 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_006509

    UniProtKB/Swiss-Prot: RELB_HUMAN, Q01201
    Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell
    types and is involved in many biological processed such as inflammation, immunity,
    differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric
    complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
    REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the
    individual dimers have distinct preferences for different kappa-B sites that they can bind with
    distinguishable affinity and specificity. Different dimer combinations act as transcriptional
    activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of
    post-translational modification and subcellular compartmentalization as well as by interactions
    with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an
    inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a
    conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in
    response to different activators, subsequently degraded thus liberating the active NF-kappa-B
    complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52
    complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or
    REL. Stimulates promoter activity in the presence of NFKB2/p49
    Induction: By mitogens

    15 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Relb):

    behavior/neurologicaldigestive/alimentaryendocrine/exocrine glandgrowth/size
    hematopoietic systemhomeostasis/metabolismimmune systemlife span-post-weaning/agingliver/biliary system
    muscleotherreproductive systemrespiratory systemskin/coat/nails

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 transcription factor activity TAS8188306
    GO:0003714 transcription corepressor activity TAS1577270
    GO:0005515 protein binding IPI15799966
    About this table

    Pathways & Interactions
    for RELB

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5/40 Invitrogen iPath™ Online BioAtlas - Pathways for RELB (see all 40 ) (Maps provided by GeneGo):
     IL4 signaling pathway
     A2BR signaling via G-alpha-q: PRKCB/G/Q specific pathways (map 3a)
     Putative SUMO-1 pathway
     PDGF signaling via STATs and NF-kB
     TCR and CD28 co-stimulation in activation of NF-kB

       GeneDecks  RELB for the pathways selected above  
    About GeneDecksing

    5/40 Millipore Pathways for RELB (see all 40 )
     Immune response MIF-mediated glucocorticoid regulation
     Development TGF-beta receptor signaling
     Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
     Transcription NF-kB signaling pathway
     Transcription P53 signaling pathway

       GeneDecks  RELB for the pathways selected above  
    About GeneDecksing

    3 Sigma-Aldrich "Your Favorite Gene" Pathways for  RELB  (Your Favorite Gene powered by Ingenuity) 
     NF-&kappa
     Dendritic Cell Maturation
     Lymphotoxin &beta

       GeneDecks  RELB for the pathways selected above  
    About GeneDecksing

    1 Cell Signaling Technology (CST) Pathway for RELB: 
     NF-kB Signaling

       GeneDecks  RELB for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for RELB):
     hsa04010 MAPK signaling pathway

       GeneDecks  RELB for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  RELB 


    5/175 Interacting proteins for RELB (ENSP000002214523 Q012011, 2) via UniProtKB, MINT, and/or STRING (see all 175 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COMMD1Q8N6681STRING (score=.729) EBI-357837, EBI-1550112
    NFKB1P198382STRING (score=.982) MINT-48017 MINT-48562 MINT-6178544 MINT-48996 MINT-6178520 MINT-47912 MINT-48690 MINT-6178488
    NFKB2Q006532STRING (score=.996) MINT-49015 MINT-6178544 MINT-48631 MINT-48776 MINT-6178520 MINT-48018 MINT-47926 MINT-6178488
    BCL3P207492STRING (score=.989) MINT-6178520 MINT-6178488 MINT-6178544
    CHUKO151112STRING (score=.998) MINT-48981
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0019882 antigen processing and presentation IEA--
    GO:0043011 myeloid dendritic cell differentiation IEA--
    GO:0045063 T-helper 1 cell differentiation IEA--
    About this table

    Drugs & Compounds
    for RELB

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for RELB
    Browse Small Molecules at Sigma-Aldrich

    Compounds for RELB available from Tocris Bioscience

    Transcripts
    for RELB

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (RELB)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RELB)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006509

                  Sigma-Aldrich siRNA for RELB  
                         Sigma-Aldrich shRNA Panels and shRNA for RELB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_006509  

    REFSEQ mRNAs for RELB gene: 

    NM_006509.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_006509  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_006509
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_006509
                                     untagged cDNA clone in CMV expression vector: NM_006509 

    Additional cDNA sequence: 

    AK290594.1 BC028013.1 CR607370.1 M83221.1 

    5 DOTS entries:

    DT.100752175  DT.100860854  DT.100690152  DT.95161974  DT.75196529 

    24/87 AceView cDNA sequences (see all 87 ):

    AI738667 BM550511 BM930071 BI908595 BC028013 CR607370 BU179562 AI393279 
    AI676030 BE397094 AJ714299 BQ924660 NM_006509 AA258880 AI923086 CB529212 
    BM684710 BG748809 AI831842 BM723531 BX328312 M83221 AW206241 BX372372 

    highest scoring ESTs for RELB:

    AA043591 AA258001 AA258760 AA258880 AA258944 AA582859 AA745994 AI079286 AI253220 AI311812 

    Unigene Cluster for RELB:

    V-rel reticuloendotheliosis viral oncogene homolog B
    Hs.654402  [show with all ESTs]
    Unigene Representative Sequence: M83221


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RELB

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:              -           -                                                                     
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                          -     -               

    About this scheme

    ECgene alternative splicing isoforms for RELB

    1 Ensembl transcript including schematic representation:
    ENST00000221452  

    Expression
    for RELB

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RELB expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RELB

    1 / 2 / 3

    3 probe-sets matching RELB gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    570_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M83221 0.80 1.00 0.91 1

    		205205_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006509 0.60 1.00 0.82 1

    		205205_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  RELB for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGGGGGCACC

    SOURCE GeneReport for Unigene cluster: Hs.654402

    Expression variation in blood from EXPOLDB for RELB

    Orthologs
    for RELB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for RELB gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 RELB1   -- v-rel reticuloendotheliosis viral oncogene homolog more 89.97(n)
    93.71(a)    		 484454  XM_541569.2  XP_541569.2 
    chimpanzee
    (Pan troglodytes)    		 RELB1   -- v-rel reticuloendotheliosis viral oncogene homolog more 99.54(n)
    99.65(a)    		 456119  XM_512742.2  XP_512742.2 
    cow
    (Bos taurus)    		 RELB1   -- v-rel reticuloendotheliosis viral oncogene homolog more 88.7(n)
    92.7(a)    		 522670  XM_600955.3  XP_600955.3 
    mouse
    (Mus musculus)    		 Relb1, 5 7 (4.00 cM)5
    		 avian reticuloendotheliosis viral (v-rel) oncogene more1, 5 84.59(n)1
    89.93(a)1    		 196981  NM_009046.21  NP_033072.21 
     AK1469325  AK1567675  (see all 15)
    chicken
    (Gallus gallus)    		 RELB1   -- v-rel reticuloendotheliosis viral oncogene homolog more 65.63(n)
    64.52(a)    		 395656  NM_204850.1  NP_990181.1 
    About this table        Species with no ortholog for RELB

    ENSEMBL Gene Tree for RELB

    Paralogs
    for RELB

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RELB gene
    NFKB12  REL2  NFKB22  RELA2  

    SNPs/Variants
    for RELB

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/282 NCBI SNPs in RELB are shown (see all 282 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 70)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs355775631,2
    		C,F50196189(+) CCCTGG/CCAACC 1 -- ng512Minor allele frequency- C:0.47NS 92
    --
    rs72516551,2
    		A,C50194648(+) gaaccC/Tgggag 1 -- ng510--------
    --
    rs343007221,2
    		F50195929(+) CGGCCT/ACCCAA 1 -- ng512Minor allele frequency- A:0.08NS 94
    --
    rs116674661,2
    		H50195183(+) tcatcA/Tcagct 1 -- ng514Minor allele frequency- T:0.00EU EA WA 418
    --
    rs344151221,2
    		F50195353(+) TGGCAT/-CCAAC 1 -- ng512Minor allele frequency- -:0.05NS 94
    --
    rs22306821,2
    		F50229619(+) AACCAC/TGGCTC 1 H/H syn1 ese34Minor allele frequency- T:0.02MN NA NS 234
    rs8747431,2
    		A,C,F,H,O50205076(-) AAGTAC/TCTTAG 1 -- int18Minor allele frequency- T:0.14EU EA WA NA 778
    rs48037891,2
    		A,C,F,H50215209(+) TAAGAG/TTAAAG 1 -- int14Minor allele frequency- T:0.25EU EA WA 416
    rs104240461,2
    		A,C,F,H50227876(+) CCCACC/GACCTC 1 -- int114Minor allele frequency- G:0.43EU EA WA NA NS 1142
    rs65091771,2
    		A,C,F,H50221846(+) gtcccA/Gtggcc 1 -- int19Minor allele frequency- G:0.43EU EA WA NA NS 624
    About this table

    HapMap Linkage Disequilibrium images for RELB (up to first 250kb)

    Disorders & Mutations
    for RELB

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 604758

    6 Novoseek disease relationships for RELB gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 21.44 6 9681829 (1), 12897145 (1), 18955032 (1)
    necrosis 21.15 1 10227387 (1)
    prostate cancer 15.27 11 16261162 (6), 19351823 (4)
    inflammation 6.96 9 9250151 (3), 18955032 (1)
    tumors 4.79 8 19351823 (3), 10227387 (1), 12897145 (1), 16740744 (1)
    cancer 0.00 1 16205698 (1)
    About this table

    Human Genome Epidemiology Navigator: RELB (3 documents)

    Medical News
    for RELB

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for RELB

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		16/153 PubMed articles for RELB gene (see all 153 ):

    Search for RELB

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Search String
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RELB

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 5971 HGNC: 9956 AceView: RELB Ensembl:ENSG00000104856 euGenes: HUgn5971
    ECgene: RELB H-InvDB: RELB

    Other Databases showing RELB

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing RELB

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for RELB Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for RELB

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for RELB

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RELB:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RELB-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for RELB Antibodies for RELB
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for RELB Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (RELB)
     Antibodies (RELB)
     Chimera RNAi (RELB)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Antibodies & Assays for RELB 

     Recombinant Proteins
    (Rel B)
     Antibodies (Rel B)
     Search OriGene for RELB
     Tocris compounds for RELB




     Drugs for RELB
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for RELB

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    RELB Gene at Home site.
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