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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RELB Gene

protein-coding   GIFtS: 64
GCID: GC19P045504

V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog...

(Previous name: v-rel avian reticuloendotheliosis viral oncogene homolog...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B1 2     REL-B2
V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B (Nuclear Factor
Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3)1 2
     Transcription Factor RelB2
IREL2 5     V-Rel Reticuloendotheliosis Viral Oncogene Homolog B, Nuclear Factor Of
Kappa Light Polypeptide Gene Enhancer In B-Cells 32
I-REL2     I-Rel3

External Ids:    HGNC: 99561   Entrez Gene: 59712   Ensembl: ENSG000001048567   OMIM: 6047585   UniProtKB: Q012013   

Export aliases for RELB gene to outside databases

Previous GC identifers: GC19P046149 GC19P045895 GC19P050180 GC19P050196 GC19P041935


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RELB Gene: 
RELB (v-rel avian reticuloendotheliosis viral oncogene homolog B) is a protein-coding gene. Diseases associated with RELB include severe acute respiratory syndrome, and neurologic diseases, and among its related super-pathways are Signal transduction AKT signaling and Mucin expression in CF via IL-6, IL-17 signaling pathways. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFKB1.

UniProtKB/Swiss-Prot: RELB_HUMAN, Q01201
Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is
involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis
and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins
RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their
target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind
with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or
repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and
subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B
complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor
(I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs)
in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which
translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional
activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the
presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal
adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment

Gene Wiki entry for RELB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RELB gene promoter:
         GR   AP-1   GR-beta   ATF-2   STAT3   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRELB promoter sequence
   Search SABiosciences Chromatin IP Primers for RELB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RELB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

RELB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RELB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045504:  view genomic region     (about GC identifiers)

Start:
45,504,688 bp from pter      End:
45,541,456 bp from pter
Size:
36,769 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RELB_HUMAN, Q01201 (See protein sequence)
Recommended Name: Transcription factor RelB  
Size: 579 amino acids; 62134 Da
Subunit: Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex.
Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer
formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID (By
similarity)
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Note=Co-localizes with NEK6 in the centrosome
Caution: Was originally (PubMed:1577270) thought to inhibit the transcriptional activity of nuclear factor
NF-kappa-B
Secondary accessions: Q6GTX7 Q9UEI7

Explore the universe of human proteins at neXtProt for RELB: NX_Q01201

Explore proteomics data for RELB at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01201

  • RELB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RELB Protein Expression
    REFSEQ proteins: NP_006500.2  
    ENSEMBL proteins: 
     ENSP00000221452   ENSP00000427348   ENSP00000423287   ENSP00000468460   ENSP00000445542  

    Human Recombinant Protein Products for RELB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RELB
    OriGene Protein Over-expression Lysate for RELB
    OriGene MassSpec for RELB 
    OriGene Custom Protein Services for RELB
    GenScript Custom Purified and Recombinant Proteins Services for RELB
    Novus Biologicals RELB Protein
    Novus Biologicals RELB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RELB 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol IEA--

    RELB for ontologies           About GeneDecksing



    RELB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RELB
    R&D Systems Antibodies for RELB
    Cell Signaling Technology (CST) Antibodies for RELB 
    OriGene Antibodies for RELB
    OriGene Custom Antibody Services for RELB
    GenScript Custom Superior Antibodies Services for RELB
    Novus Biologicals RELB Antibodies
    Abcam antibodies for RELB
    Cloud-Clone Corp. Antibodies for RELB 
    ThermoFisher Antibody for RELB
    LSBio Antibodies in human, mouse, rat for RELB 

    Assay Products for RELB: 
    EMD Millipore Kits and Assays for the Analysis of RELB
    OriGene Custom Assay Services for RELB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RELB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RELB 
    Cloud-Clone Corp. CLIAs for RELB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR014756 Ig_E-set
     IPR008967 p53-like_TF_DNA-bd
     IPR002909 IPT_TIG_rcpt
     IPR013783 Ig-like_fold
     IPR000451 NF_Rel_Dor

    Graphical View of Domain Structure for InterPro Entry Q01201

    ProtoNet protein and cluster: Q01201

    3 Blocks protein domains:
    IPB000451 NF-kappa-B/Rel/dorsal family
    IPB002909 Cell surface receptor IPT/TIG
    IPB011539 Rel homology


    UniProtKB/Swiss-Prot: RELB_HUMAN, Q01201
    Domain: Both N- and C-terminal domains are required for transcriptional activation
    Similarity: Contains 1 RHD (Rel-like) domain


    RELB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RELB_HUMAN, Q01201
    Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is
    involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis
    and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins
    RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their
    target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind
    with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or
    repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and
    subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B
    complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor
    (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs)
    in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which
    translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional
    activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the
    presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal
    adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment
    Induction: Up-regulated by mitogens and NUPR1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity TAS1577270
    GO:0005515protein binding IPI15799966
         
    RELB for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RELB:
     Increased G1 DNA content  Increased cell number in G1, a 

         15/17 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Relb) (see all 17):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  muscle  other 

    RELB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Relbtm1Brv for RELB

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RELB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RELB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RELB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RELB 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RELB
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate RELB:
    hsa-miR-548am hsa-miR-548x hsa-miR-616* hsa-miR-7 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidRELB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RELB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RELB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RELB
    Sirion Biotech Customized adenovirus for overexpression of RELB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RELB (see all 7)
    OriGene ORF clones in mouse, rat for RELB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RELB (NM_006509)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RELB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELB
    Sirion Biotech Customized lentivirus for stable overexpression of RELB 
                         Customized lentivirus expression plasmids for stable overexpression of RELB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RELB
    Search LifeMap BioReagents cell lines for RELB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RELB About   (see all 47)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Mucin expression in CF via IL-6, IL-17 signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways0.48
    Mucin expression in CF via TLRs, EGFR signaling pathways0.41
    IL-17 Signaling0.48
    3Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    4Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.91
    Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
    5TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    TWEAK Signaling Pathway0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/40 EMD Millipore Pathways for RELB (see all 40)
        Immune response MIF-mediated glucocorticoid regulation
    Development TGF-beta receptor signaling
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Transcription NF-kB signaling pathway
    Transcription P53 signaling pathway

    5/6 R&D Systems Pathways for RELB (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RELB
        LT-BetaR Pathway
    NF-KappaB Family Pathway

    1 Cell Signaling Technology (CST) Pathway for RELB
        NF-kappaB Signaling

    5/47 GeneGo (Thomson Reuters) Pathways for RELB (see all 47)
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Development A2A receptor signaling
    Immune response Bacterial infections in normal airways
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    5/6 BioSystems Pathways for RELB (see all 6)
        TNF-alpha/NF-kB Signaling Pathway
    RANKL/RANK Signaling Pathway
    TWEAK Signaling Pathway
    TSLP Signaling Pathway
    Alternative NF-kappaB pathway

    1 PharmGKB Pathway for RELB
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    5         Kegg Pathways  (Kegg details for RELB):
        MAPK signaling pathway
    NF-kappa B signaling pathway
    Osteoclast differentiation
    HTLV-I infection
    Epstein-Barr virus infection


    RELB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RELB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/139 Interacting proteins for RELB (Q012011, 2, 3 ENSP000002214524) via UniProtKB, MINT, STRING, and/or I2D (see all 139)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB2Q006532, 3, ENSP000001894444MINT-49015 MINT-6178544 MINT-48631 MINT-48776 MINT-6178520 MINT-48018 MINT-47926 MINT-6178488 I2D: score=8 STRING: ENSP00000189444
    NFKB1P198382, 3, ENSP000002265744MINT-48017 MINT-48562 MINT-6178544 MINT-48996 MINT-6178520 MINT-47912 MINT-48690 MINT-6178488 I2D: score=7 STRING: ENSP00000226574
    ENSG00000183311P074372, 3MINT-49010 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49010 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49010 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0010628positive regulation of gene expression IEA--
    GO:0019882antigen processing and presentation IEA--
    GO:0042088T-helper 1 type immune response ----

    RELB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RELB

    Search CenterWatch for drugs/clinical trials and news about RELB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RELB gene: 
    NM_006509.3  

    Unigene Cluster for RELB:

    V-rel reticuloendotheliosis viral oncogene homolog B
    Hs.654402  [show with all ESTs]
    Unigene Representative Sequence: M83221
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221452(uc021uvp.1 uc021uvq.1) ENST00000509480 ENST00000505236
    ENST00000510184 ENST00000509229 ENST00000589972 ENST00000540120
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RELB
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate RELB:
    hsa-miR-548am hsa-miR-548x hsa-miR-616* hsa-miR-7 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidRELB 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RELB
    Clone
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    GenScript: all cDNA clones in your preferred vector: RELB (NM_006509)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RELB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELB
    Sirion Biotech Customized lentivirus for stable overexpression of RELB 
                         Customized lentivirus expression plasmids for stable overexpression of RELB 
    Primer
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    OriGene qPCR primer pairs and template standards for RELB
    OriGene qSTAR qPCR primer pairs in human, mouse for RELB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RELB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RELB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RELB

    Additional mRNA sequence: 

    AK290594.1 BC028013.1 M83221.1 

    5 DOTS entries:

    DT.100752175  DT.100860854  DT.100690152  DT.95161974  DT.75196529 

    24/87 AceView cDNA sequences (see all 87):

    BI908595 AI676030 NM_006509 BE397094 BC028013 AJ714299 BU179562 BQ924660 
    AI393279 BM930071 AI738667 CR607370 BM550511 BX372372 AL583128 AL583127 
    BX110471 AI831842 BX405015 AW206241 BX328312 BP339329 BG748809 BM457778 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RELB    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:              -           -                                                                     
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                          -     -               


    ECgene alternative splicing isoforms for RELB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RELB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGGGCACC
    RELB Expression
    About this image


    See RELB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RELB

    SOURCE GeneReport for Unigene cluster: Hs.654402
        SABiosciences Expression via Pathway-Focused PCR Arrays including RELB (see all 7): 
              NFKB Signaling Targets in human mouse rat
              Antigen Presenting Cells in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Transcription Factors in human mouse rat
              T Helper Cell Differentiation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RELB gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Relb1 , 5 avian reticuloendotheliosis viral (v-rel) oncogene more1, 5 84.59(n)1
    89.93(a)1
      7 (9.93 cM)5
    196981  NM_009046.21  NP_033072.21 
     196062175 
    chicken
    (Gallus gallus)
    Aves RELB1 v-rel reticuloendotheliosis viral oncogene homolog more 65.63(n)
    64.52(a)
      395656  NM_204850.1  NP_990181.1 
    lizard
    (Anolis carolinensis)
    Reptilia RELB6
    Uncharacterized protein
    58(a)
    1 ↔ 1
    LGf(3447292-3458483)
    African clawed frog
    (Xenopus laevis)
    Amphibia relb-A2 v-rel reticuloendotheliosis viral oncogene homolog more 76.96(n)    D63332.1 
    zebrafish
    (Danio rerio)
    Actinopterygii relb6
    v-rel reticuloendotheliosis viral oncogene homolog...
    36(a)
    1 ↔ 1
    15(16119749-16144236)
    fruit fly
    (Drosophila melanogaster)
    Insecta dl3 immune response transcription factor 45(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for RELB (if available)
    TreeFam Gene Tree for RELB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RELB gene
    NFKB12  REL2  NFKB22  RELA2  
    3 SIMAP similar genes for RELB using alignment to 4 protein entries:     RELB_HUMAN (see all proteins):
    RELA    REL    NFKB2

    RELB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/878 SNPs in RELB are shown (see all 878)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932965471,2
    --45502748(+) GCGCAG/TTGGCT 1 -- us2k10--------
    rs1839311961,2
    --45502806(+) TTGAAA/CCCGGG 1 -- us2k10--------
    rs72516551,2
    C,F,A,H--45502808(+) gaaccC/Tgggag 1 -- us2k12Minor allele frequency- T:0.50NA 6
    rs1401627121,2
    --45503059(+) GACACC/TCTGCC 1 -- us2k10--------
    rs1453853991,2
    C--45503198(+) GGTTTC/TAGTTT 1 -- us2k10--------
    rs735602251,2
    C,F--45503266(+) ATTCAA/GCTTAC 1 -- us2k13Minor allele frequency- G:0.17WA CSA 122
    rs116674661,2
    C,H--45503343(+) tcatcA/Tcagct 1 -- us2k15Minor allele frequency- T:0.00NS EA NA 424
    rs1864592741,2
    --45503344(+) CATCAC/GAGCTC 1 -- us2k10--------
    rs1913555471,2
    --45503382(+) GCAATC/TCTCCT 1 -- us2k10--------
    rs344151221,2
    C,F--45503513(+) TGGCAT/-CCAAC 1 -- us2k12Minor allele frequency- -:0.05NS 94

    HapMap Linkage Disequilibrium report for RELB (45504688 - 45541456 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RELB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912141CNV Loss21882294
    nsv912134CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604758    OMIM disorders: --

    20/33 diseases for RELB (see all 33):    About MalaCards
    severe acute respiratory syndrome    neurologic diseases    hiv type 1    kaposi's sarcoma
    pancreatic ductal adenocarcinoma    hodgkin's lymphoma    atopic dermatitis    nasopharyngitis
    peritonitis    dermatitis    multiple myeloma    non-hodgkin lymphoma
    breast cancer    myeloma    prostate cancer    astrocytoma
    chronic lymphocytic leukemia    sarcoma    prostatitis    tuberculosis


    RELB for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for RELB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 23.8 2 10227387 (1), 19549902 (1)
    breast cancer 17.7 6 9681829 (1), 12897145 (1), 18955032 (1)
    prostate cancer 11.4 11 16261162 (6), 19351823 (4)
    inflammation 7.25 10 9250151 (3), 19690169 (1), 18955032 (1)
    tumors 5.77 9 19351823 (3), 10227387 (1), 12897145 (1), 19549902 (1) (see all 5)
    cancer 0 2 19903458 (1), 16205698 (1)

    Genetic Association Database (GAD): RELB
    Human Genome Epidemiology (HuGE) Navigator: RELB (10 documents)

    Export disorders for RELB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RELB gene, integrated from 9 sources (see all 216):
    (articles sorted by number of sources associating them with RELB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif. (PubMed id 8441398)1, 2, 9 Dobrzanski P.... Bravo R. (1993)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. Association between anti-tumour necrosis factor treat ment response and genetic variants within the TLR and NF{kappa}B signalling pat hways. (PubMed id 20448286)1, 4 Potter C....Wilson A.G. (2010)
    4. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    5. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    6. Common genetic variants in candidate genes and risk o f familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (2009)
    7. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)
    8. Genetic variation in the NF{kappa}B pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 4 Dieguez-Gonzalez R....Gonzalez A. (2008)
    9. Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules. (PubMed id 18466468)1, 4 Liu-Mares W....Goode E.L. (2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5971 HGNC: 9956 AceView: RELB Ensembl:ENSG00000104856 euGenes: HUgn5971
    ECgene: RELB Kegg: 5971 H-InvDB: RELB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RELB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RELB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RELB gene:
    Search GeneIP for patents involving RELB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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