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Aliases for RELB Gene

Aliases for RELB Gene

  • RELB Proto-Oncogene, NF-KB Subunit 2
  • V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B (Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3) 2 3
  • V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B 3 5
  • I-REL 3 4
  • V-Rel Reticuloendotheliosis Viral Oncogene Homolog B, Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3 3
  • REL-B 3
  • IREL 3

External Ids for RELB Gene

Previous GeneCards Identifiers for RELB Gene

  • GC19P046149
  • GC19P045895
  • GC19P050180
  • GC19P050196
  • GC19P045504
  • GC19P041935

Summaries for RELB Gene

GeneCards Summary for RELB Gene

RELB (RELB Proto-Oncogene, NF-KB Subunit) is a Protein Coding gene. Among its related pathways are RANK Signaling in Osteoclasts and Development VEGF signaling via VEGFR2 - generic cascades. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is NFKB1.

UniProtKB/Swiss-Prot for RELB Gene

  • NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52.

Gene Wiki entry for RELB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RELB Gene

Genomics for RELB Gene

Regulatory Elements for RELB Gene

Enhancers for RELB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RELB on UCSC Golden Path with GeneCards custom track

Promoters for RELB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RELB on UCSC Golden Path with GeneCards custom track

Genomic Location for RELB Gene

Chromosome:
19
Start:
45,001,430 bp from pter
End:
45,038,198 bp from pter
Size:
36,769 bases
Orientation:
Plus strand

Genomic View for RELB Gene

Genes around RELB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RELB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RELB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RELB Gene

Proteins for RELB Gene

  • Protein details for RELB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01201-RELB_HUMAN
    Recommended name:
    Transcription factor RelB
    Protein Accession:
    Q01201
    Secondary Accessions:
    • Q6GTX7
    • Q9UEI7

    Protein attributes for RELB Gene

    Size:
    579 amino acids
    Molecular mass:
    62134 Da
    Quaternary structure:
    • Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex. Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID. Interacts with ARNTL/BMAL1 and the interaction is enhanced in the presence of CLOCK (By similarity).

neXtProt entry for RELB Gene

Proteomics data for RELB Gene at MOPED

Post-translational modifications for RELB Gene

  • Phosphorylation at Thr-103 and Ser-573 is followed by proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RELB Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RELB (RELB)

No data available for DME Specific Peptides for RELB Gene

Domains & Families for RELB Gene

Gene Families for RELB Gene

Graphical View of Domain Structure for InterPro Entry

Q01201

UniProtKB/Swiss-Prot:

RELB_HUMAN :
  • Both N- and C-terminal domains are required for transcriptional activation.
Domain:
  • Both N- and C-terminal domains are required for transcriptional activation.
  • Contains 1 RHD (Rel-like) domain.
genes like me logo Genes that share domains with RELB: view

Function for RELB Gene

Molecular function for RELB Gene

UniProtKB/Swiss-Prot Function:
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52.
UniProtKB/Swiss-Prot Induction:
Up-regulated by mitogens and NUPR1.

Gene Ontology (GO) - Molecular Function for RELB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,TAS 8188306
genes like me logo Genes that share ontologies with RELB: view
genes like me logo Genes that share phenotypes with RELB: view

Animal Models for RELB Gene

MGI Knock Outs for RELB:

Animal Model Products

miRNA for RELB Gene

miRTarBase miRNAs that target RELB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RELB Gene

Localization for RELB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RELB Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RELB Gene COMPARTMENTS Subcellular localization image for RELB gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 3
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RELB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RELB: view

Pathways & Interactions for RELB Gene

genes like me logo Genes that share pathways with RELB: view

SIGNOR curated interactions for RELB Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RELB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with RELB: view

Drugs & Compounds for RELB Gene

(3) Drugs for RELB Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
JSH-23 Pharma NF-κB inhibitor 0
QNZ (EVP4593) Pharma Potent NF-κB inhibitor 0
Triptolide Pharma IL-2/MMP-3/MMP7/MMP19 inhibitor, Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive 6

(3) ApexBio Compounds for RELB Gene

Compound Action Cas Number
JSH-23 NF-κB inhibitor 749886-87-1
QNZ (EVP4593) Potent NF-κB inhibitor 545380-34-5
Triptolide IL-2/MMP-3/MMP7/MMP19 inhibitor 38748-32-2
genes like me logo Genes that share compounds with RELB: view

Transcripts for RELB Gene

Unigene Clusters for RELB Gene

V-rel reticuloendotheliosis viral oncogene homolog B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RELB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2:
SP3:
SP4: - -

Relevant External Links for RELB Gene

GeneLoc Exon Structure for
RELB
ECgene alternative splicing isoforms for
RELB

Expression for RELB Gene

mRNA expression in normal human tissues for RELB Gene

mRNA differential expression in normal tissues according to GTEx for RELB Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for RELB Gene

This gene is overexpressed in Heart (27.2), Blymphocyte (19.2), and Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RELB Gene



SOURCE GeneReport for Unigene cluster for RELB Gene Hs.654402

genes like me logo Genes that share expression patterns with RELB: view

Protein tissue co-expression partners for RELB Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RELB Gene

Orthologs for RELB Gene

This gene was present in the common ancestor of animals.

Orthologs for RELB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RELB 35
  • 88.24 (n)
  • 91.52 (a)
RELB 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RELB 35
  • 89.7 (n)
  • 92.86 (a)
RELB 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Relb 35
  • 84.53 (n)
  • 89.75 (a)
Relb 16
Relb 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RELB 35
  • 99.54 (n)
  • 99.65 (a)
RELB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Relb 35
  • 83.27 (n)
  • 89.86 (a)
oppossum
(Monodelphis domestica)
Mammalia RELB 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RELB 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia relb 35
  • 59.66 (n)
  • 62.46 (a)
African clawed frog
(Xenopus laevis)
Amphibia relb-A 35
zebrafish
(Danio rerio)
Actinopterygii relb 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dif 37
  • 37 (a)
dl 37
  • 45 (a)
Dif 36
  • 14 (a)
ManyToMany
dl 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToOne
Species with no ortholog for RELB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RELB Gene

ENSEMBL:
Gene Tree for RELB (if available)
TreeFam:
Gene Tree for RELB (if available)

Paralogs for RELB Gene

Paralogs for RELB Gene

(3) SIMAP similar genes for RELB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RELB: view

Variants for RELB Gene

Sequence variations from dbSNP and Humsavar for RELB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2230682 - 45,034,521(+) AACCA(C/T)GGCTC reference, synonymous-codon
rs7257048 -- 45,017,027(+) ccagc(A/C)taact intron-variant
rs7257325 -- 45,017,298(+) CAAAA(A/T)TTCTG intron-variant
rs7507314 -- 45,029,988(+) catgg(C/T)gaaac intron-variant
rs12981350 -- 45,018,923(+) caccc(A/G/T)ccaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RELB Gene

Variant ID Type Subtype PubMed ID
nsv912134 CNV Loss 21882294
nsv912141 CNV Loss 21882294

Variation tolerance for RELB Gene

Residual Variation Intolerance Score: 9.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RELB Gene

Disorders for RELB Gene

Relevant External Links for RELB

Genetic Association Database (GAD)
RELB
Human Genome Epidemiology (HuGE) Navigator
RELB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RELB

No disorders were found for RELB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RELB Gene

Publications for RELB Gene

  1. Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif. (PMID: 8441398) Dobrzanski P. … Bravo R. (Mol. Cell. Biol. 1993) 3 4 23 67
  2. p52-Independent nuclear translocation of RelB promotes LPS-induced attachment. (PMID: 19903458) Saito T. … Longo D.L. (Biochem. Biophys. Res. Commun. 2010) 3 23
  3. Activation of noncanonical NF-kappaB signaling by the oncoprotein Tio. (PMID: 20353939) de Jong S.J. … Biesinger B. (J. Biol. Chem. 2010) 3 23
  4. RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke. (PMID: 18688039) Yang S.R. … Rahman I. (Am. J. Respir. Cell Mol. Biol. 2009) 3 23
  5. RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity. (PMID: 19351823) Xu Y. … St Clair W.H. (Cancer Res. 2009) 3 23

Products for RELB Gene

Sources for RELB Gene

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