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RELB Gene

protein-coding   GIFtS: 64
GCID: GC19P045504

V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog...

(Previous name: v-rel avian reticuloendotheliosis viral oncogene homolog...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B1 2     REL-B2
V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B (Nuclear Factor
Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3)1 2
     Transcription Factor RelB2
IREL2 5     V-Rel Reticuloendotheliosis Viral Oncogene Homolog B, Nuclear Factor Of
Kappa Light Polypeptide Gene Enhancer In B-Cells 32
I-REL2     I-Rel3

External Ids:    HGNC: 99561   Entrez Gene: 59712   Ensembl: ENSG000001048567   OMIM: 6047585   UniProtKB: Q012013   

Export aliases for RELB gene to outside databases

Previous GC identifers: GC19P046149 GC19P045895 GC19P050180 GC19P050196 GC19P041935


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RELB Gene:
RELB (v-rel avian reticuloendotheliosis viral oncogene homolog B) is a protein-coding gene. Diseases associated with RELB include severe acute respiratory syndrome, and neurologic diseases. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFKB1.

UniProtKB/Swiss-Prot: RELB_HUMAN, Q01201
Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is
involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis
and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins
RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their
target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind
with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or
repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and
subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B
complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor
(I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs)
in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which
translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional
activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the
presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal
adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment

Gene Wiki entry for RELB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RELB gene promoter:
         GR   AP-1   GR-beta   ATF-2   STAT3   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRELB promoter sequence
   Search Chromatin IP Primers for RELB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RELB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

RELB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RELB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045504:  view genomic region     (about GC identifiers)

Start:
45,504,688 bp from pter      End:
45,541,456 bp from pter
Size:
36,769 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RELB_HUMAN, Q01201 (See protein sequence)
Recommended Name: Transcription factor RelB  
Size: 579 amino acids; 62134 Da
Subunit: Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex.
Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer
formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID (By
similarity)
Caution: Was originally (PubMed:1577270) thought to inhibit the transcriptional activity of nuclear factor
NF-kappa-B
Secondary accessions: Q6GTX7 Q9UEI7

Explore the universe of human proteins at neXtProt for RELB: NX_Q01201

Explore proteomics data for RELB at MOPED

Post-translational modifications: 

  • Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RELB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006500.2  
    ENSEMBL proteins: 
     ENSP00000221452   ENSP00000427348   ENSP00000423287   ENSP00000468460   ENSP00000445542  

    RELB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RELB
    OriGene Protein Over-expression Lysate for RELB
    OriGene MassSpec for RELB
    OriGene Custom Protein Services for RELB
    GenScript Custom Purified and Recombinant Proteins Services for RELB
    Novus Biologicals RELB Protein
    Novus Biologicals RELB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RELB

    RELB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RELB
    R&D Systems Antibodies for RELB
    Cell Signaling Technology (CST) Antibodies for RELB 
    OriGene Antibodies for RELB
    OriGene Custom Antibody Services for RELB
    Novus Biologicals RELB Antibodies
    Abcam antibodies for RELB
    Cloud-Clone Corp. Antibodies for RELB
    ThermoFisher Antibody for RELB
    LSBio Antibodies in human, mouse, rat for RELB

    RELB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RELB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RELB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RELB
    Cloud-Clone Corp. CLIAs for RELB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR014756 Ig_E-set
     IPR008967 p53-like_TF_DNA-bd
     IPR002909 IPT
     IPR013783 Ig-like_fold
     IPR000451 NF_Rel_Dor

    Graphical View of Domain Structure for InterPro Entry Q01201

    ProtoNet protein and cluster: Q01201

    3 Blocks protein domains:
    IPB000451 NF-kappa-B/Rel/dorsal family
    IPB002909 Cell surface receptor IPT/TIG
    IPB011539 Rel homology


    UniProtKB/Swiss-Prot: RELB_HUMAN, Q01201
    Domain: Both N- and C-terminal domains are required for transcriptional activation
    Similarity: Contains 1 RHD (Rel-like) domain


    RELB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RELB_HUMAN, Q01201
    Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is
    involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis
    and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins
    RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their
    target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind
    with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or
    repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and
    subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B
    complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor
    (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs)
    in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which
    translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional
    activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the
    presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal
    adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment
    Induction: Up-regulated by mitogens and NUPR1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity TAS1577270
    GO:0005515protein binding IPI14743216
         
    RELB for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RELB:
     Increased G1 DNA content  Increased cell number in G1, a 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Relb) (see all 17):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  muscle  other 

    RELB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Relbtm1Brv for RELB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RELB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RELB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RELB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RELB

    miRNA
    Products:
        
    miRTarBase miRNAs that target RELB:
    hsa-mir-26b-5p (MIRT029940)

    Block miRNA regulation of human, mouse, rat RELB using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate RELB:
    hsa-miR-548am hsa-miR-548x hsa-miR-616* hsa-miR-7 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidRELB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RELB
    Predesigned siRNA for gene silencing in human, mouse, rat RELB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RELB

    Clone
    Products:
         
    OriGene clones in human, mouse for RELB (see all 6)
    OriGene ORF clones in mouse, rat for RELB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RELB (NM_006509)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RELB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RELB
    Browse ESI BIO Cell Lines and PureStem Progenitors for RELB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RELB_HUMAN, Q01201: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Note=Colocalizes with NEK6 in the centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol2
    mitochondrion2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol IEA--

    RELB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RELB About   (see all 40)  
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39
    3Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    Bacterial infections in CF airways0.78
    Transcription NF kB signaling pathway0.32
    4TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    TWEAK Signaling Pathway0.31
    5IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for RELB (see all 7)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RELB
        LT-BetaR Pathway
    NF-KappaB Family Pathway

    1 Cell Signaling Technology (CST) Pathway for RELB
        NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for RELB (see all 47)
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Development A2A receptor signaling
    Immune response Bacterial infections in normal airways
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    Selected BioSystems Pathways for RELB (see all 6)
        TNF-alpha/NF-kB Signaling Pathway
    TWEAK Signaling Pathway
    RANKL/RANK Signaling Pathway
    TSLP Signaling Pathway
    IL12-mediated signaling events

    1 PharmGKB Pathway for RELB
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for RELB):
        MAPK signaling pathway
    NF-kappa B signaling pathway
    Osteoclast differentiation
    HTLV-I infection
    Epstein-Barr virus infection


    RELB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RELB (see all 7): 
              NFKB Signaling Targets in human mouse rat
              Antigen Presenting Cells in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Transcription Factors in human mouse rat
              T Helper Cell Differentiation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RELB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RELB (Q012011, 2, 3 ENSP000002214524) via UniProtKB, MINT, STRING, and/or I2D (see all 157)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB2Q006531, 2, 3, ENSP000001894444EBI-357837,EBI-307326 MINT-49015 MINT-6178544 MINT-48631 MINT-48776 MINT-6178520 MINT-48018 MINT-47926 MINT-6178488 I2D: score=8 STRING: ENSP00000189444
    NFKB1P198381, 2, 3, ENSP000002265744EBI-357837,EBI-300010 MINT-48017 MINT-48562 MINT-6178544 MINT-48996 MINT-6178520 MINT-47912 MINT-48690 MINT-6178488 I2D: score=7 STRING: ENSP00000226574
    ENSG00000183311P074372, 3MINT-49010 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49010 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49010 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0010628positive regulation of gene expression IEA--
    GO:0019882antigen processing and presentation IEA--
    GO:0042088T-helper 1 type immune response ----

    RELB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RELB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RELB gene: 
    NM_006509.3  

    Unigene Cluster for RELB:

    V-rel reticuloendotheliosis viral oncogene homolog B
    Hs.654402  [show with all ESTs]
    Unigene Representative Sequence: M83221
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221452(uc021uvp.1 uc021uvq.1) ENST00000509480 ENST00000505236
    ENST00000510184 ENST00000509229 ENST00000589972 ENST00000540120
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RELB using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate RELB:
    hsa-miR-548am hsa-miR-548x hsa-miR-616* hsa-miR-7 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidRELB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RELB
    Predesigned siRNA for gene silencing in human, mouse, rat RELB
    Clone
    Products:
         
    OriGene clones in human, mouse for RELB (see all 6)
    OriGene ORF clones in mouse, rat for RELB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RELB (NM_006509)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RELB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RELB
    OriGene qSTAR qPCR primer pairs in human, mouse for RELB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RELB
      QuantiTect SYBR Green Assays in human, mouse, rat RELB
      QuantiFast Probe-based Assays in human, mouse, rat RELB

    Additional mRNA sequence: 

    AK290594.1 BC028013.1 M83221.1 

    5 DOTS entries:

    DT.100752175  DT.100860854  DT.100690152  DT.95161974  DT.75196529 

    Selected AceView cDNA sequences (see all 87):

    BC028013 AI676030 BM930071 BU179562 AI393279 BI908595 NM_006509 AI738667 
    BM550511 CR607370 AJ714299 BQ924660 BE397094 BM457778 BM684710 AL583127 
    AA258880 BX110471 M83221 AA258001 BQ182894 BX372372 BM763946 AL583128 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RELB    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:              -           -                                                                     
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                          -     -               


    ECgene alternative splicing isoforms for RELB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RELB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGGGCACC
    RELB Expression
    About this image

    RELB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RELB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654402
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RELB (see all 7): 
              NFKB Signaling Targets in human mouse rat
              Antigen Presenting Cells in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Transcription Factors in human mouse rat
              T Helper Cell Differentiation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RELB
    OriGene qSTAR qPCR primer pairs in human, mouse for RELB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RELB
    QuantiTect SYBR Green Assays in human, mouse, rat RELB
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RELB gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Relb1 , 5 avian reticuloendotheliosis viral (v-rel) oncogene more1, 5 84.53(n)1
    89.75(a)1
      7 (9.93 cM)5
    196981  NM_009046.21  NP_033072.21 
     196062175 
    lizard
    (Anolis carolinensis)
    Reptilia RELB6
    v-rel avian reticuloendotheliosis viral oncogene h...
    59(a)
    1 ↔ 1
    LGf(3447292-3458483)
    African clawed frog
    (Xenopus laevis)
    Amphibia relb-A2 v-rel reticuloendotheliosis viral oncogene homolog more 76.96(n)    D63332.1 
    zebrafish
    (Danio rerio)
    Actinopterygii relb6
    v-rel reticuloendotheliosis viral oncogene homolog...
    36(a)
    1 ↔ 1
    15(16119427-16144236) ENSDARG00000086173
    fruit fly
    (Drosophila melanogaster)
    Insecta dl3 immune response transcription factor 45(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for RELB (if available)
    TreeFam Gene Tree for RELB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RELB gene
    NFKB12  REL2  NFKB22  RELA2  
    3 SIMAP similar genes for RELB using alignment to 4 protein entries:     RELB_HUMAN (see all proteins):
    RELA    REL    NFKB2

    RELB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RELB (see all 878)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932965471,2
    --45502748(+) GCGCAG/TTGGCT 1 -- us2k10--------
    rs1839311961,2
    --45502806(+) TTGAAA/CCCGGG 1 -- us2k10--------
    rs72516551,2
    C,F,A,H--45502808(+) gaaccC/Tgggag 1 -- us2k12Minor allele frequency- T:0.50NA 6
    rs1401627121,2
    --45503059(+) GACACC/TCTGCC 1 -- us2k10--------
    rs1453853991,2
    C--45503198(+) GGTTTC/TAGTTT 1 -- us2k10--------
    rs735602251,2
    C,F--45503266(+) ATTCAA/GCTTAC 1 -- us2k13Minor allele frequency- G:0.17WA CSA 122
    rs116674661,2
    C,H--45503343(+) tcatcA/Tcagct 1 -- us2k15Minor allele frequency- T:0.00NS EA NA 424
    rs1864592741,2
    --45503344(+) CATCAC/GAGCTC 1 -- us2k10--------
    rs1913555471,2
    --45503382(+) GCAATC/TCTCCT 1 -- us2k10--------
    rs344151221,2
    C,F--45503513(+) TGGCAT/-CCAAC 1 -- us2k12Minor allele frequency- -:0.05NS 94

    HapMap Linkage Disequilibrium report for RELB (45504688 - 45541456 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RELB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912141CNV Loss21882294
    nsv912134CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RELB
    DNA2.0 Custom Variant and Variant Library Synthesis for RELB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604758    OMIM disorders: --

    Selected diseases for RELB (see all 34):    
    About MalaCards
    severe acute respiratory syndrome    neurologic diseases    pancreatic ductal adenocarcinoma    hodgkin's lymphoma
    hiv-1    kaposi's sarcoma    multiple myeloma    atopic dermatitis
    nasopharyngitis    peritonitis    dermatitis    non-hodgkin lymphoma
    prostate cancer    myeloma    astrocytoma    pancreatitis
    chronic lymphocytic leukemia    sarcoma    prostatitis    influenza


    RELB for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for RELB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 23.8 2 10227387 (1), 19549902 (1)
    breast cancer 17.7 6 9681829 (1), 12897145 (1), 18955032 (1)
    prostate cancer 11.4 11 16261162 (6), 19351823 (4)
    inflammation 7.25 10 9250151 (3), 19690169 (1), 18955032 (1)
    tumors 5.77 9 19351823 (3), 10227387 (1), 12897145 (1), 19549902 (1) (see all 5)
    cancer 0 2 19903458 (1), 16205698 (1)

    Genetic Association Database (GAD): RELB
    Human Genome Epidemiology (HuGE) Navigator: RELB (10 documents)

    Export disorders for RELB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RELB gene, integrated from 10 sources (see all 216):
    (articles sorted by number of sources associating them with RELB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif. (PubMed id 8441398)1, 2, 9 Dobrzanski P.... Bravo R. (Mol. Cell. Biol. 1993)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. (PubMed id 20448286)1, 4 Potter C....Isaacs J.D. (Ann. Rheum. Dis. 2010)
    4. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PubMed id 20873783)1, 2 Vaz Meirelles G.... Kobarg J. (J. Proteome Res. 2010)
    5. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    6. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    7. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    8. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 4 Dieguez-Gonzalez R....Gonzalez A. (Ann. Rheum. Dis. 2009)
    9. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    10. Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules. (PubMed id 18466468)1, 4 Liu-Mares W....Goode E.L. (BMC Proc 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5971 HGNC: 9956 AceView: RELB Ensembl:ENSG00000104856 euGenes: HUgn5971
    ECgene: RELB Kegg: 5971 H-InvDB: RELB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RELB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RELB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RELB gene:
    Search GeneIP for patents involving RELB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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