RELB Gene
protein-coding GIFtS: 62
GCID: GC19P045504
|
|
v-rel reticuloendotheliosis viral oncogene homolog B(Previous name: v-rel avian reticuloendotheliosis viral oncogene homolog...)
| |
Aliases
for RELB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| V-Rel Reticuloendotheliosis Viral Oncogene Homolog B1 2 | | I-REL2 | | REL-B1 2 | | Transcription Factor RelB2 | | V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B (Nuclear Factor OfKappa Light Polypeptide Gene Enhancer In B-Cells 3)1 2 | | V-Rel Reticuloendotheliosis Viral Oncogene Homolog B, Nuclear Factor Of KappaLight Polypeptide Gene Enhancer In B-Cells 32 | | IREL2 5 | | I-Rel3 |
Export aliases for RELB gene to outside databasesPrevious GC identifers: GC19P046149 GC19P045895 GC19P050180 GC19P050196 GC19P041935 |
Summaries
for RELB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RELB_HUMAN, Q01201Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved inmany biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis.NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB,NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and theindividual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishableaffinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalizationas well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in aninactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activationpathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequentlydegraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimericRelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 orREL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway,may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation orgemcitabine treatment
Gene Wiki entry for RELB
|
Genomic Views
for RELB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RELB gene promoter:
GR AP-1 GR-beta ATF-2 STAT3 GR-alpha c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for RELB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RELB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32RELB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P045504: view genomic region
(about GC identifiers)
Start:
|
45,504,688 bp from pter |
End:
|
45,541,452 bp from pter |
Size:
|
36,765 bases |
Orientation:
|
plus strand |
|
Proteins
for RELB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RELB_HUMAN, Q01201 (See
protein sequence)Recommended Name: Transcription factor RelB Size: 579 amino acids; 62134 Da
Subunit: Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex. Self-associates;the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52.Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID (By similarity)
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Co-localizes with NEK6 in the centrosome
Caution: Was originally (PubMed:1577270) thought to inhibit the transcriptional activity of nuclear factor NF-kappa-B
Secondary accessions: Q6GTX7 Q9UEI7Explore the universe of human proteins at neXtProt for RELB: NX_Q01201
Post-translational modifications:
Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q01201
RELB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006500.2
ENSEMBL proteins: ENSP00000221452 ENSP00000427348 ENSP00000423287 ENSP00000468460 ENSP00000445542
Human Recombinant Protein Products for RELB:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RELB for ontologies About GeneDecksing
RELB Antibody Products:
Assay Products for RELB: |
Protein
Domains /
Families
for RELB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RELB for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q01201ProtoNet protein and cluster: Q01201 3 Blocks protein families: IPB000451 NF-kappa-B/Rel/dorsal family IPB002909 Cell surface receptor IPT/TIG IPB011539 Rel homology
UniProtKB/Swiss-Prot: RELB_HUMAN, Q01201Domain: Both N- and C-terminal domains are required for transcriptional activationSimilarity: Contains 1 RHD (Rel-like) domain |
Function
for RELB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RELB_HUMAN, Q01201Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved inmany biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis.NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB,NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and theindividual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishableaffinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalizationas well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in aninactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activationpathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequentlydegraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimericRelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 orREL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway,may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation orgemcitabine treatmentInduction: Up-regulated by mitogens and NUPR1 Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RELB for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for RELB:
15/17 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Relb) (see all 17):
RELB for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Relbtm1Brv for RELB
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RELB (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RELB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RELB (NM_006509) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RELB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELB |
|
Pathways & Interactions
for RELB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/45 super-pathways (see all 45) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_A3 receptor signaling | | | 2 | Mucin expression in CF via IL-6, IL-17 signaling pathways | | | 3 | Development_PDGF signaling via STATs and NF-kB | | | 4 | Development_A2B receptor- action via G-protein alpha s | | | 5 | Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/40 EMD Millipore Pathways for RELB (see all 40)
3  R&D Systems Pathways for RELB
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RELB
1 
Cell Signaling Technology (CST) Pathway for RELB
5/47  GeneGo (Thomson Reuters) Pathways for RELB (see all 47)
5/6  BioSystems Pathways for RELB (see all 6)
1  PharmGKB Pathway for RELB
2 
Kegg Pathways (Kegg details for RELB):
RELB for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RELB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/121 Interacting proteins for RELB (Q012011, 2, 3 ENSP000002214524) via UniProtKB, MINT, STRING, and/or I2D (see all 121)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0010628 | positive regulation of gene expression |
IEA | -- | | GO:0019882 | antigen processing and presentation |
IEA | -- | | GO:0042088 | T-helper 1 type immune response |
-- | -- |
RELB for ontologies About GeneDecksing
|
Drugs & Compounds
for RELB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RELB
Search CenterWatch for drugs/clinical trials and news about RELB
|
Transcripts
for RELB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RELB gene: NM_006509.3 Unigene Cluster for RELB: V-rel reticuloendotheliosis viral oncogene homolog B Hs.654402 [show with all ESTs]Unigene Representative Sequence: M832217 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000221452(uc021uvp.1 uc021uvq.1) ENST00000509480 ENST00000505236
ENST00000510184 ENST00000509229 ENST00000589972 ENST00000540120
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RELB (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RELB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RELB (NM_006509) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RELB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELB |
Additional cDNA sequence: AK290594.1 BC028013.1 M83221.1 5 DOTS entries: DT.100752175 DT.100860854 DT.100690152 DT.95161974 DT.75196529 24/87 AceView cDNA sequences (see all 87): BI908595 BU179562 BQ924660 AI738667 AI393279 AI676030 BC028013 BE397094 BM930071 NM_006509 CR607370 AJ714299 BM550511 AW206241 AI923086 AI831842 BP339329 BM763946 BM684710 BM723531 BX372372 BU558148 M83221 CB529212
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RELB About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | |
ECgene alternative splicing isoforms for RELB
|
Expression
for RELB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RELB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGGGCACC
About this image
See RELB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RELB
SOURCE GeneReport for Unigene cluster: Hs.654402
SABiosciences Expression via Pathway-Focused PCR Arrays including RELB (see all 7): | NFKB Signaling Targets in human mouse rat | | Antigen Presenting Cells in human mouse rat | | NFKB Signaling Pathway in human mouse rat | | Transcription Factors in human mouse rat | | T Helper Cell Differentiation in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RELB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RELB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RELB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RELB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELB |
Orthologs
for RELB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RELB gene from 6/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Relb1 , 5 |
avian reticuloendotheliosis viral (v-rel) oncogene more1, 5 |
84.59(n)1
89.93(a)1 |
|
7 (9.93 cM)5
196981 NM_009046.21 NP_033072.21
196062175 |
chicken
(Gallus gallus) |
Aves |
RELB1 |
v-rel reticuloendotheliosis viral oncogene homolog more |
65.63(n)
64.52(a) |
|
395656 NM_204850.1 NP_990181.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RELB6 |
-- |
56(a) |
1 ↔ 1 |
LGf(3447292-3458483) |
African clawed frog
(Xenopus laevis) |
Amphibia |
relb-A2 |
v-rel reticuloendotheliosis viral oncogene homolog more |
76.96(n) |
|
D63332.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
relb6 |
v-rel reticuloendotheliosis viral oncogene homolog... |
38(a) |
1 ↔ 1 |
15(16119749-16144236) |
fruit fly
(Drosophila melanogaster) |
Insecta |
dl3 |
immune response transcription factor |
45(a)
(best of 2) |
|
-- |
ENSEMBL Gene Tree for RELB (if available)
TreeFam Gene Tree for RELB (if available) |
Paralogs
for RELB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RELB gene
- NFKB12 REL2 NFKB22 RELA2
3 SIMAP similar genes for RELB using alignment to 4 protein entries: RELB_HUMAN (see all proteins):RELA REL NFKB2
RELB for paralogs About GeneDecksing
|
Genomic Variants
for RELB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RELB (45504688 - 45541452 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RELB: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RELB |
|
Disorders
/ Diseases
for RELB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RELB for disorders About GeneDecksing
OMIM gene information: 604758
OMIM disorders: --
20/34  diseases for RELB (see all 34): About MalaCardsnon-hodgkin lymphoma severe acute respiratory syndrome hodgkin's lymphoma atopic dermatitis
chronic lymphocytic leukemia lymphocytic leukemia kaposi's sarcoma inflammatory breast cancer
multiple myeloma breast cancer rheumatoid arthritis dermatitis
neurologic diseases prostate cancer myeloma sarcoma
hepatocellular carcinoma arthritis ovarian cancer nasopharyngitis
6 Novoseek disease relationships for RELB gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
23.8 |
2 |
10227387 (1), 19549902 (1) |
| breast cancer |
17.7 |
6 |
9681829 (1), 12897145 (1), 18955032 (1) |
| prostate cancer |
11.4 |
11 |
16261162 (6), 19351823 (4) |
| inflammation |
7.25 |
10 |
9250151 (3), 19690169 (1), 18955032 (1) |
| tumors |
5.77 |
9 |
19351823 (3), 10227387 (1), 12897145 (1), 19549902 (1) (see all 5) |
| cancer |
0 |
2 |
19903458 (1), 16205698 (1) |
Human Genome Epidemiology (HuGE) Navigator: RELB (10 documents)
Export disorders for RELB gene to outside databases
|
Publications
for RELB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RELB gene, integrated from 9 sources (see all 209):
(articles sorted by number of sources associating them with RELB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif. (PubMed id 8441398)1, 2, 9 Dobrzanski P.... Bravo R. (1993)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. (PubMed id 1577270)1, 2 Ruben S.M....Rosen C.A. (1992)
- A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site. (PubMed id 1531086)1, 3 Bours V.... Siebenlist U. (1992)
- RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke. (PubMed id 18688039)1, 9 Yang S.R....Rahman I. (2009)
- RelB cellular regulation and transcriptional activity are regulated by p100. (PubMed id 11687592)1, 9 Solan N.J....Paya C.V. (2002)
- RelB regulates human dendritic cell subset development by promoting monocyte intermediates. (PubMed id 15315978)1, 9 Platzer B....Strobl H. (2004)
- RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity. (PubMed id 19351823)1, 9 Xu Y....St Clair W.H. (2009)
- The NF-kappaB factor RelB and histone H3 lysine methy ltransferase G9a directly interact to generate epigenetic silencing in endotoxi n tolerance. (PubMed id 19690169)1, 9 Chen X....McCall C.E. (2009)
- p52-Independent nuclear translocation of RelB promote s LPS-induced attachment. (PubMed id 19903458)1, 9 Saito T....Longo D.L. (2010)
|
External Searches for RELB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RELB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing RELB gene
(According to HUGE)
About This Section
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Specialized Databases showing RELB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for RELB gene:
Search GeneIP for patents involving RELB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RELB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for RELB | | OriGene shRNA RFP for RELB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RELB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RELB | | | OriGene Protein Over-expression Lysate for RELB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RELB | | OriGene 3'-UTR Clone for RELB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RELB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RELB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RELB | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RELB | | OriGene Custom Protein Services for RELB | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RELB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RELB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RELB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RELB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RELB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RELB |
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| | Antibodies & Assays for RELB |
| | | | Search Tocris compounds for RELB |
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 | | | RELB Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELB |
|  |  |  |  | | | | ThermoFisher Antibodies for RELB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELB |
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