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Aliases for RELB Gene

Aliases for RELB Gene

  • V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B 2 3
  • V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B (Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3) 2 3
  • I-REL 3 4
  • IREL 3 6
  • V-Rel Reticuloendotheliosis Viral Oncogene Homolog B, Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3 3
  • Transcription Factor RelB 3
  • REL-B 3

External Ids for RELB Gene

Previous GeneCards Identifiers for RELB Gene

  • GC19P046149
  • GC19P045895
  • GC19P050180
  • GC19P050196
  • GC19P045504
  • GC19P041935

Summaries for RELB Gene

GeneCards Summary for RELB Gene

RELB (V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B) is a Protein Coding gene. Diseases associated with RELB include hiv-1 and prostate cancer. Among its related pathways are MAPK signaling pathway and NF-KappaB Family Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is NFKB1.

UniProtKB/Swiss-Prot for RELB Gene

  • NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52.

Gene Wiki entry for RELB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RELB Gene

Genomics for RELB Gene

Regulatory Elements for RELB Gene

Genomic Location for RELB Gene

Start:
45,001,430 bp from pter
End:
45,038,198 bp from pter
Size:
36,769 bases
Orientation:
Plus strand

Genomic View for RELB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RELB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RELB Gene

Proteins for RELB Gene

  • Protein details for RELB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01201-RELB_HUMAN
    Recommended name:
    Transcription factor RelB
    Protein Accession:
    Q01201
    Secondary Accessions:
    • Q6GTX7
    • Q9UEI7

    Protein attributes for RELB Gene

    Size:
    579 amino acids
    Molecular mass:
    62134 Da
    Quaternary structure:
    • Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex. Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID. Interacts with ARNTL/BMAL1 and the interaction is enhanced in the presence of CLOCK (By similarity).

neXtProt entry for RELB Gene

Proteomics data for RELB Gene at MOPED

Post-translational modifications for RELB Gene

  • Phosphorylation at Thr-103 and Ser-573 is followed by proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RELB Gene

No data available for DME Specific Peptides for RELB Gene

Domains for RELB Gene

Graphical View of Domain Structure for InterPro Entry

Q01201

UniProtKB/Swiss-Prot:

RELB_HUMAN :
  • Q01201
Domain:
  • Both N- and C-terminal domains are required for transcriptional activation
  • Contains 1 RHD (Rel-like) domain.
genes like me logo Genes that share domains with RELB: view

No data available for Gene Families for RELB Gene

Function for RELB Gene

Molecular function for RELB Gene

UniProtKB/Swiss-Prot Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52.
UniProtKB/Swiss-Prot Induction: Up-regulated by mitogens and NUPR1.

Gene Ontology (GO) - Molecular Function for RELB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001047 core promoter binding ISS --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IBA --
genes like me logo Genes that share ontologies with RELB: view
genes like me logo Genes that share phenotypes with RELB: view

Animal Models for RELB Gene

MGI Knock Outs for RELB:

miRNA for RELB Gene

miRTarBase miRNAs that target RELB

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RELB Gene

Localization for RELB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RELB Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RELB Gene COMPARTMENTS Subcellular localization image for RELB gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RELB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22065573
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RELB: view

Pathways for RELB Gene

genes like me logo Genes that share pathways with RELB: view

Gene Ontology (GO) - Biological Process for RELB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with RELB: view

Transcripts for RELB Gene

Unigene Clusters for RELB Gene

V-rel reticuloendotheliosis viral oncogene homolog B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RELB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2:
SP3:
SP4: - -

Relevant External Links for RELB Gene

GeneLoc Exon Structure for
RELB
ECgene alternative splicing isoforms for
RELB

Expression for RELB Gene

mRNA expression in normal human tissues for RELB Gene

mRNA differential expression in normal tissues according to GTEx for RELB Gene

This gene is overexpressed in Whole Blood (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RELB Gene

SOURCE GeneReport for Unigene cluster for RELB Gene Hs.654402

genes like me logo Genes that share expressions with RELB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RELB Gene

Orthologs for RELB Gene

This gene was present in the common ancestor of animals.

Orthologs for RELB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RELB 35
  • 99.54 (n)
  • 99.65 (a)
RELB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RELB 35
  • 88.24 (n)
  • 91.52 (a)
RELB 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RELB 35
  • 89.7 (n)
  • 92.86 (a)
RELB 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Relb 35
  • 84.53 (n)
  • 89.75 (a)
Relb 16
Relb 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RELB 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Relb 35
  • 83.27 (n)
  • 89.86 (a)
lizard
(Anolis carolinensis)
Reptilia RELB 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia relb-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia relb 35
  • 59.66 (n)
  • 62.46 (a)
zebrafish
(Danio rerio)
Actinopterygii relb 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dif 36
  • 14 (a)
ManyToMany
dl 36
  • 17 (a)
ManyToMany
dl 37
  • 45 (a)
Dif 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToOne
Species with no ortholog for RELB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RELB Gene

ENSEMBL:
Gene Tree for RELB (if available)
TreeFam:
Gene Tree for RELB (if available)

Paralogs for RELB Gene

Paralogs for RELB Gene

Selected SIMAP similar genes for RELB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RELB: view

Variants for RELB Gene

Sequence variations from dbSNP and Humsavar for RELB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs874743 -- 45,009,978(-) AAGTA(C/T)CTTAG intron-variant
rs874744 -- 45,010,159(-) TGCCC(A/G)GCTAA intron-variant
rs1076986 -- 45,030,783(-) GTCTC(A/G)CTCTA intron-variant
rs1971786 -- 45,024,310(-) gtggc(A/G)ggtgc intron-variant
rs2060251 -- 45,005,766(-) ATTAG(G/T)TGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RELB Gene

Variant ID Type Subtype PubMed ID
nsv912134 CNV Loss 21882294
nsv912141 CNV Loss 21882294

Relevant External Links for RELB Gene

HapMap Linkage Disequilibrium report
RELB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RELB Gene

Disorders for RELB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for RELB Gene including...

Search for RELB Gene in MalaCards »

(6) Novoseek inferred disease relationships for RELB Gene

Disease -log(P) Hits PubMed IDs
necrosis 23.8 2
breast cancer 17.7 3
prostate cancer 11.4 10
inflammation 7.25 5
tumors 5.77 7

Relevant External Links for RELB

Genetic Association Database (GAD)
RELB
Human Genome Epidemiology (HuGE) Navigator
RELB
genes like me logo Genes that share disorders with RELB: view

No data available for UniProtKB/Swiss-Prot for RELB Gene

Publications for RELB Gene

  1. Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif. (PMID: 8441398) Dobrzanski P. … Bravo R. (Mol. Cell. Biol. 1993) 3 4 23
  2. Expression of the RelB transcription factor correlates with the activation of human dendritic cells. (PMID: 10540217) Clark G.J. … Hart D.N. (Immunology 1999) 3 23
  3. RelB cellular regulation and transcriptional activity are regulated by p100. (PMID: 11687592) Solan N.J. … Paya C.V. (J. Biol. Chem. 2002) 3 23
  4. De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor. (PMID: 15265917) Schjerven H. … Johansen F.E. (J. Immunol. 2004) 3 23
  5. RelB regulates human dendritic cell subset development by promoting monocyte intermediates. (PMID: 15315978) Platzer B. … Strobl H. (Blood 2004) 3 23

Products for RELB Gene

Sources for RELB Gene

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