RELA Gene
protein-coding GIFtS: 69
GCID: GC11M065421
|
|
v-rel reticuloendotheliosis viral oncogene homolog A (avian)(Previous name: nuclear factor of kappa light polypeptide gene enhancer...)
(Previous symbol: NFKB3)
| |
Aliases
for RELA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| V-Rel Reticuloendotheliosis Viral Oncogene Homolog A (Avian)1 2 | | Nuclear Factor NF-Kappa-B P65 Subunit2 3 | | NFKB31 2 3 5 | | NF-Kappa-B P65delta32 | | Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 31 2 3 | | Transcription Factor P652 | | P651 | | |
Export aliases for RELA gene to outside databasesPrevious GC identifers: GC11M067936 GC11M067102 GC11M065671 GC11M065196 GC11M065172 GC11M065178 GC11M061748 |
Summaries
for RELA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RELA:
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasmin an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus andactivates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, orRELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcriptvariants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)
UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206Function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of aseries of signal transduction events that are initiated by a vast array of stimuli related to many biologicalprocesses such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is ahomo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105,NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind atkappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for differentkappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act astranscriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms ofpost-translational modification and subcellular compartmentalization as well as by interactions with other cofactorsor corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of theNF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated byI-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the activeNF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes aretranscriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation ofIL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through theinteraction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in theNF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1
Gene Wiki entry for RELA
|
Genomic Views
for RELA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RELA gene promoter:
HEN1 Sp1 AP-1 ATF-2 p300 STAT3 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for RELA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RELA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13RELA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M065421: view genomic region
(about GC identifiers)
Start:
|
65,421,067 bp from pter |
End:
|
65,430,565 bp from pter |
Size:
|
9,499 bases |
Orientation:
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minus strand |
|
Proteins
for RELA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206 (See
protein sequence)Recommended Name: Transcription factor p65 Size: 551 amino acids; 60219 Da
Subunit: Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-c-Rel complex. Homodimer;component of the NF-kappa-B p65-p65 complex. Component of the NF-kappa-B p65-p52 complex. May interact with ETHE1.Binds AES and TLE1. Interacts with TP53BP2. Binds to and is phosphorylated by the activated form of either RPS6KA4 orRPS6KA5. Interacts with ING4 and this interaction may be indirect. Interacts with CARM1, USP48 and UNC5CL. Interactswith IRAK1BP1 (By similarity). Interacts with NFKBID (By similarity). Interacts with NFKBIA. Interacts with GSK3B.Interacts with NFKBIB (By similarity). Interacts with NFKBIE. Interacts with NFKBIZ. Interacts with EHMT1 (via ANKrepeats) (By similarity). Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP andMAP3K14. Interacts with HDAC3; HDAC3 mediates the deacetylation of RELA. Interacts with HDAC1; the interactionrequires non-phosphorylated RELA. Interacts with CBP; the interaction requires phosphorylated RELA. Interacts(phosphorylated at 'Thr-254') with PIN1; the interaction inhibits p65 binding to NFKBIA. Interacts with SOCS1.Interacts with UXT. Interacts with MTDH and PHF11. Interacts with ARRB2. Interacts with human respiratory syncytialvirus (HRSV) protein M2-1. Interacts with NFKBIA (when phosphorylated), the interaction is direct; phosphorylatedNFKBIA is part of a SCF(BTRC)-like complex lacking CUL1. Interacts with RNF25. Interacts (via C-terminus) with DDX1.Interacts with UFL1 and COMMD1. Interacts with BRMS1; this promotes deacetylation of 'Lys-310'. Interacts with NOTCH2(By similarity). Directly interacts with MEN1; this interaction represses NFKB-mediated transactivation. Interactswith AKIP1, which promotes the phosphorylation and nuclear retention of RELA. Interacts (via the RHD) with GFI1; theinteraction, after bacterial lipopolysaccharide (LPS) stimulation, inhibits the transcriptional activity byinterfering with the DNA-binding activity to target gene promoter DNA
Subcellular location: Nucleus. Cytoplasm. Note=Colocalized with DDX1 in the nucleus upon TNF-alpha induction (Bysimilarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).Colocalizes with GFI1 in the nucleus after LPS stimulation
6 PDB 3D structures from  and Proteopedia  for RELA:1NFI (3D)
2LSP (3D)
2O61 (3D)
3GUT (3D)
3QXY (3D)
3RC0 (3D)
Secondary accessions: Q6GTV1 Q6SLK1Alternative splicing: 4 isoforms: Q04206-1 Q04206-2 Q04206-3 Q04206-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RELA: NX_Q04206
Post-translational modifications:
Ubiquitinated, leading to its proteasomal degradation. Degradation is required for termination of NF-kappa-B response1
Monomethylated at Lys-310 by SETD6. Monomethylation at Lys-310 is recognized by the ANK repeats of EHMT1 and promotesthe formation of repressed chromatin at target genes, leading to down-regulation of NF-kappa-B transcription factoractivity. Phosphorylation at Ser-311 disrupts the interaction with EHMT1 without preventing monomethylation at Lys-310and relieves the repression of target genes (By similarity)1
Phosphorylation at Ser-311 disrupts the interaction with EHMT1 and promotes transcription factor activity (Bysimilarity). Phosphorylation on Ser-536 stimulates acetylation on Lys-310 and interaction with CBP; the phosphorylatedand acetylated forms show enhanced transcriptional activity. Phosphorylation at Ser-276 by RPS6KA4 and RPS6KA5promotes its transactivation and transcriptional activities1
Reversibly acetylated; the acetylation seems to be mediated by CBP, the deacetylation by HDAC3 and SIRT2. Acetylationat Lys-122 enhances DNA binding and impairs association with NFKBIA. Acetylation at Lys-310 is required for fulltranscriptional activity in the absence of effects on DNA binding and NFKBIA association. Acetylation can also lowerDNA-binding and results in nuclear export. Interaction with BRMS1 promotes deacetylation of Lys-310. Lys-310 isdeacetylated by SIRT21
S-nitrosylation of Cys-38 inactivates the enzyme activity (By similarity)1
Sulfhydration at Cys-38 mediates the anti-apoptotic activity by promoting the interaction with RPS3 and activating thetranscription factor activity (By similarity)1
Sumoylation by PIAS3 negatively regulates DNA-bound activated NF-kappa-B1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q04206
RELA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001138610.1 NP_001230913.1 NP_001230914.1 NP_068810.3
ENSEMBL proteins: ENSP00000384273 ENSP00000432537 ENSP00000311508 ENSP00000435290 ENSP00000433526 ENSP00000431304 ENSP00000437137 ENSP00000434008 ENSP00000433144 ENSP00000432922 ENSP00000434372 ENSP00000436545 ENSP00000431153 ENSP00000434745 ENSP00000434098 ENSP00000435531 ENSP00000433616 Reactome Protein details: Q04206
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
RELA for ontologies About GeneDecksing
RELA Antibody Products:
Assay Products for RELA: |
Protein
Domains /
Families
for RELA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RELA for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q04206ProtoNet protein and cluster: Q04206 3 Blocks protein families: IPB000451 NF-kappa-B/Rel/dorsal family IPB002909 Cell surface receptor IPT/TIG IPB011539 Rel homology
UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcriptionfactorsSimilarity: Contains 1 RHD (Rel-like) domain |
Function
for RELA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206Function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of aseries of signal transduction events that are initiated by a vast array of stimuli related to many biologicalprocesses such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is ahomo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105,NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind atkappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for differentkappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act astranscriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms ofpost-translational modification and subcellular compartmentalization as well as by interactions with other cofactorsor corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of theNF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated byI-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the activeNF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes aretranscriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation ofIL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through theinteraction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in theNF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1 Genatlas biochemistry entry for RELA:nuclear transcription factor of kappa light chain enhancer in B cells,3 (p65),NF-kappa B/REL family
Inhib. RNA
Products: |  | EMD Millipore RNAi Products for the Analysis of RELA Gene knock-down | |  | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RELA (see all 7)
OriGene shRNA RFP: RELA
OriGene siRNA: RELA
| | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RELA |
Clone
Products: | | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RELA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RELA (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RELA (NM_021975) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RELA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELA |
Gene Ontology (GO): 5/19 molecular function terms (GO ID links to tree view) (see all 19): About this table
RELA for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for RELA:
Animal Models:
Mouse knock-outs for RELA: Relatm1Yuo Relatm1Bal
15/19 MGI mutant phenotypes (inferred from 9 alleles ) (MGI details for Rela) (see all 19):
RELA for phenotypes About GeneDecksing
|
Pathways & Interactions
for RELA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/118 super-pathways (see all 118) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | Development_PDGF signaling via STATs and NF-kB | | | 3 | Development_A3 receptor signaling | | | 4 | Mucin expression in CF via IL-6, IL-17 signaling pathways | | | 5 | RIP-mediated NFkB activation via DAI | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/50 EMD Millipore Pathways for RELA (see all 50)
3  R&D Systems Pathways for RELA
5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RELA (see all 10)
2 
Cell Signaling Technology (CST) Pathways for RELA
2  Tocris Bioscience Pathways for RELA
5/58  GeneGo (Thomson Reuters) Pathways for RELA (see all 58)
5/41  BioSystems Pathways for RELA (see all 41)
5/41 
Reactome Pathways for RELA (see all 41)
2  PharmGKB Pathways for RELA
5/29 
Kegg Pathways (Kegg details for RELA) (see all 29):
RELA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RELA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/486 Interacting proteins for RELA (Q042061, 2, 3 ENSP000003842734) via UniProtKB, MINT, STRING, and/or I2D (see all 486)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SETD7 | Q8WTS62, 3, ENSP000002740314 | MINT-7263887 MINT-7263974 MINT-7263941 MINT-7263834 MINT-7263864 MINT-7263824 MINT-7263924 MINT-7263960 MINT-7263994 MINT-7263847 I2D:
score=2 STRING: ENSP00000274031 | | NFKB2 | Q006532, 3, ENSP000001894444 | MINT-6178467 MINT-47896 MINT-48764 MINT-47925 MINT-48623 MINT-48943 MINT-6178544 MINT-6178520 I2D:
score=8 STRING: ENSP00000189444 | | NFKB1 | P198381, 2, 3, ENSP000002265744 | EBI-73886,EBI-300010 MINT-47911 MINT-6178467 MINT-48923 MINT-47891 MINT-6178544 MINT-48559 MINT-6178520 MINT-48686 I2D:
score=10 STRING: ENSP00000226574 | | CHUK | O151111, 2, 3, ENSP000003594244 | EBI-73886,EBI-81249 MINT-50107 MINT-48896 MINT-48009 I2D:
score=7 STRING: ENSP00000359424 | | HDAC1 | Q135471, 2, 3, ENSP000003626494 | EBI-73886,EBI-301834 MINT-50171 I2D:
score=8 STRING: ENSP00000362649 |
About this table
Gene Ontology (GO): 5/62 biological process terms (GO ID links to tree view) (see all 62): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001889 | liver development |
IEA | -- | | GO:0001942 | hair follicle development |
IEA | -- | | GO:0002224 | toll-like receptor signaling pathway |
TAS | -- | | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
TAS | -- | | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
TAS | -- |
RELA for ontologies About GeneDecksing
|
Drugs & Compounds
for RELA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RELA for compounds About GeneDecksing
Browse Tocris compounds for RELA
9 Novoseek chemical compound relationships for RELA gene About this table
Search CenterWatch for drugs/clinical trials and news about RELA / TF65
|
Transcripts
for RELA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RELA gene (4 alternative transcripts): NM_001145138.1 NM_001243984.1 NM_001243985.1 NM_021975.3 Unigene Cluster for RELA: V-rel reticuloendotheliosis viral oncogene homolog A (avian) Hs.502875 [show with all ESTs]Unigene Representative Sequence: BC11083018/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25): ENST00000406246(uc001off.3 uc001ofh.3 uc001ofg.3 uc021qlq.1 uc010ron.2 uc009yqr.3)
ENST00000525693(uc001ofe.2) ENST00000308639 ENST00000531484 ENST00000526283(uc009yqs.1)
ENST00000532999 ENST00000526257 ENST00000529389 ENST00000525658 ENST00000533546
ENST00000526738 ENST00000527909 ENST00000534558 ENST00000527749 ENST00000529330
ENST00000532879 ENST00000531238 ENST00000527074
Inhib. RNA
Products: | | EMD Millipore RNAi Products for the Analysis of RELA Gene knock-down | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RELA (see all 7)
OriGene shRNA RFP: RELA
OriGene siRNA: RELA
| | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RELA |
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RELA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RELA (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RELA (NM_021975) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RELA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELA |
Additional cDNA sequence: AK303262.1 AK308020.1 AK308478.1 BC011603.1 BC014095.2 BC033522.1 BC069248.1 BC110830.1 L19067.1 M62399.1 U33838.1 U88316.1 24/31 DOTS entries (see all 31): DT.91765826 DT.453518 DT.120691756 DT.100828990 DT.91713615 DT.100828991 DT.100706889 DT.95168121 DT.120691732 DT.95168124 DT.95168119 DT.95168127 DT.91765817 DT.91765829 DT.95168120 DT.120691718 DT.91765812 DT.99942709 DT.102830297 DT.120691721 DT.120691754 DT.120691767 DT.100830769 DT.120691701 24/513 AceView cDNA sequences (see all 513): BC011603 CA310193 R72435 BQ937279 CA391650 CR598825 BM916512 CA389271 BM917161 AA287356 AU143705 BG911494 BU543477 CD672701 M62399 BM054874 BM478772 BM921541 AA236704 AU150783 BE208001 BQ674866 AW604285 BC033522
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for RELA (see all 14) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | |
| SP4: | | | | | - | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 12 |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for RELA
|
Expression
for RELA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RELA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGAAGGAA
About this image
See RELA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RELA
SOURCE GeneReport for Unigene cluster: Hs.502875
SABiosciences Expression via Pathway-Focused PCR Arrays including RELA (see all 13):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RELA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RELA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RELA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RELA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELA |
Orthologs
for RELA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RELA gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RELA1 |
v-rel reticuloendotheliosis viral oncogene homolog more |
63.39(n)
60.32(a) |
|
396027 NM_205129.1 NP_990460.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RELA6 |
-- |
66(a) |
1 ↔ 1 |
AAWZ02040295(2077-6337) |
African clawed frog
(Xenopus laevis) |
Amphibia |
rela-A-prov2 |
v-rel reticuloendotheliosis viral oncogene homolog more |
76.23(n) |
|
BC041188.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rela1 |
v-rel reticuloendotheliosis viral oncogene homolog more |
60.71(n)
59.95(a) |
|
415099 NM_001001839.2 NP_001001839.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
dl1 , 3 |
immune response transcription factor3
dorsal1 |
42(a)
(best of 2)3
55.91(n)1
50.18(a)1 |
|
350471 NM_001169530.11 NP_001163001.11 |
ENSEMBL Gene Tree for RELA (if available)
TreeFam Gene Tree for RELA (if available) |
Paralogs
for RELA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RELA gene
- NFKB12 REL2 NFKB22 RELB2
4 SIMAP similar genes for RELA using alignment to 19 protein entries: TF65_HUMAN (see all proteins):REL RELB NFKB1 NFKB2
RELA for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RELA
PGOHUM00000233546
|
Genomic Variants
for RELA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RELA (65421067 - 65430565 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RELA: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for RELA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RELA for disorders About GeneDecksing
OMIM gene information: 164014
OMIM disorders: --
20/125  diseases for RELA (see all 125): About MalaCardslimb-girdle muscular dystrophy splenic marginal zone lymphoma steroid-resistant nephrotic syndrome diffuse large b-cell lymphoma
human t-cell leukemia virus type 1 non-small cell lung carcinoma lichen planus b-cell lymphomas
oral lichen planus malignant pleural mesothelioma clear cell renal cell carcinoma squamous cell carcinoma
muscular dystrophy ankylosing spondylitis sickle cell anemia adenoid cystic carcinoma
squamous cell carcinoma of the head and neck esophageal squamous cell carcinoma renal cell carcinoma allergic rhinitis
1 disease from the University of Copenhagen DISEASES database for RELA:Cancer 10/17 Novoseek disease relationships for RELA gene (see all 17) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| reticuloendotheliosis |
66.3 |
4 |
16556680 (1), 20332460 (1), 17151784 (1), 17804543 (1) |
| necrosis |
47.1 |
10 |
15876188 (2), 17413040 (1), 12881425 (1), 7852340 (1) (see all 8) |
| tumors |
41.6 |
31 |
16424027 (4), 10467400 (2), 9047386 (2), 17413040 (1) (see all 18) |
| inflammation |
36.4 |
4 |
14691478 (1), 19128834 (1), 19957349 (1), 12509469 (1) |
| colorectal tumors |
28 |
4 |
15112579 (2), 15484295 (2) |
| leukemia t-cell |
23.3 |
1 |
17804543 (1) |
| breast cancer |
16.1 |
5 |
11114727 (2), 12897145 (1), 16408291 (1), 9724088 (1) |
| cancer |
6.37 |
12 |
19345327 (2), 19664134 (2), 20001340 (2), 11591705 (1) (see all 9) |
| carcinoma renal cell |
5.68 |
1 |
10685665 (1) |
| melanoma |
1.51 |
13 |
11775058 (4), 11591705 (3), 8530498 (1) |
Genetic Association Database (GAD): RELA
Human Genome Epidemiology (HuGE) Navigator: RELA (22 documents)
Export disorders for RELA gene to outside databases
|
Publications
for RELA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RELA gene, integrated from 9 sources (see all 968):
(articles sorted by number of sources associating them with RELA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription. (PubMed id 19058135)1, 2, 9 Ishaq M....Guo D. (2009)
- Duration of nuclear NF-kappaB action regulated by reversible acetylation. (PubMed id 11533489)1, 2, 9 Chen L.F.... Greene W.C. (2001)
- A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. (PubMed id 9315679)1, 2, 9 Li Z. and Nabel G.J. (1997)
- Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. (PubMed id 15775976)1, 2, 9 Rocha S.... Perkins N.D. (2005)
- Identification of a ZU5 and death domain-containing inhibitor of NF- kappaB. (PubMed id 14769797)1, 2, 9 Zhang J.... Shu H.-B. (2004)
- NF-kB repression by PIAS3 mediated RelA SUMOylation. (PubMed id 22649547)1, 2 Liu Y....Kulesz-Martin M. (2012)
- AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65. (PubMed id 18178962)1, 2 Gao N....Okamoto T. (2008)
- UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome. (PubMed id 17620405)1, 2 Sun S.... Wang C. (2007)
- Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. (PubMed id 16214042)1, 2 Tzimas C....Hatzivassiliou E.G. (2006)
- IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. (PubMed id 16477006)1, 2 Song Y.J....Cahir-McFarland E. (2006)
|
External Searches for RELA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RELA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RELA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RELA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RELA gene:
Search GeneIP for patents involving RELA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RELA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for RELA | | OriGene shRNA RFP for RELA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RELA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RELA | | | OriGene Protein Over-expression Lysate for RELA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RELA | | OriGene 3'-UTR Clone for RELA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RELA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RELA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RELA | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RELA | | OriGene Custom Protein Services for RELA | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RELA | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RELA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RELA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RELA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RELA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RELA |
| |
 |  |  |  | |
| | Antibodies & Assays for RELA (NFkB-p65) |
| | | | Search Tocris compounds for RELA |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RELA Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELA |
|  |  |  | | | | ThermoFisher Antibody for RELA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELA |
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