Aliases for RELA Gene
Aliases for RELA Gene
External Ids for RELA Gene
- HGNC: 9955
- Entrez Gene: 5970
- Ensembl: ENSG00000173039
- OMIM: 164014
- UniProtKB: Q04206
Previous HGNC Symbols for RELA Gene
- NFKB3
Previous GeneCards Identifiers for RELA Gene
- GC11M067936
- GC11M067102
- GC11M065196
- GC11M065172
- GC11M065178
- GC11M065421
- GC11M061748
Summaries for RELA Gene
-
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for RELA Gene
RELA (RELA Proto-Oncogene, NF-KB Subunit) is a Protein Coding gene. Diseases associated with RELA include Ependymoma and Reticuloendotheliosis. Among its related pathways are Development IGF-1 receptor signaling and Bacterial infections in CF airways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and identical protein binding. An important paralog of this gene is REL.
UniProtKB/Swiss-Prot for RELA Gene
-
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RELA Gene
Genomics for RELA Gene
Regulatory Elements for RELA Gene
Enhancers for RELA Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around RELA on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the RELA gene promoter:
Regulatory Element Products
Genomic Location for RELA Gene
- Chromosome:
- 11
- Start:
- 65,653,596 bp from pter
- End:
- 65,663,094 bp from pter
- Size:
- 9,499 bases
- Orientation:
- Minus strand
Genomic View for RELA Gene
Genes around RELA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
RELA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RELA Gene
Proteins for RELA Gene
-
Protein details for RELA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q04206-TF65_HUMAN
- Recommended name:
- Transcription factor p65
- Protein Accession:
- Q04206
- Q6GTV1
- Q6SLK1
Protein attributes for RELA Gene
- Size:
- 551 amino acids
- Molecular mass:
- 60219 Da
- Quaternary structure:
-
- Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-c-Rel complex. Homodimer; component of the NF-kappa-B p65-p65 complex. Component of the NF-kappa-B p65-p52 complex. May interact with ETHE1. Binds AES and TLE1. Interacts with TP53BP2. Binds to and is phosphorylated by the activated form of either RPS6KA4 or RPS6KA5. Interacts with ING4 and this interaction may be indirect. Interacts with CARM1, USP48 and UNC5CL. Interacts with IRAK1BP1 (By similarity). Interacts with NFKBID (By similarity). Interacts with NFKBIA. Interacts with GSK3B. Interacts with NFKBIB (By similarity). Interacts with NFKBIE. Interacts with NFKBIZ. Interacts with EHMT1 (via ANK repeats) (By similarity). Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HDAC3; HDAC3 mediates the deacetylation of RELA. Interacts with HDAC1; the interaction requires non-phosphorylated RELA. Interacts with CBP; the interaction requires phosphorylated RELA. Interacts (phosphorylated at Thr-254) with PIN1; the interaction inhibits p65 binding to NFKBIA. Interacts with SOCS1. Interacts with UXT. Interacts with MTDH and PHF11. Interacts with ARRB2. Interacts with human respiratory syncytial virus (HRSV) protein M2-1. Interacts with NFKBIA (when phosphorylated), the interaction is direct; phosphorylated NFKBIA is part of a SCF(BTRC)-like complex lacking CUL1. Interacts with RNF25. Interacts (via C-terminus) with DDX1. Interacts with UFL1 and COMMD1. Interacts with BRMS1; this promotes deacetylation of Lys-310. Interacts with NOTCH2 (By similarity). Directly interacts with MEN1; this interaction represses NFKB-mediated transactivation. Interacts with AKIP1, which promotes the phosphorylation and nuclear retention of RELA. Interacts (via the RHD) with GFI1; the interaction, after bacterial lipopolysaccharide (LPS) stimulation, inhibits the transcriptional activity by interfering with the DNA-binding activity to target gene promoter DNA. Interacts (when acetylated at Lys-310) with BRD4; leading to activation of the NF-kappa-B pathway. Interacts with MEFV. Interacts with CLOCK (By similarity). Interacts (via N-terminus) with CPEN1; this interaction induces proteolytic cleavage of p65/RELA subunit and inhibition of NF-kappa-B transcriptional activity (PubMed:18212740). Interacts with FOXP3. Interacts with CDK5RAP3; stimulates the interaction of RELA with HDAC1, HDAC2 and HDAC3 thereby inhibiting NF-kappa-B transcriptional activity (PubMed:17785205).
Three dimensional structures from OCA and Proteopedia for RELA Gene
Protein Expression for RELA Gene
Post-translational modifications for RELA Gene
- Monomethylated at Lys-310 by SETD6. Monomethylation at Lys-310 is recognized by the ANK repeats of EHMT1 and promotes the formation of repressed chromatin at target genes, leading to down-regulation of NF-kappa-B transcription factor activity. Phosphorylation at Ser-311 disrupts the interaction with EHMT1 without preventing monomethylation at Lys-310 and relieves the repression of target genes (By similarity).
- Phosphorylation at Ser-311 disrupts the interaction with EHMT1 and promotes transcription factor activity (By similarity). Phosphorylation on Ser-536 stimulates acetylation on Lys-310 and interaction with CBP; the phosphorylated and acetylated forms show enhanced transcriptional activity. Phosphorylation at Ser-276 by RPS6KA4 and RPS6KA5 promotes its transactivation and transcriptional activities.
- Proteolytically cleaved within a conserved N-terminus region required for base-specific contact with DNA in a CPEN1-mediated manner, and hence inhibits NF-kappa-B transcriptional activity (PubMed:18212740).
- Reversibly acetylated; the acetylation seems to be mediated by CBP, the deacetylation by HDAC3 and SIRT2. Acetylation at Lys-122 enhances DNA binding and impairs association with NFKBIA. Acetylation at Lys-310 is required for full transcriptional activity in the absence of effects on DNA binding and NFKBIA association. Acetylation at Lys-310 promotes interaction with BRD4. Acetylation can also lower DNA-binding and results in nuclear export. Interaction with BRMS1 promotes deacetylation of Lys-310. Lys-310 is deacetylated by SIRT2.
- S-nitrosylation of Cys-38 inactivates the enzyme activity.
- Sulfhydration at Cys-38 mediates the anti-apoptotic activity by promoting the interaction with RPS3 and activating the transcription factor activity.
- Sumoylation by PIAS3 negatively regulates DNA-bound activated NF-kappa-B.
- Ubiquitinated, leading to its proteasomal degradation. Degradation is required for termination of NF-kappa-B response.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RELA Gene
- ENSEMBL proteins:
-
- ENSP00000311508
- ENSP00000431153
- ENSP00000431304
- ENSP00000432537
- ENSP00000432922
- ENSP00000433144
- ENSP00000433526
- ENSP00000433616
- ENSP00000434008
- ENSP00000434098
- ENSP00000434372
- ENSP00000434745
- ENSP00000435290
- ENSP00000435531
- ENSP00000436545
- ENSP00000437137
- ENSP00000479572
- ENSP00000483705
- ENSP00000384273
- REFSEQ proteins:
Antibody Products
- EMD Millipore top RELA Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for RELA
- R&D Systems Antibodies for RELA (RelA/NFkB p65)
- Cell Signaling Technology (CST) Antibodies for RELA (NFkB-p65)
-
Custom Antibody ServicesOriGene Antibodies for RELA
- AM00165PU-N
- AM06378SU-N
- AP01419PU-N
- AP01647PU-N
- AP01648PU-N
- AP01650PU-N
- AP01651PU-N
- TA890002
- TA590272
- TA590271
- TA353982
- TA347814
- TA336998
- TA336861
- TA336860
- TA336457
- TA336436
- TA327876
- TA325807
- TA325806
- TA325805
- TA325804
- TA325803
- TA325802
- TA325801
- TA325800
- TA325799
- TA325798
- TA324772
- TA324695
- TA324680
- TA324641
- TA319553
- TA319207
- TA319206
- TA319204
- TA319203
- TA319202
- TA312411
- TA312410
- TA312409
- TA312408
- TA312407
- TA312406
- TA312405
- TA312404
- TA312403
- TA312402
- TA312401
- TA312400
- SP2092P
- R1486
- AP55947PU-S
- AP55947PU-N
- AP31176PU-N
- AP31175PU-N
- AP26430AF-N
- AP26430AF-L
- AP26421AF-N
- AP26421AF-L
- AP26420AF-N
- AP26420AF-L
- AP23407PU-N
- AP21046PU-N
- AP20958PU-N
- AP20825PU-N
- AP20743PU-N
- AP20704PU-N
- AP20196PU-N
- AP15680PU-S
- AP15680PU-N
- AP15680PU-M
- AP08056PU-S
- AP08056PU-N
- AP08012PU-S
- AP08012PU-N
- AP07826SU-N
- AP07825SU-N
- AP07711PU-N
- AP07432PU-N
- AP06546PU-N
- AP06251PU-N
- AP06250PU-N
- AP06249PU-N
- AP06248PU-N
- AP06247PU-N
- AP05688PU-N
- AP02754PU-S
- AP02754PU-N
- AP02720PU-S
- AP02720PU-N
- AP02557PU-S
- AP02557PU-N
- AP02556PU-S
- AP02556PU-N
- AP02555PU-S
- AP02555PU-N
- AP02554PU-S
- AP02554PU-N
- AP02553PU-S
- AP02553PU-N
- AP02476PU-S
- AP02476PU-N
- AP02312PU-S
- AP02312PU-N
- AP01652PU-N
- Novus Biologicals Antibodies for RELA
-
Cloud-Clone Corp. Antibodies for RELA
- Invitrogen Antibodies for RELA
- antibodies-online Antibodies for RELA: See all 1220
- GeneTex RELA antibody for RELA
-
Custom Antibody ServicesProSci Antibodies for RELA
-
Santa Cruz Biotechnology (SCBT) Antibodies for RELA
- NF B p65 (E-5) X
- NF B p65 (E-5)
- NF B p65 (A-12) X
- NF B p65 (A-12)
- NF B p65 (G-8) X
- NF B p65 (G-8)
- p-NF B p65 (A-8)
- p-NF B p65 (27.Ser 536) X
- p-NF B p65 (27.Ser 536)
- p-NF B p65 (49.Ser 311) X
- p-NF B p65 (49.Ser 311)
- p-NF B p65 (37.Ser 311) X
- p-NF B p65 (37.Ser 311)
- NF B p65 (4H212)
- NF B p65 (4H211)
- NF B p65 (112A1021)
- NF B p65 (F-6) X
- NF B p65 (F-6)
Protein Products
- Enzo Life Sciences proteins for RELA
-
OriGene Purified Proteins for RELA
- Search Origene for MassSpec and Protein Over-expression Lysates for RELA
- Origene Custom Protein Services for RELA
- Sino Biological Recombinant Proteins for RELA
- Browse Sino Biological Cell Lysates
-
Cloud-Clone Corp. Proteins for RELA
- antibodies-online Proteins for RELA: See all 19
- Search antibodies-online for peptides
- Search GeneTex for Proteins for RELA
-
ProSci Proteins for RELA
Assay Products
- EMD Millipore Kits and Assays for RELA
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for RELA (RelA/NFkB p65)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for RELA (NFkB-p65)
- Enzo Life Sciences assays for RELA
-
Cloud-Clone Corp Assay Kits for RELA
- eBioscience NFkB Pathway Activation InstantOne ELISA 96 tests for RELA
- antibodies-online Kits for RELA: See all 94
-
Abcam assays for RELA
No data available for DME Specific Peptides for RELA Gene
Domains & Families for RELA Gene
Gene Families for RELA Gene
Protein Domains for RELA Gene
Suggested Antigen Peptide Sequences for RELA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q04206UniProtKB/Swiss-Prot:
TF65_HUMAN :- the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
- Domain:
-
- the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Function for RELA Gene
Molecular function for RELA Gene
- GENATLAS Biochemistry:
- nuclear transcription factor of kappa light chain enhancer in B cells,3 (p65),NF-kappa B/REL family
- UniProtKB/Swiss-Prot Function:
- NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IMP,IDA | 18045535 |
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IDA | 17350185 |
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IDA | 1406630 |
| GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific | IMP | 26268439 |
| GO:0001046 | core promoter sequence-specific DNA binding | IEA | -- |
Phenotypes for RELA Gene
- MGI mutant phenotypes for RELA:
-
inferred from 10 alleles
- mortality/aging
- cellular phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- integument phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- GenomeRNAi human phenotypes for RELA:
-
- Decreased viability
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased p24 protein expression
- Decreased NF-kappaB reporter expression
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Decreased IL-8 secretion
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased interferon-beta reporter expression
- Upregulation of RLR pathway after Sendai virus (SeV) infection
- Decreased Tat-dependent transcription
- Decreased HIV-1 infection
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Downregulation of NFkappaB pathway
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RELA
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RELA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RELA gene
- Search ViGene Biosciences for RELA
CRISPR Products
-
OriGene CRISPR knockouts for RELA
-
Santa Cruz Biotechnology (SCBT) CRISPR for RELA
- GenScript: Design CRISPR guide RNA sequences for RELA
miRNA for RELA Gene
- miRTarBase miRNAs that target RELA
-
- hsa-mir-373-3p (MIRT002531)
- hsa-mir-124-3p (MIRT002616)
- hsa-mir-7-5p (MIRT025722)
- hsa-mir-96-5p (MIRT027888)
- hsa-mir-324-5p (MIRT043112)
- hsa-mir-30e-5p (MIRT044156)
- hsa-mir-320a (MIRT044799)
- hsa-mir-1236-3p (MIRT383563)
- hsa-mir-1261 (MIRT559974)
- hsa-mir-3161 (MIRT559975)
- hsa-mir-599 (MIRT559976)
- hsa-mir-6077 (MIRT559977)
- hsa-mir-3134 (MIRT559978)
- hsa-mir-8082 (MIRT559979)
- hsa-mir-4534 (MIRT559980)
- hsa-mir-1303 (MIRT642954)
- hsa-mir-6720-5p (MIRT642955)
- hsa-mir-6866-5p (MIRT642956)
- hsa-mir-6512-3p (MIRT642957)
- hsa-mir-877-5p (MIRT642958)
- hsa-mir-6849-3p (MIRT642959)
- hsa-mir-6859-5p (MIRT642960)
- hsa-mir-3916 (MIRT642961)
- hsa-mir-3125 (MIRT642962)
Transcription Factor Targets for RELA Gene
Targeted motifs for RELA Gene
HOMER Transcription Factor Regulatory Elements motif RELA
- Consensus sequence: AGGGGATTTCCC Submotif: canonical Cell Type: GM12787 GEO ID: GSE19485
miRNA Products
- Search ViGene Biosciences for RELA
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for RELA
- Browse OriGene Inhibitory RNA Products For RELA
-
ViGene Biosciences ready-to-package AAV shRNAs for RELA gene
Clone Products
- Sino Biological Human cDNA Clone for RELA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RELA
- VectorBuilder custom plasmid, inducible vectors for RELA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RELA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for RELA
-
ViGene Biosciences adenoviral particle packaged cDNA for RELA gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RELA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RELA gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11996 ) for RELA
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for RELA Gene
Localization for RELA Gene
Subcellular locations from UniProtKB/Swiss-Prot for RELA Gene
- Nucleus. Cytoplasm. Note=Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after LPS stimulation. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA | 26268439 |
| GO:0005634 | nucleus | IEA,IMP | 9425125 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IDA | 12048232 |
| GO:0005730 | NOT nucleolus | IDA | 21343177 |
Pathways & Interactions for RELA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Toll-Like receptor Signaling Pathways | ||
| 3 | Cytosolic sensors of pathogen-associated DNA | ||
| 4 | Immune response IL-23 signaling pathway | ||
| 5 | Toll-like Receptor Signaling Pathway |
.30
|
|
Pathways by source for RELA Gene
7 Sino Biological pathways for RELA Gene
1 GeneTex pathway for RELA Gene
2 Cell Signaling Technology pathways for RELA Gene
50 BioSystems pathways for RELA Gene
61 Reactome pathways for RELA Gene
2 PharmGKB pathways for RELA Gene
57 KEGG pathways for RELA Gene
58 GeneGo (Thomson Reuters) pathways for RELA Gene
11 R&D Systems pathways for RELA Gene
2 Tocris pathways for RELA Gene
10 Qiagen pathways for RELA Gene
Interacting Proteins for RELA Gene
Selected Interacting proteins:
ENSP00000384273
Q04206-TF65_HUMAN
for RELA Gene via
STRING
MINT
UniProtKB
IID
SIGNOR curated interactions for RELA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IDA | 17350185 |
| GO:0001889 | liver development | IEA | -- |
| GO:0001942 | hair follicle development | IEA | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0006117 | acetaldehyde metabolic process | IEA | -- |
Drugs & Compounds for RELA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2- methylphenoxy)acetic acid | Pharma | 0 | ||||
| JSH-23 | Pharma | NF-κB inhibitor | 0 | |||
| Kaempferol | Pharma | Apoptosis inducer;antioxidant;flavonoid, Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter | 0 | |||
| Matrine | Pharma | Alkaloid found in Sophora plant | 0 | |||
| QNZ (EVP4593) | Pharma | Potent NF-κB inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(6) ApexBio Compounds for RELA Gene
| Compound | Action | Cas Number |
|---|---|---|
| 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2- methylphenoxy)acetic acid | 317318-70-0 | |
| JSH-23 | NF-κB inhibitor | 749886-87-1 |
| Kaempferol | Apoptosis inducer;antioxidant;flavonoid | 520-18-3 |
| Matrine | Alkaloid found in Sophora plant | 519-02-8 |
| QNZ (EVP4593) | Potent NF-κB inhibitor | 545380-34-5 |
| Triptolide | IL-2/MMP-3/MMP7/MMP19 inhibitor | 38748-32-2 |
Drug Products
- ApexBio compounds for RELA
Transcripts for RELA Gene
mRNA/cDNA for RELA Gene
- (6) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (513) Selected AceView cDNA sequences:
- (27) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RELA Gene
CRISPR Products
-
OriGene CRISPR knockouts for RELA
-
Santa Cruz Biotechnology (SCBT) CRISPR for RELA
- GenScript: Design CRISPR guide RNA sequences for RELA
miRNA Products
- Search ViGene Biosciences for RELA
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for RELA
- Browse OriGene Inhibitory RNA Products For RELA
-
ViGene Biosciences ready-to-package AAV shRNAs for RELA gene
Clone Products
- Sino Biological Human cDNA Clone for RELA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RELA
- VectorBuilder custom plasmid, inducible vectors for RELA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RELA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11996 ) for RELA
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 12 |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: | |
| SP11: | |
| SP12: | |
| SP13: | |
| SP14: |
Expression for RELA Gene
This gene is overexpressed in Peripheral blood mononuclear cells (15.1) and Nasal epithelium (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RELA Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RELA Gene:
RELASOURCE GeneReport for Unigene cluster for RELA Gene:
Hs.502875Evidence on tissue expression from TISSUES for RELA Gene
- Nervous system(4.8)
- Intestine(4.7)
- Bone(4.2)
- Lung(3.8)
- Skin(3.8)
- Spleen(3.6)
- Blood(3.3)
- Kidney(3.2)
- Liver(2.9)
- Lymph node(2.9)
- Muscle(2.8)
- Bone marrow(2.7)
- Heart(2.6)
Primer Products
-
OriGene qPCR primer pairs for RELA
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RELA Gene
Orthologs for RELA Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RELA 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | RELA 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RELA 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RELA 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rela 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Rela 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RELA 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RELA 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | RELA 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rela 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | rela-A-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rela 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | dl 36 35 |
|
||
| Dif 36 35 |
|
- Species where no ortholog for RELA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for RELA Gene
(4) SIMAP similar genes for RELA Gene using alignment to 19 proteins:
Pseudogenes.org Pseudogenes for RELA Gene
Variants for RELA Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs863223356 | Likely pathogenic | 65,661,693(-) | CTGCA(C/T)CCACA | upstream-variant-2KB, reference, missense | |
| rs1000011154 | -- | 65,656,066(+) | GCCAA(C/T)GAGAA | intron-variant | |
| rs1000142733 | -- | 65,657,034(+) | CAAAC(-/A)AAACA | intron-variant | |
| rs1000398241 | -- | 65,664,406(+) | AGACA(C/T)GGTCT | intron-variant, upstream-variant-2KB | |
| rs1000451969 | -- | 65,664,712(+) | TAATT(A/T)ATTAA | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1969n54 | CNV | loss | 21841781 |
| nsv951018 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.03;
21.16% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for RELA Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RELA Gene
Disorders for RELA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ependymoma |
|
|
| reticuloendotheliosis |
|
|
| dysferlinopathy |
|
|
| multiple personality disorder |
|
|
| retinitis pigmentosa-50 |
|
|
Search RELA in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TF65_HUMAN- Note=A chromosomal aberration involving C11orf95 is found in more than two-thirds of supratentorial ependymomas. Translocation with C11orf95 produces a C11orf95-RELA fusion protein. C11orf95-RELA translocations are potent oncogenes that probably transform neural stem cells by driving an aberrant NF-kappa-B transcription program (PubMed:24553141). {ECO:0000269 PubMed:24553141}.
Relevant External Links for RELA
No data available for Genatlas for RELA Gene
Publications for RELA Gene
- The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription. (PMID: 19058135) Ishaq M. … Guo D. (J. Cell. Biochem. 2009) 3 4 22 64
- LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. (PMID: 17785205) Wang J. … Yarbrough W.G. (Cancer Cell 2007) 3 4 22 64
- Duration of nuclear NF-kappaB action regulated by reversible acetylation. (PMID: 11533489) Chen L.F. … Greene W.C. (Science 2001) 3 4 22 64
- A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. (PMID: 9315679) Li Z. … Nabel G.J. (Mol. Cell. Biol. 1997) 3 4 22 64
- NF-kappaB repression by PIAS3 mediated RelA SUMOylation. (PMID: 22649547) Liu Y. … Kulesz-Martin M. (PLoS ONE 2012) 3 4 64
Products for RELA Gene
- R&D Systems Antibodies for RELA (RelA/NFkB p65)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for RELA (RelA/NFkB p65)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for RELA
- AM00165PU-N
- AM06378SU-N
- AP01419PU-N
- AP01647PU-N
- AP01648PU-N
- AP01650PU-N
- AP01651PU-N
- AP01652PU-N
- AP02312PU-N
- AP02312PU-S
- AP02476PU-N
- AP02476PU-S
- AP02553PU-N
- AP02553PU-S
- AP02554PU-N
- AP02554PU-S
- AP02555PU-N
- AP02555PU-S
- AP02556PU-N
- AP02556PU-S
- AP02557PU-N
- AP02557PU-S
- AP02720PU-N
- AP02720PU-S
- AP02754PU-N
- AP02754PU-S
- AP05688PU-N
- AP06247PU-N
- AP06248PU-N
- AP06249PU-N
- AP06250PU-N
- AP06251PU-N
- AP06546PU-N
- AP07432PU-N
- AP07711PU-N
- AP07825SU-N
- AP07826SU-N
- AP08012PU-N
- AP08012PU-S
- AP08056PU-N
- AP08056PU-S
- AP15680PU-M
- AP15680PU-N
- AP15680PU-S
- AP20196PU-N
- AP20704PU-N
- AP20743PU-N
- AP20825PU-N
- AP20958PU-N
- AP21046PU-N
- AP23407PU-N
- AP26420AF-L
- AP26420AF-N
- AP26421AF-L
- AP26421AF-N
- AP26430AF-L
- AP26430AF-N
- AP31175PU-N
- AP31176PU-N
- AP55947PU-N
- AP55947PU-S
- R1486
- SP2092P
- TA312400
- TA312401
- TA312402
- TA312403
- TA312404
- TA312405
- TA312406
- TA312407
- TA312408
- TA312409
- TA312410
- TA312411
- TA319202
- TA319203
- TA319204
- TA319206
- TA319207
- TA319553
- TA324641
- TA324680
- TA324695
- TA324772
- TA325798
- TA325799
- TA325800
- TA325801
- TA325802
- TA325803
- TA325804
- TA325805
- TA325806
- TA325807
- TA327876
- TA336436
- TA336457
- TA336860
- TA336861
- TA336998
- TA347814
- TA353982
- TA590271
- TA590272
- TA890002
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RELA
- Search Origene for MassSpec and Protein Over-expression Lysates for RELA
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- OriGene qPCR primer pairs for RELA
- OriGene CRISPR knockouts for RELA
- OriGene ORF clones in human for RELA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RELA
- GenScript: Next-day shipping cDNA ORF clone for RELA in any vector
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- GenScript: Design CRISPR guide RNA sequences for RELA
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- Cell Signaling Technology (CST) Antibodies for RELA (NFkB-p65)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for RELA (NFkB-p65)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for RELA
- Sino Biological Recombinant Proteins for RELA
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
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- Sino Biological Transfection Reagents
- Enzo Life Sciences proteins for RELA
- Enzo Life Sciences assays for RELA
- Browse drugs & compounds from Enzo Life Sciences
- Search Enzo Life Sciences for proteins, assays, substrates, inhibitors & antibodies
- Novus Biologicals Antibodies for RELA
- Novus Biologicals proteins and lysates for RELA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for RELA
- Cloud-Clone Corp. Proteins for RELA
- Cloud-Clone Corp Assay Kits for RELA
- Invitrogen Antibodies for RELA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for RELA
- Addgene plasmids for RELA
- Search eBioscience for RELA related proteins
- eBioscience NFkB Pathway Activation InstantOne ELISA 96 tests for RELA
- eBioscience FlowRNA Probe Sets (VA1-11996 ) for RELA
- antibodies-online Antibodies for RELA: See all 1220
- antibodies-online Kits for RELA: See all 94
- antibodies-online Proteins for RELA: See all 19
- Search antibodies-online for peptides
- GeneTex RELA antibody for RELA
- Search GeneTex for Proteins for RELA
- ViGene Biosciences adenoviral particle packaged cDNA for RELA gene
- ViGene Biosciences lentiviral particle packaged cDNA for RELA gene
- ViGene Biosciences ready-to-package AAV shRNAs for RELA gene
- Search ViGene Biosciences for RELA
- Santa Cruz Biotechnology (SCBT) Antibodies for RELA
- NF B p65 (F-6)
- NF B p65 (F-6) X
- NF B p65 (112A1021)
- NF B p65 (4H211)
- NF B p65 (4H212)
- p-NF B p65 (37.Ser 311)
- p-NF B p65 (37.Ser 311) X
- p-NF B p65 (49.Ser 311)
- p-NF B p65 (49.Ser 311) X
- p-NF B p65 (27.Ser 536)
- p-NF B p65 (27.Ser 536) X
- p-NF B p65 (A-8)
- NF B p65 (G-8)
- NF B p65 (G-8) X
- NF B p65 (A-12)
- NF B p65 (A-12) X
- NF B p65 (E-5)
- NF B p65 (E-5) X
- Search Santa Cruz Biotechnology (SCBT) for RELA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RELA
- Custom Antibody ServicesProSci Antibodies for RELA
- ProSci Proteins for RELA
- Horizon Cell Lines for RELA
- Cyagen custom Knockout/knockin (KOKI) mouse models for RELA
- VectorBuilder custom plasmid, inducible vectors for RELA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RELA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for RELA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
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- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (50) eBioscience
- (51) Atlas
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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