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RELA Gene

protein-coding   GIFtS: 72

GC11M065178
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
(Previous name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NFKB3)
Services    

Aliases &
Descriptions
for RELA

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
MGC131774 2
NFKB3 2, 3, 5
p65 1, 2
Descriptions
Nuclear factor NF-kappa-B p65 subunit 3
nuclear factor of kappa light polypeptide gene enhancer in
B-cells 3 1, 2
v-rel avian reticuloendotheliosis viral oncogene homolog A
(nuclear factor of kappa light polypeptide gene enhancer
in B-cells 3 (p65)) 2
v-rel reticuloendotheliosis viral oncogene homolog A 2
v-rel reticuloendotheliosis viral oncogene homolog A
(avian) 2
v-rel reticuloendotheliosis viral oncogene homolog A,
nuclear factor of kappa light polypeptide gene enhancer in
B-cells 3, p65 2
External Ids
HGNC: 99551
Entrez Gene: 59702
UniProtKB: Q042063
Ensembl: ENSG000001730397
Search outside databases for aliases for RELA gene

Previous GC identifers: GC11M067936 GC11M067102 GC11M065671 GC11M065196 GC11M065172

Summaries
for RELA

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for RELA:
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758)
to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of
NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM
604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues
on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for
destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex.
Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such
as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G
purine; and Y is a C or T pyrimidine).[supplied by OMIM]

UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206
Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell
types and is involved in many biological processed such as inflammation, immunity,
differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric
complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The
dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have
distinct preferences for different kappa-B sites that they can bind with distinguishable affinity
and specificity. Different dimer combinations act as transcriptional activators or repressors,
respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification
and subcellular compartmentalization as well as by interactions with other cofactors or
corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with
members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway,
I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators,
subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the
nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators.
The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8
expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily
through the interaction with p65. p65 shows a weak DNA-binding site which could contribute
directly to DNA binding in the NF-kappa-B complex

Gene Wiki entry for RELA

Genomic Location
for RELA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RELA gene  

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

RELA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M065178:     (about GC identifiers)

Start:
 65,177,649 bp from pter
End:
 65,186,959 bp from pter
Size:
 9,311 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000011.8  NT_033903.7  

Proteins
for RELA

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206 (See protein sequence)
Recommended Name: Transcription factor p65  
Size: 551 amino acids; 60219 Da
Subunit: Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-c-Rel
complex. Homodimer; component of the NF-kappa-B p65-p65 complex. Component of the NF-kappa-B
p65-p52 complex. May interact with ETHE1. Binds AES and TLE1. Interacts with TP53BP2. Binds to and
is phosphorylated by the activated form of either RPS6KA4 or RPS6KA5. Interacts with ING4 and this
interaction may be indirect. Interacts with CARM1, USP48 and UNC5CL. Interacts with IRAK1BP1 (By
similarity).Interacts with NFKBID (By similarity). Interacts with NFKBIA. Interacts with GSK3B.
Interacts with NFKBIB (By similarity). Interacts with NFKBIE. Interacts with NFKBIZ (By
similarity). Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP
and MAP3K14. Interacts with HDAC3; HDAC3 mediates the deacetylation of RELA. Interacts with HDAC1;
the interaction requires non-phosphorylated RELA. Interacts with CBP; the interaction requires
phosphorylated RELA. Interacts (phosphorylated at 'Thr-254') with PIN1; the interaction inhibits
p65 binding to NFKBIA. Interacts with SOCS1. Interacts with UXT. Interacts with MTDH. Interacts
with human respiratory syncytial virus (HRSV) protein M2-1
Subcellular location: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an
inactive form complexed to an inhibitor (I-kappa-B)
PDB structure from and Proteopedia :
1NFI (3D)    2O61 (3D)    
Secondary accessions: Q6GTV1 Q6SLK1
Alternative splicing: 4 isoforms:  Q04206-1   Q04206-2   Q04206-3   Q04206-4   

Post-translational modifications:

  • Ubiquitinated, leading to its proteosomal degradation. Degradation is required for termination of
    NF-kappa-B response1
  • Phosphorylation on 'Ser-536' stimulates acetylation on 'Lys-310' and interaction with CBP; the
    phosphorylated and acetylated forms show enhanced transcriptional activity1
  • Reversibly acetylated; the acetylation seems to be mediated by CBP, the deacetylation by HDAC3.
    Acetylation at 'Lys-122' enhances DNA binding and impairs association with NFKBIA. Acetylation at
    'Lys-310' is required for full transcriptional activity in the absence of effects on DNA binding
    and NFKBIA association. Acetylation can also lower DNA-binding and results in nuclear export1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001138610.1  NP_068810.3  


    ENSEMBL proteins: 
    ENSP00000310229 ENSP00000311508 ENSP00000384273 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for RELA
    Recombinant Proteins from Abcam (NFkB, NFkB p65)
    Human Recombinant Proteins from Abnova (RELA)
                  OriGene Purified Recombinant Human Protein: RELA 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA3140380
    GO:0005654 nucleoplasm EXP10723127
    GO:0005667 transcription factor complex IDA12048232
    GO:0005737 cytoplasm IDA3140380
    GO:0005829 cytosol EXP10723127
    About this table

    Antibodies for RELA: 
    Invitrogen Antibodies for RELA
    Millipore Mono- and Polyclonal Antibodies for the study of RELA
    Sigma-Aldrich Antibodies for RELA
    R&D Systems Antibodies for RELA
    Cell Signaling Technology (CST) Antibodies for RELA  (NF-KappaB p65)
    Antibodies from Abcam (NFkB, NFkB p65), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibodies for RELA

    Assays for RELA: 
    Invitrogen Assays for RELA
    Millipore Kits and Assays for the Analysis of RELA
    Browse R&D Systems for biochemical assays
    Cell Signaling Technology (CST) Sandwich ELISA Kits for RELA (NF-KappaB p65)
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for RELA

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro domains/families:
     IPR002909 IPT_TIG_rcpt
     IPR013783 Ig-like_fold
     IPR000451 NF_Rel_dor
     IPR011539 RHD


       GeneDecks  RELA for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q04206

    ProtoNet protein and cluster: Q04206

    3 Blocks protein families:
    IPB000451 NF-kappa-B/Rel/dorsal family
    IPB002909 Cell surface receptor IPT/TIG
    IPB011539 Rel homology


    UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206
    Similarity: Contains 1 RHD (Rel-like) domain

    Gene Function
    for RELA

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (RELA)
    Millipore RNAi Products for the Analysis of RELA Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (RELA)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001145138

                  Applied Biosystems Silencer® siRNAs for RELA

                  Sigma-Aldrich siRNA for RELA  
                         Sigma-Aldrich shRNA Panels and shRNA for RELA  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RELA
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145138
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145138
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001145138 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_021975

    UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206
    Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell
    types and is involved in many biological processed such as inflammation, immunity,
    differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric
    complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
    REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The
    dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have
    distinct preferences for different kappa-B sites that they can bind with distinguishable affinity
    and specificity. Different dimer combinations act as transcriptional activators or repressors,
    respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification
    and subcellular compartmentalization as well as by interactions with other cofactors or
    corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with
    members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway,
    I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators,
    subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the
    nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators.
    The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8
    expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily
    through the interaction with p65. p65 shows a weak DNA-binding site which could contribute
    directly to DNA binding in the NF-kappa-B complex

    Genatlas biochemistry entry for RELA:
    nuclear transcription factor of kappa light chain enhancer in B cells,3 (p65),NF-kappa B/REL family

    15/20 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Rela) (see all 20 ):

    cellulardigestive/alimentaryembryogenesisendocrine/exocrine gland
    growth/sizehematopoietic systemhomeostasis/metabolismimmune systemlethality-postnatal
    lethality-prenatal/perinatallife span-post-weaning/aginglimbs/digits/tailliver/biliary systemmuscle

    5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003705 RNA polymerase II transcription factor activity, enhancer binding IDA3091258
    GO:0004672 protein kinase activity IEA--
    GO:0019901 protein kinase binding IPI10521409 15465828
    GO:0042301 phosphate binding IDA10521409
    GO:0042802 identical protein binding IDA9437432
    About this table

    Pathways & Interactions
    for RELA

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5/39 Invitrogen iPath™ Online BioAtlas - Pathways for RELA (see all 39 ) (Maps provided by GeneGo):
     IL4 signaling pathway
     A2BR signaling via G-alpha-q: PRKCB/G/Q specific pathways (map 3a)
     Putative SUMO-1 pathway
     PDGF signaling via STATs and NF-kB
     TCR and CD28 co-stimulation in activation of NF-kB

       GeneDecks  RELA for the pathways selected above  
    About GeneDecksing

    5/50 Millipore Pathways for RELA (see all 50 )
     Immune response MIF-mediated glucocorticoid regulation
     Immune response MIF in innate immunity response
     Development TGF-beta receptor signaling
     Immune response IL-1 signaling pathway
     Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

       GeneDecks  RELA for the pathways selected above  
    About GeneDecksing

    5/65 Sigma-Aldrich "Your Favorite Gene" Pathways for  RELA  (Your Favorite Gene powered by Ingenuity) (see all 65 ) 
     4-1BB Signaling in T Lymphocytes
     CD40 Signaling
     Ceramide Signaling
     Role of PKR in Interferon Induction and Antiviral Response
     LXR/RXR Activation

       GeneDecks  RELA for the pathways selected above  
    About GeneDecksing

    1 Cell Signaling Technology (CST) Pathway for RELA: 
     NF-kB Signaling

       GeneDecks  RELA for the pathways selected above  
    About GeneDecksing

    5/13 Kegg Pathways  (Kegg details for RELA) (see all 13 ):
     hsa04010 MAPK signaling pathway
     hsa04210 Apoptosis
     hsa04620 Toll-like receptor signaling pathway
     hsa04660 T cell receptor signaling pathway
     hsa04662 B cell receptor signaling pathway

       GeneDecks  RELA for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  RELA 


    5/435 Interacting proteins for RELA (Q042061, 2 ENSP000003115083) via UniProtKB, MINT, and/or STRING (see all 435 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB2Q006532, ENSP000003370013MINT-6178467 MINT-47896 MINT-48764 MINT-47925 MINT-48623 MINT-48943 MINT-6178544 MINT-6178520 STRING (score=.99)
    NCF1P145982, ENSP000002894733MINT-58638 MINT-58634 MINT-58635 MINT-58636 MINT-58633 MINT-58637 STRING (score=.73)
    UBCP629882, ENSP000003448183MINT-4140700 MINT-48952 MINT-4140715 MINT-4140688 STRING (score=.978)
    BCL3P207492, ENSP000001642273MINT-6178467 MINT-6178520 MINT-6178544 STRING (score=.994)
    PRKACAP176122, ENSP000003095913MINT-50025 MINT-50026 MINT-50065 STRING (score=.894)
    About this table

    5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889 liver development IEA--
    GO:0001942 hair follicle development IEA--
    GO:0006916 anti-apoptosis IDA10747850
    GO:0006954 inflammatory response IDA12924514
    GO:0006968 cellular defense response NAS8717528
    About this table

    Drugs & Compounds
    for RELA

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for RELA
    Sigma-Aldrich Small Molecules for RELA:
    Antagonist

    Compounds for RELA available from Tocris Bioscience
    5 Novoseek chemical compound relationships for RELA gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    deoxycholic acid 24.49 4 14726307 (2), 15876188 (1)
    okadaic acid 9.35 2 11591705 (1)
    lysine 7.31 3 19262565 (3)
    oxygen 0.00 1 16919261 (1)
    calcium 0.00 1 16556680 (1)
    About this table


    Transcripts
    for RELA

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (RELA)
    Millipore RNAi Products for the Analysis of RELA Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (RELA)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001145138

                  Sigma-Aldrich siRNA for RELA  
                         Sigma-Aldrich shRNA Panels and shRNA for RELA  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_021975  

    REFSEQ mRNAs for RELA gene (2 alternative transcripts): 

    NM_001145138.1   NM_021975.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_021975  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145138
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145138
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001145138 

    Additional cDNA sequence: 

    AK303262.1 AK308020.1 AK308478.1 BC011603.1 BC014095.2 BC033522.1 BC069248.1 BC110830.1 
    CR590105.1 CR598825.1 CR605571.1 CR615054.1 L19067.1 M62399.1 U33838.1 U88316.1 

    24/31 DOTS entries (see all 31 ):

    DT.91765826  DT.453518  DT.120691756  DT.100828990  DT.91713615  DT.100828991  DT.100706889  DT.95168124 
    DT.95168121  DT.95168119  DT.95168127  DT.91765829  DT.91765817  DT.95168120  DT.120691718  DT.120691732 
    DT.91765812  DT.99942709  DT.102830297  DT.120691721  DT.120691754  DT.120691767  DT.120691701  DT.120691720 

    24/513 AceView cDNA sequences (see all 513 ):

    CA488197 BM558723 BP431691 CA391650 BU543477 BU857126 BQ647748 AW848518 
    AW612678 BU633061 R72435 CA424867 BP355398 BM054874 CD369183 BI000249 
    M62399 AA236704 BE208001 NM_021975 BE906494 BP338125 BQ945537 BM689971 

    highest scoring ESTs for RELA:

    AA227250 AI241350 AL531207 AL702070 AU099013 AU121812 AU124990 AU125193 AU131718 AU143705 

    Unigene Cluster for RELA:

    V-rel reticuloendotheliosis viral oncogene homolog A (avian)
    Hs.502875  [show with all ESTs]
    Unigene Representative Sequence: BC110830


    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for RELA (see all 14 )

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^
    SP1:                                      -                       -     -                                                                                       
    SP2:              -     -     -           -                       -     -                                                                                       
    SP3:                                      -                       -     -                                         -     -     -     -     -     -               
    SP4:              -                       -                       -     -                                                                                       
    SP5:                                                              -     -                                                                                       

    ExUns: 12
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      

    About this scheme

    ECgene alternative splicing isoforms for RELA

    3 Ensembl transcripts including schematic representations:
    ENST00000308546  ENST00000308639  ENST00000406246  

    Expression
    for RELA

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RELA expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RELA

    1 / 2 / 3

    8 probe-sets matching RELA gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		1045_s_at2, 3 U95-A 1 1.00 1.00 0.80 0.63 U33838 0.80 1.00 0.91 1

    		1295_at2, 3 U95-A 1 1.00 1.00 0.87 1.21 L19067 0.60 1.00 0.82 1

    		1271_g_at2, 3 U95-A 1 1.00 1.00 0.71 1.07 L19067 0.60 1.00 0.82 1

    		36645_at2, 3 U95-A 1 0.94 1.00 0.69 1.10 L19067 0.60 1.00 0.82 1

    		201783_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_021975 0.60 1.00 0.82 1

    		209878_s_at2, 3 U133-A 1 1.00 1.00 -- -- M62399 0.80 1.00 0.91 1

    		201783_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		209878_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCTGAAGGAA

    SOURCE GeneReport for Unigene cluster: Hs.502875

    Expression variation in blood from EXPOLDB for RELA

    Orthologs
    for RELA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for RELA gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 RELA1   -- v-rel reticuloendotheliosis viral oncogene homolog more 90.99(n)
    93.33(a)    		 483729  XM_540850.2  XP_540850.2 
    chimpanzee
    (Pan troglodytes)    		 RELA1   -- v-rel reticuloendotheliosis viral oncogene homolog more 99.76(n)
    99.64(a)    		 466665  XM_001170057.1  XP_001170057.1 
    cow
    (Bos taurus)    		 RELA1   -- v-rel reticuloendotheliosis viral oncogene homolog more 90.64(n)
    92.48(a)    		 508233  XM_584983.3  XP_584983.2 
    rat
    (Rattus norvegicus)    		 Rela1   -- v-rel reticuloendotheliosis viral oncogene homolog more 87.77(n)
    90.69(a)    		 309165  NM_199267.2  NP_954888.1 
    mouse
    (Mus musculus)    		 Rela1, 5 19 (0.50 cM)5
    		 v-rel reticuloendotheliosis viral oncogene homolog more1, 5 86.96(n)1
    89.03(a)1    		 196971  NM_009045.41  NP_033071.11 
     AF1993715  AK0894895  (see all 27)
    About this table        Species with no ortholog for RELA

    ENSEMBL Gene Tree for RELA

    Paralogs
    for RELA

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RELA gene
    NFKB12  REL2  NFKB22  RELB2  

    SNPs/Variants
    for RELA

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/71 NCBI SNPs in RELA are shown (see all 71 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 26)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs127215721,2
    		C,F,H65179923(-) GCATCA/GTGAAG 1 M/V mis16Minor allele frequency- G:0.00EU EA WA 592
    rs71019161,2
    		C,F,H65187936(+) CTCATC/TCCCAA 1 -- ng314Minor allele frequency- T:0.28EU EA WA 418
    --
    rs116063291,2
    		C,H65182840(+) TCGGCA/GGATCT 1 C/R mis1 ese35Minor allele frequency- G:0.00EU EA WA 578
    --
    rs108960281,2
    		A65188763(+) TAATTA/TATTTA 1 -- ng31 tfbs30--------
    rs116073231,2
    		H65187543(+) GGAGCC/TTACAG 1 -- ng314Minor allele frequency- T:0.00EU EA WA 416
    --
    rs115572481,2
    		H65185782(-) CTGCCG/TGGATG 1 R/L mis1 ese34Minor allele frequency- T:0.00EU EA WA 364
    --
    rs127215751,2
    		F65178977(-) GTGTTA/G/TCCTTC 2 F/L mis1 ese31--60
    --
    rs127215741,2
    		C,F65178938(-) GCCCCG/AGCCCC 1 P/P syn1 ese32Minor allele frequency- A:0.02--106
    --
    rs71165711,2
    		C,F65178950(+) aaggcC/Tgaggc 1 S/S syn1 ese34Minor allele frequency- T:0.03NS 192
    rs112272471,2
    		A,C,F,H65179429(-) GTGCCT/GGTGCG 1 -- int117Minor allele frequency- G:0.33NS EU EA WA NA 1692
    About this table

    HapMap Linkage Disequilibrium images for RELA (up to first 250kb)

    Disorders & Mutations
    for RELA

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 164014

    10/17 Novoseek disease relationships for RELA gene (see all 17 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    reticuloendotheliosis 61.94 3 16556680 (1), 17151784 (1), 17804543 (1)
    necrosis 48.13 10 15876188 (2), 17413040 (1), 12881425 (1), 7852340 (1) (see all 8)
    tumors 41.81 31 16424027 (4), 10467400 (2), 9047386 (2), 17413040 (1) (see all 18)
    inflammation 35.67 3 14691478 (1), 19128834 (1), 12509469 (1)
    colorectal tumors 30.64 4 15112579 (2), 15484295 (2)
    leukemia t-cell 25.37 1 17804543 (1)
    breast cancer 14.40 5 11114727 (2), 12897145 (1), 16408291 (1), 9724088 (1)
    carcinoma renal cell 8.81 1 10685665 (1)
    cancer 0.39 7 19345327 (2), 11591705 (1), 16205698 (1), 12527907 (1) (see all 6)
    melanoma 0.00 13 11775058 (4), 11591705 (3), 8530498 (1)
    About this table

    Genetic Association Database: RELA
    Human Genome Epidemiology Navigator: RELA (8 documents)

    Medical News
    for RELA

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for RELA

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/575 PubMed articles for RELA gene (see all 575 ):

    Search for RELA

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RELA

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 5970 HGNC: 9955 AceView: RELA Ensembl:ENSG00000173039 euGenes: HUgn5970
    ECgene: RELA H-InvDB: RELA

    Other Databases showing RELA

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing RELA

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for RELA Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/rela/

    Licensable Technologies
    for RELA

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for RELA

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RELA:
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    		  Free SNP selection tool



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     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Tocris compounds for RELA




     Drugs/Proteins for RELA
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for RELA

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