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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RELA Gene

protein-coding   GIFtS: 71
GCID: GC11M065421

V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog...

(Previous name: nuclear factor of kappa light polypeptide gene enhancer...)
(Previous symbol: NFKB3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A1 2     NF-Kappa-B P65delta32
NFKB31 2 3 5     p652
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 31 2 3     Transcription Factor P652
Nuclear Factor NF-Kappa-B P65 Subunit2 3     V-Rel Reticuloendotheliosis Viral Oncogene Homolog A2

External Ids:    HGNC: 99551   Entrez Gene: 59702   Ensembl: ENSG000001730397   OMIM: 1640145   UniProtKB: Q042063   

Export aliases for RELA gene to outside databases

Previous GC identifers: GC11M067936 GC11M067102 GC11M065671 GC11M065196 GC11M065172 GC11M065178 GC11M061748


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RELA Gene:
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the
cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the
nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either
REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA.
Four transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep
2011)

GeneCards Summary for RELA Gene: 
RELA (v-rel avian reticuloendotheliosis viral oncogene homolog A) is a protein-coding gene. Diseases associated with RELA include septic arthritis, and steroid-resistant nephrotic syndrome, and among its related super-pathways are BCR signaling pathway and Development Prolactin receptor signaling. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFKB1.

UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206
Function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of
a series of signal transduction events that are initiated by a vast array of stimuli related to many biological
processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B
is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105,
NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers
bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for
different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer
combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various
mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions
with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state
complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway,
I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently
degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B
heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex
appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon
NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site
which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the
NF-kappa-B promoter region via association with DDX1

Gene Wiki entry for RELA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RELA gene promoter:
         HEN1   Sp1   AP-1   ATF-2   p300   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RELA promoter sequence
   Search SABiosciences Chromatin IP Primers for RELA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RELA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

RELA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RELA gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M065421:  view genomic region     (about GC identifiers)

Start:
65,421,067 bp from pter      End:
65,430,565 bp from pter
Size:
9,499 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206 (See protein sequence)
Recommended Name: Transcription factor p65  
Size: 551 amino acids; 60219 Da
Subunit: Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-c-Rel complex. Homodimer;
component of the NF-kappa-B p65-p65 complex. Component of the NF-kappa-B p65-p52 complex. May interact with
ETHE1. Binds AES and TLE1. Interacts with TP53BP2. Binds to and is phosphorylated by the activated form of either
RPS6KA4 or RPS6KA5. Interacts with ING4 and this interaction may be indirect. Interacts with CARM1, USP48 and
UNC5CL. Interacts with IRAK1BP1 (By similarity). Interacts with NFKBID (By similarity). Interacts with NFKBIA.
Interacts with GSK3B. Interacts with NFKBIB (By similarity). Interacts with NFKBIE. Interacts with NFKBIZ.
Interacts with EHMT1 (via ANK repeats) (By similarity). Part of a 70-90 kDa complex at least consisting of CHUK,
IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HDAC3; HDAC3 mediates the deacetylation of RELA.
Interacts with HDAC1; the interaction requires non-phosphorylated RELA. Interacts with CBP; the interaction
requires phosphorylated RELA. Interacts (phosphorylated at 'Thr-254') with PIN1; the interaction inhibits p65
binding to NFKBIA. Interacts with SOCS1. Interacts with UXT. Interacts with MTDH and PHF11. Interacts with ARRB2.
Interacts with human respiratory syncytial virus (HRSV) protein M2-1. Interacts with NFKBIA (when
phosphorylated), the interaction is direct; phosphorylated NFKBIA is part of a SCF(BTRC)-like complex lacking
CUL1. Interacts with RNF25. Interacts (via C-terminus) with DDX1. Interacts with UFL1 and COMMD1. Interacts with
BRMS1; this promotes deacetylation of 'Lys-310'. Interacts with NOTCH2 (By similarity). Directly interacts with
MEN1; this interaction represses NFKB-mediated transactivation. Interacts with AKIP1, which promotes the
phosphorylation and nuclear retention of RELA. Interacts (via the RHD) with GFI1; the interaction, after
bacterial lipopolysaccharide (LPS) stimulation, inhibits the transcriptional activity by interfering with the
DNA-binding activity to target gene promoter DNA. Interacts (when acetylated at Lys-310) with BRD4; leading to
activation of the NF-kappa-B pathway
Subcellular location: Nucleus. Cytoplasm. Note=Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By
similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Colocalizes with GFI1 in the nucleus after LPS stimulation
6 PDB 3D structures from and Proteopedia for RELA:
1NFI (3D)        2LSP (3D)        2O61 (3D)        3GUT (3D)        3QXY (3D)        3RC0 (3D)    
Secondary accessions: Q6GTV1 Q6SLK1
Alternative splicing: 4 isoforms:  Q04206-1   Q04206-2   Q04206-3   Q04206-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RELA: NX_Q04206

Explore proteomics data for RELA at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated, leading to its proteasomal degradation. Degradation is required for termination of NF-kappa-B
    response
  • UniProtKB: Monomethylated at Lys-310 by SETD6. Monomethylation at Lys-310 is recognized by the ANK repeats of EHMT1 and
    promotes the formation of repressed chromatin at target genes, leading to down-regulation of NF-kappa-B
    transcription factor activity. Phosphorylation at Ser-311 disrupts the interaction with EHMT1 without preventing
    monomethylation at Lys-310 and relieves the repression of target genes (By similarity)
  • UniProtKB: Phosphorylation at Ser-311 disrupts the interaction with EHMT1 and promotes transcription factor activity (By
    similarity). Phosphorylation on Ser-536 stimulates acetylation on Lys-310 and interaction with CBP; the
    phosphorylated and acetylated forms show enhanced transcriptional activity. Phosphorylation at Ser-276 by RPS6KA4
    and RPS6KA5 promotes its transactivation and transcriptional activities
  • UniProtKB: Reversibly acetylated; the acetylation seems to be mediated by CBP, the deacetylation by HDAC3 and SIRT2.
    Acetylation at Lys-122 enhances DNA binding and impairs association with NFKBIA. Acetylation at Lys-310 is
    required for full transcriptional activity in the absence of effects on DNA binding and NFKBIA association.
    Acetylation at Lys-310 promotes interaction with BRD4. Acetylation can also lower DNA-binding and results in
    nuclear export. Interaction with BRMS1 promotes deacetylation of Lys-310. Lys-310 is deacetylated by SIRT2
  • UniProtKB: S-nitrosylation of Cys-38 inactivates the enzyme activity (By similarity)
  • UniProtKB: Sulfhydration at Cys-38 mediates the anti-apoptotic activity by promoting the interaction with RPS3 and activating
    the transcription factor activity (By similarity)
  • UniProtKB: Sumoylation by PIAS3 negatively regulates DNA-bound activated NF-kappa-B
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q04206

  • RELA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RELA Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001138610.1  NP_001230913.1  NP_001230914.1  NP_068810.3  

    ENSEMBL proteins: 
     ENSP00000384273   ENSP00000432537   ENSP00000435290   ENSP00000311508   ENSP00000433526  
     ENSP00000431304   ENSP00000437137   ENSP00000434008   ENSP00000433144   ENSP00000432922  
     ENSP00000434372   ENSP00000436545   ENSP00000431153   ENSP00000434745   ENSP00000434098  
     ENSP00000435531   ENSP00000433616  
    Reactome Protein details: Q04206
    Human Recombinant Protein Products for RELA: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for RELA
    OriGene Purified Protein for RELA
    OriGene Protein Over-expression Lysate for RELA
    OriGene MassSpec for RELA 
    OriGene Custom Protein Services for RELA
    GenScript Custom Purified and Recombinant Proteins Services for RELA
    Novus Biologicals RELA Proteins
    Novus Biologicals RELA Lysate
    Sino Biological Recombinant Protein for RELA
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RELA 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15790681
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IDA12048232
    GO:0005737cytoplasm IDA15790681
    GO:0005829cytosol TAS--

    RELA for ontologies           About GeneDecksing



    RELA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RELA
    R&D Systems Antibodies for RELA (RelA/NFkB p65)
    Cell Signaling Technology (CST) Antibodies for RELA  (NFkB-p65)
    OriGene Antibodies for RELA
    OriGene Custom Antibody Services for RELA
    GenScript Custom Superior Antibodies Services for RELA
    Novus Biologicals RELA Antibodies
    Abcam antibodies for RELA
    Cloud-Clone Corp. Antibodies for RELA 
    ThermoFisher Antibody for RELA
    LSBio Antibodies in human, mouse, rat for RELA 

    Assay Products for RELA: 
    EMD Millipore Kits and Assays for the Analysis of RELA
    OriGene Custom Assay Services for RELA
    R&D Systems ELISAs for RELA (RelA/NFkB p65)         (see all)
    GenScript Custom Assay Services for RELA
    Cell Signaling Technology (CST) Sandwich ELISA Kits for RELA (NFkB-p65)
    Enzo Life Sciences assays for RELA
    Cloud-Clone Corp. ELISAs for RELA 
    Cloud-Clone Corp. CLIAs for RELA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR014756 Ig_E-set
     IPR008967 p53-like_TF_DNA-bd
     IPR002909 IPT_TIG_rcpt
     IPR013783 Ig-like_fold
     IPR000451 NF_Rel_Dor

    Graphical View of Domain Structure for InterPro Entry Q04206

    ProtoNet protein and cluster: Q04206

    3 Blocks protein domains:
    IPB000451 NF-kappa-B/Rel/dorsal family
    IPB002909 Cell surface receptor IPT/TIG
    IPB011539 Rel homology


    UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206
    Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription
    factors
    Similarity: Contains 1 RHD (Rel-like) domain


    RELA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TF65_HUMAN, Q04206
    Function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of
    a series of signal transduction events that are initiated by a vast array of stimuli related to many biological
    processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B
    is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105,
    NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers
    bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for
    different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer
    combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various
    mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions
    with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state
    complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway,
    I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently
    degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B
    heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex
    appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon
    NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site
    which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the
    NF-kappa-B promoter region via association with DDX1

         Genatlas biochemistry entry for RELA:
    nuclear transcription factor of kappa light chain enhancer in B cells,3 (p65),NF-kappa B/REL family

         Gene Ontology (GO): 5/19 molecular function terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15790681
    GO:0003682chromatin binding IDA19058135
    GO:0003700sequence-specific DNA binding transcription factor activity IDA12048232
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA3091258
    GO:0005515protein binding IPI10498867
         
    RELA for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RELA:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

         15/19 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Rela) (see all 19):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  muscle  nervous system 

    RELA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RELA: Relatm1Yuo Relatm1Bal

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RELA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RELA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RELA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RELA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RELA:
    hsa-mir-373 (MIRT002531), hsa-mir-124 (MIRT002616)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RELA
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate RELA (see all 27):
    hsa-miR-596 hsa-miR-3910 hsa-miR-4311 hsa-miR-302d hsa-miR-520e hsa-miR-302e hsa-miR-759 hsa-miR-520a-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    EMD Millipore RNAi Products for the Analysis of RELA Gene knock-down
    OriGene RNAi products in human, mouse, rat for RELA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RELA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RELA
    Sirion Biotech Customized adenovirus for overexpression of RELA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RELA (see all 11)
    OriGene ORF clones in mouse, rat for RELA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RELA (NM_021975)
    Sino Biological Human cDNA Clone for RELA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RELA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RELA
    Sirion Biotech Customized lentivirus for stable overexpression of RELA 
                         Customized lentivirus expression plasmids for stable overexpression of RELA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RELA
    Search LifeMap BioReagents cell lines for RELA
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RELA About   (see all 132)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1B cell receptor signaling pathway
    B cell receptor signaling pathway0.42
    T cell receptor signaling pathway0.38
    BCR signaling pathway0.42
    TCR Signaling Pathway0.35
    2Development Prolactin receptor signaling
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39
    Prolactin signaling pathway0.33
    3TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    TWEAK Signaling Pathway0.31
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    4Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    5RIP-mediated NFkB activation via ZBP1
    RIP-mediated NFkB activation via ZBP10.85
    Activation of NF-KappaB by PKR0.33
    ZBP1(DAI) mediated induction of type I IFNs0.85
    Cellular Transformation by HTLV10.31
    TRAF6 mediated NF-kB activation0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/50 EMD Millipore Pathways for RELA (see all 50)
        Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    Development TGF-beta receptor signaling
    Immune response IL-1 signaling pathway
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5/6 R&D Systems Pathways for RELA (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RELA (see all 10)
        LT-BetaR Pathway
    NF-KappaB (p50-p65) Pathway
    NTHi-Induced Signaling
    Cellular Transformation by HTLV1
    NF-kappaB Activation by Viruses

    2 Cell Signaling Technology (CST) Pathways for RELA
        Chromatin Regulation / Acetylation
    NF-kappaB Signaling

    2 Tocris Bioscience Pathways for RELA
        Toll-like Receptor Pathway
    NF-kappaB Pathway

    5/58 GeneGo (Thomson Reuters) Pathways for RELA (see all 58)
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Development A2A receptor signaling
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Development EGFR signaling pathway

    5/41 BioSystems Pathways for RELA (see all 41)
        EBV LMP1 signaling
    Apoptosis
    Osteopontin Signaling
    NOD pathway
    Selenium Metabolism and Selenoproteins

    3 Sino Biological Pathways for RELA 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    5/41        Reactome Pathways for RELA (see all 41)
        Toll Like Receptor 2 (TLR2) Cascade
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Toll Like Receptor TLR6:TLR2 Cascade
    FCERI mediated NF-kB activation
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex

    2 PharmGKB Pathways for RELA
        EGFR Inhibitor Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    5/45         Kegg Pathways  (Kegg details for RELA) (see all 45):
        MAPK signaling pathway
    Chemokine signaling pathway
    NF-kappa B signaling pathway
    HIF-1 signaling pathway
    PI3K-Akt signaling pathway


    RELA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RELA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/511 Interacting proteins for RELA (Q042061, 2, 3 ENSP000003842734) via UniProtKB, MINT, STRING, and/or I2D (see all 511)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SETD7Q8WTS62, 3, ENSP000002740314MINT-7263887 MINT-7263974 MINT-7263941 MINT-7263834 MINT-7263864 MINT-7263824 MINT-7263924 MINT-7263960 MINT-7263994 MINT-7263847 I2D: score=2 STRING: ENSP00000274031
    NFKB2Q006532, 3, ENSP000001894444MINT-6178467 MINT-47896 MINT-48764 MINT-47925 MINT-48623 MINT-48943 MINT-6178544 MINT-6178520 I2D: score=8 STRING: ENSP00000189444
    NFKB1P198381, 2, 3, ENSP000002265744EBI-73886,EBI-300010 MINT-47911 MINT-6178467 MINT-48923 MINT-47891 MINT-6178544 MINT-48559 MINT-6178520 MINT-48686 I2D: score=10 STRING: ENSP00000226574
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/67 biological process terms (GO ID links to tree view) (see all 67):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0001942hair follicle development IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    RELA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RELA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RELA (TF65)

    9 Novoseek inferred chemical compound relationships for RELA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deoxycholic acid 22.2 4 14726307 (2), 15876188 (1)
    daunorubicin 10.2 5 16424027 (2), 15053878 (1)
    okadaic acid 7.19 2 11591705 (1)
    lysine 4.5 3 19262565 (3)
    paraffin 1.35 2 15112579 (1), 15484295 (1)
    oxygen 0 2 16919261 (1), 19706715 (1)
    calcium 0 1 16556680 (1)
    testosterone 0 1 8798655 (1)
    serine 0 8 19706715 (3)

    Search CenterWatch for drugs/clinical trials and news about RELA / TF65

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RELA gene (4 alternative transcripts): 
    NM_001145138.1  NM_001243984.1  NM_001243985.1  NM_021975.3  

    Unigene Cluster for RELA:

    V-rel reticuloendotheliosis viral oncogene homolog A (avian)
    Hs.502875  [show with all ESTs]
    Unigene Representative Sequence: BC110830
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000406246(uc001off.3 uc001ofh.3 uc001ofg.3 uc021qlq.1 uc010ron.2 uc009yqr.3)
    ENST00000525693(uc001ofe.2) ENST00000526283(uc009yqs.1) ENST00000308639
    ENST00000531484 ENST00000532999 ENST00000526257 ENST00000529389 ENST00000525658
    ENST00000533546 ENST00000526738 ENST00000527909 ENST00000534558 ENST00000527749
    ENST00000529330 ENST00000532879 ENST00000531238 ENST00000527074
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate RELA (see all 27):
    hsa-miR-596 hsa-miR-3910 hsa-miR-4311 hsa-miR-302d hsa-miR-520e hsa-miR-302e hsa-miR-759 hsa-miR-520a-3p
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    Additional mRNA sequence: 

    AK303262.1 AK308020.1 AK308478.1 BC011603.1 BC014095.2 BC033522.1 BC069248.1 BC110830.1 
    L19067.1 M62399.1 U33838.1 U88316.1 

    24/31 DOTS entries (see all 31):

    DT.91765826  DT.453518  DT.120691756  DT.100828990  DT.91713615  DT.100828991  DT.100706889  DT.95168121 
    DT.120691732  DT.95168124  DT.95168119  DT.95168127  DT.91765817  DT.91765829  DT.95168120  DT.120691718 
    DT.91765812  DT.99942709  DT.102830297  DT.120691721  DT.120691754  DT.120691767  DT.100830769  DT.120691701 

    24/513 AceView cDNA sequences (see all 513):

    BQ962381 BQ437947 AI668775 CD672701 BU535592 BU617515 CF264833 CR590105 
    BM918609 BC011603 BI000249 BF108432 BM460998 BM550525 N77886 BQ647748 
    BQ434547 AA287356 NM_021975 BU633061 BG479117 R72435 AI720849 CK824580 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for RELA (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^
    SP1:                                      -                       -     -                                                                                       
    SP2:              -     -     -           -                       -     -                                                                                       
    SP3:                                      -                       -     -                                         -     -     -     -     -     -               
    SP4:              -                       -                       -     -                                                                                       
    SP5:                                                              -     -                                                                                       

    ExUns: 12
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RELA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RELA expression in normal human tissues (normalized intensities)      RELA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGAAGGAA
    RELA Expression
    About this image


    RELA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/40 selected tissues (see all 40) fully expand
     
     Hair (Integumentary System)    fully expand to see all 7 entries
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Epithelium
             oral mucosa ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             neutrophils   

    See RELA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RELA

    SOURCE GeneReport for Unigene cluster: Hs.502875
        SABiosciences Expression via Pathway-Focused PCR Arrays including RELA (see all 13): 
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RELA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RELA gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rela1 , 5 v-rel reticuloendotheliosis viral oncogene homolog more1, 5 87.02(n)1
    89.21(a)1
      19 (4.34 cM)5
    196971  NM_009045.41  NP_033071.11 
     56374835 
    chicken
    (Gallus gallus)
    Aves RELA1 v-rel reticuloendotheliosis viral oncogene homolog more 63.39(n)
    60.32(a)
      396027  NM_205129.1  NP_990460.1 
    lizard
    (Anolis carolinensis)
    Reptilia RELA6
    Uncharacterized protein
    68(a)
    1 ↔ 1
    AAWZ02040295(347-7100)
    African clawed frog
    (Xenopus laevis)
    Amphibia rela-A-prov2 v-rel reticuloendotheliosis viral oncogene homolog more 76.23(n)    BC041188.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rela1 v-rel reticuloendotheliosis viral oncogene homolog more 60.71(n)
    59.95(a)
      415099  NM_001001839.2  NP_001001839.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta dl1 , 3 immune response transcription factor3
    dorsal1
    42(a)
    (best of 2)3
    55.91(n)1
    50.18(a)1
      350471  NM_001169530.11  NP_001163001.11 


    ENSEMBL Gene Tree for RELA (if available)
    TreeFam Gene Tree for RELA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RELA gene
    NFKB12  REL2  NFKB22  RELB2  
    4 SIMAP similar genes for RELA using alignment to 19 protein entries:     TF65_HUMAN (see all proteins):
    REL    NFKB2    RELB    NFKB1

    RELA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RELA
    PGOHUM00000233546


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/304 SNPs in RELA are shown (see all 304)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1458995201,2
    --65341403(+) CTTTCG/TAACAT 4 -- ds50010--------
    rs108960271,2
    C,F,A,H--65341433(+) GCTGGC/GTAGTC 4 -- ds500119Minor allele frequency- G:0.22NS EA NA WA 1682
    rs1859328701,2
    --65341457(+) CACTCC/TCAGCT 4 -- ds50010--------
    rs1392337631,2
    --65341532(+) CAGCGA/GGCTCT 4 -- ds50010--------
    rs10497281,2
    C,F,A,H--65341790(-) TTGGAC/GTCTTG 4 -- ut31 ese315Minor allele frequency- G:0.02NS EA NA 1272
    rs1506531211,2
    C--65341944(+) TCCTG-/GAGAGAG 4 -- ut310--------
    rs115683041,2
    C,F--65342012(-) ACAGAG/CGTCTC 4 -- ut31 ese35Minor allele frequency- C:0.02NS NA 90
    rs1907958921,2
    --65342346(+) CCAAAA/GAGAGA 4 -- ut310--------
    rs1812567261,2
    --65342378(+) TAAAAA/GAATAA 4 -- ut310--------
    rs1858001901,2
    --65342397(+) TCCCCC/GCTCCA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for RELA (65421067 - 65430565 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for RELA (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897723CNV Loss21882294
    nsv897754CNV Loss21882294
    nsv897748CNV Loss21882294
    dgv1175n71CNV Loss21882294
    dgv1180n71CNV Loss21882294
    nsv897736CNV Loss21882294
    dgv1176n71CNV Loss21882294
    dgv1183n71CNV Loss21882294
    dgv1179n71CNV Loss21882294
    dgv1184n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164014    OMIM disorders: --

    20/123 diseases for RELA (see all 123):    About MalaCards
    septic arthritis    steroid-resistant nephrotic syndrome    splenic marginal zone lymphoma    chorioamnionitis
    oral lichen planus    acute monocytic leukemia    hepatitis e    nephrotic syndrome
    peripheral t-cell lymphoma    follicular thyroid carcinoma    hepatopulmonary syndrome    sickle cell anemia
    adenoid cystic carcinoma    keratoconjunctivitis    limb-girdle muscular dystrophy    lichen planus
    shigellosis    angiosarcoma    malignant pleural mesothelioma    adenoiditis

    1 disease from the University of Copenhagen DISEASES database for RELA:
    Cancer

    RELA for disorders           About GeneDecksing

    10/17 Novoseek inferred disease relationships for RELA gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    reticuloendotheliosis 66.3 4 16556680 (1), 20332460 (1), 17151784 (1), 17804543 (1)
    necrosis 47.1 10 15876188 (2), 17413040 (1), 12881425 (1), 7852340 (1) (see all 8)
    tumors 41.6 31 16424027 (4), 10467400 (2), 9047386 (2), 17413040 (1) (see all 18)
    inflammation 36.4 4 14691478 (1), 19128834 (1), 19957349 (1), 12509469 (1)
    colorectal tumors 28 4 15112579 (2), 15484295 (2)
    leukemia t-cell 23.3 1 17804543 (1)
    breast cancer 16.1 5 11114727 (2), 12897145 (1), 16408291 (1), 9724088 (1)
    cancer 6.37 12 19345327 (2), 19664134 (2), 20001340 (2), 11591705 (1) (see all 9)
    carcinoma renal cell 5.68 1 10685665 (1)
    melanoma 1.51 13 11775058 (4), 11591705 (3), 8530498 (1)

    Genetic Association Database (GAD): RELA
    Human Genome Epidemiology (HuGE) Navigator: RELA (22 documents)

    Export disorders for RELA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RELA gene, integrated from 9 sources (see all 1019):
    (articles sorted by number of sources associating them with RELA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription. (PubMed id 19058135)1, 2, 9 Ishaq M....Guo D. (2009)
    2. Duration of nuclear NF-kappaB action regulated by reversible acetylation. (PubMed id 11533489)1, 2, 9 Chen L.F.... Greene W.C. (2001)
    3. A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. (PubMed id 9315679)1, 2, 9 Li Z. and Nabel G.J. (1997)
    4. Genetic variation in the NF{kappa}B pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 4, 9 Dieguez-Gonzalez R....Gonzalez A. (2008)
    5. Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. (PubMed id 15775976)1, 2, 9 Rocha S.... Perkins N.D. (2005)
    6. Identification of a ZU5 and death domain-containing inhibitor of NF- kappaB. (PubMed id 14769797)1, 2, 9 Zhang J.... Shu H.-B. (2004)
    7. NF-kB repression by PIAS3 mediated RelA SUMOylation. (PubMed id 22649547)1, 2 Liu Y....Kulesz-Martin M. (2012)
    8. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    9. Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65. (PubMed id 20547752)1, 2 Sharif-Askari E....Moroy T. (2010)
    10. Association between anti-tumour necrosis factor treat ment response and genetic variants within the TLR and NF{kappa}B signalling pat hways. (PubMed id 20448286)1, 4 Potter C....Wilson A.G. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5970 HGNC: 9955 AceView: RELA Ensembl:ENSG00000173039 euGenes: HUgn5970
    ECgene: RELA Kegg: 5970 H-InvDB: RELA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RELA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RELA Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/rela/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RELA gene:
    Search GeneIP for patents involving RELA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RELA
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
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     Proteins for RELA
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for RELA
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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