 |
 | Services
| |
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Aliases &
Descriptions
for REL
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| C-Rel 2 | | I-Rel 1 | | c-Rel 1 |
| | | Descriptions |
|---|
| C-Rel protein 3 | | C-Rel proto-oncogene protein 2 | | oncogene REL, avian reticuloendotheliosis 2 | | v-rel avian reticuloendotheliosis viral oncogene homolog 1, 2 | | v-rel reticuloendotheliosis viral oncogene homolog 2 | | v-rel reticuloendotheliosis viral oncogene homolog (avian) 2 |
|
| |
Search outside databases for aliases for REL genePrevious GC identifers: GC02P061237 GC02P061067 GC02P061083 |
Summaries
for REL(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for REL:
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which
also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These
proteins are related through a highly conserved N-terminal region termed the 'Rel
domain,' which is responsible for DNA binding, dimerization, nuclear localization, and
binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed
18037997]).[supplied by OMIM]
UniProtKB/Swiss-Prot: REL_HUMAN, Q04864Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a
pleiotropic transcription factor which is present in almost all cell types and is involved in many
biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis
and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like
domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers
bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct
preferences for different kappa-B sites that they can bind with distinguishable affinity and
specificity. Different dimer combinations act as transcriptional activators or repressors,
respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification
and subcellular compartmentalization as well as by interactions with other cofactors or
corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with
members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway,
I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators,
subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the
nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator |
Genomic Location
for REL
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the REL gene 
Entrez Gene cytogenetic band: 2p13-p12 Ensembl cytogenetic band: 2p16.1 HGNC cytogenetic band: 2p13-p12REL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P061020:
(about GC identifiers)
Start:
|
60,962,256 bp from pter |
End:
|
61,003,682 bp from pter |
Size:
|
41,427 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins
for REL
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: REL_HUMAN, Q04864 (See
protein sequence)Recommended Name: C-Rel proto-oncogene protein Size: 619 amino acids; 68520 Da
Subunit: Component of the NF-kappa-B p65-c-Rel complex. Component of the NF-kappa-B p50-c-Rel
complex. Component of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B
c-Rel-c-Rel complex (By similarity). Interacts with NKIRAS1. Interacts with NFKBIB (By
similarity). Interacts with NFKBIE
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q2PNZ7 Q6LDY0Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002899.1
ENSEMBL proteins: ENSP00000295025 ENSP00000377989
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
About this table
Antibodies for REL:
Assays for REL: | Protein
Domains/
Families
for REL(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q04864
ProtoNet protein and cluster: Q04864 3 Blocks protein families: IPB000451 NF-kappa-B/Rel/dorsal family IPB002909 Cell surface receptor IPT/TIG IPB011539 Rel homology
UniProtKB/Swiss-Prot: REL_HUMAN, Q04864Similarity: Contains 1 RHD (Rel-like) domain | Gene Function
for REL
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002908
 Applied Biosystems Silencer® siRNAs for REL
 Sigma-Aldrich siRNA for REL
Sigma-Aldrich shRNA Panels and shRNA for REL
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002908
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002908
untagged cDNA clones in CMV expression vector (see all 2): NM_002908
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_002908
UniProtKB/Swiss-Prot: REL_HUMAN, Q04864Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a
pleiotropic transcription factor which is present in almost all cell types and is involved in many
biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis
and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like
domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers
bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct
preferences for different kappa-B sites that they can bind with distinguishable affinity and
specificity. Different dimer combinations act as transcriptional activators or repressors,
respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification
and subcellular compartmentalization as well as by interactions with other cofactors or
corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with
members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway,
I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators,
subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the
nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activatorGenatlas biochemistry entry for REL:avian reticuloendotheliosis viral (v-rel) oncogene homolog,involved in lymphomagenesis (diffuse
large B cell lymphoma)15 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Rel):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for REL
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for REL (Your Favorite Gene powered by Ingenuity)
Gene Network CentralTM Interacting Genes and Proteins Network for REL
5/93 Interacting proteins for REL (Q048641, 2 ENSP000002950253) via UniProtKB, MINT, and/or STRING (see all 93
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade |
IEP | 12761501 |
About this table
|
Drugs & Compounds
for REL(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for REL |
 Compounds for REL available from Tocris Bioscience
10/12  Novoseek chemical compound relationships for REL gene (see all 12
)
About this table
|
Transcripts
for REL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002908
Sigma-Aldrich siRNA for REL
Sigma-Aldrich shRNA Panels and shRNA for REL
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_002908 REFSEQ mRNAs for REL gene: NM_002908.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002908
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002908
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002908
untagged cDNA clones in CMV expression vector (see all 2): NM_002908
Additional cDNA sequence: AK303926.1 BC051005.1 BC117191.1 BC143885.1 X75042.1 4 DOTS entries: DT.311516 DT.100009811 DT.95360644 DT.91984554 24/37 AceView cDNA sequences (see all 37
):AI910463 AI917588 BF446716 BX111941 BF115212 AA279919 NM_002908 N56815 BE217899 X75042 BM457679 AW206529 BF445023 AA827904 AA122307 AW206098 CD640399 BG431685 BC051005 AA279536 BU657110 AA741446 AI247359 AI760025
 highest scoring ESTs for REL:X75042 AA122307 AA279536 AA279919 AA827904 AW381823 BE935351 BE935362 BF844707 BG431685 Unigene Cluster for REL: V-rel reticuloendotheliosis viral oncogene homolog (avian) Hs.631886 [show with all ESTs]Unigene Representative Sequence: NM_002908
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000295025
ENST00000394479
|
Expression
for REL
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| REL expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for REL
1 / 2 / 3 4 probe-sets matching REL gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.631886
Expression variation in blood from EXPOLDB for REL |
Orthologs
for REL
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for REL gene from 5/9 species (see all 9
)
About this table Species with no ortholog for REL
ENSEMBL Gene Tree for REL | Paralogs
for REL(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for REL gene
- NFKB12 NFKB22 RELB2 RELA2
|
SNPs/Variants
for REL(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for REL (up to first 250kb)
|
Disorders & Mutations
for REL
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 164910
10/24 Novoseek disease relationships for REL gene (see all 24
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia t-cell |
56.67 |
4 |
7935451 (1), 9247567 (1), 8510222 (1) |
| reticuloendotheliosis |
56.08 |
2 |
1848011 (1), 15870177 (1) |
| lymphoma b-cell |
44.75 |
18 |
17072339 (4), 16027730 (2), 17197926 (2), 15644776 (2) (see all 7) |
| htlv-i infections |
37.95 |
1 |
8627746 (1) |
| response acute phase |
36.92 |
1 |
14530385 (1) |
| necrosis |
34.59 |
5 |
8152812 (1), 9435232 (1), 8621542 (1), 10823840 (1) (see all 5) |
| hodgkin disease |
27.74 |
11 |
15644776 (4), 14755244 (1), 18245482 (1), 15870177 (1) (see all 5) |
| inflammation |
25.19 |
3 |
15110174 (1), 12857966 (1), 19347041 (1) |
| tumors |
21.53 |
19 |
17138822 (3), 12897145 (2), 9435232 (1), 10602468 (1) (see all 16) |
| immunodeficiency |
20.16 |
4 |
1493333 (1), 8394446 (1), 15917220 (1), 1741161 (1) |
About this table
Human Gene Mutation Database: REL
Human Genome Epidemiology Navigator: REL (10 documents)
Tumor Gene Database: REL
|
Medical News
for REL(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for REL (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 100/269 PubMed articles for REL gene (see all 269
):- Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor. (PubMed id 8152812)1, 3, 4 Beg A.A. and Baldwin A.S. (1994)
- Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. (PubMed id 15024091)3, 4 Chen Y.... Ghosh G. (2004)
- A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. (PubMed id 9315679)3, 4 Li Z. and Nabel G.J. (1997)
- A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene. (PubMed id 1740106)3, 4 Hansen S.K....Blasi F. (1992)
- I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. (PubMed id 1577270)2, 3 Ruben S.M....Rosen C.A. (1992)
- A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon. (PubMed id 2666912)3, 4 Brownell E.... Rice N.R. (1989)
- Genetic characterization of human c-rel sequences. (PubMed id 3016517)3, 4 Brownell E.... Rice N.R. (1985)
- Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation. (PubMed id 8621542)1, 3 Meyer C.F....Tan T.H. (1996)
- Deficient translocation of c-Rel is associated with impaired Th1 cytokine production in T cells from atopic dermatitis patients. (PubMed id 15660915)1, 3 Dieckhoff K....Jung T. (2005)
- Unraveling androgen receptor interactomes by an array-based method: discovery of proto-oncoprotein c-Rel as a negative regulator of androgen receptor. (PubMed id 17011549)1, 3 Mukhopadhyay N.K....Liu B.C. (2006)
- Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma. (PubMed id 12511414)1, 3 Barth T.F....Mooller P. (2003)
- Regulation of c-Rel nuclear localization by binding of Ca2+/calmodulin. (PubMed id 12556500)1, 3 Antonsson A....Grundstrom T. (2003)
- Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma. (PubMed id 11830502)1, 3 Martin-Subero J.I....Siebert R. (2002)
- Tumor necrosis factor-alpha activation of NF-kappa B requires the phosphorylation of Ser-471 in the transactivation domain of c-Rel. (PubMed id 10823840)1, 4 Martin A.G. and Fresno M. (2000)
- X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2. (PubMed id 11587641)1, 3 Huang D.B....Ghosh G. (2001)
- Functional interaction of the v-Rel and c-Rel oncoproteins with the TATA-binding protein and association with transcription factor IIB. (PubMed id 8413269)1, 3 Xu X....Gelinas C. (1993)
- TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105. (PubMed id 9950430)1, 3 Belich M.P.... Ley S.C. (1999)
- Aberrant rel/nfkb genes and activity in human cancer. (PubMed id 10602468)1, 3 Rayet B. and Gelinas C. (1999)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)3 Trynka G....Wijmenga C. (2009)
- Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype. (PubMed id 18089804)3 Belguise K....Sonenshein G.E. (2007)
- Gains of REL in primary mediastinal B-cell lymphoma coincide with nuclear accumulation of REL protein. (PubMed id 17243160)3 Weniger M.A....Barth T.F. (2007)
- Gene expression analysis of angioimmunoblastic lymphoma indicates derivation from T follicular helper cells and vascular endothelial growth factor deregulation. (PubMed id 18006812)3 Piccaluga P.P....Pileri S.A. (2007)
- Leishmania major amastigotes induce p50/c-Rel NF-kappa B transcription factor in human macrophages: involvement in cytokine synthesis. (PubMed id 15102766)4 Guizani-Tabbane L.... Dellagi K. (2004)
- Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells. (PubMed id 15143182)3 O'Connor S....Miyamoto S. (2004)
- A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)3 Bouwmeester T....Superti-Furga G. (2004)
- Relationship between REL amplification, REL function, and clinical and biologic features in diffuse large B-cell lymphomas. (PubMed id 14615382)3 Houldsworth J....Chaganti R.S. (2004)
- Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2. (PubMed id 12478664)3 Joos S....Jauch A. (2003)
- Mechanisms of Bcr-Abl-mediated NF-kappaB/Rel activation. (PubMed id 12829026)3 Kirchner D....Munzert G. (2003)
- Mutations in the v-Rel transactivation domain indicate altered phosphorylation and identify a subset of NF-kappaB-regulated cell death inhibitors important for v-Rel transforming activity. (PubMed id 12588973)3 Rayet B....Gelinas C. (2003)
- Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)3 Matsuda A....Sugano S. (2003)
- B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-kappaB regulated c-myc transcription. (PubMed id 12504005)3 Grumont R.J....Gerondakis S. (2002)
- Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2. (PubMed id 11830490)3 Joos S....Barth T.F. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- HIV-1 Tat inhibits IL-2 gene transcription through qualitative and quantitative alterations of the cooperative Rel/AP1 complex bound to the CD28RE/AP1 composite element of the IL-2 promoter. (PubMed id 11254713)3 Gonzalez E....Fresno M. (2001)
- A functional role of I kappa B-epsilon in endothelial cell activation. (PubMed id 10706725)3 Spiecker M....Liao J.K. (2000)
- Constitutive silencing of IFN-beta promoter is mediated by NRF (NF- kB-repressing factor), a nuclear inhibitor of NF-kB. (PubMed id 10562553)3 Nourbakhsh M. and Hauser H. (1999)
- NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2. (PubMed id 10498867)3 Yang J.-P.... Okamoto T. (1999)
- Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. (PubMed id 10329626)3 Bash J....Gelinas C. (1999)
- Chromosomal and gene amplification in diffuse large B-cell lymphoma. (PubMed id 9639522)3 Rao P.H....Chaganti R.S. (1998)
- Association of Cdk2/cyclin E and NF-kappa B complexes at G1/S phase. (PubMed id 9731206)3 Chen E. and Li C.C. (1998)
- Cloning and transcription factor-binding sites of the human c-rel proto-oncogene promoter. (PubMed id 8666258)3 Viswanathan M....Yunis J.J. (1996)
- Activation of the serum response factor by p65/NF-kappaB. (PubMed id 8670842)3 Franzoso G....Siebenlist U. (1996)
- Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf- 1, HMG-I(Y), and NF-kappa B family proteins. (PubMed id 7862168)3 John S....Leonard W.J. (1995)
- Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers. (PubMed id 7929355)3 Mackman N. (1994)
- Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization. (PubMed id 8423996)3 Mathew S....Chaganti R.S. (1993)
- NF-kappa B p100 (Lyt-10) is a component of H2TF1 and can function as an I kappa B-like molecule. (PubMed id 8413211)3 Scheinman R.I....Baldwin A.S. (1993)
- The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein. (PubMed id 1620118)3 Kumar S....Gelinas C. (1992)
- Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products. (PubMed id 1727488)3 Muchardt C....Gaynor R.B. (1992)
- The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70. (PubMed id 2155506)3 Lim M.Y....Bose H.R. (1990)
- Comparative genetic mapping of cellular rel sequences in man, mouse, and the domestic cat. (PubMed id 3529946)3 Brownell E....O'Brien S.J. (1986)
- Mouse mammary tumor virus c-rel transgenic mice develop mammary tumors. (PubMed id 12897145)1 Romieu-Mourez R....Sonenshein G.E. (2003)
- c-Rel is required for chromatin remodeling across the IL-2 gene promoter. (PubMed id 12646638)1 Rao S....Shannon M.F. (2003)
- Repression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocyte transformation by rel proteins. (PubMed id 18245482)1 Gupta N....Gelinas C. (2008)
- I kappa B-alpha-mediated inhibition of nuclear transport and DNA-binding by Rel proteins are separable functions: phosphorylation of C-terminal serine residues of I kappa B-alpha is specifically required for inhibition of DNA-binding. (PubMed id 7675442)1 Sachdev S....Hannink M. (1995)
- Transcription factor c-Rel enhances C-reactive protein expression by facilitating the binding of C/EBPbeta to the promoter. (PubMed id 14522018)1 Agrawal A....Kushner I. (2003)
- Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappa B p65 and c-Rel proteins bound to the NF-kappa B binding site and activates transcription. (PubMed id 7936632)1 Suzuki T....Yoshida M. (1994)
- The rel gene and its role in oncogenesis. (PubMed id 2103511)1 Enrietto P.J. (1990)
- Mutation of an IKK phosphorylation site within the transactivation domain of REL in two patients with B-cell lymphoma enhances REL's in vitro transforming activity. (PubMed id 17072339)1 Starczynowski D.T....Gilmore T.D. (2007)
- Expression of TRAF1 and nuclear c-Rel distinguishes primary mediastinal large cell lymphoma from other types of diffuse large B-cell lymphoma. (PubMed id 17197926)1 Rodig S.J....Kutok J.L. (2007)
- Synergistic and opposing regulation of the stress-responsive gene IEX-1 by p53, c-Myc, and multiple NF-kappaB/rel complexes. (PubMed id 12360408)1 Huang Y.H....Wu M.X. (2002)
- Normal structure of NFKB2, C-REL and BCL-3 gene loci in lymphoproliferative and myeloproliferative disorders. (PubMed id 10830747)1 Munzert G....Bergmann L. (2000)
- The avian transcription factor c-Rel is expressed in lymphocyte precursor cells and antigen-presenting cells during thymus development. (PubMed id 9814582)1 Huguet C....Abbadie C. (1998)
- BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells. (PubMed id 8702216)1 Neumann M....Franza B.R. (1996)
- The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65. (PubMed id 8383323)1 Ghosh P....Young H.A. (1993)
- IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma. (PubMed id 17138822)1 Ramos J.C....Harrington W.J. (2007)
- A chicken c-Rel-estrogen receptor chimeric protein shows conditional nuclear localization, DNA binding, transformation and transcriptional activation. (PubMed id 9671392)1 Zurovec M....Enrietto P.J. (1998)
- Distinct domains of the RelA NF-kappaB subunit are required for negative cross-talk and direct interaction with the glucocorticoid receptor. (PubMed id 9268377)1 Wissink S....van der Saag P.T. (1997)
- High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters. (PubMed id 8934574)1 Himes S.R....Shannon M.F. (1996)
- Differential regulation of c-Rel translocation in activated B and T cells. (PubMed id 8757620)1 Venkataraman L....Sen R. (1996)
- Retrovirus-mediated transfer of nuclear factor-kappa B subunit genes modulates I kappa B alpha and interferon beta expression. (PubMed id 8547225)1 Bitar R....Hiscott J. (1995)
- Differential regulation of the c-myc oncogene promoter by the NF-kappa B rel family of transcription factors. (PubMed id 8289784)1 La Rosa F.A....Sonenshein G.E. (1994)
- Evidence for a non-alpha-helical DNA-binding motif in the Rel homology region. (PubMed id 8302865)1 Liu J....Verdine G.L. (1994)
- Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-kappa B signalling pathway. (PubMed id 8108127)1 Lanoix J....Hiscott J. (1994)
- The transcriptionally active factors mediating the effect of the HTLV-I Tax transactivator on the IL-2R alpha kappa B enhancer include the product of the c-rel proto-oncogene. (PubMed id 8455941)1 Crenon I....Jalinot P. (1993)
- c-rel activates but v-rel suppresses transcription from kappa B sites. (PubMed id 2023921)1 Inoue J....Verma I.M. (1991)
- [Expression of apoptosis-related proteins in the human bone marrow hematopoietic cells treated by Panax Notoginosides] (PubMed id 16638211)1 Chen X.H....Xu W.H. (2006)
- Mutations of tumor necrosis factor alpha-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability. (PubMed id 16027730)1 Starczynowski D.T....Gilmore T.D. (2005)
- c-Rel is a selective activator of a novel IL-4/CD40 responsive element in the human Ig gamma4 germline promoter. (PubMed id 11922943)1 Agresti A. and Vercelli D. (2002)
- Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. (PubMed id 11058167)1 Sanjabi S....Smale S.T. (2000)
- Regulated nuclear import of Rel proteins in the Drosophila immune response. (PubMed id 9510254)1 Wu L.P. and Anderson K.V. (1998)
- Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. (PubMed id 9234715)1 Plevy S.E....Smale S.T. (1997)
- Basal phosphorylation of the PEST domain in the I(kappa)B(beta) regulates its functional interaction with the c-rel proto-oncogene product. (PubMed id 8887627)1 Chu Z.L....Ballard D.W. (1996)
- The structure of the NF-kappa B p50:DNA-complex: a starting point for analyzing the Rel family. (PubMed id 7641872)1 Muller C.W. and Harrison S.C. (1995)
- The viral and cellular Rel oncoproteins induce the differentiation of P19 embryonal carcinoma cells. (PubMed id 8302572)1 Inuzuka M....Ito Y. (1994)
- The Rel family of proteins in oncogenesis and differentiation. (PubMed id 8061327)1 Kabrun N. and Enrietto P.J. (1994)
- Binding of C/EBPbeta to the C-reactive protein (CRP) promoter in Hep3B cells is associated with transcription of CRP mRNA. (PubMed id 18684932)1 Young D.P....Samols D. (2008)
- Characterization of target genes at the 2p15-16 amplicon in diffuse large B-cell lymphoma. (PubMed id 16734728)1 Fukuhara N....Seto M. (2006)
- Nuclear localisation of nuclear factor-kappaB transcription factors in prostate cancer: an immunohistochemical study. (PubMed id 16205698)1 Lessard L....Saad F. (2005)
- Divergent C-terminal transactivation domains of Rel/NF-kappa B proteins are critical determinants of their oncogenic potential in lymphocytes. (PubMed id 14647412)1 Fan Y....Gelinas C. (2004)
- Multiple domains of TonEBP cooperate to stimulate transcription in response to hypertonicity. (PubMed id 12970349)1 Lee S.D....Kwon H.M. (2003)
- Molecular evolution of the NF-kappaB signaling system. (PubMed id 11862396)1 Friedman R. and Hughes A.L. (2002)
- Three mutations in v-Rel render it resistant to cleavage by cell-death protease caspase-3. (PubMed id 11287119)1 Barkett M....Gilmore T.D. (2001)
- Increased expression of c-rel, from the NF-kappaB/Rel family, in T cells from patients with systemic lupus erythematosus. (PubMed id 10648027)1 Burgos P....Gonzalez A. (2000)
- Role and regulation of Rel/NF-kappaB activity in anti-immunoglobulin-induced apoptosis in WEHI-231 B lymphoma cells. (PubMed id 10781932)1 Ku P.T....Bose H.R. (2000)
- UVB-induced association of tumor necrosis factor (TNF) receptor 1/TNF receptor-associated factor-2 mediates activation of Rel proteins. (PubMed id 9435232)1 Tobin D....Toftgard R. (1998)
- Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons. (PubMed id 9852573)1 Maggirwar S.B....Freeman R.S. (1998)
- NF-kappa B/Rel family members regulating the ICAM-1 promoter in monocytic THP-1 cells. (PubMed id 9442377)1 Wissink S....van der Saag P.T. (1997)
- Multiple redox regulation in NF-kappaB transcription factor activation. (PubMed id 9426183)1 Piette J....Bours V. (1997)
- Structural and functional analysis of NF-kappa B. Determinants of DNA binding specificity and protein interaction. (PubMed id 7798213)1 Schmid R.M....Nabel G.J. (1994)
- Distribution of Xrel in the early Xenopus embryo: a cytoplasmic and nuclear gradient. (PubMed id 8082650)1 Bearer E.L. (1994)
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