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Aliases for REL Gene

Aliases for REL Gene

  • V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog 2 3
  • Oncogene REL, Avian Reticuloendotheliosis 3
  • Proto-Oncogene C-Rel 3
  • C-Rel 3

External Ids for REL Gene

Previous GeneCards Identifiers for REL Gene

  • GC02P061237
  • GC02P061067
  • GC02P061083
  • GC02P061020
  • GC02P061108
  • GC02P060851

Summaries for REL Gene

Entrez Gene Summary for REL Gene

  • This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

GeneCards Summary for REL Gene

REL (V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog) is a Protein Coding gene. Diseases associated with REL include nodular lymphocyte predominant hodgkin lymphoma and hypersplenism. Among its related pathways are Ras signaling pathway and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFKB1.

UniProtKB/Swiss-Prot for REL Gene

  • Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator

Gene Wiki entry for REL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REL Gene

Genomics for REL Gene

Regulatory Elements for REL Gene

Genomic Location for REL Gene

Start:
60,881,521 bp from pter
End:
60,944,284 bp from pter
Size:
62,764 bases
Orientation:
Plus strand

Genomic View for REL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REL Gene

Proteins for REL Gene

  • Protein details for REL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04864-REL_HUMAN
    Recommended name:
    Proto-oncogene c-Rel
    Protein Accession:
    Q04864
    Secondary Accessions:
    • Q17RU2
    • Q2PNZ7
    • Q6LDY0

    Protein attributes for REL Gene

    Size:
    619 amino acids
    Molecular mass:
    68520 Da
    Quaternary structure:
    • Component of the NF-kappa-B p65-c-Rel complex. Component of the NF-kappa-B p50-c-Rel complex. Component of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex (By similarity). Interacts with NKIRAS1. Interacts with NFKBIB (By similarity). Interacts with NFKBIE.

    Alternative splice isoforms for REL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REL Gene

Proteomics data for REL Gene at MOPED

Post-translational modifications for REL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for REL (REL)

No data available for DME Specific Peptides for REL Gene

Domains for REL Gene

Suggested Antigen Peptide Sequences for REL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q04864

UniProtKB/Swiss-Prot:

REL_HUMAN :
  • Q04864
Domain:
  • Contains 1 RHD (Rel-like) domain.
genes like me logo Genes that share domains with REL: view

No data available for Gene Families for REL Gene

Function for REL Gene

Molecular function for REL Gene

GENATLAS Biochemistry: avian reticuloendotheliosis viral (v-rel) oncogene homolog,involved in lymphomagenesis (diffuse large B cell lymphoma)
UniProtKB/Swiss-Prot Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator

Gene Ontology (GO) - Molecular Function for REL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 1406630
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 1406630
GO:0003682 chromatin binding IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 8423996
GO:0005515 protein binding IPI 14743216
genes like me logo Genes that share ontologies with REL: view
genes like me logo Genes that share phenotypes with REL: view

Animal Models for REL Gene

MGI Knock Outs for REL:

Animal Model Products

CRISPR Products

miRNA for REL Gene

miRTarBase miRNAs that target REL

Transcription Factor Targeting for REL Gene

Selected GeneGlobe predicted Target genes for REL

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for REL Gene

Localization for REL Gene

Subcellular locations from UniProtKB/Swiss-Prot for REL Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REL Gene COMPARTMENTS Subcellular localization image for REL gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for REL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 22065573
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with REL: view

Pathways for REL Gene

genes like me logo Genes that share pathways with REL: view

PCR Array Products

Gene Ontology (GO) - Biological Process for REL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0001816 cytokine production IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006954 inflammatory response IBA --
genes like me logo Genes that share ontologies with REL: view

Compounds for REL Gene

(21) Novoseek inferred chemical compound relationships for REL Gene

Compound -log(P) Hits PubMed IDs
manganese superoxide 22.7 1
rantes 20.2 1
tacrolimus 18.6 2
chloramphenicol 14.3 2
oligonucleotide 11.8 7
genes like me logo Genes that share compounds with REL: view

Transcripts for REL Gene

Unigene Clusters for REL Gene

V-rel reticuloendotheliosis viral oncogene homolog (avian):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REL

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for REL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REL Gene

No ASD Table

Relevant External Links for REL Gene

GeneLoc Exon Structure for
REL
ECgene alternative splicing isoforms for
REL

Expression for REL Gene

mRNA expression in normal human tissues for REL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REL Gene

This gene is overexpressed in Whole Blood (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for REL Gene

SOURCE GeneReport for Unigene cluster for REL Gene Hs.631886

genes like me logo Genes that share expressions with REL: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for REL Gene

Orthologs for REL Gene

This gene was present in the common ancestor of animals.

Orthologs for REL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REL 35
  • 99.66 (n)
  • 99.32 (a)
REL 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia REL 35
  • 89.46 (n)
  • 84.96 (a)
REL 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia REL 35
  • 89.69 (n)
  • 87.11 (a)
REL 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rel 35
  • 82.22 (n)
  • 76.67 (a)
Rel 16
Rel 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia REL 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia REL 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rel 35
  • 78.27 (n)
  • 75.51 (a)
chicken
(Gallus gallus)
Aves REL 35
  • 62.79 (n)
  • 57.67 (a)
REL 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia REL 36
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rel-A 35
zebrafish
(Danio rerio)
Actinopterygii rel 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dif 36
  • 15 (a)
ManyToMany
dl 36
  • 16 (a)
ManyToMany
dl 37
  • 46 (a)
Dif 37
  • 39 (a)
Rel 37
  • 37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.770 35
Species with no ortholog for REL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for REL Gene

ENSEMBL:
Gene Tree for REL (if available)
TreeFam:
Gene Tree for REL (if available)

Paralogs for REL Gene

Paralogs for REL Gene

Selected SIMAP similar genes for REL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with REL: view

Variants for REL Gene

Sequence variations from dbSNP and Humsavar for REL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs842616 -- 60,909,363(+) TACAT(A/C)GGGGA intron-variant
rs842617 -- 60,910,887(+) agatc(A/G)caaca intron-variant
rs842618 -- 60,917,717(+) GTGTA(C/T)GTGTG intron-variant
rs842619 -- 60,919,204(+) GTGTG(A/G)TAAGA intron-variant
rs842620 -- 60,899,490(+) AAAAA(A/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REL Gene

Variant ID Type Subtype PubMed ID
nsv834215 CNV Loss 17160897
nsv524802 CNV Loss 19592680
nsv874210 CNV Gain 21882294
nsv2749 CNV Insertion 18451855

Relevant External Links for REL Gene

HapMap Linkage Disequilibrium report
REL
Human Gene Mutation Database (HGMD)
REL

PCR Panel Products

  • Copy Number PCR Panels: for REL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REL Gene

Disorders for REL Gene

(2) University of Copenhagen DISEASES for REL Gene

(24) Novoseek inferred disease relationships for REL Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 55.9 3
reticuloendotheliosis 54.8 2
lymphoma b-cell 45.1 13
htlv-i infections 37.3 1
response acute phase 36 1

Relevant External Links for REL

Genetic Association Database (GAD)
REL
Human Genome Epidemiology (HuGE) Navigator
REL
Tumor Gene Database (TGDB):
REL
genes like me logo Genes that share disorders with REL: view

No data available for UniProtKB/Swiss-Prot for REL Gene

Publications for REL Gene

  1. Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor. (PMID: 8152812) Beg A.A. … Baldwin A.S. Jr. (Oncogene 1994) 3 4 23
  2. Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-kappa B. (PMID: 1437141) Neumann M. … Franza B.R. (Oncogene 1992) 3 23
  3. Functional interaction of the v-Rel and c-Rel oncoproteins with the TATA-binding protein and association with transcription factor IIB. (PMID: 8413269) Xu X. … GAclinas C. (Mol. Cell. Biol. 1993) 3 23
  4. I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif. (PMID: 8415639) Kumar S. … GAclinas C. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 23
  5. Differential expression of Rel family members in human T-cell leukemia virus type I-infected cells: transcriptional activation of c-rel by Tax protein. (PMID: 8510222) Li C.C. … Longo D.L. (J. Virol. 1993) 3 23

Products for REL Gene

  • Addgene plasmids for REL

Sources for REL Gene

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