REL Gene
protein-coding GIFtS: 65
GCID: GC02P061108
|
|
v-rel reticuloendotheliosis viral oncogene homolog (avian)(Previous name: v-rel avian reticuloendotheliosis viral oncogene homolog...)
| |
Aliases
for REL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| V-Rel Reticuloendotheliosis Viral Oncogene Homolog (Avian)1 2 | | C-Rel2 | | V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog1 2 | | C-Rel Proto-Oncogene Protein2 | | I-Rel1 | | Oncogene REL, Avian Reticuloendotheliosis2 | | C-Rel2 | | Proto-Oncogene C-Rel2 |
Export aliases for REL gene to outside databasesPrevious GC identifers: GC02P061237 GC02P061067 GC02P061083 GC02P061020 GC02P060851 |
Summaries
for REL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for REL:
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA(MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highlyconserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclearlocalization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 (PubMed18037997)).(supplied by OMIM, May 2008)
UniProtKB/Swiss-Prot: REL_HUMAN, Q04864Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropictranscription factor which is present in almost all cell types and is involved in many biological processed such asinflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- orheterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL andNFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinctpreferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Differentdimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by variousmechanisms of post-translational modification and subcellular compartmentalization as well as by interactions withother cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed withmembers of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B isphosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberatingthe active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is atranscriptional activator
Gene Wiki entry for REL
|
Genomic Views
for REL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the REL gene promoter:
AREB6 C/EBPbeta Sp1 AP-1 ATF-2 IRF-7A IRF-1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for REL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p13-p12 Ensembl cytogenetic band: 2p16.1 HGNC cytogenetic band: 2p13-p12REL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P061108: view genomic region
(about GC identifiers)
Start:
|
61,108,656 bp from pter |
End:
|
61,150,645 bp from pter |
Size:
|
41,990 bases |
Orientation:
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plus strand |
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Proteins
for REL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: REL_HUMAN, Q04864 (See
protein sequence)Recommended Name: Proto-oncogene c-Rel Size: 619 amino acids; 68520 Da
Subunit: Component of the NF-kappa-B p65-c-Rel complex. Component of the NF-kappa-B p50-c-Rel complex. Component of theNF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex (By similarity). Interactswith NKIRAS1. Interacts with NFKBIB (By similarity). Interacts with NFKBIE
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q2PNZ7 Q6LDY0Explore the universe of human proteins at neXtProt for REL: NX_Q04864
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q04864
REL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002899.1
ENSEMBL proteins: ENSP00000295025 ENSP00000377989 Reactome Protein details: Q04864
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
REL for ontologies About GeneDecksing
REL Antibody Products:
Assay Products for REL: |
Protein
Domains /
Families
for REL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
REL for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q04864ProtoNet protein and cluster: Q04864 3 Blocks protein families: IPB000451 NF-kappa-B/Rel/dorsal family IPB002909 Cell surface receptor IPT/TIG IPB011539 Rel homology
UniProtKB/Swiss-Prot: REL_HUMAN, Q04864Similarity: Contains 1 RHD (Rel-like) domain |
Function
for REL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: REL_HUMAN, Q04864Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropictranscription factor which is present in almost all cell types and is involved in many biological processed such asinflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- orheterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL andNFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinctpreferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Differentdimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by variousmechanisms of post-translational modification and subcellular compartmentalization as well as by interactions withother cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed withmembers of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B isphosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberatingthe active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is atranscriptional activator Genatlas biochemistry entry for REL:avian reticuloendotheliosis viral (v-rel) oncogene homolog,involved in lymphomagenesis (diffuse large B cell lymphoma)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REL (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): REL (NM_002725) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for REL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REL |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
REL for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for REL:
Animal Models:
Mouse knock-outs for REL: Reltm1Hcl Reltm1Grd Reltm1Brv
14 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Rel):
REL for phenotypes About GeneDecksing
|
Pathways & Interactions
for REL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/52 super-pathways (see all 52) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_A3 receptor signaling | | | 2 | Mucin expression in CF via IL-6, IL-17 signaling pathways | | | 3 | Development_PDGF signaling via STATs and NF-kB | | | 4 | Development_A2B receptor- action via G-protein alpha s | | | 5 | Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/39 EMD Millipore Pathways for REL (see all 39)
3  R&D Systems Pathways for REL
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for REL
1 
Cell Signaling Technology (CST) Pathway for REL
5/46  GeneGo (Thomson Reuters) Pathways for REL (see all 46)
5/6  BioSystems Pathways for REL (see all 6)
5/8 
Reactome Pathways for REL (see all 8)
1  PharmGKB Pathway for REL
REL for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for REL
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/79 Interacting proteins for REL (Q048641, 2, 3 ENSP000002950254) via UniProtKB, MINT, STRING, and/or I2D (see all 79)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| NFKB1 | P198382, 3, ENSP000002265744 | MINT-6178520 MINT-48666 MINT-6178504 MINT-47884 MINT-48548 MINT-47902 MINT-6178544 I2D:
score=6 STRING: ENSP00000226574 | | NFKB2 | Q006532, 3, ENSP000001894444 | MINT-48598 MINT-6178520 MINT-47915 MINT-48733 MINT-6178504 MINT-47893 MINT-6178544 I2D:
score=6 STRING: ENSP00000189444 | | NFKBIE | O002212, 3, ENSP000002750154 | MINT-47875 I2D:
score=6 STRING: ENSP00000275015 | | PAPOLA | P510032, 3, ENSP000002162774 | MINT-47832 I2D:
score=3 STRING: ENSP00000216277 | | COMMD1 | Q8N6681, 3, ENSP000003082364 | EBI-307352,EBI-1550112 I2D:
score=1 STRING: ENSP00000308236 |
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001816 | cytokine production |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade |
IEP | 12761501 | | GO:0045084 | positive regulation of interleukin-12 biosynthetic process |
IEA | -- |
REL for ontologies About GeneDecksing
|
Drugs & Compounds
for REL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
REL for compounds About GeneDecksing
 Browse Tocris compounds for REL
10/21 Novoseek chemical compound relationships for REL gene (see all 21) About this table
Search CenterWatch for drugs/clinical trials and news about REL
|
Transcripts
for REL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for REL gene: NM_002908.2 Unigene Cluster for REL: V-rel reticuloendotheliosis viral oncogene homolog (avian) Hs.631886 [show with all ESTs]Unigene Representative Sequence: NM_0029082 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000295025(uc002sam.1 uc002san.1) ENST00000394479
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REL (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): REL (NM_002725) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for REL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REL |
Additional cDNA sequence: AK303926.1 BC051005.1 BC117191.1 BC143885.1 X75042.1 4 DOTS entries: DT.311516 DT.100009811 DT.95360644 DT.91984554 24/37 AceView cDNA sequences (see all 37): BX111941 N56815 BF115212 BF446716 AI910463 BE217899 AA279919 BM457679 NM_002908 AI917588 X75042 BF445023 AA122307 CD640399 BG431685 AW206098 AW206529 BC051005 AA827904 BE814107 BU657110 AI247359 AI760025 AA947855
GeneLoc Exon Structure
|
Expression
for REL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| REL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See REL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for REL
SOURCE GeneReport for Unigene cluster: Hs.631886
SABiosciences Expression via Pathway-Focused PCR Arrays including REL (see all 7):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REL |
Orthologs
for REL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for REL gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
REL1 |
v-rel reticuloendotheliosis viral oncogene homolog more |
62.57(n)
56.49(a) |
|
396500 NM_001167726.1 NP_001161198.1 |
lizard
(Anolis carolinensis) |
Reptilia |
REL6 |
-- |
48(a) |
1 ↔ 1 |
GL343523.1(438329-480999) |
African clawed frog
(Xenopus laevis) |
Amphibia |
rel-A2 |
v-rel reticuloendotheliosis viral oncogene homolog more |
76.22(n) |
|
Z49252.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rel6 |
v-rel reticuloendotheliosis viral oncogene homolog... |
43(a) |
1 ↔ 1 |
13(26019401-26043715) |
fruit fly
(Drosophila melanogaster) |
Insecta |
dl3 |
immune response transcription factor |
46(a)
(best of 3) |
|
-- |
ENSEMBL Gene Tree for REL (if available)
TreeFam Gene Tree for REL (if available) |
Paralogs
for REL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for REL gene
- NFKB12 NFKB22 RELB2 RELA2
3 SIMAP similar genes for REL using alignment to 2 protein entries: REL_HUMAN (see all proteins):RELA RELB NFKB2
REL for paralogs About GeneDecksing
|
Genomic Variants
for REL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for REL (61108656 - 61150645 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for REL
3 CNVs: 2386 3361 8373
1 Indel: 40333
Human Gene Mutation Database (HGMD): REL
| SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing REL: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REL |
|
Disorders
/ Diseases
for REL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
REL for disorders About GeneDecksing
OMIM gene information: 164910
OMIM disorders: --
20/39  diseases for REL (see all 39): About MalaCardsdiffuse large b-cell lymphoma human t-cell leukemia virus type 1 sclerosing cholangitis b-cell lymphomas
primary sclerosing cholangitis non-hodgkin lymphoma cholangitis systemic lupus erythematosus
lupus erythematosus hodgkin's lymphoma adult t-cell leukemia atopic dermatitis
histoplasmosis chronic lymphocytic leukemia myeloproliferative disorder lymphocytic leukemia
leukemia/lymphoma ulcerative colitis t-cell leukemia dermatitis
2 diseases from the University of Copenhagen DISEASES database for REL:Lymphoma Leukemia 10/24 Novoseek disease relationships for REL gene (see all 24) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia t-cell |
55.9 |
4 |
7935451 (1), 9247567 (1), 8510222 (1) |
| reticuloendotheliosis |
54.8 |
2 |
1848011 (1), 15870177 (1) |
| lymphoma b-cell |
45.1 |
18 |
17072339 (4), 16027730 (2), 17197926 (2), 15644776 (2) (see all 7) |
| htlv-i infections |
37.3 |
1 |
8627746 (1) |
| response acute phase |
36 |
1 |
14530385 (1) |
| necrosis |
33.2 |
5 |
8152812 (1), 9435232 (1), 8621542 (1), 10823840 (1) (see all 5) |
| hodgkin disease |
26.5 |
11 |
15644776 (4), 14755244 (1), 18245482 (1), 15870177 (1) (see all 5) |
| inflammation |
26.5 |
3 |
15110174 (1), 12857966 (1), 19347041 (1) |
| tumors |
19.7 |
19 |
17138822 (3), 12897145 (2), 9435232 (1), 10602468 (1) (see all 16) |
| immunodeficiency |
19 |
4 |
1493333 (1), 8394446 (1), 15917220 (1), 1741161 (1) |
Human Genome Epidemiology (HuGE) Navigator: REL (28 documents)
Tumor Gene Database (TGDB): REL
Export disorders for REL gene to outside databases
|
Publications
for REL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for REL gene, integrated from 9 sources (see all 317):
(articles sorted by number of sources associating them with REL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor. (PubMed id 8152812)1, 2, 9 Beg A.A. and Baldwin A.S. Jr. (1994)
- Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. (PubMed id 15024091)1, 2 Chen Y.... Ghosh G. (2004)
- A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. (PubMed id 9315679)1, 2 Li Z. and Nabel G.J. (1997)
- A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene. (PubMed id 1740106)1, 2 Hansen S.K....Blasi F. (1992)
- I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. (PubMed id 1577270)1, 3 Ruben S.M....Rosen C.A. (1992)
- A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon. (PubMed id 2666912)1, 2 Brownell E.... Rice N.R. (1989)
- Genetic characterization of human c-rel sequences. (PubMed id 3016517)1, 2 Brownell E.... Rice N.R. (1985)
- Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation. (PubMed id 8621542)1, 9 Meyer C.F....Tan T.H. (1996)
- Deficient translocation of c-Rel is associated with impaired Th1 cytokine production in T cells from atopic dermatitis patients. (PubMed id 15660915)1, 9 Dieckhoff K....Jung T. (2005)
- Unraveling androgen receptor interactomes by an array-based method: discovery of proto-oncoprotein c-Rel as a negative regulator of androgen receptor. (PubMed id 17011549)1, 9 Mukhopadhyay N.K....Liu B.C. (2006)
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External Searches for REL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing REL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing REL gene
(According to HUGE)
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Specialized Databases showing REL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for REL gene:
Search GeneIP for patents involving REL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for REL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for REL | | OriGene shRNA RFP for REL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REL | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for REL | | OriGene 3'-UTR Clone for REL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for REL | | OriGene Custom Protein Services for REL | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat REL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REL |
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| | Antibodies & Assays for REL |
| | | | Search Tocris compounds for REL |
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 | | | REL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REL |
|  |  |  | | | | ThermoFisher Antibody for REL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REL |
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