Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



REL Gene

protein-coding   GIFtS: 68
GCID: GC02P061108

V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog

  See REL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog1 2
C-Rel2
C-Rel Proto-Oncogene Protein2
Oncogene REL, Avian Reticuloendotheliosis2
Proto-Oncogene C-Rel2
V-Rel Reticuloendotheliosis Viral Oncogene Homolog2

External Ids:    HGNC: 99541   Entrez Gene: 59662   Ensembl: ENSG000001629247   OMIM: 1649105   UniProtKB: Q048643   

Export aliases for REL gene to outside databases

Previous GC identifers: GC02P061237 GC02P061067 GC02P061083 GC02P061020 GC02P060851


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for REL Gene:
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes
RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through
a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization,
nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 (PubMed
18037997)).(supplied by OMIM, May 2008)

GeneCards Summary for REL Gene:
REL (v-rel avian reticuloendotheliosis viral oncogene homolog) is a protein-coding gene. Diseases associated with REL include nodular lymphocyte predominant hodgkin lymphoma, and hypersplenism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFKB1.

UniProtKB/Swiss-Prot: REL_HUMAN, Q04864
Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic
transcription factor which is present in almost all cell types and is involved in many biological processed such
as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or
heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers
have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and
specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.
NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular
compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are
held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family.
In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to
different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to
the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator

Gene Wiki entry for REL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the REL gene promoter:
         AREB6   C/EBPbeta   Sp1   AP-1   ATF-2   IRF-7A   IRF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREL promoter sequence
   Search Chromatin IP Primers for REL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13-p12   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p13-p12

REL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REL gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P061108:  view genomic region     (about GC identifiers)

Start:
61,108,656 bp from pter      End:
61,158,745 bp from pter
Size:
50,090 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: REL_HUMAN, Q04864 (See protein sequence)
Recommended Name: Proto-oncogene c-Rel  
Size: 619 amino acids; 68520 Da
Subunit: Component of the NF-kappa-B p65-c-Rel complex. Component of the NF-kappa-B p50-c-Rel complex. Component
of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex (By similarity).
Interacts with NKIRAS1. Interacts with NFKBIB (By similarity). Interacts with NFKBIE
Secondary accessions: Q2PNZ7 Q6LDY0

Explore the universe of human proteins at neXtProt for REL: NX_Q04864

Explore proteomics data for REL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See REL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002899.1  
    ENSEMBL proteins: 
     ENSP00000295025   ENSP00000377989  
    Reactome Protein details: Q04864

    REL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for REL
    GenScript Custom Purified and Recombinant Proteins Services for REL
    Novus Biologicals REL Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for REL

     
    Search eBioscience for Proteins for REL 

    REL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of REL
    R&D Systems Antibodies for REL (c-Rel)
    Cell Signaling Technology (CST) Antibodies for REL 
    OriGene Antibodies for REL
    OriGene Custom Antibody Services for REL
    Novus Biologicals REL Antibodies
    Abcam antibodies for REL
    Cloud-Clone Corp. Antibodies for REL
    ThermoFisher Antibody for REL
    LSBio Antibodies in human, mouse, rat for REL

    REL Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for REL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for REL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for REL
    Cloud-Clone Corp. CLIAs for REL
    Search eBioscience for ELISAs for REL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR014756 Ig_E-set
     IPR008967 p53-like_TF_DNA-bd
     IPR002909 IPT
     IPR013783 Ig-like_fold
     IPR000451 NF_Rel_Dor

    Graphical View of Domain Structure for InterPro Entry Q04864

    ProtoNet protein and cluster: Q04864

    3 Blocks protein domains:
    IPB000451 NF-kappa-B/Rel/dorsal family
    IPB002909 Cell surface receptor IPT/TIG
    IPB011539 Rel homology


    UniProtKB/Swiss-Prot: REL_HUMAN, Q04864
    Similarity: Contains 1 RHD (Rel-like) domain


    Find genes that share domains with REL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REL_HUMAN, Q04864
    Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic
    transcription factor which is present in almost all cell types and is involved in many biological processed such
    as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or
    heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
    REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers
    have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and
    specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.
    NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular
    compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are
    held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family.
    In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to
    different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to
    the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator

         Genatlas biochemistry entry for REL:
    avian reticuloendotheliosis viral (v-rel) oncogene homolog,involved in lymphomagenesis (diffuse large B cell
    lymphoma)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI14743216
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with REL           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for REL:
     Decreased mitotic index 

         14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rel):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  nervous system  respiratory system  skeleton 

    Find genes that share phenotypes with REL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for REL: Reltm1Hcl Reltm1Grd Reltm1Brv

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for REL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for REL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REL

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for REL (see all 220):
    ADCK5,  ADH7,  ALDH4A1,  AMY2B,  ANKRD33,  ANO10,  APOD,  ATP13A3,  BLOC1S3,  BNC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target REL:
    hsa-mir-98-5p (MIRT027520)

    Block miRNA regulation of human, mouse, rat REL using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate REL
    SwitchGear 3'UTR luciferase reporter plasmidREL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for REL
    Predesigned siRNA for gene silencing in human, mouse, rat REL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for REL

    Clone
    Products:
         
    OriGene clones in human, mouse for REL (see all 7)
    OriGene ORF clones in mouse, rat for REL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): REL (NM_002725)
    Sino Biological Human cDNA Clone for REL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REL
    Addgene plasmids for REL 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for REL
    Browse ESI BIO Cell Lines and PureStem Progenitors for REL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    REL_HUMAN, Q04864: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    extracellular2
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with REL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for REL About   (see all 45)  
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39
    3Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    Bacterial infections in CF airways0.78
    Transcription NF kB signaling pathway0.32
    4IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    5Immune response NFAT in immune response
    Immune response NFAT in immune response0.55
    Immune response T cell receptor signaling pathway0.50
    Immune response ICOS pathway in T helper cell0.55
    Immune response CD28 signaling0.49


    Find genes that share SuperPaths with REL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for REL (see all 7)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for REL
        PKR Pathway
    Activation of NF-KappaB by PKR
    NF-KappaB Family Pathway

    1 Cell Signaling Technology (CST) Pathway for REL
        NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for REL (see all 46)
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Development A2A receptor signaling
    Immune response Bacterial infections in normal airways
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    Selected BioSystems Pathways for REL (see all 6)
        TNF-alpha/NF-kB Signaling Pathway
    B Cell Receptor Signaling Pathway
    TCR Signaling Pathway
    Leptin signaling pathway
    Regulation of Androgen receptor activity


    1 Reactome Pathway for REL
        Activation of NF-kappaB in B cells

    1 PharmGKB Pathway for REL
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for REL):
        Ras signaling pathway
    Transcriptional misregulation in cancer
    Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including REL (see all 7): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Transcription Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for REL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for REL (Q048641, 2, 3 ENSP000002950254) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB2Q006531, 2, 3, ENSP000001894444EBI-307352,EBI-307326 MINT-48598 MINT-6178520 MINT-47915 MINT-48733 MINT-6178504 MINT-47893 MINT-6178544 I2D: score=6 STRING: ENSP00000189444
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007249I-kappaB kinase/NF-kappaB signaling IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IEP12761501

    Find genes that share ontologies with REL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for REL

    Selected Novoseek inferred chemical compound relationships for REL gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    manganese superoxide 22.7 1 16027730 (1)
    rantes 20.2 2 10023774 (1)
    tacrolimus 18.6 2 7510691 (1), 8757620 (1)
    chloramphenicol 14.3 3 1903456 (1), 8383323 (1)
    oligonucleotide 11.8 8 1549370 (2), 14522018 (2), 10465241 (1), 9188493 (1) (see all 5)
    phorbol 9.75 1 1741161 (1)
    7,12-dimethylbenz(a)anthracene 9.1 3 11160867 (2)
    serine 6.56 6 7675442 (2), 9837938 (1), 16027730 (1), 17072339 (1)
    nitric oxide 3.06 1 17720813 (1)
    lysine 0 1 18377428 (1)



    Find genes that share compounds with REL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for REL gene: 
    NM_002908.2  

    Unigene Cluster for REL:

    V-rel reticuloendotheliosis viral oncogene homolog (avian)
    Hs.631886  [show with all ESTs]
    Unigene Representative Sequence: NM_002908
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295025(uc002sam.1 uc002san.1) ENST00000394479
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat REL using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate REL
    SwitchGear 3'UTR luciferase reporter plasmidREL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for REL
    Predesigned siRNA for gene silencing in human, mouse, rat REL
    Clone
    Products:
         
    OriGene clones in human, mouse for REL (see all 7)
    OriGene ORF clones in mouse, rat for REL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): REL (NM_002725)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REL
    Addgene plasmids for REL 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for REL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REL
      QuantiTect SYBR Green Assays in human, mouse, rat REL
      QuantiFast Probe-based Assays in human, mouse, rat REL

    Additional mRNA sequence: 

    AK303926.1 BC051005.1 BC117191.1 BC143885.1 X75042.1 

    4 DOTS entries:

    DT.311516  DT.100009811  DT.95360644  DT.91984554 

    Selected AceView cDNA sequences (see all 37):

    AA279919 BM457679 BF446716 BF115212 BX111941 BE217899 AI917588 NM_002908 
    AI910463 X75042 N56815 BC051005 AA122307 CD640399 AW206529 BF445023 
    AA827904 AW206098 BG431685 AA122405 AI247359 BU657110 AI760025 BE814107 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    REL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    REL Expression
    About this image


    REL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    REL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631886
        Pathway & Disease-focused RT2 Profiler PCR Arrays including REL (see all 7): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Transcription Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for REL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REL
    QuantiTect SYBR Green Assays in human, mouse, rat REL
    QuantiFast Probe-based Assays in human, mouse, rat REL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for REL gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rel1 , 5 reticuloendotheliosis oncogene1, 5 82.22(n)1
    76.67(a)1
      11 (14.36 cM)5
    196961  NM_009044.21  NP_033070.21 
     237415145 
    chicken
    (Gallus gallus)
    Aves REL1 v-rel reticuloendotheliosis viral oncogene homolog more 62.79(n)
    57.67(a)
      396500  NM_001167726.1  NP_001161198.1 
    lizard
    (Anolis carolinensis)
    Reptilia REL6
    v-rel avian reticuloendotheliosis viral oncogene h...
    49(a)
    1 ↔ 1
    GL343523.1(438314-481356)
    African clawed frog
    (Xenopus laevis)
    Amphibia rel-A2 v-rel reticuloendotheliosis viral oncogene homolog more 76.22(n)    Z49252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rel6
    v-rel reticuloendotheliosis viral oncogene homolog...
    43(a)
    1 ↔ 1
    13(26019401-26043715) ENSDARG00000055276
    fruit fly
    (Drosophila melanogaster)
    Insecta dl3 immune response transcription factor 46(a)
    (best of 3)
        --


    ENSEMBL Gene Tree for REL (if available)
    TreeFam Gene Tree for REL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for REL gene
    NFKB12  NFKB22  RELB2  RELA2  
    3 SIMAP similar genes for REL using alignment to 2 protein entries:     REL_HUMAN (see all proteins):
    RELA    RELB    NFKB2

    Find genes that share paralogs with REL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for REL (see all 748)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs615900801,2
    C--61003260(+) AAAAA-/A/AA  
            
    CATAA
    1 -- int11NA 2
    rs1886953951,2
    --61110475(+) TTTCAC/TATGAC 1 -- int10--------
    rs802453121,2
    C--61110540(+) TTCAAC/TTTTCC 1 -- int10--------
    rs1422425451,2
    --61110545(+) CTTTCC/TCTTTT 1 -- int10--------
    rs760313131,2
    F--61110771(+) AATACT/GTCTAA 1 -- int11Minor allele frequency- G:0.02WA 118
    rs755525871,2
    C,F--61110879(+) ACTGTA/GTTTTG 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1932855751,2
    --61110929(+) GAAATC/GTTTAA 1 -- int10--------
    rs1850297501,2
    C--61110969(+) TTGAAA/GGGTGA 1 -- int10--------
    rs352318991,2
    C--61111107(+) AAAAA-/ATGTTT 1 -- int10--------
    rs3774559671,2
    C--61111252(+) AAAAA-/GAAATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for REL (61108656 - 61158745 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for REL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2749CNV Insertion18451855
    nsv524802CNV Loss19592680
    nsv834215CNV Loss17160897
    nsv874210CNV Gain21882294

    Human Gene Mutation Database (HGMD): REL
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing REL:
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing REL
    DNA2.0 Custom Variant and Variant Library Synthesis for REL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 164910    OMIM disorders: --

    4 diseases for REL:    
    About MalaCards
    nodular lymphocyte predominant hodgkin lymphoma    hypersplenism    primary mediastinal large b-cell lymphoma    hodgkin's lymphoma

    2 diseases from the University of Copenhagen DISEASES database for REL:
    Lymphoma     Leukemia

    Find genes that share disorders with REL           About GenesLikeMe

    Selected Novoseek inferred disease relationships for REL gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 55.9 4 7935451 (1), 9247567 (1), 8510222 (1)
    reticuloendotheliosis 54.8 2 1848011 (1), 15870177 (1)
    lymphoma b-cell 45.1 18 17072339 (4), 16027730 (2), 17197926 (2), 15644776 (2) (see all 7)
    htlv-i infections 37.3 1 8627746 (1)
    response acute phase 36 1 14530385 (1)
    necrosis 33.2 5 8152812 (1), 9435232 (1), 8621542 (1), 10823840 (1) (see all 5)
    hodgkin disease 26.5 11 15644776 (4), 14755244 (1), 18245482 (1), 15870177 (1) (see all 5)
    inflammation 26.5 3 15110174 (1), 12857966 (1), 19347041 (1)
    tumors 19.7 19 17138822 (3), 12897145 (2), 9435232 (1), 10602468 (1) (see all 16)
    immunodeficiency 19 4 1493333 (1), 8394446 (1), 15917220 (1), 1741161 (1)

    Genetic Association Database (GAD): REL
    Human Genome Epidemiology (HuGE) Navigator: REL (28 documents)
    Tumor Gene Database (TGDB): REL

    Export disorders for REL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for REL gene, integrated from 10 sources (see all 325):
    (articles sorted by number of sources associating them with REL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor. (PubMed id 8152812)1, 2, 9 Beg A.A. and Baldwin A.S. Jr. (Oncogene 1994)
    2. Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL. (PubMed id 22170493)1, 4 Ellinghaus E....Franke A. (J. Invest. Dermatol. 2012)
    3. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    4. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (Nat. Genet. 2010)
    5. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. (PubMed id 20953190)1, 4  ....Trembath R.C. (Nat. Genet. 2010)
    6. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PubMed id 20228799)1, 4 McGovern D.P....Seielstad M. (Nat. Genet. 2010)
    7. Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. (PubMed id 20448286)1, 4 Potter C....Isaacs J.D. (Ann. Rheum. Dis. 2010)
    8. Confirmation of association of the REL locus with rheumatoid arthritis susceptibility in the UK population. (PubMed id 19945995)1, 4 Eyre S....Barton A. (Ann. Rheum. Dis. 2010)
    9. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5966 HGNC: 9954 AceView: REL Ensembl:ENSG00000162924 euGenes: HUgn5966
    ECgene: REL Kegg: 5966 H-InvDB: REL

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for REL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for REL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for REL gene:
    Search GeneIP for patents involving REL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of REL
     
     EMD Millipore genomic analysis products

      
     Antibodies for REL (c-Rel)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for REL   OriGene RNAi products in human, mouse, rat for REL  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for REL  
     OriGene qSTAR qPCR primer pairs in human, mouse for REL   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for REL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for REL   OriGene Custom Protein Services for REL  

     
     
     Block miRNA regulation of human, mouse, rat REL using miScript Target Protectors SeqTarget long-range PCR primers for resequencing REL
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REL Predesigned siRNA for gene silencing in human, mouse, rat REL
     QuantiFast Probe-based Assays in human, mouse, rat REL QuantiTect SYBR Green Assays in human, mouse, rat REL
     PCR Arrays including human, mouse, rat REL Search Chromatin IP Primers for REL
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REL  GeneGlobe Interaction Network for REL
     Regulatory tfbs in REL promoter
     GenScript Custom Purified and Recombinant Proteins Services for REL GenScript cDNA clones with any tag delivered in your preferred vector for REL
     GenScript Custom Assay Services for REL GenScript Custom overexpressing Cell Line Services for REL
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for REL 

     Search Tocris compounds for REL
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for REL
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     REL antibodies
     REL proteins
     Antibodies for REL
     See all of Abcam's Antibodies, Kits and Proteins for REL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for REL
     Antibodies for REL
     ELISAs for REL
     CLIAs for REL



     Browse ESI BIO Cell Lines and PureStem Progenitors for REL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REL
     SwitchGear 3'UTR luciferase reporter plasmids for REL
     SwitchGear Promoter luciferase reporter plasmids for REL
     ThermoFisher Antibody for REL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REL
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for REL
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for REL
     LSBio Antibodies in human, mouse, rat for REL
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for REL
      Search eBioscience for proteins for REL
      Search eBioscience for elisas for REL
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      REL gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4