Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REL Gene

protein-coding   GIFtS: 68
GCID: GC02P061108

V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog1 2
C-Rel2
C-Rel Proto-Oncogene Protein2
Oncogene REL, Avian Reticuloendotheliosis2
Proto-Oncogene C-Rel2
V-Rel Reticuloendotheliosis Viral Oncogene Homolog2

External Ids:    HGNC: 99541   Entrez Gene: 59662   Ensembl: ENSG000001629247   OMIM: 1649105   UniProtKB: Q048643   

Export aliases for REL gene to outside databases

Previous GC identifers: GC02P061237 GC02P061067 GC02P061083 GC02P061020 GC02P060851


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for REL Gene:
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes
RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through
a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization,
nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 (PubMed
18037997)).(supplied by OMIM, May 2008)

GeneCards Summary for REL Gene: 
REL (v-rel avian reticuloendotheliosis viral oncogene homolog) is a protein-coding gene. Diseases associated with REL include nodular lymphocyte predominant hodgkin lymphoma, and histoplasmosis, and among its related super-pathways are Signal transduction AKT signaling and Mucin expression in CF via IL-6, IL-17 signaling pathways. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFKB1.

UniProtKB/Swiss-Prot: REL_HUMAN, Q04864
Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic
transcription factor which is present in almost all cell types and is involved in many biological processed such
as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or
heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers
have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and
specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.
NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular
compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are
held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family.
In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to
different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to
the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator

Gene Wiki entry for REL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REL gene promoter:
         AREB6   C/EBPbeta   Sp1   AP-1   ATF-2   IRF-7A   IRF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREL promoter sequence
   Search SABiosciences Chromatin IP Primers for REL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13-p12   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p13-p12

REL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REL gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P061108:  view genomic region     (about GC identifiers)

Start:
61,108,656 bp from pter      End:
61,150,645 bp from pter
Size:
41,990 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: REL_HUMAN, Q04864 (See protein sequence)
Recommended Name: Proto-oncogene c-Rel  
Size: 619 amino acids; 68520 Da
Subunit: Component of the NF-kappa-B p65-c-Rel complex. Component of the NF-kappa-B p50-c-Rel complex. Component
of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex (By similarity).
Interacts with NKIRAS1. Interacts with NFKBIB (By similarity). Interacts with NFKBIE
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q2PNZ7 Q6LDY0

Explore the universe of human proteins at neXtProt for REL: NX_Q04864

Explore proteomics data for REL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q04864

  • REL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    REL Protein Expression
    REFSEQ proteins: NP_002899.1  
    ENSEMBL proteins: 
     ENSP00000295025   ENSP00000377989  
    Reactome Protein details: Q04864
    Human Recombinant Protein Products for REL: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for REL
    GenScript Custom Purified and Recombinant Proteins Services for REL
    Novus Biologicals REL Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for REL 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    REL for ontologies           About GeneDecksing



    REL Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of REL
    R&D Systems Antibodies for REL (c-Rel)
    Cell Signaling Technology (CST) Antibodies for REL 
    OriGene Antibodies for REL
    OriGene Custom Antibody Services for REL
    GenScript Custom Superior Antibodies Services for REL
    Novus Biologicals REL Antibodies
    Abcam antibodies for REL
    Cloud-Clone Corp. Antibodies for REL 
    ThermoFisher Antibody for REL
    LSBio Antibodies in human, mouse, rat for REL 

    Assay Products for REL: 
    EMD Millipore Kits and Assays for the Analysis of REL
    OriGene Custom Assay Services for REL
    R&D Systems Transcription Factor Binding & Immunoprecipitation Assays for REL (c-Rel)
    GenScript Custom Assay Services for REL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for REL 
    Cloud-Clone Corp. CLIAs for REL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR014756 Ig_E-set
     IPR008967 p53-like_TF_DNA-bd
     IPR002909 IPT_TIG_rcpt
     IPR013783 Ig-like_fold
     IPR000451 NF_Rel_Dor

    Graphical View of Domain Structure for InterPro Entry Q04864

    ProtoNet protein and cluster: Q04864

    3 Blocks protein domains:
    IPB000451 NF-kappa-B/Rel/dorsal family
    IPB002909 Cell surface receptor IPT/TIG
    IPB011539 Rel homology


    UniProtKB/Swiss-Prot: REL_HUMAN, Q04864
    Similarity: Contains 1 RHD (Rel-like) domain


    REL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REL_HUMAN, Q04864
    Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic
    transcription factor which is present in almost all cell types and is involved in many biological processed such
    as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or
    heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
    REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers
    have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and
    specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.
    NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular
    compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are
    held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family.
    In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to
    different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to
    the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator

         Genatlas biochemistry entry for REL:
    avian reticuloendotheliosis viral (v-rel) oncogene homolog,involved in lymphomagenesis (diffuse large B cell
    lymphoma)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI15799966
         
    REL for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for REL:
     Decreased mitotic index 

         14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rel):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  nervous system  respiratory system  skeleton 

    REL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for REL: Reltm1Hcl Reltm1Grd Reltm1Brv

       inGenious Targeting Laboratory - Custom generated mouse model solutions for REL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for REL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REL 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REL
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate REL
    SwitchGear 3'UTR luciferase reporter plasmidREL 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for REL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for REL
    Sirion Biotech Customized adenovirus for overexpression of REL

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for REL (see all 6)
    OriGene ORF clones in mouse, rat for REL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): REL (NM_002725)
    Sino Biological Human cDNA Clone for REL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REL
    Sirion Biotech Customized lentivirus for stable overexpression of REL 
                         Customized lentivirus expression plasmids for stable overexpression of REL 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for REL
    Search LifeMap BioReagents cell lines for REL
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for REL About   (see all 50)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Mucin expression in CF via IL-6, IL-17 signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways0.48
    Mucin expression in CF via TLRs, EGFR signaling pathways0.41
    IL-17 Signaling0.48
    3Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    4Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.91
    Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
    5Toll-Like receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.59
    Inflammasome Activation Pathways0.52
    NOD-like Receptor Signaling Pathways0.59
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/39 EMD Millipore Pathways for REL (see all 39)
        Immune response MIF-mediated glucocorticoid regulation
    Development TGF-beta receptor signaling
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Transcription NF-kB signaling pathway
    Transcription P53 signaling pathway

    5/6 R&D Systems Pathways for REL (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for REL
        PKR Pathway
    Activation of NF-KappaB by PKR
    NF-KappaB Family Pathway

    1 Cell Signaling Technology (CST) Pathway for REL
        NF-kappaB Signaling

    5/46 GeneGo (Thomson Reuters) Pathways for REL (see all 46)
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Development A2A receptor signaling
    Immune response Bacterial infections in normal airways
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    5/6 BioSystems Pathways for REL (see all 6)
        TCR Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    B Cell Receptor Signaling Pathway
    Leptin signaling pathway
    Regulation of Androgen receptor activity


    5        Reactome Pathways for REL
        Downstream Signaling Events Of B Cell Receptor (BCR)
    Adaptive Immune System
    Activation of NF-kappaB in B Cells
    Immune System
    Signaling by the B Cell Receptor (BCR)

    1 PharmGKB Pathway for REL
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for REL):
        Transcriptional misregulation in cancer
    Viral carcinogenesis


    REL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for REL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/96 Interacting proteins for REL (Q048641, 2, 3 ENSP000002950254) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade IEP12761501
    GO:0045084positive regulation of interleukin-12 biosynthetic process IEA--

    REL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    REL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REL

    10/21 Novoseek inferred chemical compound relationships for REL gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    manganese superoxide 22.7 1 16027730 (1)
    rantes 20.2 2 10023774 (1)
    tacrolimus 18.6 2 7510691 (1), 8757620 (1)
    chloramphenicol 14.3 3 1903456 (1), 8383323 (1)
    oligonucleotide 11.8 8 1549370 (2), 14522018 (2), 10465241 (1), 9188493 (1) (see all 5)
    phorbol 9.75 1 1741161 (1)
    7,12-dimethylbenz(a)anthracene 9.1 3 11160867 (2)
    serine 6.56 6 7675442 (2), 9837938 (1), 16027730 (1), 17072339 (1)
    nitric oxide 3.06 1 17720813 (1)
    lysine 0 1 18377428 (1)

    Search CenterWatch for drugs/clinical trials and news about REL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for REL gene: 
    NM_002908.2  

    Unigene Cluster for REL:

    V-rel reticuloendotheliosis viral oncogene homolog (avian)
    Hs.631886  [show with all ESTs]
    Unigene Representative Sequence: NM_002908
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295025(uc002sam.1 uc002san.1) ENST00000394479
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REL
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate REL
    SwitchGear 3'UTR luciferase reporter plasmidREL 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for REL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REL
    Clone
    Products:
         
    OriGene clones in human, mouse for REL (see all 6)
    OriGene ORF clones in mouse, rat for REL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): REL (NM_002725)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REL
    Sirion Biotech Customized lentivirus for stable overexpression of REL 
                         Customized lentivirus expression plasmids for stable overexpression of REL 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for REL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REL

    Additional mRNA sequence: 

    AK303926.1 BC051005.1 BC117191.1 BC143885.1 X75042.1 

    4 DOTS entries:

    DT.311516  DT.100009811  DT.95360644  DT.91984554 

    24/37 AceView cDNA sequences (see all 37):

    AI917588 BF115212 AI910463 AA279919 N56815 X75042 BE217899 BX111941 
    BF446716 NM_002908 BM457679 AA122307 AA827904 BF445023 CD640399 BC051005 
    AW206098 AW206529 BG431685 AI760025 AI247359 AA741446 AA947855 BU657110 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REL expression in normal human tissues (normalized intensities)      REL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    REL Expression
    About this image


    REL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Cerebral Cortex
             Substantia Nigra   
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Blood (Hematopoietic System)
             b cells   
     
     Spinal Cord (Nervous System)
             Ventral Horn   
     
     Lymph (Hematopoietic System)
             LYMPH NODE   

    See REL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REL

    SOURCE GeneReport for Unigene cluster: Hs.631886
        SABiosciences Expression via Pathway-Focused PCR Arrays including REL (see all 7): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Transcription Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for REL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REL
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REL
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for REL gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rel1 , 5 reticuloendotheliosis oncogene1, 5 81.82(n)1
    76.67(a)1
      11 (14.36 cM)5
    196961  NM_009044.21  NP_033070.21 
     237415145 
    chicken
    (Gallus gallus)
    Aves REL1 v-rel reticuloendotheliosis viral oncogene homolog more 62.57(n)
    56.49(a)
      396500  NM_001167726.1  NP_001161198.1 
    lizard
    (Anolis carolinensis)
    Reptilia REL6
    v-rel reticuloendotheliosis viral oncogene homolog...
    41(a)
    1 ↔ 1
    GL343523.1(438314-481356)
    African clawed frog
    (Xenopus laevis)
    Amphibia rel-A2 v-rel reticuloendotheliosis viral oncogene homolog more 76.22(n)    Z49252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rel6
    v-rel reticuloendotheliosis viral oncogene homolog...
    40(a)
    1 ↔ 1
    13(26019401-26043715)
    fruit fly
    (Drosophila melanogaster)
    Insecta dl3 immune response transcription factor 46(a)
    (best of 3)
        --


    ENSEMBL Gene Tree for REL (if available)
    TreeFam Gene Tree for REL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for REL gene
    NFKB12  NFKB22  RELB2  RELA2  
    3 SIMAP similar genes for REL using alignment to 2 protein entries:     REL_HUMAN (see all proteins):
    RELA    RELB    NFKB2

    REL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/748 SNPs in REL are shown (see all 748)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs615900801,2
    C--61003260(+) AAAAA-/A/AA  
            
    CATAA
    1 -- int11NA 2
    rs1886953951,2
    --61110475(+) TTTCAC/TATGAC 1 -- int10--------
    rs802453121,2
    C--61110540(+) TTCAAC/TTTTCC 1 -- int10--------
    rs1422425451,2
    --61110545(+) CTTTCC/TCTTTT 1 -- int10--------
    rs760313131,2
    F--61110771(+) AATACT/GTCTAA 1 -- int11Minor allele frequency- G:0.02WA 118
    rs755525871,2
    C,F--61110879(+) ACTGTA/GTTTTG 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1932855751,2
    --61110929(+) GAAATC/GTTTAA 1 -- int10--------
    rs1850297501,2
    C--61110969(+) TTGAAA/GGGTGA 1 -- int10--------
    rs352318991,2
    C--61111107(+) AAAAA-/ATGTTT 1 -- int10--------
    rs3774559671,2
    C--61111252(+) AAAAA-/GAAATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for REL (61108656 - 61150645 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for REL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2749CNV Insertion18451855
    nsv524802CNV Loss19592680
    nsv834215CNV Loss17160897
    nsv874210CNV Gain21882294


    Human Gene Mutation Database (HGMD): REL
    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing REL:
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing REL
    DNA2.0 Custom Variant and Variant Library Synthesis for REL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164910    OMIM disorders: --

    20/37 diseases for REL (see all 37):    About MalaCards
    nodular lymphocyte predominant hodgkin lymphoma    histoplasmosis    primary mediastinal large b-cell lymphoma    mediastinitis
    sclerosing cholangitis    primary sclerosing cholangitis    diffuse large b-cell lymphoma    cholangitis
    b-cell lymphomas    keratitis    adult t-cell leukemia    t-cell leukemia
    human t-cell leukemia virus type 1    hodgkin's lymphoma    psoriatic arthritis    dermatitis
    celiac disease    atopic dermatitis    ulcerative colitis    crohn's disease

    2 diseases from the University of Copenhagen DISEASES database for REL:
    Lymphoma     Leukemia

    REL for disorders           About GeneDecksing

    10/24 Novoseek inferred disease relationships for REL gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 55.9 4 7935451 (1), 9247567 (1), 8510222 (1)
    reticuloendotheliosis 54.8 2 1848011 (1), 15870177 (1)
    lymphoma b-cell 45.1 18 17072339 (4), 16027730 (2), 17197926 (2), 15644776 (2) (see all 7)
    htlv-i infections 37.3 1 8627746 (1)
    response acute phase 36 1 14530385 (1)
    necrosis 33.2 5 8152812 (1), 9435232 (1), 8621542 (1), 10823840 (1) (see all 5)
    hodgkin disease 26.5 11 15644776 (4), 14755244 (1), 18245482 (1), 15870177 (1) (see all 5)
    inflammation 26.5 3 15110174 (1), 12857966 (1), 19347041 (1)
    tumors 19.7 19 17138822 (3), 12897145 (2), 9435232 (1), 10602468 (1) (see all 16)
    immunodeficiency 19 4 1493333 (1), 8394446 (1), 15917220 (1), 1741161 (1)

    Genetic Association Database (GAD): REL
    Human Genome Epidemiology (HuGE) Navigator: REL (28 documents)
    Tumor Gene Database (TGDB): REL

    Export disorders for REL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REL gene, integrated from 9 sources (see all 322):
    (articles sorted by number of sources associating them with REL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor. (PubMed id 8152812)1, 2, 9 Beg A.A. and Baldwin A.S. Jr. (1994)
    2. Genome-wide meta-analysis of psoriatic arthritis ident ifies susceptibility locus at REL. (PubMed id 22170493)1, 4 Ellinghaus E....Franke A. (2012)
    3. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    4. Genome-wide association study meta-analysis identifie s seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (2010)
    5. A genome-wide association study identifies new psoria sis susceptibility loci and an interaction between HLA-C and ERAP1. (PubMed id 20953190)1, 4  ....Trembath R.C. (2010)
    6. Genome-wide association identifies multiple ulcerativ e colitis susceptibility loci. (PubMed id 20228799)1, 4 McGovern D.P....Weersma R.K. (2010)
    7. Association between anti-tumour necrosis factor treat ment response and genetic variants within the TLR and NF{kappa}B signalling pat hways. (PubMed id 20448286)1, 4 Potter C....Wilson A.G. (2010)
    8. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). (PubMed id 21037568)1, 4 Enciso-Mora V....Houlston R.S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5966 HGNC: 9954 AceView: REL Ensembl:ENSG00000162924 euGenes: HUgn5966
    ECgene: REL Kegg: 5966 H-InvDB: REL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for REL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for REL gene:
    Search GeneIP for patents involving REL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of REL
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of REL
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for REL (c-Rel)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays for REL (c-Rel)  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for REL   OriGene RNAi products in human, mouse, rat for REL  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for REL  
     OriGene qSTAR qPCR primer pairs in human, mouse for REL   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for REL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for REL   OriGene Custom Protein Services for REL  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat REL
     QIAGEN SeqTarget long-range PCR primers for resequencing REL
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REL
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REL
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REL
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REL
     GenScript Custom Purified and Recombinant Proteins Services for REL GenScript cDNA clones with any tag delivered in your preferred vector for REL
     GenScript Custom Assay Services for REL GenScript Custom Superior Antibodies Services for REL
     GenScript Custom overexpressing Cell Line Services for REL CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for REL 

     Regulatory tfbs in REL promoter
     Search Chromatin IP Primers for REL
     RT2 qPCR Primer Assay in human, mouse, rat REL
     GNC Network for REL
     SABiosciences PCR Arrays including human, mouse, rat REL
     Search Tocris compounds for REL
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for REL
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     REL antibodies
     REL proteins
     Antibodies for REL
     See all of Abcam's Antibodies, Kits and Proteins for REL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for REL
     Antibodies for REL
     ELISAs for REL
     CLIAs for REL
     Search LifeMap BioReagents cell lines for REL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REL
     SwitchGear 3'UTR luciferase reporter plasmids for REL
     SwitchGear Promoter luciferase reporter plasmids for REL
     ThermoFisher Antibody for REL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REL
     inGenious Targeting Laboratory - Custom generated mouse model solutions for REL
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for REL
    Customized:
     lentivirus for stable overexpression of REL
     lentivirus expression plasmids for stable overexpression of REL
     adenovirus for overexpression of REL
     LSBio Antibodies in human, mouse, rat for REL
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      REL gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4