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Aliases &
Descriptions
for REL
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| C-Rel 2 | | I-Rel 1 | | c-Rel 1 |
| | | Descriptions |
|---|
| C-Rel protein 3 | | C-Rel proto-oncogene protein 2 | | oncogene REL, avian reticuloendotheliosis 2 | | v-rel avian reticuloendotheliosis viral oncogene homolog 1, 2 | | v-rel reticuloendotheliosis viral oncogene homolog 2 | | v-rel reticuloendotheliosis viral oncogene homolog (avian) 2 |
|
| |
Search outside databases for aliases for REL genePrevious GC identifers: GC02P061237 GC02P061067 GC02P061083 |
Summaries
for REL(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for REL:
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which
also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These
proteins are related through a highly conserved N-terminal region termed the 'Rel
domain,' which is responsible for DNA binding, dimerization, nuclear localization, and
binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed
18037997]).[supplied by OMIM]
UniProtKB/Swiss-Prot: REL_HUMAN, Q04864Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a
pleiotropic transcription factor which is present in almost all cell types and is involved in many
biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis
and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like
domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers
bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct
preferences for different kappa-B sites that they can bind with distinguishable affinity and
specificity. Different dimer combinations act as transcriptional activators or repressors,
respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification
and subcellular compartmentalization as well as by interactions with other cofactors or
corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with
members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway,
I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators,
subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the
nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator |
Genomic Location
for REL
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the REL gene 
Entrez Gene cytogenetic band: 2p13-p12 Ensembl cytogenetic band: 2p16.1 HGNC cytogenetic band: 2p13-p12REL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P061020:
(about GC identifiers)
Start:
|
60,962,256 bp from pter |
End:
|
61,003,682 bp from pter |
Size:
|
41,427 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins
for REL
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: REL_HUMAN, Q04864 (See
protein sequence)Recommended Name: C-Rel proto-oncogene protein Size: 619 amino acids; 68520 Da
Subunit: Component of the NF-kappa-B p65-c-Rel complex. Component of the NF-kappa-B p50-c-Rel
complex. Component of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B
c-Rel-c-Rel complex (By similarity). Interacts with NKIRAS1. Interacts with NFKBIB (By
similarity). Interacts with NFKBIE
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q2PNZ7 Q6LDY0Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002899.1
ENSEMBL proteins: ENSP00000295025 ENSP00000377989
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
About this table
Antibodies for REL:
Assays for REL: | Protein
Domains/
Families
for REL(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q04864
ProtoNet protein and cluster: Q04864 3 Blocks protein families: IPB000451 NF-kappa-B/Rel/dorsal family IPB002909 Cell surface receptor IPT/TIG IPB011539 Rel homology
UniProtKB/Swiss-Prot: REL_HUMAN, Q04864Similarity: Contains 1 RHD (Rel-like) domain | Gene Function
for REL
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002908
 Applied Biosystems Silencer® siRNAs for REL
 Sigma-Aldrich siRNA for REL
Sigma-Aldrich shRNA Panels and shRNA for REL
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002908
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002908
untagged cDNA clones in CMV expression vector (see all 2): NM_002908
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_002908
UniProtKB/Swiss-Prot: REL_HUMAN, Q04864Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a
pleiotropic transcription factor which is present in almost all cell types and is involved in many
biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis
and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like
domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers
bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct
preferences for different kappa-B sites that they can bind with distinguishable affinity and
specificity. Different dimer combinations act as transcriptional activators or repressors,
respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification
and subcellular compartmentalization as well as by interactions with other cofactors or
corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with
members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway,
I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators,
subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the
nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activatorGenatlas biochemistry entry for REL:avian reticuloendotheliosis viral (v-rel) oncogene homolog,involved in lymphomagenesis (diffuse
large B cell lymphoma)15 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Rel):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for REL
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for REL (Your Favorite Gene powered by Ingenuity)
Gene Network CentralTM Interacting Genes and Proteins Network for REL
5/93 Interacting proteins for REL (Q048641, 2 ENSP000002950253) via UniProtKB, MINT, and/or STRING (see all 93
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade |
IEP | 12761501 |
About this table
|
Drugs & Compounds
for REL(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for REL |
 Compounds for REL available from Tocris Bioscience
10/12  Novoseek chemical compound relationships for REL gene (see all 12
)
About this table
|
Transcripts
for REL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002908
Sigma-Aldrich siRNA for REL
Sigma-Aldrich shRNA Panels and shRNA for REL
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_002908 REFSEQ mRNAs for REL gene: NM_002908.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002908
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002908
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002908
untagged cDNA clones in CMV expression vector (see all 2): NM_002908
Additional cDNA sequence: AK303926.1 BC051005.1 BC117191.1 BC143885.1 X75042.1 4 DOTS entries: DT.311516 DT.100009811 DT.95360644 DT.91984554 24/37 AceView cDNA sequences (see all 37
):AI910463 AI917588 BF446716 BX111941 BF115212 AA279919 NM_002908 N56815 BE217899 X75042 BM457679 AW206529 BF445023 AA827904 AA122307 AW206098 CD640399 BG431685 BC051005 AA279536 BU657110 AA741446 AI247359 AI760025
 highest scoring ESTs for REL:X75042 AA122307 AA279536 AA279919 AA827904 AW381823 BE935351 BE935362 BF844707 BG431685 Unigene Cluster for REL: V-rel reticuloendotheliosis viral oncogene homolog (avian) Hs.631886 [show with all ESTs]Unigene Representative Sequence: NM_002908
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000295025
ENST00000394479
|
Expression
for REL
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| REL expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for REL
1 / 2 / 3 4 probe-sets matching REL gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.631886
Expression variation in blood from EXPOLDB for REL |
Orthologs
for REL
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for REL gene from 5/9 species (see all 9
)
About this table Species with no ortholog for REL
ENSEMBL Gene Tree for REL | Paralogs
for REL(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for REL gene
- NFKB12 NFKB22 RELB2 RELA2
|
SNPs/Variants
for REL(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for REL (up to first 250kb)
|
Disorders & Mutations
for REL
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 164910
10/24 Novoseek disease relationships for REL gene (see all 24
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia t-cell |
56.67 |
4 |
7935451 (1), 9247567 (1), 8510222 (1) |
| reticuloendotheliosis |
56.08 |
2 |
1848011 (1), 15870177 (1) |
| lymphoma b-cell |
44.75 |
18 |
17072339 (4), 16027730 (2), 17197926 (2), 15644776 (2) (see all 7) |
| htlv-i infections |
37.95 |
1 |
8627746 (1) |
| response acute phase |
36.92 |
1 |
14530385 (1) |
| necrosis |
34.59 |
5 |
8152812 (1), 9435232 (1), 8621542 (1), 10823840 (1) (see all 5) |
| hodgkin disease |
27.74 |
11 |
15644776 (4), 14755244 (1), 18245482 (1), 15870177 (1) (see all 5) |
| inflammation |
25.19 |
3 |
15110174 (1), 12857966 (1), 19347041 (1) |
| tumors |
21.53 |
19 |
17138822 (3), 12897145 (2), 9435232 (1), 10602468 (1) (see all 16) |
| immunodeficiency |
20.16 |
4 |
1493333 (1), 8394446 (1), 15917220 (1), 1741161 (1) |
About this table
Human Gene Mutation Database: REL
Human Genome Epidemiology Navigator: REL (10 documents)
Tumor Gene Database: REL
|
Medical News
for REL(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for REL (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/269 PubMed articles for REL gene (see all 269
):- Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor. (PubMed id 8152812)1, 3, 4 Beg A.A. and Baldwin A.S. (1994)
- Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. (PubMed id 15024091)3, 4 Chen Y.... Ghosh G. (2004)
- A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. (PubMed id 9315679)3, 4 Li Z. and Nabel G.J. (1997)
- A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene. (PubMed id 1740106)3, 4 Hansen S.K....Blasi F. (1992)
- I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. (PubMed id 1577270)2, 3 Ruben S.M....Rosen C.A. (1992)
- A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon. (PubMed id 2666912)3, 4 Brownell E.... Rice N.R. (1989)
- Genetic characterization of human c-rel sequences. (PubMed id 3016517)3, 4 Brownell E.... Rice N.R. (1985)
- Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation. (PubMed id 8621542)1, 3 Meyer C.F....Tan T.H. (1996)
- Deficient translocation of c-Rel is associated with impaired Th1 cytokine production in T cells from atopic dermatitis patients. (PubMed id 15660915)1, 3 Dieckhoff K....Jung T. (2005)
- Unraveling androgen receptor interactomes by an array-based method: discovery of proto-oncoprotein c-Rel as a negative regulator of androgen receptor. (PubMed id 17011549)1, 3 Mukhopadhyay N.K....Liu B.C. (2006)
|
Search for REL
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing REL
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing REL
(According to HUGE)
About This Section
| -- |
Specialized Databases showing REL(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for REL(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for REL:
 | |
 | | | | |
 |
 |  |  | |
 | Antibodies & Assays for REL (C-Rel) |
| | | | | Tocris compounds for REL |
|
 |
 | | | | Antibodies for REL |
|
|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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