Free for academic non-profit institutions. Other users need a Commercial license

Aliases for REG4 Gene

Aliases for REG4 Gene

  • Regenerating Family Member 4 2 3 5
  • Gastrointestinal Secretory Protein 2 3 4
  • Regenerating Islet-Derived Family, Member 4 2 3
  • Regenerating Islet-Derived Protein IV 3 4
  • Regenerating Gene Type IV 2 3
  • REG-Like Protein 3 4
  • Reg IV 3 4
  • REG-4 3 4
  • GISP 3 4
  • RELP 3 4
  • Regenerating Islet-Derived Protein 4 3
  • REG-IV 3

External Ids for REG4 Gene

Previous GeneCards Identifiers for REG4 Gene

  • GC01M119483
  • GC01M119683
  • GC01M120048
  • GC01M120138
  • GC01M120336
  • GC01M118195

Summaries for REG4 Gene

GeneCards Summary for REG4 Gene

REG4 (Regenerating Family Member 4) is a Protein Coding gene. Diseases associated with REG4 include Ulcerative Colitis and Colorectal Adenoma. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is REG3A.

UniProtKB/Swiss-Prot for REG4 Gene

  • Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.

Gene Wiki entry for REG4 Gene

Additional gene information for REG4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REG4 Gene

Genomics for REG4 Gene

Regulatory Elements for REG4 Gene

Enhancers for REG4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H119782 1.4 Ensembl ENCODE dbSUPER 17.2 +26.0 25990 6.9 PKNOX1 FOXA2 RAD21 RFX5 RARA YY1 ZNF766 ZNF366 FOS CEBPB PHGDH WARS2 REG4 HMGCS2 ADAM30 LOC101929147
GH01H119765 1.4 Ensembl ENCODE dbSUPER 10.1 +43.9 43854 4.5 ELF3 FOXA2 NFIB ARID4B ZNF195 THRB RAD21 RARA YY1 SCRT2 HSD3BP5 LOC101929147 ADAM30 REG4 ZNF697 HMGCS2 GC01P119741 PIR35373
GH01H119857 1.2 Ensembl ENCODE 11.6 -47.5 -47481 2.7 HDAC1 PKNOX1 ATF1 ZBTB40 TCF12 ZNF766 CBX5 FOS ATF7 ETV6 LOC101929147 ADAM30 REG4 HMGCS2 WARS2 ZNF697 PIR62590 PFN1P9
GH01H119789 1 ENCODE dbSUPER 11.8 +20.8 20779 2.4 ELF3 SOX13 TFAP4 FOXA2 TAF1 MAX RAD21 RARA YY1 GATA3 HMGCS2 REG4 ADAM30
GH01H119870 1.1 Ensembl ENCODE 10.6 -59.5 -59524 0.6 CTCF RB1 CEBPG RAD21 YY1 TEAD3 IRF9 CC2D1A CTBP1 ZBTB48 ADAM30 REG4 PIR62590 NOTCH2P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around REG4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for REG4 Gene

Genomic Locations for REG4 Gene
17,643 bases
Minus strand

Genomic View for REG4 Gene

Genes around REG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REG4 Gene

Proteins for REG4 Gene

  • Protein details for REG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regenerating islet-derived protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8NER6
    • Q8NER7

    Protein attributes for REG4 Gene

    158 amino acids
    Molecular mass:
    18230 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAM95599.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for REG4 Gene

    Alternative splice isoforms for REG4 Gene


neXtProt entry for REG4 Gene

Post-translational modifications for REG4 Gene

  • Glycosylation at isoforms=250
  • Modification sites at PhosphoSitePlus

Other Protein References for REG4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for REG4 (REG4)
  • Abcam antibodies for REG4
  • Santa Cruz Biotechnology (SCBT) Antibodies for REG4

Assay Products

  • Cloud-Clone Corp. Assay Kits for REG4
  • Abcam assays for REG4

No data available for DME Specific Peptides for REG4 Gene

Domains & Families for REG4 Gene

Gene Families for REG4 Gene

Suggested Antigen Peptide Sequences for REG4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with REG4: view

No data available for UniProtKB/Swiss-Prot for REG4 Gene

Function for REG4 Gene

Molecular function for REG4 Gene

UniProtKB/Swiss-Prot Function:
Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.
UniProtKB/Swiss-Prot Induction:
Up-regulated by mucosal injury from active Crohns disease or ulcerative colitis. Up-regulated in colorectal tumors. Up-regulated in epithelial cells at regenerating margins of peptic ulcers in the stomach and duodenum.

Gene Ontology (GO) - Molecular Function for REG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 NOT calcium ion binding IDA 20692269
GO:0008201 heparin binding IDA 20692269
GO:0030246 carbohydrate binding IEA --
GO:2001065 mannan binding IDA 20692269
genes like me logo Genes that share ontologies with REG4: view
genes like me logo Genes that share phenotypes with REG4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REG4 Gene

Localization for REG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REG4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REG4 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for REG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA 12819006
genes like me logo Genes that share ontologies with REG4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for REG4 Gene

Pathways & Interactions for REG4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REG4 Gene


No data available for Pathways by source and SIGNOR curated interactions for REG4 Gene

Drugs & Compounds for REG4 Gene

(1) Drugs for REG4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with REG4: view

Transcripts for REG4 Gene

Unigene Clusters for REG4 Gene

Regenerating islet-derived family, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for REG4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: -

Relevant External Links for REG4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for REG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REG4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x32.8), Pancreas (x13.5), and Colon - Transverse (x4.6).

Protein differential expression in normal tissues from HIPED for REG4 Gene

This gene is overexpressed in Fetal gut (52.2), Colon (7.1), and Pancreatic juice (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for REG4 Gene

Protein tissue co-expression partners for REG4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of REG4 Gene:


SOURCE GeneReport for Unigene cluster for REG4 Gene:


mRNA Expression by UniProt/SwissProt for REG4 Gene:

Tissue specificity: Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in normal colon. Preferentially expressed in mucinous tumors and in some cases neuro-endocrine tumors. Expressed in mucus-secreting cells and enterocyte-like cells. In small intestine expressed at the basal perinuclear zone of goblet cells.

Evidence on tissue expression from TISSUES for REG4 Gene

  • Intestine(4.9)
  • Stomach(4.2)
  • Pancreas(2.5)
genes like me logo Genes that share expression patterns with REG4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for REG4 Gene

Orthologs for REG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for REG4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia REG4 33 34
  • 99.79 (n)
(Canis familiaris)
Mammalia LOC475818 33
  • 83.12 (n)
-- 34
  • 76 (a)
-- 34
  • 75 (a)
-- 34
  • 63 (a)
(Bos Taurus)
Mammalia REG4 33 34
  • 82.49 (n)
(Rattus norvegicus)
Mammalia Reg4 33
  • 77.71 (n)
(Mus musculus)
Mammalia Reg4 33 16 34
  • 77.35 (n)
(Monodelphis domestica)
Mammalia REG4 34
  • 67 (a)
(Gallus gallus)
Aves REG4 33
  • 51.75 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485485 33
  • 52.11 (n)
Species where no ortholog for REG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for REG4 Gene

Gene Tree for REG4 (if available)
Gene Tree for REG4 (if available)

Paralogs for REG4 Gene

Paralogs for REG4 Gene

(9) SIMAP similar genes for REG4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with REG4: view

Variants for REG4 Gene

Sequence variations from dbSNP and Humsavar for REG4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000000493 -- 119,800,862(+) TTTGG(A/G)GGTTT intron-variant
rs1000019976 -- 119,804,673(+) ACTAC(C/T)AGTAC intron-variant
rs1000079425 -- 119,799,186(+) GACCC(-/CA)CACCT intron-variant
rs1000117501 -- 119,801,930(+) ATGAG(A/G)TAAAA intron-variant, downstream-variant-500B
rs1000161888 -- 119,797,781(+) GTCAC(A/G)ACCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REG4 Gene

Variant ID Type Subtype PubMed ID
nsv831226 CNV gain+loss 17160897
nsv831215 CNV gain 17160897
nsv524681 CNV gain 19592680
nsv428201 CNV gain 18775914

Variation tolerance for REG4 Gene

Residual Variation Intolerance Score: 81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REG4 Gene

Disorders for REG4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for REG4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ulcerative colitis
  • left-sided ulcerative colitis
colorectal adenoma
  • adenoma of large intestine
- elite association - COSMIC cancer census association via MalaCards
Search REG4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for REG4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with REG4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REG4 Gene

Publications for REG4 Gene

  1. Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. (PMID: 12455032) Violette S … Lesuffleur T (International journal of cancer 2003) 2 3 4 22 60
  2. RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa. (PMID: 12819006) Kämäräinen M … Andersson LC (The American journal of pathology 2003) 3 4 22 60
  3. Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. (PMID: 11311942) Hartupee JC … Dieckgraefe BK (Biochimica et biophysica acta 2001) 2 3 4 60
  4. Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites. (PMID: 20692269) Ho MR … Chen C (Journal of molecular biology 2010) 3 4 60
  5. The role of Reg IV gene and its encoding product in gastric carcinogenesis. (PMID: 19740514) Zheng HC … Takano Y (Human pathology 2010) 3 22 60

Products for REG4 Gene

Sources for REG4 Gene

Loading form....