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Aliases for REG3G Gene

Aliases for REG3G Gene

  • Regenerating Islet-Derived 3 Gamma 2 3
  • PAP1B 3 4 6
  • Regenerating Islet-Derived Protein III-Gamma 3 4
  • Pancreatitis-Associated Protein 1B 3 4
  • Pancreatitis-Associated Protein IB 3 4
  • Reg III-Gamma 3 4
  • REG-3-Gamma 3 4
  • REG III 3 4
  • PAP IB 3 4
  • PAP-1B 3 4
  • Regenerating Islet-Derived Protein 3-Gamma 3
  • Regenerating Gene III 3
  • LPPM429 3
  • REG-III 3
  • UNQ429 3
  • PAPIB 3

External Ids for REG3G Gene

Previous GeneCards Identifiers for REG3G Gene

  • GC02P079165
  • GC02P079106

Summaries for REG3G Gene

Entrez Gene Summary for REG3G Gene

  • This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]

GeneCards Summary for REG3G Gene

REG3G (Regenerating Islet-Derived 3 Gamma) is a Protein Coding gene. Diseases associated with REG3G include pancreatitis. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is REG1B.

UniProtKB/Swiss-Prot for REG3G Gene

  • Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.

Gene Wiki entry for REG3G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REG3G Gene

Genomics for REG3G Gene

Regulatory Elements for REG3G Gene

Genomic Location for REG3G Gene

Start:
79,025,686 bp from pter
End:
79,028,505 bp from pter
Size:
2,820 bases
Orientation:
Plus strand

Genomic View for REG3G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REG3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REG3G Gene

Proteins for REG3G Gene

  • Protein details for REG3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW15-REG3G_HUMAN
    Recommended name:
    Regenerating islet-derived protein 3-gamma
    Protein Accession:
    Q6UW15
    Secondary Accessions:
    • A8K980
    • D6W5J6
    • Q3SYE4
    • Q3SYE6
    • Q6FH18

    Protein attributes for REG3G Gene

    Size:
    175 amino acids
    Molecular mass:
    19330 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for REG3G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REG3G Gene

Proteomics data for REG3G Gene at MOPED

Post-translational modifications for REG3G Gene

  • Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.

Other Protein References for REG3G Gene

No data available for DME Specific Peptides for REG3G Gene

Domains for REG3G Gene

Suggested Antigen Peptide Sequences for REG3G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UW15

UniProtKB/Swiss-Prot:

REG3G_HUMAN :
  • Q6UW15
Domain:
  • The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with REG3G: view

No data available for Gene Families for REG3G Gene

Function for REG3G Gene

Molecular function for REG3G Gene

UniProtKB/Swiss-Prot Function: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.

Gene Ontology (GO) - Molecular Function for REG3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with REG3G: view

Phenotypes for REG3G Gene

genes like me logo Genes that share phenotypes with REG3G: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REG3G

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for REG3G Gene

Localization for REG3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for REG3G Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REG3G Gene COMPARTMENTS Subcellular localization image for REG3G gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for REG3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with REG3G: view

Pathways for REG3G Gene

SuperPathways for REG3G Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cardiotoxicity in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Interacting Proteins for REG3G Gene

Gene Ontology (GO) - Biological Process for REG3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002755 MyD88-dependent toll-like receptor signaling pathway ISS --
GO:0006953 acute-phase response IEA --
GO:0010838 positive regulation of keratinocyte proliferation ISS --
GO:0045617 negative regulation of keratinocyte differentiation ISS --
GO:0050830 defense response to Gram-positive bacterium ISS --
genes like me logo Genes that share ontologies with REG3G: view

No data available for Pathways by source for REG3G Gene

Transcripts for REG3G Gene

Unigene Clusters for REG3G Gene

Regenerating islet-derived 3 gamma:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REG3G

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for REG3G
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REG3G Gene

No ASD Table

Relevant External Links for REG3G Gene

GeneLoc Exon Structure for
REG3G
ECgene alternative splicing isoforms for
REG3G

Expression for REG3G Gene

mRNA expression in normal human tissues for REG3G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REG3G Gene

This gene is overexpressed in Pancreas (49.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for REG3G Gene

SOURCE GeneReport for Unigene cluster for REG3G Gene Hs.447084

mRNA Expression by UniProt/SwissProt for REG3G Gene

Q6UW15-REG3G_HUMAN
Tissue specificity: Predominantly expressed in pancreas, where it may be restricted to exocrine pancreas. Moderate expression levels in testis and weak in heart, kidney and placenta.
genes like me logo Genes that share expressions with REG3G: view

In Situ Assay Products

Orthologs for REG3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for REG3G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REG3G 35
  • 98.48 (n)
  • 96 (a)
REG3G 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTP 36
  • 70 (a)
ManyToMany
REG3A 35
  • 81.71 (n)
  • 70.29 (a)
REG3G 36
  • 65 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia REG3A 35
  • 85.9 (n)
  • 77.14 (a)
REG3A 36
  • 77 (a)
ManyToMany
REG3A 36
  • 77 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Reg3a 16
Reg3a 36
  • 65 (a)
ManyToMany
Reg3b 36
  • 68 (a)
ManyToMany
Reg3d 36
  • 51 (a)
ManyToMany
Reg3g 35
  • 74.95 (n)
  • 65.32 (a)
Reg3g 36
  • 65 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Reg3g 35
  • 75.34 (n)
  • 66.47 (a)
chicken
(Gallus gallus)
Aves REG4 36
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for REG3G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for REG3G Gene

ENSEMBL:
Gene Tree for REG3G (if available)
TreeFam:
Gene Tree for REG3G (if available)

Paralogs for REG3G Gene

Paralogs for REG3G Gene

Selected SIMAP similar genes for REG3G Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with REG3G: view

Variants for REG3G Gene

Sequence variations from dbSNP and Humsavar for REG3G Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs368506 -- 79,025,635(+) TTTGA(A/G)CCAAT upstream-variant-2KB
rs369221 -- 79,025,824(+) CACAT(A/G)ATACA intron-variant, utr-variant-5-prime
rs369967 -- 79,026,024(+) GTAGG(A/G)TATCT utr-variant-5-prime, intron-variant
rs374577 -- 79,028,462(+) ATGTC(C/T)TGAGA utr-variant-3-prime
rs383969 -- 79,028,300(+) AGCCT(C/G)AGCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for REG3G Gene

Variant ID Type Subtype PubMed ID
nsv522260 CNV Gain 19592680

Relevant External Links for REG3G Gene

HapMap Linkage Disequilibrium report
REG3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REG3G Gene

Disorders for REG3G Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for REG3G Gene including...

Search for REG3G Gene in MalaCards »
genes like me logo Genes that share disorders with REG3G: view

No data available for UniProtKB/Swiss-Prot for REG3G Gene

Publications for REG3G Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III. (PMID: 15556304) Nata K. … Okamoto H. (Gene 2004) 3 4
  5. PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication. (PMID: 15777617) Laurine E. … Verdier J.-M. (Biochim. Biophys. Acta 2005) 3 4

Products for REG3G Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cardiotoxicity in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate REG3G
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for REG3G
  • Block miRNA regulation of REG3G using miScript Target Protectors

Sources for REG3G Gene

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