REG3G Gene
protein-coding GIFtS: 43
GCID: GC02P079165
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|
regenerating islet-derived 3 gamma
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Aliases
for REG3G gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Regenerating Islet-Derived 3 Gamma1 2 | | PAP-1B2 3 | | PAP1B1 2 3 5 | | REG-3-Gamma1 | | LPPM4291 2 | | PAP IB2 3 | | UNQ4291 2 | | PAPIB2 | | Pancreatitis-Associated Protein 1B2 3 | | REG-III2 | | Pancreatitis-Associated Protein IB2 3 | | Regenerating Gene III2 | | Reg III-Gamma2 3 | | Regenerating Islet-Derived Protein 3-Gamma2 | | Regenerating Islet-Derived Protein III-Gamma2 3 | | |
Export aliases for REG3G gene to outside databasesPrevious GC identifers: GC02P079106 GC02P078988 |
Summaries
for REG3G gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for REG3G:
This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted,C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this geneis an antibacterial lectin with activity against Gram-positive bacteria. Alternative splicing results in multipletranscript variants encoding multiple isoforms. (provided by RefSeq, Jun 2012)
UniProtKB/Swiss-Prot: REG3G_HUMAN, Q6UW15Function: Might be a stress protein involved in the control of bacterial proliferation (By similarity)
Gene Wiki entry for REG3G
|
Genomic Views
for REG3G gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the REG3G gene promoter:
STAT5B STAT1 AML1a STAT4 STAT2 STAT3 STAT1beta STAT6 STAT5A STAT1alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for REG3G
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REG3G |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p12 Ensembl cytogenetic band: 2p12 HGNC cytogenetic band: 2p12REG3G Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P079165: view genomic region
(about GC identifiers)
Start:
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79,252,812 bp from pter |
End:
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79,255,631 bp from pter |
Size:
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2,820 bases |
Orientation:
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plus strand |
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Proteins
for REG3G gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: REG3G_HUMAN, Q6UW15 (See
protein sequence)Recommended Name: Regenerating islet-derived protein 3-gamma precursor Size: 175 amino acids; 19330 Da
Subcellular location: Secreted
Secondary accessions: A8K980 D6W5J6 Q3SYE4 Q3SYE6 Q6FH18Alternative splicing: 2 isoforms: Q6UW15-1 Q6UW15-2 Explore the universe of human proteins at neXtProt for REG3G: NX_Q6UW15
REG3G Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001008388.1 NP_001256969.1 NP_940850.1
ENSEMBL proteins: ENSP00000377475 ENSP00000272324 ENSP00000387105
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
REG3G for ontologies About GeneDecksing
REG3G Antibody Products:
Assay Products for REG3G: |
Protein
Domains /
Families
for REG3G gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
REG3G for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UW15ProtoNet protein and cluster: Q6UW15 1 Blocks protein family: IPB003990 Pancreatitis-associated protein signature
UniProtKB/Swiss-Prot: REG3G_HUMAN, Q6UW15Similarity: Contains 1 C-type lectin domain |
Function
for REG3G gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: REG3G_HUMAN, Q6UW15Function: Might be a stress protein involved in the control of bacterial proliferation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REG3G (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REG3G (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030246 | carbohydrate binding |
IEA | -- |
REG3G for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for REG3G:
|
Pathways & Interactions
for REG3G gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for REG3G
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006953 | acute-phase response |
IEA | -- |
REG3G for ontologies About GeneDecksing
|
Drugs & Compounds
for REG3G gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for REG3G
Search CenterWatch for drugs/clinical trials and news about REG3G
|
Transcripts
for REG3G gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for REG3G gene (3 alternative transcripts): NM_001008387.2 NM_001270040.1 NM_198448.3 Unigene Cluster for REG3G: Regenerating islet-derived 3 gamma Hs.447084 [show with all ESTs]Unigene Representative Sequence: NM_0010083875 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000393897(uc002snw.3) ENST00000272324(uc002snx.3 uc010ffu.3)
ENST00000409471 ENST00000498312 ENST00000490944
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REG3G (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REG3G (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): REG3G (NM_198448) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for REG3G | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REG3G |
Additional cDNA sequence: AB161037.1 AB161038.1 AK292595.1 AY359047.1 AY428734.1 BC103852.2 BC103853.1 BC103854.1 CR541938.1 4 DOTS entries: DT.75102223 DT.95264502 DT.95264503 DT.97855666 23 AceView cDNA sequences: BI792387 AB161038 AB161037 BM264504 CA442887 AI198647 AY359047 CR541938 BF056837 BM504810 AW002913 NM_198448 AW196366 AI025191 AA621263 AA634522 AA725500 AI621017 AA397543 AW962460 AA399061 BQ787979 AI027597
GeneLoc Exon Structure
|
Expression
for REG3G gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| REG3G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCTGCCCA
About this image
See REG3G Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for REG3G
SOURCE GeneReport for Unigene cluster: Hs.447084
UniProtKB/Swiss-Prot: REG3G_HUMAN, Q6UW15Tissue specificity: Expressed almost exclusively in the pancreas. Also expressed in testis. Not found in smallintestine
SABiosciences Expression via Pathway-Focused PCR Arrays including REG3G: | Inflammatory Response & Autoimmunity 384HT in human mouse rat | | Cardiotoxicity in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REG3G
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REG3G | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REG3G | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REG3G |
Orthologs
for REG3G gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for REG3G gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for REG3G (if available)
TreeFam Gene Tree for REG3G (if available) |
Paralogs
for REG3G gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for REG3G gene
- REG3A2 REG42 CLEC19A2 REG1B2 REG1A2
5 SIMAP similar genes for REG3G using alignment to 1 protein entry: REG3G_HUMAN:PAP REG3A REG1A REG1B REG4
REG3G for paralogs About GeneDecksing
|
Genomic Variants
for REG3G gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for REG3G (79252812 - 79255631 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for REG3G: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REG3G |
|
Disorders
/ Diseases
for REG3G gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
REG3G for disorders About GeneDecksing
OMIM gene information: 609933
OMIM disorders: --
2  diseases for REG3G: About MalaCardspancreatitis listeriosis
Export disorders for REG3G gene to outside databases
|
Publications
for REG3G gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for REG3G gene integrated from 9 sources:
(articles sorted by number of sources associating them with REG3G) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication. (PubMed id 15777617)1, 2 Laurine E.... Verdier J.-M. (2005)
- Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III. (PubMed id 15556304)1, 2 Nata K.... Okamoto H. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- Helicobacter pylori CagA triggers expression of the ba ctericidal lectin REG3g via gastric STAT3 activation. (PubMed id 22312430)1 Lee K.S....Menheniott T.R. (2012)
- Symbiotic bacteria direct expression of an intestinal bactericidal lectin. (PubMed id 16931762)1 Cash H.L....Hooper L.V. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for REG3G gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing REG3G gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing REG3G gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing REG3G gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for REG3G | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for REG3G gene:
Search GeneIP for patents involving REG3G
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for REG3G gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for REG3G | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REG3G | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REG3G | | | OriGene Protein Over-expression Lysate for REG3G | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for REG3G | | OriGene 3'-UTR Clone for REG3G | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REG3G | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REG3G | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for REG3G | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for REG3G | | OriGene Custom Protein Services for REG3G | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat REG3G | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REG3G | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REG3G | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REG3G | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REG3G | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REG3G |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REG3G |
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