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Aliases for REG3G Gene

Aliases for REG3G Gene

  • Regenerating Family Member 3 Gamma 2 3 5
  • Regenerating Islet-Derived Protein III-Gamma 3 4
  • Regenerating Islet-Derived 3 Gamma 2 3
  • Pancreatitis-Associated Protein 1B 3 4
  • Pancreatitis-Associated Protein IB 3 4
  • Reg III-Gamma 3 4
  • REG-3-Gamma 3 4
  • REG III 3 4
  • PAP IB 3 4
  • PAP-1B 3 4
  • PAP1B 3 4
  • Regenerating Islet-Derived Protein 3-Gamma 3
  • Regenerating Gene III 3
  • REG-III 3
  • LPPM429 3
  • UNQ429 3
  • PAPIB 3

External Ids for REG3G Gene

Previous GeneCards Identifiers for REG3G Gene

  • GC02P079165
  • GC02P079106

Summaries for REG3G Gene

Entrez Gene Summary for REG3G Gene

  • This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]

GeneCards Summary for REG3G Gene

REG3G (Regenerating Family Member 3 Gamma) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is REG3A.

UniProtKB/Swiss-Prot for REG3G Gene

  • Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.

Gene Wiki entry for REG3G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REG3G Gene

Genomics for REG3G Gene

Regulatory Elements for REG3G Gene

Enhancers for REG3G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G078967 0.8 ENCODE 0.2 -58.2 -58197 0.2 ELF3 FOXA2 DNMT3B THRB ZSCAN9 RARA THAP11 CEBPB MIER2 PPARG LOC105374822 REG3G
GH02G078977 0.8 ENCODE 0.2 -47.9 -47877 0.2 PKNOX1 TBL1XR1 WRNIP1 BACH1 BMI1 RELA CBX5 NFYB EED RCOR1 LOC105374822 REG3G
GH02G078979 0.6 ENCODE 0.2 -45.9 -45877 0.2 CTCF ZNF654 TRIM22 REST RAD21 SCRT2 SMC3 ZNF143 LOC105374822 REG3G
GH02G078941 0.6 FANTOM5 0.2 -83.9 -83855 0.4 GATA2 JUN ZNF512 FOS LOC105374822 REG3G
GH02G079084 0.2 ENCODE 0.2 +58.5 58464 0.2 REG1A REG1B REG3G
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around REG3G on UCSC Golden Path with GeneCards custom track

Genomic Location for REG3G Gene

Chromosome:
2
Start:
79,025,686 bp from pter
End:
79,028,505 bp from pter
Size:
2,820 bases
Orientation:
Plus strand

Genomic View for REG3G Gene

Genes around REG3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REG3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REG3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REG3G Gene

Proteins for REG3G Gene

  • Protein details for REG3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW15-REG3G_HUMAN
    Recommended name:
    Regenerating islet-derived protein 3-gamma
    Protein Accession:
    Q6UW15
    Secondary Accessions:
    • A8K980
    • D6W5J6
    • Q3SYE4
    • Q3SYE6
    • Q6FH18

    Protein attributes for REG3G Gene

    Size:
    175 amino acids
    Molecular mass:
    19330 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for REG3G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REG3G Gene

Post-translational modifications for REG3G Gene

  • Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.

Other Protein References for REG3G Gene

Antibody Products

  • Abcam antibodies for REG3G

No data available for DME Specific Peptides for REG3G Gene

Domains & Families for REG3G Gene

Gene Families for REG3G Gene

Suggested Antigen Peptide Sequences for REG3G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UW15

UniProtKB/Swiss-Prot:

REG3G_HUMAN :
  • The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
Domain:
  • The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
genes like me logo Genes that share domains with REG3G: view

Function for REG3G Gene

Molecular function for REG3G Gene

UniProtKB/Swiss-Prot Function:
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.

Gene Ontology (GO) - Molecular Function for REG3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
GO:0042834 peptidoglycan binding IDA 16931762
GO:0070492 oligosaccharide binding IDA 16931762
genes like me logo Genes that share ontologies with REG3G: view
genes like me logo Genes that share phenotypes with REG3G: view

Animal Models for REG3G Gene

MGI Knock Outs for REG3G:

Animal Model Products

  • Taconic Biosciences Mouse Models for REG3G

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for REG3G Gene

Localization for REG3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for REG3G Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REG3G gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for REG3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with REG3G: view

Pathways & Interactions for REG3G Gene

genes like me logo Genes that share pathways with REG3G: view

Pathways by source for REG3G Gene

3 Reactome pathways for REG3G Gene

Interacting Proteins for REG3G Gene

Gene Ontology (GO) - Biological Process for REG3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002755 MyD88-dependent toll-like receptor signaling pathway ISS --
GO:0006953 acute-phase response IEA --
GO:0006954 inflammatory response IEA --
GO:0010838 positive regulation of keratinocyte proliferation ISS --
GO:0019730 antimicrobial humoral response TAS --
genes like me logo Genes that share ontologies with REG3G: view

No data available for SIGNOR curated interactions for REG3G Gene

Drugs & Compounds for REG3G Gene

No Compound Related Data Available

Transcripts for REG3G Gene

Unigene Clusters for REG3G Gene

Regenerating islet-derived 3 gamma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for REG3G Gene

No ASD Table

Relevant External Links for REG3G Gene

GeneLoc Exon Structure for
REG3G
ECgene alternative splicing isoforms for
REG3G

Expression for REG3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for REG3G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REG3G Gene

This gene is overexpressed in Pancreas (x49.7).

Protein differential expression in normal tissues from HIPED for REG3G Gene

This gene is overexpressed in Pancreas (36.7) and Islet of Langerhans (32.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for REG3G Gene



Protein tissue co-expression partners for REG3G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of REG3G Gene:

REG3G

SOURCE GeneReport for Unigene cluster for REG3G Gene:

Hs.447084

mRNA Expression by UniProt/SwissProt for REG3G Gene:

Q6UW15-REG3G_HUMAN
Tissue specificity: Predominantly expressed in pancreas, where it may be restricted to exocrine pancreas. Moderate expression levels in testis and weak in heart, kidney and placenta.

Evidence on tissue expression from TISSUES for REG3G Gene

  • Pancreas(4.4)
  • Intestine(2)
genes like me logo Genes that share expression patterns with REG3G: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for REG3G Gene

Orthologs for REG3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for REG3G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REG3G 34 35
  • 98.48 (n)
dog
(Canis familiaris)
Mammalia REG3A 34 35 35
  • 85.9 (n)
cow
(Bos Taurus)
Mammalia REG3A 34
  • 81.71 (n)
PTP 35
  • 70 (a)
ManyToMany
REG3G 35
  • 65 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Reg3g 34
  • 75.34 (n)
mouse
(Mus musculus)
Mammalia Reg3g 34 16 35
  • 74.95 (n)
Reg3b 35
  • 68 (a)
ManyToMany
Reg3a 35
  • 65 (a)
ManyToMany
Reg3d 35
  • 51 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
chicken
(Gallus gallus)
Aves REG4 35
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 35 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
Species where no ortholog for REG3G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for REG3G Gene

ENSEMBL:
Gene Tree for REG3G (if available)
TreeFam:
Gene Tree for REG3G (if available)

Paralogs for REG3G Gene

Paralogs for REG3G Gene

(5) SIMAP similar genes for REG3G Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with REG3G: view

Variants for REG3G Gene

Sequence variations from dbSNP and Humsavar for REG3G Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000037572 -- 79,024,310(+) AAATT(G/T)CCAGC upstream-variant-2KB
rs1000494503 -- 79,027,916(+) TGGGA(A/G)CCTGT reference, missense
rs1001059705 -- 79,024,507(+) GTTAA(C/T)AAAAG upstream-variant-2KB
rs1001676543 -- 79,025,222(+) TTTCT(A/G)TTGTT upstream-variant-2KB
rs1002127277 -- 79,025,492(+) AGAAG(A/G)TATCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for REG3G Gene

Variant ID Type Subtype PubMed ID
esv3584761 CNV loss 24956385
esv3892770 CNV gain 25118596
nsv522260 CNV gain 19592680

Variation tolerance for REG3G Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REG3G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
REG3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REG3G Gene

Disorders for REG3G Gene

Relevant External Links for REG3G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REG3G

No disorders were found for REG3G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REG3G Gene

Publications for REG3G Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication. (PMID: 15777617) Laurine E. … Verdier J.-M. (Biochim. Biophys. Acta 2005) 3 4 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for REG3G Gene

Sources for REG3G Gene

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