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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REG3A Gene

protein-coding   GIFtS: 55
GCID: GC02M079384

Regenerating Islet-Derived 3 Alpha

(Previous name: pancreatitis-associated protein)
(Previous symbol: PAP)
Microbiology & Infectious Diseases Congress
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Aliases
for REG3A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Regenerating Islet-Derived 3 Alpha1 2     INGAP2
PAP1 2 3 5     PAP-H2
Hepatointestinal Pancreatic Protein2 3     PBCGF2
Human Proislet Peptide2 3     REG-III2
Pancreatitis-Associated Protein 12 3     REG32
Reg III-Alpha2 3     hepatocarcinoma-intestine-pancreas2
Regenerating Islet-Derived Protein III-Alpha2 3     Pancreatic Beta Cell Growth Factor2
HIP2 3     PAP Homologous Protein2
HIP/PAP2 3     Proliferation-Inducing Protein 342
PAP12 3     Proliferation-Inducing Protein 422
REG-3-alpha2 3     Regenerating Islet-Derived Protein 3-Alpha2
Pancreatitis-Associated Protein1     

External Ids:    HGNC: 86011   Entrez Gene: 50682   Ensembl: ENSG000001720167   OMIM: 1678055   UniProtKB: Q061413   

Export aliases for REG3A gene to outside databases

Previous GC identifers: GC02M079296 GC02M079119


Summaries
for REG3A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for REG3A Gene:
This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It
has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during
pancreatic inflammation and liver carcinogenesis. Alternate splicing results in multiple transcript variants that
encode the same protein.(provided by RefSeq, Dec 2010)

GeneCards Summary for REG3A Gene: 
REG3A (regenerating islet-derived 3 alpha) is a protein-coding gene. Diseases associated with REG3A include pancreatitis, and digestive diseases. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is REG4.

UniProtKB/Swiss-Prot: REG3A_HUMAN, Q06141
Function: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial
killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte
proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway

Gene Wiki entry for REG3A Gene


Genomic Views
for REG3A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REG3A gene promoter:
         FOXJ2 (long isoform)   STAT3   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: REG3A promoter sequence
   Search SABiosciences Chromatin IP Primers for REG3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REG3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p12   HGNC cytogenetic band: 2p12

REG3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REG3A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M079384:  view genomic region     (about GC identifiers)

Start:
 79,384,132 bp from pter      End:
 79,386,880 bp from pter
Size:
 2,749 bases      Orientation:
 minus strand

Proteins
for REG3A gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: REG3A_HUMAN, Q06141 (See protein sequence)
Recommended Name: Regenerating islet-derived protein 3-alpha precursor  
Size: 175 amino acids; 19395 Da
Subunit: Interacts with EXTL3
Subcellular location: Secreted. Note=Found in the apical region of pancreatic acinar cells
2 PDB 3D structures from and Proteopedia for REG3A:
1UV0 (3D)        2GO0 (3D)    

Explore the universe of human proteins at neXtProt for REG3A: NX_Q06141

Explore proteomics data for REG3A at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan
    binding and antibacterial activity
  • View neXtProt modification sites for NX_Q06141

    • REG3A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    REG3A Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_002571.1  NP_620354.1  NP_620355.1  

    ENSEMBL proteins: 
     ENSP00000386630   ENSP00000304311   ENSP00000377456  

    Human Recombinant Protein Products for REG3A: 
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    Novus Biologicals REG3A Proteins
    Novus Biologicals REG3A Lysates
    Sino Biological Recombinant Protein for REG3A
    Sino Biological Cell Lysate for REG3A 
    ProSpec Recombinant Protein for REG3A
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8997243
    GO:0005737cytoplasm TAS8997243

    REG3A for ontologies           About GeneDecksing



    REG3A Antibody Products: 
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    Abcam antibodies for REG3A
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    ThermoFisher Antibody for REG3A
    LSBio Antibodies in human, mouse, rat for REG3A 

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    Browse ELISAs at Cloud-Clone Corp. 
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    Protein Domains /
    Families
    for REG3A gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 4 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q06141

    ProtoNet protein and cluster: Q06141

    1 Blocks protein domain: IPB003990 Pancreatitis-associated protein signature

    UniProtKB/Swiss-Prot: REG3A_HUMAN, Q06141
    Domain: The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient
    bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity
    Similarity: Contains 1 C-type lectin domain


    REG3A for domains           About GeneDecksing


    Function
    for REG3A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REG3A_HUMAN, Q06141
    Function: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial
    killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte
    proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway
    Induction: Appears in pancreatic juice after induction of pancreatic inflammation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding IEA--
         
    REG3A for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Reg3b):
     homeostasis/metabolism 

    REG3A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Reg3btm1Lex for REG3A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for REG3A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for REG3A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REG3A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REG3A 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: REG3A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for REG3A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REG3A

    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for REG3A
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                         Customized lentivirus expression plasmids for stable overexpression of REG3A 

    Cell Line
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    Search LifeMap BioReagents cell lines for REG3A
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG3A


    Pathways & Interactions
    for REG3A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for REG3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/19 Interacting proteins for REG3A (Q061413 ENSP000003043114) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    ANXA3P124293, ENSP000002649084I2D: score=1 STRING: ENSP00000264908
    REG1AP054513, ENSP000002337354I2D: score=1 STRING: ENSP00000233735
    SDC2P347413, ENSP000003070464I2D: score=2 STRING: ENSP00000307046
    TRHDEQ9UKU63, ENSP000002611804I2D: score=1 STRING: ENSP00000261180
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006953acute-phase response IEA--
    GO:0007157heterophilic cell-cell adhesion TAS8997243
    GO:0007275multicellular organismal development TAS8997243
    GO:0008283cell proliferation TAS8997243
    GO:0010838positive regulation of keratinocyte proliferation ISS--

    REG3A for ontologies           About GeneDecksing



    Drugs & Compounds
    for REG3A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    REG3A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REG3A

    7 Novoseek inferred chemical compound relationships for REG3A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trypsinogen 68.5 3 10325788 (1), 16182665 (1), 15850341 (1)
    probucol 41.4 1 14562608 (1)
    nicotinamide 39.1 1 17065390 (1)
    glucose 14 12 19723102 (1)
    streptozotocin 11.3 2 15133752 (1), 14562608 (1)
    prostacyclin 8.9 1 15979846 (1)
    thymidine 0 2 9151782 (1), 9849975 (1)

    Search CenterWatch for drugs/clinical trials and news about REG3A

    Transcripts
    for REG3A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for REG3A gene (3 alternative transcripts): 
    NM_002580.2  NM_138937.2  NM_138938.2  

    Unigene Cluster for REG3A:

    Regenerating islet-derived 3 alpha
    Hs.567312  [show with all ESTs]
    Unigene Representative Sequence: NM_138938
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409839(uc002soe.2 uc002sof.2) ENST00000305165 ENST00000490901
    ENST00000464746 ENST00000393878(uc002sod.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate REG3A
    SwitchGear 3'UTR luciferase reporter plasmid: REG3A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for REG3A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REG3A
    Clone
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    OriGene ORF clones in mouse, rat for REG3A
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    GenScript: all cDNA clones in your preferred vector (see all 3): REG3A (NM_002580)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REG3A
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REG3A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REG3A

    Additional mRNA sequence: 

    AK291973.1 AY544128.1 AY544130.1 BC036776.1 D13510.1 M84337.1 S51768.1 X68641.1 

    7 DOTS entries:

    DT.97855666  DT.95246610  DT.120944265  DT.100748110  DT.97855667  DT.95164560  DT.97822561 

    24/168 AceView cDNA sequences (see all 168):

    BM768702 BM769224 BM830351 BM830699 BM769049 BU074682 BQ083534 BQ778218 
    BM770023 BM768574 BM770013 BM769893 BQ083397 BU790202 BM769699 BM768595 
    BM853940 BU074396 BM773468 BQ777112 BM826749 BI324977 X68641 BM831177 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for REG3A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
    SP1:              -           -                           
    SP2:                          -                           
    SP3:              -                                       


    ECgene alternative splicing isoforms for REG3A

    Expression
    for REG3A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REG3A expression in normal human tissues (normalized intensities)      REG3A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGAGAAAT
    REG3A Expression
    About this image


    REG3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Pancreatic Islet   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine   
     
     Stomach (Gastrointestinal Tract)
             stomach cardiac   
     
     Lower Urinary Tract (Urinary System)
             bladder   
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns

    See REG3A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REG3A

    SOURCE GeneReport for Unigene cluster: Hs.567312

    UniProtKB/Swiss-Prot: REG3A_HUMAN, Q06141
    Tissue specificity: Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level).
    Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the
    acute phase of pancreatitis and in some patients with chronic pancreatitis

        SABiosciences Expression via Pathway-Focused PCR Array including REG3A: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG3A

    Orthologs
    for REG3A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for REG3A gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Reg3b1 , 5 regenerating islet-derived 3 beta1, 5 75.1(n)1
    69.54(a)1    		   6 (34.76 cM)5
    184891  NM_011036.11  NP_035166.11 
     783708855 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 10)    		 Uncharacterized protein
    (see all 10)    		 31(a)
    29(a)
    (see all 10)    		 many ↔ many
    many ↔ many
    (see all 10)    		 GL343442.1(335200-340404)
    GL343442.1(418755-426258)
    zebrafish
    (Danio rerio)    		 Actinopterygii REG1A6
    si:dkey-9i23.46
    (see all 4)    		 si:dkey-9i23.4
    (see all 4)    		 26(a)
    16(a)
    (see all 4)    		 1 ↔ many
    possible ortholog
    (see all 4)    		 1(9070895-9076445)
    1(45223135-45225533)
    worm
    (Caenorhabditis elegans)    		 Secernentea clec-1616
    clec-866
    (see all 3)    		 Protein CLEC-86
    (see all 3)    		 4(a)
    20(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 III(9603026-9608688)
    X(7139901-7140564)


    ENSEMBL Gene Tree for REG3A (if available)
    TreeFam Gene Tree for REG3A (if available)

    Paralogs
    for REG3A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for REG3A gene
    REG42  REG3G2  REG1B2  REG1A2  
    7 SIMAP similar genes for REG3A using alignment to 2 protein entries:     REG3A_HUMAN (see all proteins):
    PAP    REG3G    REG1A    REG1B    CSPG3 variant protein    NCAN
    REG4

    REG3A for paralogs           About GeneDecksing



    Genomic Variants
    for REG3A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/158 SNPs in REG3A are shown (see all 158)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs559314471,2
    		C,F--79248214(-) AAGAAA/GGGATG 3 -- ds50013Minor allele frequency- G:0.09WA NA EA 358
    rs1835515071,2
    		--79248253(+) CACTCA/GCTTGG 3 -- ds50010--------
    rs778543111,2
    		C,F--79248280(+) GAAGGT/CATTTC 3 -- ds50011Minor allele frequency- C:0.07EA 120
    rs1500436841,2
    		--79248394(+) CTAAGC/GACCAT 3 -- ds50010--------
    rs1885962661,2
    		--79248603(+) AGAAGA/CAAGAC 3 -- ds50010--------
    rs1928344311,2
    		--79248620(+) AGTTTC/TCTCCA 3 -- ds50010--------
    rs1453995971,2
    		--79248758(+) GACAGC/GGGGGA 3 -- ut310--------
    rs1857619731,2
    		--79248816(+) TTAAGC/TGAATA 3 -- ut310--------
    rs1875410591,2
    		--79248839(+) GTGAGC/TCCTCA 3 -- ut310--------
    rs1492229501,2
    		C--79248870(+) TGAGTG/TGCACA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for REG3A (79384132 - 79386880 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for REG3A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522260CNV Gain19592680

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    Disorders / Diseases
    for REG3A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 167805    OMIM disorders: --

    20/24 diseases for REG3A (see all 24):    About MalaCards
    pancreatitis    digestive diseases    pancreatic diseases    alcoholic pancreatitis
    acute pancreatitis    insulinoma    cystadenoma    pancreatic ductal adenocarcinoma
    cystic fibrosis    gastric adenocarcinoma    inflammatory bowel disease    duodenitis
    hepatocellular carcinoma    pituitary adenoma    pancreatic cancer    bipolar disorder
    alcoholism    crohn's disease    brain injury    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for REG3A:
    Pancreatitis

    REG3A for disorders           About GeneDecksing

    10/20 Novoseek inferred disease relationships for REG3A gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute pancreatitis 71.9 43 9026481 (9), 9382059 (5), 8119544 (3), 1469087 (3) (see all 12)
    pancreatitis 67.4 37 9026481 (3), 11396234 (3), 10325788 (2), 7890213 (2) (see all 15)
    pancreatic diseases 51.8 4 12120267 (3), 12757156 (1), 17497124 (1)
    chronic pancreatitis 50.1 5 12757156 (2), 10389686 (1), 19077460 (1), 1469087 (1)
    cystadenoma mucinous 46.8 1 12757156 (1)
    hepatocellular carcinoma 43 10 1325291 (2), 17192462 (1), 9520086 (1), 19051257 (1) (see all 7)
    pancreatic cancer 31.4 11 11396234 (4), 12757156 (3), 10389686 (2), 9520086 (1)
    colorectal carcinoma 30.4 19 19051257 (8)
    colorectal tumors 29.4 1 12455032 (1)
    inflammatory bowel diseases 27.9 3 15870231 (2)

    Genetic Association Database (GAD): REG3A
    Human Genome Epidemiology (HuGE) Navigator: REG3A (2 documents)

    Export disorders for REG3A gene to outside databases

    Publications
    for REG3A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REG3A gene, integrated from 9 sources (see all 118):
    (articles sorted by number of sources associating them with REG3A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene. (PubMed id 8188210)1, 2, 3, 9 Dusetti N.J....Iovanna J.L. (1994)
    2. A novel gene (HIP) activated in human primary liver cancer. (PubMed id 1325291)1, 2, 9 Lasserre C.... Brechot C. (1992)
    3. Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer. (PubMed id 8076648)1, 2, 9 Lasserre C.... Brechot C. (1994)
    4. Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases. (PubMed id 1469087)1, 2, 9 Orelle B.... Iovanna J.-L. (1992)
    5. Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP). (PubMed id 7679928)1, 2, 9 Itoh T. and Teraoka H. (1993)
    6. The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury. (PubMed id 22727489)1, 2 Lai Y....Gallo R.L. (2012)
    7. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    8. Molecular basis for peptidoglycan recognition by a ba ctericidal lectin. (PubMed id 20382864)1, 2 Lehotzky R.E....Hooper L.V. (2010)
    9. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. (PubMed id 19416921)1, 4 Scott L.J....Boehnke M. (2009)
    10. Proteolytic activation of human pancreatitis-associat ed protein is required for peptidoglycan binding and bacterial aggregation. (PubMed id 19254208)1, 2 Medveczky P....Sahin-TA^th M. (2009)

    External Searches for REG3A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing REG3A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5068 HGNC: 8601 AceView: PAP Ensembl:ENSG00000172016 euGenes: HUgn5068
    ECgene: REG3A H-InvDB: REG3A

    Other Databases showing REG3A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing REG3A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REG3A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for REG3A Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_256

    Intellectual Property
    for REG3A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for REG3A gene:
    Search GeneIP for patents involving REG3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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