REG3A Gene

Aliases
for REG3A gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC02M079296 GC02M079119

Summaries
for REG3A gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for REG3A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000002.11  NC_018913.2  NT_022184.16  

SwitchGear Promoter luciferase reporter plasmid: REG3A promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REG3A

REG3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M079384:  view genomic region     (about GC identifiers)

Proteins
for REG3A gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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3 PDB 3D structures from and Proteopedia for REG3A:

1UV0 (3D)        2GO0 (3D)        4MTH (3D)    

Explore the universe of human proteins at neXtProt for REG3A: NX_Q06141

Explore proteomics data for REG3A at MOPED

Post-translational modifications: 

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	antibodies-online peptides for REG3A

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Domains /
Families
for REG3A gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q06141

Find genes that share domains with REG3A           About GenesLikeMe

Function
for REG3A gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

(inferred from 1 allele) (MGI details for Reg3b)

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for REG3A

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG3A

Localization
for REG3A gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
nucleus	1
plasma membrane	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for REG3A gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

Drugs & Compounds
for REG3A gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for REG3A gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for REG3A gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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REG3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGAGAGAAAT

About this image

Pancreas (Endocrine System)    fully expand to see all 2 entries
Duct Cells Pancreatic Ducts
Islets of Langerhans
Epithelial Cells
Duct Cells Pancreatic Ducts
Testis (Reproductive System)
Sertoli cells Seminiferous Tubules
Neural Tube (Nervous System)
Spinal Ventral Columns

Primer Products:		OriGene qPCR primer pairs and template standards for REG3A OriGene qSTAR qPCR primer pairs in human, mouse for REG3A
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG3A

Orthologs
for REG3A gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for REG3A gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for REG3A gene

REG4²  REG3G²  REG1B²  REG1A²  

7 SIMAP similar genes for REG3A using alignment to 2 protein entries:     REG3A_HUMAN (see all proteins):

PAP    REG3G    REG1A    REG1B    CSPG3 variant protein    NCAN

REG4

Find genes that share paralogs with REG3A           About GenesLikeMe

Genomic Variants
for REG3A gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for REG3A (see all 158)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs559314471,2	C,F	--	79248214(-)	AAGAAA/GGGATG	3	--	ds5001		3		WA NA EA	358
rs1835515071,2		--	79248253(+)	CACTCA/GCTTGG	3	--	ds5001		0	--	--	--	--
rs778543111,2	C,F	--	79248280(+)	GAAGGT/CATTTC	3	--	ds5001		1		EA	120
rs1500436841,2		--	79248394(+)	CTAAGC/GACCAT	3	--	ds5001		0	--	--	--	--
rs1885962661,2		--	79248603(+)	AGAAGA/CAAGAC	3	--	ds5001		0	--	--	--	--
rs1928344311,2		--	79248620(+)	AGTTTC/TCTCCA	3	--	ds5001		0	--	--	--	--
rs1453995971,2		--	79248758(+)	GACAGC/GGGGGA	3	--	ut31		0	--	--	--	--
rs1857619731,2		--	79248816(+)	TTAAGC/TGAATA	3	--	ut31		0	--	--	--	--
rs1875410591,2		--	79248839(+)	GTGAGC/TCCTCA	3	--	ut31		0	--	--	--	--
rs1492229501,2	C	--	79248870(+)	TGAGTG/TGCACA	3	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for REG3A (79384132 - 79386880 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for REG3A:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv522260	CNV	Gain	19592680

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing REG3A

DNA2.0 Custom Variant and Variant Library Synthesis for REG3A

Disorders / Diseases
for REG3A gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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4 diseases for REG3A

Selected Novoseek inferred disease relationships for REG3A gene (see all 20)    About this table

Publications
for REG3A gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene. (PubMed id 8188210)^{1, 2, 3, 9} Dusetti N.J....Iovanna J.L. (Genomics 1994)
2. A novel gene (HIP) activated in human primary liver cancer. (PubMed id 1325291)^{1, 2, 9} Lasserre C.... Brechot C. (Cancer Res. 1992)
3. Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer. (PubMed id 8076648)^{1, 2, 9} Lasserre C.... Brechot C. (Eur. J. Biochem. 1994)
4. Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases. (PubMed id 1469087)^{1, 2, 9} Orelle B.... Iovanna J.-L. (J. Clin. Invest. 1992)
5. Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP). (PubMed id 7679928)^{1, 2, 9} Itoh T. and Teraoka H. (Biochim. Biophys. Acta 1993)
6. The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury. (PubMed id 22727489)^{1, 2} Lai Y.... Gallo R.L. (Immunity 2012)
7. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)^{1, 4} Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
8. Molecular basis for peptidoglycan recognition by a bactericidal lectin. (PubMed id 20382864)^{1, 2} Lehotzky R.E.... Hooper L.V. (Proc. Natl. Acad. Sci. U.S.A. 2010)
9. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. (PubMed id 19416921)^{1, 4} Scott L.J....Boehnke M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
10. Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation. (PubMed id 19254208)^{1, 2} Medveczky P.... Sahin-Toth M. (Biochem. J. 2009)

External Searches for REG3A gene

Genome Databases showing REG3A gene

Other Databases showing REG3A gene

Specialized Databases showing REG3A gene

Products
for REG3A gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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