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Aliases for REG3A Gene

Aliases for REG3A Gene

  • Regenerating Islet-Derived 3 Alpha 2 3
  • PAP 3 4 6
  • Regenerating Islet-Derived Protein III-Alpha 3 4
  • Hepatointestinal Pancreatic Protein 3 4
  • Pancreatitis-Associated Protein 1 3 4
  • Human Proislet Peptide 3 4
  • Reg III-Alpha 3 4
  • REG-3-Alpha 3 4
  • HIP/PAP 3 4
  • PAP1 3 4
  • HIP 3 4
  • Regenerating Islet-Derived Protein 3-Alpha 3
  • Pancreatic Beta Cell Growth Factor 3
  • Hepatocarcinoma-Intestine-Pancreas 3
  • Proliferation-Inducing Protein 34 3
  • Proliferation-Inducing Protein 42 3
  • Pancreatitis-Associated Protein 2
  • PAP Homologous Protein 3
  • REG-III 3
  • INGAP 3
  • PAP-H 3
  • PBCGF 3
  • REG3 3

External Ids for REG3A Gene

Previous HGNC Symbols for REG3A Gene

  • PAP

Previous GeneCards Identifiers for REG3A Gene

  • GC02M079296
  • GC02M079384

Summaries for REG3A Gene

Entrez Gene Summary for REG3A Gene

  • This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]

GeneCards Summary for REG3A Gene

REG3A (Regenerating Islet-Derived 3 Alpha) is a Protein Coding gene. Diseases associated with REG3A include pancreatitis and cystic fibrosis. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is REG3G.

UniProtKB/Swiss-Prot for REG3A Gene

  • Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.

Gene Wiki entry for REG3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REG3A Gene

Genomics for REG3A Gene

Regulatory Elements for REG3A Gene

Genomic Location for REG3A Gene

Start:
79,157,003 bp from pter
End:
79,159,754 bp from pter
Size:
2,752 bases
Orientation:
Minus strand

Genomic View for REG3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REG3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REG3A Gene

Proteins for REG3A Gene

  • Protein details for REG3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06141-REG3A_HUMAN
    Recommended name:
    Regenerating islet-derived protein 3-alpha
    Protein Accession:
    Q06141
    Secondary Accessions:

    Protein attributes for REG3A Gene

    Size:
    175 amino acids
    Molecular mass:
    19395 Da
    Quaternary structure:
    • Interacts with EXTL3.

    Three dimensional structures from OCA and Proteopedia for REG3A Gene

neXtProt entry for REG3A Gene

Proteomics data for REG3A Gene at MOPED

Post-translational modifications for REG3A Gene

  • Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.

Other Protein References for REG3A Gene

Antibody Products

No data available for DME Specific Peptides for REG3A Gene

Domains for REG3A Gene

Suggested Antigen Peptide Sequences for REG3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q06141

UniProtKB/Swiss-Prot:

REG3A_HUMAN :
  • Q06141
Domain:
  • The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with REG3A: view

No data available for Gene Families for REG3A Gene

Function for REG3A Gene

Molecular function for REG3A Gene

UniProtKB/Swiss-Prot Function: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
UniProtKB/Swiss-Prot Induction: Appears in pancreatic juice after induction of pancreatic inflammation

Gene Ontology (GO) - Molecular Function for REG3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with REG3A: view

Phenotypes for REG3A Gene

genes like me logo Genes that share phenotypes with REG3A: view

Animal Models for REG3A Gene

MGI Knock Outs for REG3A:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REG3A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for REG3A Gene

Localization for REG3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for REG3A Gene

Secreted. Note=Found in the apical region of pancreatic acinar cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REG3A Gene COMPARTMENTS Subcellular localization image for REG3A gene
Compartment Confidence
extracellular 5
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for REG3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 8997243
GO:0005737 cytoplasm TAS 8997243
genes like me logo Genes that share ontologies with REG3A: view

Pathways for REG3A Gene

SuperPathways for REG3A Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for REG3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS 8997243
GO:0007275 multicellular organismal development TAS 8997243
GO:0008283 cell proliferation TAS 8997243
GO:0010838 positive regulation of keratinocyte proliferation ISS --
genes like me logo Genes that share ontologies with REG3A: view

No data available for Pathways by source for REG3A Gene

Compounds for REG3A Gene

(7) Novoseek inferred chemical compound relationships for REG3A Gene

Compound -log(P) Hits PubMed IDs
trypsinogen 68.5 3
probucol 41.4 1
nicotinamide 39.1 1
glucose 14 1
streptozotocin 11.3 2
genes like me logo Genes that share compounds with REG3A: view

Transcripts for REG3A Gene

Unigene Clusters for REG3A Gene

Regenerating islet-derived 3 alpha:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REG3A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REG3A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: -
SP3: -

Relevant External Links for REG3A Gene

GeneLoc Exon Structure for
REG3A
ECgene alternative splicing isoforms for
REG3A

Expression for REG3A Gene

mRNA expression in normal human tissues for REG3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REG3A Gene

This gene is overexpressed in Pancreas (38.1) and Small Intestine - Terminal Ileum (14.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for REG3A Gene

SOURCE GeneReport for Unigene cluster for REG3A Gene Hs.567312

mRNA Expression by UniProt/SwissProt for REG3A Gene

Q06141-REG3A_HUMAN
Tissue specificity: Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.
genes like me logo Genes that share expressions with REG3A: view

In Situ Assay Products

Orthologs for REG3A Gene

This gene was present in the common ancestor of chordates.

Orthologs for REG3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REG3A 35
  • 99.05 (n)
  • 98.29 (a)
REG3A 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTP 36
  • 70 (a)
ManyToMany
REG3G 36
  • 63 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia REG3A 36
  • 74 (a)
ManyToMany
REG3A 36
  • 74 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Reg3a 36
  • 61 (a)
ManyToMany
Reg3b 35
  • 75.1 (n)
  • 69.54 (a)
Reg3b 16
Reg3b 36
  • 69 (a)
ManyToMany
Reg3g 36
  • 66 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Reg3b 35
  • 72.99 (n)
  • 68.97 (a)
chicken
(Gallus gallus)
Aves REG4 36
  • 30 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for REG3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for REG3A Gene

ENSEMBL:
Gene Tree for REG3A (if available)
TreeFam:
Gene Tree for REG3A (if available)

Paralogs for REG3A Gene

Paralogs for REG3A Gene

Selected SIMAP similar genes for REG3A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with REG3A: view

Variants for REG3A Gene

Sequence variations from dbSNP and Humsavar for REG3A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1916179 -- 79,157,207(-) TCAGC(A/G)GCCTG utr-variant-3-prime
rs1916180 -- 79,157,175(-) TGGGC(A/T)TGAGA utr-variant-3-prime
rs2272108 -- 79,159,178(-) GTTAA(A/C)TTGCA intron-variant
rs2272109 -- 79,158,932(-) TACTA(C/T)GGCTA intron-variant
rs2272110 -- 79,158,787(-) TCCCC(C/T)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REG3A Gene

Variant ID Type Subtype PubMed ID
nsv522260 CNV Gain 19592680

Relevant External Links for REG3A Gene

HapMap Linkage Disequilibrium report
REG3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REG3A Gene

Disorders for REG3A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for REG3A Gene including...

Search for REG3A Gene in MalaCards »

(1) University of Copenhagen DISEASES for REG3A Gene

(20) Novoseek inferred disease relationships for REG3A Gene

Disease -log(P) Hits PubMed IDs
acute pancreatitis 71.9 32
pancreatitis 67.4 22
pancreatic diseases 51.8 5
chronic pancreatitis 50.1 5
cystadenoma mucinous 46.8 1

Relevant External Links for REG3A

Genetic Association Database (GAD)
REG3A
Human Genome Epidemiology (HuGE) Navigator
REG3A
genes like me logo Genes that share disorders with REG3A: view

No data available for UniProtKB/Swiss-Prot for REG3A Gene

Publications for REG3A Gene

  1. Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene. (PMID: 8188210) Dusetti N.J. … Iovanna J.L. (Genomics 1994) 2 3 4 23
  2. Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer. (PMID: 8076648) Lasserre C. … Brechot C. (Eur. J. Biochem. 1994) 3 4 23
  3. A novel gene (HIP) activated in human primary liver cancer. (PMID: 1325291) Lasserre C. … Brechot C. (Cancer Res. 1992) 3 4 23
  4. Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases. (PMID: 1469087) Orelle B. … Iovanna J.-L. (J. Clin. Invest. 1992) 3 4 23
  5. Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP). (PMID: 7679928) Itoh T. … Teraoka H. (Biochim. Biophys. Acta 1993) 3 4 23

Products for REG3A Gene

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