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REG1P Gene

pseudogene   GIFtS: 26
GCID: GC02M079363

Regenerating Islet-Derived 1 Pseudogene

(Previous names: rat regenerating islet-derived-like, human homolog (pancreatic...)
(Previous symbol: REGL)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Regenerating Islet-Derived 1 Pseudogene1 2
REGL1 2
Rat Regenerating Islet-Derived-Like, Human Homolog (Pancreatic Stone
Protein-Like, Pancreatic Thread Protein-Like)1
Regenerating Islet-Derived-Like, Pancreatic Stone Protein-Like, Pancreatic
Thread Protein-Like (Rat)1
RS2

External Ids:    HGNC: 99531   Entrez Gene: 59692   Ensembl: ENSG000002047877   
ORGUL members:         

Export aliases for REG1P gene to outside databases

Previous GC identifers: GC02M079218 GC02M079097


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for REG1P Gene:
REG1P (regenerating islet-derived 1 pseudogene) is a pseudogene, and is affiliated with the lncRNA class.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the REG1P gene promoter:
         Bach1   SREBP-1c   CUTL1   LCR-F1   SREBP-1b   Evi-1   AREB6   SREBP-1a   ZID   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REG1P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p12   HGNC cytogenetic band: 2p12

REG1P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REG1P gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M079363:  view genomic region     (about GC identifiers)

Start:
79,362,629 bp from pter      End:
79,365,553 bp from pter
Size:
2,925 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for REG1P

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for REG1P
Interactions:

    Search GeneGlobe Interaction Network for REG1P

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for REG1P



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Unigene Cluster for REG1P:

Regenerating islet-derived 1 pseudogene
Hs.584797  [show with all ESTs]
Unigene Representative Sequence: D56495
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000444841(uc002soa.1) ENST00000377435(uc002sob.1) ENST00000447469
ENST00000414597 ENST00000443710 ENST00000450249 ENST00000434852
miRNA
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Additional mRNA sequence: 

D56494.1 D56495.1 

6 DOTS entries:

DT.308257  DT.102824096  DT.100794212  DT.100794214  DT.120961909  DT.101976696 

20 AceView cDNA sequences:

AA363643 D56494 D56495 NM_006508 AK126561 CD622836 CD622827 AA363642 
BG142191 AA363721 CD622835 CD622831 CD622820 CD622824 CD622828 CD622823 
CD622814 CD622832 CD622818 CD622817 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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REG1P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTCCCCCAT
REG1P Expression
About this image

REG1P Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.584797
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for REG1P (if available)
TreeFam Gene Tree for REG1P (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for REG1P (see all 127)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs104962131,2
C,F,H--79362154(+) TTTATT/GATTCA 1 -- ds500199Minor allele frequency- G:0.13NS EA PA EU CA WA NA 6306
rs729132751,2
C,F--79362244(+) TCAACG/ACTGTA 1 -- ds50011Minor allele frequency- A:0.50WA 2
rs1503733671,2
C--79362322(+) CTTCCA/TCAGGT 1 -- ds50010--------
rs775826601,2
C,F--79362346(+) ACCTCT/CTTAGA 1 -- ds50011Minor allele frequency- C:0.04WA 118
rs1451389551,2
--79362403(+) TGACAC/GTGGGT 1 -- ds50010--------
rs1162824491,2
--79362582(+) CCCAAA/CTACCC 1 -- ds50010--------
rs75953681,2
C,F,H--79362619(+) ACAGAA/GGACAG 1 -- ds50017Minor allele frequency- G:0.09NS EA CSA WA NA 658
rs1490266821,2
--79362624(+) AGACAA/GCACTA 1 -- ds50010--------
rs1120804351,2
C,F--79362625(+) GACAGC/TACTAT 1 -- ds50011Minor allele frequency- T:0.50CSA 2
rs1416637761,2
--79362745(+) ATGGAA/GAGAGA 1 -- nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for REG1P (79362629 - 79365553 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for REG1P:    About this table    
Variant IDTypeSubtypePubMed ID
esv2661607CNV Deletion23128226
nsv522260CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing REG1P
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with REG1P           About GenesLikeMe

Genetic Association Database (GAD): REG1P

Export disorders for REG1P gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for REG1P gene integrated from 10 sources:
(articles sorted by number of sources associating them with REG1P)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human regeneration protein/lithostathine genes map to chromosome 2p12. (PubMed id 8333731)1, 3 Gharib B....Berge-lefranc J.L. (Ann. Hum. Genet. 1993)
  2. Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III. (PubMed id 15556304)1 Nata K.... Okamoto H. (Gene 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. Human REG family genes are tandemly ordered in a 95-kilobase region of chromosome 2p12. (PubMed id 8549770)1 Miyashita H....Okamoto H. (FEBS Lett. 1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5969 HGNC: 9953 AceView: REGL Ensembl:ENSG00000204787 euGenes: HUgn5969
ECgene: REG1P H-InvDB: REG1P

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for REG1P Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for REG1P gene:
Search GeneIP for patents involving REG1P

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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