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REG1B Gene

protein-coding   GIFtS: 59
GCID: GC02M079312

Regenerating Islet-Derived 1 Beta

(Previous names: regenerating islet-derived 1 beta (pancreatic stone protein,...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Regenerating Islet-Derived 1 Beta1 2     Regenerating Islet-Derived Protein 1-Beta2 3
PSPS22 3 5     Regenerating Protein I Beta2 3
REGL2 3 5     PSP-22 3
Regenerating Islet-Derived 1 Beta (Pancreatic Stone Protein, Pancreatic
Thread Protein)1 2
     REG-1-beta2 3
Lithostathine 1 Beta1 2     REGH2
Secretory Pancreatic Stone Protein 21 2     REGI-BETA2
Pancreatic Stone Protein 22 3     lithostathine-1-beta2

External Ids:    HGNC: 99521   Entrez Gene: 59682   Ensembl: ENSG000001720237   OMIM: 1677715   UniProtKB: P483043   
ORGUL members:         

Export aliases for REG1B gene to outside databases

Previous GC identifers: GC02M079449 GC02M079269 GC02M079286 GC02M079223 GC02M079165 GC02M079047


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for REG1B Gene:
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped
into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene
encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related
REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic
lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may
have arisen from the same ancestral gene by gene duplication. (provided by RefSeq, Jul 2008)

GeneCards Summary for REG1B Gene:
REG1B (regenerating islet-derived 1 beta) is a protein-coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is REG3A.

UniProtKB/Swiss-Prot: REG1B_HUMAN, P48304
Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with
neuronal sprouting in brain, and with brain and pancreas regeneration

Gene Wiki entry for REG1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the REG1B gene promoter:
         RP58   NF-1   Brachyury   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   AREB6   CREB   deltaCREB   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREG1B promoter sequence
   Search Chromatin IP Primers for REG1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REG1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p12   HGNC cytogenetic band: 2p12

REG1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REG1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M079312:  view genomic region     (about GC identifiers)

Start:
79,312,149 bp from pter      End:
79,315,150 bp from pter
Size:
3,002 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: REG1B_HUMAN, P48304 (See protein sequence)
Recommended Name: Lithostathine-1-beta precursor  
Size: 166 amino acids; 18665 Da

Explore the universe of human proteins at neXtProt for REG1B: NX_P48304

Explore proteomics data for REG1B at MOPED

Post-translational modifications: 

  • All O-linked glycans consist of Gal-GlcNAc-Gal-GalNAc tetrasaccharide core and get elongated (microheterogeneity)1
  • Glycosylation2 at Thr27
  • Modification sites at PhosphoSitePlus

  • See REG1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006498.1  
    ENSEMBL proteins: 
     ENSP00000387410   ENSP00000303206  

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    LSBio Antibodies in human, mouse, rat for REG1B

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for REG1B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P48304

    ProtoNet protein and cluster: P48304

    2 Blocks protein domains:
    IPB002353 Type II antifreeze protein signature
    IPB003990 Pancreatitis-associated protein signature


    UniProtKB/Swiss-Prot: REG1B_HUMAN, P48304
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with REG1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REG1B_HUMAN, P48304
    Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with
    neuronal sprouting in brain, and with brain and pancreas regeneration

         Genatlas biochemistry entry for REG1B:
    regenerating gene,rat islet-derived homolog 1 beta,expressed in pancreas

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with REG1B           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Reg2):
     behavior/neurological  cellular  homeostasis/metabolism  liver/biliary system  mortality/aging 
     nervous system 

    Find genes that share phenotypes with REG1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Reg2tm1Lchr for REG1B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for REG1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for REG1B

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REG1B

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    1 qRT-PCR Assays for microRNA that regulate REG1B:
    hsa-miR-4305
    SwitchGear 3'UTR luciferase reporter plasmidREG1B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat REG1B

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    REG1B_HUMAN, P48304: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with REG1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for REG1B
    Interactions:

        Search GeneGlobe Interaction Network for REG1B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for REG1B (P483042, 3 ENSP000003032064) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096155P463792, 3MINT-63768 I2D: score=5 
    ENSG00000227761P463792, 3MINT-63768 I2D: score=5 
    ENSG00000228760P463792, 3MINT-63768 I2D: score=5 
    ENSG00000229524P463792, 3MINT-63768 I2D: score=5 
    ENSG00000233348P463792, 3MINT-63768 I2D: score=5 
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    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008283cell proliferation TAS2963000

    Find genes that share ontologies with REG1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for REG1B

    1 HMDB Compound for REG1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for REG1B gene: 
    NM_006507.3  

    Unigene Cluster for REG1B:

    Regenerating islet-derived 1 beta
    Hs.4158  [show with all ESTs]
    Unigene Representative Sequence: AK308507
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454188 ENST00000305089(uc002sny.2) ENST00000479258(uc010ffv.1)
    ENST00000476554(uc010ffw.3) ENST00000469052
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate REG1B:
    hsa-miR-4305
    SwitchGear 3'UTR luciferase reporter plasmidREG1B 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REG1B
      QuantiTect SYBR Green Assays in human, mouse, rat REG1B
      QuantiFast Probe-based Assays in human, mouse, rat REG1B

    Additional mRNA sequence: 

    AK308507.1 AK308515.1 AK311088.1 AK312057.1 BC027895.2 CR450322.1 D16816.1 

    22 DOTS entries:

    DT.120961924  DT.219334  DT.100033806  DT.100794206  DT.97776750  DT.120961904  DT.120961927  DT.120961899 
    DT.100794212  DT.97855959  DT.120961856  DT.120961926  DT.120961903  DT.120961918  DT.120961937  DT.121622358 
    DT.95216068  DT.100794217  DT.120961901  DT.95216013  DT.97855958  DT.97855962 

    Selected AceView cDNA sequences (see all 542):

    CA843214 BU784946 CA844140 BM312203 CR450322 BQ778111 CA943359 BM352084 
    CK902214 CB069699 CA865661 CA941578 BQ287851 CA841658 BU069245 BU950282 
    BM311941 CA844204 AW583356 CA844108 BM504980 W52725 AA363618 BG654649 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    REG1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAGGATTC
    REG1B Expression
    About this image


    REG1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
    REG1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REG1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.4158
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for REG1B gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Reg21 , 5 regenerating islet-derived 21, 5 74.75(n)1
    66.06(a)1
      6 (34.77 cM)5
    196931  NM_009043.11  NP_033069.11 
     784051555 
    chicken
    (Gallus gallus)
    Aves REG46
    Gallus gallus regenerating islet-derived family, m...
    29(a)
    1 → many
    8(4227243-4228652) ENSGALG00000002931
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 28)
    Uncharacterized protein
    (see all 28)
    38(a)
    35(a)
    (see all 28)
    many ↔ many
    many ↔ many
    (see all 28)
    GL343220.1(1307193-1311228)
    GL343799.1(78043-87824)


    ENSEMBL Gene Tree for REG1B (if available)
    TreeFam Gene Tree for REG1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for REG1B gene
    REG3A2  REG42  REG3G2  REG1A2  
    15 SIMAP similar genes for REG1B using alignment to 3 protein entries:     REG1B_HUMAN (see all proteins):
    REG1A    PAP    REG3A    REG3G    REG4    CLEC10A
    COLEC12    MRC1    MRC1L1    ACAN    CLEC17A    MRC2
    LY75    ASGR1    FCER2

    Find genes that share paralogs with REG1B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for REG1B
    PGOHUM00000240107


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for REG1B (see all 193)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124666931,2
    C,F,A,H--79311669(+) ATTTAA/GTTTAC 1 -- ds500112Minor allele frequency- G:0.33NA WA CSA EA 508
    rs750418471,2
    C,F--79311676(+) TTACAT/GAATTG 1 -- ds50011Minor allele frequency- G:0.16WA 118
    rs75832341,2
    C,F,H--79311721(+) TTTAAC/TAAACT 1 -- ds500130Minor allele frequency- T:0.12NS EA NA WA CSA 3326
    rs753837441,2
    C,F--79311732(+) TTGCAC/GGCTGG 1 -- ds50010--------
    rs357404161,2
    C--79311749(+) AAAATG/TTACCA 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs673448331,2
    C--79311749(+) AAAAT-/GTACCA 1 -- ds50010--------
    rs348985551,2
    C--79311751(+) AATGTT/ACCACT 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs621568291,2
    C--79311752(+) ATGTAC/TCACTA 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs75833141,2
    C,F,A,H--79311773(+) GACCGC/TAGACC 1 -- ds500130Minor allele frequency- T:0.46NS EA NA WA CSA 3131
    rs1858267831,2
    --79311937(+) CACACG/TAGGTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for REG1B (79312149 - 79315150 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for REG1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508844CNV Insertion20534489
    nsv2796CNV Loss18451855
    nsv522260CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 167771    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for REG1B:
    Pancreatitis

    Find genes that share disorders with REG1B           About GenesLikeMe

    Genetic Association Database (GAD): REG1B
    Human Genome Epidemiology (HuGE) Navigator: REG1B (1 document)

    Export disorders for REG1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for REG1B gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with REG1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, structural determination and expression of a novel reg gene, human regI beta. (PubMed id 8110835)1, 2, 3 Moriizumi S.... Okamoto H. (Biochim. Biophys. Acta 1994)
    2. A gene homologous to the reg gene is expressed in the human pancreas. (PubMed id 8348956)1, 2, 9 Bartoli C....Berge-Lefranc U. (FEBS Lett. 1993)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. No abnormalities of reg1 alpha and reg1 beta gene associated with diabetes mellitus. (PubMed id 11796176)1, 4 Banchuin N....Yenchitsomanus P.T. (Diabetes Res. Clin. Pract. 2002)
    5. The glycan moiety of human pancreatic lithostathine. Structure characterization and possible pathophysiological implications. (PubMed id 7607222)1, 2 De Reggi M....Fournet B. (Eur. J. Biochem. 1995)
    6. Expression of peptide-23/pancreatitis-associated protein and Reg genes in human pituitary and adenomas: comparison with other fetal and adult human tissues. (PubMed id 9814489)1, 9 Bartoli C....Figarella-Branger D. (J. Clin. Endocrinol. Metab. 1998)
    7. REG1B as a predictor of childhood stunting in Bangladesh and Peru. (PubMed id 23553156)1 Peterson K.M....Petri W.A. (Am. J. Clin. Nutr. 2013)
    8. REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation. (PubMed id 23519454)1 van Beelen Granlund A....Sandvik A.K. (Cell Tissue Res. 2013)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. The expression of REG 1A and REG 1B is increased during acute amebic colitis. (PubMed id 21586335)1 Peterson K.M....Petri W.A. (Parasitol. Int. 2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5968 HGNC: 9952 AceView: REG1B Ensembl:ENSG00000172023 euGenes: HUgn5968
    ECgene: REG1B H-InvDB: REG1B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for REG1B Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_255

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for REG1B gene:
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