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Aliases for REG1B Gene

Aliases for REG1B Gene

  • Regenerating Islet-Derived 1 Beta 2 3
  • Regenerating Islet-Derived 1 Beta (Pancreatic Stone Protein, Pancreatic Thread Protein) 2 3
  • Regenerating Islet-Derived Protein 1-Beta 3 4
  • Secretory Pancreatic Stone Protein 2 2 3
  • Regenerating Protein I Beta 3 4
  • Pancreatic Stone Protein 2 3 4
  • Lithostathine 1 Beta 2 3
  • REG-1-Beta 3 4
  • PSPS2 3 4
  • PSP-2 3 4
  • REGL 3 4
  • Pancreatic Thread Protein-Like) 6
  • Lithostathine-1-Beta 3
  • REGI-BETA 3
  • REGH 3

External Ids for REG1B Gene

Summaries for REG1B Gene

Entrez Gene Summary for REG1B Gene

  • This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

GeneCards Summary for REG1B Gene

REG1B (Regenerating Islet-Derived 1 Beta) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is REG3G.

UniProtKB/Swiss-Prot for REG1B Gene

  • Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration

Gene Wiki entry for REG1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REG1B Gene

Genomics for REG1B Gene

Genomic Location for REG1B Gene

Start:
79,085,023 bp from pter
End:
79,088,024 bp from pter
Size:
3,002 bases
Orientation:
Minus strand

Genomic View for REG1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REG1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REG1B Gene

Regulatory Elements for REG1B Gene

Proteins for REG1B Gene

  • Protein details for REG1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48304-REG1B_HUMAN
    Recommended name:
    Lithostathine-1-beta
    Protein Accession:
    P48304
    Secondary Accessions:

    Protein attributes for REG1B Gene

    Size:
    166 amino acids
    Molecular mass:
    18665 Da
    Quaternary structure:
    No Data Available

neXtProt entry for REG1B Gene

Proteomics data for REG1B Gene at MOPED

Post-translational modifications for REG1B Gene

  • All O-linked glycans consist of Gal-GlcNAc-Gal-GalNAc tetrasaccharide core and get elongated (microheterogeneity).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr27

Other Protein References for REG1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for REG1B Gene

Domains for REG1B Gene

UniProtKB/Swiss-Prot:

REG1B_HUMAN
Domain:
  • Contains 1 C-type lectin domain.:
    • P48304
genes like me logo Genes that share domains with REG1B: view

No data available for Gene Families for REG1B Gene

Function for REG1B Gene

Molecular function for REG1B Gene

GENATLAS Biochemistry: regenerating gene,rat islet-derived homolog 1 beta,expressed in pancreas
UniProtKB/Swiss-Prot Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration

Gene Ontology (GO) - Molecular Function for REG1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with REG1B: view
genes like me logo Genes that share phenotypes with REG1B: view

Animal Models for REG1B Gene

MGI Knock Outs for REG1B:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for REG1B Gene

Localization for REG1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for REG1B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REG1B Gene COMPARTMENTS Subcellular localization image for REG1B gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for REG1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with REG1B: view

Pathways for REG1B Gene

SuperPathways for REG1B Gene

No Data Available

Interacting Proteins for REG1B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000303206%0d%0a9606.ENSP00000365131%0d%0a9606.ENSP00000383938%0d%0a
Selected Interacting proteins: P48304-REG1B_HUMAN ENSP00000303206 for REG1B Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for REG1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation TAS 2963000
genes like me logo Genes that share ontologies with REG1B: view

No data available for Pathways by source for REG1B Gene

Compounds for REG1B Gene

(1) HMDB Compounds for REG1B Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with REG1B: view

Transcripts for REG1B Gene

Unigene Clusters for REG1B Gene

Regenerating islet-derived 1 beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for REG1B Gene

No ASD Table

Relevant External Links for REG1B Gene

GeneLoc Exon Structure for
REG1B
ECgene alternative splicing isoforms for
REG1B

Expression for REG1B Gene

mRNA expression in normal human tissues for REG1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REG1B Gene

This gene is overexpressed in Pancreas (50.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for REG1B Gene

SOURCE GeneReport for Unigene cluster for REG1B Gene Hs.4158

genes like me logo Genes that share expressions with REG1B: view

Orthologs for REG1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for REG1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REG1B 36
  • 99 (n)
  • 98.19 (a)
REG1B 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Reg1 37
  • 71 (a)
ManyToMany
Reg2 36
  • 74.75 (n)
  • 66.06 (a)
Reg2 16
Reg2 37
  • 63 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 39 (a)
ManyToMany
-- 37
  • 39 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
-- 37
  • 43 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
chicken
(Gallus gallus)
Aves REG4 37
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 29 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
-- 37
  • 38 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
-- 37
  • 30 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
-- 37
  • 30 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
-- 37
  • 30 (a)
ManyToMany
-- 37
  • 22 (a)
ManyToMany
-- 37
  • 30 (a)
ManyToMany
-- 37
  • 29 (a)
ManyToMany
-- 37
  • 25 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 30 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 24 (a)
ManyToMany
-- 37
  • 32 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
Species with no ortholog for REG1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for REG1B Gene

ENSEMBL:
Gene Tree for REG1B (if available)
TreeFam:
Gene Tree for REG1B (if available)

Paralogs for REG1B Gene

Paralogs for REG1B Gene

Selected SIMAP similar genes for REG1B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for REG1B Gene

genes like me logo Genes that share paralogs with REG1B: view

Variants for REG1B Gene

Sequence variations from dbSNP and Humsavar for REG1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs983558 -- 79,089,179(+) AAATA(A/G)GGATG upstream-variant-2KB
rs983559 -- 79,089,180(+) AATAA(A/G)GATGG upstream-variant-2KB
rs1375050 -- 79,089,296(+) GCATA(C/T)ATAAA upstream-variant-2KB
rs1403378 -- 79,088,619(-) CCTTC(A/G)TCTCC upstream-variant-2KB
rs1522855 -- 79,085,930(-) TCAAC(A/G)ACTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REG1B Gene

Variant ID Type Subtype PubMed ID
nsv522260 CNV Gain 19592680
nsv508844 CNV Insertion 20534489
nsv2796 CNV Loss 18451855

Relevant External Links for REG1B Gene

HapMap Linkage Disequilibrium report
REG1B

Disorders for REG1B Gene

(1) University of Copenhagen DISEASES for REG1B Gene

Relevant External Links for REG1B

Genetic Association Database (GAD)
REG1B
Human Genome Epidemiology (HuGE) Navigator
REG1B
genes like me logo Genes that share disorders with REG1B: view

No data available for UniProtKB/Swiss-Prot for REG1B Gene

Publications for REG1B Gene

  1. Isolation, structural determination and expression of a novel reg gene, human regI beta. (PMID: 8110835) Moriizumi S. … Okamoto H. (Biochim. Biophys. Acta 1994) 2 3 4
  2. A gene homologous to the reg gene is expressed in the human pancreas. (PMID: 8348956) Bartoli C. … Berge-Lefranc U. (FEBS Lett. 1993) 3 4 23
  3. The glycan moiety of human pancreatic lithostathine. Structure characterization and possible pathophysiological implications. (PMID: 7607222) De Reggi M. … Fournet B. (Eur. J. Biochem. 1995) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. No abnormalities of reg1 alpha and reg1 beta gene associated with diabetes mellitus. (PMID: 11796176) Banchuin N. … Yenchitsomanus P.T. (Diabetes Res. Clin. Pract. 2002) 3 49

Products for REG1B Gene

Sources for REG1B Gene

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