REG1B Gene
protein-coding GIFtS: 56
GCID: GC02M079223
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regenerating islet-derived 1 beta(Previous names: regenerating islet-derived 1 beta (pancreatic stone protein,...)
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Aliases
for REG1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Regenerating Islet-Derived 1 Beta1 2 | | Regenerating Islet-Derived Protein 1-Beta2 3 | | PSPS21 2 3 5 | | Regenerating Protein I Beta2 3 | | REGL1 2 3 5 | | PSP-22 3 | | REGH1 2 | | REG-1-Beta1 | | REGI-BETA1 2 | | Lithostathine 1 Beta2 | | Regenerating Islet-Derived 1 Beta (Pancreatic Stone Protein, Pancreatic ThreadProtein)1 2 | | Lithostathine-1-Beta1 | | Pancreatic Stone Protein 22 3 | | Secretory Pancreatic Stone Protein 22 |
Export aliases for REG1B gene to outside databasesPrevious GC identifers: GC02M079449 GC02M079269 GC02M079286 GC02M079165 GC02M079047 |
Summaries
for REG1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for REG1B:
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped intofour subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes aprotein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein isassociated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg familymembers REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the sameancestral gene by gene duplication. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: REG1B_HUMAN, P48304Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronalsprouting in brain, and with brain and pancreas regeneration
Gene Wiki entry for REG1B
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Genomic Views
for REG1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the REG1B gene promoter:
RP58 NF-1 Brachyury POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 AREB6 CREB deltaCREB ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for REG1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REG1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p12 Ensembl cytogenetic band: 2p12 HGNC cytogenetic band: 2p12REG1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M079223: view genomic region
(about GC identifiers)
Start:
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79,312,149 bp from pter |
End:
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79,315,150 bp from pter |
Size:
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3,002 bases |
Orientation:
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minus strand |
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Proteins
for REG1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: REG1B_HUMAN, P48304 (See
protein sequence)Recommended Name: Lithostathine-1-beta precursor Size: 166 amino acids; 18665 Da
Subcellular location: SecretedExplore the universe of human proteins at neXtProt for REG1B: NX_P48304
Post-translational modifications:
All O-linked glycans consist of Gal-GlcNAc-Gal-GalNAc tetrasaccharide core and get elongated (microheterogeneity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P48304
REG1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006498.1
ENSEMBL proteins: ENSP00000387410 ENSP00000303206
Human Recombinant Protein Products for REG1B:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
REG1B for ontologies About GeneDecksing
REG1B Antibody Products:
Assay Products for REG1B: |
Protein
Domains /
Families
for REG1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
REG1B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P48304ProtoNet protein and cluster: P48304 2 Blocks protein families: IPB002353 Type II antifreeze protein signature IPB003990 Pancreatitis-associated protein signature
UniProtKB/Swiss-Prot: REG1B_HUMAN, P48304Similarity: Contains 1 C-type lectin domain |
Function
for REG1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: REG1B_HUMAN, P48304Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronalsprouting in brain, and with brain and pancreas regeneration Genatlas biochemistry entry for REG1B:regenerating gene,rat islet-derived homolog 1 beta,expressed in pancreas
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030246 | carbohydrate binding |
IEA | -- |
REG1B for ontologies About GeneDecksing
Phenotypes:
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Reg2):
REG1B for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Reg2tm1Lchr for REG1B
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REG1B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REG1B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG1B |
|
Pathways & Interactions
for REG1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for REG1B
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for REG1B (P483042, 3 ENSP000003032064) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
REG1B for ontologies About GeneDecksing
|
Drugs & Compounds
for REG1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for REG1B
1 HMDB Compound for REG1B About this table
Search CenterWatch for drugs/clinical trials and news about REG1B
|
Transcripts
for REG1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for REG1B gene: NM_006507.3 Unigene Cluster for REG1B: Regenerating islet-derived 1 beta Hs.4158 [show with all ESTs]Unigene Representative Sequence: AK3085075 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000454188 ENST00000305089(uc002sny.2) ENST00000479258(uc010ffv.1)
ENST00000476554(uc010ffw.3) ENST00000469052
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REG1B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REG1B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: REG1B (NM_006507) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for REG1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REG1B |
Additional cDNA sequence: AK308507.1 AK308515.1 AK311088.1 AK312057.1 BC027895.2 CR450322.1 D16816.1 22 DOTS entries: DT.120961924 DT.219334 DT.100033806 DT.100794206 DT.97776750 DT.120961904 DT.120961927 DT.120961899 DT.100794212 DT.97855959 DT.120961856 DT.120961926 DT.100794217 DT.120961903 DT.120961918 DT.120961937 DT.121622358 DT.95216068 DT.120961901 DT.95216013 DT.97855958 DT.97855962 24/542 AceView cDNA sequences (see all 542): BU784566 BM311602 BI791469 CA841834 CK902215 BM505145 CA942887 W52725 CA773933 AA295842 BC027895 BM769964 BQ776632 BU951140 AA835225 BQ271997 CA843608 CA841839 CA777292 BM310398 BU949340 BM310821 AA294923 BU076161
GeneLoc Exon Structure
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Expression
for REG1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| REG1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCAGGATTC
About this image
See REG1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for REG1B
SOURCE GeneReport for Unigene cluster: Hs.4158
SABiosciences Custom PCR Arrays for REG1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REG1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REG1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REG1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REG1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG1B |
Orthologs
for REG1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for REG1B gene from 4/8 species (see all 8) About this table
ENSEMBL Gene Tree for REG1B (if available)
TreeFam Gene Tree for REG1B (if available) |
Paralogs
for REG1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for REG1B gene
- REG3A2 REG42 REG3G2 CLEC19A2 REG1A2
16 SIMAP similar genes for REG1B using alignment to 3 protein entries: REG1B_HUMAN (see all proteins):REG1A PAP REG3A REG3G REG4 CLEC10A
COLEC12 MRC1 MRC1L1 ACAN CLEC17A MRC2
LY75 ASGR1 FCER2 PLA2R1
REG1B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for REG1B
PGOHUM00000240107
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Genomic Variants
for REG1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for REG1B (79312149 - 79315150 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for REG1B
1 CNV: 35857 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REG1B |
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Disorders
/ Diseases
for REG1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
REG1B for disorders About GeneDecksing
OMIM gene information: 167771
OMIM disorders: --
8  diseases for REG1B: About MalaCardspancreatitis pituitary adenoma diabetes mellitus adenoma
esophageal cancer alzheimer's disease esophagitis neuronitis
1 disease from the University of Copenhagen DISEASES database for REG1B:Pancreatitis Genetic Association Database (GAD): REG1B
Human Genome Epidemiology (HuGE) Navigator: REG1B (1 document)
Export disorders for REG1B gene to outside databases
|
Publications
for REG1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for REG1B gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with REG1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation, structural determination and expression of a novel reg gene, human regI beta. (PubMed id 8110835)1, 2, 3 Moriizumi S.... Okamoto H. (1994)
- A gene homologous to the reg gene is expressed in the human pancreas. (PubMed id 8348956)1, 2, 9 Bartoli C....Berge-Lefranc U. (1993)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- No abnormalities of reg1 alpha and reg1 beta gene associated with diabetes mellitus. (PubMed id 11796176)1, 4 Banchuin N....Yenchitsomanus P.T. (2002)
- The glycan moiety of human pancreatic lithostathine. Structure characterization and possible pathophysiological implications. (PubMed id 7607222)1, 2 De Reggi M....Fournet B. (1995)
- Expression of peptide-23/pancreatitis-associated protein and Reg genes in human pituitary and adenomas: comparison with other fetal and adult human tissues. (PubMed id 9814489)1, 9 Bartoli C....Figarella-Branger D. (1998)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- The expression of REG 1A and REG 1B is increased durin g acute amebic colitis. (PubMed id 21586335)1 Peterson K.M....Petri W.A. (2011)
- Expression of MK-1 and RegIV and its clinicopathologi cal significances in the benign and malignant lesions of gallbladder. (PubMed id 22018336)1 Yang L....Yang Z. (2011)
- Regenerating gene I regulates interleukin-6 productio n in squamous esophageal cancer cells. (PubMed id 20056108)1 Usami S....Sugiyama T. (2010)
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External Searches for REG1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing REG1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing REG1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing REG1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for REG1B | Pharmacogenomics, SNPs, Pathways | | Functional Glycomics Gateway - Glycan Binding | http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_255 |
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About This Section
| Patent Information for REG1B gene:
Search GeneIP for patents involving REG1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for REG1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for REG1B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REG1B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REG1B | | | OriGene Protein Over-expression Lysate for REG1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for REG1B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REG1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REG1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for REG1B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat REG1B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REG1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REG1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REG1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REG1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REG1B |
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