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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REG1B Gene

protein-coding   GIFtS: 58
GCID: GC02M079223

Regenerating Islet-Derived 1 Beta

(Previous names: regenerating islet-derived 1 beta (pancreatic stone protein,...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regenerating Islet-Derived 1 Beta1 2     Regenerating Islet-Derived Protein 1-Beta2 3
PSPS22 3 5     Regenerating Protein I Beta2 3
REGL2 3 5     PSP-22 3
Regenerating Islet-Derived 1 Beta (Pancreatic Stone Protein, Pancreatic
Thread Protein)1 2
     REG-1-beta2 3
Lithostathine 1 Beta1 2     REGH2
Secretory Pancreatic Stone Protein 21 2     REGI-BETA2
Pancreatic Stone Protein 22 3     lithostathine-1-beta2

External Ids:    HGNC: 99521   Entrez Gene: 59682   Ensembl: ENSG000001720237   OMIM: 1677715   UniProtKB: P483043   

Export aliases for REG1B gene to outside databases

Previous GC identifers: GC02M079449 GC02M079269 GC02M079286 GC02M079165 GC02M079047


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for REG1B Gene:
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped
into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene
encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related
REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic
lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may
have arisen from the same ancestral gene by gene duplication. (provided by RefSeq, Jul 2008)

GeneCards Summary for REG1B Gene: 
REG1B (regenerating islet-derived 1 beta) is a protein-coding gene. Diseases associated with REG1B include pancreatitis, and esophageal cancer. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is REG3A.

UniProtKB/Swiss-Prot: REG1B_HUMAN, P48304
Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with
neuronal sprouting in brain, and with brain and pancreas regeneration

Gene Wiki entry for REG1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REG1B gene promoter:
         RP58   NF-1   Brachyury   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   AREB6   CREB   deltaCREB   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREG1B promoter sequence
   Search SABiosciences Chromatin IP Primers for REG1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REG1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p12   HGNC cytogenetic band: 2p12

REG1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REG1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M079223:  view genomic region     (about GC identifiers)

Start:
79,312,149 bp from pter      End:
79,315,150 bp from pter
Size:
3,002 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: REG1B_HUMAN, P48304 (See protein sequence)
Recommended Name: Lithostathine-1-beta precursor  
Size: 166 amino acids; 18665 Da
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for REG1B: NX_P48304

Explore proteomics data for REG1B at MOPED 

Post-translational modifications:

  • UniProtKB: All O-linked glycans consist of Gal-GlcNAc-Gal-GalNAc tetrasaccharide core and get elongated (microheterogeneity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48304

  • REG1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    REG1B Protein Expression
    REFSEQ proteins: NP_006498.1  
    ENSEMBL proteins: 
     ENSP00000387410   ENSP00000303206  

    Human Recombinant Protein Products for REG1B: 
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    OriGene Purified Protein for REG1B
    OriGene Protein Over-expression Lysate for REG1B
    OriGene MassSpec for REG1B 
    OriGene Custom Protein Services for REG1B
    GenScript Custom Purified and Recombinant Proteins Services for REG1B
    Novus Biologicals REG1B Proteins
    Novus Biologicals REG1B Lysate
    Sino Biological Recombinant Protein for REG1B
    Sino Biological Cell Lysate for REG1B 
    ProSpec Recombinant Protein for REG1B
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    REG1B for ontologies           About GeneDecksing



    REG1B Antibody Products: 
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    Novus Biologicals REG1B Antibody
    Abcam antibodies for REG1B
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for REG1B
    LSBio Antibodies in human, mouse, rat for REG1B 

    Assay Products for REG1B: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for REG1B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P48304

    ProtoNet protein and cluster: P48304

    2 Blocks protein domains:
    IPB002353 Type II antifreeze protein signature
    IPB003990 Pancreatitis-associated protein signature


    UniProtKB/Swiss-Prot: REG1B_HUMAN, P48304
    Similarity: Contains 1 C-type lectin domain


    REG1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REG1B_HUMAN, P48304
    Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with
    neuronal sprouting in brain, and with brain and pancreas regeneration

         Genatlas biochemistry entry for REG1B:
    regenerating gene,rat islet-derived homolog 1 beta,expressed in pancreas

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding IEA--
         
    REG1B for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Reg2):
     behavior/neurological  cellular  homeostasis/metabolism  liver/biliary system  mortality/aging 
     nervous system 

    REG1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Reg2tm1Lchr for REG1B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for REG1B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for REG1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REG1B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REG1B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REG1B
    1 QIAGEN miScript miRNA Assays for microRNA that regulate REG1B:
    hsa-miR-4305
    SwitchGear 3'UTR luciferase reporter plasmidREG1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for REG1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REG1B

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for REG1B
    Sirion Biotech Customized adenovirus for overexpression of REG1B

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for REG1B (see all 6)
    OriGene ORF clones in mouse, rat for REG1B
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    GenScript: all cDNA clones in your preferred vector: REG1B (NM_006507)
    Sino Biological Human cDNA Clone for REG1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REG1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REG1B
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                         Customized lentivirus expression plasmids for stable overexpression of REG1B 

    Cell Line
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    Search LifeMap BioReagents cell lines for REG1B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG1B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for REG1B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/8 Interacting proteins for REG1B (P483042, 3 ENSP000003032064) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096155P463792, 3MINT-63768 I2D: score=5 
    ENSG00000227761P463792, 3MINT-63768 I2D: score=5 
    ENSG00000228760P463792, 3MINT-63768 I2D: score=5 
    ENSG00000229524P463792, 3MINT-63768 I2D: score=5 
    ENSG00000233348P463792, 3MINT-63768 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008283cell proliferation TAS2963000

    REG1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REG1B

    1 HMDB Compound for REG1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about REG1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for REG1B gene: 
    NM_006507.3  

    Unigene Cluster for REG1B:

    Regenerating islet-derived 1 beta
    Hs.4158  [show with all ESTs]
    Unigene Representative Sequence: AK308507
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454188 ENST00000305089(uc002sny.2) ENST00000479258(uc010ffv.1)
    ENST00000476554(uc010ffw.3) ENST00000469052

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REG1B
    1 QIAGEN miScript miRNA Assays for microRNA that regulate REG1B:
    hsa-miR-4305
    SwitchGear 3'UTR luciferase reporter plasmidREG1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for REG1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REG1B
    Clone
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    OriGene clones in human, mouse for REG1B (see all 6)
    OriGene ORF clones in mouse, rat for REG1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REG1B (NM_006507)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REG1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REG1B
    Sirion Biotech Customized lentivirus for stable overexpression of REG1B 
                         Customized lentivirus expression plasmids for stable overexpression of REG1B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for REG1B
    OriGene qSTAR qPCR primer pairs in human, mouse for REG1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REG1B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REG1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REG1B

    Additional mRNA sequence: 

    AK308507.1 AK308515.1 AK311088.1 AK312057.1 BC027895.2 CR450322.1 D16816.1 

    22 DOTS entries:

    DT.120961924  DT.219334  DT.100033806  DT.100794206  DT.97776750  DT.120961904  DT.120961927  DT.120961899 
    DT.100794212  DT.97855959  DT.120961856  DT.120961926  DT.120961903  DT.120961918  DT.120961937  DT.121622358 
    DT.95216068  DT.100794217  DT.120961901  DT.95216013  DT.97855958  DT.97855962 

    24/542 AceView cDNA sequences (see all 542):

    CA844108 CA943359 BQ778254 BM510074 BQ778476 BG654418 BM310821 CA843214 
    BQ631715 CB069699 AA294923 AA313018 BI791507 BM311564 BU069038 NM_006507 
    BM310694 AW583335 AA835225 CK902690 BU784946 CA942887 AA588704 CA867510 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REG1B expression in normal human tissues (normalized intensities)      REG1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAGGATTC
    REG1B Expression
    About this image


    REG1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Duct Cells Pancreatic Ducts
             pancreas ; exocrine glandular cells   
             Pancreatic Islet   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine ; glandular cells   
             duodenum   

    See REG1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REG1B

    SOURCE GeneReport for Unigene cluster: Hs.4158
        SABiosciences Custom PCR Arrays for REG1B
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REG1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for REG1B gene from 4/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Reg21 , 5 regenerating islet-derived 21, 5 74.55(n)1
    66.06(a)1
      6 (34.77 cM)5
    196931  NM_009043.11  NP_033069.11 
     784051555 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 10)
    Uncharacterized protein
    (see all 10)
    33(a)
    31(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    GL343442.1(588370-592837)
    GL343442.1(335200-340404)
    zebrafish
    (Danio rerio)
    Actinopterygii REG1A6
    si:dkey-9i23.46
    (see all 4)
    si:dkey-9i23.4
    (see all 4)
    24(a)
    14(a)
    (see all 4)
    1 ↔ many
    possible ortholog
    (see all 4)
    1(9070895-9076445)
    1(45223135-45225533)
    worm
    (Caenorhabditis elegans)
    Secernentea clec-1616
    Y38H6C.86
    (see all 3)
    Protein Y38H6C.8
    (see all 3)
    3(a)
    20(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(9603026-9608688)
    V(20514766-20515706)


    ENSEMBL Gene Tree for REG1B (if available)
    TreeFam Gene Tree for REG1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for REG1B gene
    REG3A2  REG42  REG3G2  REG1A2  
    15 SIMAP similar genes for REG1B using alignment to 3 protein entries:     REG1B_HUMAN (see all proteins):
    REG1A    PAP    REG3A    REG3G    REG4    CLEC10A
    COLEC12    MRC1    MRC1L1    ACAN    CLEC17A    MRC2
    LY75    ASGR1    FCER2

    REG1B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for REG1B
    PGOHUM00000240107


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/193 SNPs in REG1B are shown (see all 193)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124666931,2
    C,F,A,H--79311669(+) ATTTAA/GTTTAC 1 -- ds500112Minor allele frequency- G:0.33NA WA CSA EA 508
    rs750418471,2
    C,F--79311676(+) TTACAT/GAATTG 1 -- ds50011Minor allele frequency- G:0.16WA 118
    rs75832341,2
    C,F,H--79311721(+) TTTAAC/TAAACT 1 -- ds500130Minor allele frequency- T:0.12NS EA NA WA CSA 3326
    rs753837441,2
    C,F--79311732(+) TTGCAC/GGCTGG 1 -- ds50010--------
    rs357404161,2
    C--79311749(+) AAAATG/TTACCA 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs673448331,2
    C--79311749(+) AAAAT-/GTACCA 1 -- ds50010--------
    rs348985551,2
    C--79311751(+) AATGTT/ACCACT 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs621568291,2
    C--79311752(+) ATGTAC/TCACTA 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs75833141,2
    C,F,A,H--79311773(+) GACCGC/TAGACC 1 -- ds500130Minor allele frequency- T:0.46NS EA NA WA CSA 3131
    rs1858267831,2
    --79311937(+) CACACG/TAGGTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for REG1B (79312149 - 79315150 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for REG1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508844CNV Insertion20534489
    nsv2796CNV Loss18451855
    nsv522260CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing REG1B
    DNA2.0 Custom Variant and Variant Library Synthesis for REG1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 167771    OMIM disorders: --

    8 diseases for REG1B:    About MalaCards
    pancreatitis    esophageal cancer    pituitary adenoma    adenoma
    esophagitis    diabetes mellitus    alzheimer's disease    neuronitis

    1 disease from the University of Copenhagen DISEASES database for REG1B:
    Pancreatitis

    REG1B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): REG1B
    Human Genome Epidemiology (HuGE) Navigator: REG1B (1 document)

    Export disorders for REG1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REG1B gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with REG1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, structural determination and expression of a novel reg gene, human regI beta. (PubMed id 8110835)1, 2, 3 Moriizumi S.... Okamoto H. (1994)
    2. A gene homologous to the reg gene is expressed in the human pancreas. (PubMed id 8348956)1, 2, 9 Bartoli C....Berge-Lefranc U. (1993)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. No abnormalities of reg1 alpha and reg1 beta gene associated with diabetes mellitus. (PubMed id 11796176)1, 4 Banchuin N....Yenchitsomanus P.T. (2002)
    5. The glycan moiety of human pancreatic lithostathine. Structure characterization and possible pathophysiological implications. (PubMed id 7607222)1, 2 De Reggi M....Fournet B. (1995)
    6. Expression of peptide-23/pancreatitis-associated protein and Reg genes in human pituitary and adenomas: comparison with other fetal and adult human tissues. (PubMed id 9814489)1, 9 Bartoli C....Figarella-Branger D. (1998)
    7. REG1B as a predictor of childhood stunting in Banglade sh and Peru. (PubMed id 23553156)1 Peterson K.M....Petri W.A. (2013)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. The expression of REG 1A and REG 1B is increased durin g acute amebic colitis. (PubMed id 21586335)1 Peterson K.M....Petri W.A. (2011)
    10. Expression of MK-1 and RegIV and its clinicopathologi cal significances in the benign and malignant lesions of gallbladder. (PubMed id 22018336)1 Yang L....Yang Z. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5968 HGNC: 9952 AceView: REG1B Ensembl:ENSG00000172023 euGenes: HUgn5968
    ECgene: REG1B H-InvDB: REG1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REG1B Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_255

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for REG1B gene:
    Search GeneIP for patents involving REG1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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