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Aliases for REG1B Gene

Aliases for REG1B Gene

  • Regenerating Islet-Derived 1 Beta 2 3
  • Regenerating Islet-Derived 1 Beta (Pancreatic Stone Protein, Pancreatic Thread Protein) 2 3
  • Regenerating Islet-Derived Protein 1-Beta 3 4
  • Secretory Pancreatic Stone Protein 2 2 3
  • Regenerating Protein I Beta 3 4
  • Pancreatic Stone Protein 2 3 4
  • Lithostathine 1 Beta 2 3
  • REG-1-Beta 3 4
  • PSP-2 3 4
  • PSPS2 3 4
  • REGL 3 4
  • REGI-BETA 3
  • REGH 3

External Ids for REG1B Gene

Previous GeneCards Identifiers for REG1B Gene

  • GC02M079449
  • GC02M079269
  • GC02M079286
  • GC02M079223
  • GC02M079165
  • GC02M079312

Summaries for REG1B Gene

Entrez Gene Summary for REG1B Gene

  • This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

GeneCards Summary for REG1B Gene

REG1B (Regenerating Islet-Derived 1 Beta) is a Protein Coding gene. Diseases associated with REG1B include pancreatitis. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is REG3G.

UniProtKB/Swiss-Prot for REG1B Gene

  • Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration

Gene Wiki entry for REG1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REG1B Gene

Genomics for REG1B Gene

Regulatory Elements for REG1B Gene

Genomic Location for REG1B Gene

Chromosome:
2
Start:
79,085,023 bp from pter
End:
79,088,024 bp from pter
Size:
3,002 bases
Orientation:
Minus strand

Genomic View for REG1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REG1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REG1B Gene

Proteins for REG1B Gene

  • Protein details for REG1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48304-REG1B_HUMAN
    Recommended name:
    Lithostathine-1-beta
    Protein Accession:
    P48304

    Protein attributes for REG1B Gene

    Size:
    166 amino acids
    Molecular mass:
    18665 Da
    Quaternary structure:
    No Data Available

neXtProt entry for REG1B Gene

Proteomics data for REG1B Gene at MOPED

Post-translational modifications for REG1B Gene

  • All O-linked glycans consist of Gal-GlcNAc-Gal-GalNAc tetrasaccharide core and get elongated (microheterogeneity).
  • Glycosylation at Thr 27
  • Modification sites at PhosphoSitePlus

Other Protein References for REG1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for REG1B Gene

Domains & Families for REG1B Gene

Graphical View of Domain Structure for InterPro Entry

P48304

UniProtKB/Swiss-Prot:

REG1B_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with REG1B: view

No data available for Gene Families for REG1B Gene

Function for REG1B Gene

Molecular function for REG1B Gene

GENATLAS Biochemistry:
regenerating gene,rat islet-derived homolog 1 beta,expressed in pancreas
UniProtKB/Swiss-Prot Function:
Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration

Gene Ontology (GO) - Molecular Function for REG1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with REG1B: view
genes like me logo Genes that share phenotypes with REG1B: view

Animal Models for REG1B Gene

MGI Knock Outs for REG1B:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REG1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for REG1B Gene

Localization for REG1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for REG1B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REG1B Gene COMPARTMENTS Subcellular localization image for REG1B gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for REG1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with REG1B: view

Pathways & Interactions for REG1B Gene

SuperPathways for REG1B Gene

No Data Available

Interacting Proteins for REG1B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000303206%0d%0a9606.ENSP00000365131%0d%0a9606.ENSP00000383938%0d%0a
Selected Interacting proteins: P48304-REG1B_HUMAN ENSP00000303206 for REG1B Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for REG1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation TAS 2963000
genes like me logo Genes that share ontologies with REG1B: view

No data available for Pathways by source and SIGNOR curated interactions for REG1B Gene

Drugs & Compounds for REG1B Gene

(1) Drugs for REG1B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with REG1B: view

Transcripts for REG1B Gene

Unigene Clusters for REG1B Gene

Regenerating islet-derived 1 beta:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REG1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REG1B Gene

No ASD Table

Relevant External Links for REG1B Gene

GeneLoc Exon Structure for
REG1B
ECgene alternative splicing isoforms for
REG1B

Expression for REG1B Gene

mRNA expression in normal human tissues for REG1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REG1B Gene

This gene is overexpressed in Pancreas (x50.4).

Protein differential expression in normal tissues from HIPED for REG1B Gene

This gene is overexpressed in Islet of Langerhans (62.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for REG1B Gene



SOURCE GeneReport for Unigene cluster for REG1B Gene Hs.4158

genes like me logo Genes that share expression patterns with REG1B: view

Protein tissue co-expression partners for REG1B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for REG1B Gene

Orthologs for REG1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for REG1B Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Reg2 35
  • 74.75 (n)
  • 66.06 (a)
Reg2 16
Reg1 36
  • 71 (a)
ManyToMany
Reg2 36
  • 63 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia REG1B 35
  • 99 (n)
  • 98.19 (a)
REG1B 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
chicken
(Gallus gallus)
Aves REG4 36
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for REG1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for REG1B Gene

ENSEMBL:
Gene Tree for REG1B (if available)
TreeFam:
Gene Tree for REG1B (if available)

Paralogs for REG1B Gene

Paralogs for REG1B Gene

(15) SIMAP similar genes for REG1B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for REG1B Gene

genes like me logo Genes that share paralogs with REG1B: view

Variants for REG1B Gene

Sequence variations from dbSNP and Humsavar for REG1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs983558 -- 79,089,179(+) AAATA(A/G)GGATG upstream-variant-2KB
rs983559 -- 79,089,180(+) AATAA(A/G)GATGG upstream-variant-2KB
rs1375050 -- 79,089,296(+) GCATA(C/T)ATAAA upstream-variant-2KB
rs1403378 -- 79,088,619(-) CCTTC(A/G)TCTCC upstream-variant-2KB
rs1522855 -- 79,085,930(-) TCAAC(A/G)ACTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REG1B Gene

Variant ID Type Subtype PubMed ID
nsv522260 CNV Gain 19592680
nsv508844 CNV Insertion 20534489
nsv2796 CNV Loss 18451855

Variation tolerance for REG1B Gene

Residual Variation Intolerance Score: 74.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REG1B Gene

HapMap Linkage Disequilibrium report
REG1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REG1B Gene

Disorders for REG1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for REG1B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatitis
- elite association
Search REG1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for REG1B

Genetic Association Database (GAD)
REG1B
Human Genome Epidemiology (HuGE) Navigator
REG1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REG1B
genes like me logo Genes that share disorders with REG1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REG1B Gene

Publications for REG1B Gene

  1. Expression of peptide-23/pancreatitis-associated protein and Reg genes in human pituitary and adenomas: comparison with other fetal and adult human tissues. (PMID: 9814489) Bartoli C. … Figarella-Branger D. (J. Clin. Endocrinol. Metab. 1998) 23 67
  2. The rat genes encoding the pancreatitis-associated proteins I, II and III (Pap1, Pap2, Pap3), and the lithostathin/pancreatic stone protein/regeneration protein (Reg) colocalize at 4q33-->q34. (PMID: 8565642) Stephanova E. … Szpirer C. (Cytogenet. Cell Genet. 1996) 23 67
  3. Isolation, structural determination and expression of a novel reg gene, human regI beta. (PMID: 8110835) Moriizumi S. … Okamoto H. (Biochim. Biophys. Acta 1994) 2 67
  4. A gene homologous to the reg gene is expressed in the human pancreas. (PMID: 8348956) Bartoli C. … Berge-Lefranc U. (FEBS Lett. 1993) 23 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for REG1B Gene

Sources for REG1B Gene

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