Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REG1A Gene

protein-coding   GIFtS: 63
GCID: GC02P079347

regenerating islet-derived 1 alpha

(Previous names: regenerating islet-derived 1 alpha (pancreatic stone protein,...)
(Previous symbol: REG)
 Explore 41 diseases affiliated with
REG1A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for REG1A    

Aliases
for REG1A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Regenerating Islet-Derived 1 Alpha1 2     Regenerating Protein I Alpha2 3
PSPS11 2 3 5     ICRF2 3
REG1 2 3 5     REG-1-Alpha1
PSP1 2 3     Regenerating Islet-Derived 1 Alpha (Pancreatic Stone Protein, Pancreatic Thread
Protein)1
PSPS1 2 3     P192
PTP1 2 3     Lithostathine 1 Alpha2
Islet Cells Regeneration Factor2 3     Lithostathine-1-Alpha1
Islet Of Langerhans Regenerating Protein2 3     Pancreatic Stone Protein, Secretory2
Pancreatic Thread Protein2 3     Protein-X1
Regenerating Islet-Derived Protein 1-Alpha2 3     Pancreatic Stone Protein3

External Ids:    HGNC: 99511   Entrez Gene: 59672   Ensembl: ENSG000001153867   OMIM: 1677705   UniProtKB: P054513   

Export aliases for REG1A gene to outside databases

Previous GC identifers: GC02P079485 GC02P079305 GC02P079322 GC02P079259 GC02P079201 GC02P079082


Summaries
for REG1A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for REG1A:
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into
four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a
protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis
and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly
clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal
sprouting in brain, and with brain and pancreas regeneration

Gene Wiki entry for REG1A


Genomic Views
for REG1A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REG1A gene promoter:
         AP-2rep   RP58   NF-1   GATA-3   CUTL1   NF-kappaB   STAT3   ZID   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: REG1A promoter sequence
   Search SABiosciences Chromatin IP Primers for REG1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REG1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p12   HGNC cytogenetic band: 2p12

REG1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REG1A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P079347:  view genomic region     (about GC identifiers)

Start:
 79,347,488 bp from pter      End:
 79,350,545 bp from pter
Size:
 3,058 bases      Orientation:
 plus strand

Proteins
for REG1A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451 (See protein sequence)
Recommended Name: Lithostathine-1-alpha precursor  
Size: 166 amino acids; 18731 Da
Subcellular location: Secreted
Developmental stage: High expression levels in fetal and infant brains; much lower in adult brains
2 PDB 3D structures from and Proteopedia for REG1A:
1LIT (3D)        1QDD (3D)    
Secondary accessions: P11379 Q4ZG28

Explore the universe of human proteins at neXtProt for REG1A: NX_P05451

Post-translational modifications:

  • The composition of the O-linked carbohydrate on Thr-27 is complex and varied. In the crystallographic structure, the
    • attached sugar appears to be N-acetylglucosamine, typical of an intracellular protein, rather than
    N-acetylgalactosamine1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P05451

    • REG1A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002900.2  
    ENSEMBL proteins: 
     ENSP00000233735  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: REG1A
    OriGene Protein Over-expression Lysate: REG1A
    OriGene Custom Protein Services for REG1A 
    GenScript Custom Purified and Recombinant Proteins Services for REG1A
    Novus Biologicals REG1A Proteins
    Novus Biologicals REG1A Lysate
    Sino Biological Recombinant Protein for REG1A
    ProSpec Recombinant Protein for REG1A
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    REG1A for ontologies           About GeneDecksing



    REG1A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for REG1A
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for REG1A 
    GenScript Custom Superior Antibodies Services for REG1A
    Novus Biologicals REG1A Antibodies
    Search for Antibodies for REG1A at Abcam  
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for REG1A

    Assay Products for REG1A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for REG1A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for REG1A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    REG1A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P05451

    ProtoNet protein and cluster: P05451

    2 Blocks protein families:
    IPB002353 Type II antifreeze protein signature
    IPB003990 Pancreatitis-associated protein signature


    UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
    Similarity: Contains 1 C-type lectin domain


    Function
    for REG1A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
    Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal
    sprouting in brain, and with brain and pancreas regeneration

         Genatlas biochemistry entry for REG1A:
    regenerating gene,rat islet-derived homolog 1 alpha,expressed in kidney,stomach,pancreas,involved in beta cells
    proliferation

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REG1A
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate REG1A
    SwitchGear 3'UTR luciferase reporter plasmid: REG1A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REG1A (see all 4)
    OriGene shRNA RFP: REG1A
    OriGene siRNA: REG1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REG1A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for REG1A

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REG1A (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REG1A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: REG1A (NM_002909)
    Sino Biological Human cDNA Clone for REG1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REG1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REG1A 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for REG1A
    Search LifeMap BioReagents cell lines for REG1A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG1A

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity IDA10526060
    GO:0030246carbohydrate binding IEA--


    REG1A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for REG1A:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Reg1tm1Okam for REG1A
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Reg1):
     endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    REG1A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for REG1A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Insulin Signaling
    		Insulin Signaling1.00
    2Type II interferon signaling (IFNG)
    		Type II interferon signaling (IFNG)1.00


    2 BioSystems Pathways for REG1A 
        Type II interferon signaling (IFNG)
    Insulin Signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for REG1A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for REG1A (P054513 ENSP000002337354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    REG3AQ061413, ENSP000003043114I2D: score=1 STRING: ENSP00000304311
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation TAS2332435


    REG1A for ontologies           About GeneDecksing



    Drugs & Compounds
    for REG1A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    REG1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REG1A

    1 HMDB Compound for REG1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for REG1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    O-Sialic Acid-- --target--17139284 17016423
    Phosphonoserine-- --target--10592235

    10 Novoseek chemical compound relationships for REG1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium carbonate 61.1 7 8482198 (1), 8333731 (1), 9006958 (1), 1985964 (1) (see all 5)
    trypsinogen 49.9 1 11884767 (1)
    nicotinamide 36 1 8767167 (1)
    phosphoserine 34.7 3 11342136 (2), 14983068 (1)
    pyruvate 11.5 2 9067533 (1), 10590436 (1)
    genistein 8.41 1 16793699 (1)
    thymidine 1.13 3 8613011 (1), 9823399 (1)
    glucose 0 6 18953250 (4)
    tyrosine 0 3 8764975 (1), 19807095 (1)
    serine 0 2 11342136 (1)

    Search CenterWatch for drugs/clinical trials and news about REG1A 

    Transcripts
    for REG1A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for REG1A gene: 
    NM_002909.4  

    Unigene Cluster for REG1A:

    Regenerating islet-derived 1 alpha
    Hs.49407  [show with all ESTs]
    Unigene Representative Sequence: BI838728
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488524(uc010ffx.1) ENST00000233735(uc002snz.3 uc010ysd.2)
    ENST00000461579 ENST00000485184

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REG1A
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate REG1A
    SwitchGear 3'UTR luciferase reporter plasmid: REG1A 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REG1A (see all 4)
    OriGene shRNA RFP: REG1A
    OriGene siRNA: REG1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REG1A
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REG1A (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REG1A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: REG1A (NM_002909)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REG1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REG1A 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REG1A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REG1A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REG1A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REG1A

    Additional cDNA sequence: 

    AF172331.1 AK291981.1 AK307292.1 AK311087.1 BC005350.2 BC110438.2 BC118544.1 BC118621.1 
    M18963.1 

    24/25 DOTS entries (see all 25):

    DT.120961919  DT.97855959  DT.120961917  DT.95216056  DT.100794214  DT.95255502  DT.97855960  DT.120961900 
    DT.95216013  DT.100794207  DT.100033806  DT.100033807  DT.120961929  DT.219334  DT.120961860  DT.120961923 
    DT.120961931  DT.87008522  DT.95216000  DT.97855961  DT.97855965  DT.100794212  DT.120961901  DT.97855958 

    24/1321 AceView cDNA sequences (see all 1321):

    BU784668 BQ632619 BQ269515 BQ269441 BQ286276 BM310683 BU790368 BQ417502 
    BU948873 CK821610 BQ777062 BM352940 CA867577 BQ417295 BQ631896 AW583574 
    BU785337 CA951125 CA771541 BM769769 BQ084233 BM314735 BQ286424 CA949906 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for REG1A    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d
    SP1:                                                        -                           
    SP2:                                                        -     -                     
    SP3:                                -                       -                           
    SP4:                                                                                    
    SP5:                                -     -     -           -                           


    ECgene alternative splicing isoforms for REG1A

    Expression
    for REG1A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REG1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCCACTAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    REG1A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See REG1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REG1A

    SOURCE GeneReport for Unigene cluster: Hs.49407

    UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
    Tissue specificity: In pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related
    transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down
    syndrome patients

        SABiosciences Custom PCR Arrays for REG1A
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REG1A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REG1A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REG1A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REG1A
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG1A

    Orthologs
    for REG1A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for REG1A gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves REG46
    --
    (see all 3)    		 Uncharacterized protein
    (see all 3)    		 28(a)
    17(a)
    (see all 3)    		 1 ↔ many
    possible ortholog
    (see all 3)    		 8(4268626-4270305)
    1(170863522-170871287)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 14)    		 --
    		 34(a)
    33(a)
    (see all 14)    		 many ↔ many
    many ↔ many
    (see all 14)    		 GL343442.1(588370-592837)
    GL343442.1(335200-340404)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-241l7.26
    si:dkey-241l7.46
    (see all 16)    		 si:dkey-241l7.4
    (see all 16)    		 29(a)
    29(a)
    (see all 16)    		 many ↔ many
    many ↔ many
    (see all 16)    		 20(54389663-54390997)
    20(54379710-54381098)
    worm
    (Caenorhabditis elegans)    		 Secernentea clec-1486
    clec-526
    (see all 7)    		 C-type LECtin family member (clec-52)
    (see all 7)    		 22(a)
    15(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 III(174608-175832)
    IV(8167149-8168760)


    ENSEMBL Gene Tree for REG1A (if available)
    TreeFam Gene Tree for REG1A (if available) 

    Paralogs
    for REG1A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for REG1A gene
    REG3A2  REG42  REG3G2  CLEC19A2  REG1B2  
    18/23 SIMAP similar genes for REG1A using alignment to 2 protein entries:     REG1A_HUMAN (see all proteins) (see all similar genes):
    REG1B    PAP    REG3A    REG3G    REG4    KLRC2
    KLRC3    ACAN    CSPG3 variant protein    KLRC1    NCAN    ASGR2
    MRC2    FCER2    VCAN    DKFZp686K06110    CLEC17A    MRC1

    REG1A for paralogs           About GeneDecksing



    Genomic Variants
    for REG1A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/141 NCBI SNPs in REG1A are shown (see all 141)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2009693011,2
    		C,other79084446(+) GAATTC/TGGGCA 2 S L mis10--------
    rs1135898841,2
    		C,F,--79081085(+) TTGCAG/ATGAGC 1 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs101938471,2
    		C,--79081233(+) AATTGA/CTTGTT 1 -- us2k1 tfbs30--------
    rs743502461,2
    		C,F,--79081309(+) GTTAAC/TGGAAG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs729132591,2
    		C,--79082257(+) ACTCAG/ATTTCA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs786024891,2
    		C,F,--79082977(+) AAGGGC/TGTCTC 1 -- int11Minor allele frequency- T:0.16WA 118
    rs749032731,2
    		--79083013(+) TTCGGG/AAAGAT 1 -- int11Minor allele frequency- A:0.01NA 120
    rs794588451,2
    		F,--79083081(+) AAGTTG/ATTTTT 1 -- int11Minor allele frequency- A:0.09WA 118
    rs729132611,2
    		C,F,--79083217(+) TCTCCG/ATCTCT 1 -- int13Minor allele frequency- A:0.50WA CSA 6
    rs102004741,2
    		C,--79083246(+) GTTCTC/GCTATA 1 -- int12Minor allele frequency- G:0.03CSA WA 120

    HapMap Linkage Disequilibrium report for REG1A (79347488 - 79350545 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for REG1A
         1 CNV: 35858

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REG1A
    DNA2.0 Custom Variant and Variant Library Synthesis for REG1A

    Disorders / Diseases
    for REG1A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    REG1A for disorders           About GeneDecksing

    OMIM gene information: 167770    OMIM disorders: --

    20/41 diseases for REG1A (see all 41):    About MalaCards
    pancreatitis    choledochal cyst    tropical calcific pancreatitis    multiple endocrine neoplasia
    primary biliary cirrhosis    acinar cell carcinoma    barrett's esophagus    liver cirrhosis
    diabetes mellitus    pituitary adenoma    ulcerative colitis    acute pancreatitis
    cystic fibrosis    nephropathy    cerebral atherosclerosis    hereditary pancreatitis
    celiac disease    hepatocellular carcinoma    alzheimer's disease    down syndrome

    1 disease from the University of Copenhagen DISEASES database for REG1A:
    Pancreatitis

    10/28 Novoseek disease relationships for REG1A gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreas exocrine 71.8 6 8333731 (1), 7607222 (1), 8348956 (1), 8825811 (1) (see all 5)
    chronic pancreatitis 68.2 14 1698685 (2), 7716137 (2), 8482198 (1), 11249074 (1) (see all 11)
    carcinoma acinar cell 65.9 1 1525759 (1)
    pancreatic diseases 54.6 2 19325491 (1), 1698685 (1)
    pancreatitis hereditary 54.3 7 1578808 (3)
    pancreatitis 53.1 15 11884767 (2), 16360171 (2), 8482198 (1), 18953250 (1) (see all 8)
    acute pancreatitis 42.2 5 8501356 (2)
    paired helical filament 39.7 3 2394826 (1), 10329440 (1)
    calculi 38.4 1 11884767 (1)
    colorectal tumors 38 3 9834348 (1), 12455032 (1)

    Genetic Association Database (GAD): REG1A
    Human Genome Epidemiology (HuGE) Navigator: REG1A (4 documents)

    Export disorders for REG1A gene to outside databases

    Publications
    for REG1A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REG1A gene, integrated from 9 sources (see all 159):
    (articles sorted by number of sources associating them with REG1A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. (PubMed id 2332435)1, 2, 3, 9 Watanabe T.... Okamoto H. (1990)
    2. Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain. (PubMed id 2394826)1, 2, 9 de la Monte S.M.... Wands J.R. (1990)
    3. Human regeneration protein/lithostathine genes map to chromosome 2p12. (PubMed id 8333731)1, 3, 9 Gharib B....Berge-lefranc J.L. (1993)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. No abnormalities of reg1 alpha and reg1 beta gene associated with diabetes mellitus. (PubMed id 11796176)1, 4 Banchuin N....Yenchitsomanus P.T. (2002)
    7. Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine. (PubMed id 10625646)1, 2 Gerbaud V.... Verdier J.-M. (2000)
    8. Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation. (PubMed id 8654365)1, 2 Bertrand J.A....Fontecilla-Camps J.-C. (1996)
    9. What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy. (PubMed id 8961348)1, 2 Patard L....de Reggi M. (1996)
    10. Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae. (PubMed id 2226837)1, 2 Itoh T.... Okamoto H. (1990)

    External Searches for REG1A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing REG1A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5967 HGNC: 9951 AceView: REG1A Ensembl:ENSG00000115386 euGenes: HUgn5967
    ECgene: REG1A H-InvDB: REG1A

    Other Databases showing REG1A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing REG1A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REG1A Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_254

    Intellectual Property
    for REG1A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for REG1A gene:
    Search GeneIP for patents involving REG1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for REG1A gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for REG1A (Reg1A)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for REG1A  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REG1A   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REG1A  
     OriGene Protein Over-expression Lysate for REG1A   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for REG1A   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REG1A   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REG1A  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for REG1A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for REG1A   OriGene Custom Protein Services for REG1A  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat REG1A
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REG1A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REG1A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REG1A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REG1A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REG1A
     GenScript Custom Purified and Recombinant Proteins Services for REG1A GenScript cDNA clones with any tag delivered in your preferred vector for REG1A
     GenScript Custom Assay Services for REG1A GenScript Custom Superior Antibodies Services for REG1A
     GenScript Custom overexpressing Cell Line Services for REG1A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in REG1A promoter
     Search Chromatin IP Primers for REG1A
     RT2 qPCR Primer Assay in human, mouse, rat REG1A
     GNC Network for REG1A
     SABiosciences Custom PCR Arrays for REG1A
     Search Tocris compounds for REG1A
     Proteins and Antibodies for REG1A
     cDNA Clones for REG1A
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     REG1A antibodies
     REG1A proteins
     REG1A lysates
     Search for Antibodies for REG1A at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for REG1A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for REG1A




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for REG1A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG1A
     SwitchGear 3'UTR luciferase reporter plasmids for REG1A
     SwitchGear Promoter luciferase reporter plasmids for REG1A
     ThermoFisher Antibodies for REG1A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REG1A
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      REG1A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4