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REG1A Gene

protein-coding   GIFtS: 60

GC02P079201
regenerating islet-derived 1 alpha
(Previous names: regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: REG)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
ICRF 2, 3
MGC12447 2
OTTHUMP00000160485 2
P19 2
PSP 1, 2, 3
PSPS 1, 2, 3
PSPS1 1, 2, 5
PTP 1, 2, 3
REG 2, 3, 5
protein-X 2
Descriptions
Islet cells regeneration factor 2, 3
Islet of Langerhans regenerating protein 2, 3
Pancreatic stone protein 3
Pancreatic thread protein 2, 3
Regenerating protein I alpha 2, 3
lithostathine 1 alpha 2
pancreatic stone protein, secretory 2
regenerating islet-derived 1 alpha 2
regenerating islet-derived 1 alpha (pancreatic stone
protein, pancreatic thread protein) 1, 2
External Ids
HGNC: 99511
Entrez Gene: 59672
UniProtKB: P054513
Ensembl: ENSG000001153867
Search outside databases for aliases for REG1A gene

Previous GC identifers: GC02P079485 GC02P079305 GC02P079322 GC02P079259

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for REG1A:
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene
family grouped into four subclasses, types I, II, III and IV, based on the primary structures of
the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is
associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic
lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on
chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by
RefSeq]

UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be
associated with neuronal sprouting in brain, and with brain and pancreas regeneration

Gene Wiki entry for REG1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the REG1A gene  

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p12   HGNC cytogenetic band: 2p12

REG1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P079201:     (about GC identifiers)

Start:
79,201,092 bp from pter
End:
79,204,053 bp from pter
Size:
2,962 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_022184.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451 (See protein sequence)
Recommended Name: Lithostathine-1-alpha precursor  
Size: 166 amino acids; 18731 Da
Developmental stage: High expression levels in fetal and infant brains; much lower in adult brains
Caution: The composition of the O-linked carbohydrate on Thr-27 is complex and varied. In the
crystallographic structure, the attached sugar appears to be N-acetylglucosamine, typical of an
intracellular protein, rather than N-acetylgalactosamine
PDB structure from and Proteopedia :
1LIT (3D)    1QDD (3D)    
Secondary accessions: P11379

REFSEQ proteins: NP_002900.2  

ENSEMBL proteins: 
ENSP00000233735 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (REG1 alpha)
Human Recombinant Proteins from Abnova (REG1A)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for REG1A: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for REG1A
R&D Systems Antibodies for REG1A (Reg IA)
Antibodies from Abcam (REG1 alpha), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (REG1A)
Novus Biologicals Antibodies for REG1A

Assays for REG1A: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

4 InterPro domains/families:
 IPR018378 C-type_lectin_CS
 IPR016186 C-type_lectin-like
 IPR001304 C-type_lectin
 IPR003990 Pancreatis_ac


   GeneDecks  REG1A for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P05451

ProtoNet protein and cluster: P05451

2 Blocks protein families:
IPB002353 Type II antifreeze protein signature
IPB003990 Pancreatitis-associated protein signature


UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
Similarity: Contains 1 C-type lectin domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (REG1A)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (REG1A)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002909

              Applied Biosystems Silencer® siRNAs for REG1A

              Sigma-Aldrich siRNA for REG1A  
                     Sigma-Aldrich shRNA for REG1A  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for REG1A
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002909
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002909
                                 untagged cDNA clone in CMV expression vector: NM_002909 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_002909

UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be
associated with neuronal sprouting in brain, and with brain and pancreas regeneration

Genatlas biochemistry entry for REG1A:
regenerating gene,rat islet-derived homolog 1 alpha,expressed in kidney,stomach,pancreas,involved
in beta cells proliferation

4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Reg1):

digestive/alimentaryendocrine/exocrine glandhomeostasis/metabolismreproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005488 binding IEA--
GO:0005529 sugar binding IEA--
GO:0008083 growth factor activity IDA10526060
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  REG1A 


2 Interacting proteins for REG1A (ENSP000002337353) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
REG1PENSP000003666533STRING (score=.794)
PSMA1ENSP000003153093STRING (score=.73)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008284 positive regulation of cell proliferation TAS2332435
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for REG1A
6 Novoseek chemical compound relationships for REG1A gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
trypsinogen 50.98 1 11884767 (1)
phosphoserine 35.89 3 11342136 (2), 14983068 (1)
pyruvate 12.98 2 9067533 (1), 10590436 (1)
thymidine 2.15 3 8613011 (1), 9823399 (1)
glucose 0.00 6 18953250 (4)
tyrosine 0.00 1 8764975 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (REG1A)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (REG1A)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002909

              Sigma-Aldrich siRNA for REG1A  
                     Sigma-Aldrich shRNA for REG1A  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_002909  

REFSEQ mRNAs for REG1A gene: 

NM_002909.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_002909  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002909
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002909
                                 untagged cDNA clone in CMV expression vector: NM_002909 

Additional cDNA sequence: 

AF172331.1 AK291981.1 AK307292.1 AK311087.1 BC005350.2 BC110438.2 BC118544.1 BC118621.1 
M18963.1 

24/25 DOTS entries (see all 25 ):

DT.120961919  DT.97855959  DT.120961917  DT.95216056  DT.100794214  DT.95255502  DT.97855960  DT.120961900 
DT.95216013  DT.100794207  DT.100033806  DT.100033807  DT.120961929  DT.219334  DT.120961860  DT.120961923 
DT.120961931  DT.87008522  DT.95216000  DT.97855961  DT.97855965  DT.100794212  DT.120961901  DT.97855958 

24/1321 AceView cDNA sequences (see all 1321 ):

BU072157 BQ270015 BM819090 BU076592 BI712948 AA294982 BQ632713 CB177241 
AA377242 BM352940 BM314640 BM352982 BM855530 BM769179 BM768947 BI792022 
BU072881 BM272085 BQ417502 BU948873 BQ777298 BM798918 BM311075 BQ084161 

highest scoring ESTs for REG1A:

AI763065 AA164267 AA164696 AA295638 AA363725 AA363732 AA363742 AA363752 AA363788 AA363811 

Unigene Cluster for REG1A:

Regenerating islet-derived 1 alpha
Hs.49407  [show with all ESTs]
Unigene Representative Sequence: BI838728


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for REG1A

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d
SP1:                                                        -                           
SP2:                                                        -     -                     
SP3:                                -                       -                           
SP4:                                                                                    
SP5:                                -     -     -           -                           

About this scheme

ECgene alternative splicing isoforms for REG1A

1 Ensembl transcript including schematic representation:
ENST00000233735  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

REG1A expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for REG1A

1 / 2 / 3

4 probe-sets matching REG1A gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
38646_s_at2, 3 U95-A 1 1.00 1.00 0.99 0.82 AI763065 1.00 1.00 1.00 1
73054_at2, 3 U95-E 1 1.00 1.00 0.99 1.22 C06075 0.80 1.00 0.91 1

209752_at2, 3 U133-A 2 1.00 0.86 -- -- AF172331 0.80 1.00 0.91 1

209752_at2 U133Plus2 2 1.00 0.86 -- -- -- -- -- -- --
GeneDecks  REG1A for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TTTCCACTAT

SOURCE GeneReport for Unigene cluster: Hs.49407

Expression variation in blood from EXPOLDB for REG1A

UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
Tissue specificity: In pancreatic acinar cells and, in lower levels, in brain

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for REG1A gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
REG1A1   -- regenerating islet-derived 1 alpha 99.6(n)
99.4(a)
459348  XM_001163699.1  XP_001163699.1 
rat
(Rattus norvegicus)
Reg1a1   -- regenerating islet-derived 1 alpha 76.6(n)
69.57(a)
24714  NM_012641.1  NP_036773.1 
mouse
(Mus musculus)
Reg11, 5 6 (33.50 cM)5
regenerating islet-derived 11, 5 79.3(n)1
74.53(a)1
196921  NM_009042.11  NP_033068.11 
 AB0352155  AB0352195  (see all 10)
About this table        Species with no ortholog for REG1A

ENSEMBL Gene Tree for REG1A
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for REG1A gene
REG3A2  REG3G2  REG1B2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/67 NCBI SNPs in REG1A are shown (see all 67 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 45)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs13490771,2
A,C,F,H79200558(+) CTTAGG/ACATCA 1 -- ng514Minor allele frequency- A:0.33EU EA WA 410
rs120721,2
A,C,F,H79204013(-) ATTTAA/GGGTTC 1 -- ut31 ese315Minor allele frequency- T:0.03EA NS MN EU WA 1140
rs122281,2
C,F,H79203855(+) AGGCAG/ACTGGA 1 -- ut31 ese35Minor allele frequency- A:0.02MN EU EA WA 604
--
rs101654621,2
C,F79201111(+) ACAGCT/CACCTG 1 -- ut512Minor allele frequency- C:0.40MN EA 356
--
rs18232581,2
A,C79199955(+) ctcatC/Gtcagt 1 -- ng51 tfbs30--------
rs2838891,2
A,C79200995(+) GGCTCA/GTACTG 1 -- ng510--------
--
rs2838851,2
A,C79199306(+) cagacA/Tccatc 1 -- ng51 tfbs30--------
--
rs2838861,2
C79199745(+) acctcC/Tacttc 1 -- ng510--------
rs15228641,2
F79203936(-) AGGTTG/AAGTTG 1 -- ut31 ese31Minor allele frequency- A:0.03MN 184
rs126115771,2
C79200683(+) AGGTTG/TGTGAG 1 -- ng510--------
About this table

HapMap Linkage Disequilibrium images for REG1A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 167770

UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
  • Alzheimer disease and Down syndrome patients show enhanced expression of PSP-related
    transcripts and intraneuronal accumulation of PSP-like proteins in their brains
  • 10/28 Novoseek disease relationships for REG1A gene (see all 28 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreas exocrine 72.48 6 8333731 (1), 7607222 (1), 8348956 (1), 8825811 (1) (see all 5)
    chronic pancreatitis 68.03 13 1698685 (2), 7716137 (2), 8482198 (1), 11249074 (1) (see all 10)
    carcinoma acinar cell 67.36 1 1525759 (1)
    pancreatic diseases 55.74 2 19325491 (1), 1698685 (1)
    pancreatitis hereditary 55.54 7 1578808 (3)
    pancreatitis 54.40 15 11884767 (2), 16360171 (2), 8482198 (1), 18953250 (1) (see all 8)
    acute pancreatitis 43.63 5 8501356 (2)
    paired helical filament 40.61 3 2394826 (1), 10329440 (1)
    calculi 39.82 1 11884767 (1)
    colorectal tumors 39.58 3 9834348 (1), 12455032 (1)
    About this table

    Genetic Association Database: REG1A
    Human Genome Epidemiology Navigator: REG1A (2 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/141 PubMed articles for REG1A gene (see all 141 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 5967 HGNC: 9951 AceView: REG1A Ensembl:ENSG00000115386 euGenes: HUgn5967
    ECgene: REG1A H-InvDB: REG1A
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_254
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for REG1A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for REG1A Antibodies for REG1A
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for REG1A Browse small molecules at Sigma-Aldrich
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     Antibodies for REG1A

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