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REG1A Gene

protein-coding   GIFtS: 63
GCID: GC02P079347

Regenerating Islet-Derived 1 Alpha

(Previous names: regenerating islet-derived 1 alpha (pancreatic stone protein,...)
(Previous symbol: REG)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Regenerating Islet-Derived 1 Alpha1 2     PSP2 3
REG1 2 3 5     PSPS2 3
Pancreatic Thread Protein1 2 3     PTP2 3
PSPS12 3 5     REG-1-alpha2 3
Pancreatic Stone Protein1 3     Regenerating Islet-Derived 1 Alpha (Pancreatic Stone Protein, Pancreatic
Thread Protein)1
Islet Cells Regeneration Factor2 3     P192
Islet Of Langerhans Regenerating Protein2 3     Lithostathine 1 Alpha2
Regenerating Islet-Derived Protein 1-Alpha2 3     lithostathine-1-alpha2
Regenerating Protein I Alpha2 3     Pancreatic Stone Protein, Secretory2
ICRF2 3     protein-X2

External Ids:    HGNC: 99511   Entrez Gene: 59672   Ensembl: ENSG000001153867   OMIM: 1677705   UniProtKB: P054513   
ORGUL members:         

Export aliases for REG1A gene to outside databases

Previous GC identifers: GC02P079485 GC02P079305 GC02P079322 GC02P079259 GC02P079201 GC02P079082


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for REG1A Gene:
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped
into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene
encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and
diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene
are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.
(provided by RefSeq, Jul 2008)

GeneCards Summary for REG1A Gene:
REG1A (regenerating islet-derived 1 alpha) is a protein-coding gene. Diseases associated with REG1A include fibrocalculous pancreatic diabetes, and cerebral atherosclerosis. GO annotations related to this gene include carbohydrate binding and growth factor activity. An important paralog of this gene is REG3A.

UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with
neuronal sprouting in brain, and with brain and pancreas regeneration

Gene Wiki entry for REG1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the REG1A gene promoter:
         AP-2rep   RP58   NF-1   GATA-3   CUTL1   NF-kappaB   STAT3   ZID   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREG1A promoter sequence
   Search Chromatin IP Primers for REG1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REG1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p12   HGNC cytogenetic band: 2p12

REG1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REG1A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P079347:  view genomic region     (about GC identifiers)

Start:
79,347,488 bp from pter      End:
79,350,545 bp from pter
Size:
3,058 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451 (See protein sequence)
Recommended Name: Lithostathine-1-alpha precursor  
Size: 166 amino acids; 18731 Da
Developmental stage: High expression levels in fetal and infant brains; much lower in adult brains
2 PDB 3D structures from and Proteopedia for REG1A:
1LIT (3D)        1QDD (3D)    
Secondary accessions: P11379 Q4ZG28

Explore the universe of human proteins at neXtProt for REG1A: NX_P05451

Explore proteomics data for REG1A at MOPED

Post-translational modifications: 

  • The composition of the O-linked carbohydrate on Thr-27 is complex and varied. In the crystallographic structure,
    the attached sugar appears to be N-acetylglucosamine, typical of an intracellular protein, rather than
    N-acetylgalactosamine1
  • Glycosylation2 at Thr27
  • Modification sites at PhosphoSitePlus

  • See REG1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002900.2  
    ENSEMBL proteins: 
     ENSP00000233735  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P05451

    ProtoNet protein and cluster: P05451

    2 Blocks protein domains:
    IPB002353 Type II antifreeze protein signature
    IPB003990 Pancreatitis-associated protein signature


    UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
    Similarity: Contains 1 C-type lectin domain


    REG1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REG1A_HUMAN, P05451
    Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with
    neuronal sprouting in brain, and with brain and pancreas regeneration

         Genatlas biochemistry entry for REG1A:
    regenerating gene,rat islet-derived homolog 1 alpha,expressed in kidney,stomach,pancreas,involved in beta cells
    proliferation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity IDA10526060
    GO:0030246carbohydrate binding IEA--
         
    REG1A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for REG1A:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Reg1):
     endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    REG1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Reg1tm1Okam for REG1A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for REG1A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for REG1A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    REG1A_HUMAN, P05451: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    REG1A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for REG1A About    
    See pathways by source

    SuperPathContained pathways About
    1Type II interferon signaling (IFNG)
    Type II interferon signaling (IFNG)
    2Insulin Signaling
    Insulin Signaling


    2 BioSystems Pathways for REG1A
        Insulin Signaling
    Type II interferon signaling (IFNG)



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for REG1A
    Interactions:

        GeneGlobe Interaction Network for REG1A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for REG1A (P054513 ENSP000002337354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    REG3AQ061413, ENSP000003043114I2D: score=1 STRING: ENSP00000304311
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation TAS2332435

    REG1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for REG1A

    1 HMDB Compound for REG1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for REG1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    O-Sialic Acid-- --target--17139284 17016423
    Phosphonoserine-- --target--10592235

    10 Novoseek inferred chemical compound relationships for REG1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium carbonate 61.1 7 8482198 (1), 8333731 (1), 9006958 (1), 1985964 (1) (see all 5)
    trypsinogen 49.9 1 11884767 (1)
    nicotinamide 36 1 8767167 (1)
    phosphoserine 34.7 3 11342136 (2), 14983068 (1)
    pyruvate 11.5 2 9067533 (1), 10590436 (1)
    genistein 8.41 1 16793699 (1)
    thymidine 1.13 3 8613011 (1), 9823399 (1)
    glucose 0 6 18953250 (4)
    tyrosine 0 3 8764975 (1), 19807095 (1)
    serine 0 2 11342136 (1)



    REG1A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for REG1A gene: 
    NM_002909.4  

    Unigene Cluster for REG1A:

    Regenerating islet-derived 1 alpha
    Hs.49407  [show with all ESTs]
    Unigene Representative Sequence: BI838728
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488524(uc010ffx.1) ENST00000233735(uc002snz.3 uc010ysd.2)
    ENST00000461579 ENST00000485184
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat REG1A

    Additional mRNA sequence: 

    AF172331.1 AK291981.1 AK307292.1 AK311087.1 BC005350.2 BC110438.2 BC118544.1 BC118621.1 
    M18963.1 

    Selected DOTS entries (see all 25):

    DT.120961919  DT.97855959  DT.120961917  DT.95216056  DT.100794214  DT.95255502  DT.97855960  DT.120961900 
    DT.95216013  DT.100794207  DT.100033806  DT.100033807  DT.120961929  DT.219334  DT.120961860  DT.120961923 
    DT.120961931  DT.87008522  DT.95216000  DT.97855961  DT.97855965  DT.100794212  DT.120961901  DT.97855958 

    Selected AceView cDNA sequences (see all 1321):

    CA848540 BM314534 BM090900 CA866305 BM798918 BQ632713 BM314640 BM825544 
    BQ417072 BM272085 BU952054 BU786568 CA867623 BQ777355 BM311075 CA771335 
    BM768947 AA295135 BU951645 CK824997 BQ269441 BQ777931 BQ269515 CK826066 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for REG1A    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d
    SP1:                                                        -                           
    SP2:                                                        -     -                     
    SP3:                                -                       -                           
    SP4:                                                                                    
    SP5:                                -     -     -           -                           


    ECgene alternative splicing isoforms for REG1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    REG1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCACTAT
    REG1A Expression
    About this image


    REG1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Colon (Gastrointestinal Tract)
     
     Gall Bladder (Hepatobiliary System)
    REG1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REG1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.49407

    UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
    Tissue specificity: In pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related
    transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down
    syndrome patients

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for REG1A gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Reg11 , 5 regenerating islet-derived 11, 5 79.3(n)1
    74.53(a)1
      6 (34.77 cM)5
    196921  NM_009042.11  NP_033068.11 
     784259835 
    chicken
    (Gallus gallus)
    Aves REG46
    Gallus gallus regenerating islet-derived family, m...
    28(a)
    1 → many
    8(4227243-4228652) ENSGALG00000002931
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 28)
    Uncharacterized protein
    (see all 28)
    38(a)
    34(a)
    (see all 28)
    many ↔ many
    many ↔ many
    (see all 28)
    GL343220.1(1307193-1311228)
    GL343220.1(1322473-1325653)


    ENSEMBL Gene Tree for REG1A (if available)
    TreeFam Gene Tree for REG1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for REG1A gene
    REG3A2  REG42  REG3G2  REG1B2  
    Selected SIMAP similar genes for REG1A using alignment to 2 protein entries:     REG1A_HUMAN (see all proteins) (see all similar genes):
    REG1B    PAP    REG3A    REG3G    REG4    KLRC2
    KLRC3    ACAN    CSPG3 variant protein    KLRC1    NCAN    ASGR2
    MRC2    FCER2    VCAN    DKFZp686K06110    CLEC17A    MRC1

    REG1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for REG1A (see all 167)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009693011,2
    Cuntested179213691(+) GAATTC/TGGGCA 2 S L mis10--------
    rs1889319401,2
    --79080899(+) TGAGGA/CAGGCA 1 -- us2k10--------
    rs19644751,2
    C,F--79210243(+) CCCAGG/CTACTC 1 -- us2k14Minor allele frequency- C:0.38NA 8
    rs1932473511,2
    --79210277(+) AATGGC/TGTGAA 1 -- us2k10--------
    rs1837147181,2
    --79210293(+) AAGGCA/GGAGCT 1 -- us2k10--------
    rs1135898841,2
    C,F--79210303(+) TTGCAG/ATGAGC 1 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs1882246391,2
    --79210308(+) GTGAGA/CTGAGA 1 -- us2k10--------
    rs2838851,2
    C,A--79210353(+) cagacA/Tccatc 1 -- us2k1 tfbs39Minor allele frequency- T:0.00NA WA CSA 16
    rs1807490801,2
    --79210404(+) AAAACA/GTTATG 1 -- us2k10--------
    rs101938471,2
    C--79210451(+) AATTGA/CTTGTT 1 -- us2k1 tfbs30--------

    HapMap Linkage Disequilibrium report for REG1A (79347488 - 79350545 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for REG1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2796CNV Loss18451855
    nsv522260CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 167770    OMIM disorders: --

    Selected diseases for REG1A (see all 38):    
    About MalaCards
    fibrocalculous pancreatic diabetes    cerebral atherosclerosis    pancreatitis    choledochal cyst
    tropical calcific pancreatitis    acinar cell carcinoma    hereditary pancreatitis    acute pancreatitis
    diabetic nephropathy    multiple endocrine neoplasia    liver cirrhosis    barrett's esophagus
    seminoma    esophageal cancer    gastric adenocarcinoma    primary biliary cirrhosis
    celiac disease    pituitary adenoma    pancreatic cancer    ulcerative colitis

    1 disease from the University of Copenhagen DISEASES database for REG1A:
    Pancreatitis

    REG1A for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for REG1A gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreas exocrine 71.8 6 8333731 (1), 7607222 (1), 8348956 (1), 8825811 (1) (see all 5)
    chronic pancreatitis 68.2 14 1698685 (2), 7716137 (2), 8482198 (1), 11249074 (1) (see all 11)
    carcinoma acinar cell 65.9 1 1525759 (1)
    pancreatic diseases 54.6 2 19325491 (1), 1698685 (1)
    pancreatitis hereditary 54.3 7 1578808 (3)
    pancreatitis 53.1 15 11884767 (2), 16360171 (2), 8482198 (1), 18953250 (1) (see all 8)
    acute pancreatitis 42.2 5 8501356 (2)
    paired helical filament 39.7 3 2394826 (1), 10329440 (1)
    calculi 38.4 1 11884767 (1)
    colorectal tumors 38 3 9834348 (1), 12455032 (1)

    Genetic Association Database (GAD): REG1A
    Human Genome Epidemiology (HuGE) Navigator: REG1A (4 documents)

    Export disorders for REG1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for REG1A gene, integrated from 10 sources (see all 165):
    (articles sorted by number of sources associating them with REG1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. (PubMed id 2332435)1, 2, 3, 9 Watanabe T.... Okamoto H. (J. Biol. Chem. 1990)
    2. Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain. (PubMed id 2394826)1, 2, 9 de la Monte S.M.... Wands J.R. (J. Clin. Invest. 1990)
    3. Human regeneration protein/lithostathine genes map to chromosome 2p12. (PubMed id 8333731)1, 3, 9 Gharib B....Berge-lefranc J.L. (Ann. Hum. Genet. 1993)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis. (PubMed id 17990360)1, 4 Mahurkar S....Chandak G.R. (World J. Gastroenterol. 2007)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. No abnormalities of reg1 alpha and reg1 beta gene associated with diabetes mellitus. (PubMed id 11796176)1, 4 Banchuin N....Yenchitsomanus P.T. (Diabetes Res. Clin. Pract. 2002)
    9. Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine. (PubMed id 10625646)1, 2 Gerbaud V.... Verdier J.-M. (J. Biol. Chem. 2000)
    10. Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation. (PubMed id 8654365)1, 2 Bertrand J.A....Fontecilla-Camps J.-C. (EMBO J. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5967 HGNC: 9951 AceView: REG1A Ensembl:ENSG00000115386 euGenes: HUgn5967
    ECgene: REG1A H-InvDB: REG1A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for REG1A Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_254

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for REG1A gene:
    Search GeneIP for patents involving REG1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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