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Aliases for REG1A Gene

Aliases for REG1A Gene

  • Regenerating Islet-Derived 1 Alpha 2 3
  • Pancreatic Thread Protein 2 3 4
  • Regenerating Islet-Derived Protein 1-Alpha 3 4
  • Islet Of Langerhans Regenerating Protein 3 4
  • Islet Cells Regeneration Factor 3 4
  • Regenerating Protein I Alpha 3 4
  • Pancreatic Stone Protein 2 4
  • REG-1-Alpha 3 4
  • PSPS1 3 4
  • ICRF 3 4
  • PSPS 3 4
  • PTP 3 4
  • PSP 3 4
  • REG 3 4
  • Regenerating Islet-Derived 1 Alpha (Pancreatic Stone Protein, Pancreatic Thread Protein) 2
  • Pancreatic Stone Protein, Secretory 3
  • Lithostathine 1 Alpha 3
  • Protein-X 3
  • P19 3

External Ids for REG1A Gene

Previous HGNC Symbols for REG1A Gene

  • REG

Previous GeneCards Identifiers for REG1A Gene

  • GC02P079485
  • GC02P079305
  • GC02P079322
  • GC02P079259
  • GC02P079201
  • GC02P079082
  • GC02P079347

Summaries for REG1A Gene

Entrez Gene Summary for REG1A Gene

  • This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

GeneCards Summary for REG1A Gene

REG1A (Regenerating Islet-Derived 1 Alpha) is a Protein Coding gene. Diseases associated with REG1A include acinar cell carcinoma and tropical calcific pancreatitis. Among its related pathways are Insulin Signaling and Type II interferon signaling (IFNG). GO annotations related to this gene include carbohydrate binding and growth factor activity. An important paralog of this gene is REG3G.

UniProtKB/Swiss-Prot for REG1A Gene

  • Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration

Gene Wiki entry for REG1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REG1A Gene

Genomics for REG1A Gene

Regulatory Elements for REG1A Gene

Genomic Location for REG1A Gene

Chromosome:
2
Start:
79,120,362 bp from pter
End:
79,123,419 bp from pter
Size:
3,058 bases
Orientation:
Plus strand

Genomic View for REG1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REG1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REG1A Gene

Proteins for REG1A Gene

  • Protein details for REG1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05451-REG1A_HUMAN
    Recommended name:
    Lithostathine-1-alpha
    Protein Accession:
    P05451
    Secondary Accessions:
    • P11379
    • Q4ZG28

    Protein attributes for REG1A Gene

    Size:
    166 amino acids
    Molecular mass:
    18731 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for REG1A Gene

neXtProt entry for REG1A Gene

Proteomics data for REG1A Gene at MOPED

Post-translational modifications for REG1A Gene

  • The composition of the O-linked carbohydrate on Thr-27 is complex and varied. In the crystallographic structure, the attached sugar appears to be N-acetylglucosamine, typical of an intracellular protein, rather than N-acetylgalactosamine.
  • Glycosylation at Thr 27
  • Modification sites at PhosphoSitePlus

Other Protein References for REG1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for REG1A Gene

Domains & Families for REG1A Gene

Graphical View of Domain Structure for InterPro Entry

P05451

UniProtKB/Swiss-Prot:

REG1A_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with REG1A: view

No data available for Gene Families for REG1A Gene

Function for REG1A Gene

Molecular function for REG1A Gene

GENATLAS Biochemistry:
regenerating gene,rat islet-derived homolog 1 alpha,expressed in kidney,stomach,pancreas,involved in beta cells proliferation
UniProtKB/Swiss-Prot Function:
Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration

Gene Ontology (GO) - Molecular Function for REG1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IDA 10526060
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with REG1A: view
genes like me logo Genes that share phenotypes with REG1A: view

Animal Models for REG1A Gene

MGI Knock Outs for REG1A:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REG1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for REG1A Gene

Localization for REG1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for REG1A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REG1A Gene COMPARTMENTS Subcellular localization image for REG1A gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for REG1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with REG1A: view

Pathways & Interactions for REG1A Gene

genes like me logo Genes that share pathways with REG1A: view

Pathways by source for REG1A Gene

2 BioSystems pathways for REG1A Gene

Interacting Proteins for REG1A Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000233735%0d%0a9606.ENSP00000304311%0d%0a9606.ENSP00000356641%0d%0a9606.ENSP00000347560%0d%0a
Selected Interacting proteins: ENSP00000233735 P05451-REG1A_HUMAN for REG1A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for REG1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation TAS 2332435
genes like me logo Genes that share ontologies with REG1A: view

No data available for SIGNOR curated interactions for REG1A Gene

Drugs & Compounds for REG1A Gene

(10) Drugs for REG1A Gene - From: NovoSeek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium carbonate Approved Pharma 185
O-Sialic Acid Experimental Pharma Target 0
Phosphonoserine Experimental Pharma Target 0
thymidine Experimental Pharma 0
Nicotinamide Experimental Nutra 332,340

(3) Additional Compounds for REG1A Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glucose
phosphoserine
  • 3-O-Phosphoserine
  • Dexfosfoserine
  • Fosforina
  • L-3-Phosphoserine
  • L-O-Phosphoserine
407-41-0
Trypsinogen
genes like me logo Genes that share compounds with REG1A: view

Transcripts for REG1A Gene

Unigene Clusters for REG1A Gene

Regenerating islet-derived 1 alpha:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REG1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REG1A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3: - -
SP4:
SP5: - - - -

Relevant External Links for REG1A Gene

GeneLoc Exon Structure for
REG1A
ECgene alternative splicing isoforms for
REG1A

Expression for REG1A Gene

mRNA expression in normal human tissues for REG1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REG1A Gene

This gene is overexpressed in Pancreas (x49.8).

Protein differential expression in normal tissues from HIPED for REG1A Gene

This gene is overexpressed in Islet of Langerhans (44.0) and Pancreatic juice (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for REG1A Gene



SOURCE GeneReport for Unigene cluster for REG1A Gene Hs.49407

mRNA Expression by UniProt/SwissProt for REG1A Gene

P05451-REG1A_HUMAN
Tissue specificity: In pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down syndrome patients.
genes like me logo Genes that share expression patterns with REG1A: view

Protein tissue co-expression partners for REG1A Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for REG1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for REG1A Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Reg1 35
  • 79.3 (n)
  • 74.53 (a)
Reg1 16
Reg1 36
  • 74 (a)
ManyToMany
Reg2 36
  • 65 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia REG1A 35
  • 99.6 (n)
  • 99.4 (a)
REG1A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Reg1a 35
  • 76.94 (n)
  • 70.44 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
chicken
(Gallus gallus)
Aves REG4 36
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
Species with no ortholog for REG1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for REG1A Gene

ENSEMBL:
Gene Tree for REG1A (if available)
TreeFam:
Gene Tree for REG1A (if available)

Paralogs for REG1A Gene

Paralogs for REG1A Gene

genes like me logo Genes that share paralogs with REG1A: view

Variants for REG1A Gene

Sequence variations from dbSNP and Humsavar for REG1A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs12072 -- 79,123,379(-) ATTTA(A/G)GGTTC utr-variant-3-prime
rs12228 -- 79,123,221(+) AGGCA(A/G)CTGGA utr-variant-3-prime
rs283885 -- 79,118,672(+) cagac(A/T)ccatc upstream-variant-2KB
rs283886 -- 79,119,111(+) ACCTC(C/T)ACTTC upstream-variant-2KB
rs283887 -- 79,119,888(+) TGAAG(C/G)CTGAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for REG1A Gene

Variant ID Type Subtype PubMed ID
nsv522260 CNV Gain 19592680
nsv2796 CNV Loss 18451855

Variation tolerance for REG1A Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REG1A Gene

HapMap Linkage Disequilibrium report
REG1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REG1A Gene

Disorders for REG1A Gene

MalaCards: The human disease database

(8) MalaCards diseases for REG1A Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
acinar cell carcinoma
  • acinic cell carcinoma
tropical calcific pancreatitis
  • fibrocalculous pancreatic diabetes
pancreatitis
pancreatitis, hereditary
  • pancreatitis, chronic
pancreas disease
  • pancreatic diseases
- elite association
Search REG1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for REG1A

Genetic Association Database (GAD)
REG1A
Human Genome Epidemiology (HuGE) Navigator
REG1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REG1A
genes like me logo Genes that share disorders with REG1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REG1A Gene

Publications for REG1A Gene

  1. Human regeneration protein/lithostathine genes map to chromosome 2p12. (PMID: 8333731) Gharib B. … Berge-lefranc J.L. (Ann. Hum. Genet. 1993) 2 23 67
  2. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. (PMID: 2332435) Watanabe T. … Okamoto H. (J. Biol. Chem. 1990) 2 23 67
  3. Involvement of the IL-22/REG Ialpha axis in ulcerative colitis. (PMID: 20065946) Sekikawa A. … Fujimori T. (Lab. Invest. 2010) 23 67
  4. Confirmation of a novel siadenovirus species detected in raptors: partial sequence and phylogenetic analysis. (PMID: 19061925) KovA!cs E.R. … Benko M. (Virus Res. 2009) 23 67
  5. Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation. (PMID: 19254208) Medveczky P. … Sahin-Toth M. (Biochem. J. 2009) 23 67

Products for REG1A Gene

Sources for REG1A Gene

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