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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REG1A Gene

protein-coding   GIFtS: 62
GCID: GC02P079347

Regenerating Islet-Derived 1 Alpha

(Previous names: regenerating islet-derived 1 alpha (pancreatic stone protein,...)
(Previous symbol: REG)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regenerating Islet-Derived 1 Alpha1 2     PSP2 3
REG1 2 3 5     PSPS2 3
Pancreatic Thread Protein1 2 3     PTP2 3
PSPS12 3 5     REG-1-alpha2 3
Pancreatic Stone Protein1 3     Regenerating Islet-Derived 1 Alpha (Pancreatic Stone Protein, Pancreatic
Thread Protein)1
Islet Cells Regeneration Factor2 3     P192
Islet Of Langerhans Regenerating Protein2 3     Lithostathine 1 Alpha2
Regenerating Islet-Derived Protein 1-Alpha2 3     lithostathine-1-alpha2
Regenerating Protein I Alpha2 3     Pancreatic Stone Protein, Secretory2
ICRF2 3     protein-X2

External Ids:    HGNC: 99511   Entrez Gene: 59672   Ensembl: ENSG000001153867   OMIM: 1677705   UniProtKB: P054513   

Export aliases for REG1A gene to outside databases

Previous GC identifers: GC02P079485 GC02P079305 GC02P079322 GC02P079259 GC02P079201 GC02P079082


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for REG1A Gene:
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped
into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene
encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and
diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene
are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.
(provided by RefSeq, Jul 2008)

GeneCards Summary for REG1A Gene: 
REG1A (regenerating islet-derived 1 alpha) is a protein-coding gene. Diseases associated with REG1A include cerebral atherosclerosis, and pancreatitis. GO annotations related to this gene include carbohydrate binding and growth factor activity. An important paralog of this gene is REG3A.

UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with
neuronal sprouting in brain, and with brain and pancreas regeneration

Gene Wiki entry for REG1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REG1A gene promoter:
         AP-2rep   RP58   NF-1   GATA-3   CUTL1   NF-kappaB   STAT3   ZID   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREG1A promoter sequence
   Search SABiosciences Chromatin IP Primers for REG1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REG1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p12   HGNC cytogenetic band: 2p12

REG1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REG1A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P079347:  view genomic region     (about GC identifiers)

Start:
79,347,488 bp from pter      End:
79,350,545 bp from pter
Size:
3,058 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451 (See protein sequence)
Recommended Name: Lithostathine-1-alpha precursor  
Size: 166 amino acids; 18731 Da
Subcellular location: Secreted
Developmental stage: High expression levels in fetal and infant brains; much lower in adult brains
2 PDB 3D structures from and Proteopedia for REG1A:
1LIT (3D)        1QDD (3D)    
Secondary accessions: P11379 Q4ZG28

Explore the universe of human proteins at neXtProt for REG1A: NX_P05451

Explore proteomics data for REG1A at MOPED 

Post-translational modifications:

  • UniProtKB: The composition of the O-linked carbohydrate on Thr-27 is complex and varied. In the crystallographic structure,
    the attached sugar appears to be N-acetylglucosamine, typical of an intracellular protein, rather than
    N-acetylgalactosamine
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05451

  • REG1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    REG1A Protein Expression
    REFSEQ proteins: NP_002900.2  
    ENSEMBL proteins: 
     ENSP00000233735  

    Human Recombinant Protein Products for REG1A: 
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    Novus Biologicals REG1A Proteins
    Novus Biologicals REG1A Lysate
    Sino Biological Recombinant Protein for REG1A
    Sino Biological Cell Lysate for REG1A 
    ProSpec Recombinant Protein for REG1A
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    REG1A for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P05451

    ProtoNet protein and cluster: P05451

    2 Blocks protein domains:
    IPB002353 Type II antifreeze protein signature
    IPB003990 Pancreatitis-associated protein signature


    UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
    Similarity: Contains 1 C-type lectin domain


    REG1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REG1A_HUMAN, P05451
    Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with
    neuronal sprouting in brain, and with brain and pancreas regeneration

         Genatlas biochemistry entry for REG1A:
    regenerating gene,rat islet-derived homolog 1 alpha,expressed in kidney,stomach,pancreas,involved in beta cells
    proliferation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity IDA10526060
    GO:0030246carbohydrate binding IEA--
         
    REG1A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for REG1A:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Reg1):
     endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    REG1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Reg1tm1Okam for REG1A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for REG1A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for REG1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REG1A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REG1A 

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG1A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for REG1A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Type II interferon signaling (IFNG)
    Type II interferon signaling (IFNG)
    2Insulin Signaling
    Insulin Signaling


    2 BioSystems Pathways for REG1A
        Insulin Signaling
    Type II interferon signaling (IFNG)



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for REG1A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for REG1A (P054513 ENSP000002337354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    REG3AQ061413, ENSP000003043114I2D: score=1 STRING: ENSP00000304311
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation TAS2332435

    REG1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    REG1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REG1A

    1 HMDB Compound for REG1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for REG1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    O-Sialic Acid-- --target--17139284 17016423
    Phosphonoserine-- --target--10592235

    10 Novoseek inferred chemical compound relationships for REG1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium carbonate 61.1 7 8482198 (1), 8333731 (1), 9006958 (1), 1985964 (1) (see all 5)
    trypsinogen 49.9 1 11884767 (1)
    nicotinamide 36 1 8767167 (1)
    phosphoserine 34.7 3 11342136 (2), 14983068 (1)
    pyruvate 11.5 2 9067533 (1), 10590436 (1)
    genistein 8.41 1 16793699 (1)
    thymidine 1.13 3 8613011 (1), 9823399 (1)
    glucose 0 6 18953250 (4)
    tyrosine 0 3 8764975 (1), 19807095 (1)
    serine 0 2 11342136 (1)

    Search CenterWatch for drugs/clinical trials and news about REG1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for REG1A gene: 
    NM_002909.4  

    Unigene Cluster for REG1A:

    Regenerating islet-derived 1 alpha
    Hs.49407  [show with all ESTs]
    Unigene Representative Sequence: BI838728
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488524(uc010ffx.1) ENST00000233735(uc002snz.3 uc010ysd.2)
    ENST00000461579 ENST00000485184

    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REG1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REG1A
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REG1A

    Additional mRNA sequence: 

    AF172331.1 AK291981.1 AK307292.1 AK311087.1 BC005350.2 BC110438.2 BC118544.1 BC118621.1 
    M18963.1 

    24/25 DOTS entries (see all 25):

    DT.120961919  DT.97855959  DT.120961917  DT.95216056  DT.100794214  DT.95255502  DT.97855960  DT.120961900 
    DT.95216013  DT.100794207  DT.100033806  DT.100033807  DT.120961929  DT.219334  DT.120961860  DT.120961923 
    DT.120961931  DT.87008522  DT.95216000  DT.97855961  DT.97855965  DT.100794212  DT.120961901  DT.97855958 

    24/1321 AceView cDNA sequences (see all 1321):

    AA367280 AA366598 BQ084223 CA843095 BM353356 BU074714 CA951024 BM503467 
    BM313305 BQ417055 BM769754 BU952694 BM769769 BI712692 CA941561 BM825692 
    CA774498 BQ777793 CB177241 CA842098 BM819090 BM352982 BQ777062 BM310683 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for REG1A    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d
    SP1:                                                        -                           
    SP2:                                                        -     -                     
    SP3:                                -                       -                           
    SP4:                                                                                    
    SP5:                                -     -     -           -                           


    ECgene alternative splicing isoforms for REG1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REG1A expression in normal human tissues (normalized intensities)      REG1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCACTAT
    REG1A Expression
    About this image


    REG1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 6 entries
             small intestine ; glandular cells   
             small intestine   
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Duct Cells Pancreatic Ducts
             pancreas ; exocrine glandular cells   
             Pancreatic Islet   
     
     Stomach (Gastrointestinal Tract)
             stomach cardiac   
     
     Ovary (Reproductive System)
             oocyte   
     
     Colon (Gastrointestinal Tract)

    See REG1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REG1A

    SOURCE GeneReport for Unigene cluster: Hs.49407

    UniProtKB/Swiss-Prot: REG1A_HUMAN, P05451
    Tissue specificity: In pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related
    transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down
    syndrome patients

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REG1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for REG1A gene from 4/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Reg11 , 5 regenerating islet-derived 11, 5 79.3(n)1
    74.53(a)1
      6 (34.77 cM)5
    196921  NM_009042.11  NP_033068.11 
     784259835 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 10)
    Uncharacterized protein
    (see all 10)
    34(a)
    32(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    GL343442.1(588370-592837)
    GL343442.1(335200-340404)
    zebrafish
    (Danio rerio)
    Actinopterygii REG1A6
    si:dkey-9i23.56
    (see all 4)
    si:dkey-9i23.5
    (see all 4)
    22(a)
    15(a)
    (see all 4)
    1 ↔ many
    possible ortholog
    (see all 4)
    1(9070895-9076445)
    1(45236327-45239036)
    worm
    (Caenorhabditis elegans)
    Secernentea clec-1616
    Y38H6C.86
    (see all 3)
    Protein Y38H6C.8
    (see all 3)
    3(a)
    20(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(9603026-9608688)
    V(20514766-20515706)


    ENSEMBL Gene Tree for REG1A (if available)
    TreeFam Gene Tree for REG1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for REG1A gene
    REG3A2  REG42  REG3G2  REG1B2  
    18/22 SIMAP similar genes for REG1A using alignment to 2 protein entries:     REG1A_HUMAN (see all proteins) (see all similar genes):
    REG1B    PAP    REG3A    REG3G    REG4    KLRC2
    KLRC3    ACAN    CSPG3 variant protein    KLRC1    NCAN    ASGR2
    MRC2    FCER2    VCAN    DKFZp686K06110    CLEC17A    MRC1

    REG1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/167 SNPs in REG1A are shown (see all 167)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009693011,2
    Cuntested179213691(+) GAATTC/TGGGCA 2 S L mis10--------
    rs1889319401,2
    --79080899(+) TGAGGA/CAGGCA 1 -- us2k10--------
    rs19644751,2
    C,F--79210243(+) CCCAGG/CTACTC 1 -- us2k14Minor allele frequency- C:0.38NA 8
    rs1932473511,2
    --79210277(+) AATGGC/TGTGAA 1 -- us2k10--------
    rs1837147181,2
    --79210293(+) AAGGCA/GGAGCT 1 -- us2k10--------
    rs1135898841,2
    C,F--79210303(+) TTGCAG/ATGAGC 1 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs1882246391,2
    --79210308(+) GTGAGA/CTGAGA 1 -- us2k10--------
    rs2838851,2
    C,A--79210353(+) cagacA/Tccatc 1 -- us2k1 tfbs39Minor allele frequency- T:0.00NA WA CSA 16
    rs1807490801,2
    --79210404(+) AAAACA/GTTATG 1 -- us2k10--------
    rs101938471,2
    C--79210451(+) AATTGA/CTTGTT 1 -- us2k1 tfbs30--------

    HapMap Linkage Disequilibrium report for REG1A (79347488 - 79350545 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for REG1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2796CNV Loss18451855
    nsv522260CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 167770    OMIM disorders: --

    20/38 diseases for REG1A (see all 38):    About MalaCards
    cerebral atherosclerosis    pancreatitis    choledochal cyst    tropical calcific pancreatitis
    acinar cell carcinoma    pancreatic diseases    hereditary pancreatitis    acute pancreatitis
    gastric adenocarcinoma    esophageal cancer    liver cirrhosis    barrett's esophagus
    multiple endocrine neoplasia    primary biliary cirrhosis    seminoma    celiac disease
    pancreatic cancer    pituitary adenoma    ulcerative colitis    peritonitis

    1 disease from the University of Copenhagen DISEASES database for REG1A:
    Pancreatitis

    REG1A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/28 Novoseek inferred disease relationships for REG1A gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreas exocrine 71.8 6 8333731 (1), 7607222 (1), 8348956 (1), 8825811 (1) (see all 5)
    chronic pancreatitis 68.2 14 1698685 (2), 7716137 (2), 8482198 (1), 11249074 (1) (see all 11)
    carcinoma acinar cell 65.9 1 1525759 (1)
    pancreatic diseases 54.6 2 19325491 (1), 1698685 (1)
    pancreatitis hereditary 54.3 7 1578808 (3)
    pancreatitis 53.1 15 11884767 (2), 16360171 (2), 8482198 (1), 18953250 (1) (see all 8)
    acute pancreatitis 42.2 5 8501356 (2)
    paired helical filament 39.7 3 2394826 (1), 10329440 (1)
    calculi 38.4 1 11884767 (1)
    colorectal tumors 38 3 9834348 (1), 12455032 (1)

    Genetic Association Database (GAD): REG1A
    Human Genome Epidemiology (HuGE) Navigator: REG1A (4 documents)

    Export disorders for REG1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REG1A gene, integrated from 9 sources (see all 160):
    (articles sorted by number of sources associating them with REG1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. (PubMed id 2332435)1, 2, 3, 9 Watanabe T.... Okamoto H. (1990)
    2. Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain. (PubMed id 2394826)1, 2, 9 de la Monte S.M.... Wands J.R. (1990)
    3. Human regeneration protein/lithostathine genes map to chromosome 2p12. (PubMed id 8333731)1, 3, 9 Gharib B....Berge-lefranc J.L. (1993)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis. (PubMed id 17990360)1, 4 Mahurkar S....Chandak G.R. (2007)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. No abnormalities of reg1 alpha and reg1 beta gene associated with diabetes mellitus. (PubMed id 11796176)1, 4 Banchuin N....Yenchitsomanus P.T. (2002)
    9. Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine. (PubMed id 10625646)1, 2 Gerbaud V.... Verdier J.-M. (2000)
    10. Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation. (PubMed id 8654365)1, 2 Bertrand J.A....Fontecilla-Camps J.-C. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5967 HGNC: 9951 AceView: REG1A Ensembl:ENSG00000115386 euGenes: HUgn5967
    ECgene: REG1A H-InvDB: REG1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REG1A Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_254

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for REG1A gene:
    Search GeneIP for patents involving REG1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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