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Aliases for REEP6 Gene

Aliases for REEP6 Gene

  • Receptor Accessory Protein 6 2 3
  • Polyposis Locus Protein 1-Like 1 2 3 4
  • C19orf32 3 4 6
  • DP1L1 3 4 6
  • Deleted In Polyposis 1-Like 1 2 3
  • TB2L1 3 6
  • Receptor Expression Enhancing Protein 6 3
  • Receptor Expression-Enhancing Protein 6 3
  • Chromosome 19 Open Reading Frame 32 2

External Ids for REEP6 Gene

Previous Symbols for REEP6 Gene

  • C19orf32

Summaries for REEP6 Gene

GeneCards Summary for REEP6 Gene

REEP6 (Receptor Accessory Protein 6) is a Protein Coding gene. An important paralog of this gene is REEP2.

UniProtKB/Swiss-Prot for REEP6 Gene

  • May play a role in intracellular protein transport from the endoplasmic reticulum to the cell surface. May play a role in retinal development (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REEP6 Gene

Genomics for REEP6 Gene

Genomic Location for REEP6 Gene

Start:
1,490,747 bp from pter
End:
1,497,927 bp from pter
Size:
7,181 bases
Orientation:
Plus strand

Genomic View for REEP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REEP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REEP6 Gene

Regulatory Elements for REEP6 Gene

Proteins for REEP6 Gene

  • Protein details for REEP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HR9-REEP6_HUMAN
    Recommended name:
    Receptor expression-enhancing protein 6
    Protein Accession:
    Q96HR9
    Secondary Accessions:
    • B2RE01
    • D6W5Z0
    • Q96LM0

    Protein attributes for REEP6 Gene

    Size:
    184 amino acids
    Molecular mass:
    20733 Da
    Quaternary structure:
    No Data Available

neXtProt entry for REEP6 Gene

Proteomics data for REEP6 Gene at MOPED

Post-translational modifications for REEP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REEP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for REEP6 Gene

Domains for REEP6 Gene

Gene Families for REEP6 Gene

HGNC:
  • REEP :Receptor accessory proteins

Protein Domains for REEP6 Gene

UniProtKB/Swiss-Prot:

REEP6_HUMAN
Family:
  • Belongs to the DP1 family.:
    • Q96HR9
genes like me logo Genes that share domains with REEP6: view

Function for REEP6 Gene

Molecular function for REEP6 Gene

UniProtKB/Swiss-Prot Function: May play a role in intracellular protein transport from the endoplasmic reticulum to the cell surface. May play a role in retinal development (By similarity).

Gene Ontology (GO) - Molecular Function for REEP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with REEP6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for REEP6 Gene

Localization for REEP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REEP6 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REEP6 Gene COMPARTMENTS Subcellular localization image for REEP6 gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for REEP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0044317 rod spherule IEA --
GO:0045177 apical part of cell IEA --
genes like me logo Genes that share ontologies with REEP6: view

Pathways for REEP6 Gene

SuperPathways for REEP6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REEP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0032386 regulation of intracellular transport IEA --
genes like me logo Genes that share ontologies with REEP6: view

No data available for Pathways by source for REEP6 Gene

Transcripts for REEP6 Gene

mRNA/cDNA for REEP6 Gene

Unigene Clusters for REEP6 Gene

Receptor accessory protein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for REEP6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: -
SP3:

Relevant External Links for REEP6 Gene

GeneLoc Exon Structure for
REEP6
ECgene alternative splicing isoforms for
REEP6

Expression for REEP6 Gene

mRNA expression in normal human tissues for REEP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REEP6 Gene

This gene is overexpressed in Liver (15.6), Testis (13.3), and Adrenal Gland (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for REEP6 Gene

SOURCE GeneReport for Unigene cluster for REEP6 Gene Hs.76277

genes like me logo Genes that share expressions with REEP6: view

Orthologs for REEP6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REEP6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia REEP6 36
  • 83.33 (n)
  • 80.56 (a)
REEP6 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia REEP6 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Reep6 36
  • 80.29 (n)
  • 80.11 (a)
Reep6 16
Reep6 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia REEP6 37
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia REEP6 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Reep6 36
  • 83.04 (n)
  • 81.5 (a)
chicken
(Gallus gallus)
Aves REEP6 36
  • 69.05 (n)
  • 65.71 (a)
REEP6 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia reep6 36
  • 62.43 (n)
  • 60.12 (a)
zebrafish
(Danio rerio)
Actinopterygii reep6 36
  • 61.96 (n)
  • 60.59 (a)
reep6 37
  • 50 (a)
OneToMany
reep6 37
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4960 37
  • 40 (a)
ManyToMany
CG8331 37
  • 46 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea yop-1 37
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOP1 37
  • 32 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3091 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11316 37
  • 44 (a)
OneToMany
Species with no ortholog for REEP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REEP6 Gene

ENSEMBL:
Gene Tree for REEP6 (if available)
TreeFam:
Gene Tree for REEP6 (if available)

Paralogs for REEP6 Gene

Paralogs for REEP6 Gene

Selected SIMAP similar genes for REEP6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with REEP6: view

Variants for REEP6 Gene

Sequence variations from dbSNP and Humsavar for REEP6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs791474 -- 1,493,044(+) CAGGG(G/T)CTGCC intron-variant
rs1050017 -- 1,497,544(+) CCTCC(A/G)GCCCC utr-variant-3-prime
rs1050018 -- 1,497,717(+) CAGCG(A/C)CAGAA utr-variant-3-prime
rs1050019 -- 1,497,725(+) GAAGG(A/G)ATCGT utr-variant-3-prime
rs2244686 -- 1,496,264(-) GGAGT(C/T)ACACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REEP6 Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv1055e1 CNV Complex 17122850
dgv3580n71 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3596n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
dgv3598n71 CNV Loss 21882294
nsv910491 CNV Gain+Loss 21882294
dgv3599n71 CNV Loss 21882294
essv18235 CNV CNV 17122850
nsv833705 CNV Loss 17160897
nsv910499 CNV Loss 21882294
dgv3600n71 CNV Loss 21882294
dgv3601n71 CNV Loss 21882294
dgv3602n71 CNV Loss 21882294
nsv910507 CNV Loss 21882294
dgv3603n71 CNV Loss 21882294
nsv470105 CNV Gain 18288195
dgv3604n71 CNV Gain+Loss 21882294
nsv910517 CNV Loss 21882294
nsv470106 CNV Loss 18288195
nsv910520 CNV Loss 21882294
esv2717844 CNV Deletion 23290073
nsv910521 CNV Loss 21882294

Relevant External Links for REEP6 Gene

HapMap Linkage Disequilibrium report
REEP6

Disorders for REEP6 Gene

Relevant External Links for REEP6

Genetic Association Database (GAD)
REEP6
Human Genome Epidemiology (HuGE) Navigator
REEP6
genes like me logo Genes that share disorders with REEP6: view

No data available for UniProtKB/Swiss-Prot for REEP6 Gene

Publications for REEP6 Gene

  1. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H. … Matsunami H. (Cell 2004) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark A.J. … Huebner A. (Trends Endocrinol. Metab. 2005) 2 3
  5. Polymorphisms of the apoptosis-associated gene DP1L1 (deleted in polyposis 1-like 1) in colon cancer and inflammatory bowel disease. (PMID: 19924442) Wellmann A. … Brinkmann U. (J. Cancer Res. Clin. Oncol. 2010) 3 49

Products for REEP6 Gene

Sources for REEP6 Gene

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