REEP6 Gene
protein-coding GIFtS : 50
GCID: GC19 P001491
receptor accessory protein 6 (Previous name: chromosome 19 open reading frame 32 ) (Previous symbol: C19orf32 )
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Aliasesfor REEP6 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Receptor Accessory Protein 6 1 2 FLJ253831 C19orf321 2 3 5 Chromosome 19 Open Reading Frame 321 DP1L11 2 3 5 Deleted In Polyposis 1-Like 12 Polyposis Locus Protein 1-Like 12 3 Receptor Expression Enhancing Protein 62 TB2L12 5 Receptor Expression-Enhancing Protein 62
Export aliases for REEP6 gene to outside databases Previous GC identifers: GC19P001444 GC19P001265
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Summariesfor REEP6 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: REEP6_HUMAN, Q96HR9 Function : May enhance the cell surface expression of odorant receptors (By similarity)
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Genomic Viewsfor REEP6 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011255.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the REEP6 gene promoter: Spz1 AML1a SREBP-1c LUN-1 E47 SREBP-1b YY1 Max SREBP-1a c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for REEP6 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat REEP6
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3 REEP6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P001491: view genomic region
(about GC identifiers )
Start:
1,491,165 bp from pter
End:
1,497,926 bp from pter
Size:
6,762 bases
Orientation:
plus strand
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Proteinsfor REEP6 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: REEP6_HUMAN, Q96HR9 (See
protein sequence )Recommended Name: Receptor expression-enhancing protein 6 Size : 184 amino acids; 20733 Da
Subunit : Interacts with odorant receptor proteins (By similarity)
Subcellular location : Membrane; Multi-pass membrane protein (By similarity)
Secondary accessions : B2RE01 D6W5Z0 Q96LM0Explore the universe of human proteins at neXtProt for REEP6: NX_Q96HR9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96HR9 REEP6 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_612402.1 ENSEMBL proteins: ENSP00000233596 ENSP00000378861 ENSP00000378865 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
REEP6 for ontologies About GeneDecksing REEP6 Antibody Products: Assay Products for REEP6:
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Protein
Domains / Familiesfor REEP6 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
REEP6 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q96HR9 ProtoNet protein and cluster: Q96HR9
1 Blocks protein family : IPB004345 TB2/DP1 and HVA22 related proteins UniProtKB/Swiss-Prot: REEP6_HUMAN, Q96HR9 Similarity : Belongs to the DP1 family
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Functionfor REEP6 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: REEP6_HUMAN, Q96HR9 Function : May enhance the cell surface expression of odorant receptors (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for REEP6 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for REEP6OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: REEP6 (NM_138393 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for REEP6 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat REEP6
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP6
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
-- --
REEP6 for ontologies About GeneDecksing
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Pathways & Interactionsfor REEP6 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for REEP6 STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)5 Interacting proteins for REEP6 (Q96HR9 2 , 3 ENSP00000233596 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor REEP6 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for REEP6 Search CenterWatch for drugs/clinical trials and news about REEP6
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Transcriptsfor REEP6 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for REEP6 gene: NM_138393.1 Unigene Cluster for REEP6:
Receptor accessory protein 6 Hs.744099 [show with all ESTs ] Unigene Representative Sequence: BC008201 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000233596 ENST00000591735 ENST00000395479 (uc010xgp.2 ) ENST00000395484 (uc002ltc.3 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for REEP6 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for REEP6OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: REEP6 (NM_138393 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for REEP6 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat REEP6
Additional cDNA sequence: AK058112.1 AK293919.1 AK315744.1 AY562244.1 BC008201.1
4 DOTS entries : DT.208109 DT.100035675
DT.92380570 DT.121497128 24/106 AceView cDNA sequences (see all 106 ):
AL044973 BQ635925 BI759723 BM695570 BI085472 BQ640333 BU176726 BX107670 AX775999 BC008201 BG385509 BG831262 AK058112 BQ962574 BE255249 BE255972 BQ027286 BM795564 BE901699 BQ894791 D12147 BQ637338 BG489703 BM554206 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for REEP6 About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b SP1 :           -           SP2 :               -       SP3 :                    
ECgene alternative splicing isoforms for REEP6
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Expression for REEP6 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section REEP6 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTCCAGTCTC
About this image REEP6 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See REEP6 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for REEP6 SOURCE GeneReport for Unigene cluster: Hs.744099 SABiosciences Custom PCR Arrays for REEP6 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for REEP6Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat REEP6 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat REEP6 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat REEP6 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP6
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Orthologsfor REEP6 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for REEP6 gene from 7/29 species (see all 29 ) About this table
ENSEMBL Gene Tree for REEP6 (if available)TreeFam Gene Tree for REEP6 (if available)
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Paralogsfor REEP6 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for REEP6 gene REEP1 2 REEP4 2 REEP3 2 REEP5 2 REEP2 2 4 SIMAP similar genes for REEP6 using alignment to 3 protein entries: REEP6_HUMAN (see all proteins ):REEP5 REEP2 REEP1 REEP4
REEP6 for paralogs About GeneDecksing
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Genomic Variantsfor REEP6 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 19 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for REEP6 (1491165 - 1497926 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for REEP6 4 CNVs : 7191 4066 30059 5066
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing REEP6
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Disorders
/ Diseasesfor REEP6 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
REEP6 for disorders About GeneDecksing
OMIM gene information: 609346
OMIM disorders : --5 diseases for REEP6 : About MalaCards polyposis peutz-jeghers syndrome inflammatory bowel disease colon cancer malaria Human Genome Epidemiology (HuGE) Navigator: REEP6 (4 documents) Export disorders for REEP6 gene to outside databases
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Publicationsfor REEP6 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for REEP6 gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with REEP6) Utopia : connect your pdf to the dynamic world of online information
RTP family members induce functional expression of mammalian odorant receptors. (PubMed id 15550249) 1 , 2 , 3 Saito H....Matsunami H. (2004) Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PubMed id 16271481) 1 , 3 Clark A.J....Huebner A. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086) 1 Bailey S.D....Anand S. (2010) Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121) 1 Talmud P.J.... . (2009) Polymorphisms of the apoptosis-associated gene DP1L1 (deleted in polyposis 1-like 1) in colon cancer and inflammatory bowel disease. (PubMed id 19924442) 1 Wellmann A....Brinkmann U. (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005)
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External Searches for REEP6 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing REEP6 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing REEP6 gene
(According to HUGE )
About This Section --
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Specialized Databases showing REEP6 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for REEP6 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for REEP6 gene: Search GeneIP for patents involving REEP6 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor REEP6 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for REEP6 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for REEP6 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for REEP6 OriGene Protein Over-expression Lysate for REEP6 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for REEP6 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for REEP6 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for REEP6 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for REEP6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for REEP6 OriGene Custom Protein Services for REEP6 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat REEP6 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing REEP6 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat REEP6 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat REEP6 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat REEP6 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat REEP6
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REEP6 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP6
ThermoFisher Antibodies for REEP6
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat REEP6
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