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REEP6 Gene

protein-coding   GIFtS: 51
GCID: GC19P001491

Receptor Accessory Protein 6

(Previous name: chromosome 19 open reading frame 32)
(Previous symbol: C19orf32)
  Search for REEP6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Receptor Accessory Protein 61 2     TB2L12 5
C19orf321 2 3 5     Chromosome 19 Open Reading Frame 321
Polyposis Locus Protein 1-Like 11 2 3     Receptor Expression Enhancing Protein 62
DP1L12 3 5     Receptor Expression-Enhancing Protein 62
Deleted In Polyposis 1-Like 11 2     

External Ids:    HGNC: 300781   Entrez Gene: 928402   Ensembl: ENSG000001152557   OMIM: 6093465   UniProtKB: Q96HR93   

Export aliases for REEP6 gene to outside databases

Previous GC identifers: GC19P001444 GC19P001265


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for REEP6 Gene:
REEP6 (receptor accessory protein 6) is a protein-coding gene. An important paralog of this gene is REEP4.

UniProtKB/Swiss-Prot: REEP6_HUMAN, Q96HR9
Function: May enhance the cell surface expression of odorant receptors (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the REEP6 gene promoter:
         Spz1   AML1a   SREBP-1c   LUN-1   E47   SREBP-1b   YY1   Max   SREBP-1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREEP6 promoter sequence
   Search Chromatin IP Primers for REEP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REEP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

REEP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REEP6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001491:  view genomic region     (about GC identifiers)

Start:
1,491,165 bp from pter      End:
1,497,926 bp from pter
Size:
6,762 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: REEP6_HUMAN, Q96HR9 (See protein sequence)
Recommended Name: Receptor expression-enhancing protein 6  
Size: 184 amino acids; 20733 Da
Subunit: Interacts with odorant receptor proteins (By similarity)
Secondary accessions: B2RE01 D6W5Z0 Q96LM0

Explore the universe of human proteins at neXtProt for REEP6: NX_Q96HR9

Explore proteomics data for REEP6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See REEP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612402.1  
    ENSEMBL proteins: 
     ENSP00000233596   ENSP00000378861   ENSP00000378865  

    REEP6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for REEP6

     
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    REEP6 Antibody Products:

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    ThermoFisher Antibodies for REEP6
    LSBio Antibodies in human, mouse, rat for REEP6

    REEP6 Assay Products:

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    Cloud-Clone Corp. ELISAs for REEP6
    Cloud-Clone Corp. CLIAs for REEP6
    Search eBioscience for ELISAs for REEP6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    REEP: Receptor accessory proteins

    1 InterPro protein domain:
     IPR004345 TB2_DP1_HVA22

    Graphical View of Domain Structure for InterPro Entry Q96HR9

    ProtoNet protein and cluster: Q96HR9

    1 Blocks protein domain: IPB004345 TB2/DP1 and HVA22 related proteins

    UniProtKB/Swiss-Prot: REEP6_HUMAN, Q96HR9
    Similarity: Belongs to the DP1 family


    Find genes that share domains with REEP6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REEP6_HUMAN, Q96HR9
    Function: May enhance the cell surface expression of odorant receptors (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with REEP6           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for REEP6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for REEP6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REEP6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REEP6

    miRNA
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    Block miRNA regulation of human, mouse, rat REEP6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate REEP6:
    hsa-miR-125a-3p
    SwitchGear 3'UTR luciferase reporter plasmidREEP6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for REEP6
    Predesigned siRNA for gene silencing in human, mouse, rat REEP6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for REEP6

    Clone
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    OriGene clones in human, mouse for REEP6 (see all 7)
    OriGene ORF clones in mouse, rat for REEP6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REEP6 (NM_138393)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REEP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP6

    Cell Line
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    REEP6_HUMAN, Q96HR9: Membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane2
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with REEP6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for REEP6
    Interactions:

        Search GeneGlobe Interaction Network for REEP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for REEP6 (Q96HR92, 3 ENSP000002335964) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM160A2Q8N6122, 3, ENSP000002659784MINT-67761 I2D: score=5 STRING: ENSP00000265978
    YWHAZP631042, 3, ENSP000003095034MINT-3307638 I2D: score=1 STRING: ENSP00000309503
    SNX15Q9NRS63I2D: score=1 
    TMEM33ENSP000002644524STRING: ENSP00000264452
    KIAA1715ENSP000002727484STRING: ENSP00000272748
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for REEP6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for REEP6 gene: 
    NM_138393.1  

    Unigene Cluster for REEP6:

    Receptor accessory protein 6
    Hs.76277  [show with all ESTs]
    Unigene Representative Sequence: BC008201
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233596 ENST00000591735 ENST00000395479(uc010xgp.2) ENST00000395484(uc002ltc.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat REEP6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate REEP6:
    hsa-miR-125a-3p
    SwitchGear 3'UTR luciferase reporter plasmidREEP6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for REEP6
    Predesigned siRNA for gene silencing in human, mouse, rat REEP6
    Clone
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    OriGene clones in human, mouse for REEP6 (see all 7)
    OriGene ORF clones in mouse, rat for REEP6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REEP6 (NM_138393)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REEP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for REEP6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REEP6
      QuantiTect SYBR Green Assays in human, mouse, rat REEP6
      QuantiFast Probe-based Assays in human, mouse, rat REEP6

    Additional mRNA sequence: 

    AK058112.1 AK293919.1 AK315744.1 AY562244.1 BC008201.1 

    4 DOTS entries:

    DT.208109  DT.100035675  DT.92380570  DT.121497128 

    Selected AceView cDNA sequences (see all 106):

    BM795564 BE255972 BQ962574 BX107670 BC008201 AK058112 BI759723 BU176726 
    BQ894791 BQ635925 BE901699 BG489703 AL045115 BQ637338 BE255249 BM554206 
    BQ027286 AL044973 BG831262 D12147 BI085472 AX775999 NM_138393 BQ640333 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for REEP6    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                                -                           
    SP2:                                            -               
    SP3:                                                            


    ECgene alternative splicing isoforms for REEP6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    REEP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCAGTCTC
    REEP6 Expression
    About this image


    REEP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
    REEP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REEP6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.76277
        Custom PCR Arrays for REEP6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for REEP6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Reep61 , 5 receptor accessory protein 61, 5 80.29(n)1
    80.11(a)1
      10 (39.72 cM)5
    703351  NM_139292.21  NP_647453.11 
     803299535 
    chicken
    (Gallus gallus)
    Aves REEP61 receptor accessory protein 6 69.05(n)
    65.71(a)
      427265  XM_424848.4  XP_424848.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia reep61 receptor accessory protein 6 62.43(n)
    60.12(a)
      548805  NM_001016051.2  NP_001016051.1 
    zebrafish
    (Danio rerio)
    Actinopterygii reep61 receptor accessory protein 6 61.96(n)
    60.59(a)
      447918  NM_001004656.1  NP_001004656.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG83316
    CG49606
    --
    46(a)
    40(a)
    many ↔ many
    many ↔ many
    2R(10057971-10060503)
    3R(21612256-21613020)
    worm
    (Caenorhabditis elegans)
    Secernentea yop-16
    Protein YOP-1 (yop-1) mRNA, complete cds
    42(a)
    1 → many
    I(2730004-2731454) WBGene00022127
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YOP16
    Membrane protein that interacts with Yip1p to medi...
    32(a)
    1 → many
    XVI(623527-624202) YPR028W


    ENSEMBL Gene Tree for REEP6 (if available)
    TreeFam Gene Tree for REEP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for REEP6 gene
    REEP42  REEP12  REEP32  REEP52  REEP22  
    4 SIMAP similar genes for REEP6 using alignment to 3 protein entries:     REEP6_HUMAN (see all proteins):
    REEP5    REEP2    REEP1    REEP4

    Find genes that share paralogs with REEP6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for REEP6 (see all 223)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1499742791,2
    C--1492472(+) ACTATG/TTTACC 1 -- int10--------
    rs1807721921,2
    --1492507(+) TCAAGC/TGATCC 1 -- int10--------
    rs1173901121,2
    C,F--1492621(+) TCTTCC/TAGGAA 1 -- int11Minor allele frequency- T:0.03EA 120
    rs739209551,2
    C,F--1492651(+) AAGGAC/TTTGCT 1 -- int12Minor allele frequency- T:0.06WA 120
    rs1452753701,2
    --1492663(+) TGGGCC/TTGGGG 1 -- int10--------
    rs1130785451,2
    C--1492735(+) CAGTT-/CC/CCC
            
    CCCCC
    2 -- int1 cds11CSA 2
    rs572699101,2
    C--1492742(+) CCCCC-/CC/CCC
            
    AATTT
    2 -- int1 cds10--------
    rs1158078741,2
    F--1492825(+) CCCCAG/AGTGCC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1843567541,2
    --1492829(+) AGGTGC/TCTGGT 1 -- int10--------
    rs341578701,2
    C,F--1492845(+) GTGCAG/ACGCAG 1 -- int14Minor allele frequency- A:0.04NA 126

    HapMap Linkage Disequilibrium report for REEP6 (1491165 - 1497926 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for REEP6 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717844CNV Deletion23290073
    dgv3589n71CNV Loss21882294
    nsv470106CNV Loss18288195
    nsv910292CNV Loss21882294
    nsv910499CNV Loss21882294
    nsv910520CNV Loss21882294
    nsv910517CNV Loss21882294
    dgv3596n71CNV Loss21882294
    dgv3601n71CNV Loss21882294
    nsv910507CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing REEP6
    DNA2.0 Custom Variant and Variant Library Synthesis for REEP6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609346    OMIM disorders: --


    Find genes that share disorders with REEP6           About GenesLikeMe

    Genetic Association Database (GAD): REEP6
    Human Genome Epidemiology (HuGE) Navigator: REEP6 (4 documents)

    Export disorders for REEP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for REEP6 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with REEP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RTP family members induce functional expression of mammalian odorant receptors. (PubMed id 15550249)1, 2, 3 Saito H.... Matsunami H. (Cell 2004)
    2. Polymorphisms of the apoptosis-associated gene DP1L1 (deleted in polyposis 1-like 1) in colon cancer and inflammatory bowel disease. (PubMed id 19924442)1, 4 Wellmann A....Brinkmann U. (J. Cancer Res. Clin. Oncol. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PubMed id 16271481)1, 3 Clark A.J....Huebner A. (Trends Endocrinol. Metab. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92840 HGNC: 30078 AceView: C19orf32 Ensembl:ENSG00000115255 euGenes: HUgn92840
    ECgene: REEP6 H-InvDB: REEP6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for REEP6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for REEP6 gene:
    Search GeneIP for patents involving REEP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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