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Aliases for REEP5 Gene

Aliases for REEP5 Gene

  • Receptor Accessory Protein 5 2 3 5
  • Polyposis Locus Protein 1 2 3 4
  • Polyposis Coli Region Hypothetical Protein DP1 2 3
  • Deleted In Polyposis 1 2 3
  • C5orf18 3 4
  • DP1 3 4
  • TB2 3 4
  • Receptor Expression Enhancing Protein 5 3
  • Chromosome 5 Open Reading Frame 18 2
  • Protein TB2 4
  • D5S346 3
  • Yip2e 3
  • YOP1 3

External Ids for REEP5 Gene

Previous HGNC Symbols for REEP5 Gene

  • C5orf18

Previous GeneCards Identifiers for REEP5 Gene

  • GC05M112240
  • GC05M112212
  • GC05M107391

Summaries for REEP5 Gene

GeneCards Summary for REEP5 Gene

REEP5 (Receptor Accessory Protein 5) is a Protein Coding gene. Diseases associated with REEP5 include familial adenomatous polyposis. An important paralog of this gene is REEP6.

UniProtKB/Swiss-Prot for REEP5 Gene

  • May promote functional cell surface expression of olfactory receptors.

Gene Wiki entry for REEP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REEP5 Gene

Genomics for REEP5 Gene

Regulatory Elements for REEP5 Gene

Promoters for REEP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around REEP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for REEP5 Gene

Chromosome:
5
Start:
112,876,379 bp from pter
End:
112,922,539 bp from pter
Size:
46,161 bases
Orientation:
Minus strand

Genomic View for REEP5 Gene

Genes around REEP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REEP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REEP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REEP5 Gene

Proteins for REEP5 Gene

  • Protein details for REEP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00765-REEP5_HUMAN
    Recommended name:
    Receptor expression-enhancing protein 5
    Protein Accession:
    Q00765
    Secondary Accessions:
    • B7Z681
    • D3DT04
    • Q04198
    • Q5QGT0
    • Q9BWH9

    Protein attributes for REEP5 Gene

    Size:
    189 amino acids
    Molecular mass:
    21493 Da
    Quaternary structure:
    • Interacts with ATL1 (By similarity). Interacts with ATL2.
    SequenceCaution:
    • Sequence=AAA60136.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA66351.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH65926.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for REEP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REEP5 Gene

Proteomics data for REEP5 Gene at MOPED

Post-translational modifications for REEP5 Gene

  • Ubiquitination at Lys 16, Lys 147, and Lys 157
  • Modification sites at PhosphoSitePlus

Other Protein References for REEP5 Gene

No data available for DME Specific Peptides for REEP5 Gene

Domains & Families for REEP5 Gene

Gene Families for REEP5 Gene

Protein Domains for REEP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q00765

UniProtKB/Swiss-Prot:

REEP5_HUMAN :
  • Belongs to the DP1 family.
Family:
  • Belongs to the DP1 family.
genes like me logo Genes that share domains with REEP5: view

Function for REEP5 Gene

Molecular function for REEP5 Gene

UniProtKB/Swiss-Prot Function:
May promote functional cell surface expression of olfactory receptors.

Gene Ontology (GO) - Molecular Function for REEP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with REEP5: view
genes like me logo Genes that share phenotypes with REEP5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for REEP5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REEP5 Gene

Localization for REEP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REEP5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REEP5 Gene COMPARTMENTS Subcellular localization image for REEP5 gene
Compartment Confidence
extracellular 5
cytosol 3
endoplasmic reticulum 2
nucleus 2
cytoskeleton 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for REEP5 Gene

Pathways & Interactions for REEP5 Gene

SuperPathways for REEP5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REEP5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for REEP5 Gene

Drugs & Compounds for REEP5 Gene

(4) Drugs for REEP5 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 494
Fluoxetine Approved Pharma Channel blocker 229
Paroxetine Approved, Investigational Pharma Inhibition, Inhibitor 221
Sertraline Approved Pharma Inhibition, Inhibitor 282
genes like me logo Genes that share compounds with REEP5: view

Transcripts for REEP5 Gene

Unigene Clusters for REEP5 Gene

Receptor accessory protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for REEP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4:
SP5: -

Relevant External Links for REEP5 Gene

GeneLoc Exon Structure for
REEP5
ECgene alternative splicing isoforms for
REEP5

Expression for REEP5 Gene

mRNA expression in normal human tissues for REEP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for REEP5 Gene

This gene is overexpressed in Nasal epithelium (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for REEP5 Gene



SOURCE GeneReport for Unigene cluster for REEP5 Gene Hs.429608

mRNA Expression by UniProt/SwissProt for REEP5 Gene

Q00765-REEP5_HUMAN
Tissue specificity: Expressed in circumvallate papillae and testis.
genes like me logo Genes that share expression patterns with REEP5: view

Protein tissue co-expression partners for REEP5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for REEP5 Gene

Orthologs for REEP5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REEP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REEP5 35
  • 99.82 (n)
  • 100 (a)
REEP5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia REEP5 36
  • 90 (a)
OneToOne
REEP5 35
  • 89.77 (n)
  • 90.48 (a)
dog
(Canis familiaris)
Mammalia LOC479137 35
  • 89.25 (n)
  • 86.29 (a)
REEP5 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Reep5 16
Reep5 35
  • 90.48 (n)
  • 93.65 (a)
Reep5 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia REEP5 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia REEP5 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Reep5 35
  • 88.89 (n)
  • 94.18 (a)
chicken
(Gallus gallus)
Aves REEP5 36
  • 85 (a)
OneToOne
REEP5 35
  • 80.78 (n)
  • 85.19 (a)
lizard
(Anolis carolinensis)
Reptilia REEP5 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia reep5 35
  • 74.96 (n)
  • 77.78 (a)
Str.6213 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8928 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
reep5 35
  • 71.12 (n)
  • 72.73 (a)
reep5 36
  • 72 (a)
OneToMany
reep5 36
  • 72 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004819 35
  • 55.49 (n)
  • 49.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4960 36
  • 41 (a)
ManyToMany
CG8331 36
  • 43 (a)
ManyToMany
CG8331 35
  • 58.8 (n)
  • 52.78 (a)
worm
(Caenorhabditis elegans)
Secernentea yop-1 36
  • 43 (a)
OneToMany
yop-1 35
  • 53.33 (n)
  • 47.88 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR063W 35
  • 45.9 (n)
  • 32.57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOP1 35
  • 46.09 (n)
  • 38.26 (a)
YOP1 36
  • 32 (a)
OneToMany
YOP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06601g 35
  • 46.93 (n)
  • 40.13 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06702 35
  • 55.06 (n)
  • 45.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes yop1 35
  • 50.97 (n)
  • 40.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11316 36
  • 48 (a)
OneToMany
Species with no ortholog for REEP5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REEP5 Gene

ENSEMBL:
Gene Tree for REEP5 (if available)
TreeFam:
Gene Tree for REEP5 (if available)

Paralogs for REEP5 Gene

Paralogs for REEP5 Gene

(4) SIMAP similar genes for REEP5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with REEP5: view

Variants for REEP5 Gene

Sequence variations from dbSNP and Humsavar for REEP5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs149192 -- 112,916,369(-) GCAGC(A/G)TTGCC intron-variant
rs153545 -- 112,903,185(-) AGAAA(A/G)TTATT intron-variant
rs153546 -- 112,902,342(-) CTCAG(G/T)ACCTG intron-variant
rs153547 -- 112,902,220(-) acaaa(A/C)aaaaa intron-variant
rs153548 -- 112,902,027(-) TCTGG(G/T)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REEP5 Gene

Variant ID Type Subtype PubMed ID
nsv4960 CNV Loss 18451855
esv26872 CNV Loss 19812545
esv2730601 CNV Deletion 23290073
esv2667456 CNV Deletion 23128226

Variation tolerance for REEP5 Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REEP5 Gene

HapMap Linkage Disequilibrium report
REEP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REEP5 Gene

Disorders for REEP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for REEP5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
familial adenomatous polyposis
  • adenomatous polyposis coli
- elite association - COSMIC cancer census association via MalaCards
Search REEP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for REEP5

Genetic Association Database (GAD)
REEP5
Human Genome Epidemiology (HuGE) Navigator
REEP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REEP5
genes like me logo Genes that share disorders with REEP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REEP5 Gene

Publications for REEP5 Gene

  1. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H. … Matsunami H. (Cell 2004) 2 3 4 67
  2. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark A.J. … Huebner A. (Trends Endocrinol. Metab. 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PMID: 22379092) Shamay M. … Hayward S.D. (J. Virol. 2012) 3

Products for REEP5 Gene

Sources for REEP5 Gene

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