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Aliases for REEP5 Gene

Aliases for REEP5 Gene

  • Receptor Accessory Protein 5 2 3
  • Polyposis Locus Protein 1 2 3 4
  • C5orf18 3 4 6
  • DP1 3 4 6
  • Polyposis Coli Region Hypothetical Protein DP1 2 3
  • Deleted In Polyposis 1 2 3
  • D5S346 3 6
  • TB2 3 4
  • Receptor Expression Enhancing Protein 5 3
  • Receptor Expression-Enhancing Protein 5 3
  • Chromosome 5 Open Reading Frame 18 2
  • Protein TB2 4
  • YOP1 3

External Ids for REEP5 Gene

Previous HGNC Symbols for REEP5 Gene

  • C5orf18

Previous GeneCards Identifiers for REEP5 Gene

  • GC05M112240
  • GC05M112212
  • GC05M107391

Summaries for REEP5 Gene

GeneCards Summary for REEP5 Gene

REEP5 (Receptor Accessory Protein 5) is a Protein Coding gene. An important paralog of this gene is REEP2.

UniProtKB/Swiss-Prot for REEP5 Gene

  • May promote functional cell surface expression of olfactory receptors

Gene Wiki entry for REEP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REEP5 Gene

Genomics for REEP5 Gene

Regulatory Elements for REEP5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for REEP5 Gene

112,876,379 bp from pter
112,922,539 bp from pter
46,161 bases
Minus strand

Genomic View for REEP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REEP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REEP5 Gene

Proteins for REEP5 Gene

  • Protein details for REEP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor expression-enhancing protein 5
    Protein Accession:
    Secondary Accessions:
    • B7Z681
    • D3DT04
    • Q04198
    • Q5QGT0
    • Q9BWH9

    Protein attributes for REEP5 Gene

    189 amino acids
    Molecular mass:
    21493 Da
    Quaternary structure:
    • Interacts with ATL1 (By similarity). Interacts with ATL2.
    • Sequence=AAA60136.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA66351.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH65926.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for REEP5 Gene


neXtProt entry for REEP5 Gene

Proteomics data for REEP5 Gene at MOPED

Post-translational modifications for REEP5 Gene

  • Ubiquitination at Lys16, Lys147, and Lys157
  • Modification sites at PhosphoSitePlus

Other Protein References for REEP5 Gene

Antibody Products

No data available for DME Specific Peptides for REEP5 Gene

Domains for REEP5 Gene

Gene Families for REEP5 Gene

  • REEP :Receptor accessory proteins

Protein Domains for REEP5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q00765
  • Belongs to the DP1 family.
genes like me logo Genes that share domains with REEP5: view

Function for REEP5 Gene

Molecular function for REEP5 Gene

UniProtKB/Swiss-Prot Function:
May promote functional cell surface expression of olfactory receptors

Gene Ontology (GO) - Molecular Function for REEP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16762630
genes like me logo Genes that share ontologies with REEP5: view

Phenotypes for REEP5 Gene

MGI mutant phenotypes for REEP5:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with REEP5: view

Animal Model Products

miRNA for REEP5 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REEP5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for REEP5 Gene

Localization for REEP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REEP5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for REEP5 Gene COMPARTMENTS Subcellular localization image for REEP5 gene
Compartment Confidence
cytosol 3
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for REEP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with REEP5: view

Pathways for REEP5 Gene

SuperPathways for REEP5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REEP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with REEP5: view

No data available for Pathways by source for REEP5 Gene

Compounds for REEP5 Gene

(4) PharmGKB related drug/compound annotations for REEP5 Gene

Drug/compound Annotation
citalopram CA
fluoxetine CA
paroxetine CA
sertraline CA
genes like me logo Genes that share compounds with REEP5: view

Transcripts for REEP5 Gene

Unigene Clusters for REEP5 Gene

Receptor accessory protein 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REEP5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REEP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP5: -

Relevant External Links for REEP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REEP5 Gene

mRNA expression in normal human tissues for REEP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for REEP5 Gene

This gene is overexpressed in Nasal epithelium (11.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for REEP5 Gene

SOURCE GeneReport for Unigene cluster for REEP5 Gene Hs.429608

genes like me logo Genes that share expressions with REEP5: view

Expression partners for REEP5 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for REEP5 Gene

Orthologs for REEP5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REEP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia REEP5 35
  • 89.77 (n)
  • 90.48 (a)
REEP5 36
  • 90 (a)
(Canis familiaris)
Mammalia LOC479137 35
  • 89.25 (n)
  • 86.29 (a)
REEP5 36
  • 75 (a)
(Mus musculus)
Mammalia Reep5 35
  • 90.48 (n)
  • 93.65 (a)
Reep5 16
Reep5 36
  • 94 (a)
(Pan troglodytes)
Mammalia REEP5 35
  • 99.82 (n)
  • 100 (a)
REEP5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Reep5 35
  • 88.89 (n)
  • 94.18 (a)
(Monodelphis domestica)
Mammalia REEP5 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia REEP5 36
  • 59 (a)
(Gallus gallus)
Aves REEP5 35
  • 80.78 (n)
  • 85.19 (a)
REEP5 36
  • 85 (a)
(Anolis carolinensis)
Reptilia REEP5 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia reep5 35
  • 74.96 (n)
  • 77.78 (a)
Str.6213 35
(Danio rerio)
Actinopterygii -- 35
reep5 35
  • 71.12 (n)
  • 72.73 (a)
reep5 36
  • 72 (a)
reep5 36
  • 72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8928 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004819 35
  • 55.49 (n)
  • 49.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8331 35
  • 58.8 (n)
  • 52.78 (a)
CG4960 36
  • 41 (a)
CG8331 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea yop-1 35
  • 53.33 (n)
  • 47.88 (a)
yop-1 36
  • 43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR063W 35
  • 45.9 (n)
  • 32.57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06601g 35
  • 46.93 (n)
  • 40.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOP1 35
  • 46.09 (n)
  • 38.26 (a)
YOP1 36
  • 32 (a)
YOP1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU06702 35
  • 55.06 (n)
  • 45.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes yop1 35
  • 50.97 (n)
  • 40.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11316 36
  • 48 (a)
Species with no ortholog for REEP5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REEP5 Gene

Gene Tree for REEP5 (if available)
Gene Tree for REEP5 (if available)

Paralogs for REEP5 Gene

Paralogs for REEP5 Gene

Selected SIMAP similar genes for REEP5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with REEP5: view

Variants for REEP5 Gene

Sequence variations from dbSNP and Humsavar for REEP5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs11961 -- 112,902,461(-) TACTG(A/G)GTAGT stop-gained, reference
rs33397 -- 112,902,218(-) aaaaa(A/C)aaaaa intron-variant
rs33570 -- 112,921,545(-) GGAAG(C/G)GGGTG intron-variant
rs149191 -- 112,916,561(-) TACTG(C/T)CATCC intron-variant
rs149193 -- 112,914,664(-) TGAGG(G/T)TACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REEP5 Gene

Variant ID Type Subtype PubMed ID
nsv4960 CNV Loss 18451855
esv26872 CNV Loss 19812545
esv2730601 CNV Deletion 23290073
esv2667456 CNV Deletion 23128226

Relevant External Links for REEP5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REEP5 Gene

Disorders for REEP5 Gene

(4) University of Copenhagen DISEASES for REEP5 Gene

Relevant External Links for REEP5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with REEP5: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for REEP5 Gene

Publications for REEP5 Gene

  1. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H. … Matsunami H. (Cell 2004) 2 3 4
  2. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark A.J. … Huebner A. (Trends Endocrinol. Metab. 2005) 2 3
  3. Identification of FAP locus genes from chromosome 5q21. (PMID: 1651562) Kinzler K.W. … Nakamura Y. (Science 1991) 3 4
  4. Identification of deletion mutations and three new genes at the familial polyposis locus. (PMID: 1678319) Joslyn G. … White R. (Cell 1991) 3 4
  5. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PMID: 18839057) Lesch K.P. … Jacob C. (J Neural Transm 2008) 3 48

Products for REEP5 Gene

Sources for REEP5 Gene

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