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Aliases for REEP4 Gene

Aliases for REEP4 Gene

  • Receptor Accessory Protein 4 2 3 5
  • C8orf20 3 4
  • Receptor Expression-Enhancing Protein 4 3
  • Chromosome 8 Open Reading Frame 20 2
  • PP432 3
  • Yip2c 3

External Ids for REEP4 Gene

Previous HGNC Symbols for REEP4 Gene

  • C8orf20

Previous GeneCards Identifiers for REEP4 Gene

  • GC08M022052
  • GC08M020537
  • GC08M021995

Summaries for REEP4 Gene

GeneCards Summary for REEP4 Gene

REEP4 (Receptor Accessory Protein 4) is a Protein Coding gene. GO annotations related to this gene include microtubule binding. An important paralog of this gene is REEP3.

UniProtKB/Swiss-Prot for REEP4 Gene

  • Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REEP4 Gene

Genomics for REEP4 Gene

Regulatory Elements for REEP4 Gene

Enhancers for REEP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around REEP4 on UCSC Golden Path with GeneCards custom track

Promoters for REEP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for REEP4 Gene

Chromosome:
8
Start:
22,138,020 bp from pter
End:
22,141,951 bp from pter
Size:
3,932 bases
Orientation:
Minus strand

Genomic View for REEP4 Gene

Genes around REEP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REEP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REEP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REEP4 Gene

Proteins for REEP4 Gene

  • Protein details for REEP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6H4-REEP4_HUMAN
    Recommended name:
    Receptor expression-enhancing protein 4
    Protein Accession:
    Q9H6H4
    Secondary Accessions:
    • D3DSQ9
    • Q86VL1
    • Q9H6I5
    • Q9HBP4

    Protein attributes for REEP4 Gene

    Size:
    257 amino acids
    Molecular mass:
    29395 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for REEP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REEP4 Gene

Post-translational modifications for REEP4 Gene

  • Ubiquitination at Lys 101, Lys 111, and Lys 123
  • Modification sites at PhosphoSitePlus

Other Protein References for REEP4 Gene

No data available for DME Specific Peptides for REEP4 Gene

Domains & Families for REEP4 Gene

Gene Families for REEP4 Gene

Protein Domains for REEP4 Gene

Suggested Antigen Peptide Sequences for REEP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6H4

UniProtKB/Swiss-Prot:

REEP4_HUMAN :
  • Belongs to the DP1 family.
Family:
  • Belongs to the DP1 family.
genes like me logo Genes that share domains with REEP4: view

Function for REEP4 Gene

Molecular function for REEP4 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.

Gene Ontology (GO) - Molecular Function for REEP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding ISS --
genes like me logo Genes that share ontologies with REEP4: view
genes like me logo Genes that share phenotypes with REEP4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REEP4 Gene

Localization for REEP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REEP4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for REEP4 Gene COMPARTMENTS Subcellular localization image for REEP4 gene
Compartment Confidence
endoplasmic reticulum 5
cytoskeleton 3
cytosol 2
extracellular 2
golgi apparatus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for REEP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 23911198
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005874 microtubule IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with REEP4: view

Pathways & Interactions for REEP4 Gene

SuperPathways for REEP4 Gene

No Data Available

Interacting Proteins for REEP4 Gene

Gene Ontology (GO) - Biological Process for REEP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IMP 23911198
GO:0007067 mitotic nuclear division IEA --
GO:0007084 mitotic nuclear envelope reassembly IMP 23911198
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with REEP4: view

No data available for Pathways by source and SIGNOR curated interactions for REEP4 Gene

Drugs & Compounds for REEP4 Gene

No Compound Related Data Available

Transcripts for REEP4 Gene

Unigene Clusters for REEP4 Gene

Receptor accessory protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REEP4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: -
SP6: -
SP7:

Relevant External Links for REEP4 Gene

GeneLoc Exon Structure for
REEP4
ECgene alternative splicing isoforms for
REEP4

Expression for REEP4 Gene

mRNA expression in normal human tissues for REEP4 Gene

mRNA differential expression in normal tissues according to GTEx for REEP4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.9), Esophagus - Mucosa (x4.7), and Skin - Sun Exposed (Lower leg) (x4.5).

Protein differential expression in normal tissues from HIPED for REEP4 Gene

This gene is overexpressed in Pancreas (13.8), Plasma (13.1), Placenta (12.7), and Peripheral blood mononuclear cells (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for REEP4 Gene



Protein tissue co-expression partners for REEP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of REEP4 Gene:

REEP4

SOURCE GeneReport for Unigene cluster for REEP4 Gene:

Hs.289063

mRNA Expression by UniProt/SwissProt for REEP4 Gene:

Q9H6H4-REEP4_HUMAN
Tissue specificity: Expressed in circumvallate papillae and testis.
genes like me logo Genes that share expression patterns with REEP4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for REEP4 Gene

Orthologs for REEP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REEP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia REEP4 34
  • 88.46 (n)
  • 89.88 (a)
REEP4 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia REEP4 34
  • 88.98 (n)
  • 92.22 (a)
REEP4 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Reep4 34
  • 85.21 (n)
  • 88.33 (a)
Reep4 16
Reep4 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia REEP4 34
  • 99.61 (n)
  • 99.61 (a)
REEP4 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Reep4 34
  • 84.7 (n)
  • 88.72 (a)
oppossum
(Monodelphis domestica)
Mammalia REEP4 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia REEP4 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia REEP4 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia reep4 34
  • 66.28 (n)
  • 67.19 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:101744 35
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42678 35
  • 16 (a)
ManyToMany
CG5539 35
  • 17 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T19C3.4 35
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOP1 35
  • 18 (a)
OneToMany
Species where no ortholog for REEP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REEP4 Gene

ENSEMBL:
Gene Tree for REEP4 (if available)
TreeFam:
Gene Tree for REEP4 (if available)

Paralogs for REEP4 Gene

Paralogs for REEP4 Gene

(5) SIMAP similar genes for REEP4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with REEP4: view

Variants for REEP4 Gene

Sequence variations from dbSNP and Humsavar for REEP4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1132118 -- 22,138,272(-) GGGTT(C/T)TATTT nc-transcript-variant, utr-variant-3-prime
rs3087597 -- 22,138,304(+) CATTG(G/T)GGGTG nc-transcript-variant, utr-variant-3-prime
rs4872320 -- 22,143,559(+) CACGC(A/G)CCTGA upstream-variant-2KB
rs56401147 -- 22,139,104(+) AGGGA(A/T)ATTGG intron-variant
rs56918043 -- 22,137,561(+) CCTCA(A/G)AGGTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for REEP4 Gene

Variant ID Type Subtype PubMed ID
dgv12054n54 CNV loss 21841781
dgv12055n54 CNV loss 21841781
dgv881n27 CNV loss 19166990
esv2759604 CNV loss 17122850
nsv465613 CNV loss 19166990
nsv470204 CNV loss 18288195
nsv524720 CNV loss 19592680
nsv527293 CNV loss 19592680
nsv528590 CNV loss 19592680
nsv610765 CNV loss 21841781
nsv831263 CNV loss 17160897
nsv831264 CNV gain+loss 17160897

Variation tolerance for REEP4 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REEP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
REEP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REEP4 Gene

Disorders for REEP4 Gene

Relevant External Links for REEP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REEP4

No disorders were found for REEP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REEP4 Gene

Publications for REEP4 Gene

  1. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H. … Matsunami H. (Cell 2004) 2 3 4 65
  2. REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin and proper nuclear envelope architecture. (PMID: 23911198) Schlaitz A.L. … Heald R. (Dev. Cell 2013) 3 4 65
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65
  4. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark A.J. … Huebner A. (Trends Endocrinol. Metab. 2005) 2 3 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for REEP4 Gene

Sources for REEP4 Gene

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