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Aliases for REEP4 Gene

Aliases for REEP4 Gene

  • Receptor Accessory Protein 4 2 3
  • C8orf20 3 4 6
  • Receptor Expression Enhancing Protein 4 3
  • Receptor Expression-Enhancing Protein 4 3
  • Chromosome 8 Open Reading Frame 20 2
  • PP432 3

External Ids for REEP4 Gene

Previous HGNC Symbols for REEP4 Gene

  • C8orf20

Previous GeneCards Identifiers for REEP4 Gene

  • GC08M022052
  • GC08M020537
  • GC08M021995

Summaries for REEP4 Gene

GeneCards Summary for REEP4 Gene

REEP4 (Receptor Accessory Protein 4) is a Protein Coding gene. GO annotations related to this gene include microtubule binding. An important paralog of this gene is REEP2.

UniProtKB/Swiss-Prot for REEP4 Gene

  • Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REEP4 Gene

Genomics for REEP4 Gene

Regulatory Elements for REEP4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for REEP4 Gene

22,138,020 bp from pter
22,141,951 bp from pter
3,932 bases
Minus strand

Genomic View for REEP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REEP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REEP4 Gene

Proteins for REEP4 Gene

  • Protein details for REEP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor expression-enhancing protein 4
    Protein Accession:
    Secondary Accessions:
    • D3DSQ9
    • Q86VL1
    • Q9H6I5
    • Q9HBP4

    Protein attributes for REEP4 Gene

    257 amino acids
    Molecular mass:
    29395 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for REEP4 Gene


neXtProt entry for REEP4 Gene

Proteomics data for REEP4 Gene at MOPED

Post-translational modifications for REEP4 Gene

  • Ubiquitination at Lys101, Lys111, and Lys123
  • Modification sites at PhosphoSitePlus

Other Protein References for REEP4 Gene

No data available for DME Specific Peptides for REEP4 Gene

Domains for REEP4 Gene

Gene Families for REEP4 Gene

  • REEP :Receptor accessory proteins

Protein Domains for REEP4 Gene

Suggested Antigen Peptide Sequences for REEP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H6H4
  • Belongs to the DP1 family.
genes like me logo Genes that share domains with REEP4: view

Function for REEP4 Gene

Molecular function for REEP4 Gene

UniProtKB/Swiss-Prot Function: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.

Gene Ontology (GO) - Molecular Function for REEP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding ISS --
genes like me logo Genes that share ontologies with REEP4: view

Phenotypes for REEP4 Gene

GenomeRNAi human phenotypes for REEP4:
genes like me logo Genes that share phenotypes with REEP4: view

Animal Model Products

CRISPR Products

miRNA for REEP4 Gene

miRTarBase miRNAs that target REEP4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for REEP4 Gene

Localization for REEP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REEP4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for REEP4 Gene COMPARTMENTS Subcellular localization image for REEP4 gene
Compartment Confidence
extracellular 2
golgi apparatus 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for REEP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 23911198
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005874 microtubule IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with REEP4: view

Pathways for REEP4 Gene

SuperPathways for REEP4 Gene

No Data Available

Interacting Proteins for REEP4 Gene

Gene Ontology (GO) - Biological Process for REEP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IMP 23911198
GO:0007067 mitotic nuclear division IEA --
GO:0007084 mitotic nuclear envelope reassembly IMP 23911198
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with REEP4: view

No data available for Pathways by source for REEP4 Gene

Transcripts for REEP4 Gene

Unigene Clusters for REEP4 Gene

Receptor accessory protein 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for REEP4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REEP4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: -
SP6: -

Relevant External Links for REEP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REEP4 Gene

mRNA expression in normal human tissues for REEP4 Gene

mRNA differential expression in normal tissues according to GTEx for REEP4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (4.9), Esophagus - Mucosa (4.7), and Skin - Sun Exposed (Lower leg) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for REEP4 Gene

SOURCE GeneReport for Unigene cluster for REEP4 Gene Hs.289063

genes like me logo Genes that share expressions with REEP4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for REEP4 Gene

Orthologs for REEP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REEP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia REEP4 35
  • 99.61 (n)
  • 99.61 (a)
REEP4 36
  • 100 (a)
(Bos Taurus)
Mammalia REEP4 35
  • 88.46 (n)
  • 89.88 (a)
REEP4 36
  • 90 (a)
(Canis familiaris)
Mammalia REEP4 35
  • 88.98 (n)
  • 92.22 (a)
REEP4 36
  • 92 (a)
(Mus musculus)
Mammalia Reep4 35
  • 85.21 (n)
  • 88.33 (a)
Reep4 16
Reep4 36
  • 88 (a)
(Monodelphis domestica)
Mammalia REEP4 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia REEP4 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Reep4 35
  • 84.7 (n)
  • 88.72 (a)
(Anolis carolinensis)
Reptilia REEP4 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia reep4 35
  • 66.28 (n)
  • 67.19 (a)
(Danio rerio)
Actinopterygii zgc:101744 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42678 36
  • 16 (a)
CG5539 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea T19C3.4 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOP1 36
  • 18 (a)
Species with no ortholog for REEP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REEP4 Gene

Gene Tree for REEP4 (if available)
Gene Tree for REEP4 (if available)

Paralogs for REEP4 Gene

Paralogs for REEP4 Gene

Selected SIMAP similar genes for REEP4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with REEP4: view

Variants for REEP4 Gene

Sequence variations from dbSNP and Humsavar for REEP4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1132118 -- 22,138,272(-) GGGTT(C/T)TATTT utr-variant-3-prime
rs3087597 -- 22,138,304(+) CATTG(G/T)GGGTG utr-variant-3-prime
rs4872320 -- 22,143,559(+) CACGC(A/G)CCTGA upstream-variant-2KB
rs5890025 -- 22,142,508(+) CCTTC(-/CTT/TTC)AGCAG upstream-variant-2KB
rs6994365 -- 22,142,897(+) TTGCC(C/G)TGTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for REEP4 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
dgv7756n71 CNV Loss 21882294
nsv831263 CNV Loss 17160897
nsv528590 CNV Loss 19592680
dgv7757n71 CNV Loss 21882294
nsv890654 CNV Loss 21882294
nsv465613 CNV Loss 19166990
dgv7758n71 CNV Loss 21882294
nsv890657 CNV Loss 21882294
nsv831264 CNV Gain+Loss 17160897
dgv881n27 CNV Loss 19166990
nsv470204 CNV Loss 18288195
nsv527293 CNV Loss 19592680
nsv524720 CNV Loss 19592680
nsv890660 CNV Loss 21882294

Relevant External Links for REEP4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REEP4 Gene

Disorders for REEP4 Gene

No disorders were found for REEP4 Gene.

No data available for UniProtKB/Swiss-Prot for REEP4 Gene

Publications for REEP4 Gene

  1. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H. … Matsunami H. (Cell 2004) 2 3 4
  2. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark A.J. … Huebner A. (Trends Endocrinol. Metab. 2005) 2 3
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin and proper nuclear envelope architecture. (PMID: 23911198) Schlaitz A.L. … Heald R. (Dev. Cell 2013) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for REEP4 Gene

Sources for REEP4 Gene

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