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REEP4 Gene

protein-coding   GIFtS: 50
GCID: GC08M021995

Receptor Accessory Protein 4

(Previous name: chromosome 8 open reading frame 20)
(Previous symbol: C8orf20)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Receptor Accessory Protein 41 2
C8orf201 2 3 5
Chromosome 8 Open Reading Frame 201
Receptor Expression Enhancing Protein 42
Receptor Expression-Enhancing Protein 42

External Ids:    HGNC: 261761   Entrez Gene: 803462   Ensembl: ENSG000001684767   OMIM: 6093495   UniProtKB: Q9H6H43   

Export aliases for REEP4 gene to outside databases

Previous GC identifers: GC08M022052 GC08M020537


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for REEP4 Gene:
REEP4 (receptor accessory protein 4) is a protein-coding gene. GO annotations related to this gene include microtubule binding. An important paralog of this gene is REEP1.

UniProtKB/Swiss-Prot: REEP4_HUMAN, Q9H6H4
Function: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by
sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the
endoplasmic reticulum membrane from metaphase chromosomes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the REEP4 gene promoter:
         GR   AP-1   GR-alpha   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREEP4 promoter sequence
   Search Chromatin IP Primers for REEP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REEP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.3

REEP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REEP4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M021995:  view genomic region     (about GC identifiers)

Start:
21,995,533 bp from pter      End:
21,999,464 bp from pter
Size:
3,932 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: REEP4_HUMAN, Q9H6H4 (See protein sequence)
Recommended Name: Receptor expression-enhancing protein 4  
Size: 257 amino acids; 29395 Da
Secondary accessions: D3DSQ9 Q86VL1 Q9H6I5 Q9HBP4
Alternative splicing: 2 isoforms:  Q9H6H4-1   Q9H6H4-2   

Explore the universe of human proteins at neXtProt for REEP4: NX_Q9H6H4

Explore proteomics data for REEP4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys101, Lys111, Lys123
  • Modification sites at PhosphoSitePlus

  • See REEP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079508.2  
    ENSEMBL proteins: 
     ENSP00000333889   ENSP00000303482   ENSP00000428709   ENSP00000428160   ENSP00000429451  

    REEP4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for REEP4

     
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    antibodies-online proteins for REEP4 

     
    antibodies-online peptides for REEP4

    REEP4 Antibody Products:

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    antibodies-online antibodies for REEP4 (22 products) 

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    Cloud-Clone Corp. CLIAs for REEP4
    Search eBioscience for ELISAs for REEP4 
    antibodies-online kits for REEP4 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    REEP: Receptor accessory proteins

    1 InterPro protein domain:
     IPR004345 TB2_DP1_HVA22

    Graphical View of Domain Structure for InterPro Entry Q9H6H4

    ProtoNet protein and cluster: Q9H6H4

    1 Blocks protein domain: IPB004345 TB2/DP1 and HVA22 related proteins

    UniProtKB/Swiss-Prot: REEP4_HUMAN, Q9H6H4
    Similarity: Belongs to the DP1 family


    Find genes that share domains with REEP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REEP4_HUMAN, Q9H6H4
    Function: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by
    sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the
    endoplasmic reticulum membrane from metaphase chromosomes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008017microtubule binding ISS--
         
    Find genes that share ontologies with REEP4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for REEP4:
     Increased cell number in G2M,  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for REEP4

    miRNA
    Products:
        
    miRTarBase miRNAs that target REEP4:
    hsa-let-7b-5p (MIRT032360), hsa-mir-193b-3p (MIRT041356), hsa-mir-615-3p (MIRT040173)

    Block miRNA regulation of human, mouse, rat REEP4 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate REEP4:
    hsa-miR-188-3p hsa-miR-9 hsa-miR-26a hsa-miR-1252 hsa-miR-3121-3p hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidREEP4 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    REEP4_HUMAN, Q9H6H4: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    golgi apparatus2
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005874microtubule IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with REEP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for REEP4
    Interactions:

        Search GeneGlobe Interaction Network for REEP4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for REEP4 (Q9H6H42, 3 ENSP000003034824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3976408 I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    YIF1AENSP000003660984STRING: ENSP00000366098
    YIF1BENSP000003434354STRING: ENSP00000343435
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006998nuclear envelope organization IMP--
    GO:0007067mitosis IEA--
    GO:0007084mitotic nuclear envelope reassembly IMP--

    Find genes that share ontologies with REEP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for REEP4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for REEP4 gene: 
    NM_025232.2  

    Unigene Cluster for REEP4:

    Receptor accessory protein 4
    Hs.289063  [show with all ESTs]
    Unigene Representative Sequence: BM549819
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334530 ENST00000306306(uc003xau.1 uc010ltt.1) ENST00000523293
    ENST00000518664 ENST00000519074(uc011kyz.1) ENST00000519875 ENST00000521744

    miRNA
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    Block miRNA regulation of human, mouse, rat REEP4 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate REEP4:
    hsa-miR-188-3p hsa-miR-9 hsa-miR-26a hsa-miR-1252 hsa-miR-3121-3p hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidREEP4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for REEP4
    Predesigned siRNA for gene silencing in human, mouse, rat REEP4
    Clone
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    OriGene clones in human, mouse for REEP4 (see all 7)
    OriGene ORF clones in mouse, rat for REEP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REEP4 (NM_025232)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REEP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP4
    Primer
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    OriGene qPCR primer pairs and template standards for REEP4
    OriGene qSTAR qPCR primer pairs in human, mouse for REEP4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REEP4
      QuantiTect SYBR Green Assays in human, mouse, rat REEP4
      QuantiFast Probe-based Assays in human, mouse, rat REEP4

    Additional mRNA sequence: 

    AF218014.1 AK025899.1 AK025930.1 AK172846.1 AK302352.1 AY562242.1 BC013048.1 BC050622.1 
    CR457353.1 

    10 DOTS entries:

    DT.440968  DT.100792606  DT.75151495  DT.92438601  DT.40235301  DT.100792613  DT.100792614  DT.100792621 
    DT.100658681  DT.95320651 

    Selected AceView cDNA sequences (see all 241):

    CR609300 BI822873 BM553986 BX476366 CR620176 CR620257 BI828929 BE207101 
    BM766842 AI698753 CR625559 AA412213 CR621198 BQ067258 CR616321 BC013048 
    BQ002700 CR596798 AL522565 BP352370 CR620416 AL548567 CA489155 AA232705 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for REEP4 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c
    SP1:                                                              -           -     -                                 
    SP2:                                                              -           -     -     -                           
    SP3:                                                              -           -     -           -                     
    SP4:                                            -                                                                     
    SP5:                                                                          -                                       


    ECgene alternative splicing isoforms for REEP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    REEP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    REEP4 Expression
    About this image

    REEP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REEP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.289063
        Custom PCR Arrays for REEP4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for REEP4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Reep41 , 5 receptor accessory protein 41, 5 85.21(n)1
    88.33(a)1
      14 (36.32 cM)5
    725491  NM_180588.21  NP_850919.11 
     705452515 
    lizard
    (Anolis carolinensis)
    Reptilia REEP46
    receptor accessory protein 4
    68(a)
    1 ↔ 1
    GL343608.1(71153-78644)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL878070.22   -- 76.15(n)    AL878070.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1017446
    zgc:101744
    26(a)
    many ↔ many
    2(36810195-36824455) ENSDARG00000038694
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55396
    CG426786
    --
    17(a)
    16(a)
    many ↔ many
    many ↔ many
    2R(19692334-19693411)
    2R(18812613-18819567)
    worm
    (Caenorhabditis elegans)
    Secernentea T19C3.46
    Protein T19C3.4 (T19C3.4) mRNA, complete cds
    40(a)
    1 → many
    III(618248-620212) WBGene00020562
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YOP16
    Membrane protein that interacts with Yip1p to medi...
    18(a)
    1 → many
    XVI(623527-624202) YPR028W


    ENSEMBL Gene Tree for REEP4 (if available)
    TreeFam Gene Tree for REEP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for REEP4 gene
    REEP12  REEP32  REEP52  REEP62  REEP22  
    5 SIMAP similar genes for REEP4 using alignment to 4 protein entries:     REEP4_HUMAN (see all proteins):
    REEP1    REEP2    REEP3    REEP5    REEP6

    Find genes that share paralogs with REEP4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    10 SNPs for REEP4    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106058501,2
    C--21998447(+) GTGAGAG/-GACAG 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs58900251,2
    C--22000021(+) CCTTC-/CT    
       T
    /TTC
    AGCAG
    2 -- cds11NA 2
    rs1842109051,2
    --22001284(+) GGAGTG/TTCACC 1 -- us2k10--------
    rs1161918961,2
    C,F--22001305(+) TTGGCA/CGAGTG 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1871818371,2
    --22001410(+) GCCCCA/CGGGCA 1 -- us2k10--------
    rs351096291,2
    ----22001251(+) GCTCAG/TCACGG 1 -- us2k10--------
    rs3777006711,2
    ----21998493(+) CCTCC-/TCCCATGG 2 -- int1 cds10--------
    rs3755496221,2
    ----21997134(+) AGCCC-/AGCCC 
            
    CACCT
    1 -- int10--------
    rs725773221,2
    ----22000023(+) TCCTT-/TTCCWGCA 1 -- cds10--------
    rs339724011,2
    ----22000025(+) CTTCA-/C/T   
       C
    /TTC
    GCAGA
    2 -- us2k1 cds10--------

    HapMap Linkage Disequilibrium report for REEP4 (21995533 - 21999464 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for REEP4 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527293CNV Loss19592680
    dgv7758n71CNV Loss21882294
    nsv528590CNV Loss19592680
    dgv881n27CNV Loss19166990
    nsv465613CNV Loss19166990
    nsv470204CNV Loss18288195
    dgv7757n71CNV Loss21882294
    nsv524720CNV Loss19592680
    nsv890654CNV Loss21882294
    nsv890657CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing REEP4
    DNA2.0 Custom Variant and Variant Library Synthesis for REEP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609349    OMIM disorders: --


    Find genes that share disorders with REEP4           About GenesLikeMe


    Export disorders for REEP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for REEP4 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with REEP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RTP family members induce functional expression of mammalian odorant receptors. (PubMed id 15550249)1, 2, 3 Saito H.... Matsunami H. (Cell 2004)
    2. REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin and proper nuclear envelope architecture. (PubMed id 23911198)1, 2 Schlaitz A.L.... Heald R. (Dev. Cell 2013)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PubMed id 16271481)1, 3 Clark A.J....Huebner A. (Trends Endocrinol. Metab. 2005)
    5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PubMed id 23505323)1 Weissglas-Volkov D....Pajukanta P. (J. Med. Genet. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80346 HGNC: 26176 AceView: C8orf20 Ensembl:ENSG00000168476 euGenes: HUgn80346
    ECgene: REEP4 H-InvDB: REEP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for REEP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for REEP4 gene:
    Search GeneIP for patents involving REEP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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