REEP3 Gene

Aliases
for REEP3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC10P064952 GC10P059317

Summaries
for REEP3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for REEP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000010.10  NT_030059.14  NC_018921.2  

SwitchGear Promoter luciferase reporter plasmid: REEP3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REEP3

REEP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P065281:  view genomic region     (about GC identifiers)

Proteins
for REEP3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for REEP3: NX_Q6NUK4

Explore proteomics data for REEP3 at MOPED

Post-translational modifications: 

REEP3 Human Recombinant Protein Products:

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	Novus Biologicals REEP3 Protein Novus Biologicals REEP3 Lysate
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	Cloud-Clone Corp. Proteins for REEP3
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	Search GeneTex for Proteins for REEP3
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	antibodies-online peptides for REEP3

REEP3 Antibody Products:

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	antibodies-online antibodies for REEP3 (12 products)

REEP3 Assay Products:

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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for REEP3 Cloud-Clone Corp. CLIAs for REEP3
	Search eBioscience for ELISAs for REEP3
	antibodies-online kits for REEP3 (4 products)

Domains /
Families
for REEP3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q6NUK4

Find genes that share domains with REEP3           About GenesLikeMe

Function
for REEP3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for REEP3

miRNA Products:		miRTarBase miRNAs that target REEP3: hsa-mir-96-5p (MIRT027898), hsa-mir-34a-5p (MIRT025553), hsa-mir-93-5p (MIRT028114), hsa-mir-374b-5p (MIRT016063), hsa-mir-590-3p (MIRT016224), hsa-mir-375 (MIRT020016), hsa-mir-335-5p (MIRT018792), hsa-mir-26b-5p (MIRT030093)
		Block miRNA regulation of human, mouse, rat REEP3 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate REEP3 (see all 95):
		hsa-miR-520e hsa-miR-607 hsa-miR-106a hsa-miR-200a hsa-miR-30d hsa-miR-30a hsa-miR-149 hsa-miR-93
		SwitchGear 3'UTR luciferase reporter plasmid: REEP3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for REEP3
		Predesigned siRNA for gene silencing in human, mouse, rat REEP3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for REEP3

Clone Products:		OriGene clones in human, mouse for REEP3 (see all 6) OriGene ORF clones in mouse, rat for REEP3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: REEP3 (NM_001001330)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for REEP3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for REEP3
		Browse ESI BIO Cell Lines and PureStem Progenitors for REEP3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP3

Localization
for REEP3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
golgi apparatus	2
endoplasmic reticulum	1
extracellular	1
mitochondrion	1
peroxisome	1
plasma membrane	1

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for REEP3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for REEP3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for REEP3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for REEP3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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REEP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACTTAACATT

About this image

Blood (Hematopoietic System)
Monocytes Peripheral Blood
Brain (Nervous System)
Myelinating Oligodendrocyte Cells Forebrain White Matter

Primer Products:		OriGene qPCR primer pairs and template standards for REEP3 OriGene qSTAR qPCR primer pairs in human, mouse for REEP3
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REEP3
		QuantiTect SYBR Green Assays in human, mouse, rat REEP3
		QuantiFast Probe-based Assays in human, mouse, rat REEP3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP3

Orthologs
for REEP3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for REEP3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for REEP3 gene

REEP4²  REEP1²  REEP5²  REEP6²  REEP2²  

3 SIMAP similar genes for REEP3 using alignment to 2 protein entries:     REEP3_HUMAN (see all proteins):

REEP1    REEP4    REEP2

Find genes that share paralogs with REEP3           About GenesLikeMe

Genomic Variants
for REEP3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for REEP3 (see all 1734)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1834303921,2		--	65279305(+)	ATTCAA/GTACAT	1	--	us2k1		0	--	--	--	--
rs1882877541,2		--	65279311(+)	TACATA/TAGACA	1	--	us2k1		0	--	--	--	--
rs1922353371,2		--	65279347(+)	AGAAAC/TAGAAA	1	--	us2k1		0	--	--	--	--
rs763786001,2	F	--	65279420(+)	AGGATG/ATCTTC	1	--	us2k1		2		WA NA	238
rs1829333351,2		--	65279482(+)	CAAAGC/TGTTAA	1	--	us2k1		0	--	--	--	--
rs1412215761,2	C	--	65279760(+)	ATTCAC/GAGTTA	1	--	us2k1		0	--	--	--	--
rs797613981,2		--	65279868(+)	TTGTTA/TCTTAA	1	--	us2k1		0	--	--	--	--
rs70710911,2	C,F	--	65279908(+)	GAGAAC/GTGAAA	1	--	us2k1		2		WA NA	238
rs1876351971,2		--	65280163(+)	TATTCA/TTCGCA	1	--	us2k1		0	--	--	--	--
rs108221791,2	C,F,A,H	--	65280164(+)	ATTCTC/TCGCAC	1	--	us2k1		24		NS EA NA WA	2760

HapMap Linkage Disequilibrium report for REEP3 (65281123 - 65384883 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for REEP3:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2737640	CNV	Deletion	23290073
esv2334532	CNV	Deletion	18987734
esv272741	CNV	Insertion	20981092
nsv895571	CNV	Loss	21882294
esv22964	CNV	Loss	19812545

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing REEP3

DNA2.0 Custom Variant and Variant Library Synthesis for REEP3

Disorders / Diseases
for REEP3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for REEP3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. RTP family members induce functional expression of mammalian odorant receptors. (PubMed id 15550249)^{1, 2, 3} Saito H.... Matsunami H. (Cell 2004)
2. Identification and characterization of the TRIP8 and REEP3 genes on chromosome 10q21.3 as novel candidate genes for autism. (PubMed id 17290275)^{1, 2, 9} Castermans D....Devriendt K. (Eur. J. Hum. Genet. 2007)
3. REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin and proper nuclear envelope architecture. (PubMed id 23911198)^{1, 2} Schlaitz A.L.... Heald R. (Dev. Cell 2013)
4. Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. (PubMed id 22354554)^{1, 4} Thompson S.D....Glass D.N. (Arthritis Rheum. 2012)
5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
6. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PubMed id 18940312)^{1, 4} Yuan X....Mooser V. (Am. J. Hum. Genet. 2008)
7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)^{1, 4} Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
8. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PubMed id 16271481)^{1, 3} Clark A.J....Huebner A. (Trends Endocrinol. Metab. 2005)
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
10. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (Nature 2004)

External Searches for REEP3 gene

Genome Databases showing REEP3 gene

Other Databases showing REEP3 gene

Specialized Databases showing REEP3 gene

Products
for REEP3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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