REEP3 Gene
protein-coding GIFtS: 49
GCID: GC10P065281
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receptor accessory protein 3(Previous name: chromosome 10 open reading frame 74 )
(Previous symbol: C10orf74)
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Aliases
for REEP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Receptor Accessory Protein 31 2 | | C10orf741 2 3 5 | | Chromosome 10 Open Reading Frame 741 | | Receptor Expression Enhancing Protein 32 | | Receptor Expression-Enhancing Protein 32 |
Export aliases for REEP3 gene to outside databasesPrevious GC identifers: GC10P064952 GC10P059317 |
Summaries
for REEP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: REEP3_HUMAN, Q6NUK4Function: May enhance the cell surface expression of odorant receptors (By similarity)
|
Genomic Views
for REEP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the REEP3 gene promoter:
Max1 ER-alpha HTF AP-2gamma FOXJ2 (long isoform) Sox9 AP-2beta AP-2alpha c-Myc AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for REEP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REEP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q21.3 Ensembl cytogenetic band: 10q21.3 HGNC cytogenetic band: 10q21.3REEP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P065281: view genomic region
(about GC identifiers)
Start:
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65,281,123 bp from pter |
End:
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65,384,883 bp from pter |
Size:
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103,761 bases |
Orientation:
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plus strand |
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Proteins
for REEP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: REEP3_HUMAN, Q6NUK4 (See
protein sequence)Recommended Name: Receptor expression-enhancing protein 3 Size: 255 amino acids; 29264 Da
Subunit: Interacts with odorant receptor proteins (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAH10040.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: Q5JQR5 Q5QGT2 Q6PEW8 Q6PJY4Alternative splicing: 2 isoforms: Q6NUK4-1 Q6NUK4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for REEP3: NX_Q6NUK4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NUK4
REEP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001001330.1
ENSEMBL proteins: ENSP00000298249 ENSP00000362863
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
REEP3 for ontologies About GeneDecksing
REEP3 Antibody Products:
Assay Products for REEP3: |
Protein
Domains /
Families
for REEP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
REEP3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6NUK4ProtoNet protein and cluster: Q6NUK4 1 Blocks protein family: IPB004345 TB2/DP1 and HVA22 related proteins
UniProtKB/Swiss-Prot: REEP3_HUMAN, Q6NUK4Similarity: Belongs to the DP1 family |
Function
for REEP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: REEP3_HUMAN, Q6NUK4Function: May enhance the cell surface expression of odorant receptors (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REEP3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REEP3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: REEP3 (NM_001001330) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for REEP3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP3 |
|
Pathways & Interactions
for REEP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for REEP3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for REEP3 (Q6NUK42, 3 ENSP000003628634) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for REEP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for REEP3
Search CenterWatch for drugs/clinical trials and news about REEP3
|
Transcripts
for REEP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for REEP3 gene: NM_001001330.2 Unigene Cluster for REEP3: Receptor accessory protein 3 Hs.499833 [show with all ESTs]Unigene Representative Sequence: NM_0010013302 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000298249 ENST00000373758(uc009xpl.2 uc001jmt.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REEP3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REEP3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: REEP3 (NM_001001330) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for REEP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP3 |
Additional cDNA sequence: AK289976.1 AY562241.1 BC010040.2 BC018658.1 BC038724.1 BC057832.1 BC068557.1 CR936686.1 11 DOTS entries: DT.415955 DT.80102037 DT.91686888 DT.95164555 DT.95164557 DT.97838862 DT.100021448 DT.95164559 DT.121260033 DT.40250675 DT.91765865 24/154 AceView cDNA sequences (see all 154): AA100609 AA620591 AI192275 BU197986 BM830660 AI079315 BX494303 AI499277 W56228 AL118571 CA455063 BI826741 BX280876 BM761268 CA422715 BM841117 BC057832 AI922029 AA730643 W31882 BC010040 AA548384 BQ225487 CA489790
GeneLoc Exon Structure
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Expression
for REEP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| REEP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTAACATT
About this image
See REEP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for REEP3
SOURCE GeneReport for Unigene cluster: Hs.499833
SABiosciences Custom PCR Arrays for REEP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REEP3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REEP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REEP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REEP3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP3 |
Orthologs
for REEP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for REEP3 gene from 8/24 species (see all 24) About this table
ENSEMBL Gene Tree for REEP3 (if available)
TreeFam Gene Tree for REEP3 (if available) |
Paralogs
for REEP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for REEP3 gene
- REEP12 REEP42 REEP62 REEP52 REEP22
3 SIMAP similar genes for REEP3 using alignment to 2 protein entries: REEP3_HUMAN (see all proteins):REEP1 REEP4 REEP2
REEP3 for paralogs About GeneDecksing
|
Genomic Variants
for REEP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for REEP3 (65281123 - 65384883 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for REEP3
1 Indel: 71029 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REEP3 |
|
Disorders
/ Diseases
for REEP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
REEP3 for disorders About GeneDecksing
OMIM gene information: 609348
OMIM disorders: --
1  disease for REEP3: About MalaCardsalzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: REEP3 (3 documents)
Export disorders for REEP3 gene to outside databases
|
Publications
for REEP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for REEP3 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with REEP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- RTP family members induce functional expression of mammalian odorant receptors. (PubMed id 15550249)1, 2, 3 Saito H....Matsunami H. (2004)
- Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PubMed id 16271481)1, 3 Clark A.J....Huebner A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Identification and characterization of the TRIP8 and REEP3 genes on chromosome 10q21.3 as novel candidate genes for autism. (PubMed id 17290275)1, 9 Castermans D....Devriendt K. (2007)
- Genome-wide association analysis of juvenile idiopathi c arthritis identifies a new susceptibility locus at chromosomal region 3q13. (PubMed id 22354554)1 Thompson S.D....Glass D.N. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
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External Searches for REEP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing REEP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing REEP3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing REEP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for REEP3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for REEP3 gene:
Search GeneIP for patents involving REEP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for REEP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for REEP3 | | OriGene shRNA RFP for REEP3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for REEP3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for REEP3 | | | OriGene Protein Over-expression Lysate for REEP3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for REEP3 | | OriGene 3'-UTR Clone for REEP3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for REEP3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for REEP3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for REEP3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for REEP3 | | OriGene Custom Protein Services for REEP3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat REEP3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing REEP3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REEP3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REEP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REEP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REEP3 |
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| | | | Search Tocris compounds for REEP3 |
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 | | | REEP3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP3 |
|  |  |  | | | | ThermoFisher Antibodies for REEP3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP3 |
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