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REEP3 Gene

protein-coding GIFtS: 54
GCID: GC10P065281

Receptor Accessory Protein 3

(Previous name: chromosome 10 open reading frame 74)
(Previous symbol: C10orf74)

Alzheimer's & Parkinson's Diseases Congress

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Receptor Accessory Protein 3¹ ²
C10orf74¹ ² ³ ⁵
Chromosome 10 Open Reading Frame 74¹
Receptor Expression Enhancing Protein 3²
Receptor Expression-Enhancing Protein 3²

External Ids:	HGNC: 23711¹	Entrez Gene: 221035²	Ensembl: ENSG00000165476⁷	OMIM: 609348⁵	UniProtKB: Q6NUK4³

Export aliases for REEP3 gene to outside databases

Previous GC identifers: GC10P064952 GC10P059317

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for REEP3 Gene:

REEP3 (receptor accessory protein 3) is a protein-coding gene. Diseases associated with REEP3 include arthritis, and alzheimer's disease. An important paralog of this gene is REEP4.

UniProtKB/Swiss-Prot: REEP3_HUMAN, Q6NUK4

Function: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by

sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the

endoplasmic reticulum membrane from metaphase chromosomes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000010.11 NT_030059.14 NC_018921.2

Regulatory elements:

Regulatory transcription factor binding sites in the REEP3 gene promoter:
Max1 ER-alpha HTF AP-2gamma FOXJ2 (long isoform) Sox9 AP-2beta AP-2alpha c-Myc AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: REEP3 promoter sequence

Search Chromatin IP Primers for REEP3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REEP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3 Ensembl cytogenetic band: 10q21.3 HGNC cytogenetic band: 10q21.3

REEP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REEP3 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P065281: view genomic region (about GC identifiers)

Start:	65,281,123 bp from pter	End:	65,384,883 bp from pter
Size:	103,761 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: REEP3_HUMAN, Q6NUK4 (See protein sequence)

Recommended Name: Receptor expression-enhancing protein 3

Size: 255 amino acids; 29264 Da

Sequence caution: Sequence=AAH10040.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential

poly-A sequence;

Secondary accessions: Q5JQR5 Q5QGT2 Q6PEW8 Q6PJY4

Alternative splicing: 2 isoforms: Q6NUK4-1 Q6NUK4-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for REEP3: NX_Q6NUK4

Explore proteomics data for REEP3 at MOPED

Post-translational modifications:

Ubiquitination² at Lys99, Lys111

Modification sites at PhosphoSitePlus

See REEP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001001330.1

ENSEMBL proteins:

ENSP00000298249 ENSP00000362863

REEP3 Human Recombinant Protein Products:

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REEP3 Antibody Products:

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	ThermoFisher Antibodies for REEP3
	LSBio Antibodies in human, mouse, rat for REEP3

REEP3 Assay Products:

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	GenScript Custom Assay Services for REEP3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for REEP3 Cloud-Clone Corp. CLIAs for REEP3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

REEP: Receptor accessory proteins

1 InterPro protein domain:

IPR004345 TB2_DP1_HVA22

Graphical View of Domain Structure for InterPro Entry Q6NUK4

ProtoNet protein and cluster: Q6NUK4

1 Blocks protein domain: IPB004345 TB2/DP1 and HVA22 related proteins

UniProtKB/Swiss-Prot: REEP3_HUMAN, Q6NUK4

Similarity: Belongs to the DP1 family

REEP3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: REEP3_HUMAN, Q6NUK4

Function: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by

sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the

endoplasmic reticulum membrane from metaphase chromosomes

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for REEP3

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miRNA Products:		miRTarBase miRNAs that target REEP3: hsa-mir-96-5p (MIRT027898), hsa-mir-34a-5p (MIRT025553), hsa-mir-93-5p (MIRT028114), hsa-mir-374b-5p (MIRT016063), hsa-mir-590-3p (MIRT016224), hsa-mir-375 (MIRT020016), hsa-mir-335-5p (MIRT018792), hsa-mir-26b-5p (MIRT030093)

		Block miRNA regulation of human, mouse, rat REEP3 using miScript Target Protectors
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		SwitchGear 3'UTR luciferase reporter plasmid: REEP3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for REEP3
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

REEP3_HUMAN, Q6NUK4: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
golgi apparatus	2
endoplasmic reticulum	1
extracellular	1
mitochondrion	1
peroxisome	1
plasma membrane	1

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005874	microtubule	IEA	--
GO:0016021	integral component of membrane	IEA	--

REEP3 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for REEP3
Interactions:

Search GeneGlobe Interaction Network for REEP3

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5 Interacting proteins for REEP3 (Q6NUK4^{2, 3} ENSP00000362863⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SFN	P31947²^,³	MINT-3976629 I2D: score=1
ARL6IP5	O75915³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
YIF1A	ENSP00000366098⁴	STRING: ENSP00000366098
YIF1B	ENSP00000343435⁴	STRING: ENSP00000343435

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Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006998	nuclear envelope organization	IMP	--
GO:0007067	mitosis	IEA	--
GO:0007084	mitotic nuclear envelope reassembly	IMP	--

REEP3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for REEP3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for REEP3 gene:

NM_001001330.2

Unigene Cluster for REEP3:

Receptor accessory protein 3

Hs.499833 [show with all ESTs]

Unigene Representative Sequence: NM_001001330

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000298249 ENST00000373758(uc009xpl.2 uc001jmt.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat REEP3 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate REEP3 (see all 95):
		hsa-miR-520e hsa-miR-607 hsa-miR-106a hsa-miR-200a hsa-miR-30d hsa-miR-30a hsa-miR-149 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: REEP3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for REEP3
		Predesigned siRNA for gene silencing in human, mouse, rat REEP3

Clone Products:		OriGene clones in human, mouse for REEP3 (see all 6) OriGene ORF clones in mouse, rat for REEP3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: REEP3 (NM_001001330)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for REEP3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP3

Primer Products:		OriGene qPCR primer pairs and template standards for REEP3 OriGene qSTAR qPCR primer pairs in human, mouse for REEP3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat REEP3
		QuantiTect SYBR Green Assays in human, mouse, rat REEP3
		QuantiFast Probe-based Assays in human, mouse, rat REEP3

Additional mRNA sequence:

AK289976.1 AY562241.1 BC010040.2 BC018658.1 BC038724.1 BC057832.1 BC068557.1 CR936686.1

11 DOTS entries:

DT.415955 DT.80102037 DT.91686888 DT.95164555 DT.95164557 DT.97838862 DT.100021448 DT.95164559

DT.121260033 DT.40250675 DT.91765865

Selected AceView cDNA sequences (see all 154):

W56228 BQ225487 AA548384 CA455063 AA620591 BM761268 CA422715 BI826741

AI922029 AA100609 AI499277 BU197986 BM841117 W31882 BC010040 AI192275

AL118571 BC057832 AI079315 BM830660 BX280876 BX494303 AA730643 AI050673

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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REEP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACTTAACATT

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REEP3 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Blood (Hematopoietic System)
Monocytes Peripheral Blood

Brain (Nervous System)
Myelinating Oligodendrocyte Cells Forebrain White Matter

REEP3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

REEP3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.499833

Custom PCR Arrays for REEP3

Primer Products:		OriGene qPCR primer pairs and template standards for REEP3 OriGene qSTAR qPCR primer pairs in human, mouse for REEP3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat REEP3
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for REEP3 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Reep3^{1 , 5}	receptor accessory protein 3^{1, 5}	84.38(n)¹ 92.52(a)¹		10 (34.83 cM)⁵ 28193¹ NM_178606.5¹ NP_848721.1¹ 67009189⁵
chicken (Gallus gallus)	Aves	REEP3¹	receptor accessory protein 3	79.22(n) 83.92(a)		423654 NM_001199532.1 NP_001186461.1
lizard (Anolis carolinensis)	Reptilia	REEP3⁶	receptor accessory protein 3	69(a)	1 ↔ 1	GL343204.1(2295507-2333207)
African clawed frog (Xenopus laevis)	Amphibia	MGC68764²	hypothetical protein MGC68764	74.05(n)		BC063730.1
zebrafish (Danio rerio)	Actinopterygii	zgc55529²	hypothetical protein MGC55529	75.1(n)		393130 BC045373.1
fruit fly (Drosophila melanogaster)	Insecta	CG5539⁶ CG42678⁶	--	16(a) 14(a)	many ↔ many many ↔ many	2R(19692334-19693411) 2R(18812613-18819567)
worm (Caenorhabditis elegans)	Secernentea	T19C3.4⁶	Protein T19C3.4 (T19C3.4) mRNA, complete cds	37(a)	1 → many	III(618248-620212) WBGene00020562
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	YOP1⁶	Membrane protein that interacts with Yip1p to medi...	20(a)	1 → many	XVI(623527-624202) YPR028W

ENSEMBL Gene Tree for REEP3 (if available)
TreeFam Gene Tree for REEP3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for REEP3 gene

REEP4² REEP1² REEP5² REEP6² REEP2²

3 SIMAP similar genes for REEP3 using alignment to 2 protein entries: REEP3_HUMAN (see all proteins):

REEP1 REEP4 REEP2

REEP3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183430392^1,2		--	65279305(+)	`ATTCAA/GTACAT`	1	--	us2k¹		0	--	--	--	--
rs188287754^1,2		--	65279311(+)	`TACATA/TAGACA`	1	--	us2k¹		0	--	--	--	--
rs192235337^1,2		--	65279347(+)	`AGAAAC/TAGAAA`	1	--	us2k¹		0	--	--	--	--
rs76378600^1,2	F	--	65279420(+)	`AGGATG/ATCTTC`	1	--	us2k¹		2		WA NA	238
rs182933335^1,2		--	65279482(+)	`CAAAGC/TGTTAA`	1	--	us2k¹		0	--	--	--	--
rs141221576^1,2	C	--	65279760(+)	`ATTCAC/GAGTTA`	1	--	us2k¹		0	--	--	--	--
rs79761398^1,2		--	65279868(+)	`TTGTTA/TCTTAA`	1	--	us2k¹		0	--	--	--	--
rs7071091^1,2	C,F	--	65279908(+)	`GAGAAC/GTGAAA`	1	--	us2k¹		2		WA NA	238
rs187635197^1,2		--	65280163(+)	`TATTCA/TTCGCA`	1	--	us2k¹		0	--	--	--	--
rs10822179^1,2	C,F,A,H	--	65280164(+)	`ATTCTC/TCGCAC`	1	--	us2k¹		24		NS EA NA WA	2760

HapMap Linkage Disequilibrium report for REEP3 (65281123 - 65384883 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for REEP3: About this table

Variant ID	Type	Subtype	PubMed ID
esv2737640	CNV	Deletion	23290073
esv2334532	CNV	Deletion	18987734
esv272741	CNV	Insertion	20981092
nsv895571	CNV	Loss	21882294
esv22964	CNV	Loss	19812545

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing REEP3

DNA2.0 Custom Variant and Variant Library Synthesis for REEP3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609348 OMIM disorders: --

2 diseases for REEP3:
About MalaCards

arthritis alzheimer's disease

REEP3 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): REEP3
Human Genome Epidemiology (HuGE) Navigator: REEP3 (3 documents)

Export disorders for REEP3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for REEP3 gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with REEP3)

Utopia: connect your pdf to the dynamic
world of online information

RTP family members induce functional expression of mammalian odorant receptors. (PubMed id 15550249)^{1, 2, 3} Saito H.... Matsunami H. (Cell 2004)
Identification and characterization of the TRIP8 and REEP3 genes on chromosome 10q21.3 as novel candidate genes for autism. (PubMed id 17290275)^{1, 2, 9} Castermans D....Devriendt K. (Eur. J. Hum. Genet. 2007)
REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin and proper nuclear envelope architecture. (PubMed id 23911198)^{1, 2} Schlaitz A.L.... Heald R. (Dev. Cell 2013)
Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. (PubMed id 22354554)^{1, 4} Thompson S.D....Glass D.N. (Arthritis Rheum. 2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PubMed id 18940312)^{1, 4} Yuan X....Mooser V. (Am. J. Hum. Genet. 2008)
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)^{1, 4} Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PubMed id 16271481)^{1, 3} Clark A.J....Huebner A. (Trends Endocrinol. Metab. 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (Nature 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 221035	HGNC: 23711	AceView: C10orf74	Ensembl:ENSG00000165476	euGenes: HUgn221035
ECgene: REEP3	H-InvDB: REEP3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for REEP3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for REEP3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for REEP3 gene:
Search GeneIP for patents involving REEP3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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REEP3 Gene

Receptor Accessory Protein 3

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