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Aliases for REEP3 Gene

Aliases for REEP3 Gene

  • Receptor Accessory Protein 3 2 3
  • C10orf74 3 4 6
  • Receptor Expression Enhancing Protein 3 3
  • Receptor Expression-Enhancing Protein 3 3
  • Chromosome 10 Open Reading Frame 74 2

External Ids for REEP3 Gene

Previous HGNC Symbols for REEP3 Gene

  • C10orf74

Previous GeneCards Identifiers for REEP3 Gene

  • GC10P064952
  • GC10P065281
  • GC10P059317

Summaries for REEP3 Gene

GeneCards Summary for REEP3 Gene

REEP3 (Receptor Accessory Protein 3) is a Protein Coding gene. An important paralog of this gene is REEP2.

UniProtKB/Swiss-Prot for REEP3 Gene

  • Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REEP3 Gene

Genomics for REEP3 Gene

Regulatory Elements for REEP3 Gene

Genomic Location for REEP3 Gene

63,521,353 bp from pter
63,625,123 bp from pter
103,771 bases
Plus strand

Genomic View for REEP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for REEP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REEP3 Gene

Proteins for REEP3 Gene

  • Protein details for REEP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor expression-enhancing protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5JQR5
    • Q5QGT2
    • Q6PEW8
    • Q6PJY4

    Protein attributes for REEP3 Gene

    255 amino acids
    Molecular mass:
    29264 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH10040.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for REEP3 Gene


neXtProt entry for REEP3 Gene

Proteomics data for REEP3 Gene at MOPED

Post-translational modifications for REEP3 Gene

  • Ubiquitination at Lys99 and Lys111
  • Modification sites at PhosphoSitePlus

Other Protein References for REEP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for REEP3 Gene

Domains for REEP3 Gene

Gene Families for REEP3 Gene

  • REEP :Receptor accessory proteins

Protein Domains for REEP3 Gene

Suggested Antigen Peptide Sequences for REEP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6NUK4
  • Belongs to the DP1 family.
genes like me logo Genes that share domains with REEP3: view

Function for REEP3 Gene

Molecular function for REEP3 Gene

UniProtKB/Swiss-Prot Function: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for REEP3 Gene

Localization for REEP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REEP3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for REEP3 Gene COMPARTMENTS Subcellular localization image for REEP3 gene
Compartment Confidence
golgi apparatus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for REEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005874 microtubule IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with REEP3: view

Pathways for REEP3 Gene

SuperPathways for REEP3 Gene

No Data Available

Interacting Proteins for REEP3 Gene

Gene Ontology (GO) - Biological Process for REEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IMP 23911198
GO:0007067 mitotic nuclear division IEA --
GO:0007084 mitotic nuclear envelope reassembly IMP 23911198
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with REEP3: view

No data available for Pathways by source for REEP3 Gene

Transcripts for REEP3 Gene

mRNA/cDNA for REEP3 Gene

Unigene Clusters for REEP3 Gene

Receptor accessory protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for REEP3 Gene

No ASD Table

Relevant External Links for REEP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REEP3 Gene

mRNA expression in normal human tissues for REEP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for REEP3 Gene

SOURCE GeneReport for Unigene cluster for REEP3 Gene Hs.499833

genes like me logo Genes that share expressions with REEP3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for REEP3 Gene

Orthologs for REEP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REEP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia REEP3 35
  • 99.59 (n)
  • 99.18 (a)
REEP3 36
  • 96 (a)
(Bos Taurus)
Mammalia REEP3 35
  • 91.76 (n)
  • 95.29 (a)
REEP3 36
  • 95 (a)
(Canis familiaris)
Mammalia REEP3 35
  • 91.53 (n)
  • 92.62 (a)
REEP3 36
  • 93 (a)
(Mus musculus)
Mammalia Reep3 35
  • 84.38 (n)
  • 92.52 (a)
Reep3 16
Reep3 36
  • 93 (a)
(Monodelphis domestica)
Mammalia REEP3 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia REEP3 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Reep3 35
  • 83.33 (n)
  • 92.91 (a)
(Gallus gallus)
Aves REEP3 35
  • 79.22 (n)
  • 83.92 (a)
REEP3 36
  • 83 (a)
(Anolis carolinensis)
Reptilia REEP3 36
  • 69 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68764 35
tropical clawed frog
(Silurana tropicalis)
Amphibia reep3 35
  • 71.13 (n)
  • 74.8 (a)
(Danio rerio)
Actinopterygii reep3a 36
  • 64 (a)
reep3b 35
  • 66.26 (n)
  • 71.54 (a)
reep3b 36
  • 67 (a)
zgc55529 35
fruit fly
(Drosophila melanogaster)
Insecta CG42678 36
  • 14 (a)
CG5539 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea T19C3.4 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOP1 36
  • 20 (a)
Species with no ortholog for REEP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REEP3 Gene

Gene Tree for REEP3 (if available)
Gene Tree for REEP3 (if available)

Paralogs for REEP3 Gene

Paralogs for REEP3 Gene

Selected SIMAP similar genes for REEP3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with REEP3: view

Variants for REEP3 Gene

Sequence variations from dbSNP and Humsavar for REEP3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs15871 -- 63,621,018(+) TTTTT(A/T)TTTCC utr-variant-3-prime
rs1133386 -- 63,620,827(+) GGGTC(A/G)CTAAA reference, synonymous-codon
rs1255454 -- 63,622,958(+) cctcg(A/G)cctcc utr-variant-3-prime
rs1864390 -- 63,596,349(+) GTTCT(C/T)TTTTT intron-variant
rs1896994 -- 63,548,445(+) AAGAA(A/G)AGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for REEP3 Gene

Variant ID Type Subtype PubMed ID
nsv895571 CNV Loss 21882294
esv22964 CNV Loss 19812545
esv2334532 CNV Deletion 18987734
esv272741 CNV Insertion 20981092
esv2737640 CNV Deletion 23290073

Relevant External Links for REEP3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REEP3 Gene

Disorders for REEP3 Gene

Relevant External Links for REEP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with REEP3: view

No data available for UniProtKB/Swiss-Prot for REEP3 Gene

Publications for REEP3 Gene

  1. Identification and characterization of the TRIP8 and REEP3 genes on chromosome 10q21.3 as novel candidate genes for autism. (PMID: 17290275) Castermans D. … Devriendt K. (Eur. J. Hum. Genet. 2007) 3 4 23
  2. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H. … Matsunami H. (Cell 2004) 2 3 4
  3. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark A.J. … Huebner A. (Trends Endocrinol. Metab. 2005) 2 3
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  5. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PMID: 18940312) Yuan X. … Mooser V. (Am. J. Hum. Genet. 2008) 3 48

Products for REEP3 Gene

Sources for REEP3 Gene

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