Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

REEP2 Gene

protein-coding   GIFtS: 48
GCID: GC05P137774

Receptor Accessory Protein 2

(Previous name: chromosome 5 open reading frame 19)
(Previous symbol: C5orf19)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Receptor Accessory Protein 21 2
C5orf191 2 3 5
SGC324452 3
Chromosome 5 Open Reading Frame 191
Receptor Expression-Enhancing Protein 22

External Ids:    HGNC: 179751   Entrez Gene: 513082   Ensembl: ENSG000001325637   OMIM: 6093475   UniProtKB: Q9BRK03   

Export aliases for REEP2 gene to outside databases

Previous GC identifers: GC05P137803 GC05P132965


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for REEP2 Gene:
This gene encodes a member of the receptor expression enhancing protein family. Studies of a related gene in mouse
suggest that the encoded protein is found in the cell membrane and enhances the function of sweet taste
receptors. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2012)

GeneCards Summary for REEP2 Gene: 
REEP2 (receptor accessory protein 2) is a protein-coding gene. Diseases associated with REEP2 include systemic lupus erythematosus, and lupus erythematosus. GO annotations related to this gene include taste receptor binding. An important paralog of this gene is REEP1.

UniProtKB/Swiss-Prot: REEP2_HUMAN, Q9BRK0
Function: May enhance the cell surface expression of odorant receptors (By similarity)

Gene Wiki entry for REEP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the REEP2 gene promoter:
         ISGF-3   Bach2   Pax-2   IRF-1   Pax-2a   YY1   PPAR-alpha   ARP-1   Pax-4a   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREEP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for REEP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REEP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31

REEP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REEP2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P137774:  view genomic region     (about GC identifiers)

Start:
137,774,706 bp from pter      End:
137,782,658 bp from pter
Size:
7,953 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: REEP2_HUMAN, Q9BRK0 (See protein sequence)
Recommended Name: Receptor expression-enhancing protein 2  
Size: 252 amino acids; 28261 Da
Subunit: Interacts with odorant receptor proteins (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAF63767.1; Type=Frameshift; Positions=171;
Secondary accessions: Q53EM8 Q9NYF2
Alternative splicing: 2 isoforms:  Q9BRK0-1   Q9BRK0-2   

Explore the universe of human proteins at neXtProt for REEP2: NX_Q9BRK0

Explore proteomics data for REEP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BRK0

  • REEP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    REEP2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001258732.1  NP_057690.2  

    ENSEMBL proteins: 
     ENSP00000367590   ENSP00000254901   ENSP00000422530   ENSP00000424441   ENSP00000426658  

    Human Recombinant Protein Products for REEP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for REEP2
    OriGene Protein Over-expression Lysate for REEP2
    OriGene MassSpec for REEP2 
    OriGene Custom Protein Services for REEP2
    GenScript Custom Purified and Recombinant Proteins Services for REEP2
    Novus Biologicals REEP2 Proteins
    Novus Biologicals REEP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for REEP2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005881cytoplasmic microtubule IDA--
    GO:0005887integral to plasma membrane IEA--

    REEP2 for ontologies           About GeneDecksing



    REEP2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for REEP2
    OriGene Custom Antibody Services for REEP2
    GenScript Custom Superior Antibodies Services for REEP2
    Novus Biologicals REEP2 Antibodies
    Abcam antibodies for REEP2
    Cloud-Clone Corp. Antibodies for REEP2 
    ThermoFisher Antibodies for REEP2
    LSBio Antibodies in human, mouse, rat for REEP2 

    Assay Products for REEP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for REEP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for REEP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for REEP2 
    Cloud-Clone Corp. CLIAs for REEP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    REEP: Receptor accessory proteins

    1 InterPro protein domain:
     IPR004345 TB2_DP1_HVA22

    Graphical View of Domain Structure for InterPro Entry Q9BRK0

    ProtoNet protein and cluster: Q9BRK0

    1 Blocks protein domain: IPB004345 TB2/DP1 and HVA22 related proteins

    UniProtKB/Swiss-Prot: REEP2_HUMAN, Q9BRK0
    Similarity: Belongs to the DP1 family


    REEP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REEP2_HUMAN, Q9BRK0
    Function: May enhance the cell surface expression of odorant receptors (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031883taste receptor binding IEA--
         
    REEP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for REEP2:
     Increased Salmonella enterica   Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for REEP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for REEP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REEP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REEP2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REEP2
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate REEP2 (see all 21):
    hsa-miR-4291 hsa-miR-185* hsa-miR-1184 hsa-miR-124 hsa-miR-298 hsa-miR-320e hsa-miR-199b-5p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidREEP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for REEP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REEP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for REEP2
    Sirion Biotech Customized adenovirus for overexpression of REEP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for REEP2 (see all 8)
    OriGene ORF clones in mouse, rat for REEP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REEP2 (NM_016606)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REEP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP2
    Sirion Biotech Customized lentivirus for stable overexpression of REEP2 
                         Customized lentivirus expression plasmids for stable overexpression of REEP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for REEP2
    Search LifeMap BioReagents cell lines for REEP2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for REEP2

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032596protein transport into membrane raft IEA--
    GO:0050913sensory perception of bitter taste IEA--
    GO:0050916sensory perception of sweet taste IEA--

    REEP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for REEP2

    Search CenterWatch for drugs/clinical trials and news about REEP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for REEP2 gene (2 alternative transcripts): 
    NM_001271803.1  NM_016606.3  

    Unigene Cluster for REEP2:

    Receptor accessory protein 2
    Hs.416090  [show with all ESTs]
    Unigene Representative Sequence: NR_073449
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378339(uc003lda.3) ENST00000254901(uc003lcz.3 uc011cyt.2)
    ENST00000506158 ENST00000464751 ENST00000503379 ENST00000507511 ENST00000510467
    ENST00000512126 ENST00000507635 ENST00000504163
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat REEP2
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate REEP2 (see all 21):
    hsa-miR-4291 hsa-miR-185* hsa-miR-1184 hsa-miR-124 hsa-miR-298 hsa-miR-320e hsa-miR-199b-5p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidREEP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for REEP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REEP2
    Clone
    Products:
         
    OriGene clones in human, mouse for REEP2 (see all 8)
    OriGene ORF clones in mouse, rat for REEP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REEP2 (NM_016606)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REEP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP2
    Sirion Biotech Customized lentivirus for stable overexpression of REEP2 
                         Customized lentivirus expression plasmids for stable overexpression of REEP2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for REEP2
    OriGene qSTAR qPCR primer pairs in human, mouse for REEP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REEP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REEP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REEP2

    Additional mRNA sequence: 

    AF070551.1 AF251041.1 AK056193.1 AK223611.1 AK290547.1 AK291101.1 AK293480.1 AY562240.1 
    BC006218.2 BC148256.1 NR_073448.1 NR_073449.1 

    9 DOTS entries:

    DT.452490  DT.97845913  DT.95281545  DT.91749592  DT.95211241  DT.100791359  DT.100791360  DT.100683557 
    DT.91856239 

    24/140 AceView cDNA sequences (see all 140):

    AI969357 BM721217 BM544779 F09232 BM930666 BX441298 BP368695 CR609366 
    BM727106 BC006218 BX447028 NM_016606 AL537954 BM772986 AI337120 BM750298 
    BM745236 CB155164 CD675342 BM783702 BQ068211 BQ070092 CB153557 F11579 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for REEP2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
    SP1:                          -     -                 -           -           -                                       
    SP2:                          -     -                 -           -           -                                       
    SP3:                                -                 -           -           -                                       
    SP4:                                                  -           -           -                                       
    SP5:                          -     -                 -           -                                                   


    ECgene alternative splicing isoforms for REEP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    REEP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGAACGGG
    REEP2 Expression
    About this image


    See REEP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for REEP2

    SOURCE GeneReport for Unigene cluster: Hs.416090

    UniProtKB/Swiss-Prot: REEP2_HUMAN, Q9BRK0
    Tissue specificity: Detected in brain, heart and skeletal muscle, and at low levels in placenta, kidney and
    pancreas

        SABiosciences Custom PCR Arrays for REEP2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for REEP2
    OriGene qSTAR qPCR primer pairs in human, mouse for REEP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat REEP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REEP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REEP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for REEP2 gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Reep21 , 5 receptor accessory protein 21, 5 89.15(n)1
    92.86(a)1
      18 (18.75 cM)5
    2253621  NM_144865.21  NP_659114.21 
     348405895 
    chicken
    (Gallus gallus)
    Aves REEP21 receptor accessory protein 2 72.9(n)
    82.11(a)
      771891  XM_001234439.2  XP_001234440.2 
    lizard
    (Anolis carolinensis)
    Reptilia REEP26
    receptor accessory protein 2
    71(a)
    1 ↔ 1
    2(146640103-146665251)
    zebrafish
    (Danio rerio)
    Actinopterygii reep21 receptor accessory protein 2 67.06(n)
    69.05(a)
      568927  NM_001030227.1  NP_001025398.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG426781 CG42678 52.84(n)
    45.64(a)
      37643  NM_166575.2  NP_726270.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T19C3.41 Protein T19C3.4 50.45(n)
    45.05(a)
      175216  NM_064820.2  NP_497221.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YOP16
    Membrane protein that interacts with Yip1p to medi...
    18(a)
    1 → many
    XVI(623527-624202)


    ENSEMBL Gene Tree for REEP2 (if available)
    TreeFam Gene Tree for REEP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for REEP2 gene
    REEP12  REEP42  REEP32  REEP52  REEP62  
    5 SIMAP similar genes for REEP2 using alignment to 6 protein entries:     REEP2_HUMAN (see all proteins):
    REEP1    REEP4    REEP3    REEP5    REEP6

    REEP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/190 SNPs in REEP2 are shown (see all 190)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs758384931,2
    F--137773251(+) GGAGAG/AGAAGT 4 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1512609441,2
    --137773298(+) TTTCTA/GGAACG 4 -- us2k10--------
    rs772549881,2
    C,F--137773349(+) TAATTT/GACCAG 4 -- us2k11Minor allele frequency- G:0.02WA 118
    rs126590341,2
    C,F,A,H--137773525(+) AAGCTC/TTAAAA 4 -- us2k120Minor allele frequency- T:0.41NS EA WA NA CSA 2337
    rs1874421111,2
    --137773549(+) GAGAGC/TAATAG 4 -- us2k10--------
    rs1404368801,2
    --137773796(+) CAAAGC/GTTAGG 4 -- us2k10--------
    rs752637761,2
    C--137773943(+) TTGGC-/AAAAAA 4 -- us2k10--------
    rs594129291,2
    C--137773952(+) AAAAA-/A/AA  
            
    CAAAA
    4 -- us2k10--------
    rs1117242511,2
    C--137773954(+) AAAACAAAA/-  
            
    AACAA
    4 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1911289501,2
    --137774040(+) ATTCAA/GGCCCA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for REEP2 (137774706 - 137782658 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for REEP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5024CNV Insertion18451855
    nsv528851CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing REEP2
    DNA2.0 Custom Variant and Variant Library Synthesis for REEP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609347    OMIM disorders: --

    6 diseases for REEP2:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    kaposi's sarcoma    hypertension
    sarcoma    breast cancer


    REEP2 for disorders           About GeneDecksing


    Export disorders for REEP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for REEP2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with REEP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RTP family members induce functional expression of mammalian odorant receptors. (PubMed id 15550249)1, 2, 3 Saito H....Matsunami H. (2004)
    2. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PubMed id 16271481)1, 3 Clark A.J....Huebner A. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). (PubMed id 11161817)1, 2 Lai F.... Le Beau M.M. (2001)
    5. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (2012)
    6. REEP2 enhances sweet receptor function by recruitment to lipid rafts. (PubMed id 20943918)1 Ilegems E....Margolskee R.F. (2010)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
    10. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51308 HGNC: 17975 AceView: C5orf19 Ensembl:ENSG00000132563 euGenes: HUgn51308
    ECgene: REEP2 H-InvDB: REEP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for REEP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for REEP2 gene:
    Search GeneIP for patents involving REEP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for REEP2   OriGene RNAi products in human, mouse, rat for REEP2  
     OriGene qPCR primer pairs and template standards for REEP2   OriGene Protein Over-expression Lysate for REEP2  
     OriGene MassSpec something-or-other for REEP2   OriGene clones in human, mouse for REEP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for REEP2   OriGene Purified Protein for REEP2  
     OriGene ORF clones in mouse, rat for REEP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for REEP2   OriGene Custom Protein Services for REEP2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat REEP2
     QIAGEN SeqTarget long-range PCR primers for resequencing REEP2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat REEP2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat REEP2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat REEP2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat REEP2
     GenScript Custom Purified and Recombinant Proteins Services for REEP2 GenScript cDNA clones with any tag delivered in your preferred vector for REEP2
     GenScript Custom Assay Services for REEP2 GenScript Custom Superior Antibodies Services for REEP2
     GenScript Custom overexpressing Cell Line Services for REEP2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in REEP2 promoter
     Search Chromatin IP Primers for REEP2
     RT2 qPCR Primer Assay in human, mouse, rat REEP2
     Search GNC Networks for REEP2
     SABiosciences Custom PCR Arrays for REEP2
     Search Tocris compounds for REEP2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     REEP2 antibodies
     REEP2 proteins
     REEP2 lysates
     Antibodies for REEP2
     See all of Abcam's Antibodies, Kits and Proteins for REEP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for REEP2
     Antibodies for REEP2
     ELISAs for REEP2
     CLIAs for REEP2
     Search LifeMap BioReagents cell lines for REEP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP2
     SwitchGear 3'UTR luciferase reporter plasmids for REEP2
     SwitchGear Promoter luciferase reporter plasmids for REEP2
     ThermoFisher Antibodies for REEP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for REEP2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for REEP2
    Customized:
     lentivirus for stable overexpression of REEP2
     lentivirus expression plasmids for stable overexpression of REEP2
     adenovirus for overexpression of REEP2
     LSBio Antibodies in human, mouse, rat for REEP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      REEP2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4