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REEP2 Gene

protein-coding   GIFtS: 50
GCID: GC05P137774

Receptor Accessory Protein 2

(Previous name: chromosome 5 open reading frame 19)
(Previous symbol: C5orf19)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Receptor Accessory Protein 21 2
C5orf191 2 3 5
SGC324452 3
SPG722 5
Chromosome 5 Open Reading Frame 191
Receptor Expression-Enhancing Protein 22

External Ids:    HGNC: 179751   Entrez Gene: 513082   Ensembl: ENSG000001325637   OMIM: 6093475   UniProtKB: Q9BRK03   

Export aliases for REEP2 gene to outside databases

Previous GC identifers: GC05P137803 GC05P132965


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for REEP2 Gene:
This gene encodes a member of the receptor expression enhancing protein family. Studies of a related gene in mouse
suggest that the encoded protein is found in the cell membrane and enhances the function of sweet taste
receptors. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2012)

GeneCards Summary for REEP2 Gene:
REEP2 (receptor accessory protein 2) is a protein-coding gene. Diseases associated with REEP2 include kaposi's sarcoma, and systemic lupus erythematosus. GO annotations related to this gene include taste receptor binding. An important paralog of this gene is REEP4.

UniProtKB/Swiss-Prot: REEP2_HUMAN, Q9BRK0
Function: May enhance the cell surface expression of odorant receptors (By similarity)

Gene Wiki entry for REEP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the REEP2 gene promoter:
         ISGF-3   Bach2   Pax-2   IRF-1   Pax-2a   YY1   PPAR-alpha   ARP-1   Pax-4a   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREEP2 promoter sequence
   Search Chromatin IP Primers for REEP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REEP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31

REEP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REEP2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P137774:  view genomic region     (about GC identifiers)

Start:
137,774,706 bp from pter      End:
137,782,658 bp from pter
Size:
7,953 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: REEP2_HUMAN, Q9BRK0 (See protein sequence)
Recommended Name: Receptor expression-enhancing protein 2  
Size: 252 amino acids; 28261 Da
Subunit: Interacts with odorant receptor proteins (By similarity)
Sequence caution: Sequence=AAF63767.1; Type=Frameshift; Positions=171;
Secondary accessions: Q53EM8 Q9NYF2
Alternative splicing: 2 isoforms:  Q9BRK0-1   Q9BRK0-2   

Explore the universe of human proteins at neXtProt for REEP2: NX_Q9BRK0

Explore proteomics data for REEP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See REEP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258732.1  NP_057690.2  

    ENSEMBL proteins: 
     ENSP00000367590   ENSP00000254901   ENSP00000422530   ENSP00000424441   ENSP00000426658  

    REEP2 Human Recombinant Protein Products:

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    Novus Biologicals REEP2 Proteins
    Novus Biologicals REEP2 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for REEP2

    REEP2 Antibody Products:

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    Abcam antibodies for REEP2
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    ThermoFisher Antibodies for REEP2
    LSBio Antibodies in human, mouse, rat for REEP2

    REEP2 Assay Products:

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    Cloud-Clone Corp. CLIAs for REEP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    REEP: Receptor accessory proteins

    1 InterPro protein domain:
     IPR004345 TB2_DP1_HVA22

    Graphical View of Domain Structure for InterPro Entry Q9BRK0

    ProtoNet protein and cluster: Q9BRK0

    1 Blocks protein domain: IPB004345 TB2/DP1 and HVA22 related proteins

    UniProtKB/Swiss-Prot: REEP2_HUMAN, Q9BRK0
    Similarity: Belongs to the DP1 family


    REEP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REEP2_HUMAN, Q9BRK0
    Function: May enhance the cell surface expression of odorant receptors (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031883taste receptor binding IEA--
         
    REEP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for REEP2:
     Increased Salmonella enterica   Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for REEP2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for REEP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for REEP2

    miRNA
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    miRTarBase miRNAs that target REEP2:
    hsa-mir-196a-5p (MIRT048176), hsa-mir-423-3p (MIRT042650)

    Block miRNA regulation of human, mouse, rat REEP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate REEP2 (see all 21):
    hsa-miR-4291 hsa-miR-185* hsa-miR-1184 hsa-miR-124 hsa-miR-298 hsa-miR-320e hsa-miR-199b-5p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidREEP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat REEP2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: REEP2 (NM_016606)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REEP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for REEP2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    REEP2_HUMAN, Q9BRK0: Membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular2
    plasma membrane2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005881cytoplasmic microtubule IDA--
    GO:0005887integral component of plasma membrane IEA--

    REEP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for REEP2
    Interactions:

        Search GeneGlobe Interaction Network for REEP2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for REEP2 (ENSP000002549014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YIF1AENSP000003660984STRING: ENSP00000366098
    YIF1BENSP000003434354STRING: ENSP00000343435
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032596protein transport into membrane raft IEA--
    GO:0050913sensory perception of bitter taste IEA--
    GO:0050916sensory perception of sweet taste IEA--

    REEP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for REEP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for REEP2 gene (2 alternative transcripts): 
    NM_001271803.1  NM_016606.3  

    Unigene Cluster for REEP2:

    Receptor accessory protein 2
    Hs.416090  [show with all ESTs]
    Unigene Representative Sequence: NR_073449
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378339(uc003lda.3) ENST00000254901(uc003lcz.3 uc011cyt.2)
    ENST00000506158 ENST00000464751 ENST00000503379 ENST00000507511 ENST00000510467
    ENST00000512126 ENST00000507635 ENST00000504163
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat REEP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate REEP2 (see all 21):
    hsa-miR-4291 hsa-miR-185* hsa-miR-1184 hsa-miR-124 hsa-miR-298 hsa-miR-320e hsa-miR-199b-5p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidREEP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for REEP2
    Predesigned siRNA for gene silencing in human, mouse, rat REEP2
    Clone
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    OriGene clones in human, mouse for REEP2 (see all 7)
    OriGene ORF clones in mouse, rat for REEP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: REEP2 (NM_016606)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for REEP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat REEP2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for REEP2
    OriGene qSTAR qPCR primer pairs in human, mouse for REEP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat REEP2
      QuantiTect SYBR Green Assays in human, mouse, rat REEP2
      QuantiFast Probe-based Assays in human, mouse, rat REEP2

    Additional mRNA sequence: 

    AF070551.1 AF251041.1 AK056193.1 AK223611.1 AK290547.1 AK291101.1 AK293480.1 AY562240.1 
    BC006218.2 BC148256.1 NR_073448.1 NR_073449.1 

    9 DOTS entries:

    DT.452490  DT.97845913  DT.95281545  DT.91749592  DT.95211241  DT.100791359  DT.100791360  DT.100683557 
    DT.91856239 

    Selected AceView cDNA sequences (see all 140):

    CD675342 F11579 CR609366 AL537954 BM750298 CB153557 BM544779 BM745236 
    BQ068211 BM721217 BX441298 AI969357 AA989271 BP368695 AI337120 CB155164 
    NM_016606 BX447028 BM727106 BE883098 BM772986 BM930666 F09232 BC006218 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for REEP2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
    SP1:                          -     -                 -           -           -                                       
    SP2:                          -     -                 -           -           -                                       
    SP3:                                -                 -           -           -                                       
    SP4:                                                  -           -           -                                       
    SP5:                          -     -                 -           -                                                   


    ECgene alternative splicing isoforms for REEP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    REEP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGAACGGG
    REEP2 Expression
    About this image


    REEP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Corneal Stroma
    REEP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REEP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.416090

    UniProtKB/Swiss-Prot: REEP2_HUMAN, Q9BRK0
    Tissue specificity: Detected in brain, heart and skeletal muscle, and at low levels in placenta, kidney and
    pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REEP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for REEP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Reep21 , 5 receptor accessory protein 21, 5 89.24(n)1
    92.91(a)1
      18 (18.75 cM)5
    2253621  NM_144865.21  NP_659114.21 
     348405895 
    chicken
    (Gallus gallus)
    Aves REEP21 receptor accessory protein 2 72.98(n)
    82.26(a)
      771891  XM_001234439.3  XP_001234440.2 
    lizard
    (Anolis carolinensis)
    Reptilia REEP26
    receptor accessory protein 2
    72(a)
    1 ↔ 1
    2(146640103-146665251)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia reep21 receptor accessory protein 2 68.77(n)
    75.49(a)
      100037847  NM_001097293.1  NP_001090762.1 
    zebrafish
    (Danio rerio)
    Actinopterygii reep21 receptor accessory protein 2 67.99(n)
    70.63(a)
      568927  NM_001030227.1  NP_001025398.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG426781 CG42678 67.45(n)
    65.35(a)
      37643  NM_001103955.3  NP_001097425.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T19C3.41 T19C3.4 55.63(n)
    56.29(a)
      175216  NM_064820.3  NP_497221.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YOP16
    Membrane protein that interacts with Yip1p to medi...
    20(a)
    1 → many
    XVI(623527-624202) YPR028W


    ENSEMBL Gene Tree for REEP2 (if available)
    TreeFam Gene Tree for REEP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for REEP2 gene
    REEP42  REEP12  REEP32  REEP52  REEP62  
    5 SIMAP similar genes for REEP2 using alignment to 6 protein entries:     REEP2_HUMAN (see all proteins):
    REEP1    REEP4    REEP3    REEP5    REEP6

    REEP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for REEP2 (see all 190)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs758384931,2
    F--137773251(+) GGAGAG/AGAAGT 4 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1512609441,2
    --137773298(+) TTTCTA/GGAACG 4 -- us2k10--------
    rs772549881,2
    C,F--137773349(+) TAATTT/GACCAG 4 -- us2k11Minor allele frequency- G:0.02WA 118
    rs126590341,2
    C,F,A,H--137773525(+) AAGCTC/TTAAAA 4 -- us2k120Minor allele frequency- T:0.41NS EA WA NA CSA 2337
    rs1874421111,2
    --137773549(+) GAGAGC/TAATAG 4 -- us2k10--------
    rs1404368801,2
    --137773796(+) CAAAGC/GTTAGG 4 -- us2k10--------
    rs752637761,2
    C--137773943(+) TTGGC-/AAAAAA 4 -- us2k10--------
    rs594129291,2
    C--137773952(+) AAAAA-/A/AA  
            
    CAAAA
    4 -- us2k10--------
    rs1117242511,2
    C--137773954(+) AAAACAAAA/-  
            
    AACAA
    4 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1911289501,2
    --137774040(+) ATTCAA/GGCCCA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for REEP2 (137774706 - 137782658 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for REEP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5024CNV Insertion18451855
    nsv528851CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing REEP2
    DNA2.0 Custom Variant and Variant Library Synthesis for REEP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609347   
    OMIM disorders: 615625  
    6 diseases for REEP2:    
    About MalaCards
    kaposi's sarcoma    systemic lupus erythematosus    lupus erythematosus    sarcoma
    hypertension    breast cancer


    REEP2 for disorders           About GeneDecksing


    Export disorders for REEP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for REEP2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with REEP2)
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    1. RTP family members induce functional expression of mammalian odorant receptors. (PubMed id 15550249)1, 2, 3 Saito H.... Matsunami H. (Cell 2004)
    2. Loss of Association of REEP2 with Membranes Leads to Hereditary Spastic Paraplegia. (PubMed id 24388663)1, 3 Esteves T....Darios F. (Am. J. Hum. Genet. 2013)
    3. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PubMed id 16271481)1, 3 Clark A.J....Huebner A. (Trends Endocrinol. Metab. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). (PubMed id 11161817)1, 2 Lai F.... Le Beau M.M. (Genomics 2001)
    6. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (J. Virol. 2012)
    7. REEP2 enhances sweet receptor function by recruitment to lipid rafts. (PubMed id 20943918)1 Ilegems E....Margolskee R.F. (J. Neurosci. 2010)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (Genome Res. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51308 HGNC: 17975 AceView: C5orf19 Ensembl:ENSG00000132563 euGenes: HUgn51308
    ECgene: REEP2 H-InvDB: REEP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for REEP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for REEP2 gene:
    Search GeneIP for patents involving REEP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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