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RECQL4 Gene

protein-coding GIFtS: 69

GC08M145707

RecQ protein-like 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 3.6.1.- ^³
RECQ4 ^², ³, ⁵
RTS ^³, ⁵
RecQ4 ^¹, ³

Descriptions
RecQ protein 4 ^²
RecQ protein-like 4 ^², ³

External Ids
HGNC: 9949¹
Entrez Gene: 9401²
UniProtKB: O94761³
Ensembl: ENSG00000160957⁷

Search outside databases for aliases for RECQL4 gene

Previous GC identifers: GC08M143300 GC08M145774 GC08M145341 GC08M145741

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RECQ4_HUMAN, O94761

Function: DNA-dependent ATPase. May modulate chromosome segregation

Gene Wiki entry for RECQL4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RECQL4 gene

Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3

RECQL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M145707: (about GC identifiers)

Start:	145,707,479 bp from pter
End:	145,714,008 bp from pter
Size:	6,530 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_037704.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RECQ4_HUMAN, O94761 (See protein sequence)

Recommended Name: ATP-dependent DNA helicase Q4

Size: 1208 amino acids; Da

Subunit: Interacts with UBR1 and UBR2

Subcellular location: Cytoplasm. Nucleus

Secondary accessions: Q3Y424 Q96DW2 Q96F55

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004251.2

ENSEMBL proteins:

ENSP00000301323

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RECQ4)
	Human Recombinant Proteins from Abnova (RECQL4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for RECQL4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RECQL4
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for RECQL4
	Antibodies from Abcam (RECQ4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RECQL4)
	Novus Biologicals Antibodies for RECQL4

Assays for RECQL4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O94761

ProtoNet protein and cluster: O94761

1 Blocks protein family: IPB002464 ATP-dependent helicase

UniProtKB/Swiss-Prot: RECQ4_HUMAN, O94761

Similarity: Belongs to the helicase family. RecQ subfamily

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RECQL4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RECQL4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004260

Applied Biosystems Silencer® siRNAs for RECQL4

Sigma-Aldrich siRNA and siRNA Panels for RECQL4

Sigma-Aldrich shRNA Panels and shRNA for RECQL4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RECQL4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004260
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004260
untagged cDNA clones in CMV expression vector (see all 3): BC013277

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004260

UniProtKB/Swiss-Prot: RECQ4_HUMAN, O94761

Function: DNA-dependent ATPase. May modulate chromosome segregation

Induction: Up-regulated in actively dividing cells

Enzyme Number (IUBMB): EC 3.6.1.-

Genatlas biochemistry entry for RECQL4:

DNA helicase ATP dependent,with E coli RecQ,expressed in thymus and testis as the BLM gene and

up-regulated at the G1/S and G2/M stage of the cell cycle,involved in the maintenance of genomic

integrity

15/16 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Recql4) (see all 16 ):

cellular	craniofacial	digestive/alimentary	embryogenesis	growth/size
hematopoietic system	immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging
limbs/digits/tail	pigmentation	skeleton	skin/coat/nails	tumorigenesis

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	IEA	--
GO:0003678	DNA helicase activity	TAS	9878247
GO:0005524	ATP binding	IEA	--
GO:0008026	ATP-dependent helicase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for RECQL4 (Your Favorite Gene powered by Ingenuity)

Inositol Metabolism

GeneDecks RECQL4 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for RECQL4

5/8 Interacting proteins for RECQL4 (ENSP00000301323³ O94761²) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRSS23	O95084²	MINT-63244
ENOSF1	ENSP00000313346³	STRING (score=.961)
TP53	ENSP00000269305³	STRING (score=.867)
EP300	ENSP00000263253³	STRING (score=.856)
UBR2	ENSP00000361992³	STRING (score=.797)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006281	DNA repair	TAS	9878247
GO:0006310	DNA recombination	IEA	--
GO:0007275	multicellular organismal development	TAS	10319867

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RECQL4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RECQL4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RECQL4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004260

Sigma-Aldrich siRNA and siRNA Panels for RECQL4

Sigma-Aldrich shRNA Panels and shRNA for RECQL4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004260

REFSEQ mRNAs for RECQL4 gene:

NM_004260.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004260

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004260
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004260
                                 untagged cDNA clones in CMV expression vector (see all 3): BC013277

Additional cDNA sequence:

AB006532.1 BC011602.2 BC013277.2 BC020496.2

10 DOTS entries:

DT.409421 DT.91829401 DT.121487236 DT.92425820 DT.100755281 DT.92030793 DT.102843665 DT.121487256

DT.95308835 DT.97813869

24/88 AceView cDNA sequences (see all 88 ):

AI341050 BM702983 BE466402 BU902971 BF513150 BE869080 BF909603 BC011602

BE513519 BQ215879 BM854499 AI590776 BC013277 BQ649577 CF619328 BG337750

BQ065027 BM557643 BE378846 BU902969 AL582326 BM763376 BQ218075 BG398209

highest scoring ESTs for RECQL4:

AB006532 AA768048 AA984927 AI590776 AI765149 AI858255 AI872334 AI886385 AW236527 BC011602

Unigene Cluster for RECQL4:

RecQ protein-like 4

Hs.31442 [show with all ESTs]

Unigene Representative Sequence: BC020496

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RECQL4 (see all 8 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14	^	15a	·
SP1:			-		-								-
SP2:																															-
SP3:
SP4:													-		-		-
SP5:													-		-

ExUns:	15b	·	15c	^	16	^	17a	·	17b	^	18	^	19	^	20a	·	20b	·	20c
SP1:							-
SP2:
SP3:					-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for RECQL4

1 Ensembl transcript including schematic representation:

ENST00000301323

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RECQL4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RECQL4

¹ / ² / ³

6 probe-sets matching RECQL4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39651_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.78	AB006532	1.00	1.00	1.00	1
55130_f_at²^{, 3}	U95-C	1	0.62	1.00	0.98	1.22	AI206129	0.20	1.00	0.72	1
55127_i_at²^{, 3}	U95-C	1	0.39	1.00	0.33	0.40	AI206129	0.20	1.00	0.72	1
213520_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004260	0.60	1.00	0.82	1
213520_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1553015_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks RECQL4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCTGGTGGG

SOURCE GeneReport for Unigene cluster: Hs.31442
Expression variation in blood from EXPOLDB for RECQL4
UniProtKB/Swiss-Prot: RECQ4_HUMAN, O94761
Tissue specificity: Ubiquitously expressed, with highest levels in thymus and testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RECQL4 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RECQL4¹	--	RecQ protein-like 4	74.8(n) 68.21(a)	482101 XM_539222.2 XP_539222.2
chimpanzee (Pan troglodytes)	RECQL4¹	--	RecQ protein-like 4	98.73(n) 98.18(a)	464469 XM_520023.2 XP_520023.2
cow (Bos taurus)	RECQL4¹	--	RecQ protein-like 4	76.35(n) 69.85(a)	515472 XM_593498.3 XP_593498.3
rat (Rattus norvegicus)	Recql4¹	--	RecQ protein-like 4	74.41(n) 69.15(a)	300057 XM_216973.4 XP_216973.4
mouse (Mus musculus)	Recql4^{1, 5}	15⁵	RecQ protein-like 4^{1, 5}	73.33(n)¹ 67.86(a)¹	79456¹ NM_058214.2¹ NP_478121.2¹ AB039882⁵ AB042528⁵ (see all 12)

About this table Species with no ortholog for RECQL4

ENSEMBL Gene Tree for RECQL4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RECQL4 gene

RECQL5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/74 NCBI SNPs in RECQL4 are shown (see all 74 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 115)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2721191^1,2	C,F	145710487(-)	`CCTCCC/TTCCAG`	1	P/L	mis¹ ese³		5	NS	188
	rs4251691^1,2	C,F	145708624(-)	`GCGGCG/AGGCTC`	1	Q/R	mis¹ ese³		5	NS	188
	rs35101495^1,2	F	145708158(-)	`AGGAAG/CGGCAG`	1	R/G	mis¹		5	NS	188
--	rs35407712^1,2	F	145711184(-)	`GCCGGC/TGCAGC`	1	R/C	mis¹		5	NS	190
	rs35842750^1,2	F	145711183(-)	`CCGGCG/ACAGCC`	1	H/R	mis¹		5	NS	190
--	rs36023964^1,2	F	145708628(-)	`CTGTGC/TGGCGG`	1	R/W	mis¹		5	NS	184
	rs35098923^1,2	F	145709495(-)	`TGCCCC/TCAAGC`	1	P/S	mis¹		5	NS	190
--	rs34293591^1,2	F	145709477(-)	`GCTACG/ATGCAG`	1	M/V	mis¹		5	NS	190
	rs35348691^1,2	F	145708438(-)	`TGACCG/ACTGAG`	1	T/A	mis¹		5	NS	182
--	rs34915097^1,2	F	145708182(-)	`TGCTCG/AGCCGC`	1	S/G	mis¹		5	NS	188

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HapMap Linkage Disequilibrium images for RECQL4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603780 disorders: 268400 266280 218600

UniProtKB/Swiss-Prot: RECQ4_HUMAN, O94761

Defects in RECQL4 are a cause of Rothmund-Thomson syndrome (RTS) [MIM:268400]. A disease

characterized by dermatological features such as atrophy, pigmentation, and telangiectasia and

frequently accompanied by juvenile cataract, saddle nose, congenital bone defects, disturbances of

hair growth, and hypogonadism

Defects in RECQL4 are a cause of RAPADILINO syndrome [MIM:266280]. A disease characterized

by radial and patellar aplasia or hypoplasia

Defects in RECQL4 are a cause of Baller-Gerold syndrome (BGS) [MIM:218600]; also known as

craniosynostosis with radial defects. BGS is an autosomal recessive syndrome characterized by

short stature, craniosynostosis, absent or hypoplastic radii, short and curved ulna, fused carpal

bones and absent carpals, metacarpals and phalanges. Some patients manifest poikiloderma. Cases

reported as Baller-Gerold syndrome have phenotypic overlap with several other disorders, including

Saethre-Chotzen syndrome. BGS is part of the clinical spectrum of Rothmund-Thomson and RAPADILINO

syndromes

10/17 Novoseek disease relationships for RECQL4 gene (see all 17 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rothmund-thomson syndrome	98.68	39	12218919 (2), 15960976 (2), 10552928 (2), 19177149 (2) (see all 31)
rapadilino syndrome	98.03	7	15964893 (2), 15317757 (2), 17250975 (1), 19291770 (1)
baller-gerold syndrome	94.14	8	19299466 (1), 17250975 (1), 17364146 (1), 15964893 (1) (see all 6)
bloom syndrome	90.93	9	15702347 (1), 16793396 (1), 17623900 (1), 18719387 (1) (see all 9)
werner syndrome	89.59	11	15702347 (1), 16271439 (1), 16793396 (1), 16949575 (1) (see all 11)
small stature	75.77	1	16630167 (1)
osteosarcoma	59.18	13	12734318 (4), 15221963 (2), 17264332 (1), 18647888 (1) (see all 8)
craniosynostosis	57.54	1	19022412 (1)
genetic disorder	55.92	2	10552928 (1), 11032027 (1)
growth retardation	54.64	1	15317757 (1)

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GeneTests: RECQL4

Baller-Gerold Syndrome

Human Gene Mutation Database: RECQL4
Genetic Association Database: RECQL4
Human Genome Epidemiology Navigator: RECQL4 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/76 PubMed articles for RECQL4 gene (see all 76 ):

Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes. (PubMed id 9878247)^{1, 2, 3, 4} Kitao S.... Shimamoto A. (1998)
Rothmund-Thomson syndrome responsible gene, RECQL4: genomic structure and products. (PubMed id 10552928)^{1, 3, 4} Kitao S.... Shimamoto A. (1999)
RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. (PubMed id 15317757)^{1, 3, 4} Yin J.... Wang W. (2004)
Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome. (PubMed id 12734318)^{1, 3, 6} Wang L.L....Plon S.E. (2003)
Mutation analysis of the RECQL4 gene in sporadic osteosarcomas. (PubMed id 15221963)^{1, 3, 4} Nishijo K.... Toguchida J. (2004)
Revisiting the craniosynostosis-radial ray hypoplasia association: Baller-Gerold syndrome caused by mutations in the RECQL4 gene. (PubMed id 15964893)^{1, 3, 4} Van Maldergem L.... Verloes A. (2006)
Identification of two novel RECQL4exonic SNPs and genomic characterization of the IVS12 minisatellite. (PubMed id 12601557)^{1, 3, 4} Roversi G.... Larizza L. (2003)
Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome. (PubMed id 15960976)^{1, 2, 3} Sangrithi M.N....Venkitaraman A.R. (2005)
Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases. (PubMed id 12952869)^{1, 3, 4} Siitonen H.A.... Kestilae M. (2003)
Differential regulation of human RecQ family helicases in cell transformation and cell cycle. (PubMed id 11032027)^{1, 3, 4} Kawabe T.... Sugimoto M. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9401	HGNC: 9949	AceView: RECQL4	Ensembl:ENSG00000160957	euGenes: HUgn9401
ECgene: RECQL4	H-InvDB: RECQL4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RECQL4	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=RECQL4
NIEHS-SNPs	http://egp.gs.washington.edu/data/recql4/

Licensable Technologies for RECQL4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RECQL4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RECQL4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RECQL4		Antibodies for RECQL4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RECQL4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RECQL4)
	Antibodies (RECQL4)
	Chimera RNAi (RECQL4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for RECQL4

	Recombinant Proteins (RECQ4)
	Antibodies (RECQ4)

Search OriGene for RECQL4

Search Tocris compounds for RECQL4

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Antibodies for RECQL4

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RECQL4 Gene at Home site.
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RECQL4 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for RECQL4

Summaries
for RECQL4

Genomic Location
for RECQL4

Proteins
for RECQL4

Protein Domains/
Families
for RECQL4

Gene Function
for RECQL4

Pathways & Interactions
for RECQL4

Drugs & Compounds
for RECQL4

Transcripts
for RECQL4

Expression
for RECQL4

Orthologs
for RECQL4

Paralogs
for RECQL4

SNPs/Variants
for RECQL4

Disorders & Mutations
for RECQL4

Medical News
for RECQL4

Publications
for RECQL4

Search for RECQL4

Genome Databases showing RECQL4

Other Databases showing RECQL4

Specialized Databases showing RECQL4

Licensable Technologies
for RECQL4

Services
for RECQL4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RECQL4 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor RECQL4

Summariesfor RECQL4

Genomic Locationfor RECQL4

Proteinsfor RECQL4

Protein Domains/Familiesfor RECQL4

Gene Functionfor RECQL4

Pathways & Interactionsfor RECQL4

Drugs & Compoundsfor RECQL4

Transcriptsfor RECQL4

Expression for RECQL4

Orthologsfor RECQL4

Paralogsfor RECQL4

SNPs/Variantsfor RECQL4

Disorders & Mutationsfor RECQL4

Medical Newsfor RECQL4

Publicationsfor RECQL4

Search for RECQL4

Genome Databases showing RECQL4

Other Databases showing RECQL4

Specialized Databases showing RECQL4

Licensable Technologiesfor RECQL4

Servicesfor RECQL4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RECQL4

Summaries
for RECQL4

Genomic Location
for RECQL4

Proteins
for RECQL4

Protein Domains/
Families
for RECQL4

Gene Function
for RECQL4

Pathways & Interactions
for RECQL4

Drugs & Compounds
for RECQL4

Transcripts
for RECQL4

Expression
for RECQL4

Orthologs
for RECQL4

Paralogs
for RECQL4

SNPs/Variants
for RECQL4

Disorders & Mutations
for RECQL4

Medical News
for RECQL4

Publications
for RECQL4

Licensable Technologies
for RECQL4

Services
for RECQL4