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Aliases for RECK Gene

Aliases for RECK Gene

  • Reversion Inducing Cysteine Rich Protein With Kazal Motifs 2 3 5
  • Suppressor Of Tumorigenicity 15 Protein 3 4
  • ST15 3 4
  • Suppression Of Tumorigenicity 15 (Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs) 3
  • Suppression Of Tumorigenicity 5 (Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs) 3
  • Reversion-Inducing Cysteine-Rich Protein With Kazal Motifs 3
  • Membrane-Anchored Glycoprotein (Metastasis And Invasion) 3
  • HRECK 4

External Ids for RECK Gene

Previous HGNC Symbols for RECK Gene

  • ST15

Previous GeneCards Identifiers for RECK Gene

  • GC09P036349
  • GC09P036206
  • GC09P036026
  • GC09P035990

Summaries for RECK Gene

Entrez Gene Summary for RECK Gene

  • The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for RECK Gene

RECK (Reversion Inducing Cysteine Rich Protein With Kazal Motifs) is a Protein Coding gene. Diseases associated with RECK include Middle Ear Squamous Cell Carcinoma and Middle Ear Carcinoma. Among its related pathways are Angiogenesis (CST) and MicroRNAs in cancer. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.

UniProtKB/Swiss-Prot for RECK Gene

  • Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.

Gene Wiki entry for RECK Gene

Additional gene information for RECK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RECK Gene

Genomics for RECK Gene

Regulatory Elements for RECK Gene

Enhancers for RECK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H035656 1.7 Ensembl ENCODE dbSUPER 11.5 -375.5 -375468 9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ARHGEF39 VCP RGP1 C9orf131 PIGO RN7SL22P NPR2 YBX1P10 RECK ENSG00000230074
GH09H036035 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +2.1 2050 5 SIN3A FEZF1 BRCA1 GLIS2 SCRT2 FOS RCOR1 SP3 ZNF362 NFYC RECK GLIPR2 ATP8B5P OR2S2 ENSG00000276730
GH09H035913 1.5 Ensembl ENCODE dbSUPER 11.6 -119.2 -119192 7 HDGF ATF1 ARNT ARID4B YBX1 ZBTB7B YY1 TCF12 ZNF766 ELK1 PIGO ARHGEF39 RGP1 TLN1 GBA2 SPAAR CLTA RECK NDUFA5P4 OR13J1
GH09H036147 1.3 Ensembl ENCODE dbSUPER 9.8 +112.2 112184 2 TBL1XR1 NFIB JUN BATF FOSL1 LCORL POLR2A EED PATZ1 FOS CCIN CLTA ZCCHC7 RECK GLIPR2 GNE
GH09H036073 0.9 Ensembl ENCODE 8.9 +38.1 38146 1 NFIA MAX FEZF1 RAD21 KDM1A FOXJ2 PRDM1 TRIM28 GLIPR2 GNE RECK ENSG00000276730
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RECK on UCSC Golden Path with GeneCards custom track

Promoters for RECK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234733 967 1601 SIN3A FEZF1 BRCA1 GLIS2 SCRT2 RCOR1 SP3 ZNF362 NFYC GLIS1

Genomic Location for RECK Gene

Chromosome:
9
Start:
36,036,433 bp from pter
End:
36,124,455 bp from pter
Size:
88,023 bases
Orientation:
Plus strand

Genomic View for RECK Gene

Genes around RECK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RECK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RECK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RECK Gene

Proteins for RECK Gene

  • Protein details for RECK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95980-RECK_HUMAN
    Recommended name:
    Reversion-inducing cysteine-rich protein with Kazal motifs
    Protein Accession:
    O95980
    Secondary Accessions:
    • B2RNS1
    • Q5W0K6
    • Q8WX37

    Protein attributes for RECK Gene

    Size:
    971 amino acids
    Molecular mass:
    106457 Da
    Quaternary structure:
    • Interacts with MMP-9.

neXtProt entry for RECK Gene

Post-translational modifications for RECK Gene

  • N-glycosylated.
  • Glycosylation at isoforms=39, isoforms=86, isoforms=200, isoforms=297, and Asn352
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RECK Gene

Domains & Families for RECK Gene

Gene Families for RECK Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for RECK Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RECK Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RECK: view

No data available for UniProtKB/Swiss-Prot for RECK Gene

Function for RECK Gene

Molecular function for RECK Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.

Phenotypes From GWAS Catalog for RECK Gene

Gene Ontology (GO) - Molecular Function for RECK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity IDA 9789069
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 21255571
GO:0008191 metalloendopeptidase inhibitor activity TAS 9789069
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with RECK: view
genes like me logo Genes that share phenotypes with RECK: view

Animal Models for RECK Gene

MGI Knock Outs for RECK:

Animal Model Products

CRISPR Products

miRNA for RECK Gene

miRTarBase miRNAs that target RECK

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RECK
  • Applied Biological Materials Clones for RECK
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RECK Gene

Localization for RECK Gene

Subcellular locations from UniProtKB/Swiss-Prot for RECK Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RECK gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RECK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 9789069
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with RECK: view

Pathways & Interactions for RECK Gene

genes like me logo Genes that share pathways with RECK: view

Pathways by source for RECK Gene

1 KEGG pathway for RECK Gene
1 Qiagen pathway for RECK Gene

Gene Ontology (GO) - Biological Process for RECK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001955 blood vessel maturation IEA --
GO:0006501 C-terminal protein lipidation TAS --
GO:0007566 embryo implantation IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with RECK: view

No data available for SIGNOR curated interactions for RECK Gene

Drugs & Compounds for RECK Gene

(37) Drugs for RECK Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(32) Additional Compounds for RECK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RECK: view

Transcripts for RECK Gene

Unigene Clusters for RECK Gene

Reversion-inducing-cysteine-rich protein with kazal motifs:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RECK
  • Applied Biological Materials Clones for RECK
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RECK Gene

No ASD Table

Relevant External Links for RECK Gene

GeneLoc Exon Structure for
RECK
ECgene alternative splicing isoforms for
RECK

Expression for RECK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RECK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RECK Gene

This gene is overexpressed in Plasma (11.0), Skin (9.7), Cerebral cortex (8.6), and Serum (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RECK Gene



NURSA nuclear receptor signaling pathways regulating expression of RECK Gene:

RECK

SOURCE GeneReport for Unigene cluster for RECK Gene:

Hs.388918

mRNA Expression by UniProt/SwissProt for RECK Gene:

O95980-RECK_HUMAN
Tissue specificity: Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.

Evidence on tissue expression from TISSUES for RECK Gene

  • Lung(4.4)
  • Intestine(2)
genes like me logo Genes that share expression patterns with RECK: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RECK Gene

Orthologs for RECK Gene

This gene was present in the common ancestor of animals.

Orthologs for RECK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RECK 33 34
  • 99.9 (n)
dog
(Canis familiaris)
Mammalia RECK 33 34
  • 92.34 (n)
cow
(Bos Taurus)
Mammalia RECK 33 34
  • 91.59 (n)
oppossum
(Monodelphis domestica)
Mammalia RECK 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RECK 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Reck 33 16 34
  • 87.96 (n)
rat
(Rattus norvegicus)
Mammalia Reck 33
  • 87.35 (n)
chicken
(Gallus gallus)
Aves RECK 33 34
  • 80.36 (n)
lizard
(Anolis carolinensis)
Reptilia RECK 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia reck 33
  • 72.66 (n)
zebrafish
(Danio rerio)
Actinopterygii RECK 34
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Reck 33 34
  • 47.08 (n)
CG5392 35
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010646 33
  • 46.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToOne
Species where no ortholog for RECK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RECK Gene

ENSEMBL:
Gene Tree for RECK (if available)
TreeFam:
Gene Tree for RECK (if available)

Paralogs for RECK Gene

No data available for Paralogs for RECK Gene

Variants for RECK Gene

Sequence variations from dbSNP and Humsavar for RECK Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000008795 -- 36,083,830(+) GTTGG(G/T)TAATG intron-variant
rs1000012615 -- 36,098,243(+) TAAGT(A/G)TGTGA intron-variant
rs1000036547 -- 36,076,884(+) AAAAA(A/C)AACCC intron-variant
rs1000071334 -- 36,036,568(+) GAAGC(C/G)CCTTT upstream-variant-2KB
rs1000089801 -- 36,111,533(+) GGAAC(A/G)ACAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RECK Gene

Variant ID Type Subtype PubMed ID
esv34080 CNV loss 18971310
nsv1017711 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv478248 CNV novel sequence insertion 20440878
nsv831546 CNV loss 17160897
nsv831547 CNV loss 17160897

Variation tolerance for RECK Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.99; 80.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RECK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RECK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RECK Gene

Disorders for RECK Gene

MalaCards: The human disease database

(8) MalaCards diseases for RECK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
middle ear squamous cell carcinoma
  • epidermoid carcinoma of the middle ear
middle ear carcinoma
  • carcinoma of middle ear
wolfram syndrome
  • wolfram syndrome 1
quebec platelet disorder
  • bdplt5
binswanger's disease
  • dementia multi-infarct
- elite association - COSMIC cancer census association via MalaCards
Search RECK in MalaCards View complete list of genes associated with diseases

Relevant External Links for RECK

Genetic Association Database (GAD)
RECK
Human Genome Epidemiology (HuGE) Navigator
RECK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RECK
genes like me logo Genes that share disorders with RECK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RECK Gene

Publications for RECK Gene

  1. Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. (PMID: 9789069) Takahashi C … Noda M (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22 60
  2. Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. (PMID: 17033924) Lei H … Försti A (Breast cancer research and treatment 2007) 3 22 45 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage. (PMID: 20395433) Kimura T … Okada Y (The American journal of pathology 2010) 3 22 60

Products for RECK Gene

  • Addgene plasmids for RECK

Sources for RECK Gene

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