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Aliases for RECK Gene

Aliases for RECK Gene

  • Reversion Inducing Cysteine Rich Protein With Kazal Motifs 2 3 5
  • Suppressor Of Tumorigenicity 15 Protein 3 4
  • ST15 3 4
  • Suppression Of Tumorigenicity 15 (Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs) 3
  • Suppression Of Tumorigenicity 5 (Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs) 3
  • Reversion-Inducing Cysteine-Rich Protein With Kazal Motifs 3
  • Membrane-Anchored Glycoprotein (Metastasis And Invasion) 3
  • HRECK 4

External Ids for RECK Gene

Previous HGNC Symbols for RECK Gene

  • ST15

Previous GeneCards Identifiers for RECK Gene

  • GC09P036349
  • GC09P036206
  • GC09P036026
  • GC09P035990

Summaries for RECK Gene

Entrez Gene Summary for RECK Gene

  • The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for RECK Gene

RECK (Reversion Inducing Cysteine Rich Protein With Kazal Motifs) is a Protein Coding gene. Diseases associated with RECK include Middle Ear Squamous Cell Carcinoma and Middle Ear Carcinoma. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.

UniProtKB/Swiss-Prot for RECK Gene

  • Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.

Gene Wiki entry for RECK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RECK Gene

Genomics for RECK Gene

Regulatory Elements for RECK Gene

Enhancers for RECK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F035913 0.5 Ensembl ENCODE 12 -119.3 -119283 7.9 HDGF PKNOX1 ATF1 ARNT ARID4B YBX1 ZNF48 YY1 ZNF766 ELK1 CREB3 SPAG8 YBX1P10 GBA2 LINC00961 RECK NDUFA5P4 FAM221B OR13J1 TMEM8B
GH09F035726 0.9 FANTOM5 ENCODE 11.5 -306.0 -306019 8.6 MLX CREB3L1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TMEM8B GBA2 TPM2 RGP1 TLN1 ARHGEF39 RN7SL22P CCDC107 ENSG00000228843 MSMP
GH09F035101 0.4 ENCODE 11.4 -933.2 -933222 3.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 PIGO CREB3 CCL21 RECK FANCG VCP ENSG00000230074 SPAG8 STOML2 FAM214B
GH09F035069 0.4 ENCODE 11.4 -964.5 -964539 4.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YY1 ZNF207 ZNF143 FOS VCP FANCG RECK ENSG00000228352 ENSG00000230074 PIGO RN7SL338P
GH09F036035 0.9 FANTOM5 ENCODE 10.6 +1.8 1817 4.6 SIN3A FEZF1 ZNF335 GLIS2 SCRT2 ZNF362 SP3 NFYC ZFP69B SMARCA4 RECK GLIPR2 ATP8B5P OR2S2 ENSG00000276730
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RECK on UCSC Golden Path with GeneCards custom track

Promoters for RECK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001302952 1367 2801 SIN3A FEZF1 ZNF335 GLIS2 SCRT2 ZNF362 SP3 NFYC REST SMARCA4

Genomic Location for RECK Gene

Chromosome:
9
Start:
36,036,433 bp from pter
End:
36,124,455 bp from pter
Size:
88,023 bases
Orientation:
Plus strand

Genomic View for RECK Gene

Genes around RECK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RECK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RECK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RECK Gene

Proteins for RECK Gene

  • Protein details for RECK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95980-RECK_HUMAN
    Recommended name:
    Reversion-inducing cysteine-rich protein with Kazal motifs
    Protein Accession:
    O95980
    Secondary Accessions:
    • B2RNS1
    • Q5W0K6
    • Q8WX37

    Protein attributes for RECK Gene

    Size:
    971 amino acids
    Molecular mass:
    106457 Da
    Quaternary structure:
    • Interacts with MMP-9.

neXtProt entry for RECK Gene

Post-translational modifications for RECK Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RECK (RECK)

No data available for DME Specific Peptides for RECK Gene

Domains & Families for RECK Gene

Protein Domains for RECK Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RECK Gene

Graphical View of Domain Structure for InterPro Entry

O95980

UniProtKB/Swiss-Prot:

RECK_HUMAN :
  • Contains 3 Kazal-like domains.
Domain:
  • Contains 3 Kazal-like domains.
genes like me logo Genes that share domains with RECK: view

No data available for Gene Families for RECK Gene

Function for RECK Gene

Molecular function for RECK Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.

Gene Ontology (GO) - Molecular Function for RECK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity IEA,IDA 9789069
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 21255571
GO:0008191 metalloendopeptidase inhibitor activity TAS 9789069
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with RECK: view
genes like me logo Genes that share phenotypes with RECK: view

Animal Models for RECK Gene

MGI Knock Outs for RECK:

Animal Model Products

miRNA for RECK Gene

miRTarBase miRNAs that target RECK

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RECK

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RECK Gene

Localization for RECK Gene

Subcellular locations from UniProtKB/Swiss-Prot for RECK Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RECK Gene COMPARTMENTS Subcellular localization image for RECK gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RECK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA,TAS 9789069
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with RECK: view

Pathways & Interactions for RECK Gene

genes like me logo Genes that share pathways with RECK: view

Pathways by source for RECK Gene

1 KEGG pathway for RECK Gene
1 Qiagen pathway for RECK Gene

Gene Ontology (GO) - Biological Process for RECK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001955 blood vessel maturation IEA --
GO:0007566 embryo implantation IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0030198 extracellular matrix organization IBA --
GO:0030336 negative regulation of cell migration IMP 18591254
genes like me logo Genes that share ontologies with RECK: view

No data available for SIGNOR curated interactions for RECK Gene

Drugs & Compounds for RECK Gene

(30) Drugs for RECK Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(39) Additional Compounds for RECK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RECK: view

Transcripts for RECK Gene

mRNA/cDNA for RECK Gene

(10) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RECK Gene

Reversion-inducing-cysteine-rich protein with kazal motifs:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RECK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RECK Gene

No ASD Table

Relevant External Links for RECK Gene

GeneLoc Exon Structure for
RECK
ECgene alternative splicing isoforms for
RECK

Expression for RECK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RECK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RECK Gene

This gene is overexpressed in Plasma (11.0), Skin (9.7), Cerebral cortex (8.6), and Serum (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RECK Gene



NURSA nuclear receptor signaling pathways regulating expression of RECK Gene:

RECK

SOURCE GeneReport for Unigene cluster for RECK Gene:

Hs.388918

mRNA Expression by UniProt/SwissProt for RECK Gene:

O95980-RECK_HUMAN
Tissue specificity: Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.
genes like me logo Genes that share expression patterns with RECK: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for RECK Gene

Orthologs for RECK Gene

This gene was present in the common ancestor of animals.

Orthologs for RECK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RECK 34 35
  • 99.9 (n)
dog
(Canis familiaris)
Mammalia RECK 34 35
  • 92.34 (n)
cow
(Bos Taurus)
Mammalia RECK 34 35
  • 91.59 (n)
oppossum
(Monodelphis domestica)
Mammalia RECK 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RECK 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Reck 34 16 35
  • 87.96 (n)
rat
(Rattus norvegicus)
Mammalia Reck 34
  • 87.35 (n)
chicken
(Gallus gallus)
Aves RECK 34 35
  • 80.36 (n)
lizard
(Anolis carolinensis)
Reptilia RECK 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia reck 34
  • 72.66 (n)
zebrafish
(Danio rerio)
Actinopterygii RECK 35
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Reck 34 35
  • 47.08 (n)
CG5392 36
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010646 34
  • 46.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToOne
Species where no ortholog for RECK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RECK Gene

ENSEMBL:
Gene Tree for RECK (if available)
TreeFam:
Gene Tree for RECK (if available)

Paralogs for RECK Gene

No data available for Paralogs for RECK Gene

Variants for RECK Gene

Sequence variations from dbSNP and Humsavar for RECK Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10115326 -- 36,092,683(+) cacca(C/G)gagtg intron-variant
rs10116037 -- 36,124,842(+) CCAGC(G/T)TTCAG downstream-variant-500B
rs10116121 -- 36,119,245(+) AGTAT(G/T)CAATT intron-variant
rs10116228 -- 36,093,753(+) CCTTA(A/G)TAAAC intron-variant
rs10117065 -- 36,055,528(+) gccct(G/T)gaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RECK Gene

Variant ID Type Subtype PubMed ID
esv34080 CNV loss 18971310
nsv1017711 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv478248 CNV novel sequence insertion 20440878
nsv831546 CNV loss 17160897
nsv831547 CNV loss 17160897

Variation tolerance for RECK Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.99; 80.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RECK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RECK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RECK Gene

Disorders for RECK Gene

MalaCards: The human disease database

(7) MalaCards diseases for RECK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
middle ear squamous cell carcinoma
  • epidermoid carcinoma of the middle ear
middle ear carcinoma
  • carcinoma of middle ear
wolfram syndrome
  • wolfram syndrome 1
quebec platelet disorder
  • factor v quebec
binswanger's disease
  • dementia multi-infarct
- elite association - COSMIC cancer census association via MalaCards
Search RECK in MalaCards View complete list of genes associated with diseases

Relevant External Links for RECK

Genetic Association Database (GAD)
RECK
Human Genome Epidemiology (HuGE) Navigator
RECK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RECK
genes like me logo Genes that share disorders with RECK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RECK Gene

Publications for RECK Gene

  1. Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. (PMID: 9789069) Takahashi C. … Noda M. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 22 64
  2. Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. (PMID: 17033924) Lei H. … FAPrsti A. (Breast Cancer Res. Treat. 2007) 3 22 46 64
  3. RECK-mediated inhibition of glioma migration and invasion. (PMID: 20127710) Silveira CorrA-a T.C. … Maria-Engler S.S. (J. Cell. Biochem. 2010) 3 22 64
  4. Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs. (PMID: 20154725) Loayza-Puch F. … Noda M. (Oncogene 2010) 3 22 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for RECK Gene

Sources for RECK Gene

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