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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RECK Gene

protein-coding GIFtS: 59
GCID: GC09P036036

reversion-inducing-cysteine-rich protein with kazal motifs

(Previous symbol: ST15)

Explore 104 diseases affiliated with
RECK via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs¹ ²		Membrane-Anchored Glycoprotein (Metastasis And Invasion)²
ST15¹ ² ³ ⁵		Reversion-Inducing Cysteine-Rich Protein With Kazal Motifs²
HRECK¹		Suppression Of Tumorigenicity 15 (Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs)²
Suppressor Of Tumorigenicity 15 Protein² ³		Suppression Of Tumorigenicity 5 (Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs)²

External Ids:	HGNC: 11345¹	Entrez Gene: 8434²	Ensembl: ENSG00000122707⁷	OMIM: 605227⁵	UniProtKB: O95980³

Export aliases for RECK gene to outside databases

Previous GC identifers: GC09P036349 GC09P036206 GC09P036026 GC09P035990

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RECK:

The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose

expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells,

this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme

involved in tumor invasion and metastasis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RECK_HUMAN, O95980

Function: Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct

inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and

metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression

Gene Wiki entry for RECK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RECK gene promoter:
MyoD Tal-1beta E47 C/EBPalpha Max FOXO4 ITF-2 c-Myc ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RECK promoter sequence

Search SABiosciences Chromatin IP Primers for RECK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RECK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13.3

RECK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RECK gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P036036: view genomic region (about GC identifiers)

Start:	36,036,430 bp from pter	End:	36,124,452 bp from pter
Size:	88,023 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RECK_HUMAN, O95980 (See protein sequence)

Recommended Name: Reversion-inducing cysteine-rich protein with Kazal motifs precursor

Size: 971 amino acids; 106457 Da

Subunit: Interacts with MMP-9

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor

Secondary accessions: B2RNS1 Q5W0K6 Q8WX37

Explore the universe of human proteins at neXtProt for RECK: NX_O95980

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95980

RECK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_066934.1

ENSEMBL proteins:

ENSP00000367202

Human Recombinant Protein Products for RECK:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for RECK
	GenScript Custom Purified and Recombinant Proteins Services for RECK
	Novus Biologicals RECK Proteins Novus Biologicals RECK Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RECK

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	IEA	--
GO:0016020	membrane	TAS	9789069
GO:0031225	anchored to membrane	IEA	--

RECK for ontologies About GeneDecksing

RECK Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for RECK
	Cell Signaling Technology (CST) Antibodies for RECK
	Browse OriGene Antibodies OriGene Custom Antibody Services for RECK
	GenScript Custom Superior Antibodies Services for RECK
	Novus Biologicals RECK Antibodies
	Abcam antibodies for RECK
	Uscn Antibodies for RECK
	ThermoFisher Antibody for RECK

Assay Products for RECK:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for RECK
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RECK

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RECK for domains About GeneDecksing

2 InterPro domains/families:

IPR002350 Prot_inh_Kazal

IPR011497 Kazal-type_dom

Graphical View of Domain Structure for InterPro Entry O95980

ProtoNet protein and cluster: O95980

1 Blocks protein family: IPB011497 Protease inhibitor

UniProtKB/Swiss-Prot: RECK_HUMAN, O95980

Similarity: Contains 3 Kazal-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RECK_HUMAN, O95980

Function: Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct

inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and

metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004866	endopeptidase inhibitor activity	IDA	9789069
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	--
GO:0008191	metalloendopeptidase inhibitor activity	TAS	9789069

RECK for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for RECK:

Decreased homologous recombina

Increased gamma-H2AX phosphory

10 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Reck):

cardiovascular system	embryogenesis	growth/size	integument	limbs/digits/tail
liver/biliary system	mortality/aging	nervous system	other	skeleton

RECK for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for RECK: Reck^tm1Ito Reck^tm2.2Noda

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RECK

miRNA Products:		miRTarBase miRNAs that target RECK: hsa-mir-373 (MIRT000606), hsa-mir-15b (MIRT000607), hsa-mir-21 (MIRT000969)

		OriGene 3'-UTR Clone: RECK Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RECK
		8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate RECK (see all 76):
		hsa-miR-520e hsa-miR-607 hsa-miR-15a hsa-miR-219-5p hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: RECK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RECK (see all 7) OriGene shRNA RFP: RECK OriGene siRNA: RECK
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RECK
		Sirion Biotech Custom design and validation of potent shRNA sequences against RECK

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for RECK
			Sirion Biotech Customized adenovirus for overexpression of RECK Sirion Biotech Customized adenovirus for potent knockdown of RECK

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RECK (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RECK OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RECK (NM_021111)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RECK
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RECK

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RECK
		Search LifeMap BioReagents cell lines for RECK
		Sirion Biotech Customized stable knockdown cell line services for RECK Sirion Biotech Customized inducible knockdown cell line services for RECK Sirion Biotech Customized stable overexpressing cell line services for RECK Sirion Biotech Customized inducible overexpressing cell line services for RECK

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RECK

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Angiogenesis

Angiogenesis

1.00

Protein Stability

Protein Stability

1.00

Matrix Metalloproteinases

Inhibition of Matrix Metalloproteinases

0.68

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RECK

Inhibition of Matrix Metalloproteinases

2 Cell Signaling Technology (CST) Pathways for RECK

	Angiogenesis
	Protein Stability

RECK for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RECK

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for RECK (O95980^{2, 3} ENSP00000367202⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERBB2	P04626²^,³, ENSP00000269571⁴	MINT-8085378 MINT-8085327 MINT-8085341 MINT-8085361 I2D: score=1 STRING: ENSP00000269571
MMP9	P14780³, ENSP00000361405⁴	I2D: score=1 STRING: ENSP00000361405
TRIM69	Q86WT6³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001955	blood vessel maturation	IEA	--
GO:0007566	embryo implantation	IEA	--
GO:0010951	negative regulation of endopeptidase activity	IDA	9789069
GO:0030198	extracellular matrix organization	IEA	--

RECK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RECK for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RECK
10/69 Novoseek chemical compound relationships for RECK gene (see all 69) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ristocetin	60.5	4	7706202 (1), 2316510 (1), 7607757 (1), 9209928 (1)
castanospermine	58.5	3	2270434 (1), 2341487 (1)
sialic acid	50	4	9688306 (1), 9863654 (1), 10193487 (1), 1566747 (1)
tunicamycin	48	1	2341487 (1)
fibrinogen	47.2	8	15279665 (1), 2040630 (1), 1748654 (1), 11685040 (1) (see all 7)
adp	33.6	3	7706202 (1), 7607757 (1), 16386680 (1)
gp 130	28.9	5	12513832 (1), 1427893 (1), 12917504 (1), 1475713 (1) (see all 5)
ltc4	28.5	3	8125120 (1)
tyrosine	27.7	19	10518415 (2), 7721957 (1), 7741749 (1), 15869600 (1) (see all 17)
n-acetyllactosamine	27.3	1	11530203 (1)

Search CenterWatch for drugs/clinical trials and news about RECK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RECK gene:

NM_021111.2

Unigene Cluster for RECK:

Reversion-inducing-cysteine-rich protein with kazal motifs

Hs.744121 [show with all ESTs]

Unigene Representative Sequence: BX648668

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377966(uc003zyv.3 uc003zyw.3 uc003zyx.3) ENST00000475774(uc010mle.1)

ENST00000479053(uc003zyu.4)

miRNA Products:		OriGene 3'-UTR Clone: RECK Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RECK
		8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate RECK (see all 76):
		hsa-miR-520e hsa-miR-607 hsa-miR-15a hsa-miR-219-5p hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: RECK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RECK (see all 7) OriGene shRNA RFP: RECK OriGene siRNA: RECK
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RECK
		Sirion Biotech Custom design and validation of potent shRNA sequences against RECK

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RECK (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RECK OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RECK (NM_021111)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RECK
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RECK

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RECK Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RECK
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RECK
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RECK

Additional cDNA sequence:

AF086228.1 AK022897.1 AK292653.1 AK315073.1 BC032240.1 BC050306.1 BC060806.1 BC137093.1

BX648668.1 D50406.1 EF139848.1 JQ756320.1

10 DOTS entries:

DT.97780306 DT.312667 DT.101981793 DT.92421066 DT.313183 DT.101968336 DT.95149308 DT.92421072

DT.40113295 DT.97821993

3 AceView cDNA sequences:

AU128294 AK022897 AU150602

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RECK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTGTTGCAA

About this image

RECK expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RECK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RECK

SOURCE GeneReport for Unigene cluster: Hs.744121

UniProtKB/Swiss-Prot: RECK_HUMAN, O95980

Tissue specificity: Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell

lines and oncogenically transformed cells

SABiosciences Custom PCR Arrays for RECK

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RECK Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RECK
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RECK
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RECK

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RECK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RECK gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Reck^{1 , 5}	reversion-inducing-cysteine-rich protein with kazal more^{1, 5}	87.96(n)¹ 93.7(a)¹		4 (23.05 cM)⁵ 53614¹ NM_016678.2¹ NP_057887.2¹ 43875530⁵
chicken (Gallus gallus)	Aves	RECK¹	reversion-inducing-cysteine-rich protein with kazal more	80.24(n) 86.39(a)		420804 XM_418897.3 XP_418897.3
lizard (Anolis carolinensis)	Reptilia	RECK⁶	--	82(a)	1 ↔ 1	6(55744166-55803853)
zebrafish (Danio rerio)	Actinopterygii	CABZ01087302.1⁶	--	55(a)	1 ↔ 1	24(423782-425533)
fruit fly (Drosophila melanogaster)	Insecta	CG5392³ Reck¹	Reversion-inducing-cysteine-rich protein with kazal more¹	33(a)³ 46.6(n)¹ 36.56(a)¹		71B1³ 39629¹ NM_140476.2¹ NP_648733.2¹

ENSEMBL Gene Tree for RECK (if available)
TreeFam Gene Tree for RECK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs13284876^1,2	C,F,A	--	36034961(+)	`GCTGGC/TCTCAA`	1	--	us2k¹		8		NA WA CSA EA	367
rs184741567^1,2		--	36035262(+)	`AAAAAC/TAGAAC`	1	--	us2k¹		0	--	--	--	--
rs10972703^1,2	C,F,A	--	36035309(+)	`TAACTA/GGAGGC`	1	--	us2k¹		8		NA WA CSA EA	367
rs10972704^1,2	C,A	--	36035315(+)	`GAGGCT/CTTTTA`	1	--	us2k¹		6		WA NA CSA EA	363
rs77257424^1,2	F	--	36035321(+)	`TTTTAG/ATGGGA`	1	--	us2k¹		1		NA	120
rs140220314^1,2		--	36035330(+)	`GATAGA/GCCAAA`	1	--	us2k¹		0	--	--	--	--
rs12341409^1,2	C,F	--	36035438(+)	`agaacC/Tacttc`	1	--	us2k¹		6		NA WA CSA EA	246
rs187968126^1,2		--	36035443(+)	`CACTTC/GTGGTT`	1	--	us2k¹		0	--	--	--	--
rs145903941^1,2		--	36035476(+)	`CACCGC/TGTGCT`	1	--	us2k¹		0	--	--	--	--
rs11333791^1,2	C	--	36035556(+)	`TGTTT-/TAGATA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RECK (36036430 - 36124452 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RECK
1 CNV: 47924

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RECK

DNA2.0 Custom Variant and Variant Library Synthesis for RECK

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RECK for disorders           About GeneDecksing

OMIM gene information: 605227    OMIM disorders: --

20/104 diseases for RECK (see all 104):    About MalaCards

bernard-soulier syndrome wiskott-aldrich syndrome lactose intolerance glanzmann's thrombasthenia

paroxysmal nocturnal hemoglobinuria hemolytic-uremic syndrome autoimmune thrombocytopenic purpura anaplastic large cell lymphoma

thrombasthenia optic atrophy wolfram syndrome cocaine abuse

hemoglobinuria ocular albinism cystic fibrosis squamous cell carcinoma

herpes simplex lupus erythematosus prion disease hypolactasia

2 diseases from the University of Copenhagen DISEASES database for RECK:

Cancer Nasopharyngitis

10/86 Novoseek disease relationships for RECK gene (see all 86) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
albinism ocular	68.5	5	8799153 (1), 16524428 (1), 19604113 (1), 12515581 (1) (see all 5)
glanzmann thrombasthenia	61.8	4	1871709 (1), 11844132 (1), 1284039 (1), 19437332 (1)
platelet disorder	51.7	1	16651876 (1)
bernard-soulier syndrome	48.6	2	11844132 (1), 1284039 (1)
tumors	41.1	136	16762015 (5), 16806661 (5), 15876788 (4), 16103099 (4) (see all 65)
metastasis	39	56	17233834 (4), 16951151 (3), 20143471 (3), 17443689 (3) (see all 30)
paroxysmal hemoglobinuria nocturnal	31.5	1	2145990 (1)
mastocytoma	30.5	1	8973633 (1)
wolfram syndrome	29.7	1	16989814 (1)
cancer	29.5	46	20442303 (6), 12784995 (3), 12810630 (2), 17828469 (2) (see all 28)

Human Genome Epidemiology (HuGE) Navigator: RECK (9 documents)

Export disorders for RECK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RECK gene, integrated from 9 sources (see all 443):
(articles sorted by number of sources associating them with RECK)

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Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. (PubMed id 9789069)^{1, 2, 3, 9} Takahashi C.... Noda M. (1998)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways. (PubMed id 17329256)^{1, 9} Miki T....Takahashi C. (2007)
Significance of methylation status and the expression of RECK mRNA in lung tissue of patients with NSCLC. (PubMed id 20032402)^{1, 9} Pesta M....Holubec L. (2009)
RECK is up-regulated and involved in chondrocyte clon ing in human osteoarthritic cartilage. (PubMed id 20395433)^{1, 9} Kimura T....Okada Y. (2010)
Low expression of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) indicates a shorter survival after resection in patients with adenocarcinoma of the lung. (PubMed id 17714826)^{1, 9} Takemoto N....Moriuchi T. (2007)
RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis. (PubMed id 12738734)^{1, 9} Masui T....Imamura M. (2003)
HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. (PubMed id 16377629)^{1, 9} Hsu M.C.... Hung W.C. (2006)
Epigenetic inactivation of the metastasis suppressor RECK enhances invasion of human colon cancer cells. (PubMed id 17443689)^{1, 9} Cho C.Y....Hung W.C. (2007)
Silencing of the metastasis suppressor RECK by RAS oncogene is mediated by DNA methyltransferase 3b-induced promoter methylation. (PubMed id 16951151)^{1, 9} Chang H.C....Hung W.C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8434	HGNC: 11345	AceView: RECK.1	Ensembl:ENSG00000122707	euGenes: HUgn8434
ECgene: RECK	H-InvDB: RECK

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RECK	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RECK	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RECK gene
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Patent Information for RECK gene:
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reversion-inducing-cysteine-rich protein with kazal motifs

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RECK Gene

reversion-inducing-cysteine-rich protein with kazal motifs

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