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RECK Gene

protein-coding   GIFtS: 63
GCID: GC09P036036

Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs


(Previous symbol: ST15)
  See RECK-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs1 2     Reversion-Inducing Cysteine-Rich Protein With Kazal Motifs2
ST151 2 3 5     Suppression Of Tumorigenicity 15 (Reversion-Inducing-Cysteine-Rich Protein
With Kazal Motifs)2
Suppressor Of Tumorigenicity 15 Protein2 3     Suppression Of Tumorigenicity 5 (Reversion-Inducing-Cysteine-Rich Protein
With Kazal Motifs)2
Membrane-Anchored Glycoprotein (Metastasis And Invasion)2     hRECK3

External Ids:    HGNC: 113451   Entrez Gene: 84342   Ensembl: ENSG000001227077   OMIM: 6052275   UniProtKB: O959803   

Export aliases for RECK gene to outside databases

Previous GC identifers: GC09P036349 GC09P036206 GC09P036026 GC09P035990


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RECK Gene:
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains
whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In
normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix
metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. (provided by RefSeq, Jul 2008)

GeneCards Summary for RECK Gene:
RECK (reversion-inducing-cysteine-rich protein with kazal motifs) is a protein-coding gene. Diseases associated with RECK include middle ear squamous cell carcinoma, and nasopharyngitis. GO annotations related to this gene include metalloendopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot: RECK_HUMAN, O95980
Function: Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct
inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and
metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression

Gene Wiki entry for RECK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RECK gene promoter:
         MyoD   Tal-1beta   E47   C/EBPalpha   Max   FOXO4   ITF-2   c-Myc   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRECK promoter sequence
   Search Chromatin IP Primers for RECK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RECK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

RECK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RECK gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P036036:  view genomic region     (about GC identifiers)

Start:
36,036,430 bp from pter      End:
36,124,452 bp from pter
Size:
88,023 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RECK_HUMAN, O95980 (See protein sequence)
Recommended Name: Reversion-inducing cysteine-rich protein with Kazal motifs precursor  
Size: 971 amino acids; 106457 Da
Subunit: Interacts with MMP-9
Secondary accessions: B2RNS1 Q5W0K6 Q8WX37

Explore the universe of human proteins at neXtProt for RECK: NX_O95980

Explore proteomics data for RECK at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn39, Asn86, Asn200, Asn297, Asn352
  • Modification sites at PhosphoSitePlus

  • See RECK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066934.1  
    ENSEMBL proteins: 
     ENSP00000367202  

    RECK Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RECK
    GenScript Custom Purified and Recombinant Proteins Services for RECK
    Novus Biologicals RECK Proteins
    Novus Biologicals RECK Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RECK

     
    Search eBioscience for Proteins for RECK 

    RECK Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for RECK
    Cell Signaling Technology (CST) Antibodies for RECK 
    OriGene Antibodies for RECK
    OriGene Custom Antibody Services for RECK
    Novus Biologicals RECK Antibodies
    Abcam antibodies for RECK (O95980, Q5W0K6)
    Cloud-Clone Corp. Antibodies for RECK
    ThermoFisher Antibody for RECK
    LSBio Antibodies in human, mouse, rat for RECK

    RECK Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Proteome Profiler Antibody Arrays for RECK
    GenScript Custom Assay Services for RECK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RECK
    Cloud-Clone Corp. CLIAs for RECK
    Search eBioscience for ELISAs for RECK 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002350 Kazal_dom

    Graphical View of Domain Structure for InterPro Entry O95980

    ProtoNet protein and cluster: O95980

    1 Blocks protein domain: IPB011497 Protease inhibitor

    UniProtKB/Swiss-Prot: RECK_HUMAN, O95980
    Similarity: Contains 3 Kazal-like domains


    Find genes that share domains with RECK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RECK_HUMAN, O95980
    Function: Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct
    inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and
    metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity IDA9789069
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0005515protein binding IPI--
    GO:0008191metalloendopeptidase inhibitor activity TAS9789069
    GO:0030414peptidase inhibitor activity ----
         
    Find genes that share ontologies with RECK           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RECK:
     Decreased homologous recombina  Increased gamma-H2AX phosphory 

         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Reck):
     cardiovascular system  embryogenesis  growth/size/body  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  nervous system  other  skeleton 

    Find genes that share phenotypes with RECK           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RECK: Recktm1Ito Recktm2.2Noda

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RECK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RECK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RECK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RECK

    miRNA
    Products:
        
    miRTarBase miRNAs that target RECK:
    hsa-mir-124-3p (MIRT022764), hsa-mir-373-3p (MIRT000606), hsa-mir-15b-5p (MIRT000607), hsa-mir-16-5p (MIRT031373), hsa-mir-335-5p (MIRT018129), hsa-mir-182-5p (MIRT007293), hsa-mir-222-3p (MIRT006728), hsa-mir-21-5p (MIRT000969), hsa-mir-15a-5p (MIRT007090), hsa-mir-103a-3p (MIRT027078)

    Block miRNA regulation of human, mouse, rat RECK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RECK (see all 76):
    hsa-miR-520e hsa-miR-607 hsa-miR-15a hsa-miR-219-5p hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidRECK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RECK
    Predesigned siRNA for gene silencing in human, mouse, rat RECK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RECK

    Clone
    Products:
         
    OriGene clones in human, mouse for RECK (see all 6)
    OriGene ORF clones in mouse, rat for RECK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RECK (NM_021111)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RECK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RECK

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RECK
    Browse ESI BIO Cell Lines and PureStem Progenitors for RECK 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RECK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RECK_HUMAN, O95980: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane TAS9789069
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with RECK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RECK About    
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Inhibition of Matrix Metalloproteinases0.68
    2Protein Stability
    Protein Stability
    3MicroRNAs in cancer
    MicroRNAs in cancer
    4Angiogenesis (CST)
    Angiogenesis


    Find genes that share SuperPaths with RECK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RECK
        Inhibition of Matrix Metalloproteinases

    2 Cell Signaling Technology (CST) Pathways for RECK
        Angiogenesis
    Protein Stability


    1 Kegg Pathway  (Kegg details for RECK):
        MicroRNAs in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RECK
    Interactions:

        GeneGlobe Interaction Network for RECK

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for RECK (O959801, 2, 3 ENSP000003672024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-2823742,EBI-641062 MINT-8085378 MINT-8085327 MINT-8085341 MINT-8085361 I2D: score=1 STRING: ENSP00000269571
    MMP9P147803, ENSP000003614054I2D: score=1 STRING: ENSP00000361405
    TRIM69Q86WT63I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001955blood vessel maturation IEA--
    GO:0007566embryo implantation IEA--
    GO:0010951negative regulation of endopeptidase activity IDA9789069
    GO:0030198extracellular matrix organization IEA--

    Find genes that share ontologies with RECK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RECK

    Selected Novoseek inferred chemical compound relationships for RECK gene (see all 69)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ristocetin 60.5 4 7706202 (1), 2316510 (1), 7607757 (1), 9209928 (1)
    castanospermine 58.5 3 2270434 (1), 2341487 (1)
    sialic acid 50 4 9688306 (1), 9863654 (1), 10193487 (1), 1566747 (1)
    tunicamycin 48 1 2341487 (1)
    fibrinogen 47.2 8 15279665 (1), 2040630 (1), 1748654 (1), 11685040 (1) (see all 7)
    adp 33.6 3 7706202 (1), 7607757 (1), 16386680 (1)
    gp 130 28.9 5 12513832 (1), 1427893 (1), 12917504 (1), 1475713 (1) (see all 5)
    ltc4 28.5 3 8125120 (1)
    tyrosine 27.7 19 10518415 (2), 7721957 (1), 7741749 (1), 15869600 (1) (see all 17)
    n-acetyllactosamine 27.3 1 11530203 (1)



    Find genes that share compounds with RECK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RECK gene: 
    NM_021111.2  

    Unigene Cluster for RECK:

    Reversion-inducing-cysteine-rich protein with kazal motifs
    Hs.388918  [show with all ESTs]
    Unigene Representative Sequence: BX648668
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377966(uc003zyv.3 uc003zyw.3 uc003zyx.3) ENST00000475774(uc010mle.1)
    ENST00000479053(uc003zyu.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RECK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RECK (see all 76):
    hsa-miR-520e hsa-miR-607 hsa-miR-15a hsa-miR-219-5p hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidRECK 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RECK
    Predesigned siRNA for gene silencing in human, mouse, rat RECK
    Clone
    Products:
         
    OriGene clones in human, mouse for RECK (see all 6)
    OriGene ORF clones in mouse, rat for RECK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RECK (NM_021111)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RECK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RECK
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RECK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RECK
      QuantiTect SYBR Green Assays in human, mouse, rat RECK
      QuantiFast Probe-based Assays in human, mouse, rat RECK

    Additional mRNA sequence: 

    AF086228.1 AK022897.1 AK292653.1 AK315073.1 BC032240.1 BC050306.1 BC060806.1 BC137093.1 
    BX648668.1 D50406.1 EF139848.1 JQ756320.1 

    11 DOTS entries:

    DT.97780306  DT.312667  DT.101981793  DT.92421066  DT.313183  DT.101968336  DT.95149308  DT.40278363 
    DT.92421072  DT.40113295  DT.97821993 

    3 AceView cDNA sequences:

    AU128294 AK022897 AU150602 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RECK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGTTGCAA
    RECK Expression
    About this image


    RECK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Fibroblasts
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
    RECK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RECK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.388918

    UniProtKB/Swiss-Prot: RECK_HUMAN, O95980
    Tissue specificity: Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell
    lines and oncogenically transformed cells

        Custom PCR Arrays for RECK
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RECK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RECK
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    QuantiFast Probe-based Assays in human, mouse, rat RECK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RECK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RECK gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Reck1 , 5 reversion-inducing-cysteine-rich protein with kazal more1, 5 87.96(n)1
    93.7(a)1
      4 (23.05 cM)5
    536141  NM_016678.21  NP_057887.21 
     438755305 
    chicken
    (Gallus gallus)
    Aves RECK1 reversion-inducing-cysteine-rich protein with kazal more 80.36(n)
    86.7(a)
      420804  XM_418897.4  XP_418897.4 
    lizard
    (Anolis carolinensis)
    Reptilia RECK6
    reversion-inducing-cysteine-rich protein with kaza...
    79(a)
    1 ↔ 1
    6(55739974-55809477)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia reck1 reversion-inducing-cysteine-rich protein with kazal more 72.66(n)
    76.97(a)
      100486433  XM_002938937.2  XP_002938983.2 
    zebrafish
    (Danio rerio)
    Actinopterygii RECK6
    reversion-inducing-cysteine-rich protein with kaza...
    55(a)
    1 ↔ 1
    24(423782-425533) ENSDARG00000090039
    fruit fly
    (Drosophila melanogaster)
    Insecta CG53923
    Reck1
    Reversion-inducing-cysteine-rich protein with kazal more1 33(a)3
    47.08(n)1
    37.17(a)1
      71B13
    396291  NM_001274924.11  NP_001261853.11 


    ENSEMBL Gene Tree for RECK (if available)
    TreeFam Gene Tree for RECK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RECK (see all 1771)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs132848761,2
    C,F,A--36034961(+) gctggC/Tctcaa 1 -- us2k18Minor allele frequency- T:0.42NA WA CSA EA 367
    rs1847415671,2
    C--36035262(+) AAAAAC/TAGAAC 1 -- us2k10--------
    rs109727031,2
    C,F,A--36035309(+) taactA/Ggaggc 1 -- us2k18Minor allele frequency- G:0.40NA WA CSA EA 367
    rs109727041,2
    C,A--36035315(+) gaggcT/Ctttta 1 -- us2k16Minor allele frequency- C:0.40WA NA CSA EA 363
    rs772574241,2
    C,F--36035321(+) TTTTAG/ATGGGA 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1402203141,2
    --36035330(+) GATAGA/GCCAAA 1 -- us2k10--------
    rs123414091,2
    C,F--36035438(+) agaacC/Tacttc 1 -- us2k16Minor allele frequency- T:0.12NA WA CSA EA 246
    rs1879681261,2
    --36035443(+) CACTTC/GTGGTT 1 -- us2k10--------
    rs1459039411,2
    --36035476(+) CACCGC/TGTGCT 1 -- us2k10--------
    rs113337911,2
    C--36035556(+) TGTTT-/TAGATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RECK (36036430 - 36124452 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RECK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34080CNV Loss18971310
    nsv831546CNV Loss17160897
    nsv831547CNV Loss17160897
    nsv893049CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RECK
    DNA2.0 Custom Variant and Variant Library Synthesis for RECK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605227    OMIM disorders: --

    8 diseases for RECK:    
    About MalaCards
    middle ear squamous cell carcinoma    nasopharyngitis    lactose intolerance    binswanger's disease
    autoimmune thrombocytopenic purpura    congenital nystagmus    bernard-soulier syndrome    malaria

    2 diseases from the University of Copenhagen DISEASES database for RECK:
    Cancer     Nasopharyngitis

    Find genes that share disorders with RECK           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RECK gene (see all 86)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    albinism ocular 68.5 5 8799153 (1), 16524428 (1), 19604113 (1), 12515581 (1) (see all 5)
    glanzmann thrombasthenia 61.8 4 1871709 (1), 11844132 (1), 1284039 (1), 19437332 (1)
    platelet disorder 51.7 1 16651876 (1)
    bernard-soulier syndrome 48.6 2 11844132 (1), 1284039 (1)
    tumors 41.1 136 16762015 (5), 16806661 (5), 15876788 (4), 16103099 (4) (see all 65)
    metastasis 39 56 17233834 (4), 16951151 (3), 20143471 (3), 17443689 (3) (see all 30)
    paroxysmal hemoglobinuria nocturnal 31.5 1 2145990 (1)
    mastocytoma 30.5 1 8973633 (1)
    wolfram syndrome 29.7 1 16989814 (1)
    cancer 29.5 46 20442303 (6), 12784995 (3), 12810630 (2), 17828469 (2) (see all 28)

    Genetic Association Database (GAD): RECK
    Human Genome Epidemiology (HuGE) Navigator: RECK (9 documents)

    Export disorders for RECK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RECK gene, integrated from 10 sources (see all 457):
    (articles sorted by number of sources associating them with RECK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. (PubMed id 9789069)1, 2, 3, 9 Takahashi C.... Noda M. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. (PubMed id 17033924)1, 4, 9 Lei H....FAPrsti A. (Breast Cancer Res. Treat. 2007)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways. (PubMed id 17329256)1, 9 Miki T....Takahashi C. (J. Biol. Chem. 2007)
    7. Significance of methylation status and the expression of RECK mRNA in lung tissue of patients with NSCLC. (PubMed id 20032402)1, 9 Pesta M....Holubec L. (Anticancer Res. 2009)
    8. RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage. (PubMed id 20395433)1, 9 Kimura T....Okada Y. (Am. J. Pathol. 2010)
    9. Low expression of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) indicates a shorter survival after resection in patients with adenocarcinoma of the lung. (PubMed id 17714826)1, 9 Takemoto N....Moriuchi T. (Lung Cancer 2007)
    10. RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis. (PubMed id 12738734)1, 9 Masui T....Imamura M. (Clin. Cancer Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8434 HGNC: 11345 AceView: RECK.1 Ensembl:ENSG00000122707 euGenes: HUgn8434
    ECgene: RECK Kegg: 8434 H-InvDB: RECK

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RECK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RECK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RECK gene:
    Search GeneIP for patents involving RECK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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