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REC8 Gene

protein-coding   GIFtS: 54
GCID: GC14P024641

REC8 Meiotic Recombination Protein

(Previous names: REC8-like 1 (yeast), REC8 homolog (yeast))
(Previous symbol: REC8L1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
REC8 Meiotic Recombination Protein1 2     Human Homolog Of Rad21, S. Pombe2
REC8L11 2 3 5     kleisin-alpha2
Cohesin Rec8p2 3     Meiotic Recombination And Sister Chromatid Cohesion Phosphoprotein Of The
Rad21p Family2
REC8 Homolog (Yeast)1     Meiotic Recombination Protein REC8 Homolog2
REC8-Like 1 (Yeast)1     Meiotic Recombination Protein REC8-Like 12
HR21spB2     REC8 Homolog2
Rec8p2     REC8-Like 12
Cohesion Rec8p2     Recombination And Sister Chromatid Cohesion Protein Homolog2

External Ids:    HGNC: 168791   Entrez Gene: 99852   Ensembl: ENSG000001009187   OMIM: 6081935   UniProtKB: O950723   

Export aliases for REC8 gene to outside databases

Previous GC identifers: GC14P022013 GC14P018428 GC14P023712 GC14P004756


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for REC8 Gene:
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners.
The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In
the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister
chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants,
encoding the same protein, have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for REC8 Gene:
REC8 (REC8 meiotic recombination protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: REC8_HUMAN, O95072
Function: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic
cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in
meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in
meiosis II (By similarity)

Gene Wiki entry for REC8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the REC8 gene promoter:
         STAT1   GATA-3   AML1a   STAT1beta   GATA-1   GATA-2   STAT1alpha   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidREC8 promoter sequence
   Search Chromatin IP Primers for REC8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat REC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2-q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2-q12

REC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
REC8 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024641:  view genomic region     (about GC identifiers)

Start:
24,641,062 bp from pter      End:
24,649,463 bp from pter
Size:
8,402 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: REC8_HUMAN, O95072 (See protein sequence)
Recommended Name: Meiotic recombination protein REC8 homolog  
Size: 547 amino acids; 62614 Da
Subunit: Interacts (phosphorylated and unphosphorylated form) with SMC3. Interacts with SYCP3. Interacts
(phosphorylated and unphosphorylated form) with SMC1B. Does not interact with SMC1A. Interacts with RAD51 (By
similarity)
Secondary accessions: A8K576 D3DS62 Q658V5 Q6IA92 Q8WUV8 Q9BTF2 Q9NVQ9
Alternative splicing: 2 isoforms:  O95072-1   O95072-2   

Explore the universe of human proteins at neXtProt for REC8: NX_O95072

Explore proteomics data for REC8 at MOPED

Post-translational modifications: 

  • Phosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See REC8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001041670.1  NP_005123.2  

    ENSEMBL proteins: 
     ENSP00000308699   ENSP00000453763   ENSP00000453242   ENSP00000453506   ENSP00000452701  
    Reactome Protein details: O95072

    REC8 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for REC8

     
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    antibodies-online proteins for REC8 (5 products) 

     
    antibodies-online peptides for REC8

    REC8 Antibody Products:

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    antibodies-online antibodies for REC8 (52 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR023093 Rad21/Rec8_C
     IPR006909 Rad21/Rec8_C_eu
     IPR006910 Rad21_Rec8_N

    Graphical View of Domain Structure for InterPro Entry O95072

    ProtoNet protein and cluster: O95072

    UniProtKB/Swiss-Prot: REC8_HUMAN, O95072
    Similarity: Belongs to the rad21 family


    Find genes that share domains with REC8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REC8_HUMAN, O95072
    Function: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic
    cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in
    meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in
    meiosis II (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with REC8           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for REC8:
     Increased G2M DNA content  Increased cell number in G1, a 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rec8):
     endocrine/exocrine gland  growth/size/body  mortality/aging  reproductive system 

    Find genes that share phenotypes with REC8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rec8tm1Mjm for REC8

       genOway: Develop your customized and physiologically relevant rodent model for REC8

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    REC8_HUMAN, O95072: Nucleus (By similarity). Chromosome (By similarity). Note=In meiotic chromosomes, localized
    along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and
    metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No
    longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II (By
    similarity). Localised to centromeres and spindle poles in endopolyploid tumor cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    mitochondrion3
    peroxisome2
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228nuclear chromosome ----
    GO:0000778condensed nuclear chromosome kinetochore IEA--
    GO:0000780condensed nuclear chromosome, centromeric region ----
    GO:0000794condensed nuclear chromosome ----
    GO:0000795synaptonemal complex ----

    Find genes that share ontologies with REC8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for REC8 About    
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Meiotic Synapsis0.66
    Chromosome Maintenance0.62
    2Cell Cycle, Mitotic
    Cell Cycle0.90
    3Meiosis (REACTOME)
    Meiosis0.74
    4Oocyte meiosis
    Oocyte meiosis0.35
    5Meiosis (EMD)
    Meiosis


    Find genes that share SuperPaths with REC8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for REC8
        Meiotic synapsis


    1 Kegg Pathway  (Kegg details for REC8):
        Oocyte meiosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for REC8
    Interactions:

        Search GeneGlobe Interaction Network for REC8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for REC8 (O950723 ENSP000003086994) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC3Q9UQE73, ENSP000003547204I2D: score=2 STRING: ENSP00000354720
    SMC1AQ146833, ENSP000003234214I2D: score=1 STRING: ENSP00000323421
    SYCP3Q8IZU33, ENSP000002667434I2D: score=1 STRING: ENSP00000266743
    SMC1BQ8NDV33, ENSP000003500364I2D: score=1 STRING: ENSP00000350036
    CHPT1Q8WUD63I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IEA--
    GO:0001556oocyte maturation IEA--
    GO:0007062sister chromatid cohesion TAS10207075
    GO:0007126meiotic nuclear division TAS10207075
    GO:0007129synapsis ----

    Find genes that share ontologies with REC8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for REC8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for REC8 gene (2 alternative transcripts): 
    NM_001048205.1  NM_005132.2  

    Unigene Cluster for REC8:

    REC8 homolog (yeast)
    Hs.419259  [show with all ESTs]
    Unigene Representative Sequence: AK291191
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311457(uc001wmr.3) ENST00000557806 ENST00000559919(uc001wms.3)
    ENST00000557979 ENST00000560032 ENST00000560501 ENST00000558782 ENST00000558697
    ENST00000560823 ENST00000559797 ENST00000558191 ENST00000559939 ENST00000558381

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      QuantiTect SYBR Green Assays in human, mouse, rat REC8
      QuantiFast Probe-based Assays in human, mouse, rat REC8

    Additional mRNA sequence: 

    AF006264.1 AK001435.1 AK291191.1 BC004159.2 BC010887.1 BC019326.1 CR457263.1 

    24 DOTS entries:

    DT.100766403  DT.218437  DT.86846030  DT.120755377  DT.95276416  DT.91994166  DT.100882958  DT.100770363 
    DT.100882969  DT.100761370  DT.95227146  DT.40106663  DT.120755442  DT.92436507  DT.112651  DT.75155957 
    DT.95290752  DT.100711408  DT.120755347  DT.120755395  DT.120755438  DT.95253622  DT.95276418  DT.40309448 

    Selected AceView cDNA sequences (see all 216):

    BE208628 AI681192 BU073018 BE796050 BX395041 BE672597 CR596261 AI292039 
    AI871013 AI275745 AW007750 AA903350 CB850852 AI887614 Z39039 BU738577 
    AI202674 BU071004 CR597987 AI253211 AA912087 BQ949022 BQ267638 Z45121 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for REC8 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^
    SP1:                                      -                                               -                                                                     
    SP2:                    -                 -                                               -                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                      -                                                                     
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b · 16c ^ 17 ^ 18
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for REC8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    REC8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATGCCTT
    REC8 Expression
    About this image


    REC8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             XX Germ Cells Ovigerous Cord
             Oviduct
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Gonad
             Primary Spermatocyte Seminiferous Tubules
     
     Neural Tube (Nervous System)
             Telencephalon
    REC8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    REC8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.419259

    UniProtKB/Swiss-Prot: REC8_HUMAN, O95072
    Tissue specificity: Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa (at protein
    level)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for REC8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for REC8 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rec81 , 5 REC8 homolog (yeast)1, 5 79.2(n)1
    75.93(a)1
      14 (28.19 cM)5
    567391  NM_020002.31  NP_064386.21 
     556180375 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    59(a)
    44(a)
    many → 1
    many → 1
    AAWZ02037623(8303-15323)
    GL343400.1(3561-17846)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rec81 REC8 meiotic recombination protein 54.31(n)
    50.11(a)
      780060  NM_001079137.1  NP_001072605.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rec8a6
    rec8b6
    REC8 homolog b (yeast)
    34(a)
    32(a)
    many → 1
    many → 1
    2(5854588-5874907) ENSDARG00000078329
    24(12592132-12636552) ENSDARG00000069260


    ENSEMBL Gene Tree for REC8 (if available)
    TreeFam Gene Tree for REC8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for REC8 (see all 363)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1419110541,2
    C--5636576(+) ATACAA/GAAAAA 2 -- us2k10--------
    rs2015978891,2
    C--5636748(+) AAAAAA/CAAAAA 2 -- us2k10--------
    rs742426991,2
    --5636763(+) ACTCTC/TAAATT 2 -- us2k10--------
    rs1395622751,2
    --5636857(+) GAGAAA/GGACAT 2 -- us2k10--------
    rs1841151871,2
    --5636910(+) GACAAA/GGGTTA 2 -- us2k10--------
    rs1510619701,2
    C--5636920(+) ATTAT-/TACAACTG 2 -- us2k10--------
    rs1883126411,2
    --5636939(+) TTAAAC/TTTACA 2 -- us2k10--------
    rs172567131,2
    C,F,H--5636989(+) TTGTGC/TTGCAT 2 -- us2k120Minor allele frequency- T:0.14NA NS EA CSA 2366
    rs1807712871,2
    --5637029(+) GAGAAC/TACTGA 2 -- us2k10--------
    rs1154217381,2
    C,F--5637095(+) GAAGTG/CACCCC 2 -- us2k11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for REC8 (24641062 - 24649463 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for REC8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522667CNV Loss19592680
    nsv901498CNV Loss21882294
    nsv7249OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608193    OMIM disorders: --


    Find genes that share disorders with REC8           About GenesLikeMe

    Genetic Association Database (GAD): REC8
    Human Genome Epidemiology (HuGE) Navigator: REC8 (6 documents)

    Export disorders for REC8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for REC8 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with REC8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans. (PubMed id 10207075)1, 2, 3, 9 Parisi S....Kohli J. (Mol. Cell. Biol. 1999)
    2. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    3. Analysis of the meiotic recombination gene REC8 for sequence variations in a population with severe male factor infertility. (PubMed id 18570052)1, 4 Griffin J....Carrell D.T. (Syst Biol Reprod Med 2008)
    4. Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis. (PubMed id 15935783)1, 3 Xu H....McKay M.J. (Dev. Cell 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis. (PubMed id 12759374)1, 3 Lee J....Yamashita M. (J. Cell. Sci. 2003)
    8. The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells. (PubMed id 19463812)1 Erenpreisa J....Scherthan H. (Exp. Cell Res. 2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9985 HGNC: 16879 AceView: REC8L1 Ensembl:ENSG00000100918 euGenes: HUgn9985
    ECgene: REC8 Kegg: 9985 H-InvDB: REC8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for REC8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for REC8 gene:
    Search GeneIP for patents involving REC8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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