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Aliases for REC114 Gene

Aliases for REC114 Gene

  • REC114 Meiotic Recombination Protein 2 3 5
  • C15orf60 3 4
  • Meiotic Recombination Protein REC114-Like 3
  • Meiotic Recombination Protein REC114 3
  • Chromosome 15 Open Reading Frame 60 2
  • CT147 3

External Ids for REC114 Gene

Previous HGNC Symbols for REC114 Gene

  • C15orf60

Summaries for REC114 Gene

GeneCards Summary for REC114 Gene

REC114 (REC114 Meiotic Recombination Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for REC114 Gene

  • May play a role in meiotic DNA double-strand break formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REC114 Gene

Genomics for REC114 Gene

Regulatory Elements for REC114 Gene

Enhancers for REC114 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F073318 0.9 FANTOM5 ENCODE 16.8 -57.3 -57304 0.4 MXI1 RFX1 POLR2A GLIS1 MYNN MAX BMI1 RFX5 REC114 NEO1 HCN4 PIR60762 PIR39750
GH15F073374 1 VISTA 0.8 +0.2 183 4.3 ZNF263 ZNF687 RFX1 PKNOX1 ZBED1 ZNF133 ZNF76 REST ZIC2 GATA3 ENSG00000261384 ADPGK NEO1 REC114 GC15P073451
GH15F073386 1.1 Ensembl ENCODE 0.4 +11.8 11772 2.0 USF1 PKNOX1 JUN MAX ZEB1 RFX5 GATA3 ZFHX2 CTBP1 RCOR1 REC114 GC15P073451
GH15F073389 0.6 ENCODE 0.4 +13.6 13589 1.1 ELF3 TEAD4 MNT ZNF644 SMARCA4 POLR2A PRDM10 MAFK NFE2L2 HCN4 REC114 GC15P073451
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around REC114 on UCSC Golden Path with GeneCards custom track

Genomic Location for REC114 Gene

Chromosome:
15
Start:
73,376,209 bp from pter
End:
73,560,014 bp from pter
Size:
183,806 bases
Orientation:
Plus strand

Genomic View for REC114 Gene

Genes around REC114 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REC114 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REC114 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REC114 Gene

Proteins for REC114 Gene

  • Protein details for REC114 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4M0-RE114_HUMAN
    Recommended name:
    Meiotic recombination protein REC114
    Protein Accession:
    Q7Z4M0

    Protein attributes for REC114 Gene

    Size:
    266 amino acids
    Molecular mass:
    29155 Da
    Quaternary structure:
    • Interacts with MEI4.
    SequenceCaution:
    • Sequence=AAH55412.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for REC114 Gene

Post-translational modifications for REC114 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REC114 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for REC114 Gene

Domains & Families for REC114 Gene

Protein Domains for REC114 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z4M0

UniProtKB/Swiss-Prot:

RE114_HUMAN :
  • Belongs to the REC114 family.
Family:
  • Belongs to the REC114 family.
genes like me logo Genes that share domains with REC114: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for REC114 Gene

Function for REC114 Gene

Molecular function for REC114 Gene

UniProtKB/Swiss-Prot Function:
May play a role in meiotic DNA double-strand break formation.
genes like me logo Genes that share phenotypes with REC114: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for REC114 Gene

Localization for REC114 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REC114 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for REC114 Gene

Pathways & Interactions for REC114 Gene

SuperPathways for REC114 Gene

No Data Available

Interacting Proteins for REC114 Gene

Selected Interacting proteins: Q7Z4M0-RE114_HUMAN for REC114 Gene via IID

Gene Ontology (GO) - Biological Process for REC114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination IEA --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with REC114: view

No data available for Pathways by source and SIGNOR curated interactions for REC114 Gene

Transcripts for REC114 Gene

mRNA/cDNA for REC114 Gene

(2) REFSEQ mRNAs :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for REC114 Gene

No ASD Table

Relevant External Links for REC114 Gene

GeneLoc Exon Structure for
REC114
ECgene alternative splicing isoforms for
REC114

Expression for REC114 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for REC114 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for REC114 Gene

This gene is overexpressed in Plasma (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for REC114 Gene



Protein tissue co-expression partners for REC114 Gene

NURSA nuclear receptor signaling pathways regulating expression of REC114 Gene:

REC114
genes like me logo Genes that share expression patterns with REC114: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for REC114 Gene

Orthologs for REC114 Gene

This gene was present in the common ancestor of chordates.

Orthologs for REC114 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf60 34
  • 99.62 (n)
C15orf60 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C10H15orf60 34
  • 81.12 (n)
dog
(Canis familiaris)
Mammalia C30H15orf60 34
  • 79.45 (n)
C15orf60 35
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1311874 34
  • 77.86 (n)
mouse
(Mus musculus)
Mammalia 2410076I21Rik 34 35
  • 76.45 (n)
Rec114 16
oppossum
(Monodelphis domestica)
Mammalia C15orf60 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C15orf60 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10H15ORF60 34
  • 65.17 (n)
C15orf60 35
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C15orf60 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734605 34
  • 55.09 (n)
zebrafish
(Danio rerio)
Actinopterygii C18H15orf60 (2 of 2) 35
  • 41 (a)
OneToMany
C18H15orf60 (1 of 2) 35
  • 38 (a)
OneToMany
Species where no ortholog for REC114 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for REC114 Gene

ENSEMBL:
Gene Tree for REC114 (if available)
TreeFam:
Gene Tree for REC114 (if available)

Paralogs for REC114 Gene

No data available for Paralogs for REC114 Gene

Variants for REC114 Gene

Sequence variations from dbSNP and Humsavar for REC114 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10152690 -- 73,514,916(+) ACTGC(C/G)TTTAA intron-variant
rs10162605 -- 73,482,702(+) ctact(A/G)taggt intron-variant
rs10162732 -- 73,528,643(+) aaaaa(A/T)tcaga intron-variant
rs10163172 -- 73,516,261(+) AATTA(C/T)AAGTG intron-variant
rs1043555 -- 73,560,267(-) TTTTT(C/T)TTTTG intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for REC114 Gene

Variant ID Type Subtype PubMed ID
nsv525433 CNV loss 19592680
nsv1139632 CNV duplication 24896259
nsv1121512 CNV deletion 24896259
nsv1051734 CNV loss 25217958
esv3636889 CNV loss 21293372
esv3636888 CNV loss 21293372
esv2749872 CNV deletion 23290073
esv2673071 CNV deletion 23128226
esv2662664 CNV deletion 23128226

Variation tolerance for REC114 Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REC114 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
REC114

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REC114 Gene

Disorders for REC114 Gene

Relevant External Links for REC114

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REC114

No disorders were found for REC114 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REC114 Gene

Publications for REC114 Gene

  1. Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. (PMID: 20551173) Kumar R. … de Massy B. (Genes Dev. 2010) 2 3 64
  2. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3 64
  3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for REC114 Gene

Sources for REC114 Gene

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