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Aliases for REC114 Gene

Aliases for REC114 Gene

  • REC114 Meiotic Recombination Protein 2 3 5
  • C15orf60 3 4
  • Meiotic Recombination Protein REC114-Like 3
  • Chromosome 15 Open Reading Frame 60 2
  • CT147 3

External Ids for REC114 Gene

Previous HGNC Symbols for REC114 Gene

  • C15orf60

Summaries for REC114 Gene

GeneCards Summary for REC114 Gene

REC114 (REC114 Meiotic Recombination Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for REC114 Gene

  • May play a role in meiotic DNA double-strand break formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REC114 Gene

Genomics for REC114 Gene

Genomic Location for REC114 Gene

Chromosome:
15
Start:
73,376,209 bp from pter
End:
73,560,014 bp from pter
Size:
183,806 bases
Orientation:
Plus strand

Genomic View for REC114 Gene

Genes around REC114 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REC114 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REC114 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REC114 Gene

No data available for Regulatory Elements for REC114 Gene

Proteins for REC114 Gene

  • Protein details for REC114 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4M0-RE114_HUMAN
    Recommended name:
    Meiotic recombination protein REC114
    Protein Accession:
    Q7Z4M0

    Protein attributes for REC114 Gene

    Size:
    266 amino acids
    Molecular mass:
    29155 Da
    Quaternary structure:
    • Interacts with MEI4.
    SequenceCaution:
    • Sequence=AAH55412.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for REC114 Gene

Proteomics data for REC114 Gene at MOPED

Post-translational modifications for REC114 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REC114 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for REC114 Gene

Domains & Families for REC114 Gene

Protein Domains for REC114 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z4M0

UniProtKB/Swiss-Prot:

RE114_HUMAN :
  • Belongs to the REC114 family.
Family:
  • Belongs to the REC114 family.
genes like me logo Genes that share domains with REC114: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for REC114 Gene

Function for REC114 Gene

Molecular function for REC114 Gene

UniProtKB/Swiss-Prot Function:
May play a role in meiotic DNA double-strand break formation.
genes like me logo Genes that share phenotypes with REC114: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for REC114 Gene

Localization for REC114 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for REC114 Gene

Pathways & Interactions for REC114 Gene

SuperPathways for REC114 Gene

No Data Available

Interacting Proteins for REC114 Gene

Gene Ontology (GO) - Biological Process for REC114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination IEA --
genes like me logo Genes that share ontologies with REC114: view

No data available for Pathways by source and SIGNOR curated interactions for REC114 Gene

Drugs & Compounds for REC114 Gene

No Compound Related Data Available

Transcripts for REC114 Gene

mRNA/cDNA for REC114 Gene

(3) REFSEQ mRNAs :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for REC114 Gene

No ASD Table

Relevant External Links for REC114 Gene

GeneLoc Exon Structure for
REC114
ECgene alternative splicing isoforms for
REC114

Expression for REC114 Gene

mRNA expression in normal human tissues for REC114 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for REC114 Gene

This gene is overexpressed in Plasma (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for REC114 Gene



genes like me logo Genes that share expression patterns with REC114: view

Protein tissue co-expression partners for REC114 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for REC114 Gene

Orthologs for REC114 Gene

This gene was present in the common ancestor of chordates.

Orthologs for REC114 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C10H15orf60 35
  • 81.12 (n)
  • 76.95 (a)
dog
(Canis familiaris)
Mammalia C30H15orf60 35
  • 79.45 (n)
  • 70.68 (a)
C15orf60 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2410076I21Rik 35
  • 76.45 (n)
  • 68.73 (a)
Rec114 16
2410076I21Rik 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf60 35
  • 99.62 (n)
  • 99.62 (a)
C15orf60 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1311874 35
  • 77.86 (n)
  • 71.43 (a)
oppossum
(Monodelphis domestica)
Mammalia C15orf60 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C15orf60 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10H15ORF60 35
  • 65.17 (n)
  • 56.76 (a)
C15orf60 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C15orf60 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734605 35
  • 55.09 (n)
  • 43.66 (a)
zebrafish
(Danio rerio)
Actinopterygii C18H15orf60 (1 of 2) 36
  • 38 (a)
OneToMany
C18H15orf60 (2 of 2) 36
  • 41 (a)
OneToMany
Species with no ortholog for REC114:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for REC114 Gene

ENSEMBL:
Gene Tree for REC114 (if available)
TreeFam:
Gene Tree for REC114 (if available)

Paralogs for REC114 Gene

No data available for Paralogs for REC114 Gene

Variants for REC114 Gene

Sequence variations from dbSNP and Humsavar for REC114 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs12102004 - 73,551,046(+) TGCAG(A/G)TGCCT reference, missense
rs1280334 -- 73,471,988(-) tttgc(C/T)gtctt intron-variant
rs1481088 -- 73,549,920(+) AAATT(A/G)TGAAC intron-variant
rs1481090 -- 73,527,728(-) GTCTA(G/T)TTTTA intron-variant
rs1481091 -- 73,527,574(-) TAGAC(A/G)GTACA intron-variant

Variation tolerance for REC114 Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for REC114 Gene

HapMap Linkage Disequilibrium report
REC114

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for REC114 Gene

Disorders for REC114 Gene

Relevant External Links for REC114

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
REC114

No disorders were found for REC114 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REC114 Gene

Publications for REC114 Gene

  1. Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. (PMID: 20551173) Kumar R. … de Massy B. (Genes Dev. 2010) 2 3 67
  2. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for REC114 Gene

Sources for REC114 Gene

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