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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RDX Gene

protein-coding   GIFtS: 66
GCID: GC11M110045

radixin

(Previous names: deafness, autosomal recessive 24 )
(Previous symbol: DFNB24)
 Explore 29 diseases affiliated with
RDX via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RDX    

Aliases
for RDX gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Radixin1
DFNB241 2 5
Deafness, Autosomal Recessive 241

External Ids:    HGNC: 99441   Entrez Gene: 59622   Ensembl: ENSG000001377107   OMIM: 1794105   UniProtKB: P352413   

Export aliases for RDX gene to outside databases

Previous GC identifers: GC11M112371 GC11M111571 GC11M110134 GC11M109637 GC11M109605 GC11M106024


Summaries
for RDX gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RDX:
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar
in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to
11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to
lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: RADI_HUMAN, P35241
Function: Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane

Gene Wiki entry for RDX (Radixin)


Genomic Views
for RDX gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RDX gene promoter:
         ISGF-3   Sox5   POU3F2 (N-Oct-5b)   C/EBPalpha   IRF-2   POU2F1   POU2F1b   POU2F1a   Sox9   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RDX promoter sequence
   Search SABiosciences Chromatin IP Primers for RDX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RDX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q23

RDX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RDX gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M110045:  view genomic region     (about GC identifiers)

Start:
 110,045,605 bp from pter      End:
 110,167,447 bp from pter
Size:
 121,843 bases      Orientation:
 minus strand

Proteins
for RDX gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RADI_HUMAN, P35241 (See protein sequence)
Recommended Name: Radixin  
Size: 583 amino acids; 68564 Da
Subunit: Binds SLC9A3R1. Interacts with NHERF1, NHERF2, LAYN, MME/NEP and ICAM2 (By similarity)
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage
furrow. Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the
interphase and mitotic phase, respectively
Secondary accessions: A7YIK0 A7YIK3 Q86Y61
Alternative splicing: 3 isoforms:  P35241-1   P35241-2   P35241-3   

Explore the universe of human proteins at neXtProt for RDX: NX_P35241

Post-translational modifications:

  • Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the
    • N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding
    (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P35241

    • RDX Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001247421.1  NP_001247422.1  NP_001247423.1  NP_001247424.1  NP_001247425.1  NP_002897.1  

    ENSEMBL proteins: 
     ENSP00000437301   ENSP00000432112   ENSP00000384136   ENSP00000433580   ENSP00000436277  
     ENSP00000342830   ENSP00000432829   ENSP00000434788   ENSP00000431560   ENSP00000437140  
     ENSP00000434881   ENSP00000432572   ENSP00000435930   ENSP00000445826  
    Reactome Protein details: P35241
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: RDX
    OriGene Protein Over-expression Lysate: RDX
    OriGene Custom Protein Services for RDX 
    GenScript Custom Purified and Recombinant Proteins Services for RDX
    Novus Biologicals RDX Protein
    Novus Biologicals RDX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RDX

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005730nucleolus ----
    GO:0005737cytoplasm IEA--
    GO:0005794Golgi apparatus ----
    GO:0005856cytoskeleton IEA--


    RDX for ontologies           About GeneDecksing



    RDX Antibody Products: 
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    Cell Signaling Technology (CST) Antibodies for RDX  (radixin)
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    GenScript Superior Antibodies for RDX
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    Abcam antibodies for RDX 
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    ThermoFisher Antibody for RDX

    Assay Products for RDX: 
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    Uscn ELISAs and CLIAs for RDX

    Protein Domains /
    Families
    for RDX gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RDX for domains           About GeneDecksing

    5/13 InterPro domains/families (see all 13):
     IPR019748 FERM_central
     IPR019750 Band_41_fam
     IPR000798 Ez/rad/moesin
     IPR008954 Moesin
     IPR019747 FERM_CS

    Graphical View of Domain Structure for InterPro Entry P35241

    ProtoNet protein and cluster: P35241

    2 Blocks protein families:
    IPB000299 Band 4.1 domain
    IPB000798 ERM family signature


    UniProtKB/Swiss-Prot: RADI_HUMAN, P35241
    Domain: The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its
    N-terminal and C-terminal domains inhibits its ablilty to bind LAYN. In the presence of acidic phospholipids, the
    interdomain interaction is inhibited and this enhances binding to LAYN (By similarity)
    Similarity: Contains 1 FERM domain


    Function
    for RDX gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RADI_HUMAN, P35241
    Function: Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane
    Enzyme regulation: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation
    (inactive form) which is incapable of actin or membrane-binding (By similarity)

         Genatlas biochemistry entry for RDX:
    radixin,actin capping protein,ezrin/moesin/radixin-like (ERM) family member,responding and participating in
    reorganization of membrane-cytoplasmic interactions,highly expressed in the undercoat of the adherens
    junction,involved in regulation of linkage of the cytoskeleton to the plasma membrane,deleted in
    lymphocytes,monocytes,neutrophils and platelet,not sensitive to capain

    miRNA
    Products:            		miRTarBase miRNAs that target RDX:
    hsa-mir-31 (MIRT004979)

    OriGene 3'-UTR Clone: RDX
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RDX
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate RDX (see all 36):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-let-7d hsa-miR-346 hsa-miR-500a hsa-let-7g hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: RDX 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RDX (see all 7)
    OriGene shRNA RFP: RDX
    OriGene siRNA: RDX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RDX

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RDX

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RDX (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RDX (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): RDX (NM_181697)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RDX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RDX 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RDX
    Search LifeMap BioReagents cell lines for RDX

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RDX

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI--
    GO:0008092cytoskeletal protein binding ----


    RDX for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for RDX:
     Decreased viability after Chla  Increased S DNA content 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rdx):
     behavior/neurological  hearing/vestibular/ear  homeostasis/metabolism  liver/biliary system  nervous system 

    RDX for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RDX gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		L1CAM interactions0.39
    		Developmental Biology0.69
    		Recycling pathway of L10.15
    2Regulation of Actin Cytoskeleton
    		Regulation of Actin Cytoskeleton1.00
    		Regulation of actin cytoskeleton0.58
    3G-protein signaling Regulation of RAC1 activity
    		G-protein signaling Rac2 regulation pathway0.16
    		G-protein signaling_Rac2 regulation pathway0.16
    4Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    5RhoA signaling pathway
    		RhoA signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RDX
        G-protein signaling Rac2 regulation pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RDX
        RhoA Pathway
    Rho Family GTPases
    Transendothelial Migration of Leukocytes

    1 Cell Signaling Technology (CST) Pathway for RDX
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for RDX
        G-protein signaling Rac2 regulation pathway

    2 BioSystems Pathways for RDX 
        Regulation of Actin Cytoskeleton
    RhoA signaling pathway

    4        Reactome Pathways for RDX
        L1CAM interactions
    Recycling pathway of L1
    Developmental Biology
    Axon guidance


    1         Kegg Pathway  (Kegg details for RDX):
        Regulation of actin cytoskeleton


    RDX for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RDX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for RDX (P352412, 3 ENSP000003428304) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB2P051072, 3, ENSP000003032424MINT-4652127 MINT-4652107 I2D: score=2 STRING: ENSP00000303242
    ARHGDIAP525652, 3, ENSP000002693214MINT-18849 MINT-18848 I2D: score=4 STRING: ENSP00000269321
    MCF2P109112, 3, ENSP000003970554MINT-17859 MINT-17858 I2D: score=1 STRING: ENSP00000397055
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030033microvillus assembly IEA--
    GO:0045176apical protein localization IEA--
    GO:0051693actin filament capping IEA--


    RDX for ontologies           About GeneDecksing



    Drugs & Compounds
    for RDX gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RDX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RDX

    1 DrugBank Compound for RDX    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    D-Myo-Inositol-1,4,5-Triphosphate-- --target--17139284 17016423 10592235

    10/12 Novoseek chemical compound relationships for RDX gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 44.6 7 11387207 (1), 11502006 (1), 9918767 (1), 16394012 (1) (see all 7)
    tyrosine 38.3 13 11587846 (1), 15277531 (1), 17024180 (1), 1382070 (1) (see all 12)
    gdp 20.9 3 9681826 (2), 9287351 (1)
    phosphatidylinositol 18.5 2 16054017 (1), 17827228 (1)
    hyaluronic acid 16.8 1 15326184 (1)
    phosphotyrosine 14.9 2 1382070 (1), 12535520 (1)
    calcium 3.06 1 18290763 (1)
    gtp 0 2 9681826 (2)
    lipid 0 1 17982024 (1), 17538024 (1)
    zinc 0 1 14550572 (1)

    Search CenterWatch for drugs/clinical trials and news about RDX / RADI 

    Transcripts
    for RDX gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RDX gene (6 alternative transcripts): 
    NM_001260492.1  NM_001260493.1  NM_001260494.1  NM_001260495.1  NM_001260496.1  NM_002906.3  

    Unigene Cluster for RDX:

    Radixin
    Hs.263671  [show with all ESTs]
    Unigene Representative Sequence: NM_002906
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530749(uc009yxx.1) ENST00000528498 ENST00000405097(uc009yxy.3)
    ENST00000528900(uc009yxz.3) ENST00000530301(uc009yya.3) ENST00000527537(uc001pks.3)
    ENST00000532461(uc001pkt.3) ENST00000343115(uc001pku.3 uc010rwe.2)
    ENST00000533961 ENST00000530131 ENST00000530085 ENST00000529774 ENST00000534683
    ENST00000532118 ENST00000528556 ENST00000533991 ENST00000533678 ENST00000544551


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RDX
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate RDX (see all 36):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-let-7d hsa-miR-346 hsa-miR-500a hsa-let-7g hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: RDX 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RDX (see all 7)
    OriGene shRNA RFP: RDX
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RDX
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): RDX (NM_181697)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RDX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RDX 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RDX

    Additional cDNA sequence: 

    AF086024.1 AK295075.1 AK312903.1 AK316061.1 BC002626.2 BC020751.1 BC029467.1 BC047109.1 
    BX648536.1 DQ916738.1 DQ916739.1 DQ916740.1 DQ916742.1 L02320.1 

    17 DOTS entries:

    DT.97803338  DT.101974122  DT.215749  DT.101981317  DT.100825101  DT.100825093  DT.95158114  DT.97788679 
    DT.100825095  DT.101955213  DT.215863  DT.95132655  DT.99962028  DT.100825096  DT.100825097  DT.91721350 
    DT.92457353 

    24/308 AceView cDNA sequences (see all 308):

    BQ010341 AI365124 BM699208 BM669870 CK430198 BU078898 AI962841 BU742336 
    BU679292 T16589 AI573251 BU630298 BQ632112 H88675 AA479781 BF592841 
    BX501284 CB148160 BU734583 CB143914 BE350211 AW264233 T32559 CK724983 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RDX (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^
    SP1:                                      -     -                                                                                                               
    SP2:                                                                                                                                                            
    SP3:                                      -                                                                                                                     
    SP4:                                                                                                                          -     -                           
    SP5:        -     -     -     -           -     -                                                                                                               

    ExUns: 18 ^ 19
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for RDX

    Expression
    for RDX gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RDX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RDX expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungLung BudLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RDX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RDX

    SOURCE GeneReport for Unigene cluster: Hs.263671
        SABiosciences Expression via Pathway-Focused PCR Arrays including RDX: 
              Cytoskeleton Regulators in human mouse rat
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for RDX gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RDX gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RDX1 radixin 86.45(n)
    97.77(a)    		   395511  NM_204751.1  NP_990082.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RDX6
    		 --
    		 95(a)
    		 1 ↔ 1
    		 3(186424392-186439477)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.203302 Xenopus laevis transcribed sequence with moderate similarity more 81.88(n)    BQ726565.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii msnb1 moesin b 69.74(n)
    77.04(a)    		   553434  XM_695235.5  XP_700327.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Moe3 establishment and/or maintenance of
    epithelial more    		 59(a)
    (best of 2)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea erm-13 membrane protein 53(a)
    (best of 2)    		   I(5284602-5291512)   --


    ENSEMBL Gene Tree for RDX (if available)
    TreeFam Gene Tree for RDX (if available) 

    Paralogs
    for RDX gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RDX gene
    MSN2  FRMD4A2  NF22  FRMD4B2  EZR2  C1orf1062  
    18/25 SIMAP similar genes for RDX using alignment to 13 protein entries:     RADI_HUMAN (see all proteins) (see all similar genes):
    DKFZp434I0812    EZR-ROS1    VIL2    MSN    EZR    NF2
    ZNF843    ZNF573    BNC2    KIAA1651    FLJ20555    PTPN3
    FRMD4B    FARP2    PTPN4    FRMD5    EPB41L1    EPB41L3

    RDX for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RDX
    PGOHUM00000242130 PGOHUM00000241219 PGOHUM00000241682


    Genomic Variants
    for RDX gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1924 NCBI SNPs in RDX are shown (see all 1924)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1877909831,2
    		--110045125(+) TCCCTC/TACCGT 1 -- ds50010--------
    rs108910711,2
    		C,F,A,H,--110045141(+) CCTACA/GGAGCC 1 -- ds500140Minor allele frequency- G:0.35NA NS EA WA CSA 3704
    rs1417381521,2
    		--110045191(+) GACGAA/TGTACA 1 -- ds50010--------
    rs1924594651,2
    		--110045509(+) TGCTAC/GGAATG 1 -- ds50010--------
    rs1414143351,2
    		--110045691(+) ACACA-/CCTTCA 1 -- ut310--------
    rs79419031,2
    		C,F,A,H,--110045731(+) GACAAC/TGATGT 1 -- ut3138Minor allele frequency- N:0.00EA NA NS WA CSA 3422
    rs1131792221,2
    		C,--110045787(+) GGCTTGTG/-GTGAT 1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs1473775971,2
    		C,--110045883(+) AGCAA-/CAGTGG 1 -- ut310--------
    rs1845030431,2
    		--110046025(+) TAGGGC/TGTTTT 1 -- int10--------
    rs1894379151,2
    		--110046153(+) ACCATA/GAGATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RDX (110045605 - 110167447 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RDX: --
    Human Gene Mutation Database (HGMD): RDX

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for RDX gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RDX for disorders           About GeneDecksing

    OMIM gene information: 179410   
    OMIM disorders: 611022  
    UniProtKB/Swiss-Prot: RADI_HUMAN, P35241
  • Defects in RDX are the cause of deafness autosomal recessive type 24 (DFNB24) [MIM:611022]. DFNB24 is a form
    • of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear,
    the nerve pathways to the brain, or the area of the brain that receives sound information

    20/29 diseases for RDX (see all 29):    About MalaCards
    deafness, autosomal recessive, 24    von hippel-lindau disease    cancer progression/metastasis    temporal lobe epilepsy
    hearing loss    primary biliary cirrhosis    neuroma    systemic lupus erythematosus
    lupus erythematosus    rheumatoid arthritis    prostate cancer, progression of    west syndrome
    neurofibromatosis    prostate cancer, progression and metastasis of    glaucoma    prostate cancer
    down syndrome    meningioma    cholestasis    arthritis

    2 diseases from the University of Copenhagen DISEASES database for RDX:
    Neurofibromatosis     Meningioma

    10/14 Novoseek disease relationships for RDX gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 2 87.6 9 9553042 (1), 15467741 (1), 8012352 (1), 11438984 (1) (see all 9)
    meningioma 59.9 4 18190852 (1), 8586465 (1), 17640904 (1), 11368764 (1)
    schwannoma 55.6 4 9403715 (3), 11368764 (1)
    tumors 33.4 26 11092524 (2), 9553042 (1), 15467741 (1), 16054017 (1) (see all 23)
    neuroma acoustic 32.6 1 8586465 (1)
    metastasis 12.3 5 19152423 (1), 19875476 (1), 20036004 (1), 17874463 (1)
    carcinoma squamous cell 0 1 15655179 (1)
    breast carcinoma 0 2 18190852 (1), 17640904 (1)
    dysplasia 0 1 17910583 (1)
    cancer lung 0 2 18190852 (1), 17640904 (1)

    Human Genome Epidemiology (HuGE) Navigator: RDX (2 documents)

    Export disorders for RDX gene to outside databases

    Publications
    for RDX gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RDX gene, integrated from 9 sources (see all 305):
    (articles sorted by number of sources associating them with RDX)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus. (PubMed id 17226784)1, 2, 3, 9 Khan S.Y....Riazuddin S. (2007)
    2. Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes. (PubMed id 8486357)1, 2, 3, 9 Wilgenbus K.K.... Furthmayr H. (1993)
    3. NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins. (PubMed id 9430655)1, 2, 9 Murthy A.... Ramesh V. (1998)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Disturbed colocalization of multidrug resistance protein 2 and radixin in human cholestatic liver diseases. (PubMed id 17725603)1, 9 Kojima H....Fukui H. (2008)
    6. Ezrin and radixin both regulate the apical membrane localization of ABCC2 (MRP2) in human intestinal epithelial Caco-2 cells. (PubMed id 17825285)1, 9 Yang Q....Sugiyama Y. (2007)
    7. Differential expression and distribution of ezrin, radixin and moesin in human natural killer cells. (PubMed id 12385025)1, 9 Ramoni C....Fais S. (2002)
    8. Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. (PubMed id 14568249)1, 9 Kojima H....Keppler D. (2003)
    9. Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl. (PubMed id 9681826)1, 9 Takahashi K....Takai Y. (1998)
    10. A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites. (PubMed id 1429901)1, 9 Sato N....Tsukita S. (1992)

    External Searches for RDX gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RDX gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5962 HGNC: 9944 AceView: RDX Ensembl:ENSG00000137710 euGenes: HUgn5962
    ECgene: RDX Kegg: 5962 H-InvDB: RDX

    Other Databases showing RDX gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RDX gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RDX Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RDX gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RDX gene:
    Search GeneIP for patents involving RDX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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