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Aliases for RDX Gene

Aliases for RDX Gene

  • Radixin 2 3
  • DFNB24 3 6
  • Deafness, Autosomal Recessive 24 2

External Ids for RDX Gene

Previous HGNC Symbols for RDX Gene

  • DFNB24

Previous GeneCards Identifiers for RDX Gene

  • GC11M112371
  • GC11M111571
  • GC11M109637
  • GC11M109605
  • GC11M106024
  • GC11M110045

Summaries for RDX Gene

Entrez Gene Summary for RDX Gene

  • Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for RDX Gene

RDX (Radixin) is a Protein Coding gene. Diseases associated with RDX include deafness, autosomal recessive 24 and dfnb24 nonsyndromic hearing loss and deafness. Among its related pathways are Proteoglycans in cancer and Regulation of actin cytoskeleton. GO annotations related to this gene include actin binding. An important paralog of this gene is C1orf106.

UniProtKB/Swiss-Prot for RDX Gene

  • Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane

Gene Wiki entry for RDX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RDX Gene

Genomics for RDX Gene

Regulatory Elements for RDX Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RDX Gene

Start:
110,174,880 bp from pter
End:
110,296,722 bp from pter
Size:
121,843 bases
Orientation:
Minus strand

Genomic View for RDX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RDX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RDX Gene

Proteins for RDX Gene

  • Protein details for RDX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35241-RADI_HUMAN
    Recommended name:
    Radixin
    Protein Accession:
    P35241
    Secondary Accessions:
    • A7YIJ8
    • A7YIK0
    • A7YIK3
    • B7Z9U6
    • F5H1A7
    • Q86Y61

    Protein attributes for RDX Gene

    Size:
    583 amino acids
    Molecular mass:
    68564 Da
    Quaternary structure:
    • Binds SLC9A3R1. Interacts with NHERF1, NHERF2, LAYN, MME/NEP and ICAM2 (By similarity).

    Alternative splice isoforms for RDX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RDX Gene

Proteomics data for RDX Gene at MOPED

Post-translational modifications for RDX Gene

  • Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity).
  • Ubiquitination at Lys35, Lys79, Lys83, Lys162, Lys209, Lys237, Lys296, and Lys526
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RDX (Radixin)

No data available for DME Specific Peptides for RDX Gene

Domains for RDX Gene

Suggested Antigen Peptide Sequences for RDX Gene

Graphical View of Domain Structure for InterPro Entry

P35241

UniProtKB/Swiss-Prot:

RADI_HUMAN :
  • P35241
Domain:
  • The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ability to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN (By similarity).
  • Contains 1 FERM domain.
genes like me logo Genes that share domains with RDX: view

No data available for Gene Families for RDX Gene

Function for RDX Gene

Molecular function for RDX Gene

GENATLAS Biochemistry:
radixin,actin capping protein,ezrin/moesin/radixin-like (ERM) family member,responding and participating in reorganization of membrane-cytoplasmic interactions,highly expressed in the undercoat of the adherens junction,involved in regulation of linkage of the cytoskeleton to the plasma membrane,deleted in lymphocytes,monocytes,neutrophils and platelet,not sensitive to capain
UniProtKB/Swiss-Prot EnzymeRegulation:
A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.
UniProtKB/Swiss-Prot Function:
Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane

Gene Ontology (GO) - Molecular Function for RDX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 10806479
GO:0008092 cytoskeletal protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RDX: view
genes like me logo Genes that share phenotypes with RDX: view

miRNA for RDX Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RDX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RDX Gene

Localization for RDX Gene

Subcellular locations from UniProtKB/Swiss-Prot for RDX Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RDX Gene COMPARTMENTS Subcellular localization image for RDX gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
golgi apparatus 3
nucleus 3

Gene Ontology (GO) - Cellular Components for RDX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with RDX: view

Pathways for RDX Gene

genes like me logo Genes that share pathways with RDX: view

Pathways by source for RDX Gene

1 Cell Signaling Technology pathway for RDX Gene
2 BioSystems pathways for RDX Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for RDX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization --
GO:0010628 positive regulation of gene expression IGI 23264465
GO:0030033 microvillus assembly IEA --
GO:0045176 apical protein localization IEA --
GO:0051693 actin filament capping IEA --
genes like me logo Genes that share ontologies with RDX: view

Compounds for RDX Gene

(1) Drugbank Compounds for RDX Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
D-Myo-Inositol-1,4,5-Triphosphate
target

(12) Novoseek inferred chemical compound relationships for RDX Gene

Compound -log(P) Hits PubMed IDs
threonine 44.6 7
tyrosine 38.3 12
gdp 20.9 3
phosphatidylinositol 18.5 2
hyaluronic acid 16.8 1
genes like me logo Genes that share compounds with RDX: view

Transcripts for RDX Gene

Unigene Clusters for RDX Gene

Radixin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RDX

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RDX Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^
SP1: - -
SP2:
SP3: -
SP4: - -
SP5: - - - - - -
SP6: - - -
SP7: - -
SP8: -
SP9:
SP10:

ExUns: 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for RDX Gene

GeneLoc Exon Structure for
RDX
ECgene alternative splicing isoforms for
RDX

Expression for RDX Gene

mRNA expression in normal human tissues for RDX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RDX Gene

This gene is overexpressed in Adrenal Gland (6.1).

Protein differential expression in normal tissues for RDX Gene

This gene is overexpressed in Testis (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RDX Gene

SOURCE GeneReport for Unigene cluster for RDX Gene Hs.263671

genes like me logo Genes that share expressions with RDX: view

Expression partners for RDX Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RDX Gene

Orthologs for RDX Gene

This gene was present in the common ancestor of animals.

Orthologs for RDX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RDX 35
  • 94.57 (n)
  • 99.14 (a)
RDX 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RDX 35
  • 93.93 (n)
  • 99.17 (a)
RDX 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rdx 35
  • 90.17 (n)
  • 98.46 (a)
Rdx 16
Rdx 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RDX 35
  • 99.72 (n)
  • 100 (a)
RDX 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rdx 35
  • 90.22 (n)
  • 97.6 (a)
oppossum
(Monodelphis domestica)
Mammalia RDX 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RDX 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves RDX 35
  • 86.45 (n)
  • 97.77 (a)
RDX 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RDX 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5935 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.20330 35
zebrafish
(Danio rerio)
Actinopterygii msna 35
  • 70.59 (n)
  • 82.01 (a)
nf2b 36
  • 42 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2827 35
fruit fly
(Drosophila melanogaster)
Insecta Mer 37
  • 41 (a)
Moe 37
  • 59 (a)
Moe 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea erm-1 37
  • 53 (a)
nfm-1 37
  • 30 (a)
erm-1 36
  • 56 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6897 36
  • 57 (a)
OneToMany
Species with no ortholog for RDX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RDX Gene

ENSEMBL:
Gene Tree for RDX (if available)
TreeFam:
Gene Tree for RDX (if available)

Paralogs for RDX Gene

Paralogs for RDX Gene

Pseudogenes.org Pseudogenes for RDX Gene

genes like me logo Genes that share paralogs with RDX: view

Variants for RDX Gene

Sequence variations from dbSNP and Humsavar for RDX Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs625747 -- 110,182,531(-) CTCCA(C/T)CTCTC intron-variant
rs745754 -- 110,194,199(-) AAATA(C/T)AGCCT intron-variant
rs745755 -- 110,194,196(-) TACAG(C/T)CTGGA intron-variant
rs747943 -- 110,193,641(+) TTCCA(A/G)AGAAG intron-variant
rs898845 -- 110,182,165(+) ACTGA(A/G)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RDX Gene

Variant ID Type Subtype PubMed ID
nsv484 CNV Loss 18451855

Relevant External Links for RDX Gene

HapMap Linkage Disequilibrium report
RDX
Human Gene Mutation Database (HGMD)
RDX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RDX Gene

Disorders for RDX Gene

(1) OMIM Diseases for RDX Gene (179410)

UniProtKB/Swiss-Prot

RADI_HUMAN
  • Deafness, autosomal recessive, 24 (DFNB24) [MIM:611022]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:17226784}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RDX Gene

(14) Novoseek inferred disease relationships for RDX Gene

Disease -log(P) Hits PubMed IDs
neurofibromatosis type 2 87.6 9
meningioma 59.9 4
schwannoma 55.6 4
tumors 33.4 24
neuroma acoustic 32.6 1

Relevant External Links for RDX

Genetic Association Database (GAD)
RDX
Human Genome Epidemiology (HuGE) Navigator
RDX
genes like me logo Genes that share disorders with RDX: view

No data available for Genatlas for RDX Gene

Publications for RDX Gene

  1. Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes. (PMID: 8486357) Wilgenbus K.K. … Furthmayr H. (Genomics 1993) 2 3 4 23
  2. Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus. (PMID: 17226784) Khan S.Y. … Riazuddin S. (Hum. Mutat. 2007) 2 3 4 23
  3. Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study. (PMID: 19754948) Wolf C. … Weisschuh N. (BMC Med. Genet. 2009) 3 23 48
  4. Disturbed colocalization of multidrug resistance protein 2 and radixin in human cholestatic liver diseases. (PMID: 17725603) Kojima H. … Fukui H. (J. Gastroenterol. Hepatol. 2008) 3 23
  5. Ezrin and radixin both regulate the apical membrane localization of ABCC2 (MRP2) in human intestinal epithelial Caco-2 cells. (PMID: 17825285) Yang Q. … Sugiyama Y. (Exp. Cell Res. 2007) 3 23

Products for RDX Gene

  • Addgene plasmids for RDX

Sources for RDX Gene

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