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RDX Gene

protein-coding GIFtS: 68

GC11M109605

radixin
(Previous names: deafness, autosomal recessive 24 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: DFNB24)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DFNB24 ^², ⁵
radixin ^²

Descriptions
deafness, autosomal recessive 24 ^¹

External Ids
HGNC: 9944¹
Entrez Gene: 5962²
UniProtKB: P35241³
Ensembl: ENSG00000137710⁷

Search outside databases for aliases for RDX gene

Previous GC identifers: GC11M112371 GC11M111571 GC11M110134 GC11M109637

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RDX:

Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It

is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by

fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2)

was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p

by Southern and PCR analyses. [provided by RefSeq]

UniProtKB/Swiss-Prot: RADI_HUMAN, P35241

Function: Probably plays a crucial role in the binding of the barbed end of actin filaments to the

plasma membrane

Gene Wiki entry for RDX (Radixin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RDX gene

Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q23

RDX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M109605: (about GC identifiers)

Start:	109,571,496 bp from pter
End:	109,672,647 bp from pter
Size:	101,152 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RADI_HUMAN, P35241 (See protein sequence)

Recommended Name: Radixin

Size: 583 amino acids; 68564 Da

Subunit: Binds SLC9A3R1. Interacts with NHERF1, NHERF2, LAYN, MME/NEP and ICAM2 (By similarity)

Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm,

cytoskeleton. Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and

the cleavage furrow in the interphase and mitotic phase, respectively

Secondary accessions: Q86Y61

Post-translational modifications:

Phosphorylated by tyrosine-protein kinases (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002897.1

ENSEMBL proteins:

ENSP00000384136 ENSP00000342830

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Ezrin / Radixin / Moesin, Radixin)
	Human Recombinant Proteins from Abnova (RDX)

OriGene Purified Recombinant Human Protein: RDX

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0019898	extrinsic to membrane	IEA	--

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Antibodies for RDX:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RDX
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for RDX (Radixin)
	Antibodies from Abcam (Ezrin / Radixin / Moesin, Radixin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RDX)
	Novus Biologicals Antibodies for RDX

Assays for RDX:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P35241

ProtoNet protein and cluster: P35241

2 Blocks protein families:

IPB000299 Band 4.1 domain

IPB000798 ERM family signature

UniProtKB/Swiss-Prot: RADI_HUMAN, P35241

Domain: The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain

interaction between its N-terminal and C-terminal domains inhibits its ablilty to bind LAYN. In

the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances

binding to LAYN (By similarity)

Similarity: Contains 1 FERM domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RDX)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RDX)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002906

Applied Biosystems Silencer® siRNAs for RDX

Sigma-Aldrich siRNA for RDX

Sigma-Aldrich shRNA Panels and shRNA for RDX

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RDX
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002906
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002906
untagged cDNA clones in CMV expression vector (see all 2): NM_002906

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002906

UniProtKB/Swiss-Prot: RADI_HUMAN, P35241

Function: Probably plays a crucial role in the binding of the barbed end of actin filaments to the

plasma membrane

Genatlas biochemistry entry for RDX:

radixin,actin capping protein,ezrin/moesin/radixin-like (ERM) family member,responding and

participating in reorganization of membrane-cytoplasmic interactions,highly expressed in the

undercoat of the adherens junction,involved in regulation of linkage of the cytoskeleton to the

plasma membrane,deleted in lymphocytes,monocytes,neutrophils and platelet,not sensitive to capain

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rdx):

behavior/neurological

hearing/vestibular/ear

homeostasis/metabolism

liver/biliary system

nervous system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for RDX (Your Favorite Gene powered by Ingenuity)

Leukocyte Extravasation Signaling
Actin Cytoskeleton Signaling

GeneDecks RDX for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for RDX

5/28 Interacting proteins for RDX (ENSP00000342830³ P35241²) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARHGDIA	P52565²	STRING (score=.937) MINT-18849 MINT-18848
MCF2	P10911²	STRING (score=.956) MINT-17859 MINT-17858
ITGB2	P05107²	MINT-4652127 MINT-4652107
SLC9A1	ENSP00000263980³	STRING (score=.991)
SLC9A3R1	ENSP00000262613³	STRING (score=.973)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007605	sensory perception of sound	IEA	--
GO:0030033	microvillus assembly	IEA	--
GO:0045176	apical protein localization	IEA	--
GO:0051016	barbed-end actin filament capping	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RDX
9 Novoseek chemical compound relationships for RDX gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	43.26	7	11387207 (1), 11502006 (1), 9918767 (1), 16394012 (1) (see all 7)
tyrosine	36.53	11	11587846 (1), 15277531 (1), 17024180 (1), 1382070 (1) (see all 10)
gdp	23.33	3	9681826 (2), 9287351 (1)
phosphatidylinositol	21.01	2	16054017 (1), 17827228 (1)
phosphotyrosine	16.98	2	1382070 (1), 12535520 (1)
calcium	3.44	1	18290763 (1)
lipid	0.00	1	17982024 (1), 17538024 (1)
zinc	0.00	1	14550572 (1)
gtp	0.00	2	9681826 (2)

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2 PharmGKB drug compound relationships for RDX gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RDX)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RDX)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002906

Sigma-Aldrich siRNA for RDX

Sigma-Aldrich shRNA Panels and shRNA for RDX

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002906

REFSEQ mRNAs for RDX gene:

NM_002906.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002906

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002906
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002906
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002906

Additional cDNA sequence:

AF086024.1 AK295075.1 AK312903.1 AK316061.1 BC002626.2 BC020751.1 BC029467.1 BC047109.1

BC127248.1 BX648536.1 DQ916738.1 DQ916739.1 DQ916740.1 DQ916741.1 DQ916742.1 L02320.1

16 DOTS entries:

DT.97803338 DT.101974122 DT.215749 DT.101981317 DT.404826 DT.100825101 DT.100825093 DT.95158114

DT.97788679 DT.100825095 DT.101955213 DT.215863 DT.40197717 DT.91721350 DT.95132655 DT.99962028

24/308 AceView cDNA sequences (see all 308 ):

AI242238 BM973545 BU078898 BC002626 BQ447711 AI351747 T16402 BC020751

AI609818 BE138912 AI373255 BQ632112 AW183680 BX501284 AI693697 BQ010341

AI365124 AA430011 T16589 CK300704 BE350211 BU079182 AW136407 AA281544

highest scoring ESTs for RDX:

AA113430 AU077254 AU119270 AU134152 AW025631 BC002626 BC047109 BE391924 BG528339 BG538628

Unigene Cluster for RDX:

Radixin

Hs.263671 [show with all ESTs]

Unigene Representative Sequence: NM_002906

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RDX (see all 10 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	·	15c	^	16	^	17	^
SP1:													-		-
SP2:
SP3:													-
SP4:																																									-		-
SP5:			-		-		-		-				-		-

ExUns:	18	^	19
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for RDX

2 Ensembl transcripts including schematic representations:

ENST00000405097 ENST00000343115

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RDX expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RDX

¹ / ² / ³

11 probe-sets matching RDX gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34886_at²^{, 3}	U95-A	1	1.00	1.00	0.71	0.97	L02320	0.80	1.00	0.91	1
56730_at²	U95-B	1	1.00	1.00	0.79	0.81	--	--	--	--	--
34887_at²^{, 3}	U95-A	1	0.94	1.00	0.83	1.24	N92548	0.60	1.00	0.82	1
244739_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
212398_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI057093	0.60	1.00	0.82	1
212397_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL137751	0.40	1.00	0.76	1
204969_s_at²^{, 3}	U133-A	3	1.00	0.86	--	--	NM_002906	0.60	1.00	0.82	1
244739_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212398_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212397_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204969_s_at²	U133Plus2	3	1.00	0.86	--	--	--	--	--	--	--

GeneDecks RDX for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCAGATAAGA

SOURCE GeneReport for Unigene cluster: Hs.263671
Expression variation in blood from EXPOLDB for RDX

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RDX gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RDX¹	--	radixin	93.88(n) 99.31(a)	479446 XM_536581.2 XP_536581.2
chimpanzee (Pan troglodytes)	RDX¹	--	radixin	99.71(n) 100(a)	466776 XM_522176.2 XP_522176.2
cow (Bos taurus)	RDX¹	--	radixin	94.57(n) 99.14(a)	517111 NM_001075749.1 NP_001069217.1
rat (Rattus norvegicus)	Rdx¹	--	radixin	90.22(n) 97.6(a)	315655 NM_001005889.2 NP_001005889.2
mouse (Mus musculus)	Rdx^{1, 5}	9⁵	radixin^{1, 5}	89.94(n)¹ 97.94(a)¹	19684¹ NM_009041.2¹ NP_033067.1¹ AA516625⁵ AI449408⁵ (see all 27)

About this table Species with no ortholog for RDX

ENSEMBL Gene Tree for RDX

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RDX gene

MSN² EZR²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/344 NCBI SNPs in RDX are shown (see all 344 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 89)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1676522^1,2	A,C,F,H	109673884(+)	`TGTGAC/TTTGCG`	1	--	ng3¹		11		EU EA WA NA	1106
	rs34471100^1,2	C,F	109609291(+)	`CTCATC/TGTGTT`	1	D/N	mis¹		6		NA EU EA WA NS	532
--	rs1792789^1,2	A,C	109674553(+)	`AACCCC/TTAAGA`	1	--	ng3¹		0	--	--	--	--
	rs12575547^1,2	H	109640725(+)	`ATTTAG/CTTTAA`	1	V/L	mis¹		4		EU EA WA	416
--	rs45606636^1,2	F	109606884(+)	`AGAAAA/-GGTCC`	1	--	ut3¹		1		NS	38
--	rs45563634^1,2	F	109673371(+)	`GCATTC/TGATCT`	1	--	ng3¹		1		NS	26
--	rs7107158^1,2	C	109672500(+)	`GCTGGC/GCCGCG`	1	--	ut5¹ ese³		0	--	--	--	--
--	rs1676512^1,2	A,C,F,H,O	109666585(-)	`ACATTC/TGGACA`	1	--	int¹		5		MN EU EA WA	602
	rs1676535^1,2	A,C,F,H,O	109671341(-)	`AAAAGC/TCTAAG`	1	--	int¹		11		EU EA WA NA	970
	rs2306085^1,2	A,C,F,H,O	109631407(-)	`TAAGAT/CTGGTC`	1	--	int¹		8		NA EU EA WA NS	592

About this table

HapMap Linkage Disequilibrium images for RDX (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 179410 disorders: 611022

UniProtKB/Swiss-Prot: RADI_HUMAN, P35241

Defects in RDX are the cause of non-syndromic sensorineural deafness autosomal recessive

type 24 (DFNB24) [MIM:611022]. DFNB24 is a form of sensorineural hearing loss. Sensorineural

deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the

brain, or the area of the brain that receives sound information

10/14 Novoseek disease relationships for RDX gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neurofibromatosis type 2	88.48	9	9553042 (1), 15467741 (1), 8012352 (1), 11438984 (1) (see all 9)
meningioma	61.75	4	18190852 (1), 8586465 (1), 17640904 (1), 11368764 (1)
schwannoma	57.54	4	9403715 (3), 11368764 (1)
neuroma acoustic	34.95	1	8586465 (1)
tumors	33.03	25	11092524 (2), 9553042 (1), 15467741 (1), 16054017 (1) (see all 22)
metastasis	9.17	3	19152423 (1), 17874463 (1)
breast carcinoma	2.04	2	18190852 (1), 17640904 (1)
dysplasia	0.00	1	17910583 (1)
cancer lung	0.00	2	18190852 (1), 17640904 (1)
cancer	0.00	4	11092524 (1), 15908786 (1), 19152423 (1)

About this table

1 PharmGKB disease relationship for RDX gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

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Human Gene Mutation Database: RDX

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/250 PubMed articles for RDX gene (see all 250 ):

Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus. (PubMed id 17226784)^{1, 2, 3, 4} Khan S.Y....Riazuddin S. (2007)
Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes. (PubMed id 8486357)^{1, 2, 3, 4} Wilgenbus K.K.... Furthmayr H. (1993)
NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins. (PubMed id 9430655)^{1, 3, 4} Murthy A....Ramesh V. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Disturbed colocalization of multidrug resistance protein 2 and radixin in human cholestatic liver diseases. (PubMed id 17725603)^{1, 3} Kojima H....Fukui H. (2008)
Ezrin and radixin both regulate the apical membrane localization of ABCC2 (MRP2) in human intestinal epithelial Caco-2 cells. (PubMed id 17825285)^{1, 3} Yang Q....Sugiyama Y. (2007)
Differential expression and distribution of ezrin, radixin and moesin in human natural killer cells. (PubMed id 12385025)^{1, 3} Ramoni C....Fais S. (2002)
Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. (PubMed id 14568249)^{1, 3} Kojima H....Keppler D. (2003)
Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl. (PubMed id 9681826)^{1, 3} Takahashi K....Takai Y. (1998)
A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites. (PubMed id 1429901)^{1, 3} Sato N....Tsukita S. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5962	HGNC: 9944	AceView: RDX	Ensembl:ENSG00000137710	euGenes: HUgn5962
ECgene: RDX	H-InvDB: RDX

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for RDX
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RDX:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RDX-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RDX		Antibodies for RDX
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RDX		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RDX)
	Antibodies (RDX)
	Chimera RNAi (RDX)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for RDX (Radixin)

	Recombinant Proteins (Ezrin / Radixin / Moesin, Radixin)
	Antibodies (Ezrin / Radixin / Moesin, Radixin)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for RDX

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RDX

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
RDX Gene at Home site.
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RDX Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for RDX

Summaries
for RDX

Genomic Location
for RDX

Proteins
for RDX

Protein Domains/
Families
for RDX

Gene Function
for RDX

Pathways & Interactions
for RDX

Drugs & Compounds
for RDX

Transcripts
for RDX

Expression
for RDX

Orthologs
for RDX

Paralogs
for RDX

SNPs/Variants
for RDX

Disorders & Mutations
for RDX

Medical News
for RDX

Publications
for RDX

Search for RDX

Genome Databases showing RDX

Other Databases showing RDX

Specialized Databases showing RDX

Licensable Technologies
for RDX

Services
for RDX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RDX Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor RDX

Summariesfor RDX

Genomic Locationfor RDX

Proteinsfor RDX

Protein Domains/Familiesfor RDX

Gene Functionfor RDX

Pathways & Interactionsfor RDX

Drugs & Compoundsfor RDX

Transcriptsfor RDX

Expression for RDX

Orthologsfor RDX

Paralogsfor RDX

SNPs/Variantsfor RDX

Disorders & Mutationsfor RDX

Medical Newsfor RDX

Publicationsfor RDX

Search for RDX

Genome Databases showing RDX

Other Databases showing RDX

Specialized Databases showing RDX

Licensable Technologiesfor RDX

Servicesfor RDX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RDX

Summaries
for RDX

Genomic Location
for RDX

Proteins
for RDX

Protein Domains/
Families
for RDX

Gene Function
for RDX

Pathways & Interactions
for RDX

Drugs & Compounds
for RDX

Transcripts
for RDX

Expression
for RDX

Orthologs
for RDX

Paralogs
for RDX

SNPs/Variants
for RDX

Disorders & Mutations
for RDX

Medical News
for RDX

Publications
for RDX

Licensable Technologies
for RDX

Services
for RDX