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Aliases for RDM1 Gene

Aliases for RDM1 Gene

  • RAD52 Motif Containing 1 2 3 5
  • RAD52 Homolog B 3 4
  • RAD52 Motif 1 2 3
  • RAD52B 3 4
  • RAD52 Homolog B (S. Cerevisiae) 2

External Ids for RDM1 Gene

Previous HGNC Symbols for RDM1 Gene

  • RAD52B

Previous GeneCards Identifiers for RDM1 Gene

  • GC17M031270
  • GC17M034246
  • GC17M030430
  • GC17M034248
  • GC17M034274
  • GC17M034305
  • GC17M034332
  • GC17M034383

Summaries for RDM1 Gene

Entrez Gene Summary for RDM1 Gene

  • This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RDM1 Gene

RDM1 (RAD52 Motif Containing 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for RDM1 Gene

  • May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RDM1 Gene

Genomics for RDM1 Gene

Regulatory Elements for RDM1 Gene

Promoters for RDM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RDM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RDM1 Gene

Chromosome:
17
Start:
35,918,066 bp from pter
End:
35,930,811 bp from pter
Size:
12,746 bases
Orientation:
Minus strand

Genomic View for RDM1 Gene

Genes around RDM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RDM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RDM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RDM1 Gene

Proteins for RDM1 Gene

neXtProt entry for RDM1 Gene

Proteomics data for RDM1 Gene at MOPED

Post-translational modifications for RDM1 Gene

  • Ubiquitination at Lys 100 and Lys 197
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RDM1 Gene

Domains & Families for RDM1 Gene

Gene Families for RDM1 Gene

Protein Domains for RDM1 Gene

Suggested Antigen Peptide Sequences for RDM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NG50

UniProtKB/Swiss-Prot:

RDM1_HUMAN :
  • C-terminal half (amino acids 134-284) contains cytoplasmic retention domains as well as determinants involved in its stress-induced nucleolar accumulation.
Domain:
  • C-terminal half (amino acids 134-284) contains cytoplasmic retention domains as well as determinants involved in its stress-induced nucleolar accumulation.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RDM1: view

Function for RDM1 Gene

Molecular function for RDM1 Gene

UniProtKB/Swiss-Prot Function:
May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA.
UniProtKB/Swiss-Prot Induction:
Heat-shock stress up-regulated mRNA expression of isoform 10 and isoform 11. Heat-shock stress down-regulated short N-terminal mRNA expression of isoform 2, isoform 4, isoform 6 and isoform 9.

Gene Ontology (GO) - Molecular Function for RDM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with RDM1: view
genes like me logo Genes that share phenotypes with RDM1: view

miRNA for RDM1 Gene

miRTarBase miRNAs that target RDM1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RDM1 Gene

Localization for RDM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RDM1 Gene

Nucleus. Cytoplasm. Nucleus, nucleolus. Note=Isoform 3 and isoform 10 are predominantly nuclear and nucleolar. After treatment with proteasomal inhibitors and mild heat-shock stress, isoform 1, isoform 3, isoform 5, isoform 7, isoform 8 and isoform 10 are relocalized to the nucleolus as dot-like or irregular subnuclear structures. Isoform 1 colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress. Isoform 3, but not isoform 1 and isoform 5, is relocalized in nucleolar caps during transcriptional arrest.
Isoform 1: Cytoplasm. Nucleus, PML body. Nucleus, Cajal body. Note=Isoform 1 is predominantly cytoplasmic. Isoform 1 colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RDM1 Gene COMPARTMENTS Subcellular localization image for RDM1 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RDM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RDM1: view

Pathways & Interactions for RDM1 Gene

SuperPathways for RDM1 Gene

No Data Available

Interacting Proteins for RDM1 Gene

Selected Interacting proteins: Q8NG50-RDM1_HUMAN for RDM1 Gene via UniProtKB

Symbol External ID(s) Details
MRFAP1L1

Gene Ontology (GO) - Biological Process for RDM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RDM1 Gene

Drugs & Compounds for RDM1 Gene

No Compound Related Data Available

Transcripts for RDM1 Gene

Unigene Clusters for RDM1 Gene

RAD52 motif 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RDM1 Gene

No ASD Table

Relevant External Links for RDM1 Gene

GeneLoc Exon Structure for
RDM1
ECgene alternative splicing isoforms for
RDM1

Expression for RDM1 Gene

mRNA expression in normal human tissues for RDM1 Gene

mRNA differential expression in normal tissues according to GTEx for RDM1 Gene

This gene is overexpressed in Testis (x24.0).

SOURCE GeneReport for Unigene cluster for RDM1 Gene Hs.194411

mRNA Expression by UniProt/SwissProt for RDM1 Gene

Q8NG50-RDM1_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with RDM1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RDM1 Gene

Orthologs for RDM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RDM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RDM1 35
  • 99.18 (n)
  • 98.59 (a)
cow
(Bos Taurus)
Mammalia LOC513486 35
  • 85.45 (n)
  • 78.87 (a)
dog
(Canis familiaris)
Mammalia LOC100683711 35
  • 82.31 (n)
  • 79.23 (a)
mouse
(Mus musculus)
Mammalia Rdm1 35
  • 76.41 (n)
  • 72.92 (a)
Rdm1 16
rat
(Rattus norvegicus)
Mammalia Rdm1 35
  • 77.02 (n)
  • 72.56 (a)
chicken
(Gallus gallus)
Aves RDM1 35
  • 61.55 (n)
  • 55.81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rdm1 35
  • 59.57 (n)
  • 50.18 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:103564 35
  • 50.13 (n)
  • 38.55 (a)
Species with no ortholog for RDM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RDM1 Gene

ENSEMBL:
Gene Tree for RDM1 (if available)
TreeFam:
Gene Tree for RDM1 (if available)

Paralogs for RDM1 Gene

No data available for Paralogs for RDM1 Gene

Variants for RDM1 Gene

Sequence variations from dbSNP and Humsavar for RDM1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2280786 - 35,930,633(-) TTTGC(A/G)TGTGA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs2251660 - 35,925,533(-) GGGTG(G/T)TCCAA nc-transcript-variant, reference, missense
rs2214606 -- 35,925,153(+) caaaa(C/T)aaaaa intron-variant
rs2526324 -- 35,918,838(+) ACAGC(C/T)ATTGT intron-variant
rs2526325 -- 35,920,214(+) TCTTC(A/G)CATCT intron-variant, nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RDM1 Gene

Variant ID Type Subtype PubMed ID
nsv2039 CNV Insertion 18451855
nsv833424 CNV Gain 17160897

Variation tolerance for RDM1 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.97; 89.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RDM1 Gene

HapMap Linkage Disequilibrium report
RDM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RDM1 Gene

Disorders for RDM1 Gene

Relevant External Links for RDM1

Genetic Association Database (GAD)
RDM1
Human Genome Epidemiology (HuGE) Navigator
RDM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RDM1

No disorders were found for RDM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RDM1 Gene

Publications for RDM1 Gene

  1. RDM1, a novel RNA recognition motif (RRM)-containing protein involved in the cell response to cisplatin in vertebrates. (PMID: 15611051) Hamimes S. … Van Dyck E. (J. Biol. Chem. 2005) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Subcellular distribution of human RDM1 protein isoforms and their nucleolar accumulation in response to heat shock and proteotoxic stress. (PMID: 17905820) Messaoudi L. … Van Dyck E. (Nucleic Acids Res. 2007) 3

Products for RDM1 Gene

Sources for RDM1 Gene

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