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RDH8 Gene

protein-coding   GIFtS: 52
GCID: GC19P010123

Retinol Dehydrogenase 8 (All-Trans)

  See RDH8-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Retinol Dehydrogenase 8 (All-Trans)1 2     SDR28C22
PRRDH2 3 5     Retinol Dehydrogenase 82
Photoreceptor Outer Segment All-Trans Retinol Dehydrogenase2 3     Short Chain Dehydrogenase/Reductase Family 28C, Member 22
Member 21     EC 1.1.1.3003
Short Chain Dehydrogenase/Reductase Family 28C1     

External Ids:    HGNC: 144231   Entrez Gene: 507002   Ensembl: ENSG000000805117   OMIM: 6085755   UniProtKB: Q9NYR83   

Export aliases for RDH8 gene to outside databases

Previous GC identifers: GC19P010245 GC19P010346 GC19P009969 GC19P009984 GC19P009704


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RDH8 Gene:
This gene encodes a member of the short-chain dehydrogenase/reductase family. The encoded protein catalyzes the
reduction of all-trans-retinal to all-trans-retinol, the first reaction step of the rhodopsin regeneration
pathway. This enzymatic reaction is the rate-limiting step in the visual cycle. (provided by RefSeq, Feb 2014)

GeneCards Summary for RDH8 Gene:
RDH8 (retinol dehydrogenase 8 (all-trans)) is a protein-coding gene. Diseases associated with RDH8 include leber congenital amaurosis. GO annotations related to this gene include NADP-retinol dehydrogenase activity and retinol dehydrogenase activity. An important paralog of this gene is SDR9C7.

UniProtKB/Swiss-Prot: RDH8_HUMAN, Q9NYR8
Function: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol.
May play a role in the regeneration of visual pigment at high light intensity (By similarity)

Gene Wiki entry for RDH8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RDH8 gene promoter:
         Sp1   NRSF form 1   AP-2gamma   NRSF form 2   AP-2beta   AP-2alpha   ATF   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRDH8 promoter sequence
   Search Chromatin IP Primers for RDH8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RDH8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

RDH8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RDH8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010123:  view genomic region     (about GC identifiers)

Start:
10,123,925 bp from pter      End:
10,132,955 bp from pter
Size:
9,031 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RDH8_HUMAN, Q9NYR8 (See protein sequence)
Recommended Name: Retinol dehydrogenase 8  
Size: 311 amino acids; 33755 Da
Sequence caution: Sequence=BAB14782.1; Type=Frameshift; Positions=26;
Secondary accessions: Q9H838

Explore the universe of human proteins at neXtProt for RDH8: NX_Q9NYR8

Explore proteomics data for RDH8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RDH8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056540.2  
    ENSEMBL proteins: 
     ENSP00000466058   ENSP00000465773   ENSP00000171214  
    Reactome Protein details: Q9NYR8

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    antibodies-online proteins for RDH8 (2 products) 

     
    antibodies-online peptides for RDH8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRC2: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 2

    5 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR011348 17beta_DH
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9NYR8

    ProtoNet protein and cluster: Q9NYR8

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: RDH8_HUMAN, Q9NYR8
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    Find genes that share domains with RDH8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RDH8_HUMAN, Q9NYR8
    Function: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol.
    May play a role in the regeneration of visual pigment at high light intensity (By similarity)
    Catalytic activity: All-trans-retinol + NADP(+) = all-trans-retinal + NADPH

         Enzyme Number (IUBMB): EC 1.1.1.3001

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004303estradiol 17-beta-dehydrogenase activity IEA--
    GO:0004745retinol dehydrogenase activity TAS10753906
    GO:0016491oxidoreductase activity ----
    GO:0052650NADP-retinol dehydrogenase activity IEA--
         
    Find genes that share ontologies with RDH8           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rdh8):
     cardiovascular system  nervous system  pigmentation  vision/eye 

    Find genes that share phenotypes with RDH8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rdh8tm1Kpal for RDH8

       genOway: Develop your customized and physiologically relevant rodent model for RDH8

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    1 qRT-PCR Assays for microRNA that regulate RDH8:
    hsa-miR-138
    SwitchGear 3'UTR luciferase reporter plasmidRDH8 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RDH8_HUMAN, Q9NYR8: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    extracellular2
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005887integral component of plasma membrane TAS10753906

    Find genes that share ontologies with RDH8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RDH8 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1the visual cycle I (vertebrates)
    the visual cycle I (vertebrates)0.52
    The canonical retinoid cycle in rods (twilight vision)0.44
    retinol biosynthesis0.52
    2Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    3Signaling by GPCR
    Signal Transduction0.58
    4Metabolism
    Metabolic pathways0.38
    5Chemical carcinogenesis
    Retinol metabolism0.35


    Find genes that share SuperPaths with RDH8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RDH8
        Visual Cycle in Retinal Rods

    3 BioSystems Pathways for RDH8
        Vitamin A and carotenoid metabolism
    retinol biosynthesis
    the visual cycle I (vertebrates)

    1 Reactome Pathway for RDH8
        The canonical retinoid cycle in rods (twilight vision)


    2 Kegg Pathways  (Kegg details for RDH8):
        Retinol metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RDH8
    Interactions:

        Search GeneGlobe Interaction Network for RDH8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for RDH8 (ENSP000001712144) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCMO1ENSP000002581684STRING: ENSP00000258168
    DGAT1ENSP000003322584STRING: ENSP00000332258
    LRATENSP000003372244STRING: ENSP00000337224
    RETSATENSP000002958024STRING: ENSP00000295802
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0006694steroid biosynthetic process TAS10753906
    GO:0006703estrogen biosynthetic process IEA--
    GO:0007601visual perception IEA--
    GO:0007603phototransduction, visible light TAS--

    Find genes that share ontologies with RDH8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RDH8

    2 HMDB Compounds for RDH8    About this table
    CompoundSynonyms CAS #PubMed Ids
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    1 DrugBank Compound for RDH8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin A[11,12-3H]-Retinol (see all 18)68-26-8target--17081426 14718298 17139284 17016423 14661078

    1 Novoseek inferred chemical compound relationship for RDH8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin a 72.9 12 17081426 (2), 14661078 (2), 10753906 (1), 14718298 (1) (see all 7)



    Find genes that share compounds with RDH8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RDH8 gene: 
    NM_015725.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591589 ENST00000589570 ENST00000587782 ENST00000171214(uc002mmr.3)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate RDH8:
    hsa-miR-138
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    14 AceView cDNA sequences:

    AF229845 BQ636682 AL711436 NM_015725 AK024022 BE391293 AU143000 BE389836 
    BM672353 BE728421 BM701029 AU160174 BG280953 BQ226139 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RDH8    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b
    SP1:                                      -                           
    SP2:                                      -     -                     
    SP3:                    -                                             


    ECgene alternative splicing isoforms for RDH8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RDH8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATACACCAG
    RDH8 Expression
    About this image

    RDH8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RDH8 Protein Expression

    UniProtKB/Swiss-Prot: RDH8_HUMAN, Q9NYR8
    Tissue specificity: Detected in photoreceptor outer segments in the retina (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RDH8 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rdh81 , 5 retinol dehydrogenase 81, 5 82.1(n)1
    82.96(a)1
      9 (7.64 cM)5
    2350331  NM_001030290.11  NP_001025461.11 
     208185045 
    chicken
    (Gallus gallus)
    Aves LOC1008582931 retinol dehydrogenase 8-like 61.94(n)
    58.45(a)
      100858293  XM_003642807.1  XP_003642855.1 
    lizard
    (Anolis carolinensis)
    Reptilia RDH86
    retinol dehydrogenase 8 (all-trans)
    61(a)
    1 ↔ 1
    GL343252.1(1847896-1882311)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004915691 retinol dehydrogenase 8-like 59.46(n)
    55.74(a)
      100491569  XM_002940371.2  XP_002940417.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc730812 hypothetical protein MGC73081 72.34(n)   393680  AY306007.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sro6
    shroud
    20(a)
    1 → many
    3R(25620358-25621420)


    ENSEMBL Gene Tree for RDH8 (if available)
    TreeFam Gene Tree for RDH8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RDH8 gene
    SDR9C72  DHRS92  HSD11B22  HSD17B62  HSD17B22  BDH12  RDH162  DHRS7B2  
    DHRS72  HSD17B12  KDSR2  DHRS7C2  RDH52  
    4 SIMAP similar genes for RDH8 using alignment to 3 protein entries:     RDH8_HUMAN (see all proteins):
    17BHSDI    HSD17B1    DHRS4L2    BDH1

    Find genes that share paralogs with RDH8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RDH8 (see all 300)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1810806001,2
    --10123257(+) CCCAGA/CATACA 1 -- us2k10--------
    rs556345071,2
    --10123343(+) TCATGC/TTTGTA 1 -- us2k10--------
    rs1407292931,2
    --10123408(+) AGACCA/GGCCTG 1 -- us2k10--------
    rs1857296341,2
    C--10123622(+) ATAATA/TTACAG 1 -- us2k10--------
    rs1385484691,2
    --10123692(+) TTGAGG/TCCAAG 1 -- us2k10--------
    rs22337891,2
    C,F,A,H--10123702(+) GAGTTC/TGAGAC 1 -- us2k17Minor allele frequency- T:0.36NA EA 250
    rs1915309161,2
    --10123783(+) GTGTGC/TGCCGG 1 -- us2k10--------
    rs1838466961,2
    --10123801(+) AGCTAA/CTCTGG 1 -- us2k10--------
    rs1175730221,2
    F--10123806(+) CTCTGG/CAGGCT 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1871067091,2
    --10123839(+) CTGTGG/TTGAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RDH8 (10123925 - 10132955 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RDH8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833742CNV Loss17160897
    nsv911027CNV Loss21882294
    dgv3724n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RDH8
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608575    OMIM disorders: --

    1 disease for RDH8:    
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    leber congenital amaurosis

    2 diseases from the University of Copenhagen DISEASES database for RDH8:
    Retinal degeneration     Fundus dystrophy

    Find genes that share disorders with RDH8           About GenesLikeMe

    2 Novoseek inferred disease relationships for RDH8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    eye diseases 58.4 2 17081426 (1), 14661078 (1)
    myopia 50.8 2 17081426 (1), 14661078 (1)

    Genetic Association Database (GAD): RDH8
    Human Genome Epidemiology (HuGE) Navigator: RDH8 (1 document)

    Export disorders for RDH8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RDH8 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with RDH8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol. (PubMed id 10753906)1, 2, 3, 9 Rattner A.... Nathans J. (J. Biol. Chem. 2000)
    2. Investigation of the association between all-trans-retinol dehydrogenase (RDH8) polymorphisms and high myopia in Chinese. (PubMed id 21043051)1, 4 Yu Y.S....Han W. (J Zhejiang Univ Sci B 2010)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. (PubMed id 15755727)1, 9 Maeda A....Palczewski K. (J. Biol. Chem. 2005)
    6. Using denaturing HPLC for SNP discovery and genotyping, and establishing the linkage disequilibrium pattern for the all-trans-retinol dehydrogenase (RDH8) gene. (PubMed id 14661078)7, 9 Han W....Yap M.K. (J. Hum. Genet. 2004)
    7. [Establishing the linkage disequilibrium pattern for the all-trans-retinol dehydrogenase (RDH8) gene]. (PubMed id 17081426)7, 9 Han W....Yap M.K. (Zhonghua Yan Ke Za Zhi 2006)
    8. Novel mutations in the cellular retinaldehyde-binding protein gene (RLBP1) associated with retinitis punctata albescens: evidence of interfamilial genetic heterogeneity and fundus changes in heterozygotes. (PubMed id 14718298)7, 9 Fishman G.A....Dryja T.P. (Arch. Ophthalmol. 2004)
    9. Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage. (PubMed id 22220722)1 Okano K....Maeda T. (J. Neurochem. 2012)
    10. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50700 HGNC: 14423 AceView: RDH8 Ensembl:ENSG00000080511 euGenes: HUgn50700
    ECgene: RDH8 Kegg: 50700 H-InvDB: RDH8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RDH8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RDH8 gene:
    Search GeneIP for patents involving RDH8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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