Aliases for RDH8 Gene
External Ids for RDH8 Gene
Previous GeneCards Identifiers for RDH8 Gene
This gene encodes a member of the short-chain dehydrogenase/reductase family. The encoded protein catalyzes the reduction of all-trans-retinal to all-trans-retinol, the first reaction step of the rhodopsin regeneration pathway. This enzymatic reaction is the rate-limiting step in the visual cycle. [provided by RefSeq, Feb 2014]
GeneCards Summary for RDH8 Gene
RDH8 (Retinol Dehydrogenase 8 (All-Trans)) is a Protein Coding gene. Diseases associated with RDH8 include leber congenital amaurosis. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include retinol dehydrogenase activity and NADP-retinol dehydrogenase activity. An important paralog of this gene is HSD11B2.
UniProtKB/Swiss-Prot for RDH8 Gene
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity).