Aliases for RDH8 Gene
External Ids for RDH8 Gene
Previous GeneCards Identifiers for RDH8 Gene
This gene encodes a member of the short-chain dehydrogenase/reductase family. The encoded protein catalyzes the reduction of all-trans-retinal to all-trans-retinol, the first reaction step of the rhodopsin regeneration pathway. This enzymatic reaction is the rate-limiting step in the visual cycle. [provided by RefSeq, Feb 2014]
GeneCards Summary for RDH8 Gene
RDH8 (Retinol Dehydrogenase 8 (All-Trans)) is a Protein Coding gene. Diseases associated with RDH8 include Myopia and Stargardt Disease. Among its related pathways are the visual cycle I (vertebrates) and Metabolism of fat-soluble vitamins. GO annotations related to this gene include oxidoreductase activity and estradiol 17-beta-dehydrogenase activity. An important paralog of this gene is HSD17B1.
UniProtKB/Swiss-Prot for RDH8 Gene
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity).