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Aliases for RDH16 Gene

Aliases for RDH16 Gene

  • Retinol Dehydrogenase 16 (All-Trans) 2 3
  • Short Chain Dehydrogenase/Reductase Family 9C Member 8 3 4
  • Microsomal NAD(+)-Dependent Retinol Dehydrogenase 4 3 4
  • Retinol Dehydrogenase 16 (All-Trans And 13-Cis) 2 3
  • Sterol/Retinol Dehydrogenase 3 4
  • RODH-4 3 4
  • SDR9C8 3 4
  • Short Chain Dehydrogenase/Reductase Family 9C, Member 8 3
  • Microsomal NAD+ Dependent Retinol Dehydrogenase 4 2
  • Microsomal NAD+-Dependent Retinol Dehydrogenase 4 3
  • Short Chain Dehydrogenase/Reductase Family 9C 2
  • Retinol Dehydrogenase 16 3
  • EC 1.1.1.105 64
  • EC 1.1.-.- 4
  • Member 8 2
  • EC 1.1.1 64
  • RODH4 4

External Ids for RDH16 Gene

Summaries for RDH16 Gene

GeneCards Summary for RDH16 Gene

RDH16 (Retinol Dehydrogenase 16 (All-Trans)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include electron carrier activity and retinol dehydrogenase activity. An important paralog of this gene is HSD11B2.

UniProtKB/Swiss-Prot for RDH16 Gene

  • Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RDH16 Gene

Genomics for RDH16 Gene

Genomic Location for RDH16 Gene

Start:
56,951,431 bp from pter
End:
56,959,374 bp from pter
Size:
7,944 bases
Orientation:
Minus strand

Genomic View for RDH16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RDH16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RDH16 Gene

Regulatory Elements for RDH16 Gene

Proteins for RDH16 Gene

  • Protein details for RDH16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75452-RDH16_HUMAN
    Recommended name:
    Retinol dehydrogenase 16
    Protein Accession:
    O75452
    Secondary Accessions:
    • Q9UNV2

    Protein attributes for RDH16 Gene

    Size:
    317 amino acids
    Molecular mass:
    35673 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RDH16 Gene

Proteomics data for RDH16 Gene at MOPED

Selected DME Specific Peptides for RDH16 Gene

Post-translational modifications for RDH16 Gene

Other Protein References for RDH16 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for RDH16 Gene

Gene Families for RDH16 Gene

HGNC:
  • SDRC2 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 2

UniProtKB/Swiss-Prot:

RDH16_HUMAN
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.:
    • O75452
genes like me logo Genes that share domains with RDH16: view

Function for RDH16 Gene

Molecular function for RDH16 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.14 uM for androsterone {ECO:0000269 PubMed:9677409}; KM=0.22 uM for androstanediol {ECO:0000269 PubMed:9677409}; KM=0.80 uM for dihydrotestosterone {ECO:0000269 PubMed:9677409}; KM=0.13 uM for NAD {ECO:0000269 PubMed:9677409}; KM=190 uM for NADP {ECO:0000269 PubMed:9677409};
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by citral, perillyl alcohol, geraniol, farnesol and geranyl geraniol.
UniProtKB/Swiss-Prot Function: Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction.
UniProtKB/Swiss-Prot Induction: Transiently up-regulated by retinoic acid.

Enzyme Numbers (IUBMB) for RDH16 Gene

Gene Ontology (GO) - Molecular Function for RDH16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004745 retinol dehydrogenase activity TAS 9677409
GO:0009055 electron carrier activity TAS 9677409
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with RDH16: view

miRNA for RDH16 Gene

miRTarBase miRNAs that target RDH16

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RDH16 Gene

Localization for RDH16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RDH16 Gene

Microsome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RDH16 Gene COMPARTMENTS Subcellular localization image for RDH16 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 3
extracellular 2
cytosol 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RDH16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle TAS 9677409
genes like me logo Genes that share ontologies with RDH16: view

Pathways for RDH16 Gene

genes like me logo Genes that share pathways with RDH16: view

Pathways by source for RDH16 Gene

Interacting Proteins for RDH16 Gene

Gene Ontology (GO) - Biological Process for RDH16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 9677409
GO:0008152 metabolic process --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with RDH16: view

Compounds for RDH16 Gene

(4) HMDB Compounds for RDH16 Gene

Compound Synonyms Cas Number PubMed IDs
Androstanediol
  • Androstane-3,17-diol
25126-76-5
Androsterone
  • (3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one
53-41-8
Farnesol
  • 2-cis,6-trans-Farnesol
4602-84-0
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
genes like me logo Genes that share compounds with RDH16: view

Transcripts for RDH16 Gene

Unigene Clusters for RDH16 Gene

Retinol dehydrogenase 16 (all-trans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RDH16 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for RDH16 Gene

GeneLoc Exon Structure for
RDH16
ECgene alternative splicing isoforms for
RDH16

Expression for RDH16 Gene

mRNA expression in normal human tissues for RDH16 Gene

mRNA differential expression in normal tissues according to GTEx for RDH16 Gene

This gene is overexpressed in Liver (47.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RDH16 Gene

SOURCE GeneReport for Unigene cluster for RDH16 Gene Hs.134958

mRNA Expression by UniProt/SwissProt for RDH16 Gene

O75452-RDH16_HUMAN
Tissue specificity: Highly expressed in adult liver (at protein level). Detected in endometrium, liver and foreskin. Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers. Detected in fetal liver and lung.
genes like me logo Genes that share expressions with RDH16: view

Orthologs for RDH16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RDH16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RDH16 36
  • 99.16 (n)
  • 99.05 (a)
RDH16 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RDH16 36
  • 81.91 (n)
  • 79.18 (a)
RDH16 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RDH16 36
  • 80.86 (n)
  • 76.97 (a)
RDH16 37
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC089597 37
  • 69 (a)
OneToMany
Rdh1 36
  • 78.65 (n)
  • 74.13 (a)
Rdh1 37
  • 74 (a)
OneToMany
Rdh16 37
  • 73 (a)
OneToMany
Rdh19 37
  • 71 (a)
OneToMany
Rdh7 16
Rdh7 37
  • 73 (a)
OneToMany
Rdh9 37
  • 72 (a)
OneToMany
RP23-386P10.11 37
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RDH16 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 67 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rdh16 36
  • 78.02 (n)
  • 70.66 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 59 (a)
OneToMany
LOC776432 36
  • 64.91 (n)
  • 61.18 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 60 (a)
ManyToMany
-- 37
  • 61 (a)
ManyToMany
-- 37
  • 58 (a)
ManyToMany
-- 37
  • 59 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 61 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 56 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rdh16 36
  • 62.64 (n)
  • 59.8 (a)
zebrafish
(Danio rerio)
Actinopterygii dhrs9 36
  • 58.46 (n)
  • 52.37 (a)
dhrs9 37
  • 52 (a)
OneToMany
wufb64b07 36
Species with no ortholog for RDH16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RDH16 Gene

ENSEMBL:
Gene Tree for RDH16 (if available)
TreeFam:
Gene Tree for RDH16 (if available)

Paralogs for RDH16 Gene

Selected SIMAP similar genes for RDH16 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RDH16 Gene

genes like me logo Genes that share paralogs with RDH16: view

Variants for RDH16 Gene

Sequence variations from dbSNP and Humsavar for RDH16 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs703819 -- 56,959,051(-) ttgca(A/G)aacag upstream-variant-2KB, utr-variant-5-prime
rs703820 -- 56,955,697(-) GGAAA(C/G)AGGAT intron-variant
rs746049 -- 56,955,255(-) CTGCC(C/T)TCACT intron-variant
rs901068 -- 56,953,021(-) CCCGA(A/C)GTTTT intron-variant
rs901069 -- 56,952,595(-) CGTTA(C/T)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RDH16 Gene

Variant ID Type Subtype PubMed ID
esv24053 CNV Gain+Loss 19812545
dgv1427n71 CNV Gain 21882294
nsv436148 CNV Deletion 17901297
nsv512276 CNV Loss 21212237
nsv832428 CNV Gain 17160897
nsv516039 CNV Loss 19592680

Relevant External Links for RDH16 Gene

HapMap Linkage Disequilibrium report
RDH16

Disorders for RDH16 Gene

No disorders were found for RDH16 Gene.

No data available for UniProtKB/Swiss-Prot for RDH16 Gene

Publications for RDH16 Gene

  1. cDNA cloning and characterization of a new human microsomal NAD+- dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha- hydroxysteroids. (PMID: 9677409) Gough W.H. … Kedishvili N.Y. (J. Biol. Chem. 1998) 2 3 4 23
  2. Cloning and characterization of retinol dehydrogenase transcripts expressed in human epidermal keratinocytes. (PMID: 10329026) Jurukovski V. … Simon M. (Mol. Genet. Metab. 1999) 2 3 4
  3. Expression of a retinol dehydrogenase (hRoDH-4), a member of the retinol/steroid dehydrogenase family implicated in retinoic acid biosynthesis, in normal and neoplastic endometria. (PMID: 11967490) Cain J.M. … Weisz J. (Am. J. Obstet. Gynecol. 2002) 3 4
  4. Differential recognition of the free versus bound retinol by human microsomal retinol/sterol dehydrogenases: characterization of the holo-CRBP dehydrogenase activity of RoDH-4. (PMID: 12534290) Lapshina E.A. … Kedishvili N.Y. (Biochemistry 2003) 3 4
  5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3

Products for RDH16 Gene

Sources for RDH16 Gene

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