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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RDH16 Gene

protein-coding   GIFtS: 51
GCID: GC12M057346

Retinol Dehydrogenase 16 (All-Trans)

(Previous name: retinol dehydrogenase 16 (all-trans and 13-cis))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Retinol Dehydrogenase 16 (All-Trans)1 2     Microsomal NAD+-Dependent Retinol Dehydrogenase 42
Retinol Dehydrogenase 16 (All-Trans And 13-Cis)1 2     Retinol Dehydrogenase 162
Microsomal NAD(+)-Dependent Retinol Dehydrogenase 42 3     Short Chain Dehydrogenase/Reductase Family 9C, Member 82
Sterol/Retinol Dehydrogenase2 3     EC 1.1.-.-3
Member 81     RODH43
Microsomal NAD+ Dependent Retinol Dehydrogenase 41     RoDH-43
Short Chain Dehydrogenase/Reductase Family 9C1     EC 1.1.18
RODH-42     EC 1.1.1.1058
SDR9C82     

External Ids:    HGNC: 296741   Entrez Gene: 86082   Ensembl: ENSG000001395477   UniProtKB: O754523   

Export aliases for RDH16 gene to outside databases

Previous GC identifers: GC12M055632 GC12M054383


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RDH16 Gene: 
RDH16 (retinol dehydrogenase 16 (all-trans)) is a protein-coding gene. Diseases associated with RDH16 include cytochrome p450, and tuberculosis, and among its related super-pathways are Metabolism and Drug metabolism - cytochrome P450. GO annotations related to this gene include retinol dehydrogenase activity and nucleotide binding. An important paralog of this gene is SDR9C7.

UniProtKB/Swiss-Prot: RDH16_HUMAN, O75452
Function: Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol and 13-cis-retinol to the
corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes
3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can
also catalyze the reverse reaction




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RDH16 gene promoter:
         SRF   c-Fos   USF1   AP-1   SRF (504 AA)   USF2   USF-1:USF-2   YY1   USF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRDH16 promoter sequence
   Search SABiosciences Chromatin IP Primers for RDH16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RDH16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

RDH16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RDH16 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M057346:  view genomic region     (about GC identifiers)

Start:
57,345,215 bp from pter      End:
57,353,158 bp from pter
Size:
7,944 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RDH16_HUMAN, O75452 (See protein sequence)
Recommended Name: Retinol dehydrogenase 16  
Size: 317 amino acids; 35673 Da
Subcellular location: Microsome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane;
Single-pass type IV membrane protein (Potential)
Secondary accessions: Q9UNV2

Explore the universe of human proteins at neXtProt for RDH16: NX_O75452

Explore proteomics data for RDH16 at MOPED 

Post-translational modifications:

  • UniProtKB: Not N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75452

  • 4/5 DME Specific Peptides for RDH16 (O75452) (see all 5)
     GVEAFSD  GLVNNAG  TGCDSGFG  EAFSDSLRR 

    RDH16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RDH16 Protein Expression
    REFSEQ proteins: NP_003699.3  
    ENSEMBL proteins: 
     ENSP00000381206  

    Human Recombinant Protein Products for RDH16: 
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    Cloud-Clone Corp. Proteins for RDH16 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0043231intracellular membrane-bounded organelle TAS9677409

    RDH16 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SDRC2: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 2

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry O75452

    ProtoNet protein and cluster: O75452

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: RDH16_HUMAN, O75452
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    RDH16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RDH16_HUMAN, O75452
    Function: Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol and 13-cis-retinol to the
    corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes
    3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can
    also catalyze the reverse reaction
    Enzyme regulation: Inhibited by citral, perillyl alcohol, geraniol, farnesol and geranyl geraniol
    Biophysicochemical properties: Kinetic parameters: KM=0.14 uM for androsterone; KM=0.22 uM for androstanediol;
    KM=0.80 uM for dihydrotestosterone; KM=0.13 uM for NAD; KM=190 uM for NADP;
    Induction: Transiently up-regulated by retinoic acid

         Enzyme Numbers (IUBMB): EC 1.1.-.-1 EC 1.1.12 EC 1.1.1.1052

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004745retinol dehydrogenase activity TAS9677409
    GO:0009055electron carrier activity TAS9677409
    GO:0016491oxidoreductase activity ----
         
    RDH16 for ontologies           About GeneDecksing


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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RDH16 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Drug metabolism - cytochrome P450
    Retinol metabolism0.39
    3retinoate biosynthesis II
    retinoate biosynthesis I0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RDH16
        retinoate biosynthesis I


    2         Kegg Pathways  (Kegg details for RDH16):
        Retinol metabolism
    Metabolic pathways


    RDH16 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RDH16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for RDH16 (ENSP000003812064) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    ALDH1A3ENSP000003322564STRING: ENSP00000332256
    CYP26A1ENSP000002243564STRING: ENSP00000224356
    LRATENSP000003372244STRING: ENSP00000337224
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS9677409
    GO:0008152metabolic process ----

    RDH16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RDH16

    4 HMDB Compounds for RDH16    About this table
    CompoundSynonyms CAS #PubMed Ids
    Androsterone(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one (see all 28)53-41-812646198
    AndrostanediolAndrostane-3,17-diol (see all 10)25126-76-5--
    Farnesol2-cis,6-trans-Farnesol (see all 7)4602-84-0--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--

    Search CenterWatch for drugs/clinical trials and news about RDH16

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RDH16 gene: 
    NM_003708.3  

    Unigene Cluster for RDH16:

    Retinol dehydrogenase 16 (all-trans)
    Hs.134958  [show with all ESTs]
    Unigene Representative Sequence: AB209332
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398138(uc001smi.4 uc009zpa.3) ENST00000360752
    miRNA
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    hsa-miR-3909
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB209332.1 AF057034.1 AF086735.1 AK311025.1 DQ499468.1 

    6 DOTS entries:

    DT.97834399  DT.65288228  DT.40244852  DT.95335282  DT.40191150  DT.95335279 

    24/25 AceView cDNA sequences (see all 25):

    AV647258 CB163679 BM825775 BM772123 AA312392 AF057034 BM753987 BM742307 
    AV647688 AV647598 AW449664 CB111911 AI093928 AF086735 AI439848 NM_003708 
    AV647479 T50791 AV661181 T68870 T67674 H61508 AW905448 AV661130 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RDH16    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4
    SP1:                        
    SP2:        -               


    ECgene alternative splicing isoforms for RDH16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RDH16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTGGGGT
    RDH16 Expression
    About this image


    See RDH16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RDH16

    SOURCE GeneReport for Unigene cluster: Hs.134958

    UniProtKB/Swiss-Prot: RDH16_HUMAN, O75452
    Tissue specificity: Highly expressed in adult liver (at protein level). Detected in endometrium, liver and
    foreskin. Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers.
    Detected in fetal liver and lung

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RDH16 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rdh71 , 5 retinol dehydrogenase 71, 5 78.06(n)1
    72.78(a)1
      10 (76.39 cM)5
    541501  NM_001150749.11  NP_001144221.11 
     1278840285 
    chicken
    (Gallus gallus)
    Aves LOC7764321 retinol dehydrogenase 16-like 67.78(n)
    63.1(a)
      776432  XM_001235954.2  XP_001235955.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 9)
    --
    68(a)
    62(a)
    (see all 9)
    possible ortholog
    many ↔ many
    (see all 9)
    2(70550445-70589891)
    2(95106342-95120906)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL859497.22   -- 74.52(n)    AL859497.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb64b072 wufb64b07 75.98(n)   322529  BC059614.1 


    ENSEMBL Gene Tree for RDH16 (if available)
    TreeFam Gene Tree for RDH16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RDH16 gene
    SDR9C72  DHRS92  HSD11B22  HSD17B62  HSD17B22  BDH12  RDH82  DHRS7B2  
    DHRS72  HSD17B12  KDSR2  DHRS7C2  RDH52  
    8 SIMAP similar genes for RDH16 using alignment to 1 protein entry:     RDH16_HUMAN:
    HSD17B6    SDR9C7    RDHL    RDH5    DHRS9    BDH1
    HSD17B2    HSD11B2

    RDH16 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RDH16
    PGOHUM00000239480 PGOHUM00000239481 PGOHUM00000239810


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/214 SNPs in RDH16 are shown (see all 214)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916058761,2
    C--57344735(+) AAGGTA/C/GCCTGC 1 -- int10--------
    rs1848531981,2
    --57344860(+) CCAGCA/GGCTTG 1 -- int10--------
    rs1451182801,2
    --57344927(+) CCCCAC/TTGGGA 1 -- int10--------
    rs1897324921,2
    --57344992(+) CACTCC/TTTTCT 1 -- int10--------
    rs1178417411,2
    F--57345105(+) TTGCAA/CTCTCA 1 -- int11Minor allele frequency- C:0.03EA 120
    rs1930511771,2
    --57345316(+) GCCTAA/TGGGGC 1 -- ut310--------
    rs1150264601,2
    C,F--57345323(+) GGGCCG/ACATAA 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs1404594341,2
    --57345349(+) CACCAC/TGTGTA 1 -- ut310--------
    rs794524791,2
    C,F--57345407(+) CACCCC/TGTGGG 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs10557091,2
    C--57345514(-) GCTAAC/AAACTG 1 -- ut31 ese33Minor allele frequency- A:0.00MN NA 188

    HapMap Linkage Disequilibrium report for RDH16 (57345215 - 57353158 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RDH16:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv436148CNV Deletion17901297
    nsv516039CNV Loss19592680
    nsv512276CNV Loss21212237
    dgv1427n71CNV Gain21882294
    nsv832428CNV Gain17160897
    esv24053CNV Gain+Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for RDH16:    About MalaCards
    cytochrome p450    tuberculosis    alcoholism


    RDH16 for disorders           About GeneDecksing


    Export disorders for RDH16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RDH16 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RDH16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and characterization of a new human microsomal NAD+- dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha- hydroxysteroids. (PubMed id 9677409)1, 2, 3, 9 Gough W.H.... Kedishvili N.Y. (1998)
    2. Cloning and characterization of retinol dehydrogenase transcripts expressed in human epidermal keratinocytes. (PubMed id 10329026)1, 2, 3 Jurukovski V....Simon M. (1999)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    4. Differential recognition of the free versus bound retinol by human microsomal retinol/sterol dehydrogenases: characterization of the holo-CRBP dehydrogenase activity of RoDH-4. (PubMed id 12534290)1, 2 Lapshina E.A.... Kedishvili N.Y. (2003)
    5. Expression of a retinol dehydrogenase (hRoDH-4), a member of the retinol/steroid dehydrogenase family implicated in retinoic acid biosynthesis, in normal and neoplastic endometria. (PubMed id 11967490)1, 2 Cain J.M.... Weisz J. (2002)
    6. 13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands? (PubMed id 12646198)6 Karlsson T....TAPrmAo H. (2003)
    7. Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties. (PubMed id 11294878)1 Chetyrkin S.V....Kedishvili N.Y. (2001)
    8. Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenase. (PubMed id 18502750)9 Belyaeva O.V....Kedishvili N.Y. (2008)
    9. Both all-trans retinoic acid and cytochrome P450 (CYP 26) inhibitors affect the expression of vitamin A metabolizing enzymes and reti noid biomarkers in organotypic epidermis. (PubMed id 19294396)9 Pavez LoriA" E....TAPrmAo H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8608 HGNC: 29674 AceView: RODH-4 Ensembl:ENSG00000139547 euGenes: HUgn8608
    ECgene: RDH16 Kegg: 8608 H-InvDB: RDH16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RDH16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RDH16 gene:
    Search GeneIP for patents involving RDH16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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