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Aliases for RDH14 Gene

Aliases for RDH14 Gene

  • Retinol Dehydrogenase 14 (All-Trans/9-Cis/11-Cis) 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 7C Member 4 3 4
  • Retinol Dehydrogenase 14 (All-Trans And 9-Cis) 2 3
  • Alcohol Dehydrogenase PAN2 3 4
  • SDR7C4 3 4
  • PAN2 3 4
  • Short Chain Dehydrogenase/Reductase Family 7C, Member 4 3
  • Short Chain Dehydrogenase/Reductase Family 7C 2
  • Pancreas Protein 2 3
  • EC 1.1.1.- 4
  • Member 4 2

External Ids for RDH14 Gene

Previous GeneCards Identifiers for RDH14 Gene

  • GC02M018670
  • GC02M018703
  • GC02M018720
  • GC02M018658
  • GC02M018659
  • GC02M018600
  • GC02M018601
  • GC02M018735

Summaries for RDH14 Gene

GeneCards Summary for RDH14 Gene

RDH14 (Retinol Dehydrogenase 14 (All-Trans/9-Cis/11-Cis)) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is RDH12.

UniProtKB/Swiss-Prot for RDH14 Gene

  • Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.

Gene Wiki entry for RDH14 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RDH14 Gene

Genomics for RDH14 Gene

Regulatory Elements for RDH14 Gene

Promoters for RDH14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RDH14 on UCSC Golden Path with GeneCards custom track

Genomic Location for RDH14 Gene

Chromosome:
2
Start:
18,554,723 bp from pter
End:
18,560,693 bp from pter
Size:
5,971 bases
Orientation:
Minus strand

Genomic View for RDH14 Gene

Genes around RDH14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RDH14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RDH14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RDH14 Gene

Proteins for RDH14 Gene

  • Protein details for RDH14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBH5-RDH14_HUMAN
    Recommended name:
    Retinol dehydrogenase 14
    Protein Accession:
    Q9HBH5

    Protein attributes for RDH14 Gene

    Size:
    336 amino acids
    Molecular mass:
    36865 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RDH14 Gene

Proteomics data for RDH14 Gene at MOPED

Post-translational modifications for RDH14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RDH14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RDH14 Gene

Domains & Families for RDH14 Gene

Gene Families for RDH14 Gene

Suggested Antigen Peptide Sequences for RDH14 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBH5

UniProtKB/Swiss-Prot:

RDH14_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with RDH14: view

Function for RDH14 Gene

Molecular function for RDH14 Gene

UniProtKB/Swiss-Prot Function:
Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.

Enzyme Numbers (IUBMB) for RDH14 Gene

genes like me logo Genes that share phenotypes with RDH14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RDH14

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RDH14 Gene

Localization for RDH14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RDH14 Gene COMPARTMENTS Subcellular localization image for RDH14 gene
Compartment Confidence
lysosome 5
nucleus 5
vacuole 5
endoplasmic reticulum 4
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RDH14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 16210410
genes like me logo Genes that share ontologies with RDH14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RDH14 Gene

Pathways & Interactions for RDH14 Gene

genes like me logo Genes that share pathways with RDH14: view

Pathways by source for RDH14 Gene

1 GeneGo (Thomson Reuters) pathway for RDH14 Gene

Interacting Proteins for RDH14 Gene

Gene Ontology (GO) - Biological Process for RDH14 Gene

None

No data available for SIGNOR curated interactions for RDH14 Gene

Drugs & Compounds for RDH14 Gene

(1) Drugs for RDH14 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved Nutra Target 413

(1) Additional Compounds for RDH14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with RDH14: view

Transcripts for RDH14 Gene

mRNA/cDNA for RDH14 Gene

Unigene Clusters for RDH14 Gene

Retinol dehydrogenase 14 (all-trans/9-cis/11-cis):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RDH14 Gene

No ASD Table

Relevant External Links for RDH14 Gene

GeneLoc Exon Structure for
RDH14
ECgene alternative splicing isoforms for
RDH14

Expression for RDH14 Gene

mRNA expression in normal human tissues for RDH14 Gene

Protein differential expression in normal tissues from HIPED for RDH14 Gene

This gene is overexpressed in Nasal epithelium (53.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RDH14 Gene



SOURCE GeneReport for Unigene cluster for RDH14 Gene Hs.120319

mRNA Expression by UniProt/SwissProt for RDH14 Gene

Q9HBH5-RDH14_HUMAN
Tissue specificity: Expressed in brain, kidney, pancreas and placenta.
genes like me logo Genes that share expression patterns with RDH14: view

Protein tissue co-expression partners for RDH14 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RDH14 Gene

Orthologs for RDH14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RDH14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RDH14 35
  • 99.8 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RDH14 35
  • 86.81 (n)
  • 89.29 (a)
RDH14 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RDH14 36
  • 80 (a)
OneToOne
RDH14 35
  • 91.67 (n)
  • 93.75 (a)
mouse
(Mus musculus)
Mammalia Rdh14 16
Rdh14 36
  • 90 (a)
OneToOne
Rdh14 35
  • 86.08 (n)
  • 90.82 (a)
oppossum
(Monodelphis domestica)
Mammalia RDH14 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RDH14 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rdh14 35
  • 85.13 (n)
  • 90.51 (a)
chicken
(Gallus gallus)
Aves RDH14 35
  • 72.84 (n)
  • 78.65 (a)
RDH14 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RDH14 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rdh14 35
  • 73.62 (n)
  • 79.14 (a)
zebrafish
(Danio rerio)
Actinopterygii rdh14a 36
  • 72 (a)
OneToMany
rdh14b 36
  • 67 (a)
OneToMany
Dr.16840 35
fruit fly
(Drosophila melanogaster)
Insecta CG3842 35
  • 50.89 (n)
  • 51.01 (a)
CG7675 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dhs-24 36
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV9 36
  • 25 (a)
OneToMany
-- 38
bread mold
(Neurospora crassa)
Ascomycetes NCU09278 35
  • 47.08 (n)
  • 39.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
Species with no ortholog for RDH14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RDH14 Gene

ENSEMBL:
Gene Tree for RDH14 (if available)
TreeFam:
Gene Tree for RDH14 (if available)

Paralogs for RDH14 Gene

Paralogs for RDH14 Gene

(7) SIMAP similar genes for RDH14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RDH14: view

Variants for RDH14 Gene

Structural Variations from Database of Genomic Variants (DGV) for RDH14 Gene

Variant ID Type Subtype PubMed ID
esv2751837 CNV Gain 17911159
nsv2624 CNV Insertion 18451855

Variation tolerance for RDH14 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RDH14 Gene

HapMap Linkage Disequilibrium report
RDH14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RDH14 Gene

Disorders for RDH14 Gene

Relevant External Links for RDH14

Genetic Association Database (GAD)
RDH14
Human Genome Epidemiology (HuGE) Navigator
RDH14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RDH14

No disorders were found for RDH14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RDH14 Gene

Publications for RDH14 Gene

  1. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. (PMID: 12226107) Haeseleer F. … Palczewski K. (J. Biol. Chem. 2002) 2 3 4 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues. (PMID: 12435598) Belyaeva O.V. … Kedishvili N.Y. (FEBS Lett. 2002) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3

Products for RDH14 Gene

Sources for RDH14 Gene

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