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Aliases for RDH13 Gene

Aliases for RDH13 Gene

  • Retinol Dehydrogenase 13 (All-Trans/9-Cis) 2 3
  • Short Chain Dehydrogenase/Reductase Family 7C Member 3 3 4
  • Retinol Dehydrogenase 13 (All-Trans And 9-Cis) 2 3
  • SDR7C3 3 4
  • Short Chain Dehydrogenase/Reductase Family 7C, Member 3 3
  • Short Chain Dehydrogenase/Reductase Family 7C 2
  • Retinol Dehydrogenase 13 3
  • EC 1.1.1.- 4
  • Member 3 2

External Ids for RDH13 Gene

Previous GeneCards Identifiers for RDH13 Gene

  • GC19M055979
  • GC19M060231
  • GC19M060247
  • GC19M055556
  • GC19M051879

Summaries for RDH13 Gene

Entrez Gene Summary for RDH13 Gene

  • This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

GeneCards Summary for RDH13 Gene

RDH13 (Retinol Dehydrogenase 13 (All-Trans/9-Cis)) is a Protein Coding gene. Among its related pathways are Visual Cycle in Retinal Rods. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is DHRS12.

UniProtKB/Swiss-Prot for RDH13 Gene

  • Does not exhibit retinol dehydrogenase (RDH) activity in vitro

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RDH13 Gene

Genomics for RDH13 Gene

Regulatory Elements for RDH13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RDH13 Gene

55,039,108 bp from pter
55,071,291 bp from pter
32,184 bases
Minus strand

Genomic View for RDH13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RDH13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RDH13 Gene

Proteins for RDH13 Gene

  • Protein details for RDH13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinol dehydrogenase 13
    Protein Accession:
    Secondary Accessions:
    • Q6UX79
    • Q96G88

    Protein attributes for RDH13 Gene

    331 amino acids
    Molecular mass:
    35932 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RDH13 Gene


neXtProt entry for RDH13 Gene

Proteomics data for RDH13 Gene at MOPED

Post-translational modifications for RDH13 Gene

  • Ubiquitination at Lys102
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RDH13 Gene

Domains for RDH13 Gene

Gene Families for RDH13 Gene

Suggested Antigen Peptide Sequences for RDH13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with RDH13: view

Function for RDH13 Gene

Molecular function for RDH13 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit retinol dehydrogenase (RDH) activity in vitro

Enzyme Numbers (IUBMB) for RDH13 Gene

Gene Ontology (GO) - Molecular Function for RDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0016491 oxidoreductase activity IEA --
GO:0050662 coenzyme binding --
genes like me logo Genes that share ontologies with RDH13: view
genes like me logo Genes that share phenotypes with RDH13: view

Animal Models for RDH13 Gene

MGI Knock Outs for RDH13:

Animal Model Products

miRNA for RDH13 Gene

miRTarBase miRNAs that target RDH13

No data available for Transcription Factor Targeting and HOMER Transcription for RDH13 Gene

Localization for RDH13 Gene

Subcellular locations from

Jensen Localization Image for RDH13 Gene COMPARTMENTS Subcellular localization image for RDH13 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with RDH13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RDH13 Gene

Pathways for RDH13 Gene

SuperPathways for RDH13 Gene

genes like me logo Genes that share pathways with RDH13: view

Pathways by source for RDH13 Gene

1 Qiagen pathway for RDH13 Gene

Interacting Proteins for RDH13 Gene

Gene Ontology (GO) - Biological Process for RDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0009644 response to high light intensity IEA --
GO:0010842 retina layer formation IEA --
GO:0042462 eye photoreceptor cell development IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with RDH13: view

Compounds for RDH13 Gene

(1) Drugbank Compounds for RDH13 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Vitamin A
  • (2e,4e,6e,8e)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol
68-26-8 Target approved, nutraceutical

(8) HMDB Compounds for RDH13 Gene

Compound Synonyms Cas Number PubMed IDs
  • 13-KODE
Not Available
  • 1-Butanol
  • 3alpha,7alpha,12alpha,24zeta-Tetrahydroxy-5beta-cholestanoyl-CoA
Not Available
  • 3a,7a,12a-Trihydroxy-5b-24-oxocholestanoyl-CoA
Not Available
  • 3a,7a,12a-Trihydroxy-5b-cholestan-26-oyl-CoA
genes like me logo Genes that share compounds with RDH13: view

Transcripts for RDH13 Gene

Unigene Clusters for RDH13 Gene

Retinol dehydrogenase 13 (all-trans/9-cis):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RDH13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RDH13 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - - - - - -
SP7: -
SP8: -

Relevant External Links for RDH13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RDH13 Gene

mRNA expression in normal human tissues for RDH13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RDH13 Gene

This gene is overexpressed in Nasal epithelium (10.4), Bone (7.7), and Placenta (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RDH13 Gene

SOURCE GeneReport for Unigene cluster for RDH13 Gene Hs.327631

mRNA Expression by UniProt/SwissProt for RDH13 Gene

Tissue specificity: Expressed mostly in eye, pancreas, placenta and lung. In the retina, detected in the inner segment of the photoreceptor cells. Weak signals were observed in a small population of inner nuclear neurons and the inner plexiform layer.
genes like me logo Genes that share expressions with RDH13: view

Expression partners for RDH13 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RDH13 Gene

Orthologs for RDH13 Gene

This gene was present in the common ancestor of animals.

Orthologs for RDH13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RDH13 35
  • 87.01 (n)
  • 86.4 (a)
RDH13 36
  • 85 (a)
(Canis familiaris)
Mammalia RDH13 35
  • 87.31 (n)
  • 89.12 (a)
RDH13 36
  • 88 (a)
(Mus musculus)
Mammalia Rdh13 35
  • 84.01 (n)
  • 86.52 (a)
Rdh13 16
Rdh13 36
  • 84 (a)
(Pan troglodytes)
Mammalia RDH13 35
  • 99.4 (n)
  • 99.7 (a)
RDH13 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rdh13 35
  • 84.27 (n)
  • 86.56 (a)
(Ornithorhynchus anatinus)
Mammalia RDH13 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rdh13 35
  • 66.35 (n)
  • 74.38 (a)
(Danio rerio)
Actinopterygii sbcb464 35
si:dkey-23o4.6 35
  • 57.1 (n)
  • 54.19 (a)
rdh12l 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005980 35
  • 58.33 (n)
  • 54.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30491 35
  • 55.8 (n)
  • 52.4 (a)
CG2064 36
  • 52 (a)
CG2065 36
  • 51 (a)
CG2070 36
  • 51 (a)
CG30491 36
  • 50 (a)
CG30495 36
  • 45 (a)
CG3842 36
  • 37 (a)
Species with no ortholog for RDH13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RDH13 Gene

Gene Tree for RDH13 (if available)
Gene Tree for RDH13 (if available)

Paralogs for RDH13 Gene

Paralogs for RDH13 Gene

(9) SIMAP similar genes for RDH13 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RDH13: view

Variants for RDH13 Gene

Sequence variations from dbSNP and Humsavar for RDH13 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1189 -- 55,044,786(-) GGCTC(C/T)GTGCA utr-variant-3-prime, nc-transcript-variant
rs4029 -- 55,044,477(+) AACTC(A/G)GGATG utr-variant-3-prime, nc-transcript-variant
rs10666 -- 55,044,891(+) AGCCC(A/G)GGGCA utr-variant-3-prime, nc-transcript-variant
rs13322 -- 55,045,311(+) GGCCC(A/G)AGTGT splice-acceptor-variant
rs754235 -- 55,046,865(-) CGCCC(A/G)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RDH13 Gene

Variant ID Type Subtype PubMed ID
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
nsv833880 CNV Loss 17160897
dgv4014n71 CNV Loss 21882294
nsv912446 CNV Loss 21882294
nsv912448 CNV Loss 21882294
dgv1131e1 CNV Complex 17122850
esv34356 CNV Gain 17911159
nsv9770 CNV Loss 18304495
esv2671441 CNV Deletion 23128226
esv9070 CNV Loss 19470904
esv2718944 CNV Deletion 23290073
esv2672890 CNV Deletion 23128226
nsv817874 CNV Loss 17921354

Relevant External Links for RDH13 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RDH13 Gene

Disorders for RDH13 Gene

Relevant External Links for RDH13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RDH13 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RDH13 Gene

Publications for RDH13 Gene

  1. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. (PMID: 12226107) Haeseleer F. … Palczewski K. (J. Biol. Chem. 2002) 2 3 4
  2. Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity. (PMID: 18039331) Belyaeva O.V. … Kedishvili N.Y. (FEBS J. 2008) 3 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4

Products for RDH13 Gene

Sources for RDH13 Gene

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