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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RDH11 Gene

protein-coding   GIFtS: 63
GCID: GC14M068143

Retinol Dehydrogenase 11 (All-Trans/9-Cis/11-Cis)

(Previous name: retinol dehydrogenase 11 (all-trans and 9-cis))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Retinol Dehydrogenase 11 (All-Trans/9-Cis/11-Cis)1 2     CGI822
Androgen-Regulated Short-Chain Dehydrogenase/Reductase 11 2 3     HCBP122
PSDR12 3 5     MDT12
Prostate Short-Chain Dehydrogenase/Reductase 12 3     SCALD2
Retinal Reductase 12 3     SDR7C12
ARSDR12 3     Prostate Short-Chain Dehydrogenase Reductase 12
HCV Core-Binding Protein HCBP122 3     Retinol Dehydrogenase 112
RALR12 5     Short Chain Dehydrogenase/Reductase Family 7C, Member 12
Member 11     EC 1.1.1.3003
Retinol Dehydrogenase 11 (All-Trans And 9-Cis)1     RalR13
Short Chain Dehydrogenase/Reductase Family 7C1     

External Ids:    HGNC: 179641   Entrez Gene: 511092   Ensembl: ENSG000000720427   OMIM: 6078495   UniProtKB: Q8TC123   

Export aliases for RDH11 gene to outside databases

Previous GC identifers: GC14M061937 GC14M066133 GC14M067213 GC14M048313


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RDH11 Gene:
The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain
dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. (provided by RefSeq, Nov
2011)

GeneCards Summary for RDH11 Gene: 
RDH11 (retinol dehydrogenase 11 (all-trans/9-cis/11-cis)) is a protein-coding gene. Diseases associated with RDH11 include epiglottitis, and retinitis, and among its related super-pathways are the visual cycle I (vertebrates) and Visual phototransduction. GO annotations related to this gene include NADP-retinol dehydrogenase activity and nucleotide binding. An important paralog of this gene is ENSG00000258466.

UniProtKB/Swiss-Prot: RDH11_HUMAN, Q8TC12
Function: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent
retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of
short-chain aldehydes. No steroid dehydrogenase activity detected

Gene Wiki entry for RDH11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RDH11 gene promoter:
         MyoD   NF-AT   Arnt   AREB6   NF-AT4   NF-AT2   STAT3   c-Myb   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRDH11 promoter sequence
   Search SABiosciences Chromatin IP Primers for RDH11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RDH11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q24.1

RDH11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RDH11 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M068143:  view genomic region     (about GC identifiers)

Start:
68,143,517 bp from pter      End:
68,162,531 bp from pter
Size:
19,015 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RDH11_HUMAN, Q8TC12 (See protein sequence)
Recommended Name: Retinol dehydrogenase 11  
Size: 318 amino acids; 35386 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein
Secondary accessions: A6NDK3 A8K062 B2RB26 B4DDW0 Q6IAH5 Q9NRW0 Q9Y391
Alternative splicing: 3 isoforms:  Q8TC12-1   Q8TC12-2   Q8TC12-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RDH11: NX_Q8TC12

Explore proteomics data for RDH11 at MOPED 

Post-translational modifications:

  • UniProtKB: Not glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TC12

  • RDH11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RDH11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001239579.1  NP_057110.3  

    ENSEMBL proteins: 
     ENSP00000370750   ENSP00000452079   ENSP00000416395   ENSP00000451280   ENSP00000450802  
     ENSP00000450651   ENSP00000450435   ENSP00000452108  
    Reactome Protein details: Q8TC12
    Human Recombinant Protein Products for RDH11: 
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    Cloud-Clone Corp. Proteins for RDH11 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001917photoreceptor inner segment ----
    GO:0005622intracellular ISS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--

    RDH11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SDRC2: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 2

    3 InterPro protein domains:
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8TC12

    ProtoNet protein and cluster: Q8TC12

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: RDH11_HUMAN, Q8TC12
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    RDH11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RDH11_HUMAN, Q8TC12
    Function: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent
    retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of
    short-chain aldehydes. No steroid dehydrogenase activity detected
    Catalytic activity: All-trans-retinol + NADP(+) = all-trans-retinal + NADPH
    Biophysicochemical properties: Kinetic parameters: KM=0.23 uM for NADPH; KM=0.8 uM for NADP; KM=0.5 uM for
    all-trans-retinal; KM=0.62 uM for 13-cis-retinal; KM=0.19 uM for 9-cis-retinal; KM=1.3 uM for all-trans-retinol;
    Vmax=18 nmol/min/mg enzyme with all-trans-retinal as substrate; Vmax=7 nmol/min/mg enzyme with 13-cis-retinal as
    substrate; Vmax=1.6 nmol/min/mg enzyme with 9-cis-retinal as substrate; Vmax=0.95 nmol/min/mg enzyme with
    all-trans-retinol as substrate; Note=Vmax is measured per mg microsomal protein;
    Induction: By androgens in prostate cancer cells

         Enzyme Number (IUBMB): EC 1.1.1.3001

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004745retinol dehydrogenase activity ISS--
    GO:0016491oxidoreductase activity ----
    GO:0050662coenzyme binding ----
    GO:0052650NADP-retinol dehydrogenase activity IDA12807874
         
    RDH11 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rdh11):
     reproductive system  vision/eye 

    RDH11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RDH11: Rdh11tm1Tsyk Rdh11tm1Akjc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RDH11 
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    SwitchGear 3'UTR luciferase reporter plasmidRDH11 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RDH11 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1the visual cycle I (vertebrates)
    the visual cycle I (vertebrates)0.52
    The canonical retinoid cycle in rods (twilight vision)0.50
    retinol biosynthesis0.52
    2Visual phototransduction
    Visual phototransduction0.48
    Diseases associated with visual transduction0.47
    Retinoid metabolism and transport0.48
    3Retinol metabolism
    Retinol metabolism0.95
    4Signaling by GPCR
    Signal Transduction0.55
    5Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RDH11
        Retinol metabolism


    1 GeneGo (Thomson Reuters) Pathway for RDH11
        Retinol metabolism

    2 BioSystems Pathways for RDH11
        retinol biosynthesis
    the visual cycle I (vertebrates)


    5/6        Reactome Pathways for RDH11 (see all 6)
        Diseases associated with visual transduction
    Retinoid metabolism and transport
    Signal Transduction
    The canonical retinoid cycle in rods (twilight vision)
    Visual phototransduction


    2         Kegg Pathways  (Kegg details for RDH11):
        Retinol metabolism
    Metabolic pathways


    RDH11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RDH11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/18 Interacting proteins for RDH11 (Q8TC122, 3 ENSP000003707504) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CA12O435702, 3, ENSP000001786384MINT-8268603 I2D: score=2 STRING: ENSP00000178638
    BLOC1S2Q6QNY12, 3MINT-8268592 I2D: score=2 
    ROBO2Q9HCK42, 3, ENSP000004171644MINT-8268625 I2D: score=2 STRING: ENSP00000417164
    GRB2P629933I2D: score=2 
    DDA1Q9BW613I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0007603phototransduction, visible light TAS--
    GO:0008152metabolic process ----
    GO:0016062adaptation of rhodopsin mediated signaling ----
    GO:0042572retinol metabolic process ISS--

    RDH11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RDH11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RDH11

    1 HMDB Compound for RDH11    About this table
    CompoundSynonyms CAS #PubMed Ids
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    1 DrugBank Compound for RDH11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin A[11,12-3H]-Retinol (see all 18)68-26-8target--16787387

    2 Novoseek inferred chemical compound relationships for RDH11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin a 71.4 5 14674758 (1), 12807874 (1), 16787387 (1)
    nadph 52.3 2 18039331 (1), 12036956 (1)

    Search CenterWatch for drugs/clinical trials and news about RDH11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RDH11 gene (2 alternative transcripts): 
    NM_001252650.1  NM_016026.3  

    Unigene Cluster for RDH11:

    Retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
    Hs.719925  [show with all ESTs]
    Unigene Representative Sequence: AB209223
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381346(uc001xjv.4 uc001xjx.4 uc001xjw.4) ENST00000553384
    ENST00000553578 ENST00000428130 ENST00000554731 ENST00000554035 ENST00000553816
    ENST00000557273 ENST00000557726 ENST00000557331 ENST00000556692
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    Additional mRNA sequence: 

    AB209223.1 AF151840.1 AF167438.1 AF395068.1 AK001494.1 AK057195.1 AK074749.1 AK289427.1 
    AK293355.1 AK307500.1 AK314465.1 AL096716.1 BC000112.1 BC011727.2 BC026274.1 BC037302.1 
    BC051291.1 CR457180.1 DQ426886.1 

    24/39 DOTS entries (see all 39):

    DT.91960564  DT.414230  DT.92426971  DT.100765475  DT.100860746  DT.97816947  DT.87017583  DT.75131103 
    DT.91866886  DT.95167332  DT.99948819  DT.95167336  DT.100858811  DT.120767759  DT.97864689  DT.91766449 
    DT.100676765  DT.100829383  DT.100836137  DT.120767772  DT.92343222  DT.95310460  DT.100841328  DT.101984917 

    24/1100 AceView cDNA sequences (see all 1100):

    BQ882554 BC051291 AI950046 CR602441 BU737469 BI522866 AI984330 AI358215 
    BM679606 BF222055 CR608390 AI174674 BX447394 BQ720728 BU625192 BQ049233 
    BU183171 CR610010 BM689533 BM802564 AI382141 AI394027 BQ065032 BM980632 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for RDH11 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a ·
    SP1:                                                              -                             -           -                                   -     -         
    SP2:                                                  -     -     -                             -           -                                   -     -         
    SP3:                                                        -     -     -                       -           -                                   -     -         
    SP4:                                                              -                             -     -     -                                   -     -         
    SP5:                                                              -                             -     -     -                                                   

    ExUns: 9b · 9c · 9d · 9e · 9f · 9g
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RDH11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RDH11 expression in normal human tissues (normalized intensities)      RDH11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAGCAGGG
    RDH11 Expression
    About this image


    RDH11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Umbilical Cord (Extraembryonic Tissues)
             cord blood   
     
     Blood (Extraembryonic Tissues)
             cord blood   
     
     Prostate (Endocrine System)

    See RDH11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RDH11

    SOURCE GeneReport for Unigene cluster: Hs.719925

    UniProtKB/Swiss-Prot: RDH11_HUMAN, Q8TC12
    Tissue specificity: Predominantly expressed in the epithelial cells of prostate, in both basal and luminal
    secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon,
    peripherical blood leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular
    stromal cells, endothelial cells, or infiltrating lymphocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RDH11 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rdh111 , 5 retinol dehydrogenase 111, 5 82.74(n)1
    86.17(a)1
      12 (35.51 cM)5
    172521  NM_021557.51  NP_067532.21 
     791743375 
    chicken
    (Gallus gallus)
    Aves --
    --
    63(a)
    1 → many
    5(28165238-28170987)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    66(a)
    65(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343272.1(1049956-1102885)
    GL343272.1(1032418-1064517)
    zebrafish
    (Danio rerio)
    Actinopterygii rdh126
    si:dkey-94e7.26
    (see all 8)
    si:dkey-94e7.2
    (see all 8)
    62(a)
    54(a)
    (see all 8)
    1 ↔ many
    possible ortholog
    (see all 8)
    13(33279150-33289445)
    2(30435902-30441252)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG20656
    CG20706
    (see all 7)
    --
    50(a)
    47(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    2R(3551292-3552774)
    2R(3549487-3550764)
    rice
    (Oryza sativa)
    Liliopsida Os11g01818001 hypothetical protein 48.75(n)
    44.09(a)
      4349945  NM_001072434.1  NP_001065902.1 


    ENSEMBL Gene Tree for RDH11 (if available)
    TreeFam Gene Tree for RDH11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RDH11 gene
    ENSG000002584662  DHRS122  WWOX2  DHRSX2  RDH122  DHRS132  RDH142  RDH132  
    9 SIMAP similar genes for RDH11 using alignment to 8 protein entries:     RDH11_HUMAN (see all proteins):
    RDH12    NT5C1B-RDH14    RDH13    RDH14    DHRSX    DHRS13
    DHRS12    WWOX    HSD17B7

    RDH11 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RDH11
    PGOHUM00000240096


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/440 SNPs in RDH11 are shown (see all 440)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs771736421,2
    C--68143866(+) GGGAAA/CACTAC 2 -- ut310--------
    rs1995666971,2
    C--68143910(+) TTGAT-/AAGAAGTC 2 -- cds10--------
    rs1457809401,2
    C--68144060(+) TTTTT-/TTTG  
            
    TTTGT
    2 -- ut310--------
    rs1995320981,2
    C--68144063(+) TTTTTG/TTTTGT 2 -- ut310--------
    rs10592381,2
    C,F,A,H--68144191(-) AAAGAT/CATTAA 2 -- ut3122Minor allele frequency- C:0.18MN NA NS EA CSA WA 2668
    rs1863803691,2
    --68144322(+) ATGTGC/GTCTTG 2 -- ut310--------
    rs77651,2
    C,F,H--68144329(-) TACCCA/GCCAAG 2 -- ut31 ese317Minor allele frequency- G:0.11MN NA NS EA CSA WA 1816
    rs74101,2
    C,F,A,H--68144423(+) GATTAT/CTGTGG 2 -- ut31 ese318Minor allele frequency- C:0.07MN NA NS EA 1891
    rs1500568451,2
    C--68144430(+) TGGCT-/GGGTTTT 2 -- ut310--------
    rs748485741,2
    C,F--68144585(+) AGCCCT/CGCTCC 2 -- ut311Minor allele frequency- C:0.07EA 120

    HapMap Linkage Disequilibrium report for RDH11 (68143517 - 68162531 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RDH11:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv521832CNV Loss19592680
    nsv902068CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607849    OMIM disorders: --

    12 diseases for RDH11:    About MalaCards
    epiglottitis    retinitis    toxic shock syndrome    prostatitis
    respiratory failure    muscular atrophy    hepatitis c    tuberculosis
    hepatocellular carcinoma    hepatitis    prostate cancer    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for RDH11:
    Epiglottitis

    RDH11 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RDH11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 14674758 (1)


    Export disorders for RDH11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RDH11 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with RDH11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium. (PubMed id 11245473)1, 2, 9 Lin B.... Nelson P.S. (2001)
    2. Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1). (PubMed id 12036956)1, 2, 9 Kedishvili N.Y.... Nelson P.S. (2002)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. (PubMed id 12226107)1, 3 Haeseleer F.... Palczewski K. (2002)
    8. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    9. Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line. (PubMed id 8018917)1, 3 Hara T....Miyajima A. (1994)
    10. Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins. (PubMed id 12807874)1, 9 Kasus-Jacobi A....Brown M.S. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51109 HGNC: 17964 AceView: VTI1B Ensembl:ENSG00000072042 euGenes: HUgn51109
    ECgene: RDH11 Kegg: 51109 H-InvDB: RDH11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RDH11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RDH11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RDH11 gene:
    Search GeneIP for patents involving RDH11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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