Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RDH11 Gene

Aliases for RDH11 Gene

  • Retinol Dehydrogenase 11 (All-Trans/9-Cis/11-Cis) 2 3 5
  • Androgen-Regulated Short-Chain Dehydrogenase/Reductase 1 2 3 4
  • HCV Core-Binding Protein HCBP12 3 4
  • Retinal Reductase 1 3 4
  • ARSDR1 3 4
  • SDR7C1 3 4
  • RALR1 3 4
  • PSDR1 3 4
  • Short Chain Dehydrogenase/Reductase Family 7C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 7C Member 1 4
  • Retinol Dehydrogenase 11 (All-Trans And 9-Cis) 2
  • Prostate Short-Chain Dehydrogenase Reductase 1 3
  • Prostate Short-Chain Dehydrogenase/Reductase 1 4
  • Short Chain Dehydrogenase/Reductase Family 7C 2
  • EC 1.1.1.300 4
  • Member 1 2
  • HCBP12 3
  • RDJCSS 3
  • CGI82 3
  • SCALD 3
  • MDT1 3

External Ids for RDH11 Gene

Previous GeneCards Identifiers for RDH11 Gene

  • GC14M061937
  • GC14M066133
  • GC14M067213
  • GC14M068143
  • GC14M048313

Summaries for RDH11 Gene

Entrez Gene Summary for RDH11 Gene

  • The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. [provided by RefSeq, Nov 2011]

GeneCards Summary for RDH11 Gene

RDH11 (Retinol Dehydrogenase 11 (All-Trans/9-Cis/11-Cis)) is a Protein Coding gene. Diseases associated with RDH11 include retinal dystrophy, juvenile cataracts, and short stature syndrome and retinitis pigmentosa-juvenile cataract-short stature-intellectual disability syndrome. Among its related pathways are Metabolism and Metabolism of xenobiotics by cytochrome P450. GO annotations related to this gene include oxidoreductase activity and retinol dehydrogenase activity. An important paralog of this gene is RDH14.

UniProtKB/Swiss-Prot for RDH11 Gene

  • Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected.

Gene Wiki entry for RDH11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RDH11 Gene

Genomics for RDH11 Gene

Regulatory Elements for RDH11 Gene

Enhancers for RDH11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RDH11 on UCSC Golden Path with GeneCards custom track

Promoters for RDH11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RDH11 on UCSC Golden Path with GeneCards custom track

Genomic Location for RDH11 Gene

Chromosome:
14
Start:
67,676,800 bp from pter
End:
67,695,814 bp from pter
Size:
19,015 bases
Orientation:
Minus strand

Genomic View for RDH11 Gene

Genes around RDH11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RDH11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RDH11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RDH11 Gene

Proteins for RDH11 Gene

  • Protein details for RDH11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC12-RDH11_HUMAN
    Recommended name:
    Retinol dehydrogenase 11
    Protein Accession:
    Q8TC12
    Secondary Accessions:
    • A6NDK3
    • A8K062
    • B2RB26
    • B4DDW0
    • Q0QD40
    • Q6IAH5
    • Q9NRW0
    • Q9Y391

    Protein attributes for RDH11 Gene

    Size:
    318 amino acids
    Molecular mass:
    35386 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RDH11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RDH11 Gene

Proteomics data for RDH11 Gene at MOPED

Post-translational modifications for RDH11 Gene

No data available for DME Specific Peptides for RDH11 Gene

Domains & Families for RDH11 Gene

Gene Families for RDH11 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TC12

UniProtKB/Swiss-Prot:

RDH11_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with RDH11: view

Function for RDH11 Gene

Molecular function for RDH11 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.23 uM for NADPH {ECO:0000269 PubMed:12036956}; KM=0.8 uM for NADP {ECO:0000269 PubMed:12036956}; KM=0.5 uM for all-trans-retinal {ECO:0000269 PubMed:12036956}; KM=0.62 uM for 13-cis-retinal {ECO:0000269 PubMed:12036956}; KM=0.19 uM for 9-cis-retinal {ECO:0000269 PubMed:12036956}; KM=1.3 uM for all-trans-retinol {ECO:0000269 PubMed:12036956}; Vmax=18 nmol/min/mg enzyme with all-trans-retinal as substrate {ECO:0000269 PubMed:12036956}; Vmax=7 nmol/min/mg enzyme with 13-cis-retinal as substrate {ECO:0000269 PubMed:12036956}; Vmax=1.6 nmol/min/mg enzyme with 9-cis-retinal as substrate {ECO:0000269 PubMed:12036956}; Vmax=0.95 nmol/min/mg enzyme with all-trans-retinol as substrate {ECO:0000269 PubMed:12036956}; Note=Vmax is measured per mg microsomal protein.;
UniProtKB/Swiss-Prot CatalyticActivity:
All-trans-retinol + NADP(+) = all-trans-retinal + NADPH.
UniProtKB/Swiss-Prot Function:
Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected.
UniProtKB/Swiss-Prot Induction:
By androgens in prostate cancer cells.

Enzyme Numbers (IUBMB) for RDH11 Gene

Gene Ontology (GO) - Molecular Function for RDH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004745 retinol dehydrogenase activity ISS,TAS --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with RDH11: view
genes like me logo Genes that share phenotypes with RDH11: view

Human Phenotype Ontology for RDH11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RDH11 Gene

MGI Knock Outs for RDH11:

Animal Model Products

miRNA for RDH11 Gene

miRTarBase miRNAs that target RDH11

No data available for Transcription Factor Targets and HOMER Transcription for RDH11 Gene

Localization for RDH11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RDH11 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RDH11 Gene COMPARTMENTS Subcellular localization image for RDH11 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytosol 2
plasma membrane 2
cytoskeleton 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RDH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001917 photoreceptor inner segment IEA --
genes like me logo Genes that share ontologies with RDH11: view

Pathways & Interactions for RDH11 Gene

genes like me logo Genes that share pathways with RDH11: view

Pathways by source for RDH11 Gene

1 GeneGo (Thomson Reuters) pathway for RDH11 Gene
1 Qiagen pathway for RDH11 Gene

Gene Ontology (GO) - Biological Process for RDH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0042574 retinal metabolic process IDA 12807874
genes like me logo Genes that share ontologies with RDH11: view

No data available for SIGNOR curated interactions for RDH11 Gene

Drugs & Compounds for RDH11 Gene

(1) Drugs for RDH11 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved Nutra Target 438

(3) Additional Compounds for RDH11 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
Retinal
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-Nonatetraenal
  • All-E-Retinal
  • All-epsilon-Retinal
  • All-trans-Retinal
  • All-trans-Retinaldehyde
116-31-4
genes like me logo Genes that share compounds with RDH11: view

Transcripts for RDH11 Gene

Unigene Clusters for RDH11 Gene

Retinol dehydrogenase 11 (all-trans/9-cis/11-cis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RDH11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - -
SP10: - -
SP11:
SP12: - - - - - - - - - - - - - - - - - -
SP13: -

ExUns: 9b · 9c · 9d · 9e · 9f · 9g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for RDH11 Gene

GeneLoc Exon Structure for
RDH11
ECgene alternative splicing isoforms for
RDH11

Expression for RDH11 Gene

mRNA expression in normal human tissues for RDH11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RDH11 Gene

This gene is overexpressed in Nasal epithelium (9.3), Bone (9.1), and Retina (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RDH11 Gene



SOURCE GeneReport for Unigene cluster for RDH11 Gene Hs.719925

mRNA Expression by UniProt/SwissProt for RDH11 Gene

Q8TC12-RDH11_HUMAN
Tissue specificity: Predominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes.
genes like me logo Genes that share expression patterns with RDH11: view

Protein tissue co-expression partners for RDH11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RDH11 Gene

Orthologs for RDH11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RDH11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RDH11 35
  • 87.15 (n)
  • 89.7 (a)
dog
(Canis familiaris)
Mammalia RDH11 35
  • 89.15 (n)
  • 91.03 (a)
mouse
(Mus musculus)
Mammalia Rdh11 35
  • 83.06 (n)
  • 86.38 (a)
Rdh11 16
Rdh11 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RDH11 35
  • 99.54 (n)
  • 100 (a)
RDH11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rdh11 35
  • 83.28 (n)
  • 84.05 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii rdh12 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG2065 35
  • 56.36 (n)
  • 55.64 (a)
CG2064 36
  • 46 (a)
ManyToMany
CG2065 36
  • 51 (a)
ManyToMany
CG2070 36
  • 48 (a)
ManyToMany
CG30491 36
  • 44 (a)
ManyToMany
CG30495 36
  • 44 (a)
ManyToMany
CG3842 36
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dhs-22 35
  • 44.6 (n)
  • 38.38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02540 35
  • 52.29 (n)
  • 43.49 (a)
rice
(Oryza sativa)
Liliopsida Os01g0151700 35
  • 50.6 (n)
  • 46.07 (a)
Species with no ortholog for RDH11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RDH11 Gene

ENSEMBL:
Gene Tree for RDH11 (if available)
TreeFam:
Gene Tree for RDH11 (if available)

Paralogs for RDH11 Gene

Paralogs for RDH11 Gene

Pseudogenes.org Pseudogenes for RDH11 Gene

genes like me logo Genes that share paralogs with RDH11: view

Variants for RDH11 Gene

Sequence variations from dbSNP and Humsavar for RDH11 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7410 -- 67,677,706(+) GATTA(C/T)TGTGG utr-variant-3-prime
rs7765 -- 67,677,612(-) TACCC(A/G)CCAAG utr-variant-3-prime
rs7142897 -- 67,687,188(+) TTCTC(A/G)CCTCT intron-variant
rs7147404 -- 67,687,256(+) TTAAC(A/C/G)GTTTC intron-variant
rs8006772 -- 67,681,598(+) CCTAC(A/G)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RDH11 Gene

Variant ID Type Subtype PubMed ID
nsv902068 CNV Gain 21882294
nsv521832 CNV Loss 19592680

Variation tolerance for RDH11 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RDH11 Gene

HapMap Linkage Disequilibrium report
RDH11
Human Gene Mutation Database (HGMD)
RDH11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RDH11 Gene

Disorders for RDH11 Gene

MalaCards: The human disease database

(8) MalaCards diseases for RDH11 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
retinal dystrophy, juvenile cataracts, and short stature syndrome
  • rdjcss
retinitis pigmentosa-juvenile cataract-short stature-intellectual disability syndrome
  • retinal dystrophy-juvenile cataract-short stature syndrome
ecthyma
tinea favosa
  • favus
epiglottitis
  • acute epiglottitis
- elite association - COSMIC cancer census association via MalaCards
Search RDH11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RDH11_HUMAN
  • Retinal dystrophy, juvenile cataracts, and short stature syndrome (RDJCSS) [MIM:616108]: A disorder characterized by retinal dystrophy resulting in progressive decrease in visual acuity and difficulties with night vision in the first decade of life, development of juvenile cataracts, facial dysmorphism, psychomotor developmental delays, learning disabilities and short stature. Ophthalmological findings include salt-and-pepper retinopathy, attenuation of the arterioles, generalized rod-cone dysfunction, mottled macula at an early age, and peripapillary sparing of the retinal pigment epithelium. {ECO:0000269 PubMed:24916380}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RDH11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RDH11
genes like me logo Genes that share disorders with RDH11: view

No data available for Genatlas for RDH11 Gene

Publications for RDH11 Gene

  1. Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium. (PMID: 11245473) Lin B. … Nelson P.S. (Cancer Res. 2001) 3 4 23 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids. (PMID: 16787387) Gallego O. … Kedishvili N.Y. (Biochem. J. 2006) 23 25
  4. Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins. (PMID: 12807874) Kasus-Jacobi A. … Brown M.S. (J. Biol. Chem. 2003) 3 23
  5. Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines. (PMID: 14674758) Belyaeva O.V. … Kedishvili N.Y. (Biochemistry 2003) 3 23

Products for RDH11 Gene

Sources for RDH11 Gene

Content