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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RDH11 Gene

protein-coding GIFtS: 61
GCID: GC14M068143

retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

(Previous name: retinol dehydrogenase 11 (all-trans and 9-cis) )

Explore 14 diseases affiliated with
RDH11 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Retinol Dehydrogenase 11 (All-Trans/9-Cis/11-Cis)¹ ²		Retinol Dehydrogenase 11 (All-Trans And 9-Cis)¹
ARSDR1¹ ² ³		CGI82²
PSDR1² ³ ⁵		HCBP12²
MDT1¹ ²		SCALD²
SDR7C1¹ ²		Prostate Short-Chain Dehydrogenase Reductase 1²
Androgen-Regulated Short-Chain Dehydrogenase/Reductase 1² ³		Retinol Dehydrogenase 11²
Prostate Short-Chain Dehydrogenase/Reductase 1² ³		Short Chain Dehydrogenase/Reductase Family 7C, Member 1²
Retinal Reductase 1² ³		EC 1.1.1.300³
HCV Core-Binding Protein HCBP12² ³		RalR1³
RALR1² ⁵

External Ids:	HGNC: 17964¹	Entrez Gene: 51109²	Ensembl: ENSG00000072042⁷	OMIM: 607849⁵	UniProtKB: Q8TC12³

Export aliases for RDH11 gene to outside databases

Previous GC identifers: GC14M061937 GC14M066133 GC14M067213 GC14M048313

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RDH11:

The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The

encoded protein has no steroid dehydrogenase activity. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: RDH11_HUMAN, Q8TC12

Function: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal

reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain

aldehydes. No steroid dehydrogenase activity detected

Gene Wiki entry for RDH11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RDH11 gene promoter:
MyoD NF-AT Arnt AREB6 NF-AT4 NF-AT2 STAT3 c-Myb NF-AT3 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RDH11 promoter sequence

Search SABiosciences Chromatin IP Primers for RDH11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RDH11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1 Ensembl cytogenetic band: 14q24.1 HGNC cytogenetic band: 14q24.1

RDH11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RDH11 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M068143: view genomic region (about GC identifiers)

Start:	68,143,517 bp from pter	End:	68,162,531 bp from pter
Size:	19,015 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RDH11_HUMAN, Q8TC12 (See protein sequence)

Recommended Name: Retinol dehydrogenase 11

Size: 318 amino acids; 35386 Da

Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein

Secondary accessions: A6NDK3 A8K062 B2RB26 Q6IAH5 Q9NRW0 Q9Y391

Alternative splicing: 2 isoforms: Q8TC12-1 Q8TC12-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RDH11: NX_Q8TC12

Post-translational modifications:

Not glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TC12

RDH11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001239579.1 NP_057110.3

ENSEMBL proteins:

ENSP00000370750 ENSP00000452079 ENSP00000416395 ENSP00000451280 ENSP00000450802

ENSP00000450651 ENSP00000450435 ENSP00000452108

Reactome Protein details: Q8TC12
Human Recombinant Protein Products:

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	Uscn Proteins for RDH11

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001917	photoreceptor inner segment	IEA	--
GO:0005622	intracellular	ISS	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

RDH11 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RDH11 for domains About GeneDecksing

3 InterPro domains/families:

IPR002347 Glc/ribitol_DH

IPR002198 DH_sc/Rdtase_SDR

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q8TC12

ProtoNet protein and cluster: Q8TC12

2 Blocks protein families:

IPB002198 Short-chain dehydrogenase/reductase SDR

IPB002347 Glucose/ribitol dehydrogenase family signature

UniProtKB/Swiss-Prot: RDH11_HUMAN, Q8TC12

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RDH11_HUMAN, Q8TC12

Function: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal

reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain

aldehydes. No steroid dehydrogenase activity detected

Catalytic activity: All-trans-retinol + NADP(+) = all-trans-retinal + NADPH

Biophysicochemical properties: Kinetic parameters: KM=0.23 uM for NADPH; KM=0.8 uM for NADP; KM=0.5 uM for

all-trans-retinal; KM=0.62 uM for 13-cis-retinal; KM=0.19 uM for 9-cis-retinal; KM=1.3 uM for all-trans-retinol;

Vmax=18 nmol/min/mg enzyme with all-trans-retinal as substrate; Vmax=7 nmol/min/mg enzyme with 13-cis-retinal as

substrate; Vmax=1.6 nmol/min/mg enzyme with 9-cis-retinal as substrate; Vmax=0.95 nmol/min/mg enzyme with

all-trans-retinol as substrate; Note=Vmax is measured per mg microsomal protein;

Induction: By androgens in prostate cancer cells

Enzyme Number (IUBMB): EC 1.1.1.300¹

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RDH11

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004745	retinol dehydrogenase activity	ISS	--
GO:0016491	oxidoreductase activity	--	--
GO:0052650	NADP-retinol dehydrogenase activity	IDA	12807874

RDH11 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for RDH11: Rdh11^tm1Tsyk Rdh11^tm1Akjc
     2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rdh11):

reproductive system

vision/eye

RDH11 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

the visual cycle I (vertebrates)

	the visual cycle I (vertebrates)	1.00			The canonical retinoid cycle in rods (twilight vision)	0.50
	retinol biosynthesis	0.52

Retinoid metabolism and transport

	Retinoid metabolism and transport	1.00			Diseases associated with visual transduction	0.73
	Visual phototransduction	0.74

Retinol metabolism

Retinol metabolism

1.00

Retinol metabolism

0.95

Disease

Disease

1.00

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for RDH11

Retinol metabolism

1 GeneGo (Thomson Reuters) Pathway for RDH11

Retinol metabolism

2 BioSystems Pathways for RDH11

	the visual cycle I (vertebrates)
	retinol biosynthesis

5/6 Reactome Pathways for RDH11 (see all 6)

	Diseases associated with visual transduction
	Retinoid metabolism and transport
	Signal Transduction
	The canonical retinoid cycle in rods (twilight vision)
	Visual phototransduction

2 Kegg Pathways (Kegg details for RDH11):

	Retinol metabolism
	Metabolic pathways

RDH11 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RDH11

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/18 Interacting proteins for RDH11 (Q8TC12^{2, 3} ENSP00000370750⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CA12	O43570²^,³, ENSP00000178638⁴	MINT-8268603 I2D: score=2 STRING: ENSP00000178638
BLOC1S2	Q6QNY1²^,³	MINT-8268592 I2D: score=2
ROBO2	Q9HCK4²^,³, ENSP00000417164⁴	MINT-8268625 I2D: score=2 STRING: ENSP00000417164
GRB2	P62993³	I2D: score=2
DDA1	Q9BW61³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001523	retinoid metabolic process	TAS	--
GO:0008202	steroid metabolic process	TAS	--
GO:0016062	adaptation of rhodopsin mediated signaling	IEA	--
GO:0042572	retinol metabolic process	ISS	--
GO:0042574	retinal metabolic process	IDA	12807874

RDH11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RDH11 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RDH11

1 HMDB Compound for RDH11 About this table

Compound	Synonyms	CAS #	PubMed Ids
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--

1 DrugBank Compound for RDH11 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Vitamin A	[11,12-3H]-Retinol (see all 18)	68-26-8	target	--	16787387

2 Novoseek chemical compound relationships for RDH11 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vitamin a	71.4	5	14674758 (1), 12807874 (1), 16787387 (1)
nadph	52.3	2	18039331 (1), 12036956 (1)

Search CenterWatch for drugs/clinical trials and news about RDH11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RDH11 gene (2 alternative transcripts):

NM_001252650.1 NM_016026.3

Unigene Cluster for RDH11:

Retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

Hs.719925 [show with all ESTs]

Unigene Representative Sequence: AB209223

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000381346(uc001xjv.4 uc001xjx.4 uc001xjw.4) ENST00000553384

ENST00000553578 ENST00000428130 ENST00000554731 ENST00000554035 ENST00000553816

ENST00000557273 ENST00000557726 ENST00000557331 ENST00000556692

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		hsa-miR-3128 hsa-miR-92a-1* hsa-miR-628-3p hsa-miR-519e* hsa-miR-211 hsa-miR-515-5p hsa-miR-204 hsa-miR-376a*

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Additional cDNA sequence:

AB209223.1 AF151840.1 AF167438.1 AF395068.1 AK001494.1 AK057195.1 AK074749.1 AK289427.1

AK293355.1 AK307500.1 AK314465.1 AL096716.1 BC000112.1 BC011727.2 BC026274.1 BC037302.1

BC051291.1 CR457180.1 DQ426886.1

24/39 DOTS entries (see all 39):

DT.91960564 DT.414230 DT.92426971 DT.100765475 DT.100860746 DT.97816947 DT.87017583 DT.75131103

DT.91866886 DT.95167332 DT.99948819 DT.95167336 DT.100858811 DT.120767759 DT.97864689 DT.91766449

DT.100676765 DT.100829383 DT.100836137 DT.120767772 DT.92343222 DT.95310460 DT.100841328 DT.101984917

24/1100 AceView cDNA sequences (see all 1100):

BM007952 BQ690535 AI686225 BU726533 AI474570 BF436820 AI912160 BM833384

BF026492 BX367789 AI659469 AI719735 AA365565 BF025693 CB216513 AA652561

BF436856 AA814663 BU541969 BQ632456 CB160058 AA779908 AA399559 AI620454

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for RDH11 (see all 13) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	^	8	^	9a	·
SP1:																					-										-				-												-		-
SP2:																	-		-		-										-				-												-		-
SP3:																			-		-		-								-				-												-		-
SP4:																					-										-		-		-												-		-
SP5:																					-										-		-		-

ExUns:	9b	·	9c	·	9d	·	9e	·	9f	·	9g
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RDH11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RDH11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTAGCAGGG

About this image

RDH11 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RDH11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RDH11

SOURCE GeneReport for Unigene cluster: Hs.719925

UniProtKB/Swiss-Prot: RDH11_HUMAN, Q8TC12

Tissue specificity: Predominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory

cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood

leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular stromal cells, endothelial

cells, or infiltrating lymphocytes

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RDH11 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	E1BTL3_CHICK⁶	Uncharacterized protein	64(a)	1 → many	5(31186027-31192136)
lizard (Anolis carolinensis)	Reptilia	-- --	--	65(a) 61(a)	many ↔ many many ↔ many	GL343272.1(1094499-1102885) GL343272.1(1035368-1048563)
zebrafish (Danio rerio)	Actinopterygii	rdh12⁶ si:dkey-94e7.2⁶ (see all 8)	si:dkey-94e7.2 (see all 8)	63(a) 54(a) (see all 8)	1 ↔ many possible ortholog (see all 8)	13(33279150-33289445) 2(30435902-30441252)
mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP007572¹	AGAP007572-PA	54.5(n) 53.68(a)		1269657 XM_308302.4 XP_308302.4
worm (Caenorhabditis elegans)	Secernentea	dhs-1⁶	DeHydrogenases, Short chain family member (dhs-1)	25(a)	possible ortholog	I(5278807-5281519)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G53100⁶ FEY⁶ (see all 3)	Rossmann-fold NAD(P)-binding domain-containing pro... Rossmann-fold NAD(P)-binding domain-containing pro... (see all 3)	25(a) 25(a) (see all 3)	possible ortholog possible ortholog (see all 3)	5(21526250-21528323) 4(13844065-13846746)
rice (Oryza sativa)	Liliopsida	Os11g0181800¹	hypothetical protein	48.75(n) 44.09(a)		4349945 NM_001072434.1 NP_001065902.1

ENSEMBL Gene Tree for RDH11 (if available)
TreeFam Gene Tree for RDH11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RDH11 gene

ENSG00000267149² RDH13² DHRS12² WWOX² DHRSX² RDH12² RDH14² DHRS13²

9 SIMAP similar genes for RDH11 using alignment to 9 protein entries: RDH11_HUMAN (see all proteins):

RDH12 NT5C1B-RDH14 RDH13 DHRSX RDH14 DHRS13

DHRS12 WWOX HSD17B7

RDH11 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for RDH11
PGOHUM00000240096

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77173642^1,2	C	--	68143866(+)	`GGGAAA/CACTAC`	2	--	ut3¹		0	--	--	--	--
rs199566697^1,2	C,	--	68143910(+)	`TTGAT-/AAGAAGTC`	2	--	ut3¹		0	--	--	--	--
rs145780940^1,2	C,	--	68144060(+)	`TTTTT-/TTTG TTTGT`	2	--	ut3¹		0	--	--	--	--
rs199532098^1,2	C	--	68144063(+)	`TTTTTG/TTTTGT`	2	--	ut3¹		0	--	--	--	--
rs1059238^1,2	C,F,A,H,	--	68144191(-)	`AAAGAT/CATTAA`	2	--	ut3¹		22		MN NA NS EA CSA WA	2668
rs186380369^1,2		--	68144322(+)	`ATGTGC/GTCTTG`	2	--	ut3¹		0	--	--	--	--
rs7765^1,2	C,F,H,	--	68144329(-)	`TACCCA/GCCAAG`	2	--	ut3¹ ese³		17		MN NA NS EA CSA WA	1816
rs7410^1,2	C,F,A,H,	--	68144423(+)	`GATTAT/CTGTGG`	2	--	ut3¹ ese³		18		MN NA NS EA	1891
rs150056845^1,2		--	68144430(+)	`TGGCT-/GGGTTTT`	2	--	ut3¹		0	--	--	--	--
rs74848574^1,2	F,	--	68144585(+)	`AGCCCT/CGCTCC`	2	--	ut3¹		1		EA	120

HapMap Linkage Disequilibrium report for RDH11 (68143517 - 68162531 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RDH11: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RDH11

DNA2.0 Custom Variant and Variant Library Synthesis for RDH11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RDH11 for disorders           About GeneDecksing

OMIM gene information: 607849    OMIM disorders: --

14 diseases for RDH11:    About MalaCards

retinitis prostatitis toxic shock syndrome epiglottitis

muscular atrophy respiratory failure hepatitis c hepatocellular carcinoma

prostate cancer hepatitis cholesterol tuberculosis

carcinoma mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for RDH11:

Epiglottitis

1 Novoseek disease relationship for RDH11 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0	1	14674758 (1)

Export disorders for RDH11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RDH11 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with RDH11)

Utopia: connect your pdf to the dynamic
world of online information

Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium. (PubMed id 11245473)^{1, 2, 9} Lin B.... Nelson P.S. (2001)
Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1). (PubMed id 12036956)^{1, 2, 9} Kedishvili N.Y.... Nelson P.S. (2002)
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)^{1, 3} Persson B.... Oppermann U. (2009)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. (PubMed id 12226107)^{1, 3} Haeseleer F.... Palczewski K. (2002)
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2} Lai C.H....Lin W. (2000)
Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line. (PubMed id 8018917)^{1, 3} Hara T....Miyajima A. (1994)
Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins. (PubMed id 12807874)^{1, 9} Kasus-Jacobi A....Brown M.S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51109	HGNC: 17964	AceView: VTI1B	Ensembl:ENSG00000072042	euGenes: HUgn51109
ECgene: RDH11	Kegg: 51109	H-InvDB: RDH11

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RDH11	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RDH11	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RDH11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RDH11 gene:
Search GeneIP for patents involving RDH11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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RDH11 Gene

retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

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RDH11 (Gene Symbol)
Retinol Dehydrogenase 11 (All-Trans/9-Cis/11-Cis)
ARSDR1
PSDR1
MDT1
SDR7C1
Androgen-Regulated Short-Chain Dehydrogenase/Reductase 1
Prostate Short-Chain Dehydrogenase/Reductase 1
Retinal Reductase 1
HCV Core-Binding Protein HCBP12
RALR1
Retinol Dehydrogenase 11 (All-Trans And 9-Cis)
CGI82
HCBP12
SCALD
Prostate Short-Chain Dehydrogenase Reductase 1
Retinol Dehydrogenase 11
Short Chain Dehydrogenase/Reductase Family 7C, Member 1
EC 1.1.1.300
RalR1

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RDH11 Gene

retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

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