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RDH11 Gene

protein-coding   GIFtS: 61
GCID: GC14M068143

Retinol Dehydrogenase 11 (All-Trans/9-Cis/11-Cis)

(Previous name: retinol dehydrogenase 11 (all-trans and 9-cis))
  See RDH11-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Retinol Dehydrogenase 11 (All-Trans/9-Cis/11-Cis)1 2     CGI822
Androgen-Regulated Short-Chain Dehydrogenase/Reductase 11 2 3     HCBP122
PSDR12 3 5     MDT12
Prostate Short-Chain Dehydrogenase/Reductase 12 3     SCALD2
Retinal Reductase 12 3     SDR7C12
ARSDR12 3     Prostate Short-Chain Dehydrogenase Reductase 12
HCV Core-Binding Protein HCBP122 3     Retinol Dehydrogenase 112
RALR12 5     Short Chain Dehydrogenase/Reductase Family 7C, Member 12
Member 11     EC 1.1.1.3003
Retinol Dehydrogenase 11 (All-Trans And 9-Cis)1     RalR13
Short Chain Dehydrogenase/Reductase Family 7C1     

External Ids:    HGNC: 179641   Entrez Gene: 511092   Ensembl: ENSG000000720427   OMIM: 6078495   UniProtKB: Q8TC123   

Export aliases for RDH11 gene to outside databases

Previous GC identifers: GC14M061937 GC14M066133 GC14M067213 GC14M048313


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RDH11 Gene:
The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain
dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. (provided by RefSeq, Nov
2011)

GeneCards Summary for RDH11 Gene:
RDH11 (retinol dehydrogenase 11 (all-trans/9-cis/11-cis)) is a protein-coding gene. Diseases associated with RDH11 include epiglottitis. GO annotations related to this gene include NADP-retinol dehydrogenase activity and retinol dehydrogenase activity. An important paralog of this gene is RDH13.

UniProtKB/Swiss-Prot: RDH11_HUMAN, Q8TC12
Function: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent
retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of
short-chain aldehydes. No steroid dehydrogenase activity detected

Gene Wiki entry for RDH11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RDH11 gene promoter:
         MyoD   NF-AT   Arnt   AREB6   NF-AT4   NF-AT2   STAT3   c-Myb   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRDH11 promoter sequence
   Search Chromatin IP Primers for RDH11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RDH11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q24.1

RDH11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RDH11 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M068143:  view genomic region     (about GC identifiers)

Start:
68,143,517 bp from pter      End:
68,162,531 bp from pter
Size:
19,015 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RDH11_HUMAN, Q8TC12 (See protein sequence)
Recommended Name: Retinol dehydrogenase 11  
Size: 318 amino acids; 35386 Da
Secondary accessions: A6NDK3 A8K062 B2RB26 B4DDW0 Q0QD40 Q6IAH5 Q9NRW0 Q9Y391
Alternative splicing: 3 isoforms:  Q8TC12-1   Q8TC12-2   Q8TC12-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RDH11: NX_Q8TC12

Explore proteomics data for RDH11 at MOPED

Post-translational modifications: 

  • Not glycosylated1
  • Ubiquitination2 at Lys83, Lys105, Lys112, Lys194
  • Modification sites at PhosphoSitePlus

  • See RDH11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001239579.1  NP_057110.3  

    ENSEMBL proteins: 
     ENSP00000370750   ENSP00000452079   ENSP00000416395   ENSP00000451280   ENSP00000450802  
     ENSP00000450651   ENSP00000450435   ENSP00000452108  
    Reactome Protein details: Q8TC12

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRC2: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 2

    3 InterPro protein domains:
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8TC12

    ProtoNet protein and cluster: Q8TC12

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: RDH11_HUMAN, Q8TC12
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    Find genes that share domains with RDH11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RDH11_HUMAN, Q8TC12
    Function: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent
    retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of
    short-chain aldehydes. No steroid dehydrogenase activity detected
    Catalytic activity: All-trans-retinol + NADP(+) = all-trans-retinal + NADPH
    Biophysicochemical properties: Kinetic parameters: KM=0.23 uM for NADPH; KM=0.8 uM for NADP; KM=0.5 uM for
    all-trans-retinal; KM=0.62 uM for 13-cis-retinal; KM=0.19 uM for 9-cis-retinal; KM=1.3 uM for all-trans-retinol;
    Vmax=18 nmol/min/mg enzyme with all-trans-retinal as substrate; Vmax=7 nmol/min/mg enzyme with 13-cis-retinal as
    substrate; Vmax=1.6 nmol/min/mg enzyme with 9-cis-retinal as substrate; Vmax=0.95 nmol/min/mg enzyme with
    all-trans-retinol as substrate; Note=Vmax is measured per mg microsomal protein;
    Induction: By androgens in prostate cancer cells

         Enzyme Number (IUBMB): EC 1.1.1.3001

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004745retinol dehydrogenase activity ISS--
    GO:0016491oxidoreductase activity ----
    GO:0050662coenzyme binding ----
    GO:0052650NADP-retinol dehydrogenase activity IDA12807874
         
    Find genes that share ontologies with RDH11           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rdh11):
     reproductive system  vision/eye 

    Find genes that share phenotypes with RDH11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RDH11: Rdh11tm1Tsyk Rdh11tm1Akjc

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    Block miRNA regulation of human, mouse, rat RDH11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RDH11 (see all 12):
    hsa-miR-3128 hsa-miR-92a-1* hsa-miR-628-3p hsa-miR-519e* hsa-miR-211 hsa-miR-515-5p hsa-miR-204 hsa-miR-376a*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RDH11_HUMAN, Q8TC12: Endoplasmic reticulum membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2
    cytosol1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001917photoreceptor inner segment IEA--
    GO:0005622intracellular ISS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with RDH11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RDH11 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1the visual cycle I (vertebrates)
    the visual cycle I (vertebrates)0.52
    The canonical retinoid cycle in rods (twilight vision)0.44
    retinol biosynthesis0.52
    2Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    Retinoid metabolism and transport0.44
    3Signaling by GPCR
    Signal Transduction0.58
    4Metabolism
    Metabolic pathways0.38
    5Chemical carcinogenesis
    Retinol metabolism0.35


    Find genes that share SuperPaths with RDH11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RDH11
        Visual Cycle in Retinal Rods

    1 GeneGo (Thomson Reuters) Pathway for RDH11
        Retinol metabolism

    2 BioSystems Pathways for RDH11
        retinol biosynthesis
    the visual cycle I (vertebrates)


    2 Reactome Pathways for RDH11
        Retinoid metabolism and transport
    The canonical retinoid cycle in rods (twilight vision)


    2 Kegg Pathways  (Kegg details for RDH11):
        Retinol metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RDH11
    Interactions:

        Search GeneGlobe Interaction Network for RDH11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RDH11 (Q8TC122, 3 ENSP000003707504) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CA12O435702, 3, ENSP000001786384MINT-8268603 I2D: score=2 STRING: ENSP00000178638
    BLOC1S2Q6QNY12, 3MINT-8268592 I2D: score=2 
    ROBO2Q9HCK42, 3, ENSP000004171644MINT-8268625 I2D: score=2 STRING: ENSP00000417164
    GRB2P629933I2D: score=2 
    DDA1Q9BW613I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0007603phototransduction, visible light TAS--
    GO:0008152metabolic process ----
    GO:0016062adaptation of rhodopsin mediated signaling IEA--
    GO:0042572retinol metabolic process ISS--

    Find genes that share ontologies with RDH11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RDH11

    1 HMDB Compound for RDH11    About this table
    CompoundSynonyms CAS #PubMed Ids
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    1 DrugBank Compound for RDH11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin A[11,12-3H]-Retinol (see all 18)68-26-8target--16787387

    2 Novoseek inferred chemical compound relationships for RDH11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin a 71.4 5 14674758 (1), 12807874 (1), 16787387 (1)
    nadph 52.3 2 18039331 (1), 12036956 (1)



    Find genes that share compounds with RDH11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RDH11 gene (2 alternative transcripts): 
    NM_001252650.1  NM_016026.3  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381346(uc001xjv.4 uc001xjx.4 uc001xjw.4) ENST00000553384
    ENST00000553578 ENST00000428130 ENST00000554731 ENST00000554035 ENST00000553816
    ENST00000557273 ENST00000557726 ENST00000557331 ENST00000556692
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    Selected AceView cDNA sequences (see all 1100):

    BF203750 AI963481 BM044225 BM721186 BE267556 AI056325 BQ947895 BQ890697 
    BE273727 BM661519 BE294361 BP360309 BU955833 BU541331 BE408821 CA419546 
    BE407156 BM128395 AW519091 BI114283 BM272282 BI825624 AA306983 BQ775842 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RDH11 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a ·
    SP1:                                                              -                             -           -                                   -     -         
    SP2:                                                  -     -     -                             -           -                                   -     -         
    SP3:                                                        -     -     -                       -           -                                   -     -         
    SP4:                                                              -                             -     -     -                                   -     -         
    SP5:                                                              -                             -     -     -                                                   

    ExUns: 9b · 9c · 9d · 9e · 9f · 9g
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RDH11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RDH11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAGCAGGG
    RDH11 Expression
    About this image


    RDH11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Kidney (Urinary System)
     
     Thyroid (Endocrine System)
     
     Adrenal Gland (Endocrine System)
    RDH11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RDH11 Protein Expression

    UniProtKB/Swiss-Prot: RDH11_HUMAN, Q8TC12
    Tissue specificity: Predominantly expressed in the epithelial cells of prostate, in both basal and luminal
    secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon,
    peripherical blood leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular
    stromal cells, endothelial cells, or infiltrating lymphocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RDH11 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rdh111 , 5 retinol dehydrogenase 111, 5 83.06(n)1
    86.38(a)1
      12 (35.51 cM)5
    172521  NM_021557.51  NP_067532.21 
     791743375 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    63(a)
    1 → many
    5(28165238-28170987)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    66(a)
    65(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343272.1(1049956-1102885)
    GL343272.1(1032418-1064517)
    zebrafish
    (Danio rerio)
    Actinopterygii rdh126
    retinol dehydrogenase 12 (all-trans and 9-cis)
    63(a)
    1 → many
    13(33279150-33289432) ENSDARG00000018069
    fruit fly
    (Drosophila melanogaster)
    Insecta CG20651 CG2065 56.36(n)
    55.64(a)
      35707  NM_136465.4  NP_610309.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-221 dhs-22 44.6(n)
    38.38(a)
      179940  NM_074169.4  NP_506570.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G025401 AT5G02540 52.29(n)
    43.49(a)
      831913  NM_120332.3  NP_568102.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01517001 Os01g0151700 50.6(n)
    46.07(a)
      4324493  NM_001048577.1  NP_001042042.1 


    ENSEMBL Gene Tree for RDH11 (if available)
    TreeFam Gene Tree for RDH11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RDH11 gene
    RDH132  ENSG000002584662  DHRS122  WWOX2  DHRSX2  RDH122  DHRS132  RDH142  
    8 SIMAP similar genes for RDH11 using alignment to 7 protein entries:     RDH11_HUMAN (see all proteins):
    RDH12    NT5C1B-RDH14    RDH13    RDH14    DHRSX    DHRS13
    DHRS12    WWOX

    Find genes that share paralogs with RDH11           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RDH11
    PGOHUM00000240096


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RDH11 (see all 440)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs771736421,2
    C--68143866(+) GGGAAA/CACTAC 2 -- ut310--------
    rs1995666971,2
    C--68143910(+) TTGAT-/AAGAAGTC 2 -- cds10--------
    rs1457809401,2
    C--68144060(+) TTTTT-/TTTG  
            
    TTTGT
    2 -- ut310--------
    rs1995320981,2
    C--68144063(+) TTTTTG/TTTTGT 2 -- ut310--------
    rs10592381,2
    C,F,A,H--68144191(-) AAAGAT/CATTAA 2 -- ut3122Minor allele frequency- C:0.18MN NA NS EA CSA WA 2668
    rs1863803691,2
    --68144322(+) ATGTGC/GTCTTG 2 -- ut310--------
    rs77651,2
    C,F,H--68144329(-) TACCCA/GCCAAG 2 -- ut31 ese317Minor allele frequency- G:0.11MN NA NS EA CSA WA 1816
    rs74101,2
    C,F,A,H--68144423(+) GATTAT/CTGTGG 2 -- ut31 ese318Minor allele frequency- C:0.07MN NA NS EA 1891
    rs1500568451,2
    C--68144430(+) TGGCT-/GGGTTTT 2 -- ut310--------
    rs748485741,2
    C,F--68144585(+) AGCCCT/CGCTCC 2 -- ut311Minor allele frequency- C:0.07EA 120

    HapMap Linkage Disequilibrium report for RDH11 (68143517 - 68162531 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RDH11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521832CNV Loss19592680
    nsv902068CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RDH11
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607849    OMIM disorders: --

    1 disease for RDH11:    
    About MalaCards
    epiglottitis

    1 disease from the University of Copenhagen DISEASES database for RDH11:
    Epiglottitis

    Find genes that share disorders with RDH11           About GenesLikeMe

    1 Novoseek inferred disease relationship for RDH11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 14674758 (1)


    Export disorders for RDH11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RDH11 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with RDH11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium. (PubMed id 11245473)1, 2, 9 Lin B.... Nelson P.S. (Cancer Res. 2001)
    2. Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1). (PubMed id 12036956)1, 2, 9 Kedishvili N.Y.... Nelson P.S. (J. Biol. Chem. 2002)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    4. Mapping of transcription start sites of human retina expressed genes. (PubMed id 17286855)1, 2 Roni V.... Wissinger B. (BMC Genomics 2007)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. (PubMed id 12226107)1, 3 Haeseleer F.... Palczewski K. (J. Biol. Chem. 2002)
    9. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    10. Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line. (PubMed id 8018917)1, 3 Hara T....Miyajima A. (Blood 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51109 HGNC: 17964 AceView: VTI1B Ensembl:ENSG00000072042 euGenes: HUgn51109
    ECgene: RDH11 Kegg: 51109 H-InvDB: RDH11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RDH11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RDH11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RDH11 gene:
    Search GeneIP for patents involving RDH11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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