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RDH10 Gene

protein-coding   GIFtS: 57
GCID: GC08P074207

Retinol Dehydrogenase 10 (All-Trans)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Retinol Dehydrogenase 10 (All-Trans)1 2     Short Chain Dehydrogenase/Reductase Family 16C, Member 42
Member 41     EC 1.1.1.3003
Short Chain Dehydrogenase/Reductase Family 16C1     EC 1.1.18
SDR16C42     EC 1.1.1.n28
Retinol Dehydrogenase 102     

External Ids:    HGNC: 199751   Entrez Gene: 1575062   Ensembl: ENSG000001210397   OMIM: 6075995   UniProtKB: Q8IZV53   

Export aliases for RDH10 gene to outside databases

Previous GC identifers: GC08P074147 GC08P073930 GC08P074257 GC08P074369 GC08P069698


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RDH10 Gene:
This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference
for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic
retinoic acid and is required for limb, craniofacial, and organ development. (provided by RefSeq, Dec 2011)

GeneCards Summary for RDH10 Gene:
RDH10 (retinol dehydrogenase 10 (all-trans)) is a protein-coding gene. Diseases associated with RDH10 include fundus albipunctatus, and retinitis. GO annotations related to this gene include NADP-retinol dehydrogenase activity and retinol dehydrogenase activity. An important paralog of this gene is HSD17B13.

UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5
Function: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal.
Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RDH10 gene promoter:
         AML1a   Pax-5   FOXO4   Sox9   Pax-4a   HNF-3beta   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RDH10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RDH10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q21.11

RDH10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RDH10 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P074207:  view genomic region     (about GC identifiers)

Start:
74,206,847 bp from pter      End:
74,237,516 bp from pter
Size:
30,670 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5 (See protein sequence)
Recommended Name: Retinol dehydrogenase 10  
Size: 341 amino acids; 38087 Da

Explore the universe of human proteins at neXtProt for RDH10: NX_Q8IZV5

Explore proteomics data for RDH10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys319
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RDH10 (Q8IZV5) (see all 12)
     TTKAFLP  YCASKFGV  VLWAFVLAA  GADKCMYPF 


    See RDH10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_742034.1  
    ENSEMBL proteins: 
     ENSP00000240285   ENSP00000429727   ENSP00000428132  
    Reactome Protein details: Q8IZV5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRC3: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8IZV5

    ProtoNet protein and cluster: Q8IZV5

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    RDH10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RDH10_HUMAN, Q8IZV5
    Function: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal.
    Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol
    Catalytic activity: All-trans-retinol + NADP(+) = all-trans-retinal + NADPH

         Enzyme Numbers (IUBMB): EC 1.1.1.3001 EC 1.1.1.n22 EC 1.1.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004745retinol dehydrogenase activity IDA12407145
    GO:0016491oxidoreductase activity ----
    GO:0052650NADP-retinol dehydrogenase activity IEA--
         
    RDH10 for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Rdh10) (see all 21):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism 
     limbs/digits/tail  liver/biliary system  mortality/aging  nervous system  normal 

    RDH10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RDH10: Rdh10tm1d(KOMP)Wtsi Rdh10tm1.1Ics Rdh10tm2Ics

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RDH10
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    miRNA
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    miRTarBase miRNAs that target RDH10:
    hsa-let-7b-5p (MIRT001600), hsa-mir-196a-5p (MIRT026079), hsa-mir-124-3p (MIRT003051)

    Block miRNA regulation of human, mouse, rat RDH10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RDH10 (see all 62):
    hsa-miR-579 hsa-miR-3607-3p hsa-let-7d hsa-miR-429 hsa-miR-4305 hsa-let-7g hsa-miR-374c hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidRDH10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RDH10

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RDH10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RDH10_HUMAN, Q8IZV5: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum
    membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634NOT nucleus IDA19458327
    GO:0005737cytoplasm IDA19458327
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IDA19458327

    RDH10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RDH10 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1the visual cycle I (vertebrates)
    the visual cycle I (vertebrates)0.52
    The canonical retinoid cycle in rods (twilight vision)0.44
    retinol biosynthesis0.52
    2Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    3Signaling by GPCR
    Signal Transduction0.58
    4Metabolism
    Metabolic pathways0.38
    5Chemical carcinogenesis
    Retinol metabolism0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RDH10
        Visual Cycle in Retinal Rods

    3 BioSystems Pathways for RDH10
        Vitamin A and carotenoid metabolism
    retinol biosynthesis
    the visual cycle I (vertebrates)

    1 Reactome Pathway for RDH10
        The canonical retinoid cycle in rods (twilight vision)


    2 Kegg Pathways  (Kegg details for RDH10):
        Retinol metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5
    Pathway: Cofactor metabolism; retinol metabolism


    RDH10 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RDH10
    Interactions:

        Search GeneGlobe Interaction Network for RDH10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for RDH10 (ENSP000002402854) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    BCMO1ENSP000002581684STRING: ENSP00000258168
    CYP26A1ENSP000002243564STRING: ENSP00000224356
    DGAT1ENSP000003322584STRING: ENSP00000332258
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0001656metanephros development IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0002138retinoic acid biosynthetic process IEA--
    GO:0007601visual perception IDA12407145

    RDH10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RDH10

    3 HMDB Compounds for RDH10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glucosylceramide (d18:1/20:0)1-O-b-D-glucopyranosyl-Ceramide (see all 8)85305-87-9--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    2 Novoseek inferred chemical compound relationships for RDH10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin a 77 24 19102727 (3), 12407145 (3), 19141675 (2), 15505029 (2) (see all 8)
    retinoic acid 66.4 8 19141675 (2), 19102727 (1), 19592647 (1), 16982809 (1) (see all 5)



    RDH10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RDH10 gene: 
    NM_172037.4  

    Unigene Cluster for RDH10:

    Retinol dehydrogenase 10 (all-trans)
    Hs.244940  [show with all ESTs]
    Unigene Representative Sequence: NM_172037
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240285(uc003xzi.3 uc003xzj.3) ENST00000518870 ENST00000521928
    ENST00000519380 ENST00000521013
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RDH10 (see all 62):
    hsa-miR-579 hsa-miR-3607-3p hsa-let-7d hsa-miR-429 hsa-miR-4305 hsa-let-7g hsa-miR-374c hsa-miR-124
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    Additional mRNA sequence: 

    AF456765.1 AY358270.1 BC067131.1 

    5 DOTS entries:

    DT.103193  DT.95253713  DT.100776423  DT.92420860  DT.99994312 

    Selected AceView cDNA sequences (see all 141):

    BQ016440 CA503115 BM069775 CN483597 CB134622 BM708760 CA393380 BM979244 
    AI473142 AI758385 CB158210 AI363760 AI150994 BM726396 AI095886 BE857123 
    AA873846 BM993657 AA343664 CA428638 AI627313 CA309760 BU608508 CD677140 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RDH10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTCAGGA
    RDH10 Expression
    About this image


    RDH10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Limb (Muscoskeletal System)
             Autopod
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
     
     Kidney (Urinary System)
             Metanephros
    RDH10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RDH10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.244940

    UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5
    Tissue specificity: Detected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RDH10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RDH10 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rdh101 , 5 retinol dehydrogenase 10 (all-trans)1, 5 92.28(n)1
    98.83(a)1
      1 (4.94 cM)5
    987111  NM_133832.31  NP_598593.11 
     161057745 
    chicken
    (Gallus gallus)
    Aves RDH101 retinol dehydrogenase 10 (all-trans) 84.37(n)
    92.33(a)
      420183  NM_001199459.1  NP_001186388.1 
    lizard
    (Anolis carolinensis)
    Reptilia RDH106
    retinol dehydrogenase 10 (all-trans)
    91(a)
    1 ↔ 1
    4(33475549-33516185)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.243992 Xenopus laevis transcribed sequence with weak similarity more 79.73(n)    CB207153.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rdh102 retinol dehydrogenase 10 78.47(n)   378722  BC054596.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG156296
    CG92656
    --
    35(a)
    27(a)
    many ↔ many
    many ↔ many
    2L(4813009-4815891)
    2L(21057706-21071502)
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-296
    Protein DHS-29 (dhs-29) mRNA, complete cds
    20(a)
    many ↔ many
    X(7661902-7664914) WBGene00000992
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    TDA56
    Putative protein of unknown function with similari...
    Putative protein of unknown function; detected in ...
    23(a)
    20(a)
    many ↔ many
    many ↔ many
    IV(255604-256530) YDL114W
    XII(987062-988113) YLR426W


    ENSEMBL Gene Tree for RDH10 (if available)
    TreeFam Gene Tree for RDH10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RDH10 gene
    HSD17B132  HSD17B112  DHRS32  SDR16C52  
    5 SIMAP similar genes for RDH10 using alignment to 3 protein entries:     RDH10_HUMAN (see all proteins):
    DHRS3    SDR16C5    HPGD    HSD17B11    HSD17B13

    RDH10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RDH10 (see all 547)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs667636361,2
    C--69723574(+) TTTTG-/TTTTTTT 1 -- int10--------
    rs1820084881,2
    --74208016(+) TGCCCC/TGTCCT 1 -- int10--------
    rs1381612221,2
    C,F--74208053(+) CGGCGA/C/GGGGGA 1 -- int11NS 148
    rs774444821,2
    C,F--74208105(+) GGGAAC/ATTGTT 1 -- int13Minor allele frequency- A:0.10WA NS 268
    rs1413075291,2
    C--74208247(+) TAGACA/GAGGGC 1 -- int10--------
    rs1857974741,2
    --74208400(+) TCGTTA/GTAAAT 1 -- int10--------
    rs356809211,2
    C,F--74208422(+) TTTTGG/ATCACC 1 -- int19Minor allele frequency- A:0.42NA WA CSA EA NS 484
    rs1415885621,2
    --74208549(+) TGGCT-/GGTTGG 1 -- int10--------
    rs763332421,2
    F--74208599(+) CTGTAC/TGGAGA 1 -- int11Minor allele frequency- T:0.11WA 118
    rs1467877041,2
    --74208600(+) TGTACA/GGAGAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for RDH10 (74206847 - 74237516 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RDH10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737154CNV Deletion23290073
    nsv891012CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RDH10
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607599    OMIM disorders: --

    8 diseases for RDH10:    
    About MalaCards
    fundus albipunctatus    retinitis    attention deficit hyperactivity disorder    crohn's disease
    meningitis    tuberculosis    multiple sclerosis    lung cancer

    1 disease from the University of Copenhagen DISEASES database for RDH10:
    Fundus albipunctatus

    RDH10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RDH10

    Export disorders for RDH10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RDH10 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with RDH10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. (PubMed id 12407145)1, 2, 3, 9 Wu B.X.... Ma J.-X. (Invest. Ophthalmol. Vis. Sci. 2002)
    2. Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene. (PubMed id 14596915)1, 2, 9 Picozzi P.... Ginelli E. (FEBS Lett. 2003)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Characterization of key residues and membrane association domains in retinol dehydrogenase 10. (PubMed id 19102727)1, 9 Takahashi Y....Ma J.X. (Biochem. J. 2009)
    6. The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. (PubMed id 19458327)1, 9 Farjo K.M....Ma J.X. (amp 2009)
    7. Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenase. (PubMed id 18502750)1, 9 Belyaeva O.V....Kedishvili N.Y. (J. Biol. Chem. 2008)
    8. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    9. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (PLoS Genet. 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 157506 HGNC: 19975 AceView: RDH10 Ensembl:ENSG00000121039 euGenes: HUgn157506
    ECgene: RDH10 Kegg: 157506 H-InvDB: RDH10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RDH10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RDH10 gene:
    Search GeneIP for patents involving RDH10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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