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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RDH10 Gene

protein-coding   GIFtS: 57
GCID: GC08P074207

Retinol Dehydrogenase 10 (All-Trans)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Retinol Dehydrogenase 10 (All-Trans)1 2     Short Chain Dehydrogenase/Reductase Family 16C, Member 42
Member 41     EC 1.1.1.3003
Short Chain Dehydrogenase/Reductase Family 16C1     EC 1.1.18
SDR16C42     EC 1.1.1.n28
Retinol Dehydrogenase 102     

External Ids:    HGNC: 199751   Entrez Gene: 1575062   Ensembl: ENSG000001210397   OMIM: 6075995   UniProtKB: Q8IZV53   

Export aliases for RDH10 gene to outside databases

Previous GC identifers: GC08P074147 GC08P073930 GC08P074257 GC08P074369 GC08P069698


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RDH10 Gene:
This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference
for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic
retinoic acid and is required for limb, craniofacial, and organ development. (provided by RefSeq, Dec 2011)

GeneCards Summary for RDH10 Gene: 
RDH10 (retinol dehydrogenase 10 (all-trans)) is a protein-coding gene. Diseases associated with RDH10 include fundus albipunctatus, and retinitis, and among its related super-pathways are the visual cycle I (vertebrates) and Retinoid metabolism and transport. GO annotations related to this gene include NADP-retinol dehydrogenase activity and nucleotide binding. An important paralog of this gene is HSD17B13.

UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5
Function: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal.
Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RDH10 gene promoter:
         AML1a   Pax-5   FOXO4   Sox9   Pax-4a   HNF-3beta   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RDH10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RDH10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q21.11

RDH10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RDH10 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P074207:  view genomic region     (about GC identifiers)

Start:
74,206,847 bp from pter      End:
74,237,516 bp from pter
Size:
30,670 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5 (See protein sequence)
Recommended Name: Retinol dehydrogenase 10  
Size: 341 amino acids; 38087 Da
Subcellular location: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum
membrane; Single-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for RDH10: NX_Q8IZV5

Explore proteomics data for RDH10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZV5

  • 4/12 DME Specific Peptides for RDH10 (Q8IZV5) (see all 12)
     TTKAFLP  YCASKFGV  VLWAFVLAA  GADKCMYPF 

    RDH10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RDH10 Protein Expression
    REFSEQ proteins: NP_742034.1  
    ENSEMBL proteins: 
     ENSP00000240285   ENSP00000429727   ENSP00000428132  
    Reactome Protein details: Q8IZV5
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    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634NOT nucleus IDA19458327
    GO:0005737cytoplasm IDA19458327
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IDA19458327

    RDH10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SDRC3: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8IZV5

    ProtoNet protein and cluster: Q8IZV5

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    RDH10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RDH10_HUMAN, Q8IZV5
    Function: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal.
    Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol
    Catalytic activity: All-trans-retinol + NADP(+) = all-trans-retinal + NADPH

         Enzyme Numbers (IUBMB): EC 1.1.1.3001 EC 1.1.1.n22 EC 1.1.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004745retinol dehydrogenase activity IDA12407145
    GO:0016491oxidoreductase activity ----
    GO:0052650NADP-retinol dehydrogenase activity IEA--
         
    RDH10 for ontologies           About GeneDecksing


    Phenotypes:
         15/21 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Rdh10) (see all 21):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  homeostasis/metabolism 
     limbs/digits/tail  liver/biliary system  mortality/aging  nervous system  normal 

    RDH10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RDH10: Rdh10tm1d(KOMP)Wtsi Rdh10tm1.1Ics Rdh10tm2Ics

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    SwitchGear 3'UTR luciferase reporter plasmidRDH10 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RDH10 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1the visual cycle I (vertebrates)
    the visual cycle I (vertebrates)0.52
    The canonical retinoid cycle in rods (twilight vision)0.50
    retinol biosynthesis0.52
    2Visual phototransduction
    Visual phototransduction0.48
    Diseases associated with visual transduction0.47
    3Signaling by GPCR
    Signal Transduction0.55
    4Metabolism
    Metabolic pathways0.40
    5Drug metabolism - cytochrome P450
    Retinol metabolism0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RDH10
        Visual Cycle in Retinal Rods

    3 BioSystems Pathways for RDH10
        Vitamin A and carotenoid metabolism
    retinol biosynthesis
    the visual cycle I (vertebrates)

    5        Reactome Pathways for RDH10
        Diseases associated with visual transduction
    Signal Transduction
    The canonical retinoid cycle in rods (twilight vision)
    Visual phototransduction
    Disease


    2         Kegg Pathways  (Kegg details for RDH10):
        Retinol metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5
    Pathway: Cofactor metabolism; retinol metabolism


    RDH10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RDH10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for RDH10 (ENSP000002402854) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    BCMO1ENSP000002581684STRING: ENSP00000258168
    CYP26A1ENSP000002243564STRING: ENSP00000224356
    DGAT1ENSP000003322584STRING: ENSP00000332258
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0001656metanephros development IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0002138retinoic acid biosynthetic process IEA--
    GO:0007601visual perception IDA12407145

    RDH10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RDH10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RDH10

    3 HMDB Compounds for RDH10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glucosylceramide (d18:1/20:0)1-O-b-D-glucopyranosyl-Ceramide (see all 8)85305-87-9--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    2 Novoseek inferred chemical compound relationships for RDH10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin a 77 24 19102727 (3), 12407145 (3), 19141675 (2), 15505029 (2) (see all 8)
    retinoic acid 66.4 8 19141675 (2), 19102727 (1), 19592647 (1), 16982809 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about RDH10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RDH10 gene: 
    NM_172037.4  

    Unigene Cluster for RDH10:

    Retinol dehydrogenase 10 (all-trans)
    Hs.244940  [show with all ESTs]
    Unigene Representative Sequence: NM_172037
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240285(uc003xzi.3 uc003xzj.3) ENST00000518870 ENST00000521928
    ENST00000519380 ENST00000521013
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    Additional mRNA sequence: 

    AF456765.1 AY358270.1 BC067131.1 

    5 DOTS entries:

    DT.103193  DT.95253713  DT.100776423  DT.92420860  DT.99994312 

    24/141 AceView cDNA sequences (see all 141):

    BM993657 BU608508 BU607750 BM979244 CA503115 BM708760 CB134622 AI363760 
    CA393380 CA309760 AA101770 AA366057 AI275729 BE857123 CD677140 AW151393 
    CB158210 BM069775 AA343664 AI627313 BM804062 BM979260 AA135554 CA428638 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RDH10 expression in normal human tissues (normalized intensities)      RDH10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTCAGGA
    RDH10 Expression
    About this image


    RDH10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Fibroblast
             X-gene Foreskin Fibroblasts   
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Autopod
             limb/hindlimb   
     
     Nose (Sensory Organs)    fully expand to see all 4 entries
             sensory organ/nose/nasal cavity   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor ES-139

    See RDH10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RDH10

    SOURCE GeneReport for Unigene cluster: Hs.244940

    UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5
    Tissue specificity: Detected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RDH10 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rdh101 , 5 retinol dehydrogenase 10 (all-trans)1, 5 92.28(n)1
    98.83(a)1
      1 (4.94 cM)5
    987111  NM_133832.31  NP_598593.11 
     161057745 
    chicken
    (Gallus gallus)
    Aves RDH101 retinol dehydrogenase 10 (all-trans) 84.76(n)
    93.22(a)
      420183  NM_001199459.1  NP_001186388.1 
    lizard
    (Anolis carolinensis)
    Reptilia RDH106
    --
    Uncharacterized protein
    91(a)
    50(a)
    1 ↔ 1
    possible ortholog
    4(33475549-33516185)
    4(146455902-146466690)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.243992 Xenopus laevis transcribed sequence with weak similarity more 79.73(n)    CB207153.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rdh102 retinol dehydrogenase 10 78.47(n)   378722  BC054596.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG149466
    CG22546
    (see all 4)
    --
    30(a)
    29(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    2L(12063523-12066772)
    X(7972382-7975635)
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-296
    Protein DHS-29
    20(a)
    possible ortholog
    X(7661902-7664914)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YDL114W6
    TDA56
    Putative protein of unknown function with similari...
    Putative protein of unknown function; detected in ...
    21(a)
    18(a)
    many ↔ many
    many ↔ many
    IV(255604-256530)
    XII(987062-988113)


    ENSEMBL Gene Tree for RDH10 (if available)
    TreeFam Gene Tree for RDH10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RDH10 gene
    HSD17B132  HSD17B112  DHRS32  SDR16C52  
    5 SIMAP similar genes for RDH10 using alignment to 3 protein entries:     RDH10_HUMAN (see all proteins):
    DHRS3    SDR16C5    HPGD    HSD17B11    HSD17B13

    RDH10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/547 SNPs in RDH10 are shown (see all 547)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs667636361,2
    C--69723574(+) TTTTG-/TTTTTTT 1 -- int10--------
    rs1820084881,2
    --74208016(+) TGCCCC/TGTCCT 1 -- int10--------
    rs1381612221,2
    C,F--74208053(+) CGGCGA/C/GGGGGA 1 -- int11NS 148
    rs774444821,2
    C,F--74208105(+) GGGAAC/ATTGTT 1 -- int13Minor allele frequency- A:0.10WA NS 268
    rs1413075291,2
    C--74208247(+) TAGACA/GAGGGC 1 -- int10--------
    rs1857974741,2
    --74208400(+) TCGTTA/GTAAAT 1 -- int10--------
    rs356809211,2
    C,F--74208422(+) TTTTGG/ATCACC 1 -- int19Minor allele frequency- A:0.42NA WA CSA EA NS 484
    rs1415885621,2
    --74208549(+) TGGCT-/GGTTGG 1 -- int10--------
    rs763332421,2
    F--74208599(+) CTGTAC/TGGAGA 1 -- int11Minor allele frequency- T:0.11WA 118
    rs1467877041,2
    --74208600(+) TGTACA/GGAGAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for RDH10 (74206847 - 74237516 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RDH10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737154CNV Deletion23290073
    nsv891012CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607599    OMIM disorders: --

    6 diseases for RDH10:    About MalaCards
    fundus albipunctatus    retinitis    tuberculosis    crohn's disease
    lung cancer    alcoholism

    1 disease from the University of Copenhagen DISEASES database for RDH10:
    Fundus albipunctatus

    RDH10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RDH10

    Export disorders for RDH10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RDH10 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with RDH10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. (PubMed id 12407145)1, 2, 3, 9 Wu B.X.... Ma J.-X. (2002)
    2. Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene. (PubMed id 14596915)1, 2, 9 Picozzi P.... Ginelli E. (2003)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Characterization of key residues and membrane association domains in retinol dehydrogenase 10. (PubMed id 19102727)1, 9 Takahashi Y....Ma J.X. (2009)
    6. The 11-cis-retinol dehydrogenase activity of RDH10 an d its interaction with visual cycle proteins. (PubMed id 19458327)1, 9 Farjo K.M....Ma J.X. (2009)
    7. Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenase. (PubMed id 18502750)1, 9 Belyaeva O.V....Kedishvili N.Y. (2008)
    8. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    9. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 157506 HGNC: 19975 AceView: RDH10 Ensembl:ENSG00000121039 euGenes: HUgn157506
    ECgene: RDH10 Kegg: 157506 H-InvDB: RDH10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RDH10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RDH10 gene:
    Search GeneIP for patents involving RDH10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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