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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RDH10 Gene

protein-coding GIFtS: 55
GCID: GC08P074207

retinol dehydrogenase 10 (all-trans)

Explore 5 diseases affiliated with
RDH10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Retinol Dehydrogenase 10 (All-Trans)¹ ²		EC 1.1.1.300³
SDR16C4¹ ²		EC 1.1.1⁸
Retinol Dehydrogenase 10²		EC 1.1.1.N2¹
Short Chain Dehydrogenase/Reductase Family 16C, Member 4²

External Ids:	HGNC: 19975¹	Entrez Gene: 157506²	Ensembl: ENSG00000121039⁷	OMIM: 607599⁵	UniProtKB: Q8IZV5³

Export aliases for RDH10 gene to outside databases

Previous GC identifers: GC08P074147 GC08P073930 GC08P074257 GC08P074369 GC08P069698

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RDH10:

This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for

NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid

and is required for limb, craniofacial, and organ development. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5

Function: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has

no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008183.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RDH10 gene promoter:
AML1a Pax-5 FOXO4 Sox9 Pax-4a HNF-3beta En-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for RDH10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RDH10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11 Ensembl cytogenetic band: 8q21.11 HGNC cytogenetic band: 8q21.11

RDH10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RDH10 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P074207: view genomic region (about GC identifiers)

Start:	74,206,847 bp from pter	End:	74,237,516 bp from pter
Size:	30,670 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5 (See protein sequence)

Recommended Name: Retinol dehydrogenase 10

Size: 341 amino acids; 38087 Da

Subcellular location: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane;

Single-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for RDH10: NX_Q8IZV5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IZV5

4/12 DME Specific Peptides for RDH10 (Q8IZV5) (see all 12)

TTKAFLP

YCASKFGV

VLWAFVLAA

GADKCMYPF

RDH10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_742034.1

ENSEMBL proteins:

ENSP00000240285 ENSP00000429727 ENSP00000428132

Reactome Protein details: Q8IZV5
Human Recombinant Protein Products for RDH10:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RDH10

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005634	NOT nucleus	IDA	19458327
GO:0005737	cytoplasm	IDA	19458327
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	--	--

RDH10 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RDH10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RDH10 for domains About GeneDecksing

4 InterPro domains/families:

IPR020904 Sc_DH/Rdtase_CS

IPR002347 Glc/ribitol_DH

IPR002198 DH_sc/Rdtase_SDR

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q8IZV5

ProtoNet protein and cluster: Q8IZV5

2 Blocks protein families:

IPB002198 Short-chain dehydrogenase/reductase SDR

IPB002347 Glucose/ribitol dehydrogenase family signature

UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RDH10_HUMAN, Q8IZV5

Function: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has

no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol

Catalytic activity: All-trans-retinol + NADP(+) = all-trans-retinal + NADPH

Enzyme Numbers (IUBMB): EC 1.1.1.300¹ EC 1.1.1.n2² EC 1.1.1²

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004745	retinol dehydrogenase activity	IDA	12407145
GO:0052650	NADP-retinol dehydrogenase activity	IEA	--

RDH10 for ontologies About GeneDecksing

Phenotypes:
15/22 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Rdh10) (see all 22):

behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	homeostasis/metabolism
limbs/digits/tail	liver/biliary system	mortality/aging	nervous system	no phenotypic analysis

RDH10 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for RDH10: Rdh10^{tm1d(KOMP)Wtsi} Rdh10^tm1.1Ics Rdh10^tm2Ics

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RDH10

miRNA Products:		miRTarBase miRNAs that target RDH10: hsa-let-7b (MIRT001600), hsa-mir-124 (MIRT003051)

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		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate RDH10 (see all 62):
		hsa-miR-579 hsa-miR-3607-3p hsa-let-7d hsa-miR-429 hsa-miR-4305 hsa-let-7g hsa-miR-374c hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: RDH10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: RDH10 (NM_172037)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RDH10

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

the visual cycle I (vertebrates)

	the visual cycle I (vertebrates)	1.00			The canonical retinoid cycle in rods (twilight vision)	0.50
	retinol biosynthesis	0.52

Retinoid metabolism and transport

Visual phototransduction

0.74

Diseases associated with visual transduction

0.73

Disease

Disease

1.00

Visual Cycle in Retinal Rods

Visual Cycle in Retinal Rods

1.00

Vitamin A and carotenoid metabolism

Vitamin A and carotenoid metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RDH10

Visual Cycle in Retinal Rods

3 BioSystems Pathways for RDH10

	Vitamin A and carotenoid metabolism
	the visual cycle I (vertebrates)
	retinol biosynthesis

5 Reactome Pathways for RDH10

	Diseases associated with visual transduction
	Signal Transduction
	The canonical retinoid cycle in rods (twilight vision)
	Visual phototransduction
	Disease

2 Kegg Pathways (Kegg details for RDH10):

	Retinol metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5

Pathway: Cofactor metabolism; retinol metabolism

RDH10 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RDH10

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/12 Interacting proteins for RDH10 (ENSP00000240285⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALDH1A1	ENSP00000297785⁴	STRING: ENSP00000297785
ALDH1A2	ENSP00000249750⁴	STRING: ENSP00000249750
BCMO1	ENSP00000258168⁴	STRING: ENSP00000258168
CYP26A1	ENSP00000224356⁴	STRING: ENSP00000224356
DGAT1	ENSP00000332258⁴	STRING: ENSP00000332258

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001656	metanephros development	IEA	--
GO:0001701	in utero embryonic development	IEA	--
GO:0002138	retinoic acid biosynthetic process	IEA	--
GO:0007601	visual perception	IDA	12407145
GO:0008406	gonad development	IEA	--

RDH10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RDH10 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RDH10

3 HMDB Compounds for RDH10 About this table

Compound	Synonyms	CAS #	PubMed Ids
Glucosylceramide (d18:1/20:0)	1-O-b-D-glucopyranosyl-Ceramide (see all 8)	85305-87-9	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--

2 Novoseek chemical compound relationships for RDH10 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vitamin a	77	24	19102727 (3), 12407145 (3), 19141675 (2), 15505029 (2) (see all 8)
retinoic acid	66.4	8	19141675 (2), 19102727 (1), 19592647 (1), 16982809 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about RDH10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RDH10 gene:

NM_172037.4

Unigene Cluster for RDH10:

Retinol dehydrogenase 10 (all-trans)

Hs.244940 [show with all ESTs]

Unigene Representative Sequence: NM_172037

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000240285(uc003xzi.3 uc003xzj.3) ENST00000518870 ENST00000521928

ENST00000519380 ENST00000521013

miRNA Products:		OriGene 3'-UTR Clone: RDH10 Browse OriGene MicroRNA Expression Plasmids
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		hsa-miR-579 hsa-miR-3607-3p hsa-let-7d hsa-miR-429 hsa-miR-4305 hsa-let-7g hsa-miR-374c hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: RDH10 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RDH10

Additional cDNA sequence:

AF456765.1 AY358270.1 BC067131.1

5 DOTS entries:

DT.103193 DT.95253713 DT.100776423 DT.92420860 DT.99994312

24/141 AceView cDNA sequences (see all 141):

AI335680 AI686376 AI275729 AW301249 BM993657 AW151393 CD677140 BM979260

CB158210 CA393380 AI095886 BM988653 CB134622 BU608508 BU607750 CA503115

CN483597 CK904750 BM726396 AA873846 BE857123 AI627313 BM069775 AI150994

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RDH10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGTCAGGA

About this image

RDH10 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Anterior Meninges

Meningeal Cells

Meninges

Kidney

Limb

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

See RDH10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RDH10

SOURCE GeneReport for Unigene cluster: Hs.244940

UniProtKB/Swiss-Prot: RDH10_HUMAN, Q8IZV5

Tissue specificity: Detected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle

SABiosciences Custom PCR Arrays for RDH10

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RDH10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RDH10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RDH10 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RDH10¹	retinol dehydrogenase 10 (all-trans)	84.76(n) 93.22(a)		420183 NM_001199459.1 NP_001186388.1
lizard (Anolis carolinensis)	Reptilia	RDH10⁶	--	90(a)	1 ↔ 1	4(33479500-33514958)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24399²	Xenopus laevis transcribed sequence with weak similarity more	79.73(n)		CB207153.1
zebrafish (Danio rerio)	Actinopterygii	rdh10²	retinol dehydrogenase 10	78.47(n)		378722 BC054596.1
fruit fly (Drosophila melanogaster)	Insecta	CG14946⁶ CG2254⁶ (see all 4)	--	31(a) 30(a) (see all 4)	possible ortholog possible ortholog (see all 4)	2L(12063523-12066772) X(7972382-7975635)
worm (Caenorhabditis elegans)	Secernentea	dhs-29⁶	DeHydrogenases, Short chain family member (dhs-29)...	19(a)	possible ortholog	X(7661851-7664863)

ENSEMBL Gene Tree for RDH10 (if available)
TreeFam Gene Tree for RDH10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RDH10 gene

HSD17B13² HSD17B11² DHRS3² SDR16C5²

5 SIMAP similar genes for RDH10 using alignment to 3 protein entries: RDH10_HUMAN (see all proteins):

DHRS3 SDR16C5 HPGD HSD17B11 HSD17B13

RDH10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182008488^1,2		--	74208016(+)	`TGCCCC/TGTCCT`	1	--	int¹		0	--	--	--	--
rs138161222^1,2	C,F	--	74208053(+)	`CGGCGA/C/GGGGGA`	1	--	int¹		1		NS	148
rs77444482^1,2	C	--	74208105(+)	`GGGAAC/ATTGTT`	1	--	int¹		3		WA NS	268
rs141307529^1,2		--	74208247(+)	`TAGACA/GAGGGC`	1	--	int¹		0	--	--	--	--
rs185797474^1,2		--	74208400(+)	`TCGTTA/GTAAAT`	1	--	int¹		0	--	--	--	--
rs35680921^1,2	C,F	--	74208422(+)	`TTTTGG/ATCACC`	1	--	int¹		9		NA WA CSA EA NS	484
rs141588562^1,2		--	74208549(+)	`TGGCT-/GGTTGG`	1	--	int¹		0	--	--	--	--
rs76333242^1,2	F	--	74208599(+)	`CTGTAC/TGGAGA`	1	--	int¹		1		WA	118
rs146787704^1,2		--	74208600(+)	`TGTACA/GGAGAA`	1	--	int¹		0	--	--	--	--
rs140580813^1,2		--	74208748(+)	`CCTGCC/TGAAAC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RDH10 (74206847 - 74237516 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RDH10: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RDH10 for disorders           About GeneDecksing

OMIM gene information: 607599    OMIM disorders: --

5 diseases for RDH10:    About MalaCards

fundus albipunctatus retinitis lung cancer tuberculosis

mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for RDH10:

Fundus albipunctatus

Export disorders for RDH10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RDH10 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with RDH10)

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world of online information

Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. (PubMed id 12407145)^{1, 2, 3, 9} Wu B.X.... Ma J.-X. (2002)
Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene. (PubMed id 14596915)^{1, 2, 9} Picozzi P.... Ginelli E. (2003)
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)^{1, 3} Persson B.... Oppermann U. (2009)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Characterization of key residues and membrane association domains in retinol dehydrogenase 10. (PubMed id 19102727)^{1, 9} Takahashi Y....Ma J.X. (2009)
The 11-cis-retinol dehydrogenase activity of RDH10 an d its interaction with visual cycle proteins. (PubMed id 19458327)^{1, 9} Farjo K.M....Ma J.X. (2009)
Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenase. (PubMed id 18502750)^{1, 9} Belyaeva O.V....Kedishvili N.Y. (2008)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)¹ Kenny E.E....Peter I. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 157506	HGNC: 19975	AceView: RDH10	Ensembl:ENSG00000121039	euGenes: HUgn157506
ECgene: RDH10	Kegg: 157506	H-InvDB: RDH10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RDH10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RDH10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RDH10 gene:
Search GeneIP for patents involving RDH10

GeneCards and IP:
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retinol dehydrogenase 10 (all-trans)

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RDH10 Gene

retinol dehydrogenase 10 (all-trans)

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