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Aliases for RD3L Gene

Aliases for RD3L Gene

  • Retinal Degeneration 3-Like 2 3 5
  • Retinal Degeneration Protein 3-Like 3 4
  • TDRD9 Antisense 1 2 3
  • TDRD9 Antisense RNA 1 (Non-Protein Coding) 3
  • Protein RD3-Like 3
  • TDRD9-AS1 3
  • TDRD9AS1 3

External Ids for RD3L Gene

Previous HGNC Symbols for RD3L Gene

  • TDRD9-AS1

Previous GeneCards Identifiers for RD3L Gene

  • GC14M104410

Summaries for RD3L Gene

GeneCards Summary for RD3L Gene

RD3L (Retinal Degeneration 3-Like) is a Protein Coding gene. An important paralog of this gene is RD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RD3L Gene

Genomics for RD3L Gene

Regulatory Elements for RD3L Gene

Enhancers for RD3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F103108 1 FANTOM5 ENCODE 5.2 +831.3 831316 5.7 HDGF PKNOX1 SIN3A FEZF1 YY1 GLIS2 FOS PAF1 ZNF263 MCM3 TNFAIP2 ENSG00000259444 TRAF3 RD3L EIF5 MARK3 BAG5 APOPT1 GC14M103075
GH14F103943 0.6 ENCODE 0.8 -1.6 -1621 0.8 LEF1 PKNOX1 ATF1 TBL1XR1 TAL1 NFRKB ZNF175 ZNF644 ZNF316 FOXK2 TDRD9 C14orf2 ASPG RD3L GC14P103968
GH14F103931 1.1 FANTOM5 Ensembl ENCODE 0.4 +9.6 9608 3.4 SOX13 ELF3 CTCF PKNOX1 SAP130 ZNF133 RAD21 RARA ZNF7 TEAD3 TDRD9 C14orf2 ENSG00000202275 RD3L
GH14F103949 0.2 Ensembl 0.4 -7.5 -7493 0.4 TDRD9 C14orf2 RD3L GC14P103968
GH14F103929 0.2 Ensembl 0.4 +12.2 12208 0.6 ZNF687 ESRRA PKNOX1 DPF2 RARA GATA3 CTBP1 FOS ZNF548 XRCC3 TDRD9 RD3L
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RD3L on UCSC Golden Path with GeneCards custom track

Genomic Location for RD3L Gene

103,940,426 bp from pter
103,942,308 bp from pter
1,883 bases
Minus strand

Genomic View for RD3L Gene

Genes around RD3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RD3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RD3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RD3L Gene

Proteins for RD3L Gene

  • Protein details for RD3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein RD3-like
    Protein Accession:

    Protein attributes for RD3L Gene

    198 amino acids
    Molecular mass:
    23209 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RD3L Gene

Post-translational modifications for RD3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RD3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RD3L Gene

Domains & Families for RD3L Gene

Protein Domains for RD3L Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RD3L: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RD3L Gene

Function for RD3L Gene

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RD3L Gene

Localization for RD3L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RD3L Gene

Pathways & Interactions for RD3L Gene

SuperPathways for RD3L Gene

No Data Available

Interacting Proteins for RD3L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000455434 P0DJH9-RD3L_HUMAN for RD3L Gene via STRING IID

Gene Ontology (GO) - Biological Process for RD3L Gene


No data available for Pathways by source and SIGNOR curated interactions for RD3L Gene

Transcripts for RD3L Gene

mRNA/cDNA for RD3L Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RD3L Gene

Retinal degeneration 3-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RD3L Gene

No ASD Table

Relevant External Links for RD3L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RD3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RD3L Gene

mRNA differential expression in normal tissues according to GTEx for RD3L Gene

This gene is overexpressed in Heart - Left Ventricle (x31.9) and Heart - Atrial Appendage (x17.5).

Protein differential expression in normal tissues from HIPED for RD3L Gene

This gene is overexpressed in Bone (47.5) and Testis (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RD3L Gene

Protein tissue co-expression partners for RD3L Gene

NURSA nuclear receptor signaling pathways regulating expression of RD3L Gene:


SOURCE GeneReport for Unigene cluster for RD3L Gene:

genes like me logo Genes that share expression patterns with RD3L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RD3L Gene

Orthologs for RD3L Gene

This gene was present in the common ancestor of chordates.

Orthologs for RD3L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RD3L 34
  • 99.66 (n)
(Canis familiaris)
Mammalia RD3L 34 35
  • 89.06 (n)
(Bos Taurus)
Mammalia RD3L 34 35
  • 84.85 (n)
(Mus musculus)
Mammalia BC048943 34 35
  • 81.39 (n)
Rd3l 16
(Rattus norvegicus)
Mammalia RGD1305627 34
  • 81.27 (n)
(Ornithorhynchus anatinus)
Mammalia RD3L 35
  • 79 (a)
(Monodelphis domestica)
Mammalia RD3L 35
  • 75 (a)
(Gallus gallus)
Aves RD3L 35
  • 75 (a)
LOC772190 34
  • 74.92 (n)
(Anolis carolinensis)
Reptilia RD3L 35
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rd3l 34
  • 69.08 (n)
(Danio rerio)
Actinopterygii si:ch211-253p18.5 34
  • 49.47 (n)
RD3L 35
  • 30 (a)
Species where no ortholog for RD3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RD3L Gene

Gene Tree for RD3L (if available)
Gene Tree for RD3L (if available)

Paralogs for RD3L Gene

Paralogs for RD3L Gene

genes like me logo Genes that share paralogs with RD3L: view

Variants for RD3L Gene

Sequence variations from dbSNP and Humsavar for RD3L Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs111741528 -- 103,941,475(+) CTGGG(A/G)TAGTT intron-variant, reference, missense
rs112530093 -- 103,944,174(+) CTCAC(A/G)TTATC intron-variant, upstream-variant-2KB
rs116710917 -- 103,943,731(+) TGTGA(A/G)ACGAC intron-variant, upstream-variant-2KB
rs116853391 -- 103,942,940(+) TATGG(C/T)AATAA intron-variant, upstream-variant-2KB
rs117542394 -- 103,944,198(+) CCTCT(A/G)CAGTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RD3L Gene

Variant ID Type Subtype PubMed ID
esv2760013 CNV loss 17122850
nsv1054574 CNV loss 25217958

Variation tolerance for RD3L Gene

Gene Damage Index Score: 5.17; 69.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RD3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RD3L Gene

Disorders for RD3L Gene

Relevant External Links for RD3L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RD3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RD3L Gene

Publications for RD3L Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 64
  2. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for RD3L Gene

Sources for RD3L Gene

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