RCVRN Gene

Aliases
for RCVRN gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifer: GC17M009742

Summaries
for RCVRN gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for RCVRN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000017.10  NC_018928.2  NT_010718.17  

SwitchGear Promoter luciferase reporter plasmid: RCVRN promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RCVRN

RCVRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M009799:  view genomic region     (about GC identifiers)

Proteins
for RCVRN gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for RCVRN:

2D8N (3D)    

Explore the universe of human proteins at neXtProt for RCVRN: NX_P35243

Explore proteomics data for RCVRN at MOPED


See RCVRN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

RCVRN Human Recombinant Protein Products:

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	antibodies-online proteins for RCVRN (28 products)
	antibodies-online peptides for RCVRN

RCVRN Antibody Products:

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RCVRN Assay Products:

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	antibodies-online kits for RCVRN (8 products)

Domains /
Families
for RCVRN gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P35243

Find genes that share domains with RCVRN           About GenesLikeMe

Function
for RCVRN gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Rcvrn)

genOway: Develop your customized and physiologically relevant rodent model for RCVRN

miRNA Products:		miRTarBase miRNAs that target RCVRN: hsa-mir-335-5p (MIRT017646)
		Block miRNA regulation of human, mouse, rat RCVRN using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate RCVRN (see all 10):
		hsa-miR-3130-5p hsa-miR-3117-3p hsa-miR-3139 hsa-miR-500a hsa-miR-4267 hsa-miR-1912 hsa-miR-27b* hsa-miR-708
		SwitchGear 3'UTR luciferase reporter plasmid: RCVRN 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RCVRN
		Predesigned siRNA for gene silencing in human, mouse, rat RCVRN

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for RCVRN

Clone Products:		OriGene clones in human, mouse for RCVRN (see all 5) OriGene ORF clones in mouse, rat for RCVRN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RCVRN (NM_002903)
		Sino Biological Human cDNA Clone for RCVRN
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCVRN

Localization
for RCVRN gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	3
cytoskeleton	2
mitochondrion	2
nucleus	2
peroxisome	1
plasma membrane	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for RCVRN gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for RCVRN About     See pathways by source

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	SuperPath	Contained pathways About
1	The phototransduction cascade	The phototransduction cascade 0.51 Inactivation, recovery and regulation of the phototransduction cascade 0.49 Phototransduction 0.51
2	Diseases associated with visual transduction	Visual phototransduction 0.44 Diseases associated with visual transduction 0.43
3	Signaling by GPCR	Signal Transduction 0.58
4	Disease	Disease

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RCVRN

Visual Cycle in Retinal Rods

1 Reactome Pathway for RCVRN

Inactivation, recovery and regulation of the phototransduction cascade

1 Kegg Pathway  (Kegg details for RCVRN)

Phototransduction

Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

Drugs & Compounds
for RCVRN gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for RCVRN gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for RCVRN gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RCVRN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCCCTGTGCT

About this image

Eye (Sensory Organs)    fully expand to see all 11 entries
Mature Rod Cells Outer Nuclear Layer
Optic cup structures
Human Lens Epithelial Cells (HLEpiC)
NULL (Sensory Organs)    fully expand to see all 6 entries
Retina-like cells
Neurons
Mature Rod Cells Outer Nuclear Layer
Epithelial Cells (Uncategorized)    fully expand to see all 2 entries
Human Lens Epithelial Cells (HLEpiC)

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCVRN

Orthologs
for RCVRN gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for RCVRN gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for RCVRN gene

HPCA²  KCNIP3²  KCNIP4²  KCNIP1²  GUCA1A²  HPCAL1²  GUCA1B²  NCALD²  

KCNIP2²  HPCAL4²  NCS1²  GUCA1C²  VSNL1²  

15 SIMAP similar genes for RCVRN using alignment to 1 protein entry:     RECO_HUMAN:

DKFZp781K1922    HPCAL1    NCALD    HPCA    VSNL1    HPCAL4

KCNIP2    NCS1    KCNIP3    KCNIP1    KCNIP4    GUCA1A

GUCA1B    DKFZp686E1183    GUCA1C

Find genes that share paralogs with RCVRN           About GenesLikeMe

Genomic Variants
for RCVRN gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RCVRN (see all 309)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1499947411,2		--	9711021(+)	CGAGAA/GGTTCA	1	--	us2k1		0	--	--	--	--
rs1442798901,2		--	9711043(+)	GCAGAC/TTCATC	1	--	us2k1		0	--	--	--	--
rs744767841,2	C,F	--	9800529(+)	CTTTGC/TGTGGT	1	--	ds5001		3		NA	124
rs604173661,2	C,F	--	9800530(+)	TTTGCG/TTGGTC	1	--	ds5001		2		WA	120
rs1177757121,2	C,F	--	9800585(+)	CTCCTC/ACTTCT	1	--	ds5001		1		NA	120
rs728222011,2	C,F	--	9800658(+)	TGTGTT/GGGCCG	1	--	ds5001		1		NA	120
rs80761851,2	C,F	--	9800698(+)	CCCGTC/G/TCCCCG	1	--	ds5001		4		NA WA	242
rs620644851,2	C,F	--	9800717(+)	GCAGTG/CGTTCT	1	--	ds5001		3		NA	124
rs1443231191,2	C	--	9800731(+)	TTTAA-/ATCTCCC TTCGTCAGGGATGTG	1	--	ds5001		0	--	--	--	--
rs620644861,2		--	9800735(+)	AATCTG/CCCTTC	1	--	ds5001		1		NA	2

HapMap Linkage Disequilibrium report for RCVRN (9799637 - 9808938 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for RCVRN:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv516119	CNV	Loss	19592680
nsv833360	CNV	Loss	17160897
dgv38n68	CNV	Loss	17160897
nsv833361	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RCVRN

DNA2.0 Custom Variant and Variant Library Synthesis for RCVRN

Disorders / Diseases
for RCVRN gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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4 diseases for RCVRN

Selected Novoseek inferred disease relationships for RCVRN gene (see all 28)    About this table

Publications
for RCVRN gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Isolation of human retinal genes: recoverin cDNA and gene. (PubMed id 1387789)^{1, 2, 3, 9} Murakami A.... Inana G. (Biochem. Biophys. Res. Commun. 1992)
2. Recoverin in pineal organs and retinae of various vertebrate species including man. (PubMed id 1467959)^{1, 3, 9} Korf H.W....Klein D.C. (Brain Res. 1992)
3. Expression of a photoreceptor protein, recoverin, as a cancer- associated retinopathy autoantigen in human lung cancer cell lines. (PubMed id 8912538)^{1, 2, 9} Matsubara S.... Takahara J. (Br. J. Cancer 1996)
4. Molecular cloning and nucleotide sequence of a cDNA encoding recoverin from human retina. (PubMed id 8500558)^{1, 2, 9} Wiechmann A.F. and Hammarback J.A. (Exp. Eye Res. 1993)
5. Aberrantly expressed recoverin is functionally associated with G-protein-coupled receptor kinases in cancer cell lines. (PubMed id 12507501)^{1, 3, 9} Miyagawa Y....Nakazawa M. (Biochem. Biophys. Res. Commun. 2003)
6. Functional analysis of the human recoverin gene promoter. (PubMed id 12789533)^{1, 3, 9} Wiechmann A. and Howard E. (Curr. Eye Res. 2003)
7. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)^{1, 2} Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
9. The cancer-associated retinopathy antigen is a recoverin-like protein. (PubMed id 1388144)^{1, 2} Thirkill C.E.... Keltner J.L. (Invest. Ophthalmol. Vis. Sci. 1992)
10. A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy. (PubMed id 1999465)^{1, 2} Polans A.S.... Palczewski K. (J. Cell Biol. 1991)

External Searches for RCVRN gene

Genome Databases showing RCVRN gene

Other Databases showing RCVRN gene

Specialized Databases showing RCVRN gene

Products
for RCVRN gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section