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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCVRN Gene

protein-coding   GIFtS: 60
GCID: GC17M009799

Recoverin


(Previous symbol: RCV1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
recoverin1 2
RCV11 2 3 5
Cancer-Associated Retinopathy Protein2 3
Cancer Associated Retinopathy Antigen2
Protein CAR3

External Ids:    HGNC: 99371   Entrez Gene: 59572   Ensembl: ENSG000001090477   OMIM: 1796185   UniProtKB: P352433   

Export aliases for RCVRN gene to outside databases

Previous GC identifer: GC17M009742


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RCVRN Gene:
This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three
calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by
blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for
cancer-associated retinopathy. (provided by RefSeq, Jul 2008)

GeneCards Summary for RCVRN Gene: 
RCVRN (recoverin) is a protein-coding gene. Diseases associated with RCVRN include cancer-associated retinopathy, and paraneoplastic syndromes, and among its related super-pathways are Visual signal transduction- Rods and Retinoid metabolism and transport. GO annotations related to this gene include calcium sensitive guanylate cyclase activator activity and calcium ion binding. An important paralog of this gene is HPCA.

UniProtKB/Swiss-Prot: RECO_HUMAN, P35243
Function: Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved
in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin
prolongs the photoresponse




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCVRN gene promoter:
         MyoD   GATA-1   RORalpha1   Ik-2   FOXJ2 (long isoform)   c-Myb   ARP-1   Pax-4a   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRCVRN promoter sequence
   Search SABiosciences Chromatin IP Primers for RCVRN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCVRN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

RCVRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCVRN gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M009799:  view genomic region     (about GC identifiers)

Start:
9,799,637 bp from pter      End:
9,808,938 bp from pter
Size:
9,302 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RECO_HUMAN, P35243 (See protein sequence)
Recommended Name: Recoverin  
Size: 200 amino acids; 23130 Da
Miscellaneous: Binds two calcium ions; one with high affinity, the other with low affinity
1 PDB 3D structure from and Proteopedia for RCVRN:
2D8N (3D)    

Explore the universe of human proteins at neXtProt for RCVRN: NX_P35243

Explore proteomics data for RCVRN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35243

  • RCVRN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RCVRN Protein Expression
    REFSEQ proteins: NP_002894.1  
    ENSEMBL proteins: 
     ENSP00000226193   ENSP00000463441  
    Reactome Protein details: P35243
    Human Recombinant Protein Products for RCVRN: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR001125 Recoverin
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P35243

    ProtoNet protein and cluster: P35243

    1 Blocks protein domain: IPB001125 Recoverin family signature

    UniProtKB/Swiss-Prot: RECO_HUMAN, P35243
    Similarity: Belongs to the recoverin family
    Similarity: Contains 4 EF-hand domains


    RCVRN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RECO_HUMAN, P35243
    Function: Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved
    in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin
    prolongs the photoresponse

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0008048calcium sensitive guanylate cyclase activator activity TAS1672047
         
    RCVRN for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RCVRN:
     Decreased circadian period len  Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rcvrn):
     vision/eye 

    RCVRN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rcvrntm1Clma for RCVRN

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RCVRN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RCVRN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RCVRN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RCVRN 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidRCVRN 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RCVRN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Visual signal transduction- Rods
    The phototransduction cascade0.54
    Phototransduction0.46
    Inactivation, recovery and regulation of the phototransduction cascade0.51
    2Visual phototransduction
    Visual phototransduction0.48
    Diseases associated with visual transduction0.47
    3Signaling by GPCR
    Signal Transduction0.55
    4Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/6        Reactome Pathways for RCVRN (see all 6)
        Diseases associated with visual transduction
    The phototransduction cascade
    Signal Transduction
    Visual phototransduction
    Disease


    1         Kegg Pathway  (Kegg details for RCVRN):
        Phototransduction


    RCVRN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RCVRN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/14 Interacting proteins for RCVRN (P352432, 3 ENSP000002261934) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PQBP1O608282, 3, ENSP000003657474MINT-2862654 I2D: score=3 STRING: ENSP00000365747
    CAV1Q031353, ENSP000003391914I2D: score=3 STRING: ENSP00000339191
    GRK6P432503, ENSP000003772044I2D: score=3 STRING: ENSP00000377204
    GRK1Q158353, ENSP000003348764I2D: score=2 STRING: ENSP00000334876
    ADRBK1P250983, ENSP000003122624I2D: score=2 STRING: ENSP00000312262
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS1672047
    GO:0007601visual perception IEA--
    GO:0007602phototransduction ----
    GO:0007603phototransduction, visible light TAS--
    GO:0016056rhodopsin mediated signaling pathway TAS--

    RCVRN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RCVRN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCVRN (RECO)

    1 HMDB Compound for RCVRN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for RCVRN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MYRISTIC ACID-- --target--10592235

    10/11 Novoseek inferred chemical compound relationships for RCVRN gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 62.9 14 1672047 (3), 8961484 (1), 1422899 (1), 7678445 (1) (see all 11)
    calcium 59.4 213 11980481 (7), 7876221 (7), 9392525 (6), 9315839 (5) (see all 65)
    cgmp 47.8 7 1422899 (1), 7678445 (1), 8500558 (1), 18184973 (1) (see all 6)
    myristic acid 34.3 4 16376289 (3)
    retinoic acid 16.4 1 19671662 (1)
    phospholipid 11.4 5 9315839 (2), 12023256 (1), 12767213 (1), 9759500 (1)
    butyrate 1.88 4 8666979 (2), 15301870 (1)
    fatty acid 1.49 3 11980481 (1), 10625670 (1), 7797536 (1)
    lipid 0 11 18034895 (4), 11087403 (2), 12023256 (1), 12767213 (1) (see all 7)
    potassium 0 6 18458082 (1), 17962406 (1), 11535596 (1), 10483569 (1)

    Search CenterWatch for drugs/clinical trials and news about RCVRN / RECO

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RCVRN gene: 
    NM_002903.2  

    Unigene Cluster for RCVRN:

    Recoverin
    Hs.80539  [show with all ESTs]
    Unigene Representative Sequence: NM_002903
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226193(uc002gme.1) ENST00000570909

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    Additional mRNA sequence: 

    AB001838.1 AB593156.1 AK314129.1 BC001720.1 BT009838.1 DQ980605.1 DQ980606.1 DQ980608.1 
    DQ980609.1 S43855.1 S45545.1 S62028.1 

    4 DOTS entries:

    DT.317113  DT.120914699  DT.97759914  DT.95080229 

    24/139 AceView cDNA sequences (see all 139):

    BQ638070 BQ637550 H30195 BQ638143 H30278 NM_002903 H84778 BQ639095 
    BQ639701 AA364705 BM671451 BU154132 H87782 BQ640206 BU726857 BU732239 
    BM709178 BM662530 BQ637103 BM709685 BQ635973 BQ639286 BQ635856 BM709331 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCVRN expression in normal human tissues (normalized intensities)      RCVRN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTGTGCT
    RCVRN Expression
    About this image


    RCVRN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Mature Rod Cells Outer Nuclear Layer
             Human Lens Epithelial Cells (HLEpiC)   
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             Human Lens Epithelial Cells (HLEpiC)   

    See RCVRN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCVRN

    SOURCE GeneReport for Unigene cluster: Hs.80539

    UniProtKB/Swiss-Prot: RECO_HUMAN, P35243
    Tissue specificity: Retina and pineal gland

        SABiosciences Expression via Pathway-Focused PCR Arrays including RCVRN: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCVRN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RCVRN gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rcvrn1 , 5 recoverin1, 5 87.71(n)1
    88.89(a)1
      11 (41.13 cM)5
    196741  NM_009038.21  NP_033064.11 
     676953265 
    lizard
    (Anolis carolinensis)
    Reptilia RCVRN6
    Uncharacterized protein
    69(a)
    1 ↔ 1
    GL343279.1(1369085-1381463)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.263442 Xenopus laevis transcribed sequence with weak similarity more 75.41(n)    CD328078.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk53a032 wufk53a03 72.05(n)   335650  BC059485.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG76466
    --
    38(a)
    1 ↔ 1
    3L(19984987-19989012)
    worm
    (Caenorhabditis elegans)
    Secernentea ncs-26
    Neuronal calcium sensor 2
    45(a)
    1 ↔ 1
    I(10033543-10034824)


    ENSEMBL Gene Tree for RCVRN (if available)
    TreeFam Gene Tree for RCVRN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RCVRN gene
    HPCA2  KCNIP32  KCNIP42  KCNIP12  GUCA1A2  HPCAL12  GUCA1B2  NCALD2  
    KCNIP22  HPCAL42  NCS12  GUCA1C2  VSNL12  
    15 SIMAP similar genes for RCVRN using alignment to 3 protein entries:     RECO_HUMAN (see all proteins):
    DKFZp781K1922    HPCAL1    NCALD    HPCA    VSNL1    HPCAL4
    KCNIP2    NCS1    KCNIP3    KCNIP4    GUCA1A    GUCA1B
    DKFZp686E1183    KCNIP1    GUCA1C

    RCVRN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/309 SNPs in RCVRN are shown (see all 309)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1499947411,2
    --9711021(+) CGAGAA/GGTTCA 1 -- us2k10--------
    rs1442798901,2
    --9711043(+) GCAGAC/TTCATC 1 -- us2k10--------
    rs744767841,2
    C,F--9800529(+) CTTTGC/TGTGGT 1 -- ds50013Minor allele frequency- T:0.25NA 124
    rs604173661,2
    C,F--9800530(+) TTTGCG/TTGGTC 1 -- ds50012Minor allele frequency- T:0.04WA 120
    rs1177757121,2
    C,F--9800585(+) CTCCTC/ACTTCT 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs728222011,2
    C,F--9800658(+) TGTGTT/GGGCCG 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs80761851,2
    C,F--9800698(+) CCCGTC/G/TCCCCG 1 -- ds50014NA WA 242
    rs620644851,2
    C,F--9800717(+) GCAGTG/CGTTCT 1 -- ds50013Minor allele frequency- C:0.28NA 124
    rs1443231191,2
    C--9800731(+) TTTAA-/ATCTCCC
    TTCGTCAGGG
    ATGTG
    1 -- ds50010--------
    rs620644861,2
    --9800735(+) AATCTG/CCCTTC 1 -- ds50011Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for RCVRN (9799637 - 9808938 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RCVRN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv516119CNV Loss19592680
    nsv833360CNV Loss17160897
    dgv38n68CNV Loss17160897
    nsv833361CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179618    OMIM disorders: --

    20 diseases for RCVRN:    About MalaCards
    cancer-associated retinopathy    paraneoplastic syndromes    optic neuritis    neuritis
    uveitis    choroiditis    retinal degeneration    thymoma
    retinoblastoma    retinitis pigmentosa    blindness    lung cancer
    sarcoidosis    retinitis    malignant glioma    neuronitis
    gastric cancer    alzheimer's disease    endotheliitis    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for RCVRN:
    Retinal degeneration

    RCVRN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/28 Novoseek inferred disease relationships for RCVRN gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinopathy 81.2 58 9727517 (3), 7568096 (3), 8892098 (2), 11180121 (2) (see all 40)
    paraneoplastic syndromes 79.8 11 11180121 (2), 16444517 (2), 12507501 (1), 15153841 (1) (see all 8)
    retinal degeneration 74 6 9727517 (2), 12507501 (1), 11074809 (1), 12935781 (1) (see all 5)
    retinitis pigmentosa 61.8 8 16934219 (4), 7906682 (2), 7607661 (1), 9071225 (1)
    small cell lung cancer 49.6 8 15301870 (2), 11557119 (1), 10740224 (1), 10766180 (1) (see all 7)
    visual loss 48.6 2 8912538 (1), 8794409 (1)
    blindness 37.4 2 9040460 (1)
    lung carcinoma 34.2 2 15065647 (1), 12838519 (1)
    adenocarcinoma lung 30.8 5 10766180 (2), 11222531 (1)
    carcinoma non-small cell lung 29.2 2 15301870 (1), 15084384 (1)


    Export disorders for RCVRN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCVRN gene, integrated from 9 sources (see all 214):
    (articles sorted by number of sources associating them with RCVRN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of human retinal genes: recoverin cDNA and gene. (PubMed id 1387789)1, 2, 3, 9 Murakami A.... Inana G. (1992)
    2. Recoverin in pineal organs and retinae of various vertebrate species including man. (PubMed id 1467959)1, 3, 9 Korf H.W....Klein D.C. (1992)
    3. Expression of a photoreceptor protein, recoverin, as a cancer- associated retinopathy autoantigen in human lung cancer cell lines. (PubMed id 8912538)1, 2, 9 Matsubara S.... Takahara J. (1996)
    4. Molecular cloning and nucleotide sequence of a cDNA encoding recoverin from human retina. (PubMed id 8500558)1, 2, 9 Wiechmann A.F. and Hammarback J.A. (1993)
    5. Aberrantly expressed recoverin is functionally associated with G-protein-coupled receptor kinases in cancer cell lines. (PubMed id 12507501)1, 3, 9 Miyagawa Y....Nakazawa M. (2003)
    6. Functional analysis of the human recoverin gene promoter. (PubMed id 12789533)1, 3, 9 Wiechmann A. and Howard E. (2003)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The cancer-associated retinopathy antigen is a recoverin-like protein. (PubMed id 1388144)1, 2 Thirkill C.E.... Keltner J.L. (1992)
    9. A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy. (PubMed id 1999465)1, 2 Polans A.S.... Palczewski K. (1991)
    10. Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin. (PubMed id 18266817)1, 9 Torisawa A....Kawamura S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5957 HGNC: 9937 AceView: RCV1 Ensembl:ENSG00000109047 euGenes: HUgn5957
    ECgene: RCVRN Kegg: 5957 H-InvDB: RCVRN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCVRN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RCVRN gene:
    Search GeneIP for patents involving RCVRN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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