Aliases for RCVRN Gene
Aliases for RCVRN Gene
External Ids for RCVRN Gene
- HGNC: 9937
- Entrez Gene: 5957
- Ensembl: ENSG00000109047
- OMIM: 179618
- UniProtKB: P35243
Previous HGNC Symbols for RCVRN Gene
- RCV1
Previous GeneCards Identifiers for RCVRN Gene
- GC17M009742
- GC17M009799
Summaries for RCVRN Gene
-
This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]
GeneCards Summary for RCVRN Gene
RCVRN (Recoverin) is a Protein Coding gene. Diseases associated with RCVRN include Cancer-Associated Retinopathy and Paraneoplastic Syndromes. Among its related pathways are Phototransduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium sensitive guanylate cyclase activator activity. An important paralog of this gene is HPCAL1.
UniProtKB/Swiss-Prot for RCVRN Gene
-
Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.
Additional gene information for RCVRN Gene
- Monarch Initiative
- Search for RCVRN at DataMed
- Search for RCVRN at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCVRN Gene
Genomics for RCVRN Gene
GeneHancer (GH) Regulatory Elements for RCVRN Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17I009905 | Promoter | 0.5 | EPDnew | 558.2 | +0.0 | 30 | 0.1 | RCVRN PIR50616 GC17P009878 | ||
GH17I009906 | Promoter | 0.5 | EPDnew | 550.8 | +0.3 | 330 | 0.1 | PIR50616 RCVRN GC17P009878 | ||
GH17I009928 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 12 | -23.4 | -23353 | 1 | CTCF ZNF384 MNT RAD21 RFX5 MAFF JUND STAT3 SMC3 RCOR1 | RCVRN GC17M009941 GC17P009918 GAS7 | |
GH17I009841 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 10.8 | +63.2 | 63236 | 2.1 | FOXA2 ZNF48 FOSL2 RXRA FOXA3 USF2 REST MNT PPARG FOXA1 | GC17M009839 RCVRN GC17P009848 GLP2R | |
GH17I009968 | Enhancer | 0.9 | ENCODE dbSUPER | 11.3 | -63.7 | -63715 | 2 | NCOA3 ESRRA RFX1 NEUROD1 DPF2 MNT FOXA1 SREBF1 ZNF217 CTBP1 | GAS7 RCVRN GC17P009965 GC17P010023 |
Regulatory Element Products
Genomic Locations for RCVRN Gene
- chr17:9,896,320-9,905,621
- (GRCh38/hg38)
- Size:
- 9,302 bases
- Orientation:
- Minus strand
- chr17:9,799,637-9,808,938
- (GRCh37/hg19)
Genomic View for RCVRN Gene
- Cytogenetic band:
-
- 17p13.1 by Ensembl
- 17p13.1 by Entrez Gene
- 17p13.1 by HGNC


RefSeq DNA sequence for RCVRN Gene
Proteins for RCVRN Gene
-
Protein details for RCVRN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35243-RECO_HUMAN
- Recommended name:
- Recoverin
- Protein Accession:
- P35243
- Q53XL0
Protein attributes for RCVRN Gene
- Size:
- 200 amino acids
- Molecular mass:
- 23130 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Binds two calcium ions; one with high affinity, the other with low affinity.
Protein Expression for RCVRN Gene
Post-translational modifications for RCVRN Gene
Other Protein References for RCVRN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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Assay Products
No data available for DME Specific Peptides for RCVRN Gene
Domains & Families for RCVRN Gene
Gene Families for RCVRN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for RCVRN Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RCVRN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35243- Family:
-
- Belongs to the recoverin family.
Function for RCVRN Gene
Molecular function for RCVRN Gene
- UniProtKB/Swiss-Prot Function:
- Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005509 | calcium ion binding | IEA | -- |
GO:0008048 | calcium sensitive guanylate cyclase activator activity | TAS | 1672047 |
GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for RCVRN Gene
- MGI mutant phenotypes for RCVRN:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RCVRN:
Animal Models for RCVRN Gene
- MGI Knock Outs for RCVRN:
-
- Rcvrn tm1Clma
Animal Model Products
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-
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-
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-
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miRNA for RCVRN Gene
- miRTarBase miRNAs that target RCVRN
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RCVRN Gene
Localization for RCVRN Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0030425 | dendrite | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RCVRN Gene
Pathways & Interactions for RCVRN Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Phototransduction | ||
2 | Visual Cycle in Retinal Rods | ||
3 | Signaling by GPCR | ||
4 | Metabolism of fat-soluble vitamins |
Pathways by source for RCVRN Gene
4 Reactome pathways for RCVRN Gene
1 KEGG pathway for RCVRN Gene
1 Qiagen pathway for RCVRN Gene
Interacting Proteins for RCVRN Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | TAS | 1672047 |
GO:0007601 | visual perception | TAS,IEA | -- |
GO:0007602 | phototransduction | IEA | -- |
GO:0031284 | positive regulation of guanylate cyclase activity | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
No data available for SIGNOR curated interactions for RCVRN Gene
Transcripts for RCVRN Gene
mRNA/cDNA for RCVRN Gene
- (1) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (139) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
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-
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Inhibitory RNA Products
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-
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Expression for RCVRN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Eye (Sensory Organs)
- NULL (Sensory Organs)
-
Neurons
- Type2 Off Cone Bipolar Cells Inner Nuclear Layer
- Mature Rod Cells Outer Nuclear Layer
- Epithelial Cells (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for RCVRN Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RCVRN Gene
NURSA nuclear receptor signaling pathways regulating expression of RCVRN Gene:
RCVRNSOURCE GeneReport for Unigene cluster for RCVRN Gene:
Hs.80539mRNA Expression by UniProt/SwissProt for RCVRN Gene:
P35243-RECO_HUMANEvidence on tissue expression from TISSUES for RCVRN Gene
- Eye(5)
- Nervous system(4.7)
Phenotype-based relationships between genes and organs from Gene ORGANizer for RCVRN Gene
- ectoderm
- nervous
- eye
- head
Primer Products
-
OriGene qPCR primer pairs for RCVRN
-
OriGene qPCR primer pairs and template standards for RCVRN
Orthologs for RCVRN Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | RCVRN 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | RCVRN 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | RCVRN 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Rcvrn 33 |
|
||
mouse (Mus musculus) |
Mammalia | Rcvrn 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | RCVRN 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | RCVRN 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | RCVRN 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | rcvrn.1 33 |
|
||
Str.13592 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.26344 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | rcvrna 33 34 |
|
||
RCVRN (4 of 4) 34 |
|
OneToMany | |||
rcv1 34 |
|
OneToMany | |||
RCVRN (1 of 4) 34 |
|
OneToMany | |||
wufk53a03 33 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | CG7646 34 |
|
OneToOne | |
worm (Caenorhabditis elegans) |
Secernentea | ncs-2 34 |
|
OneToOne |
- Species where no ortholog for RCVRN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RCVRN Gene
Paralogs for RCVRN Gene
(15) SIMAP similar genes for RCVRN Gene using alignment to 1 proteins:
Variants for RCVRN Gene
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000581302 | -- | 9,906,782(-) | G/A | upstream_transcript_variant | |
rs1000697346 | -- | 9,906,988(-) | C/T | upstream_transcript_variant | |
rs1001353468 | -- | 9,902,147(-) | C/G/T | intron_variant | |
rs1001546157 | -- | 9,906,235(-) | A/C | upstream_transcript_variant | |
rs1002200003 | -- | 9,902,600(-) | G/T | intron_variant |
Additional Variant Information for RCVRN Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RCVRN
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCVRN Gene
Disorders for RCVRN Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
cancer-associated retinopathy |
|
|
paraneoplastic syndromes |
|
|
lung cancer |
|
|
small cell cancer of the lung |
|
|
retinitis pigmentosa |
|
Additional Disease Information for RCVRN
No data available for UniProtKB/Swiss-Prot and Genatlas for RCVRN Gene
Publications for RCVRN Gene
- Isolation of human retinal genes: recoverin cDNA and gene. (PMID: 1387789) Murakami A … Inana G (Biochemical and biophysical research communications 1992) 2 3 4 22 58
- Aberrantly expressed recoverin is functionally associated with G-protein-coupled receptor kinases in cancer cell lines. (PMID: 12507501) Miyagawa Y … Nakazawa M (Biochemical and biophysical research communications 2003) 2 3 22 58
- Expression of a photoreceptor protein, recoverin, as a cancer-associated retinopathy autoantigen in human lung cancer cell lines. (PMID: 8912538) Matsubara S … Takahara J (British journal of cancer 1996) 3 4 22 58
- Molecular cloning and nucleotide sequence of a cDNA encoding recoverin from human retina. (PMID: 8500558) Wiechmann AF … Hammarback JA (Experimental eye research 1993) 3 4 22 58
- Recoverin in pineal organs and retinae of various vertebrate species including man. (PMID: 1467959) Korf HW … Klein DC (Brain research 1992) 2 3 22 58
Products for RCVRN Gene
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Sources for RCVRN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew