RCVRN Gene

Aliases
for RCVRN gene

Previous GC identifer: GC17M009742

Summaries
for RCVRN gene

Genomic Views
for RCVRN gene

RefSeq DNA sequence:

NC_000017.10  NC_018928.1  NT_010718.16  

SwitchGear Promoter luciferase reporter plasmid: RCVRN promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCVRN

RCVRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M009799:  view genomic region     (about GC identifiers)

Proteins
for RCVRN gene

1 PDB 3D structure from and Proteopedia for RCVRN:

2D8N (3D)    

Explore the universe of human proteins at neXtProt for RCVRN: NX_P35243

Post-translational modifications:

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	OriGene Purified Protein: RCVRN OriGene Protein Over-expression Lysate: RCVRN OriGene Custom Protein Services for RCVRN
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	Novus Biologicals RCVRN Proteins Novus Biologicals RCVRN Lysates
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	ProSpec Recombinant Protein for RCVRN
	Uscn Proteins for RCVRN

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	ThermoFisher Antibodies for RCVRN

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	GenScript Custom Assay Services for RCVRN
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	Uscn ELISAs and CLIAs for RCVRN

Protein Domains /
Families
for RCVRN gene

ProtoNet protein and cluster: P35243

Function
for RCVRN gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCVRN
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate RCVRN (see all 10):
		hsa-miR-3130-5p hsa-miR-3117-3p hsa-miR-3139 hsa-miR-500a hsa-miR-4267 hsa-miR-1912 hsa-miR-27b* hsa-miR-708
		SwitchGear 3'UTR luciferase reporter plasmid: RCVRN 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RCVRN (see all 7) OriGene shRNA RFP: RCVRN OriGene siRNA: RCVRN
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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for RCVRN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RCVRN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RCVRN OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RCVRN (NM_002903)
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCVRN

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Rcvrn)

Pathways & Interactions
for RCVRN gene

	Super-pathway	contained gene-specific pathways
1	Visual signal transduction- Rods	Phototransduction 0.44

1         Kegg Pathway  (Kegg details for RCVRN)

Phototransduction

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for RCVRN gene

Transcripts
for RCVRN gene

Expression
for RCVRN gene

RCVRN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCTGTGCT

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeInner Nuclear LayerType2 Off Cone Bipolar Cells			Bipolar, Retina
	EyeOuter Nuclear LayerMature Rod Cells			Photoreceptors, Retina
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 7 LifeMap Cells
	Name			Category
	Optic cup structures (Generation of strati...)
	Retinal cells (Generation of retina...)
	Retinal progenitor-like cells (Generation of retina...)
	Photoreceptors-like cells (Generation of photor...)
	Photoreceptor-like cells (Generation of retina...)			Eye
	Photoreceptor-like cells (Generation of retina...)
	Retina-like cells (Generation of retina...)

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCVRN

Orthologs
for RCVRN gene

Paralogs
for RCVRN gene

Paralogs for RCVRN gene

HPCA²  KCNIP3²  KCNIP4²  GUCA1A²  KCNIP1²  HPCAL1²  GUCA1B²  NCALD²  

KCNIP2²  HPCAL4²  NCS1²  VSNL1²  GUCA1C²  

16 SIMAP similar genes for RCVRN using alignment to 2 protein entries:     RECO_HUMAN (see all proteins):

RCV1    DKFZp781K1922    HPCAL1    NCALD    HPCA    VSNL1

HPCAL4    KCNIP2    NCS1    KCNIP3    KCNIP4    GUCA1A

GUCA1B    DKFZp686E1183    KCNIP1    GUCA1C

RCVRN for paralogs           About GeneDecksing

Genomic Variants
for RCVRN gene

10/252 NCBI SNPs in RCVRN are shown (see all 252)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs744767841,2	C,F,	--	9800529(+)	CTTTGC/TGTGGT	1	--	ds5001		3		NA	124
rs604173661,2	C,	--	9800530(+)	TTTGCG/TTGGTC	1	--	ds5001		2		WA	120
rs1177757121,2	F,	--	9800585(+)	CTCCTC/ACTTCT	1	--	ds5001		1		NA	120
rs728222011,2	C,F,	--	9800658(+)	TGTGTT/GGGCCG	1	--	ds5001		1		NA	120
rs80761851,2	C,	--	9800698(+)	CCCGTC/G/TCCCCG	1	--	ds5001		4		NA WA	242
rs620644851,2	C,F,	--	9800717(+)	GCAGTG/CGTTCT	1	--	ds5001		3		NA	124
rs1443231191,2	C,	--	9800731(+)	TTTAA-/ATCTCCC TTCGTCAGGGATGTG	1	--	ds5001		0	--	--	--	--
rs620644861,2		--	9800735(+)	AATCTG/CCCTTC	1	--	ds5001		1		NA	2
rs620644871,2		--	9800736(+)	ATCTCC/ACTTCG	1	--	ds5001		1		NA	2
rs756414771,2		--	9800737(+)	TCTCCC/ATTCGT	1	--	ds5001		1		NA	2

HapMap Linkage Disequilibrium report for RCVRN (9799637 - 9808938 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RCVRN
     1 CNV: 4989

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RCVRN

DNA2.0 Custom Variant and Variant Library Synthesis for RCVRN

Disorders / Diseases
for RCVRN gene

20/23 diseases for RCVRN

10/28 Novoseek disease relationships for RCVRN gene (see all 28)    About this table

Publications
for RCVRN gene

PubMed articles for RCVRN gene, integrated from 9 sources (see all 213): (articles sorted by number of sources associating them with RCVRN)

Utopia: connect your pdf to the dynamic world of online information

1. Isolation of human retinal genes: recoverin cDNA and gene. (PubMed id 1387789)^{1, 2, 3, 9} Murakami A.... Inana G. (1992)
2. Recoverin in pineal organs and retinae of various vertebrate species including man. (PubMed id 1467959)^{1, 3, 9} Korf H.W....Klein D.C. (1992)
3. Expression of a photoreceptor protein, recoverin, as a cancer- associated retinopathy autoantigen in human lung cancer cell lines. (PubMed id 8912538)^{1, 2, 9} Matsubara S.... Takahara J. (1996)
4. Molecular cloning and nucleotide sequence of a cDNA encoding recoverin from human retina. (PubMed id 8500558)^{1, 2, 9} Wiechmann A.F. and Hammarback J.A. (1993)
5. Aberrantly expressed recoverin is functionally associated with G-protein-coupled receptor kinases in cancer cell lines. (PubMed id 12507501)^{1, 3, 9} Miyagawa Y....Nakazawa M. (2003)
6. Functional analysis of the human recoverin gene promoter. (PubMed id 12789533)^{1, 3, 9} Wiechmann A. and Howard E. (2003)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. The cancer-associated retinopathy antigen is a recoverin-like protein. (PubMed id 1388144)^{1, 2} Thirkill C.E.... Keltner J.L. (1992)
9. A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy. (PubMed id 1999465)^{1, 2} Polans A.S.... Palczewski K. (1991)
10. Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin. (PubMed id 18266817)^{1, 9} Torisawa A....Kawamura S. (2008)

External Searches for RCVRN gene

Genome Databases showing RCVRN gene

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Products
for RCVRN gene