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Aliases for RCVRN Gene

Aliases for RCVRN Gene

  • Recoverin 2 3
  • RCV1 3 4 6
  • Cancer-Associated Retinopathy Protein 3 4
  • Cancer Associated Retinopathy Antigen 3
  • Protein CAR 4

External Ids for RCVRN Gene

Previous HGNC Symbols for RCVRN Gene

  • RCV1

Previous GeneCards Identifiers for RCVRN Gene

  • GC17M009742
  • GC17M009799

Summaries for RCVRN Gene

Entrez Gene Summary for RCVRN Gene

  • This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]

GeneCards Summary for RCVRN Gene

RCVRN (Recoverin) is a Protein Coding gene. Diseases associated with RCVRN include autoimmune retinopathy and retinitis pigmentosa. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include calcium ion binding and calcium sensitive guanylate cyclase activator activity. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot for RCVRN Gene

  • Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCVRN Gene

Genomics for RCVRN Gene

Regulatory Elements for RCVRN Gene

Genomic Location for RCVRN Gene

Start:
9,896,320 bp from pter
End:
9,905,621 bp from pter
Size:
9,302 bases
Orientation:
Minus strand

Genomic View for RCVRN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RCVRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCVRN Gene

Proteins for RCVRN Gene

  • Protein details for RCVRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35243-RECO_HUMAN
    Recommended name:
    Recoverin
    Protein Accession:
    P35243
    Secondary Accessions:
    • Q53XL0

    Protein attributes for RCVRN Gene

    Size:
    200 amino acids
    Molecular mass:
    23130 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Binds two calcium ions; one with high affinity, the other with low affinity

    Three dimensional structures from OCA and Proteopedia for RCVRN Gene

neXtProt entry for RCVRN Gene

Proteomics data for RCVRN Gene at MOPED

Post-translational modifications for RCVRN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RCVRN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RCVRN Gene

Domains for RCVRN Gene

Gene Families for RCVRN Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for RCVRN Gene

Suggested Antigen Peptide Sequences for RCVRN Gene

Graphical View of Domain Structure for InterPro Entry

P35243

UniProtKB/Swiss-Prot:

RECO_HUMAN :
  • P35243
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the recoverin family.
genes like me logo Genes that share domains with RCVRN: view

Function for RCVRN Gene

Molecular function for RCVRN Gene

UniProtKB/Swiss-Prot Function: Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse

Gene Ontology (GO) - Molecular Function for RCVRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008048 calcium sensitive guanylate cyclase activator activity TAS 1672047
genes like me logo Genes that share ontologies with RCVRN: view

Phenotypes for RCVRN Gene

MGI mutant phenotypes for RCVRN:
inferred from 1 alleles
GenomeRNAi human phenotypes for RCVRN:
genes like me logo Genes that share phenotypes with RCVRN: view

Animal Models for RCVRN Gene

MGI Knock Outs for RCVRN:

Animal Model Products

miRNA for RCVRN Gene

miRTarBase miRNAs that target RCVRN

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RCVRN Gene

Localization for RCVRN Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RCVRN Gene COMPARTMENTS Subcellular localization image for RCVRN gene
Compartment Confidence
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RCVRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with RCVRN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RCVRN Gene

Pathways for RCVRN Gene

genes like me logo Genes that share pathways with RCVRN: view

Pathways by source for RCVRN Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RCVRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 1672047
GO:0007601 visual perception IEA --
GO:0007602 phototransduction --
GO:0007603 phototransduction, visible light TAS --
GO:0016056 rhodopsin mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with RCVRN: view

Compounds for RCVRN Gene

(1) HMDB Compounds for RCVRN Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for RCVRN Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
MYRISTIC ACID
target

(11) Novoseek inferred chemical compound relationships for RCVRN Gene

Compound -log(P) Hits PubMed IDs
guanylate 62.9 13
calcium 59.4 148
cgmp 47.8 6
myristic acid 34.3 3
retinoic acid 16.4 1
genes like me logo Genes that share compounds with RCVRN: view

Transcripts for RCVRN Gene

mRNA/cDNA for RCVRN Gene

(139) Selected AceView cDNA sequences:
(12) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RCVRN Gene

Recoverin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RCVRN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCVRN Gene

No ASD Table

Relevant External Links for RCVRN Gene

GeneLoc Exon Structure for
RCVRN
ECgene alternative splicing isoforms for
RCVRN

Expression for RCVRN Gene

mRNA expression in normal human tissues for RCVRN Gene

mRNA differential expression in normal tissues according to GTEx for RCVRN Gene

This gene is overexpressed in Whole Blood (5.8) and Brain - Frontal Cortex (BA9) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RCVRN Gene

SOURCE GeneReport for Unigene cluster for RCVRN Gene Hs.80539

mRNA Expression by UniProt/SwissProt for RCVRN Gene

P35243-RECO_HUMAN
Tissue specificity: Retina and pineal gland
genes like me logo Genes that share expressions with RCVRN: view

In Situ Assay Products

Orthologs for RCVRN Gene

This gene was present in the common ancestor of animals.

Orthologs for RCVRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RCVRN 35
  • 99.67 (n)
  • 100 (a)
RCVRN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RCVRN 35
  • 89.18 (n)
  • 89.01 (a)
RCVRN 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RCVRN 35
  • 89.01 (n)
  • 89.01 (a)
RCVRN 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rcvrn 35
  • 87.71 (n)
  • 88.89 (a)
Rcvrn 16
Rcvrn 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RCVRN 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RCVRN 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rcvrn 35
  • 88.22 (n)
  • 88.89 (a)
lizard
(Anolis carolinensis)
Reptilia RCVRN 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.26344 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rcvrn.1 35
  • 79.46 (n)
  • 80.81 (a)
Str.13592 35
zebrafish
(Danio rerio)
Actinopterygii rcv1 36
  • 65 (a)
OneToMany
RCVRN (1 of 4) 36
  • 59 (a)
OneToMany
RCVRN (4 of 4) 36
  • 67 (a)
OneToMany
rcvrna 35
  • 70.2 (n)
  • 72.22 (a)
rcvrna 36
  • 70 (a)
OneToMany
wufk53a03 35
fruit fly
(Drosophila melanogaster)
Insecta CG7646 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ncs-2 36
  • 46 (a)
OneToOne
Species with no ortholog for RCVRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCVRN Gene

ENSEMBL:
Gene Tree for RCVRN (if available)
TreeFam:
Gene Tree for RCVRN (if available)

Paralogs for RCVRN Gene

Selected SIMAP similar genes for RCVRN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RCVRN: view

Variants for RCVRN Gene

Sequence variations from dbSNP and Humsavar for RCVRN Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs887259 -- 9,898,007(+) GCGCG(C/T)GTGTG utr-variant-3-prime
rs1063540 -- 9,905,090(-) TGCTC(C/T)GGGTA frameshift-variant, reference
rs1558226 -- 9,903,763(+) tgcac(A/G)aacac intron-variant
rs1558227 -- 9,903,782(+) gagcc(A/G)actac intron-variant
rs1558228 -- 9,903,795(+) ccctg(A/G)gctcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCVRN Gene

Variant ID Type Subtype PubMed ID
nsv833360 CNV Loss 17160897
nsv833361 CNV Gain 17160897
dgv38n68 CNV Loss 17160897
nsv516119 CNV Loss 19592680

Relevant External Links for RCVRN Gene

HapMap Linkage Disequilibrium report
RCVRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCVRN Gene

Disorders for RCVRN Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for RCVRN Gene including...

Search for RCVRN Gene in MalaCards »

(1) University of Copenhagen DISEASES for RCVRN Gene

(28) Novoseek inferred disease relationships for RCVRN Gene

Disease -log(P) Hits PubMed IDs
retinopathy 81.2 51
paraneoplastic syndromes 79.8 10
retinal degeneration 74 6
retinitis pigmentosa 61.8 8
small cell lung cancer 49.6 8
genes like me logo Genes that share disorders with RCVRN: view

No data available for UniProtKB/Swiss-Prot for RCVRN Gene

Publications for RCVRN Gene

  1. Isolation of human retinal genes: recoverin cDNA and gene. (PMID: 1387789) Murakami A. … Inana G. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23
  2. Recoverin in pineal organs and retinae of various vertebrate species including man. (PMID: 1467959) Korf H.W. … Klein D.C. (Brain Res. 1992) 2 3 23
  3. Molecular cloning and nucleotide sequence of a cDNA encoding recoverin from human retina. (PMID: 8500558) Wiechmann A.F. … Hammarback J.A. (Exp. Eye Res. 1993) 3 4 23
  4. Expression of a photoreceptor protein, recoverin, as a cancer- associated retinopathy autoantigen in human lung cancer cell lines. (PMID: 8912538) Matsubara S. … Takahara J. (Br. J. Cancer 1996) 3 4 23
  5. Functional analysis of the human recoverin gene promoter. (PMID: 12789533) Wiechmann A. … Howard E. (Curr. Eye Res. 2003) 2 3 23

Products for RCVRN Gene

Sources for RCVRN Gene

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