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Aliases for RCSD1 Gene

Aliases for RCSD1 Gene

  • RCSD Domain Containing 1 2 3 5
  • RCSD Domain-Containing Protein 1 3 4
  • Protein Kinase Substrate CapZIP 3 4
  • CAPZIP 3 4
  • Protein Kinase Substrate MK2S4 3
  • CapZ Interacting Protein 2
  • CapZ-Interacting Protein 3
  • MK2S4 3

External Ids for RCSD1 Gene

Previous GeneCards Identifiers for RCSD1 Gene

  • GC01P164331
  • GC01P165865
  • GC01P138845

Summaries for RCSD1 Gene

GeneCards Summary for RCSD1 Gene

RCSD1 (RCSD Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include actin filament binding.

UniProtKB/Swiss-Prot for RCSD1 Gene

  • Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.

Additional gene information for RCSD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCSD1 Gene

Genomics for RCSD1 Gene

Regulatory Elements for RCSD1 Gene

Enhancers for RCSD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H167615 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.5 -12.5 -12515 3 HDGF ATF1 CBX5 GATA2 ATF7 RUNX3 NCOA1 ZNF592 SMARCA4 MYNN RCSD1 CREG1 POU2F1 CD247 GC01P167591
GH01H167626 1.7 FANTOM5 ENCODE dbSUPER 19.8 +0.5 472 8 HDGF PKNOX1 FOXA2 ARNT SIN3A ARID4B FEZF1 YY1 ZNF766 CBX5 MPZL1 DUTP6 RCSD1 CREG1 ENSG00000241666 POU2F1 CD247
GH01H167660 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +33.9 33879 6 KLF17 BATF ZNF143 FOS ETV6 RUNX3 CREM IKZF2 JUNB NR2F2 RCSD1 CREG1 MPZL1 ENSG00000232194 ENSG00000250762 XCL2 ENSG00000241666 TRP-CGG1-1
GH01H167658 1.5 Ensembl ENCODE dbSUPER 13.5 +29.3 29309 1 PKNOX1 ARNT FEZF1 ZNF2 GLIS2 KLF7 TSHZ1 ZNF488 SMARCB1 ZNF518A POU2F1 LOC441914 FMO11P CNN2P10 RCSD1 ADCY10 ENSG00000241666 TRP-CGG1-1
GH01H167599 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -28.6 -28593 3 HDAC1 HDGF PKNOX1 ATF1 ARNT RAD21 GATA2 ZNF143 ATF7 RUNX3 MPZL1 RCSD1 POU2F1 GC01P167591
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RCSD1 on UCSC Golden Path with GeneCards custom track

Promoters for RCSD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000015261 707 1601 HDGF PKNOX1 ARNT SIN3A ELK1 ZNF207 RUNX3 JUNB NCOA1 REST

Genomic Location for RCSD1 Gene

Chromosome:
1
Start:
167,630,093 bp from pter
End:
167,708,696 bp from pter
Size:
78,604 bases
Orientation:
Plus strand

Genomic View for RCSD1 Gene

Genes around RCSD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCSD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCSD1 Gene

Proteins for RCSD1 Gene

  • Protein details for RCSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6JBY9-CPZIP_HUMAN
    Recommended name:
    CapZ-interacting protein
    Protein Accession:
    Q6JBY9
    Secondary Accessions:
    • B1AK48
    • Q4G0E7
    • Q6IN93
    • Q8IZM2
    • Q96DX0
    • Q9NST4

    Protein attributes for RCSD1 Gene

    Size:
    416 amino acids
    Molecular mass:
    44504 Da
    Quaternary structure:
    • Interacts with CAPZA2 and CAPZB.
    SequenceCaution:
    • Sequence=CAB70910.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RCSD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RCSD1 Gene

Post-translational modifications for RCSD1 Gene

  • Dephosphorylation results in its dissociation from CAPZA2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RCSD1 Gene

No data available for DME Specific Peptides for RCSD1 Gene

Domains & Families for RCSD1 Gene

Gene Families for RCSD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RCSD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RCSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RCSD1: view

No data available for UniProtKB/Swiss-Prot for RCSD1 Gene

Function for RCSD1 Gene

Molecular function for RCSD1 Gene

UniProtKB/Swiss-Prot Function:
Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.

Phenotypes From GWAS Catalog for RCSD1 Gene

Gene Ontology (GO) - Molecular Function for RCSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IPI 15850461
genes like me logo Genes that share ontologies with RCSD1: view
genes like me logo Genes that share phenotypes with RCSD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RCSD1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RCSD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RCSD1 Gene

Localization for RCSD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RCSD1 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RCSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005884 actin filament IC 15850461
genes like me logo Genes that share ontologies with RCSD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RCSD1 Gene

Pathways & Interactions for RCSD1 Gene

SuperPathways for RCSD1 Gene

No Data Available

Interacting Proteins for RCSD1 Gene

Gene Ontology (GO) - Biological Process for RCSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003009 skeletal muscle contraction ISS --
GO:0071474 cellular hyperosmotic response IDA 15850461
genes like me logo Genes that share ontologies with RCSD1: view

No data available for Pathways by source and SIGNOR curated interactions for RCSD1 Gene

Drugs & Compounds for RCSD1 Gene

No Compound Related Data Available

Transcripts for RCSD1 Gene

Unigene Clusters for RCSD1 Gene

RCSD domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RCSD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RCSD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3:

Relevant External Links for RCSD1 Gene

GeneLoc Exon Structure for
RCSD1
ECgene alternative splicing isoforms for
RCSD1

Expression for RCSD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RCSD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RCSD1 Gene

This gene is overexpressed in Whole Blood (x9.6) and Spleen (x4.6).

Protein differential expression in normal tissues from HIPED for RCSD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7), Lymph node (10.6), Lavage (10.4), and Adrenal (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RCSD1 Gene



Protein tissue co-expression partners for RCSD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RCSD1 Gene:

RCSD1

SOURCE GeneReport for Unigene cluster for RCSD1 Gene:

Hs.493867

mRNA Expression by UniProt/SwissProt for RCSD1 Gene:

Q6JBY9-CPZIP_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and more weakly in cardiac muscle. Also expressed in several lymphoid organs, including spleen, thymus, peripheral blood leukocytes, lymph node and bone marrow.

Evidence on tissue expression from TISSUES for RCSD1 Gene

  • Blood(4.4)
  • Liver(4.2)
  • Nervous system(4.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with RCSD1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RCSD1 Gene

Orthologs for RCSD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RCSD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RCSD1 33 34
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia RCSD1 33 34
  • 82.41 (n)
dog
(Canis familiaris)
Mammalia RCSD1 33 34
  • 77.92 (n)
rat
(Rattus norvegicus)
Mammalia Rcsd1 33
  • 72.57 (n)
mouse
(Mus musculus)
Mammalia Rcsd1 33 16 34
  • 72.55 (n)
oppossum
(Monodelphis domestica)
Mammalia RCSD1 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RCSD1 34
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves RCSD1 33 34
  • 59.66 (n)
lizard
(Anolis carolinensis)
Reptilia RCSD1 34
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dub 34
  • 38 (a)
OneToMany
RCSD1 (2 of 2) 34
  • 35 (a)
OneToMany
Species where no ortholog for RCSD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RCSD1 Gene

ENSEMBL:
Gene Tree for RCSD1 (if available)
TreeFam:
Gene Tree for RCSD1 (if available)

Paralogs for RCSD1 Gene

No data available for Paralogs for RCSD1 Gene

Variants for RCSD1 Gene

Sequence variations from dbSNP and Humsavar for RCSD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000000830 -- 167,657,664(+) TGGTT(C/T)TGATA intron-variant
rs1000031873 -- 167,657,303(+) GTGTG(C/G)GGCCT intron-variant
rs1000034004 -- 167,668,951(+) AATGT(A/G)GTTAA intron-variant
rs1000049277 -- 167,693,646(+) TGAAC(A/G)TGTGG intron-variant
rs1000104543 -- 167,702,048(+) GGTTG(C/G)ATTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCSD1 Gene

Variant ID Type Subtype PubMed ID
esv3542167 CNV deletion 23714750
nsv1078878 OTHER inversion 25765185

Variation tolerance for RCSD1 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RCSD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RCSD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCSD1 Gene

Disorders for RCSD1 Gene

Relevant External Links for RCSD1

Genetic Association Database (GAD)
RCSD1
Human Genome Epidemiology (HuGE) Navigator
RCSD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RCSD1

No disorders were found for RCSD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCSD1 Gene

Publications for RCSD1 Gene

  1. The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. (PMID: 15850461) Eyers CE … Cohen P (The Biochemical journal 2005) 2 3 4 60
  2. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung CL … Kung AW (Human molecular genetics 2009) 3 45 60
  3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 45 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60

Products for RCSD1 Gene

Sources for RCSD1 Gene

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