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Aliases for RCSD1 Gene

Aliases for RCSD1 Gene

  • RCSD Domain Containing 1 2 3 5
  • RCSD Domain-Containing Protein 1 3 4
  • Protein Kinase Substrate CapZIP 3 4
  • CAPZIP 3 4
  • Protein Kinase Substrate MK2S4 3
  • CapZ Interacting Protein 2
  • CapZ-Interacting Protein 3
  • MK2S4 3

External Ids for RCSD1 Gene

Previous GeneCards Identifiers for RCSD1 Gene

  • GC01P164331
  • GC01P165865
  • GC01P138845

Summaries for RCSD1 Gene

GeneCards Summary for RCSD1 Gene

RCSD1 (RCSD Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin filament binding.

UniProtKB/Swiss-Prot for RCSD1 Gene

  • Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.

Additional gene information for RCSD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCSD1 Gene

Genomics for RCSD1 Gene

GeneHancer (GH) Regulatory Elements for RCSD1 Gene

Promoters and enhancers for RCSD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I167626 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 569.8 +0.5 472 8.1 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B FEZF1 YY1 POLR2B ZNF766 RCSD1 ENSG00000241666 MPZL1 DUTP6 CREG1 POU2F1 CD247
GH01I167615 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.5 -12.5 -12514 3.6 HDGF SMAD1 ATF1 NCOA2 ZNF280A POLR2B CBX5 ATF7 RUNX3 RXRA RCSD1 CREG1 POU2F1 CD247 GC01P167591
GH01I167658 Enhancer 1.4 Ensembl ENCODE dbSUPER 13.5 +29.3 29308 1.2 PKNOX1 ARNT FEZF1 ZNF2 GLIS2 ZNF213 KLF7 TSHZ1 ZNF488 ZNF518A POU2F1 RCSD1 ENSG00000241666 TRP-CGG1-1
GH01I167660 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +33.9 33879 6.8 KLF17 BATF IRF4 ZNF143 ETV6 FOS BCLAF1 IKZF2 RUNX3 RXRA RCSD1 CREG1 MPZL1 ENSG00000232194 ENSG00000250762 XCL2 ENSG00000241666 TRP-CGG1-1
GH01I167599 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -28.6 -28593 3.4 HDGF ATF1 PKNOX1 ARNT IRF4 ARID2 ZNF143 ATF7 RUNX3 RXRA MPZL1 RCSD1 POU2F1 GC01P167591
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RCSD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RCSD1 gene promoter:

Genomic Locations for RCSD1 Gene

Genomic Locations for RCSD1 Gene
chr1:167,630,093-167,708,696
(GRCh38/hg38)
Size:
78,604 bases
Orientation:
Plus strand
chr1:167,599,330-167,675,486
(GRCh37/hg19)

Genomic View for RCSD1 Gene

Genes around RCSD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCSD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCSD1 Gene

Proteins for RCSD1 Gene

  • Protein details for RCSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6JBY9-CPZIP_HUMAN
    Recommended name:
    CapZ-interacting protein
    Protein Accession:
    Q6JBY9
    Secondary Accessions:
    • B1AK48
    • Q4G0E7
    • Q6IN93
    • Q8IZM2
    • Q96DX0
    • Q9NST4

    Protein attributes for RCSD1 Gene

    Size:
    416 amino acids
    Molecular mass:
    44504 Da
    Quaternary structure:
    • Interacts with CAPZA2 and CAPZB.
    SequenceCaution:
    • Sequence=CAB70910.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RCSD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RCSD1 Gene

Post-translational modifications for RCSD1 Gene

Other Protein References for RCSD1 Gene

No data available for DME Specific Peptides for RCSD1 Gene

Domains & Families for RCSD1 Gene

Gene Families for RCSD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RCSD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RCSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RCSD1: view

No data available for UniProtKB/Swiss-Prot for RCSD1 Gene

Function for RCSD1 Gene

Molecular function for RCSD1 Gene

UniProtKB/Swiss-Prot Function:
Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.

Phenotypes From GWAS Catalog for RCSD1 Gene

Gene Ontology (GO) - Molecular Function for RCSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IPI 15850461
genes like me logo Genes that share ontologies with RCSD1: view
genes like me logo Genes that share phenotypes with RCSD1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RCSD1 Gene

Localization for RCSD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RCSD1 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RCSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005884 actin filament IC 15850461
genes like me logo Genes that share ontologies with RCSD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RCSD1 Gene

Pathways & Interactions for RCSD1 Gene

SuperPathways for RCSD1 Gene

No Data Available

Interacting Proteins for RCSD1 Gene

Gene Ontology (GO) - Biological Process for RCSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003009 skeletal muscle contraction ISS --
GO:0071474 cellular hyperosmotic response IDA 15850461
genes like me logo Genes that share ontologies with RCSD1: view

No data available for Pathways by source and SIGNOR curated interactions for RCSD1 Gene

Drugs & Compounds for RCSD1 Gene

No Compound Related Data Available

Transcripts for RCSD1 Gene

Unigene Clusters for RCSD1 Gene

RCSD domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCSD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3:

Relevant External Links for RCSD1 Gene

GeneLoc Exon Structure for
RCSD1
ECgene alternative splicing isoforms for
RCSD1

Expression for RCSD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RCSD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RCSD1 Gene

This gene is overexpressed in Whole Blood (x9.6) and Spleen (x4.6).

Protein differential expression in normal tissues from HIPED for RCSD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7), Lymph node (10.6), Lavage (10.4), and Adrenal (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RCSD1 Gene



Protein tissue co-expression partners for RCSD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RCSD1 Gene:

RCSD1

SOURCE GeneReport for Unigene cluster for RCSD1 Gene:

Hs.493867

mRNA Expression by UniProt/SwissProt for RCSD1 Gene:

Q6JBY9-CPZIP_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and more weakly in cardiac muscle. Also expressed in several lymphoid organs, including spleen, thymus, peripheral blood leukocytes, lymph node and bone marrow.

Evidence on tissue expression from TISSUES for RCSD1 Gene

  • Blood(4.4)
  • Liver(4.2)
  • Nervous system(4.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with RCSD1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RCSD1 Gene

Orthologs for RCSD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RCSD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RCSD1 33 34
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia RCSD1 33 34
  • 82.41 (n)
dog
(Canis familiaris)
Mammalia RCSD1 33 34
  • 77.92 (n)
rat
(Rattus norvegicus)
Mammalia Rcsd1 33
  • 72.57 (n)
mouse
(Mus musculus)
Mammalia Rcsd1 33 16 34
  • 72.55 (n)
oppossum
(Monodelphis domestica)
Mammalia RCSD1 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RCSD1 34
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves RCSD1 33 34
  • 59.66 (n)
lizard
(Anolis carolinensis)
Reptilia RCSD1 34
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dub 34
  • 38 (a)
OneToMany
RCSD1 (2 of 2) 34
  • 35 (a)
OneToMany
Species where no ortholog for RCSD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RCSD1 Gene

ENSEMBL:
Gene Tree for RCSD1 (if available)
TreeFam:
Gene Tree for RCSD1 (if available)

Paralogs for RCSD1 Gene

No data available for Paralogs for RCSD1 Gene

Variants for RCSD1 Gene

Sequence variations from dbSNP and Humsavar for RCSD1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000000830 -- 167,657,664(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000031873 -- 167,657,303(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000034004 -- 167,668,951(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000049277 -- 167,693,646(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000104543 -- 167,702,048(+) C/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RCSD1 Gene

Variant ID Type Subtype PubMed ID
esv3542167 CNV deletion 23714750
nsv1078878 OTHER inversion 25765185

Variation tolerance for RCSD1 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RCSD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RCSD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCSD1 Gene

Disorders for RCSD1 Gene

Additional Disease Information for RCSD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RCSD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCSD1 Gene

Publications for RCSD1 Gene

  1. The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. (PMID: 15850461) Eyers CE … Cohen P (The Biochemical journal 2005) 2 3 4 58
  2. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung CL … Kung AW (Human molecular genetics 2009) 3 44 58
  3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 44 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58

Products for RCSD1 Gene

Sources for RCSD1 Gene

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