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Aliases for RCSD1 Gene

Aliases for RCSD1 Gene

  • RCSD Domain Containing 1 2 3 5
  • RCSD Domain-Containing Protein 1 3 4
  • Protein Kinase Substrate CapZIP 3 4
  • CapZ Interacting Protein 2 3
  • CAPZIP 3 4
  • Protein Kinase Substrate MK2S4 3
  • MK2S4 3

External Ids for RCSD1 Gene

Previous GeneCards Identifiers for RCSD1 Gene

  • GC01P164331
  • GC01P165865
  • GC01P138845

Summaries for RCSD1 Gene

GeneCards Summary for RCSD1 Gene

RCSD1 (RCSD Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include actin filament binding.

UniProtKB/Swiss-Prot for RCSD1 Gene

  • Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCSD1 Gene

Genomics for RCSD1 Gene

Regulatory Elements for RCSD1 Gene

Enhancers for RCSD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RCSD1 on UCSC Golden Path with GeneCards custom track

Promoters for RCSD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RCSD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RCSD1 Gene

167,630,093 bp from pter
167,708,696 bp from pter
78,604 bases
Plus strand

Genomic View for RCSD1 Gene

Genes around RCSD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCSD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCSD1 Gene

Proteins for RCSD1 Gene

  • Protein details for RCSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CapZ-interacting protein
    Protein Accession:
    Secondary Accessions:
    • B1AK48
    • Q4G0E7
    • Q6IN93
    • Q8IZM2
    • Q96DX0
    • Q9NST4

    Protein attributes for RCSD1 Gene

    416 amino acids
    Molecular mass:
    44504 Da
    Quaternary structure:
    • Interacts with CAPZA2 and CAPZB.
    • Sequence=CAB70910.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RCSD1 Gene


neXtProt entry for RCSD1 Gene

Proteomics data for RCSD1 Gene at MOPED

Post-translational modifications for RCSD1 Gene

  • Dephosphorylation results in its dissociation from CAPZA2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RCSD1 Gene

No data available for DME Specific Peptides for RCSD1 Gene

Domains & Families for RCSD1 Gene

Protein Domains for RCSD1 Gene


Suggested Antigen Peptide Sequences for RCSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RCSD domain.
  • Contains 1 RCSD domain.
genes like me logo Genes that share domains with RCSD1: view

No data available for Gene Families for RCSD1 Gene

Function for RCSD1 Gene

Molecular function for RCSD1 Gene

UniProtKB/Swiss-Prot Function:
Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.

Gene Ontology (GO) - Molecular Function for RCSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IPI 15850461
genes like me logo Genes that share ontologies with RCSD1: view
genes like me logo Genes that share phenotypes with RCSD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RCSD1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RCSD1 Gene

Localization for RCSD1 Gene

Subcellular locations from

Jensen Localization Image for RCSD1 Gene COMPARTMENTS Subcellular localization image for RCSD1 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 2
plasma membrane 2
chloroplast 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RCSD1 Gene

Pathways & Interactions for RCSD1 Gene

SuperPathways for RCSD1 Gene

No Data Available

Interacting Proteins for RCSD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000356828 for RCSD1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for RCSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003009 skeletal muscle contraction ISS --
genes like me logo Genes that share ontologies with RCSD1: view

No data available for Pathways by source and SIGNOR curated interactions for RCSD1 Gene

Drugs & Compounds for RCSD1 Gene

No Compound Related Data Available

Transcripts for RCSD1 Gene

Unigene Clusters for RCSD1 Gene

RCSD domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RCSD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -

Relevant External Links for RCSD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RCSD1 Gene

mRNA expression in normal human tissues for RCSD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RCSD1 Gene

This gene is overexpressed in Whole Blood (x9.6) and Spleen (x4.6).

Protein differential expression in normal tissues from HIPED for RCSD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7), Lymph node (10.6), Lavage (10.4), and Adrenal (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RCSD1 Gene

SOURCE GeneReport for Unigene cluster for RCSD1 Gene Hs.493867

mRNA Expression by UniProt/SwissProt for RCSD1 Gene

Tissue specificity: Highly expressed in skeletal muscle and more weakly in cardiac muscle. Also expressed in several lymphoid organs, including spleen, thymus, peripheral blood leukocytes, lymph node and bone marrow.
genes like me logo Genes that share expression patterns with RCSD1: view

Protein tissue co-expression partners for RCSD1 Gene

Primer Products

Orthologs for RCSD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RCSD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RCSD1 35
  • 82.41 (n)
  • 78.63 (a)
RCSD1 36
  • 77 (a)
(Canis familiaris)
Mammalia RCSD1 35
  • 77.92 (n)
  • 72.03 (a)
RCSD1 36
  • 68 (a)
(Mus musculus)
Mammalia Rcsd1 35
  • 72.55 (n)
  • 65.44 (a)
Rcsd1 16
Rcsd1 36
  • 65 (a)
(Pan troglodytes)
Mammalia RCSD1 35
  • 99.44 (n)
  • 99.28 (a)
RCSD1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rcsd1 35
  • 72.57 (n)
  • 64.29 (a)
(Monodelphis domestica)
Mammalia RCSD1 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia RCSD1 36
  • 38 (a)
(Gallus gallus)
Aves RCSD1 35
  • 59.66 (n)
  • 54.44 (a)
RCSD1 36
  • 48 (a)
(Anolis carolinensis)
Reptilia RCSD1 36
  • 53 (a)
(Danio rerio)
Actinopterygii dub 36
  • 38 (a)
RCSD1 (2 of 2) 36
  • 35 (a)
Species with no ortholog for RCSD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RCSD1 Gene

Gene Tree for RCSD1 (if available)
Gene Tree for RCSD1 (if available)

Paralogs for RCSD1 Gene

No data available for Paralogs for RCSD1 Gene

Variants for RCSD1 Gene

Sequence variations from dbSNP and Humsavar for RCSD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34699420 - 167,697,775(+) CCCCC(A/G)GACCG intron-variant, reference, missense
rs742469 -- 167,649,634(-) AGCCT(C/T)CTAAA intron-variant
rs742470 -- 167,648,979(+) CCCTC(A/C)GGGAG intron-variant
rs742471 -- 167,645,515(+) ATTTC(A/G)CAGAG intron-variant
rs742472 -- 167,645,508(+) CTGGG(A/G)AATTT intron-variant

Variation tolerance for RCSD1 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RCSD1 Gene

Disorders for RCSD1 Gene

Relevant External Links for RCSD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RCSD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCSD1 Gene

Publications for RCSD1 Gene

  1. The phosphorylation of CapZ-interacting protein (CapZIP) by stress- activated protein kinases triggers its dissociation from CapZ. (PMID: 15850461) Eyers C.E. … Cohen P. (Biochem. J. 2005) 2 3 4 67
  2. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3
  3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3
  4. A new partner gene fused to ABL1 in a t(1;9)(q24;q34)-associated B-cell acute lymphoblastic leukemia. (PMID: 17541395) De Braekeleer E. … De Braekeleer M. (Leukemia 2007) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for RCSD1 Gene

Sources for RCSD1 Gene