RCSD1 Gene
protein-coding GIFtS : 45
GCID: GC01 P167599
RCSD domain containing 1
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Aliasesfor RCSD1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases RCSD Domain Containing 1 1 2 RCSD Domain-Containing Protein 12 3 MK2S41 2 MGC218541 Protein Kinase Substrate CapZIP2 3 CapZ-Interacting Protein2 CAPZIP2 3 Protein Kinase Substrate MK2S42
Export aliases for RCSD1 gene to outside databases Previous GC identifers: GC01P164331 GC01P165865 GC01P138845
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Summariesfor RCSD1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: CPZIP_HUMAN, Q6JBY9 Function : Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actinfilament assembly
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Genomic Viewsfor RCSD1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004487.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RCSD1 gene promoter: GR AP-1 ATF-2 HSF1 (long) CREB deltaCREB HSF1short c-Jun GR-alpha Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for RCSD1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCSD1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q24.2 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q24.2 RCSD1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P167599: view genomic region
(about GC identifiers )
Start:
167,599,330 bp from pter
End:
167,675,486 bp from pter
Size:
76,157 bases
Orientation:
plus strand
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Proteinsfor RCSD1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CPZIP_HUMAN, Q6JBY9 (See
protein sequence )Recommended Name: CapZ-interacting protein Size : 416 amino acids; 44504 Da
Subunit : Interacts with CAPZA2 and CAPZB
Sequence caution : Sequence=CAB70910.1; Type=Erroneous initiation;
Secondary accessions : B1AK48 Q4G0E7 Q6IN93 Q8IZM2 Q96DX0 Q9NST4Alternative splicing : 2 isoforms : Q6JBY9-1 Q6JBY9-2 Explore the universe of human proteins at neXtProt for RCSD1: NX_Q6JBY9 Post-translational modifications:
Dephosphorylation results in its dissociation from CAPZA21
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6JBY9 RCSD1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_443094.3 ENSEMBL proteins: ENSP00000356828 ENSP00000355291 ENSP00000439409 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
RCSD1 for ontologies About GeneDecksing RCSD1 Antibody Products: Assay Products for RCSD1:
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Protein
Domains / Familiesfor RCSD1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RCSD1 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q6JBY9 ProtoNet protein and cluster: Q6JBY9
UniProtKB/Swiss-Prot: CPZIP_HUMAN, Q6JBY9 Similarity : Contains 1 RCSD domain
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Functionfor RCSD1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CPZIP_HUMAN, Q6JBY9 Function : Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actinfilament assembly
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RCSD1 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RCSD1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RCSD1 (NM_052862 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RCSD1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RCSD1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCSD1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
RCSD1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for RCSD1 :
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Pathways & Interactionsfor RCSD1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RCSD1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/44 Interacting proteins for RCSD1 (ENSP00000356828 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 44 )About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
RCSD1 for ontologies About GeneDecksing
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Drugs & Compoundsfor RCSD1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RCSD1 Search CenterWatch for drugs/clinical trials and news about RCSD1 / CPZIP
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Transcriptsfor RCSD1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RCSD1 gene: NM_052862.3 Unigene Cluster for RCSD1:
RCSD domain containing 1 Hs.493867 [show with all ESTs ] Unigene Representative Sequence: AF545852 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000367854 (uc001gem.3 uc010pli.2 ) ENST00000361496 ENST00000475127 ENST00000472038 ENST00000461790 ENST00000537350 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RCSD1 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RCSD1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RCSD1 (NM_052862 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RCSD1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RCSD1
Additional cDNA sequence: AF545852.1 AK025425.1 AK124221.1 AK130798.1 AL137762.1 AL833211.1 AY530954.1 BC013186.1 BC072399.1 BC098426.1 BC101536.1 BC101562.1 BC143428.1
7 DOTS entries : DT.109341 DT.101968387
DT.40243476 DT.92425297 DT.92425298 DT.92425299 DT.95280941 24/183 AceView cDNA sequences (see all 183 ):
AK124221 BC072399 AI660357 BI491018 BC013186 H22137 CF138903 BQ051659 CR618927 AW408550 BM684348 BM479517 BF507709 CR618640 BX281922 AA490598 AA490793 BQ431021 AA651889 AI573014 T77359 AA425076 AI696275 CA748758 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for RCSD1 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 SP1 :     -               SP2 :     -     -           SP3 :                  
ECgene alternative splicing isoforms for RCSD1
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Expression for RCSD1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RCSD1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image RCSD1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See RCSD1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RCSD1 SOURCE GeneReport for Unigene cluster: Hs.493867 UniProtKB/Swiss-Prot: CPZIP_HUMAN, Q6JBY9 Tissue specificity : Highly expressed in skeletal muscle and more weakly in cardiac muscle. Also expressed in severallymphoid organs, including spleen, thymus, peripheral blood leukocytes, lymph node and bone marrow SABiosciences Custom PCR Arrays for RCSD1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RCSD1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RCSD1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RCSD1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RCSD1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCSD1
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Orthologsfor RCSD1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for RCSD1 gene from 4/10 species (see all 10 ) About this table
ENSEMBL Gene Tree for RCSD1 (if available)TreeFam Gene Tree for RCSD1 (if available)
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Paralogsfor RCSD1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor RCSD1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RCSD1 (167599330 - 167675486 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RCSD1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RCSD1
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Disorders
/ Diseasesfor RCSD1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RCSD1 for disorders About GeneDecksing
OMIM gene information: 610579
OMIM disorders : --6 diseases for RCSD1 : About MalaCards acute lymphoblastic leukemia lymphoblastic leukemia essential hypertension hypertension t-cell leukemia leukemia Human Genome Epidemiology (HuGE) Navigator: RCSD1 (2 documents) Export disorders for RCSD1 gene to outside databases
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Publicationsfor RCSD1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RCSD1 gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with RCSD1) Utopia : connect your pdf to the dynamic world of online information
The phosphorylation of CapZ-interacting protein (CapZIP) by stress- activated protein kinases triggers its dissociation from CapZ. (PubMed id 15850461) 1 , 2 Eyers C.E.... Cohen P. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Large-scale proteomics analysis of the human kinome. (PubMed id 19369195) 2 Oppermann F.S.... Daub H. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332) 2 Mayya V.... Han D.K. (2009) Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175) 1 Ehret G.B....Chakravarti A. (2009) Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610) 1 Cheung C.L....Kung A.W. (2009) Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. (PubMed id 19367720) 2 Carrascal M.... Abian J. (2008) A new partner gene fused to ABL1 in a t(1;9)(q24;q34)-associated B-cell acute lymphoblastic leukemia. (PubMed id 17541395) 1 De Braekeleer E....De Braekeleer M. (2007) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 2 Gregory S.G.... Bentley D.R. (2006)
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External Searches for RCSD1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RCSD1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RCSD1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing RCSD1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for RCSD1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RCSD1 gene: Search GeneIP for patents involving RCSD1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RCSD1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for RCSD1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RCSD1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RCSD1 OriGene Protein Over-expression Lysate for RCSD1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RCSD1 OriGene 3'-UTR Clone for RCSD1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RCSD1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RCSD1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for RCSD1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RCSD1 OriGene Custom Protein Services for RCSD1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RCSD1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RCSD1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCSD1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RCSD1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RCSD1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RCSD1
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCSD1
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RCSD1
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