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Aliases for RCOR3 Gene

Aliases for RCOR3 Gene

  • REST Corepressor 3 2 3 5
  • KIAA1343 4

External Ids for RCOR3 Gene

Previous GeneCards Identifiers for RCOR3 Gene

  • GC01P208513
  • GC01P207821
  • GC01P209499
  • GC01P211433
  • GC01P182109

Summaries for RCOR3 Gene

GeneCards Summary for RCOR3 Gene

RCOR3 (REST Corepressor 3) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is RCOR2.

UniProtKB/Swiss-Prot for RCOR3 Gene

  • May act as a component of a corepressor complex that represses transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCOR3 Gene

Genomics for RCOR3 Gene

Regulatory Elements for RCOR3 Gene

Enhancers for RCOR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F210371 1.4 Ensembl ENCODE 26.3 -884.7 -884715 3.4 PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 RCOR3 SERTAD4-AS1 SERTAD4 ST13P19 HHAT GC01M210375 RNU5A-8P PIR50724
GH01F212252 1.6 FANTOM5 Ensembl ENCODE 13.2 +997.0 997024 5.2 HDGF MLX ZFP64 ARID4B DMAP1 YY1 ZNF766 KLF13 SP5 MXD4 LOC101929541 TMEM206 PPP2R5A FLVCR1 RCOR3 NEK2 LPGAT1 ATF3 GC01P212241
GH01F210290 1.5 FANTOM5 Ensembl ENCODE 13.4 -964.8 -964800 5.2 PKNOX1 FEZF1 GLIS2 FOS ZNF263 SP3 YY2 JUNB TSHZ1 TBX21 RCOR3 SERTAD4-AS1 TRAF3IP3 SYT14 HHAT GC01P210292 RNASEH1P3
GH01F212033 1.2 ENCODE 16.5 +777.9 777852 4.6 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RCOR3 RPL21P28 LOC91548 NEK2 INTS7 LPGAT1
GH01F212241 1.4 Ensembl ENCODE 13.2 +984.0 984034 2.0 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 LOC101929541 RCOR3 RPL21P28 ENSG00000212187 NEK2 ENSG00000229832 TMEM206 GC01P212241
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RCOR3 on UCSC Golden Path with GeneCards custom track

Promoters for RCOR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000288962 1423 4000 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC

Genomic Location for RCOR3 Gene

211,258,377 bp from pter
211,316,385 bp from pter
58,009 bases
Plus strand

Genomic View for RCOR3 Gene

Genes around RCOR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCOR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCOR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCOR3 Gene

Proteins for RCOR3 Gene

  • Protein details for RCOR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    REST corepressor 3
    Protein Accession:
    Secondary Accessions:
    • B3KYA2
    • B4DYY7
    • Q5VT47
    • Q7L9I5
    • Q8N5U3
    • Q9NV83

    Protein attributes for RCOR3 Gene

    495 amino acids
    Molecular mass:
    55581 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92581.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RCOR3 Gene

    Alternative splice isoforms for RCOR3 Gene


neXtProt entry for RCOR3 Gene

Post-translational modifications for RCOR3 Gene

  • Ubiquitination at Lys 20 and Lys 325
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RCOR3 Gene

Domains & Families for RCOR3 Gene

Gene Families for RCOR3 Gene

Protein Domains for RCOR3 Gene

Suggested Antigen Peptide Sequences for RCOR3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ELM2 domain.
  • Belongs to the CoREST family.
  • Contains 1 ELM2 domain.
  • Contains 2 SANT domains.
  • Belongs to the CoREST family.
genes like me logo Genes that share domains with RCOR3: view

Function for RCOR3 Gene

Molecular function for RCOR3 Gene

UniProtKB/Swiss-Prot Function:
May act as a component of a corepressor complex that represses transcription.

Gene Ontology (GO) - Molecular Function for RCOR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0003714 transcription corepressor activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0008134 transcription factor binding IBA --
genes like me logo Genes that share ontologies with RCOR3: view
genes like me logo Genes that share phenotypes with RCOR3: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RCOR3 Gene

Localization for RCOR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCOR3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RCOR3 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RCOR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005667 transcription factor complex IBA --
GO:0017053 transcriptional repressor complex IBA --
genes like me logo Genes that share ontologies with RCOR3: view

Pathways & Interactions for RCOR3 Gene

SuperPathways for RCOR3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RCOR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with RCOR3: view

No data available for Pathways by source and SIGNOR curated interactions for RCOR3 Gene

Transcripts for RCOR3 Gene

Unigene Clusters for RCOR3 Gene

REST corepressor 3:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCOR3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - -
SP5: - - - - -
SP7: - - - - - - -
SP8: - -
SP9: - -
SP10: - -
SP11: -

ExUns: 15c · 15d ^ 16a · 16b · 16c
SP2: - -
SP3: - -
SP7: - -
SP10: - -
SP12: - -

Relevant External Links for RCOR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RCOR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RCOR3 Gene

Protein differential expression in normal tissues from HIPED for RCOR3 Gene

This gene is overexpressed in Urine (23.3), Breast (16.5), and Bone (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RCOR3 Gene

Protein tissue co-expression partners for RCOR3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RCOR3 Gene:


SOURCE GeneReport for Unigene cluster for RCOR3 Gene:

genes like me logo Genes that share expression patterns with RCOR3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RCOR3 Gene

Orthologs for RCOR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCOR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RCOR3 34 35
  • 99.87 (n)
(Canis familiaris)
Mammalia RCOR3 34 35
  • 97.34 (n)
(Bos Taurus)
Mammalia RCOR3 34 35
  • 96.36 (n)
(Rattus norvegicus)
Mammalia Rcor3 34
  • 91.76 (n)
(Ornithorhynchus anatinus)
Mammalia RCOR3 35
  • 90 (a)
(Monodelphis domestica)
Mammalia RCOR3 35
  • 89 (a)
(Mus musculus)
Mammalia Rcor3 35
  • 88 (a)
(Gallus gallus)
Aves RCOR3 35
  • 93 (a)
(Anolis carolinensis)
Reptilia RCOR3 35
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rcor3 34
  • 78.4 (n)
(Danio rerio)
Actinopterygii rcor3 34 35
  • 70.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CoRest 35
  • 21 (a)
(Caenorhabditis elegans)
Secernentea rcor-1 35
  • 15 (a)
spr-1 35
  • 13 (a)
Species where no ortholog for RCOR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCOR3 Gene

Gene Tree for RCOR3 (if available)
Gene Tree for RCOR3 (if available)

Paralogs for RCOR3 Gene

Paralogs for RCOR3 Gene

(4) SIMAP similar genes for RCOR3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RCOR3: view

Variants for RCOR3 Gene

Sequence variations from dbSNP and Humsavar for RCOR3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10524651 -- 211,293,120(+) AATAA(-/ATAA/ATAAATAA)GTCTT intron-variant
rs10558137 -- 211,265,263(+) CCAAT(-/TAAATA)TAAAT intron-variant
rs10618290 -- 211,270,820(+) TCCTT(-/TGC)TGCAG intron-variant
rs10667501 -- 211,263,445(+) AGACT(-/GT/TG)AATTG intron-variant
rs10675827 -- 211,307,500(+) TAAAA(-/AG/AGGAATTTAAAA/AGGAATTTAAAG)GAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCOR3 Gene

Variant ID Type Subtype PubMed ID
nsv952066 CNV deletion 24416366
nsv159013 CNV deletion 16902084
nsv1068848 CNV deletion 25765185
esv6409 CNV gain 19470904
esv3546011 CNV deletion 23714750

Variation tolerance for RCOR3 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RCOR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCOR3 Gene

Disorders for RCOR3 Gene

Relevant External Links for RCOR3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RCOR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCOR3 Gene

Publications for RCOR3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RCOR3 Gene

Sources for RCOR3 Gene

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