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Aliases for RCOR3 Gene

Aliases for RCOR3 Gene

  • REST Corepressor 3 2 3 5
  • KIAA1343 4

External Ids for RCOR3 Gene

Previous GeneCards Identifiers for RCOR3 Gene

  • GC01P208513
  • GC01P207821
  • GC01P209499
  • GC01P211433
  • GC01P182109

Summaries for RCOR3 Gene

GeneCards Summary for RCOR3 Gene

RCOR3 (REST Corepressor 3) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is NCOR1.

UniProtKB/Swiss-Prot for RCOR3 Gene

  • May act as a component of a corepressor complex that represses transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCOR3 Gene

Genomics for RCOR3 Gene

Regulatory Elements for RCOR3 Gene

Promoters for RCOR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RCOR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RCOR3 Gene

Chromosome:
1
Start:
211,258,377 bp from pter
End:
211,316,385 bp from pter
Size:
58,009 bases
Orientation:
Plus strand

Genomic View for RCOR3 Gene

Genes around RCOR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCOR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCOR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCOR3 Gene

Proteins for RCOR3 Gene

  • Protein details for RCOR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2K3-RCOR3_HUMAN
    Recommended name:
    REST corepressor 3
    Protein Accession:
    Q9P2K3
    Secondary Accessions:
    • B3KYA2
    • B4DYY7
    • Q5VT47
    • Q7L9I5
    • Q8N5U3
    • Q9NV83

    Protein attributes for RCOR3 Gene

    Size:
    495 amino acids
    Molecular mass:
    55581 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92581.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RCOR3 Gene

    Alternative splice isoforms for RCOR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RCOR3 Gene

Proteomics data for RCOR3 Gene at MOPED

Post-translational modifications for RCOR3 Gene

  • Ubiquitination at Lys 20 and Lys 325
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RCOR3 Gene

Domains & Families for RCOR3 Gene

Gene Families for RCOR3 Gene

Protein Domains for RCOR3 Gene

Suggested Antigen Peptide Sequences for RCOR3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2K3

UniProtKB/Swiss-Prot:

RCOR3_HUMAN :
  • Contains 1 ELM2 domain.
  • Belongs to the CoREST family.
Domain:
  • Contains 1 ELM2 domain.
  • Contains 2 SANT domains.
Family:
  • Belongs to the CoREST family.
genes like me logo Genes that share domains with RCOR3: view

Function for RCOR3 Gene

Molecular function for RCOR3 Gene

UniProtKB/Swiss-Prot Function:
May act as a component of a corepressor complex that represses transcription.

Gene Ontology (GO) - Molecular Function for RCOR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with RCOR3: view
genes like me logo Genes that share phenotypes with RCOR3: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RCOR3 Gene

Localization for RCOR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCOR3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RCOR3 Gene COMPARTMENTS Subcellular localization image for RCOR3 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for RCOR3 Gene

Pathways & Interactions for RCOR3 Gene

SuperPathways for RCOR3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RCOR3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RCOR3 Gene

Drugs & Compounds for RCOR3 Gene

No Compound Related Data Available

Transcripts for RCOR3 Gene

Unigene Clusters for RCOR3 Gene

REST corepressor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RCOR3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - -
SP5: - - - - -
SP6:
SP7: - - - - - - -
SP8: - -
SP9: - -
SP10: - -
SP11: -
SP12:

ExUns: 15c · 15d ^ 16a · 16b · 16c
SP1:
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10: - -
SP11:
SP12: - -

Relevant External Links for RCOR3 Gene

GeneLoc Exon Structure for
RCOR3
ECgene alternative splicing isoforms for
RCOR3

Expression for RCOR3 Gene

mRNA expression in normal human tissues for RCOR3 Gene

Protein differential expression in normal tissues from HIPED for RCOR3 Gene

This gene is overexpressed in Urine (23.3), Breast (16.5), and Bone (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RCOR3 Gene



SOURCE GeneReport for Unigene cluster for RCOR3 Gene Hs.356399

genes like me logo Genes that share expression patterns with RCOR3: view

Protein tissue co-expression partners for RCOR3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RCOR3 Gene

Orthologs for RCOR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCOR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RCOR3 36
  • 100 (a)
OneToOne
RCOR3 35
  • 99.87 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RCOR3 35
  • 96.36 (n)
  • 98.59 (a)
RCOR3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RCOR3 36
  • 100 (a)
OneToOne
RCOR3 35
  • 97.34 (n)
  • 99.46 (a)
mouse
(Mus musculus)
Mammalia Rcor3 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RCOR3 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RCOR3 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rcor3 35
  • 91.76 (n)
  • 96.55 (a)
chicken
(Gallus gallus)
Aves RCOR3 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RCOR3 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rcor3 35
  • 78.4 (n)
  • 83.71 (a)
zebrafish
(Danio rerio)
Actinopterygii rcor3 36
  • 70 (a)
OneToOne
rcor3 35
  • 70.72 (n)
  • 77.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CoRest 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rcor-1 36
  • 15 (a)
ManyToMany
spr-1 36
  • 13 (a)
ManyToMany
Species with no ortholog for RCOR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCOR3 Gene

ENSEMBL:
Gene Tree for RCOR3 (if available)
TreeFam:
Gene Tree for RCOR3 (if available)

Paralogs for RCOR3 Gene

Paralogs for RCOR3 Gene

(4) SIMAP similar genes for RCOR3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RCOR3: view

Variants for RCOR3 Gene

Sequence variations from dbSNP and Humsavar for RCOR3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17856928 - 211,271,307(+) TGCCA(A/G)ATGGT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1983259 -- 211,309,978(-) AGAAC(A/G)GCATG intron-variant
rs1983260 -- 211,309,915(-) TAGCA(A/T)CTAAG intron-variant
rs2358216 -- 211,294,624(+) tcgct(C/G)tgtcg intron-variant
rs2358217 -- 211,294,676(+) gctcc(A/G)cctcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCOR3 Gene

Variant ID Type Subtype PubMed ID
nsv159013 CNV Loss 16902084
esv6409 CNV Gain 19470904

Variation tolerance for RCOR3 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RCOR3 Gene

HapMap Linkage Disequilibrium report
RCOR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCOR3 Gene

Disorders for RCOR3 Gene

Relevant External Links for RCOR3

Genetic Association Database (GAD)
RCOR3
Human Genome Epidemiology (HuGE) Navigator
RCOR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RCOR3

No disorders were found for RCOR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCOR3 Gene

Publications for RCOR3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3

Products for RCOR3 Gene

Sources for RCOR3 Gene

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