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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCOR3 Gene

protein-coding   GIFtS: 49
GCID: GC01P211433

REST corepressor 3

 Explore 2 diseases affiliated with
RCOR3 via our new
 Human Malady Compendium 
Biological research products
for RCOR3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
REST Corepressor 31 2
FLJ108761
RP11-318L16.12
KIAA13433

External Ids:    HGNC: 255941   Entrez Gene: 557582   Ensembl: ENSG000001176257   UniProtKB: Q9P2K33   

Export aliases for RCOR3 gene to outside databases

Previous GC identifers: GC01P208513 GC01P207821 GC01P209499 GC01P182109


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RCOR3_HUMAN, Q9P2K3
Function: May act as a component of a corepressor complex that represses transcription (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for RCOR3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRCOR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RCOR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCOR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.2   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32.3

RCOR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCOR3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P211433:  view genomic region     (about GC identifiers)

Start:
211,431,719 bp from pter      End:
211,489,727 bp from pter
Size:
58,009 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RCOR3_HUMAN, Q9P2K3 (See protein sequence)
Recommended Name: REST corepressor 3  
Size: 495 amino acids; 55581 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA92581.1; Type=Erroneous initiation;
Secondary accessions: B3KYA2 B4DYY7 Q5VT47 Q7L9I5 Q8N5U3 Q9NV83
Alternative splicing: 4 isoforms:  Q9P2K3-1   Q9P2K3-2   Q9P2K3-3   Q9P2K3-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RCOR3: NX_Q9P2K3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2K3

  • RCOR3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001129695.1  NP_001129696.2  NP_001129697.1  NP_060724.1  

    ENSEMBL proteins: 
     ENSP00000436057   ENSP00000436838   ENSP00000355973   ENSP00000398558   ENSP00000432779  
     ENSP00000413929   ENSP00000434605   ENSP00000355972   ENSP00000433441   ENSP00000437048  
     ENSP00000434181  

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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RCOR3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    RCOR3 for ontologies           About GeneDecksing



    RCOR3 Antibody Products: 
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    Uscn ELISAs and CLIAs for RCOR3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RCOR3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR000949 ELM2_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9P2K3

    ProtoNet protein and cluster: Q9P2K3

    UniProtKB/Swiss-Prot: RCOR3_HUMAN, Q9P2K3
    Similarity: Belongs to the CoREST family
    Similarity: Contains 1 ELM2 domain
    Similarity: Contains 2 SANT domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RCOR3_HUMAN, Q9P2K3
    Function: May act as a component of a corepressor complex that represses transcription (Potential)

    miRNA
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    hsa-miR-21* hsa-miR-136 hsa-miR-15a hsa-miR-128 hsa-miR-200a hsa-miR-30d hsa-miR-500a hsa-miR-141
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCOR3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI19060904


    RCOR3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for RCOR3:
     G0/1 arrest  Increased G1 DNA content 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RCOR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/21 Interacting proteins for RCOR3 (Q9P2K31, 2, 3 ENSP000004139294) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190121, 2, 3, ENSP000002540434EBI-743428,EBI-739566 MINT-66856 I2D: score=6 STRING: ENSP00000254043
    CEP70Q8NHQ12, 3, ENSP000002649824MINT-66342 I2D: score=5 STRING: ENSP00000264982
    NINLQ9Y2I62, 3, ENSP000002788864MINT-68109 I2D: score=5 STRING: ENSP00000278886
    GSE1Q146871, 3, ENSP000002534584EBI-743428,EBI-372619 I2D: score=4 STRING: ENSP00000253458
    NECAB2Q7Z6G32, 3, ENSP000003074494MINT-67388 I2D: score=4 STRING: ENSP00000307449
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    RCOR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCOR3
    Search CenterWatch for drugs/clinical trials and news about RCOR3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RCOR3 gene (4 alternative transcripts): 
    NM_001136223.1  NM_001136224.2  NM_001136225.1  NM_018254.3  

    Unigene Cluster for RCOR3:

    REST corepressor 3
    Hs.356399  [show with all ESTs]
    Unigene Representative Sequence: NM_001136223
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534478 ENST00000533469 ENST00000367006 ENST00000452621(uc001hie.3)
    ENST00000528926(uc010psv.1) ENST00000419091 ENST00000528408 ENST00000472734
    ENST00000529572 ENST00000367005(uc010psw.2 uc001hif.3 uc001hig.3 uc009xcz.3)
    ENST00000534460 ENST00000529763 ENST00000485186 ENST00000486666 ENST00000528066
    ENST00000526255

    miRNA
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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate RCOR3 (see all 45):
    hsa-miR-21* hsa-miR-136 hsa-miR-15a hsa-miR-128 hsa-miR-200a hsa-miR-30d hsa-miR-500a hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidRCOR3 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB037764.1 AK001738.1 AK057001.1 AK125810.1 AK131312.1 AK302664.1 AK311644.1 BC031608.1 

    13 DOTS entries:

    DT.446461  DT.100791231  DT.100742228  DT.99929041  DT.100791227  DT.40126075  DT.100791226  DT.437592 
    DT.100698394  DT.121458754  DT.121458771  DT.121458794  DT.65284646 

    24/185 AceView cDNA sequences (see all 185):

    AI653139 AW237171 BM126872 AI380424 BQ010823 AW021273 BX956434 AA398057 
    BQ448539 H88945 AI811045 AK001738 AU133327 BF197963 AI381540 BF115562 
    BU741914 AW341924 AA831517 BU736066 BM718325 AA044128 AK131312 BM722908 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RCOR3 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ·
    SP1:              -           -           -     -     -                                                           -           -     -           -     -         
    SP2:                          -           -     -     -                                                           -           -     -           -     -         
    SP3:              -           -           -     -     -                                                           -           -     -           -     -     -   
    SP4:              -                       -     -     -                                                                                                         
    SP5:              -           -           -     -     -                                                                                                         

    ExUns: 15c · 15d ^ 16a · 16b · 16c
    SP1:                              
    SP2:  -     -                     
    SP3:  -     -                     
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for RCOR3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCOR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATATAGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RCOR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCOR3

    SOURCE GeneReport for Unigene cluster: Hs.356399
        SABiosciences Custom PCR Arrays for RCOR3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCOR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RCOR3 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RCOR31 REST corepressor 3 87.9(n)
    96.7(a)
      421380  NM_001079727.1  NP_001073195.1 
    lizard
    (Anolis carolinensis)
    Reptilia RCOR36
    --
    87(a)
    1 ↔ 1
    1(237824791-237847434)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5638081 similar to KIAA1343 protein 71.28(n)
    78.13(a)
      563808  NM_001045029.1  NP_001038494.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CoRest6
    CoRest
    21(a)
    1 → many
    X(19415962-19424929)
    worm
    (Caenorhabditis elegans)
    Secernentea Y74C9A.46
    spr-16
    REST corepressor spr-1
    14(a)
    13(a)
    possible ortholog
    possible ortholog
    I(17483-26781)
    V(8126643-8129332)


    ENSEMBL Gene Tree for RCOR3 (if available)
    TreeFam Gene Tree for RCOR3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RCOR3 gene
    NCOR12  RCOR22  RCOR12  NCOR22  
    8 SIMAP similar genes for RCOR3 using alignment to 8 protein entries:     RCOR3_HUMAN (see all proteins):
    RCOR1    RCOR2    FAM138A    FAM138B    FAM138C    FAM138D
    FAM138F    KIAA1651

    RCOR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/942 NCBI SNPs in RCOR3 are shown (see all 942    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354260131,2
    C,F,--211430728(+) TTCTTC/TTCCTA 3 -- us2k110Minor allele frequency- T:0.46NA WA CSA EA 372
    rs802057871,2
    F,--211430781(+) TGCTCG/AAATGG 3 -- us2k12Minor allele frequency- A:0.04NA EA 240
    rs1166348871,2
    --211430809(+) GGTTTT/GACTAA 3 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1864101991,2
    --211430851(+) TCCAAC/TGTTTT 3 -- us2k10--------
    rs1897100841,2
    --211430870(+) ATCTAC/TATGCA 3 -- us2k10--------
    rs1411219781,2
    --211430954(+) CAGAGC/TGAGGA 3 -- us2k10--------
    rs67007471,2
    C,F,A,H,--211431105(+) ATTTCA/CTTTGG 3 -- us2k123Minor allele frequency- C:0.40NS EA NA WA CSA 2348
    rs1451667641,2
    --211431116(+) CCAGGA/GCATTC 3 -- us2k10--------
    rs1475828221,2
    --211431129(+) TCCTTG/TTAGGA 3 -- us2k10--------
    rs747147291,2
    F,--211431263(+) AGACTA/CTCTCT 3 -- us2k12Minor allele frequency- C:0.04NA EA 240

    HapMap Linkage Disequilibrium report for RCOR3 (211431719 - 211489727 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RCOR3
         1 CNV: 5547
         1 Indel: 59975

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RCOR3
    DNA2.0 Custom Variant and Variant Library Synthesis for RCOR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RCOR3 for disorders           About GeneDecksing

    2 diseases for RCOR3:    About MalaCards
    hepatitis b    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: RCOR3 (1 document)

    Export disorders for RCOR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCOR3 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with RCOR3)
        Utopia: connect your pdf to the dynamic
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    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. Involvement of REST corepressor 3 in prognosis of hum an hepatitis B. (PubMed id 21765449)1 Xue J.H....Chen F. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55758 HGNC: 25594 AceView: RCOR3 Ensembl:ENSG00000117625 euGenes: HUgn55758
    ECgene: RCOR3 H-InvDB: RCOR3

    (According to HUGE)
    About This Section
    HUGE: KIAA1343

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCOR3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RCOR3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RCOR3 gene:
    Search GeneIP for patents involving RCOR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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