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Aliases for RCOR2 Gene

Aliases for RCOR2 Gene

  • REST Corepressor 2 2 3 5

External Ids for RCOR2 Gene

Previous GeneCards Identifiers for RCOR2 Gene

  • GC11M063455
  • GC11M063435
  • GC11M063678
  • GC11M060007

Summaries for RCOR2 Gene

GeneCards Summary for RCOR2 Gene

RCOR2 (REST Corepressor 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is RCOR3.

UniProtKB/Swiss-Prot for RCOR2 Gene

  • May act as a component of a corepressor complex that represses transcription.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCOR2 Gene

Genomics for RCOR2 Gene

Regulatory Elements for RCOR2 Gene

Enhancers for RCOR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G064267 1.4 ENCODE dbSUPER 11.1 -353.9 -353856 7.2 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MCM3 NFYC ZFPL1 TRMT112 PLCB3 POLA2 LOC102723878 TRPT1 ENSG00000257086 KCNK4 DNAJC4 ESRRA
GH11G064640 0.9 dbSUPER 11.1 -724.7 -724745 3.0 PKNOX1 ZSCAN4 YBX1 FEZF1 ZNF335 GLIS2 ZNF366 ZNF207 EGR2 ZNF680 KCNK4 RCOR2 C11orf95 PPP2R5B RTN3 NRXN2 GC11M064637 ENSG00000237410 GC11M064638
GH11G063915 1.7 FANTOM5 ENCODE dbSUPER 4.1 -1.6 -1623 6.1 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 FEZF1 SP5 MXD4 OTUB1 RCOR2 LGALS12 GC11M063921
GH11G064793 0.7 ENCODE 9.9 -877.2 -877202 1.8 ZFP64 ZNF140 ZNF266 ZNF101 ZNF697 ZNF664 ZNF654 ZNF426 ZBTB8A ZNF394 C11orf84 CDC42BPG DPF2 EHD1 PLCB3 ENSG00000257086 KAT5 RCOR2 ZFPL1 MEN1
GH11G064372 1.5 FANTOM5 Ensembl ENCODE 4.5 -456.6 -456572 1.3 AGO1 CHAMP1 GLIS2 ZNF138 FOS ZNF263 SP3 NFYA USF2 NFYC LOC102723878 NRXN2 RCOR2 KCNK4 NAA40 GPR137 CDC42BPG MIR1237 GC11M064381
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RCOR2 on UCSC Golden Path with GeneCards custom track

Promoters for RCOR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040588 -156 1201 HDGF ARID4B SIN3A DMAP1 GLIS2 REST SMARCA4 GLIS1 MXD3 NR2C1

Genomic Location for RCOR2 Gene

Chromosome:
11
Start:
63,911,221 bp from pter
End:
63,916,844 bp from pter
Size:
5,624 bases
Orientation:
Minus strand

Genomic View for RCOR2 Gene

Genes around RCOR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCOR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCOR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCOR2 Gene

Proteins for RCOR2 Gene

  • Protein details for RCOR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ40-RCOR2_HUMAN
    Recommended name:
    REST corepressor 2
    Protein Accession:
    Q8IZ40
    Secondary Accessions:
    • Q96FP3

    Protein attributes for RCOR2 Gene

    Size:
    523 amino acids
    Molecular mass:
    58012 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH10608.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

neXtProt entry for RCOR2 Gene

Post-translational modifications for RCOR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RCOR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RCOR2 Gene

Domains & Families for RCOR2 Gene

Gene Families for RCOR2 Gene

Protein Domains for RCOR2 Gene

Suggested Antigen Peptide Sequences for RCOR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZ40

UniProtKB/Swiss-Prot:

RCOR2_HUMAN :
  • Belongs to the CoREST family.
Family:
  • Belongs to the CoREST family.
genes like me logo Genes that share domains with RCOR2: view

Function for RCOR2 Gene

Molecular function for RCOR2 Gene

UniProtKB/Swiss-Prot Function:
May act as a component of a corepressor complex that represses transcription.

Gene Ontology (GO) - Molecular Function for RCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0003714 transcription corepressor activity IBA --
GO:0008134 transcription factor binding IBA --
GO:0019899 enzyme binding IEA --
genes like me logo Genes that share ontologies with RCOR2: view
genes like me logo Genes that share phenotypes with RCOR2: view

Animal Model Products

CRISPR Products

miRNA for RCOR2 Gene

miRTarBase miRNAs that target RCOR2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RCOR2 Gene

Localization for RCOR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCOR2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RCOR2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005667 transcription factor complex IBA --
GO:0017053 transcriptional repressor complex IBA --
genes like me logo Genes that share ontologies with RCOR2: view

Pathways & Interactions for RCOR2 Gene

SuperPathways for RCOR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with RCOR2: view

No data available for Pathways by source and SIGNOR curated interactions for RCOR2 Gene

Drugs & Compounds for RCOR2 Gene

No Compound Related Data Available

Transcripts for RCOR2 Gene

mRNA/cDNA for RCOR2 Gene

Unigene Clusters for RCOR2 Gene

REST corepressor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCOR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for RCOR2 Gene

GeneLoc Exon Structure for
RCOR2
ECgene alternative splicing isoforms for
RCOR2

Expression for RCOR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RCOR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RCOR2 Gene

This gene is overexpressed in Heart (32.3) and Fetal Brain (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RCOR2 Gene



Protein tissue co-expression partners for RCOR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RCOR2 Gene:

RCOR2

SOURCE GeneReport for Unigene cluster for RCOR2 Gene:

Hs.98788

Evidence on tissue expression from TISSUES for RCOR2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RCOR2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RCOR2 Gene

Orthologs for RCOR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCOR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RCOR2 34 35
  • 97.87 (n)
cow
(Bos Taurus)
Mammalia RCOR2 34 35
  • 92.48 (n)
dog
(Canis familiaris)
Mammalia RCOR2 34 35
  • 92.35 (n)
mouse
(Mus musculus)
Mammalia Rcor2 34 16 35
  • 89 (n)
rat
(Rattus norvegicus)
Mammalia Rcor2 34
  • 88.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RCOR2 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RCOR2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rcor2 34
  • 66.12 (n)
Str.20516 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7678 34
zebrafish
(Danio rerio)
Actinopterygii rcor2 34 35
  • 63.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta CoRest 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rcor-1 35
  • 14 (a)
ManyToMany
spr-1 35
  • 14 (a)
ManyToMany
Species where no ortholog for RCOR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCOR2 Gene

ENSEMBL:
Gene Tree for RCOR2 (if available)
TreeFam:
Gene Tree for RCOR2 (if available)

Paralogs for RCOR2 Gene

Paralogs for RCOR2 Gene

(2) SIMAP similar genes for RCOR2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RCOR2 Gene

genes like me logo Genes that share paralogs with RCOR2: view

Variants for RCOR2 Gene

Sequence variations from dbSNP and Humsavar for RCOR2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000242364 -- 63,912,822(+) CTGCC(A/T)CCAGA intron-variant
rs1001502456 -- 63,917,440(+) CCCAC(A/G)CGCAC upstream-variant-2KB
rs1002156863 -- 63,912,405(+) CTCCC(-/A)ATTCC intron-variant, reference, frameshift-variant
rs1002598884 -- 63,917,151(+) CGCTC(C/T)TCGCG upstream-variant-2KB
rs1002656561 -- 63,915,871(+) GCCAA(A/G)CAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCOR2 Gene

Variant ID Type Subtype PubMed ID
esv2660413 CNV deletion 23128226
nsv1070465 CNV deletion 25765185
nsv555180 CNV loss 21841781
nsv555181 CNV loss 21841781
nsv951009 CNV deletion 24416366

Variation tolerance for RCOR2 Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RCOR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RCOR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCOR2 Gene

Disorders for RCOR2 Gene

Relevant External Links for RCOR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RCOR2

No disorders were found for RCOR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCOR2 Gene

Publications for RCOR2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. The functional interactome landscape of the human histone deacetylase family. (PMID: 23752268) Joshi P. … Cristea I.M. (Mol. Syst. Biol. 2013) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for RCOR2 Gene

Sources for RCOR2 Gene

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