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Aliases for RCOR2 Gene

Aliases for RCOR2 Gene

  • REST Corepressor 2 2 3

External Ids for RCOR2 Gene

Previous GeneCards Identifiers for RCOR2 Gene

  • GC11M063455
  • GC11M063435
  • GC11M063678
  • GC11M060007

Summaries for RCOR2 Gene

GeneCards Summary for RCOR2 Gene

RCOR2 (REST Corepressor 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is RCOR3.

UniProtKB/Swiss-Prot for RCOR2 Gene

  • May act as a component of a corepressor complex that represses transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCOR2 Gene

Genomics for RCOR2 Gene

Regulatory Elements for RCOR2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RCOR2 Gene

63,911,221 bp from pter
63,916,935 bp from pter
5,715 bases
Minus strand

Genomic View for RCOR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RCOR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCOR2 Gene

Proteins for RCOR2 Gene

  • Protein details for RCOR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    REST corepressor 2
    Protein Accession:
    Secondary Accessions:
    • Q96FP3

    Protein attributes for RCOR2 Gene

    523 amino acids
    Molecular mass:
    58012 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH10608.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

neXtProt entry for RCOR2 Gene

Proteomics data for RCOR2 Gene at MOPED

Post-translational modifications for RCOR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RCOR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RCOR2 Gene

Domains for RCOR2 Gene

Gene Families for RCOR2 Gene

Protein Domains for RCOR2 Gene

Suggested Antigen Peptide Sequences for RCOR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ELM2 domain.
  • Belongs to the CoREST family.
  • Contains 1 ELM2 domain.
  • Contains 2 SANT domains.
  • Belongs to the CoREST family.
genes like me logo Genes that share domains with RCOR2: view

Function for RCOR2 Gene

Molecular function for RCOR2 Gene

UniProtKB/Swiss-Prot Function:
May act as a component of a corepressor complex that represses transcription.

Gene Ontology (GO) - Molecular Function for RCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RCOR2: view

Phenotypes for RCOR2 Gene

MGI mutant phenotypes for RCOR2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with RCOR2: view

Animal Model Products

miRNA for RCOR2 Gene

miRTarBase miRNAs that target RCOR2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RCOR2 Gene

Localization for RCOR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCOR2 Gene

Subcellular locations from

Jensen Localization Image for RCOR2 Gene COMPARTMENTS Subcellular localization image for RCOR2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with RCOR2: view

Pathways for RCOR2 Gene

SuperPathways for RCOR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with RCOR2: view

No data available for Pathways by source for RCOR2 Gene

Transcripts for RCOR2 Gene

mRNA/cDNA for RCOR2 Gene

Unigene Clusters for RCOR2 Gene

REST corepressor 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RCOR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCOR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -

Relevant External Links for RCOR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RCOR2 Gene

mRNA expression in normal human tissues for RCOR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RCOR2 Gene

This gene is overexpressed in Heart (32.3) and Fetal Brain (31.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RCOR2 Gene

SOURCE GeneReport for Unigene cluster for RCOR2 Gene Hs.98788

genes like me logo Genes that share expressions with RCOR2: view

Expression partners for RCOR2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RCOR2 Gene

Orthologs for RCOR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCOR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RCOR2 35
  • 92.48 (n)
  • 97.71 (a)
RCOR2 36
  • 98 (a)
(Canis familiaris)
Mammalia RCOR2 35
  • 92.35 (n)
  • 97.13 (a)
RCOR2 36
  • 96 (a)
(Mus musculus)
Mammalia Rcor2 35
  • 89 (n)
  • 97.49 (a)
Rcor2 16
Rcor2 36
  • 97 (a)
(Pan troglodytes)
Mammalia RCOR2 35
  • 97.87 (n)
  • 97.49 (a)
RCOR2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rcor2 35
  • 88.91 (n)
  • 97.51 (a)
(Ornithorhynchus anatinus)
Mammalia RCOR2 36
  • 78 (a)
(Anolis carolinensis)
Reptilia RCOR2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rcor2 35
  • 66.12 (n)
  • 67.3 (a)
Str.20516 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7678 35
(Danio rerio)
Actinopterygii rcor2 35
  • 63.99 (n)
  • 63.93 (a)
rcor2 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CoRest 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea rcor-1 36
  • 14 (a)
spr-1 36
  • 14 (a)
Species with no ortholog for RCOR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCOR2 Gene

Gene Tree for RCOR2 (if available)
Gene Tree for RCOR2 (if available)

Paralogs for RCOR2 Gene

Paralogs for RCOR2 Gene

(2) SIMAP similar genes for RCOR2 Gene using alignment to 2 proteins: Pseudogenes for RCOR2 Gene

genes like me logo Genes that share paralogs with RCOR2: view

Variants for RCOR2 Gene

Sequence variations from dbSNP and Humsavar for RCOR2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs320108 - 63,911,897(+) AGGGG(C/T)TCCAA reference, missense
rs578247106 -- 63,913,361(+) TTGTA(-/T)TTTTT intron-variant
rs578231531 -- 63,917,139(+) TCCGC(C/T)GCCGC upstream-variant-2KB
rs577816771 -- 63,915,618(+) TGTGG(A/T)GCCAG intron-variant
rs576890938 -- 63,913,851(+) GGGCT(C/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCOR2 Gene

Variant ID Type Subtype PubMed ID
dgv1155n71 CNV Loss 21882294
dgv1156n71 CNV Loss 21882294
dgv1157n71 CNV Loss 21882294
nsv897634 CNV Loss 21882294
dgv1158n71 CNV Loss 21882294
esv2660413 CNV Deletion 23128226

Relevant External Links for RCOR2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCOR2 Gene

Disorders for RCOR2 Gene

No disorders were found for RCOR2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RCOR2 Gene

Publications for RCOR2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. (PMID: 19394292) Ouyang J. … Gill G. (Mol. Cell 2009) 3
  5. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. (PMID: 21258344) Bantscheff M. … Drewes G. (Nat. Biotechnol. 2011) 3

Products for RCOR2 Gene

Sources for RCOR2 Gene

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