Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RCOR2 Gene

Aliases for RCOR2 Gene

  • REST Corepressor 2 2 3 5

External Ids for RCOR2 Gene

Previous GeneCards Identifiers for RCOR2 Gene

  • GC11M063455
  • GC11M063435
  • GC11M063678
  • GC11M060007

Summaries for RCOR2 Gene

GeneCards Summary for RCOR2 Gene

RCOR2 (REST Corepressor 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is NCOR1.

UniProtKB/Swiss-Prot for RCOR2 Gene

  • May act as a component of a corepressor complex that represses transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCOR2 Gene

Genomics for RCOR2 Gene

Regulatory Elements for RCOR2 Gene

Enhancers for RCOR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RCOR2 on UCSC Golden Path with GeneCards custom track

Promoters for RCOR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RCOR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RCOR2 Gene

Chromosome:
11
Start:
63,911,221 bp from pter
End:
63,916,844 bp from pter
Size:
5,624 bases
Orientation:
Minus strand

Genomic View for RCOR2 Gene

Genes around RCOR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCOR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCOR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCOR2 Gene

Proteins for RCOR2 Gene

  • Protein details for RCOR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ40-RCOR2_HUMAN
    Recommended name:
    REST corepressor 2
    Protein Accession:
    Q8IZ40
    Secondary Accessions:
    • Q96FP3

    Protein attributes for RCOR2 Gene

    Size:
    523 amino acids
    Molecular mass:
    58012 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH10608.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

neXtProt entry for RCOR2 Gene

Proteomics data for RCOR2 Gene at MOPED

Post-translational modifications for RCOR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RCOR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RCOR2 Gene

Domains & Families for RCOR2 Gene

Gene Families for RCOR2 Gene

Protein Domains for RCOR2 Gene

Suggested Antigen Peptide Sequences for RCOR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZ40

UniProtKB/Swiss-Prot:

RCOR2_HUMAN :
  • Contains 1 ELM2 domain.
  • Belongs to the CoREST family.
Domain:
  • Contains 1 ELM2 domain.
  • Contains 2 SANT domains.
Family:
  • Belongs to the CoREST family.
genes like me logo Genes that share domains with RCOR2: view

Function for RCOR2 Gene

Molecular function for RCOR2 Gene

UniProtKB/Swiss-Prot Function:
May act as a component of a corepressor complex that represses transcription.

Gene Ontology (GO) - Molecular Function for RCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with RCOR2: view
genes like me logo Genes that share phenotypes with RCOR2: view

Animal Models for RCOR2 Gene

MGI Knock Outs for RCOR2:

Animal Model Products

miRNA for RCOR2 Gene

miRTarBase miRNAs that target RCOR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RCOR2 Gene

Localization for RCOR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCOR2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RCOR2 Gene COMPARTMENTS Subcellular localization image for RCOR2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for RCOR2 Gene

Pathways & Interactions for RCOR2 Gene

SuperPathways for RCOR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RCOR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RCOR2 Gene

Drugs & Compounds for RCOR2 Gene

No Compound Related Data Available

Transcripts for RCOR2 Gene

mRNA/cDNA for RCOR2 Gene

Unigene Clusters for RCOR2 Gene

REST corepressor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RCOR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for RCOR2 Gene

GeneLoc Exon Structure for
RCOR2
ECgene alternative splicing isoforms for
RCOR2

Expression for RCOR2 Gene

mRNA expression in normal human tissues for RCOR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RCOR2 Gene

This gene is overexpressed in Heart (32.3) and Fetal Brain (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RCOR2 Gene



SOURCE GeneReport for Unigene cluster for RCOR2 Gene Hs.98788

genes like me logo Genes that share expression patterns with RCOR2: view

Protein tissue co-expression partners for RCOR2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RCOR2 Gene

Orthologs for RCOR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCOR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RCOR2 35
  • 92.48 (n)
  • 97.71 (a)
RCOR2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RCOR2 35
  • 92.35 (n)
  • 97.13 (a)
RCOR2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rcor2 35
  • 89 (n)
  • 97.49 (a)
Rcor2 16
Rcor2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RCOR2 35
  • 97.87 (n)
  • 97.49 (a)
RCOR2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rcor2 35
  • 88.91 (n)
  • 97.51 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia RCOR2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RCOR2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rcor2 35
  • 66.12 (n)
  • 67.3 (a)
Str.20516 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7678 35
zebrafish
(Danio rerio)
Actinopterygii rcor2 35
  • 63.99 (n)
  • 63.93 (a)
rcor2 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CoRest 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rcor-1 36
  • 14 (a)
ManyToMany
spr-1 36
  • 14 (a)
ManyToMany
Species with no ortholog for RCOR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCOR2 Gene

ENSEMBL:
Gene Tree for RCOR2 (if available)
TreeFam:
Gene Tree for RCOR2 (if available)

Paralogs for RCOR2 Gene

Paralogs for RCOR2 Gene

(2) SIMAP similar genes for RCOR2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RCOR2 Gene

genes like me logo Genes that share paralogs with RCOR2: view

Variants for RCOR2 Gene

Sequence variations from dbSNP and Humsavar for RCOR2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs320108 - 63,911,897(+) AGGGG(C/T)TCCAA reference, missense
rs112110782 -- 63,916,919(+) GGGGA(A/C)CCGTG upstream-variant-2KB
rs12269937 -- 63,912,226(+) CCTCA(A/G)CCCAG intron-variant
rs12271405 -- 63,912,580(+) AACTA(A/G)TTACT intron-variant
rs112400764 -- 63,913,032(+) GCACA(A/G)ACACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCOR2 Gene

Variant ID Type Subtype PubMed ID
dgv1155n71 CNV Loss 21882294
dgv1156n71 CNV Loss 21882294
dgv1157n71 CNV Loss 21882294
nsv897634 CNV Loss 21882294
dgv1158n71 CNV Loss 21882294
esv2660413 CNV Deletion 23128226

Variation tolerance for RCOR2 Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RCOR2 Gene

Disorders for RCOR2 Gene

Relevant External Links for RCOR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RCOR2

No disorders were found for RCOR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCOR2 Gene

Publications for RCOR2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The functional interactome landscape of the human histone deacetylase family. (PMID: 23752268) Joshi P. … Cristea I.M. (Mol. Syst. Biol. 2013) 3
  5. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. (PMID: 21258344) Bantscheff M. … Drewes G. (Nat. Biotechnol. 2011) 3

Products for RCOR2 Gene

Sources for RCOR2 Gene

Content