Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCOR2 Gene

protein-coding   GIFtS: 48
GCID: GC11M063678

REST Corepressor 2

Microbiology & Infectious Diseases Congress
  Search for RCOR2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
REST Corepressor 21 2

External Ids:    HGNC: 274551   Entrez Gene: 2832482   Ensembl: ENSG000001677717   UniProtKB: Q8IZ403   

Export aliases for RCOR2 gene to outside databases

Previous GC identifers: GC11M063455 GC11M063435 GC11M060007


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RCOR2 Gene: 
RCOR2 (REST corepressor 2) is a protein-coding gene. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RCOR1.

UniProtKB/Swiss-Prot: RCOR2_HUMAN, Q8IZ40
Function: May act as a component of a corepressor complex that represses transcription (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCOR2 gene promoter:
         E2F-4   E2F-3a   NF-1/L   E2F-5   E2F-2   GATA-2   Egr-4   HEN1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRCOR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RCOR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCOR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

RCOR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCOR2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M063678:  view genomic region     (about GC identifiers)

Start:
63,678,693 bp from pter      End:
63,684,316 bp from pter
Size:
5,624 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RCOR2_HUMAN, Q8IZ40 (See protein sequence)
Recommended Name: REST corepressor 2  
Size: 523 amino acids; 58012 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAH10608.1; Type=Miscellaneous discrepancy; Note=Chimera;
Secondary accessions: Q96FP3

Explore the universe of human proteins at neXtProt for RCOR2: NX_Q8IZ40

Explore proteomics data for RCOR2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZ40

  • RCOR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RCOR2 Protein Expression
    REFSEQ proteins: NP_775858.2  
    ENSEMBL proteins: 
     ENSP00000301459  

    Human Recombinant Protein Products for RCOR2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RCOR2
    GenScript Custom Purified and Recombinant Proteins Services for RCOR2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RCOR2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--

    RCOR2 for ontologies           About GeneDecksing



    RCOR2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RCOR2
    GenScript Custom Superior Antibodies Services for RCOR2
    Novus Biologicals RCOR2 Antibodies
    Abcam antibodies for RCOR2
    Cloud-Clone Corp. Antibodies for RCOR2 
    Search ThermoFisher Antibodies for RCOR2
    LSBio Antibodies in human, mouse, rat for RCOR2 

    Assay Products for RCOR2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RCOR2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RCOR2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RCOR2 
    Cloud-Clone Corp. CLIAs for RCOR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR000949 ELM2_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q8IZ40

    ProtoNet protein and cluster: Q8IZ40

    1 Blocks protein domain: IPB001005 Myb DNA-binding domain

    UniProtKB/Swiss-Prot: RCOR2_HUMAN, Q8IZ40
    Similarity: Belongs to the CoREST family
    Similarity: Contains 1 ELM2 domain
    Similarity: Contains 2 SANT domains


    RCOR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RCOR2_HUMAN, Q8IZ40
    Function: May act as a component of a corepressor complex that represses transcription (Potential)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding ----
         
    RCOR2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rcor2):
     cellular 

    RCOR2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RCOR2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RCOR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RCOR2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RCOR2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCOR2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate RCOR2:
    hsa-miR-515-5p hsa-miR-2114 hsa-miR-137 hsa-miR-1237 hsa-miR-654-3p hsa-miR-3127-5p hsa-miR-3182 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidRCOR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RCOR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCOR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RCOR2
    Sirion Biotech Customized adenovirus for overexpression of RCOR2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RCOR2 (see all 5)
    OriGene ORF clones in mouse, rat for RCOR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RCOR2 (NM_173587)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCOR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCOR2
    Sirion Biotech Customized lentivirus for stable overexpression of RCOR2 
                         Customized lentivirus expression plasmids for stable overexpression of RCOR2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RCOR2
    Search LifeMap BioReagents cell lines for RCOR2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCOR2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RCOR2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/16 Interacting proteins for RCOR2 (Q8IZ402, 3 ENSP000003014594) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    ENSG00000233911Q018603I2D: score=2 
    ENSG00000235068Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IEA--

    RCOR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCOR2

    Search CenterWatch for drugs/clinical trials and news about RCOR2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RCOR2 gene: 
    NM_173587.3  

    Unigene Cluster for RCOR2:

    REST corepressor 2
    Hs.98788  [show with all ESTs]
    Unigene Representative Sequence: AB593132
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301459(uc001nyc.3) ENST00000489217 ENST00000473926
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RCOR2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate RCOR2:
    hsa-miR-515-5p hsa-miR-2114 hsa-miR-137 hsa-miR-1237 hsa-miR-654-3p hsa-miR-3127-5p hsa-miR-3182 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidRCOR2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RCOR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCOR2
    Clone
    Products:
         
    OriGene clones in human, mouse for RCOR2 (see all 5)
    OriGene ORF clones in mouse, rat for RCOR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RCOR2 (NM_173587)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCOR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCOR2
    Sirion Biotech Customized lentivirus for stable overexpression of RCOR2 
                         Customized lentivirus expression plasmids for stable overexpression of RCOR2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RCOR2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RCOR2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCOR2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCOR2

    Additional mRNA sequence: 

    AB593132.1 BC023587.2 

    4 DOTS entries:

    DT.103705  DT.99942876  DT.100748510  DT.100748509 

    24/52 AceView cDNA sequences (see all 52):

    AA338543 BF528119 BF944639 NM_173587 BM682108 BM680417 BM683018 BQ880948 
    BU147399 BM678625 BC023587 BU197375 AW444628 AI962660 BQ083039 BM765466 
    BU856438 BI914592 BM719037 BX099823 BM721004 BU146308 BE673051 BQ083031 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RCOR2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:                                            -                                                               
    SP2:                                            -                                                               
    SP3:                                            -                                                               
    SP4:                                            -                                                               
    SP5:                                                                                            -               


    ECgene alternative splicing isoforms for RCOR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCOR2 expression in normal human tissues (normalized intensities)      RCOR2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTATTTT
    RCOR2 Expression
    About this image


    RCOR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   
     
     Blood Brain Barrier (Nervous System)
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Inner Cell Mass (Early Embryonic Tissues)
             ESI-049   
     
     Bone (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   

    See RCOR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCOR2

    SOURCE GeneReport for Unigene cluster: Hs.98788
        SABiosciences Custom PCR Arrays for RCOR2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RCOR2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RCOR2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCOR2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCOR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCOR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RCOR2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rcor21 , 5 REST corepressor 21, 5 89(n)1
    97.49(a)1
      19 (5.32 cM)5
    1043831  NM_054048.31  NP_473389.11 
     72673255 
    lizard
    (Anolis carolinensis)
    Reptilia RCOR26
    REST corepressor 2
    74(a)
    1 ↔ 1
    GL343699.1(201655-222968)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76782 Xenopus laevis transcribed sequence with weak similarity more 75.87(n)    BU913354.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rcor21 REST corepressor 2 65.12(n)
    66.33(a)
      402934  NM_205638.1  NP_991201.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CoRest1 CG42687-PA 50.65(n)
    38.06(a)
      32941  NM_001201742.2  NP_001188671.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNT16
    Subunit of the Set3C deacetylase complex that inte...
    5(a)
    1 → many
    III(186489-190169)


    ENSEMBL Gene Tree for RCOR2 (if available)
    TreeFam Gene Tree for RCOR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RCOR2 gene
    RCOR12  RCOR32  
    2 SIMAP similar genes for RCOR2 using alignment to 2 protein entries:     RCOR2_HUMAN (see all proteins):
    RCOR3    RCOR1

    RCOR2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RCOR2
    PGOHUM00000239895


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/200 SNPs in RCOR2 are shown (see all 200)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817204361,2
    --63679227(+) CTTACA/CAAGAC 1 -- ut310--------
    rs3201081,2,4
    C,F,A,H--63679369(+) AGGGGC/TTCCAA 2 T A mis110Minor allele frequency- T:0.06NA CSA WA EA 254
    rs2014807501,2
    C--63679691(+) TTCCCA/GCCCTC 1 -- int10--------
    rs2010117681,2
    --63679727(+) GCCTCA/GCCTCG 1 -- int10--------
    rs2003922411,2
    C--63679736(+) CGCCTC/TGCCTC 1 -- int10--------
    rs1871490941,2
    C--63679739(+) CTCGCC/TTCTCC 1 -- int10--------
    rs2020077751,2
    C--63679828(+) CTAGCC/TTCCTC 2 E syn11Minor allele frequency- T:0.00EU 1321
    rs2022269171,2
    C--63679829(+) TAGCCG/TCCTCC 2 E A mis10--------
    rs1443689851,2
    C,F--63679947(+) GGTCAG/CAGTCT 2 /L /V mis12Minor allele frequency- C:0.00NA EU 4951
    rs1466987771,2
    C--63679988(+) AGTCTC/TTGCCA 2 K R mis10--------

    HapMap Linkage Disequilibrium report for RCOR2 (63678693 - 63684316 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RCOR2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660413CNV Deletion23128226
    dgv1156n71CNV Loss21882294
    dgv1157n71CNV Loss21882294
    dgv1155n71CNV Loss21882294
    dgv1158n71CNV Loss21882294
    nsv897634CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RCOR2
    DNA2.0 Custom Variant and Variant Library Synthesis for RCOR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCOR2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with RCOR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    4. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (2011)
    5. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. (PubMed id 21258344)1 Bantscheff M....Drewes G. (2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. Activation of HIV transcription by the viral Tat prote in requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1 /KDM1). (PubMed id 21876670)1 Sakane N....Ott M. (2011)
    8. RCOR2 is a subunit of the LSD1 complex that regulates ESC property and substitutes for SOX2 in reprogramming somatic cells to plurip otency. (PubMed id 21433225)1 Yang P....Gao S. (2011)
    9. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. (PubMed id 19394292)1 Ouyang J....Gill G. (2009)
    10. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283248 HGNC: 27455 AceView: RCOR2 Ensembl:ENSG00000167771 euGenes: HUgn283248
    ECgene: RCOR2 H-InvDB: RCOR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCOR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RCOR2 gene:
    Search GeneIP for patents involving RCOR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RCOR2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RCOR2  
     OriGene qSTAR qPCR primer pairs in human, mouse for RCOR2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RCOR2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RCOR2   OriGene Custom Protein Services for RCOR2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RCOR2
     QIAGEN SeqTarget long-range PCR primers for resequencing RCOR2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCOR2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RCOR2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RCOR2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RCOR2
     GenScript Custom Purified and Recombinant Proteins Services for RCOR2 GenScript cDNA clones with any tag delivered in your preferred vector for RCOR2
     GenScript Custom Assay Services for RCOR2 GenScript Custom Superior Antibodies Services for RCOR2
     GenScript Custom overexpressing Cell Line Services for RCOR2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RCOR2 promoter
     Search Chromatin IP Primers for RCOR2
     RT2 qPCR Primer Assay in human, mouse, rat RCOR2
     Search GNC Networks for RCOR2
     SABiosciences Custom PCR Arrays for RCOR2
     Search Tocris compounds for RCOR2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RCOR2 antibodies
     Antibodies for RCOR2
     See all of Abcam's Antibodies, Kits and Proteins for RCOR2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RCOR2
     Antibodies for RCOR2
     ELISAs for RCOR2
     CLIAs for RCOR2
     Search LifeMap BioReagents cell lines for RCOR2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCOR2
     SwitchGear 3'UTR luciferase reporter plasmids for RCOR2
     SwitchGear Promoter luciferase reporter plasmids for RCOR2
     Search ThermoFisher Antibodies for RCOR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCOR2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RCOR2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RCOR2
    Customized:
     lentivirus for stable overexpression of RCOR2
     lentivirus expression plasmids for stable overexpression of RCOR2
     adenovirus for overexpression of RCOR2
     LSBio Antibodies in human, mouse, rat for RCOR2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RCOR2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4