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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RCOR2 Gene

protein-coding   GIFtS: 45
GCID: GC11M063678

REST corepressor 2
  Search for RCOR2
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RCOR2    

Aliases
for RCOR2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
REST Corepressor 21 2

External Ids:    HGNC: 274551   Entrez Gene: 2832482   Ensembl: ENSG000001677717   UniProtKB: Q8IZ403   

Export aliases for RCOR2 gene to outside databases

Previous GC identifers: GC11M063455 GC11M063435 GC11M060007


Summaries
for RCOR2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RCOR2_HUMAN, Q8IZ40
Function: May act as a component of a corepressor complex that represses transcription (Potential)




Genomic Views
for RCOR2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RCOR2 gene promoter:
         E2F-4   E2F-3a   NF-1/L   E2F-5   E2F-2   GATA-2   Egr-4   HEN1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RCOR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RCOR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RCOR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

RCOR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCOR2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M063678:  view genomic region     (about GC identifiers)

Start:
 63,678,693 bp from pter      End:
 63,684,316 bp from pter
Size:
 5,624 bases      Orientation:
 minus strand

Proteins
for RCOR2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RCOR2_HUMAN, Q8IZ40 (See protein sequence)
Recommended Name: REST corepressor 2  
Size: 523 amino acids; 58012 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAH10608.1; Type=Miscellaneous discrepancy; Note=Chimera;
Secondary accessions: Q96FP3

Explore the universe of human proteins at neXtProt for RCOR2: NX_Q8IZ40

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IZ40

    • RCOR2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_775858.2  
    ENSEMBL proteins: 
     ENSP00000301459  

    Human Recombinant Protein Products: 
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    Uscn Proteins for RCOR2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005634nucleus ----
    GO:0005667transcription factor complex IEA--


    RCOR2 for ontologies           About GeneDecksing



    RCOR2 Antibody Products: 
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    Uscn ELISAs and CLIAs for RCOR2

    Protein Domains /
    Families
    for RCOR2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RCOR2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR000949 ELM2_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q8IZ40

    ProtoNet protein and cluster: Q8IZ40

    1 Blocks protein family: IPB001005 Myb DNA-binding domain

    UniProtKB/Swiss-Prot: RCOR2_HUMAN, Q8IZ40
    Similarity: Belongs to the CoREST family
    Similarity: Contains 1 ELM2 domain
    Similarity: Contains 2 SANT domains


    Function
    for RCOR2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RCOR2_HUMAN, Q8IZ40
    Function: May act as a component of a corepressor complex that represses transcription (Potential)

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate RCOR2:
    hsa-miR-515-5p hsa-miR-2114 hsa-miR-137 hsa-miR-1237 hsa-miR-654-3p hsa-miR-3127-5p hsa-miR-3182 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmid: RCOR2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RCOR2 (see all 7)
    OriGene shRNA RFP: RCOR2
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RCOR2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RCOR2 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for RCOR2

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding ----


    RCOR2 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Rcor2):
     cellular 

    RCOR2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RCOR2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RCOR2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/10 Interacting proteins for RCOR2 (Q8IZ402, 3 ENSP000003014594) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARR3P365752, 3, ENSP000003115384MINT-64401 I2D: score=3 STRING: ENSP00000311538
    TAL1P175423, ENSP000002943394I2D: score=1 STRING: ENSP00000294339
    SUMO2P619563, ENSP000004059654I2D: score=1 STRING: ENSP00000405965
    POU5F1Q018603I2D: score=2 
    CTR9Q6PD623I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IEA--


    RCOR2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RCOR2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RCOR2
    Search CenterWatch for drugs/clinical trials and news about RCOR2 

    Transcripts
    for RCOR2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RCOR2 gene: 
    NM_173587.3  

    Unigene Cluster for RCOR2:

    REST corepressor 2
    Hs.98788  [show with all ESTs]
    Unigene Representative Sequence: AB593132
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301459(uc001nyc.3) ENST00000489217 ENST00000473926

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RCOR2
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate RCOR2:
    hsa-miR-515-5p hsa-miR-2114 hsa-miR-137 hsa-miR-1237 hsa-miR-654-3p hsa-miR-3127-5p hsa-miR-3182 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmid: RCOR2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RCOR2 (see all 7)
    OriGene shRNA RFP: RCOR2
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB593132.1 BC023587.2 

    4 DOTS entries:

    DT.103705  DT.99942876  DT.100748510  DT.100748509 

    24/52 AceView cDNA sequences (see all 52):

    BF944639 BM680417 AW444628 BU147399 BQ880948 BF528119 AA338543 BM678625 
    AI962660 BU197375 BM683018 NM_173587 BM682108 BC023587 CA424623 BE673051 
    BM759775 BQ083031 BM724284 CD674152 BG056049 BF530276 BV175556 BM719037 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RCOR2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:                                            -                                                               
    SP2:                                            -                                                               
    SP3:                                            -                                                               
    SP4:                                            -                                                               
    SP5:                                                                                            -               


    ECgene alternative splicing isoforms for RCOR2

    Expression
    for RCOR2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RCOR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATTTATTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RCOR2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RCOR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RCOR2

    SOURCE GeneReport for Unigene cluster: Hs.98788
        SABiosciences Custom PCR Arrays for RCOR2
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    In Situ
    Assay Products:     
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    Orthologs
    for RCOR2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RCOR2 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia RCOR26
    		 --
    		 73(a)
    		 1 ↔ 1
    		 GL343699.1(201682-213400)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.76782 Xenopus laevis transcribed sequence with weak similarity more 75.87(n)    BU913354.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rcor21 REST corepressor 2 65.12(n)
    66.33(a)    		   402934  NM_205638.1  NP_991201.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CoRest1 CG42687-PA 50.65(n)
    38.06(a)    		   32941  NM_001201742.2  NP_001188671.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea spr-16
    Y74C9A.46
    		 Protein Y74C9A.4, isoform b
    		 14(a)
    14(a)
    		 possible ortholog
    possible ortholog
    		 V(8126643-8129332)
    I(17483-26781)


    ENSEMBL Gene Tree for RCOR2 (if available)
    TreeFam Gene Tree for RCOR2 (if available) 

    Paralogs
    for RCOR2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RCOR2 gene
    NCOR12  RCOR12  RCOR32  NCOR22  
    2 SIMAP similar genes for RCOR2 using alignment to 2 protein entries:     RCOR2_HUMAN (see all proteins):
    RCOR3    RCOR1

    RCOR2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RCOR2
    PGOHUM00000239895


    Genomic Variants
    for RCOR2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/123 NCBI SNPs in RCOR2 are shown (see all 123)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1817204361,2
    		--63679227(+) CTTACA/CAAGAC 1 -- ut310--------
    rs3201081,2
    		C,F,A,H,--63679369(+) AGGGGC/TTCCAA 2 T A mis110Minor allele frequency- T:0.06NA CSA WA EA 254
    rs2014807501,2
    		--63679691(+) TTCCCA/GCCCTC 1 -- int10--------
    rs2010117681,2
    		--63679727(+) GCCTCA/GCCTCG 1 -- int10--------
    rs2003922411,2
    		--63679736(+) CGCCTC/TGCCTC 1 -- int10--------
    rs1871490941,2
    		C,--63679739(+) CTCGCC/TTCTCC 1 -- int10--------
    rs2022269171,2
    		--63679829(+) TAGCCG/TCCTCC 2 E A mis10--------
    rs1443689851,2
    		C,F,--63679947(+) GGTCAG/CAGTCT 2 /L /V mis12Minor allele frequency- C:0.00NA EU 4951
    rs1466987771,2
    		C,--63679988(+) AGTCTC/TTGCCA 2 K R mis10--------
    rs1895207581,2
    		C,--63680032(+) GCAGCA/GTCAAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RCOR2 (63678693 - 63684316 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RCOR2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RCOR2
    DNA2.0 Custom Variant and Variant Library Synthesis for RCOR2

    Disorders / Diseases
    for RCOR2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for RCOR2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RCOR2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RCOR2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (2011)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    5. Activation of HIV transcription by the viral Tat prote in requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1 /KDM1). (PubMed id 21876670)1 Sakane N....Ott M. (2011)
    6. RCOR2 is a subunit of the LSD1 complex that regulates ESC property and substitutes for SOX2 in reprogramming somatic cells to plurip otency. (PubMed id 21433225)1 Yang P....Gao S. (2011)
    7. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. (PubMed id 19394292)1 Ouyang J....Gill G. (2009)
    8. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    External Searches for RCOR2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing RCOR2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283248 HGNC: 27455 AceView: RCOR2 Ensembl:ENSG00000167771 euGenes: HUgn283248
    ECgene: RCOR2 H-InvDB: RCOR2

    Other Databases showing RCOR2 gene

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    Specialized Databases showing RCOR2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RCOR2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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