Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RCOR2 Gene

protein-coding   GIFtS: 49
GCID: GC11M063678

REST Corepressor 2

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
REST Corepressor 21 2

External Ids:    HGNC: 274551   Entrez Gene: 2832482   Ensembl: ENSG000001677717   UniProtKB: Q8IZ403   

Export aliases for RCOR2 gene to outside databases

Previous GC identifers: GC11M063455 GC11M063435 GC11M060007


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RCOR2 Gene:
RCOR2 (REST corepressor 2) is a protein-coding gene. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RCOR1.

UniProtKB/Swiss-Prot: RCOR2_HUMAN, Q8IZ40
Function: May act as a component of a corepressor complex that represses transcription (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RCOR2 gene promoter:
         E2F-4   E2F-3a   NF-1/L   E2F-5   E2F-2   GATA-2   Egr-4   HEN1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRCOR2 promoter sequence
   Search Chromatin IP Primers for RCOR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RCOR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

RCOR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RCOR2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M063678:  view genomic region     (about GC identifiers)

Start:
63,678,693 bp from pter      End:
63,684,316 bp from pter
Size:
5,624 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RCOR2_HUMAN, Q8IZ40 (See protein sequence)
Recommended Name: REST corepressor 2  
Size: 523 amino acids; 58012 Da
Sequence caution: Sequence=AAH10608.1; Type=Miscellaneous discrepancy; Note=Chimera;
Secondary accessions: Q96FP3

Explore the universe of human proteins at neXtProt for RCOR2: NX_Q8IZ40

Explore proteomics data for RCOR2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RCOR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775858.2  
    ENSEMBL proteins: 
     ENSP00000301459  

    RCOR2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RCOR2
    GenScript Custom Purified and Recombinant Proteins Services for RCOR2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RCOR2

     
    Search eBioscience for Proteins for RCOR2 

     
    Search antibodies-online for proteins for RCOR2 

     
    antibodies-online peptides for RCOR2

    RCOR2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RCOR2
    Novus Biologicals RCOR2 Antibodies
    Search for Antibodies for RCOR2 at Abcam
    Cloud-Clone Corp. Antibodies for RCOR2
    Search ThermoFisher Antibodies for RCOR2
    antibodies-online antibodies for RCOR2 (13 products) 

    RCOR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RCOR2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RCOR2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RCOR2
    Cloud-Clone Corp. CLIAs for RCOR2
    Search eBioscience for ELISAs for RCOR2 
    antibodies-online kits for RCOR2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR000949 ELM2_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q8IZ40

    ProtoNet protein and cluster: Q8IZ40

    1 Blocks protein domain: IPB001005 Myb DNA-binding domain

    UniProtKB/Swiss-Prot: RCOR2_HUMAN, Q8IZ40
    Similarity: Belongs to the CoREST family
    Similarity: Contains 1 ELM2 domain
    Similarity: Contains 2 SANT domains


    Find genes that share domains with RCOR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RCOR2_HUMAN, Q8IZ40
    Function: May act as a component of a corepressor complex that represses transcription (Potential)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with RCOR2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rcor2):
     cellular 

    Find genes that share phenotypes with RCOR2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RCOR2

    miRNA
    Products:
        
    miRTarBase miRNAs that target RCOR2:
    hsa-mir-1 (MIRT023942)

    Block miRNA regulation of human, mouse, rat RCOR2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate RCOR2:
    hsa-miR-515-5p hsa-miR-2114 hsa-miR-137 hsa-miR-1237 hsa-miR-654-3p hsa-miR-3127-5p hsa-miR-3182 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidRCOR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RCOR2
    Predesigned siRNA for gene silencing in human, mouse, rat RCOR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RCOR2

    Clone
    Products:
         
    OriGene clones in human, mouse for RCOR2 (see all 7)
    OriGene ORF clones in mouse, rat for RCOR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RCOR2 (NM_173587)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCOR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCOR2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RCOR2
    Browse ESI BIO Cell Lines and PureStem Progenitors for RCOR2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCOR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RCOR2_HUMAN, Q8IZ40: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--

    Find genes that share ontologies with RCOR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RCOR2
    Interactions:

        Search GeneGlobe Interaction Network for RCOR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for RCOR2 (Q8IZ402, 3 ENSP000003014594) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603, ENSP000003730164I2D: score=2 STRING: ENSP00000373016
    ENSG00000229094Q018603, ENSP000003888424I2D: score=2 STRING: ENSP00000388842
    ENSG00000230336Q018603, ENSP000004000474I2D: score=2 STRING: ENSP00000400047
    ENSG00000233911Q018603, ENSP000003928774I2D: score=2 STRING: ENSP00000392877
    ENSG00000235068Q018603, ENSP000004050414I2D: score=2 STRING: ENSP00000405041
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0045892negative regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with RCOR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RCOR2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RCOR2 gene: 
    NM_173587.3  

    Unigene Cluster for RCOR2:

    REST corepressor 2
    Hs.98788  [show with all ESTs]
    Unigene Representative Sequence: AB593132
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301459(uc001nyc.3) ENST00000489217 ENST00000473926
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RCOR2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate RCOR2:
    hsa-miR-515-5p hsa-miR-2114 hsa-miR-137 hsa-miR-1237 hsa-miR-654-3p hsa-miR-3127-5p hsa-miR-3182 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidRCOR2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RCOR2
    Predesigned siRNA for gene silencing in human, mouse, rat RCOR2
    Clone
    Products:
         
    OriGene clones in human, mouse for RCOR2 (see all 7)
    OriGene ORF clones in mouse, rat for RCOR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RCOR2 (NM_173587)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RCOR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCOR2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RCOR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RCOR2
      QuantiTect SYBR Green Assays in human, mouse, rat RCOR2
      QuantiFast Probe-based Assays in human, mouse, rat RCOR2

    Additional mRNA sequence: 

    AB593132.1 BC023587.2 

    4 DOTS entries:

    DT.103705  DT.99942876  DT.100748510  DT.100748509 

    Selected AceView cDNA sequences (see all 52):

    AI962660 BM678625 BM682108 BF528119 NM_173587 BM680417 BU197375 AA338543 
    BC023587 BM683018 BQ880948 AW444628 BU147399 BF944639 CA424623 BI914592 
    BQ083031 BG056049 BX099823 BQ083039 BM765466 BM721004 BU856438 AI903098 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RCOR2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:                                            -                                                               
    SP2:                                            -                                                               
    SP3:                                            -                                                               
    SP4:                                            -                                                               
    SP5:                                                                                            -               


    ECgene alternative splicing isoforms for RCOR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RCOR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTATTTT
    RCOR2 Expression
    About this image


    RCOR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
    RCOR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RCOR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98788
        Custom PCR Arrays for RCOR2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RCOR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RCOR2
    QuantiTect SYBR Green Assays in human, mouse, rat RCOR2
    QuantiFast Probe-based Assays in human, mouse, rat RCOR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCOR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RCOR2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rcor21 , 5 REST corepressor 21, 5 89(n)1
    97.49(a)1
      19 (5.32 cM)5
    1043831  NM_054048.31  NP_473389.11 
     72673255 
    lizard
    (Anolis carolinensis)
    Reptilia RCOR26
    REST corepressor 2
    70(a)
    1 ↔ 1
    GL343699.1(201655-222968)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76782 Xenopus laevis transcribed sequence with weak similarity more 75.87(n)    BU913354.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rcor21 REST corepressor 2 63.99(n)
    63.93(a)
      402934  NM_205638.1  NP_991201.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CoRest6
    CoRest
    20(a)
    1 → many
    X(19415962-19424929)
    worm
    (Caenorhabditis elegans)
    Secernentea spr-16
    rcor-16
    Protein SPR-1 (spr-1) mRNA, complete cds
    Protein RCOR-1, isoform a (rcor-1) mRNA, complete ...
    14(a)
    14(a)
    many ↔ many
    many ↔ many
    V(8126663-8129352) WBGene00005006
    I(17483-26781) WBGene00022278


    ENSEMBL Gene Tree for RCOR2 (if available)
    TreeFam Gene Tree for RCOR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RCOR2 gene
    RCOR12  RCOR32  
    2 SIMAP similar genes for RCOR2 using alignment to 2 protein entries:     RCOR2_HUMAN (see all proteins):
    RCOR3    RCOR1

    Find genes that share paralogs with RCOR2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RCOR2
    PGOHUM00000239895


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RCOR2 (see all 200)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817204361,2
    --63679227(+) CTTACA/CAAGAC 1 -- ut310--------
    rs3201081,2,,4
    C,F,A,H--63679369(+) AGGGGC/TTCCAA 2 T A mis110Minor allele frequency- T:0.06NA CSA WA EA 254
    rs2014807501,2
    C--63679691(+) TTCCCA/GCCCTC 1 -- int10--------
    rs2010117681,2
    --63679727(+) GCCTCA/GCCTCG 1 -- int10--------
    rs2003922411,2
    C--63679736(+) CGCCTC/TGCCTC 1 -- int10--------
    rs1871490941,2
    C--63679739(+) CTCGCC/TTCTCC 1 -- int10--------
    rs2020077751,2
    C--63679828(+) CTAGCC/TTCCTC 2 E syn11Minor allele frequency- T:0.00EU 1321
    rs2022269171,2
    C--63679829(+) TAGCCG/TCCTCC 2 E A mis10--------
    rs1443689851,2
    C,F--63679947(+) GGTCAG/CAGTCT 2 /L /V mis12Minor allele frequency- C:0.00NA EU 4951
    rs1466987771,2
    C--63679988(+) AGTCTC/TTGCCA 2 K R mis10--------

    HapMap Linkage Disequilibrium report for RCOR2 (63678693 - 63684316 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RCOR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660413CNV Deletion23128226
    dgv1156n71CNV Loss21882294
    dgv1157n71CNV Loss21882294
    dgv1155n71CNV Loss21882294
    dgv1158n71CNV Loss21882294
    nsv897634CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RCOR2
    DNA2.0 Custom Variant and Variant Library Synthesis for RCOR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RCOR2 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with RCOR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    4. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)
    5. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. (PubMed id 21258344)1 Bantscheff M....Drewes G. (Nat. Biotechnol. 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). (PubMed id 21876670)1 Sakane N....Ott M. (PLoS Pathog. 2011)
    8. RCOR2 is a subunit of the LSD1 complex that regulates ESC property and substitutes for SOX2 in reprogramming somatic cells to pluripotency. (PubMed id 21433225)1 Yang P....Gao S. (Stem Cells 2011)
    9. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. (PubMed id 19394292)1 Ouyang J....Gill G. (Mol. Cell 2009)
    10. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 283248 HGNC: 27455 AceView: RCOR2 Ensembl:ENSG00000167771 euGenes: HUgn283248
    ECgene: RCOR2 H-InvDB: RCOR2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RCOR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RCOR2 gene:
    Search GeneIP for patents involving RCOR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RCOR2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RCOR2  
     OriGene qSTAR qPCR primer pairs in human, mouse for RCOR2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RCOR2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RCOR2   OriGene Custom Protein Services for RCOR2  

     
     
     Block miRNA regulation of human, mouse, rat RCOR2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RCOR2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RCOR2 Predesigned siRNA for gene silencing in human, mouse, rat RCOR2
     QuantiFast Probe-based Assays in human, mouse, rat RCOR2 QuantiTect SYBR Green Assays in human, mouse, rat RCOR2
     Custom PCR Arrays for RCOR2 Search Chromatin IP Primers for RCOR2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RCOR2  Search GeneGlobe Interaction Network for RCOR2
     Regulatory tfbs in RCOR2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RCOR2 GenScript cDNA clones with any tag delivered in your preferred vector for RCOR2
     GenScript Custom Assay Services for RCOR2 GenScript Custom overexpressing Cell Line Services for RCOR2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RCOR2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RCOR2 antibodies
     Search for Antibodies for RCOR2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RCOR2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RCOR2
     Antibodies for RCOR2
     ELISAs for RCOR2
     CLIAs for RCOR2



     Browse ESI BIO Cell Lines and PureStem Progenitors for RCOR2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RCOR2
     SwitchGear 3'UTR luciferase reporter plasmids for RCOR2
     SwitchGear Promoter luciferase reporter plasmids for RCOR2
     Search ThermoFisher Antibodies for RCOR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RCOR2
     Browse compounds at ApexBio
     Search Addgene for plasmids for RCOR2
      Search eBioscience for proteins for RCOR2
      Search eBioscience for elisas for RCOR2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for RCOR2
     antibodies-online antibodies for RCOR2 (13 products)
     antibodies-online kits for RCOR2 (6 products)
     antibodies-online peptides for RCOR2
      Search antibodies-online for proteins for RCOR2
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RCOR2 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4